Indole derivatives with factor b inhibitory activity

Abstract

The present invention relates to active esters of Factor B inhibitors, and to associated salts, solvates, prodrugs and pharmaceutical compositions. The present invention further relates to methods of synthesising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by Factor B inhibition.

Description

[0001] Novel Compounds Field of the Invention The present invention relates to active esters of Factor B inhibitors, and to associated salts, solvates, prodrugs and pharmaceutical compositions. The present invention further relates to methods of synthesising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by Factor B inhibition. Background of the Invention The complement system is a critical part of the innate immune system and serves to help the body fight against infection from pathogens, ultimately leading to inflammation and phagocytic removal of pathogens or foreign particles. The complement system is comprised of multiple proteins, including zymogens which undergo proteolytic cleavage to become activated and facilitate the activation of further zymogens in the cascade. The proteins may be zymogens or proteins without potential for enzymatic activity that change conformation revealing binding sites for other components of the system. These successive enzymatic cleavages lead to a large, amplified response and many regulatory components exist in this system to prevent uncontrolled activation. The complement system can be activated via three pathways: classical, lectin, and alternative. The classical pathway is triggered by antigen:antibody complexes and connects the innate to the adaptive immune system. The lectin pathway is triggered directly by the pathogen when serum protein mannan-binding lectin, collectins or ficolins bind to bacterial or viral mannose-containing carbohydrates. The alternative pathway (also known as the alternate pathway) is initiated by activation of the central complement component, C3, either through spontaneous hydrolysis or enzymatic cleavage. The alternative pathway also serves as a critical amplification loop of all three pathways of complement activation. Ultimately, all of these pathways lead to the generation of C3 convertase which cleaves and activates further C3 molecules to promote: 1) opsonization of pathogens so they can be engulfed by phagocytes that recognise key receptors, 2) the recruitment of inflammatory cells by generating chemoattractants at the site of activation, and 3) formation of the C5 convertase resulting in production of C5a and C5b, the latter of which induces direct killing of pathogens by assembling terminal complement components to create membrane attack complex (MAC) pores in the membrane of bacteria or other target cells (Janeway, C. A. Jr. et al, (2001) The complement system and innate immunity, in Immunobiology: The Immune System in Health and Disease, Garland Science, New York). Factor B, a trypsin-like serine protease, is an element of the alternative pathway of the complement cascade. It exists in circulation in its zymogen form until the pathway becomes activated (Schubart, A. et al, Proc. Natl. Acad. Sci. U.S.A.2019, 116, 7926- 7931). Spontaneous steady-state hydrolysis of C3 leads to the formation of C3(H2O). Factor B can bind to the active forms of C3: C3(H2O) and C3b, generating the proenzyme C3bB (or C3(H2O)B), a target for activation by Factor D. Upon cleavage by Factor D, two fragments are generated: Ba and Bb (Schwaeble, W. J., Ali, Y. M., and Sim, R. B., (2020) Chapter 14 - The Roles and Contributions of the Complement System in the Pathophysiology of Autoimmune Diseases, in The Autoimmune Diseases (Sixth Edition) (Rose, N. R., and Mackay, I. R. eds.), Academic Press). Ba is released and Bb, containing a serine protease domain, remains bound to C3(H2O) and C3b, forming the alternative pathway C3 convertases [C3(H2O)Bb and C3bBb]. These trigger the amplification loop by converting C3 to C3a and more C3b. With the addition of yet another C3b to the C3 convertase, the C5 convertase is generated (C3bBbC3b) (Laskowski, J., Thurman, J. M. (2018) Chapter 14 - Factor B, in The Complement FactsBook (Second Edition) (Barnum, S., and Schein, T. eds.), Academic Press). C5 convertase cleaves C5 to generate the anaphylatoxin C5a, and C5b which serves as a platform for the formation of the membrane attack complex. Dysregulation of the alternative complement pathway due to genetics or the presence of autoantibodies can lead to many different diseases. Inhibition of Factor B is therefore a key therapeutic target for modulation of the alternative pathway and hence the treatment of numerous diseases, disorders and conditions. Iptacopan (LNP023), disclosed in Mainolfi et al., J. Med. Chem., 2020, vol.63, pp. 5697-5722, is a known Factor B inhibitor having the following structure:

[0002] Iptacopan is highly selective for Factor B, showing no inhibition of Factor D or the classical or lectin complement pathways. Also, no significant effects have been observed in a broad assay panel of receptors, ion channels, kinases, and proteases (Schubart, A. et al, Proc. Natl. Acad. Sci. U.S.A.2019, 116, 7926-7931). The drug has recently undergone successful phase III clinical studies in patients suffering from paroxysmal nocturnal hemoglobinuria (PNH) (Novartis Press Release, “Novartis Phase III APPOINT-PNH trial shows investigational oral monotherapy iptacopan improves hemoglobin to near-normal levels, leading to transfusion independence in all treatment-naïve PNH patients”, 26 April 2023). Further indole derivatives stated to have Factor B inhibitory activity are disclosed in WO 2013 / 164802 A1, US 2013 / 0296377 A1, WO 2014 / 143638 A1, WO 2015 / 009616 A1, WO 2022 / 028507 A1, WO 2022 / 028527 A1, WO 2022 / 143940 A1, WO 2022 / 143845 A1, WO 2022 / 155294 A1, WO 2022 / 218429 A1, WO 2022 / 256586 A2, WO 2023 / 278698 A1, WO 2023 / 020566 A1, WO 2023 / 072197 A1, WO 2023 / 139534 A1, WO 2023 / 187715 A1 and WO 2024 / 049977 A1. However, there is a need to provide further Factor B inhibitors, especially selective Factor B inhibitors (e.g. versus inhibition of Factor D, classical complement, and / or lectin complement activation). In particular, there is a need to provide compounds with improved pharmacological and / or physiological and / or physicochemical properties and / or those that provide a useful alternative to known compounds. Summary of the Invention A first aspect of the invention provides a compound of Formula (I):

[0003] Formula (I) wherein: R1is hydrogen; R2is selected from hydrogen or a halo group; R3is selected from hydrogen or a halo, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 5- or 6-membered heteroaryl ring; R9is an aryl or a heteroaryl group, wherein the aryl or the heteroaryl group is a monocylic group or a fused bicyclic or fused tricyclic group, and wherein the aryl or the heteroaryl group may optionally be substituted with one or more substituents each independently selected from a halo, -OH, -NH2, -NO2, -SH, -SO2H, -SO3H, -SO2NH2, -R90or -SO2R90group, wherein each R90is independently selected from a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R3and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. In one embodiment of the first aspect of the invention: R1is hydrogen; R2is selected from hydrogen or a halo group; R3is selected from hydrogen or a halo, -CN, C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 5- or 6-membered heteroaryl ring; R9is an aryl or a heteroaryl group, wherein the aryl or the heteroaryl group is a monocylic group or a fused bicyclic or fused tricyclic group, and wherein the aryl or the heteroaryl group may optionally be substituted with one or more substituents each independently selected from a halo, -OH, -NH2, -NO2, -SH, -SO2H, -SO3H, -SO2NH2, -R90or -SO2R90group, wherein each R90is independently selected from a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R3and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. A second aspect of the invention provides a compound of Formula (II): wherein: R1is hydrogen; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 5- or 6-membered heteroaryl ring; R9is an aryl or a heteroaryl group, wherein the aryl or the heteroaryl group is a monocylic group or a fused bicyclic or fused tricyclic group, and wherein the aryl or the heteroaryl group may optionally be substituted with one or more substituents each independently selected from a halo, -OH, -NH2, -NO2 -SH, -SO2H, -SO3H, -SO2NH2, -R90or -SO2R90group, wherein each R90is independently selected from a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; each R14and R15is independently selected from hydrogen or a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group, or R14and R15together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; R16is selected from hydrogen or a fluoro, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R17is selected from hydrogen or a fluoro, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; or R16and R17together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; or R17and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. In one embodiment of the second aspect of the invention: R1is hydrogen; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 5- or 6-membered heteroaryl ring; R9is an aryl or a heteroaryl group, wherein the aryl or the heteroaryl group is a monocylic group or a fused bicyclic or fused tricyclic group, and wherein the aryl or the heteroaryl group may optionally be substituted with one or more substituents each independently selected from a halo, -OH, -NH2, -NO2 -SH, -SO2H, -SO3H, -SO2NH2, -R90or -SO2R90group, wherein each R90is independently selected from a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; each R14and R15is independently selected from hydrogen or a C1-C4alkyl, C3-C4cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group, or R14and R15together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; R16is selected from hydrogen or a fluoro, -CN, C1-C4 alkyl, C3-C4 cycloalkyl, C1- C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; R17is selected from hydrogen or a fluoro, C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4 fluorocycloalkyl group; or R16and R17together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; or R17and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. A third aspect of the invention provides a compound of Formula (III):

[0004] Formula (III) wherein: R1is hydrogen; R2is selected from hydrogen or a halo group; R3is selected from hydrogen or a halo, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 5- or 6-membered heteroaryl ring; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R3and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R18is selected from hydrogen or a C1-C10saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R18that is directly attached to the reminder of the molecule is a carbon atom; and R19is selected from a C1-C10 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R18and R19may together form a C1-C10 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. In one embodiment of the third aspect of the invention: R1is hydrogen; R2is selected from hydrogen or a halo group; R3is selected from hydrogen or a halo, -CN, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4fluorocycloalkyl group; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 5- or 6-membered heteroaryl ring; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R3and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R18is selected from hydrogen or a C1-C10saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R18that is directly attached to the reminder of the molecule is a carbon atom; and R19is selected from a C1-C10 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R18and R19may together form a C1-C10 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. A fourth aspect of the invention provides a compound of Formula (IV): wherein: R1is hydrogen; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 5- or 6-membered heteroaryl ring; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; each R14and R15is independently selected from hydrogen or a C1-C4alkyl, C3-C4cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group, or R14and R15together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; R16is selected from hydrogen or a fluoro, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R17is selected from hydrogen or a fluoro, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4fluorocycloalkyl group; or R16and R17together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; or R17and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R18is selected from hydrogen or a C1-C10saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R18that is directly attached to the reminder of the molecule is a carbon atom; and R19is selected from a C1-C10 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R18and R19may together form a C1-C10 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. In one embodiment of the fourth aspect of the invention: R1is hydrogen; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 5- or 6-membered heteroaryl ring; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; each R14and R15is independently selected from hydrogen or a C1-C4alkyl, C3-C4cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group, or R14and R15together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; R16is selected from hydrogen or a fluoro, -CN, C1-C4 alkyl, C3-C4 cycloalkyl, C1- C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; R17is selected from hydrogen or a fluoro, C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4 fluorocycloalkyl group; or R16and R17together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; or R17and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R18is selected from hydrogen or a C1-C10 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R18that is directly attached to the reminder of the molecule is a carbon atom; and R19is selected from a C1-C10 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R18and R19may together form a C1-C10 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. In the context of the present specification, a “hydrocarbyl” substituent group or a hydrocarbyl moiety in a substituent group only includes carbon and hydrogen atoms but, unless stated otherwise, does not include any heteroatoms, such as N, O or S, in its carbon skeleton. A hydrocarbyl group / moiety may be saturated or unsaturated (including aromatic), and may be straight-chained or branched, or be or include cyclic groups wherein, unless stated otherwise, the cyclic group does not include any heteroatoms, such as N, O or S, in its carbon skeleton. Examples of hydrocarbyl groups include alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl and aryl groups / moieties and combinations of all of these groups / moieties. Typically a hydrocarbyl group is a C1-C20 hydrocarbyl group. More typically a hydrocarbyl group is a C1-C15 hydrocarbyl group. More typically a hydrocarbyl group is a C1-C10hydrocarbyl group. A “hydrocarbylene” group is similarly defined as a divalent hydrocarbyl group. An “alkyl” substituent group or an alkyl moiety in a substituent group may be linear (i.e. straight-chained) or branched. Examples of alkyl groups / moieties include methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl and n-pentyl groups / moieties. Unless stated otherwise, the term “alkyl” does not include “cycloalkyl”. Typically an alkyl group is a C1-C12 alkyl group. More typically an alkyl group is a C1-C6 alkyl group. An “alkylene” group is similarly defined as a divalent alkyl group. An “alkenyl” substituent group or an alkenyl moiety in a substituent group refers to an unsaturated alkyl group or moiety having one or more carbon-carbon double bonds. Examples of alkenyl groups / moieties include ethenyl, propenyl, 1-butenyl, 2-butenyl, 1- pentenyl, 1-hexenyl, 1,3-butadienyl, 1,3-pentadienyl, 1,4-pentadienyl and 1,4- hexadienyl groups / moieties. Unless stated otherwise, the term “alkenyl” does not include “cycloalkenyl”. Typically an alkenyl group is a C2-C12 alkenyl group. More typically an alkenyl group is a C2-C6 alkenyl group. An “alkenylene” group is similarly defined as a divalent alkenyl group. An “alkynyl” substituent group or an alkynyl moiety in a substituent group refers to an unsaturated alkyl group or moiety having one or more carbon-carbon triple bonds. Examples of alkynyl groups / moieties include ethynyl, propargyl, but-1-ynyl and but-2- ynyl groups / moieties. Typically an alkynyl group is a C2-C12 alkynyl group. More typically an alkynyl group is a C2-C6 alkynyl group. An “alkynylene” group is similarly defined as a divalent alkynyl group. A “cyclic” substituent group or a cyclic moiety in a substituent group refers to any hydrocarbyl ring, wherein the hydrocarbyl ring may be saturated or unsaturated (including aromatic) and may include one or more heteroatoms, e.g. N, O or S, in its carbon skeleton. Examples of cyclic groups include cycloalkyl, cycloalkenyl, heterocyclic, aryl and heteroaryl groups as discussed below. A cyclic group may be monocyclic, bicyclic (e.g. bridged, fused or spiro), or polycyclic. Typically, a cyclic group is a 3- to 12-membered cyclic group, which means it contains from 3 to 12 ring atoms. More typically, a cyclic group is a 3- to 7-membered monocyclic group, which means it contains from 3 to 7 ring atoms. For the avoidance of doubt, where it is stated that a bicyclic or polycyclic group or moiety is “saturated” it is to be understood that all of the ring systems within the bicyclic or polycyclic group or moiety (excluding any ring systems which are part of or formed by optional substituents) are saturated. A “heterocyclic” substituent group or a heterocyclic moiety in a substituent group refers to a cyclic group or moiety including one or more carbon atoms and one or more (such as one, two, three or four) heteroatoms, e.g. N, O or S, in the ring structure. Examples of heterocyclic groups include heteroaryl groups as discussed below and non-aromatic heterocyclic groups such as azetinyl, azetidinyl, oxetanyl, thietanyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrazolidinyl, imidazolidinyl, dioxolanyl, oxathiolanyl, piperidinyl, tetrahydropyranyl, thianyl, piperazinyl, dioxanyl, morpholinyl and thiomorpholinyl groups. A “cycloalkyl” substituent group or a cycloalkyl moiety in a substituent group refers to a saturated hydrocarbyl ring containing, for example, from 3 to 7 carbon atoms, examples of which include cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. Unless stated otherwise, a cycloalkyl substituent group or moiety may include monocyclic, bicyclic or polycyclic hydrocarbyl rings. A “cycloalkenyl” substituent group or a cycloalkenyl moiety in a substituent group refers to a non-aromatic unsaturated hydrocarbyl ring having one or more carbon- carbon double bonds and containing, for example, from 3 to 7 carbon atoms, examples of which include cyclopent-1-en-1-yl, cyclohex-1-en-1-yl and cyclohex-1,3-dien-1-yl. Unless stated otherwise, a cycloalkenyl substituent group or moiety may include monocyclic, bicyclic or polycyclic hydrocarbyl rings. An “aryl” substituent group or an aryl moiety in a substituent group refers to an aromatic hydrocarbyl ring. The term “aryl” refers to monocyclic aromatic hydrocarbons and polycyclic fused ring aromatic hydrocarbons wherein all of the fused ring systems (excluding any ring systems which are part of or formed by optional substituents) are aromatic. Examples of aryl groups / moieties include phenyl, naphthyl, anthracenyl and phenanthrenyl. Unless stated otherwise, the term “aryl” does not include “heteroaryl”. A “heteroaryl” substituent group or a heteroaryl moiety in a substituent group refers to an aromatic heterocyclic group or moiety. The term “heteroaryl” refers to monocyclic aromatic heterocycles and polycyclic fused ring aromatic heterocycles wherein all of the fused ring systems (excluding any ring systems which are part of or formed by optional substituents) are aromatic. Examples of heteroaryl groups / moieties include the following:

[0005] wherein G = O, S or NH. Particular examples of 5- or 6-membered heteroaryl groups include furanyl, thiophenyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, triazolyl, furazanyl, oxadiazolyl, thiadiazolyl, tetrazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl groups. Unless stated otherwise, where a bicyclic or polycyclic group or moiety is stated to be aromatic, such as an aryl or a heteroaryl group, it is to be understood that all of the ring systems within the bicyclic or polycyclic group or moiety (excluding any ring systems which are part of or formed by optional substituents) are aromatic. Similarly, where a bicyclic or polycyclic group or moiety is stated to be non-aromatic, such as a cycloalkyl, cycloalkenyl or non-aromatic heterocyclic group, it is to be understood that all of the ring systems within the bicyclic or polycyclic group or moiety (excluding any ring systems which are part of or formed by optional substituents) are non-aromatic. For the purposes of the present specification, where a combination of moieties is referred to as one group, for example, arylalkyl, arylalkenyl, arylalkynyl, alkylaryl, alkenylaryl or alkynylaryl, the last mentioned moiety contains the atom by which the group is attached to the rest of the molecule. An example of an arylalkyl group is benzyl. As will be appreciated, in an optionally substituted moiety: - each hydrogen atom may optionally be replaced by any specified monovalent substituent; - any two hydrogen atoms attached to the same carbon or nitrogen atom may optionally be replaced by any specified π-bonded substituent; - any sulphur atom may optionally be substituted with one or two of any specified π-bonded substituents; and - any two hydrogen atoms attached to the same or different atoms, within the same optionally substituted group or moiety, may optionally be replaced by any specified divalent bridging substituent. Typically a substituted group comprises 1, 2, 3 or 4 substituents, more typically 1, 2 or 3 substituents, more typically 1 or 2 substituents, and more typically 1 substituent. Unless stated otherwise, any divalent bridging substituent (e.g. -O-, -S-, -NH-, -CH2-, -CH2-CH2-, etc.) of an optionally substituted group or moiety (e.g. R1) must only be attached to the specified group or moiety and may not be attached to a second group or moiety (e.g. R2), even if the second group or moiety can itself be optionally substituted. The term “halo” includes fluoro, chloro, bromo and iodo. Unless stated otherwise, where a group is prefixed by the term “halo”, such as a haloalkyl or halomethyl group, it is to be understood that the group in question is substituted with one or more halo groups independently selected from fluoro, chloro, bromo and iodo. Typically, the maximum number of halo substituents is limited only by the number of hydrogen atoms available for substitution on the corresponding group without the halo prefix. For example, a halomethyl group may contain one, two or three halo substituents. A haloethyl or halophenyl group may contain one, two, three, four or five halo substituents. Similarly, unless stated otherwise, where a group is prefixed by a specific halo group, it is to be understood that the group in question is substituted with one or more of the specific halo groups. For example, the term “fluoromethyl” refers to a methyl group substituted with one, two or three fluoro groups. Similarly, unless stated otherwise, where a group is said to be “halo-substituted”, it is to be understood that the group in question is substituted with one or more halo groups independently selected from fluoro, chloro, bromo and iodo. Typically, the maximum number of halo substituents is limited only by the number of hydrogen atoms available for substitution on the group said to be halo-substituted. For example, a halo- substituted methyl group may contain one, two or three halo substituents. A halo- substituted ethyl or halo-substituted phenyl group may contain one, two, three, four or five halo substituents. Unless stated otherwise, any reference to an element is to be considered a reference to all isotopes of that element. Thus, for example, unless stated otherwise any reference to hydrogen is considered to encompass all isotopes of hydrogen including deuterium and tritium. Unless stated otherwise, any reference to a compound or group is to be considered a reference to all tautomers of that compound or group. Where reference is made to a hydrocarbyl or other group including one or more heteroatoms N, O or S in its carbon skeleton, or where reference is made to a carbon atom of a hydrocarbyl or other group being replaced by an N, O or S atom, what is intended is that: is replaced by ; . .is replaced by –CH2– is replaced by –NH–, –O– or –S–; –CH3is replaced by –NH2, –OH or –SH; –CH= is replaced by –N=; CH2= is replaced by NH=, O= or S=; or CH≡ is replaced by N≡; provided that the resultant group comprises at least one carbon atom. For example, methoxy, dimethylamino and aminoethyl groups are considered to be hydrocarbyl groups including one or more heteroatoms N, O or S in their carbon skeleton. Typically, the compounds of the invention contain no more than one quaternary ammonium group. More typically, the compounds of the invention contain no quaternary ammonium groups. In the context of the present specification, unless otherwise stated, a Cx-Cygroup is defined as a group containing from x to y carbon atoms. For example, a C1-C4alkyl group is defined as an alkyl group containing from 1 to 4 carbon atoms. For the purposes of allocating x and y in a Cx-Cy group, optional substituents are not taken into account when calculating the total number of carbon atoms in the parent group substituted with the optional substituents. For the avoidance of doubt, replacement heteroatoms, e.g. N, O or S, are not to be counted as carbon atoms when calculating the number of carbon atoms in a Cx-Cy group. For example, a morpholinyl group is to be considered a C4 heterocyclic group, not a C6 heterocyclic group. For the purposes of the present specification, where it is stated that a first atom or group is “directly attached” to a second atom or group it is to be understood that the first atom or group is covalently bonded to the second atom or group with no intervening atom(s) or group(s) being present. So, for example, for the group -(C=O)N(CH3)2, the carbon atom of each methyl group is directly attached to the nitrogen atom and the carbon atom of the carbonyl group is directly attached to the nitrogen atom, but the carbon atom of the carbonyl group is not directly attached to the carbon atom of either methyl group. As stated in accordance with the first and third aspects of the invention, R2is selected from hydrogen or a halo group. In one embodiment, R2is selected from hydrogen or a fluoro, chloro or bromo group. Most typically, R2is hydrogen. As stated, in one embodiment of the first and third aspects of the invention, R3is selected from hydrogen or a halo, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. In one aspect of such an embodiment, R3is selected from hydrogen or a halo (e.g. fluoro, chloro or bromo), -R30, -CN, -CHO, -COR30, -CO2H or -CO2R30group, wherein R30is selected from a C1-C6 alkyl, C1-C6 fluoroalkyl, C2-C6 alkenyl, C2-C6 fluoroalkenyl or -R31group, wherein R31is a 3- to 6-membered monocyclic group, wherein the 3- to 6- membered monocyclic group may optionally be substituted with one or more halo (e.g. fluoro, chloro or bromo) groups, and / or with one or two groups R32, wherein each R32is independently selected from a methyl or a fluoromethyl group, provided that the group R3, including any optional substituents, contains no more than 8 carbon atoms. Typically in such an embodiment, R3is selected from hydrogen or a fluoro, chloro, bromo, -R30, -CN, -CHO, -COR30, -CO2H or -CO2R30group, wherein R30is selected from a C1-C4 alkyl, C1-C4 fluoroalkyl or -R31group, wherein R31is selected from a C3-C6 cycloalkyl group, a 4- to 6-membered saturated heterocyclic group, or a phenyl or a 5- or 6-membered heteroaryl group, wherein the C3-C6 cycloalkyl group and the 4- to 6- membered saturated heterocyclic group may optionally be substituted with one or more fluoro groups and / or with one or two groups R32, and wherein the phenyl or the 5- or 6- membered heteroaryl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and / or with one or two groups R32, provided that the group R3, including any optional substituents, contains no more than 8 carbon atoms. More typically in such an embodiment, R3is selected from hydrogen or a fluoro, chloro, bromo, -R30, -R31, -CN, -CHO, -COR30, -CO2H or -CO2R30group, wherein R30is selected from a methyl or fluoromethyl group, and wherein R31is a 5-membered heteroaryl group, wherein the 5-membered heteroaryl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and / or with one or two groups R32. In another aspect of such an embodiment, R3is selected from hydrogen or a halo (e.g. fluoro, chloro or bromo), -R30, -CN, -CHO, -COR30, -CO2H or -CO2R30group, wherein R30is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group. Typically in such an embodiment, R3is selected from hydrogen or a fluoro, chloro, bromo -R30, -CN, -CHO, -COR30, -CO2H or -CO2R30group, wherein R30is selected from a methyl or fluoromethyl group. In a further aspect of such an embodiment, R3is selected from hydrogen or a halo (e.g. fluoro, chloro or bromo), -CN, C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group. Typically in such an embodiment, R3is selected from hydrogen or a fluoro, chloro, bromo, -CN or methyl group, wherein the methyl group may optionally be fluoro substituted. More typically, R3is selected from hydrogen or a fluoro, chloro or bromo group. Most typically, R3is hydrogen. As stated, in one embodiment of any of the first to fourth aspects of the invention, R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. Typically in such an embodiment, R4is selected from hydrogen or a fluoro, chloro, bromo, -OH, -NH2, -SO2NH2, -SO2-R40or -R40group, wherein R40is selected from a C1- C6 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton. More typically in such an embodiment, R4is selected from a fluoro, chloro, bromo, -OH, -OR41, -N(R42)2, -SO2-R41, -SO2-N(R42)2, -L4-OH, -L4-OR41, -L4-N(R42)2, -L4-SO2-R41, -L4-SO2-N(R42)2, -O-L4-OH, -O-L4-OR41, -O-L4-N(R42)2, -O-L4-SO2-R41, -O-L4-SO2-N(R42)2, -NR43-L4-OH, -NR43-L4-OR41, -NR43-L4-N(R42)2, -NR43-L4-SO2-R41, -NR43-L4-SO2-N(R42)2, -SO2-L4-OH, -SO2-L4-OR41, -SO2-L4-N(R42)2,-R44, -R45or -L4-R45group, wherein: R41is selected from a -R44or -R45group; each R42is independently selected from hydrogen or a -R44or -R45group, or any two R42may, together with the nitrogen atom to which they are attached, form a 3- to 6-membered saturated monocyclic heterocyclic group, wherein the 3- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or two oxo (=O) groups and / or with one or more fluoro, methyl and / or fluoromethyl groups; L4is a straight-chained alkylene group, wherein the straight-chained alkylene group optionally includes one or two heteroatoms each independently selected from O and N in its carbon skeleton, wherein L4has a chain length of from 1 to 4 atoms, and wherein L4may optionally be substituted with one or two oxo (=O) groups and / or with one or more groups RL4; each RL4is independently selected from a fluoro, methyl or fluoromethyl group; or any RL4and R41, or any RL4and any R42, may together with the atoms to which they are attached, form a 3- to 6-membered saturated monocyclic heterocyclic group, wherein the 3- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or two oxo (=O) groups and / or with one or more fluoro, methyl and / or fluoromethyl groups; R43is selected from hydrogen or a -R44group; each R44is independently selected from a C1-C4 alkyl or C3-C6 cycloalkyl group, wherein the C1-C4 alkyl or C3-C6 cycloalkyl group may optionally be substituted with one or more fluoro groups and / or one or two oxo (=O) groups; and each R45is independently selected from a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more groups each independently selected from fluoro, chloro and bromo, and / or with one or two groups each independently selected from methyl (Me), -CN, -OH, -OMe, -NH2, -NHMe, and -NMe2, wherein any methyl group of R45may optionally be fluoro substituted; provided that R4, including any optional substituents, contains no more than 8 carbon atoms. In one aspect of such an embodiment: R4is selected from a fluoro, chloro, bromo, -OH, -OR41, -N(R42)2, -SO2-R41, -SO2-N(R42)2, -L4-OH, -L4-OR41, -L4-N(R42)2, -L4-SO2-R41, -L4-SO2-N(R42)2, -O-L4-OH, -O-L4-OR41, -O-L4-N(R42)2, -O-L4-SO2-R41, -O-L4-SO2-N(R42)2, -NR43-L4-OH, -NR43-L4-OR41, -NR43-L4-N(R42)2, -NR43-L4-SO2-R41, -NR43-L4-SO2-N(R42)2, -R44, -R45or -L4-R45group; R41is selected from a -R44or -R45group; each R42is independently selected from hydrogen or a -R44or -R45group, or any two R42may, together with the nitrogen atom to which they are attached, form a 3- to 6-membered saturated monocyclic heterocyclic group, wherein the 3- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or more fluoro groups and / or one or two oxo (=O) groups; and L4is a straight-chained alkylene group, wherein the straight-chained alkylene group optionally includes one or two heteroatoms each independently selected from O and N in its carbon skeleton, wherein L4has a chain length of from 1 to 4 atoms, and wherein L4may optionally be substituted with one or two oxo (=O) groups and / or with one or more groups RL4, wherein each RL4is independently selected from a fluoro, methyl or fluoromethyl group; or any RL4and R41, or any RL4and any R42, may together with the atoms to which they are attached, form a 3- to 6-membered saturated monocyclic heterocyclic group, wherein the 3- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or more fluoro groups and / or one or two oxo (=O) groups. Thus, for example, R4may be a bromo or a chloro group, or a -R44group such as a methyl, -CF3 or cyclopropyl group, or a -OR41group such as a -OMe, -OCD3, -OCHF2 or -OCH2CHF2 group, or a -SO2-R41group such as a -SO2Me or -SO2Et group, or a -O-L4-N(R42)2group such as a -OCH2CH2NHMe group, or a -L4-N(R42)2group such as a -CONHMe group. Typically, R4, including any optional substituents, contains no more than 6 carbon atoms. Typically, the total number of nitrogen, oxygen and sulphur atoms in R4, including any optional substituents, is no more than four. More typically, the total number of nitrogen, oxygen and sulphur atoms in R4, including any optional substituents, is no more than three. In a more typical embodiment, R4is selected from a fluoro, chloro, bromo, -OH, -OR44, -N(R42)2, -COOH, -COOR44, -CON(R42)2, -SO2-R44, -SO2-N(R42)2, -O-L4-OH, -O-L4-OR44, -O-L4-N(R42)2, -NR43-L4-OH, -NR43-L4-OR44, -NR43-L4-N(R42)2, or -R44group, wherein: each R42is independently selected from hydrogen or a -R44group; R43is selected from hydrogen or a -R44group; each R44is independently selected from a C1-C4 alkyl or C3-C6 cycloalkyl group, wherein the C1-C4 alkyl or C3-C6 cycloalkyl group may optionally be substituted with one or more fluoro groups and / or one or two oxo (=O) groups; and L4is a -CH2-CH2-, -CH2-CHMe-, -CH2-CMe2-, -CHMe-CH2-, -CHMe-CHMe-, -CHMe-CMe2-, -CMe2-CH2-, -CMe2-CHMe- or -CMe2-CMe2- group, wherein any -CH2-, -CHMe- or -CMe2- group may optionally be fluoro substituted. Typically in such an embodiment, R4is selected from a fluoro, chloro, bromo, -OR44, -CON(R42)2, -SO2-R44, -SO2-N(R42)2, -O-CH2-CH2-OR44, -O-CH2-CH2-N(R42)2, or -R44group. Typically, each R44is independently selected from a C1-C4alkyl or C3-C6cycloalkyl group, wherein the C1-C4 alkyl or C3-C6 cycloalkyl group may optionally be substituted with one or more fluoro groups. More typically, each R44is independently selected from a C1-C3alkyl, cyclopropyl, C1-C3fluoroalkyl or fluorocyclopropyl group. In one aspect of such an embodiment, R4is selected from a fluoro, chloro, bromo, -OR44-SO2-R44, -SO2-N(R42)2, -O-CH2-CH2-N(R42)2, or -R44group. More typically, R4is selected from a fluoro, chloro, bromo, -R44or -OR44group. Typically in such an embodiment, R44is selected from a C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group. Yet more typically, R4is selected from a fluoro, chloro, bromo, methyl (Me) or -OMe group, wherein any methyl group may optionally be fluoro substituted. More typically still, R4is selected from a methyl (Me) or -OMe group, wherein any methyl group may optionally be fluoro substituted. Most typically, R4is -OMe. As stated in accordance with each of the first to fourth aspects of the invention, R5is selected from hydrogen or a halo group. In one embodiment, R5is selected from hydrogen or a fluoro, chloro or bromo group. More typically, R5is selected from hydrogen or a fluoro group. Most typically, R5is hydrogen. As stated in accordance with each of the first to fourth aspects of the invention, R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group. More typically, R6is selected from a fluoro, chloro, bromo, -R60or -OR60group. More typically still, R6is selected from a chloro, bromo, -R60or -OR60group. Yet more typically, R6is selected from a -R60or -OR60group. In one embodiment, R60is selected from a C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group. For example, R6may be selected from a -R60or -OR60group, and R60may be selected from a C1-C3alkyl, cyclopropyl, C1-C3fluoroalkyl or fluorocyclopropyl group. Typically, R60is selected from a methyl, fluoromethyl, ethyl or fluoroethyl group. More typically still, R60is selected from a methyl or fluoromethyl group. In a further embodiment, R6is a methyl or a fluoromethyl group. More typically, R6is a methyl group. As stated, in one embodiment of each of the first to fourth aspects of the invention, R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom, or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton. In one embodiment, R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom. For example, R7may be selected from hydrogen or a fluoro or a C1-C12saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7that is directly attached to the reminder of the molecule is a carbon atom, and R8may be selected from hydrogen or a fluoro, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group. In another embodiment, R7and R8are each independently selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom. For example, R7may be selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7that is directly attached to the reminder of the molecule is a carbon atom, and R8may be selected from hydrogen or a fluoro, C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group. In yet another embodiment, R7and R8are each independently selected from hydrogen or a fluoro or a C1-C6saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom. For example, R7may be selected from hydrogen or a fluoro or a C1-C6 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton, provided that the atom of any hydrocarbyl group of R7that is directly attached to the reminder of the molecule is a carbon atom, and R8may be selected from hydrogen or a fluoro, methyl or fluoromethyl group. In one embodiment, R7and R8are each independently selected from hydrogen or a fluoro, -CN, -COOH, -COOR71, -CO-N(R72)2, -L7-COOH, -L7-COOR71, -L7-CO-N(R72)2, -L7-OH, -L7-OR71, -L7-N(R72)2, -R73, -R74or -L7-R74group, wherein: each R71is independently selected from a -R73or -R74group; each R72is independently selected from hydrogen or a -R73or -R74group, or any two R72may, together with the nitrogen atom to which they are attached, form a 3- to 6- membered saturated monocyclic heterocyclic group, wherein the 3- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or two oxo (=O) groups and / or with one or more fluoro, methyl and / or fluoromethyl groups; each L7is independently selected from a straight-chained alkylene or alkenylene group, wherein the straight-chained alkylene or alkenylene group optionally includes one or two heteroatoms each independently selected from O and N in its carbon skeleton, wherein L7has a chain length of from 1 to 4 atoms, and wherein L7may optionally be substituted with one or two oxo (=O) groups and / or with one or more groups RL7; each RL7is independently selected from a fluoro, methyl or fluoromethyl group; or any two RL7may, together with the atom or atoms to which they are attached, form a 3- to 6-membered monocyclic group, wherein the 3- to 6-membered monocyclic group is saturated or monounsaturated, and wherein the 3- to 6-membered monocyclic group may optionally be substituted with one or two oxo (=O) groups and / or with one or more fluoro, methyl and / or fluoromethyl groups; or any RL7and R71, or any RL7and any R72, may together with the atoms of the -L7-COOR71, -L7-CO-N(R72)2, -L7-OR71or -L7-N(R72)2 group to which they are attached, form a 3- to 6-membered monocyclic heterocyclic group, wherein the 3- to 6- membered monocyclic heterocyclic group is saturated or monounsaturated, and wherein the 3- to 6-membered monocyclic heterocyclic group may optionally be substituted with one or two oxo (=O) groups and / or with one or more fluoro, methyl and / or fluoromethyl groups; each R73is independently selected from a C1-C4alkyl, C2-C4alkenyl, C3-C6cycloalkyl or C5-C6 cycloalkenyl group, wherein the C1-C4 alkyl, C2-C4 alkenyl, C3-C6 cycloalkyl or C5-C6 cycloalkenyl group may optionally be substituted with one or more fluoro groups and / or one or two oxo (=O) groups; and each R74is independently selected from a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more groups each independently selected from fluoro, chloro and bromo, and / or with one or two groups each independently selected from methyl (Me), -CN, -OH, -OMe, -NH2, -NHMe, and -NMe2, wherein any methyl group of R74may optionally be fluoro substituted; provided that any R7or R8group, including any optional substituents, contains no more than 12 carbon atoms, and that each atom of R7or R8that is directly attached to the reminder of the molecule is a carbon, hydrogen or fluorine atom. Typically in such an embodiment, R7is selected from hydrogen or a fluoro, -CN, -COOH, -COOR71, -CO-N(R72)2, -L7-COOH, -L7-COOR71, -L7-CO-N(R72)2, -L7-OH, -L7-OR71, -L7-N(R72)2, -R73, -R74or -L7-R74group, and R8is selected from a hydrogen or a fluoro, methyl or fluoromethyl group. Thus, for example, R7may be hydrogen or a -R73group such as a methyl, -CF3, ethyl, isopropyl or -CH2CH2CH=CH2group, or a -COOH group, or a -L7-COOH group such as a -CMe2COOH, -CH2COOH, -CH2CH2COOH, or group, or a -L7-COOR71group such as a -CMe2COOMe, -CH2CH2COOMe or -CH2COOEt group, or a -L7-CO-N(R72)2group such as a group, or a -L7-OH group such as a -CMe2CH2OH, or group, or a -L7-OR71group such as a -CH2OMe group, or a -L7-N(R72)2group such as a or group. As will be understood for example, where R7is a -L7-COOH group selected from , or , L7may be seen as a straight-chained alkylene group substituted with two RL7groups, wherein the two RL7together form a -CH2CH2-, -CH2- or -CF2- group respectively, such that the two RL7and the carbon atom or atoms to which they are attached together form a cyclopropyl or fluorocyclopropyl group. Similarly, where R7is a -L7-N(R72)2group selected from or , L7may be seen as a straight-chained alkylene group substituted with a single RL7group, wherein the RL7and one R72group together form a -CH2CH2- or -CH2CH2CH2- group respectively, such that the RL7and the R72together with the atoms of the -L7-N(R72)2 group to which they are attached together form a saturated 5- or 6- membered monocyclic heterocyclic group. Typically in the above embodiments, any R7or R8group, including any optional substituents, contains no more than 10 carbon atoms. More typically, any R7or R8group, including any optional substituents, contains no more than 8 carbon atoms. In yet another embodiment, R7and R8are each independently selected from hydrogen or a fluoro, -CN, -COOH, -COOR71, -L7-COOH, -L7-COOR71, -L7-OH, -L7-OR71, -L7-N(R72)2, -R73, -R74or -L7-R74group, wherein: each R71is independently selected from a -R73or -R74group; each R72is independently selected from hydrogen or a -R73or -R74group, or any two R72may, together with the nitrogen atom to which they are attached, form a 3- to 6- membered saturated monocyclic heterocyclic group, wherein the 3- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or more fluoro groups and / or one or two oxo (=O) groups; each L7is independently selected from a straight-chained alkylene group, wherein the straight-chained alkylene group optionally includes one or two heteroatoms each independently selected from O and N in its carbon skeleton, wherein L7has a chain length of from 1 to 4 atoms, and wherein L7may optionally be substituted with one or two oxo (=O) groups and / or with one or more groups RL7, wherein each RL7is independently selected from a fluoro, methyl or fluoromethyl group; or any RL7and R71, or any RL7and any R72, may together with the atoms of the -L7-COOR71, -L7-OR71or -L7-N(R72)2 group to which they are attached, form a 3- to 6- membered saturated monocyclic heterocyclic group, wherein the 3- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or more fluoro groups and / or one or two oxo (=O) groups; each R73is independently selected from a C1-C4 alkyl, C2-C4 alkenyl, C3-C6 cycloalkyl or C5-C6cycloalkenyl group, wherein the C1-C4alkyl, C2-C4alkenyl, C3-C6cycloalkyl or C5-C6 cycloalkenyl group may optionally be substituted with one or more fluoro groups and / or one or two oxo (=O) groups; and each R74is independently selected from a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more groups each independently selected from fluoro, chloro and bromo, and / or with one or two groups each independently selected from methyl (Me), -CN, -OH, -OMe, -NH2, -NHMe, and -NMe2, wherein any methyl group of R74may optionally be fluoro substituted; provided that any R7or R8group, including any optional substituents, contains no more than 8 carbon atoms, and that each atom of R7or R8that is directly attached to the reminder of the molecule is a carbon, hydrogen or fluorine atom. Typically in such an embodiment, R7is selected from hydrogen or a fluoro, -CN, -COOH, -COOR71, -L7-COOH, -L7-COOR71, -L7-OH, -L7-OR71, -L7-N(R72)2, -R73, -R74or -L7-R74group, and R8is selected from a hydrogen or a fluoro, methyl or fluoromethyl group. In one aspect of such an embodiment, R7and R8are each independently selected from hydrogen or a fluoro, -CN, -COOH, -L7-COOH, -L7-OH, -L7-OR71, -L7-N(R72)2, -R73, -R74or -L7-R74group, and each R73is independently selected from a C1-C4alkyl or C3-C6cycloalkyl group, wherein the C1-C4 alkyl or C3-C6 cycloalkyl group may optionally be substituted with one or more fluoro groups and / or one or two oxo (=O) groups. Typically in such an aspect, R7is selected from hydrogen or a fluoro, -CN, -COOH, -L7-COOH, -L7-OH, -L7-OR71, -L7-N(R72)2, -R73, -R74or -L7-R74group, and R8is selected from a hydrogen or a fluoro, methyl or fluoromethyl group. Typically in the above embodiment, any R7or R8group, including any optional substituents, contains no more than 6 carbon atoms. Typically, the total number of nitrogen, oxygen and sulphur atoms in any R7or R8group, including any optional substituents, is no more than four. More typically, the total number of nitrogen, oxygen and sulphur atoms in any R7or R8group, including any optional substituents, is no more than three. In a further embodiment, R7and R8are each independently selected from hydrogen or a fluoro, -COOH, -COOR75, -CONH2, -CONHR75, -CON(R75)2, -L71-COOH, -L71-COOR75, -L71-CONH2, -L71-CONHR75, -L71-CON(R75)2, -L71-OH, -L71-OR75or -R75group, wherein: each -L71- is independently selected from a -CH2-, -CHMe-, -CMe2-, , -CH2-CH2-, -CH2-CHMe-, -CH2-CMe2-, -CHMe-CH2-, -CHMe-CHMe-, -CHMe-CMe2-, -CMe2-CH2-, -CMe2-CHMe-, -CMe2-CMe2-, , , , -CH2-CH2-CH2-, -CHMe-CH2-CH2-, -CH2-CHMe-CH2-, -CH2-CH2-CHMe-, -CMe2-CH2-CH2-, -CHMe-CHMe-CH2-, -CHMe-CH2-CHMe-, -CH2-CMe2-CH2-, -CH2-CHMe-CHMe-, -CH2-CH2-CMe2-, -CMe2-CHMe-CH2-, -CMe2-CH2-CHMe-, -CHMe-CHMe2-CH2-, -CHMe-CHMe-CHMe-, -CHMe-CH2-CMe2-, -CH2-CMe2-CHMe-, -CH2-CHMe-CMe2-, -CMe2-CMe2-CH2-, -CMe2-CHMe-CHMe-, -CMe2-CH2-CMe2-, -CHMe-CMe2-CHMe-, -CHMe-CHMe-CMe2-, -CH2-CMe2-CMe2-, , , , or group, wherein any -L71- moiety may optionally be fluoro substituted; and each R75is independently selected from a C1-C4 alkyl, C2-C4 alkenyl, cyclopropyl, cyclobutyl, C1-C4fluoroalkyl, C2-C4fluoroalkenyl, fluorocyclopropyl or fluorocyclobutyl group, or any two R75attached to the same nitrogen atom may together with the nitrogen atom to which they are attached form a 4- to 6-membered saturated monocyclic heterocyclic group, such as an azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl or piperazinyl group, wherein the 4- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or more fluoro groups and / or with one or two methyl groups, wherein said methyl groups may optionally be fluoro-substituted; provided that any R7or R8group, including any optional substituents, contains no more than 12 carbon atoms. Typically in such an embodiment, R7is selected from from hydrogen or a fluoro, -COOH, -COOR75, -CONH2, -CONHR75, -CON(R75)2, -L71-COOH, -L71-COOR75, -L71-CONH2, -L71-CONHR75, -L71-CON(R75)2, -L71-OH, -L71-OR75or -R75group, and R8is selected from a hydrogen or a fluoro, methyl or fluoromethyl group. More typically, R8is hydrogen. Typically, where R7is selected from from hydrogen or a fluoro, -COOH, -COOR75, -CONH2, -CONHR75, -CON(R75)2, -L71-COOH, -L71-COOR75, -L71-CONH2, -L71-CONHR75, -L71-CON(R75)2, -L71-OH, -L71-OR75or -R75group, R7(including any optional substituents) contains no more than 10 carbon atoms. In another embodiment, R7and R8are each independently selected from hydrogen or a fluoro, -COOH, -COOR75, -L71-COOH, -L71-COOR75, -L71-OH, -L71-OR75or -R75group, wherein: each -L71- is independently selected from a -CH2-, -CHMe-, -CMe2-, -CH2-CH2-, -CH2-CHMe-, -CH2-CMe2-, -CHMe-CH2-, -CHMe-CHMe-, -CHMe-CMe2-, -CMe2-CH2-, -CMe2-CHMe- or -CMe2-CMe2- group, wherein any -CH2-, -CHMe- or -CMe2- group may optionally be fluoro substituted; and each R75is independently selected from a C1-C4alkyl, C2-C4alkenyl, cyclopropyl, cyclobutyl, C1-C4 fluoroalkyl, C2-C4 fluoroalkenyl, fluorocyclopropyl or fluorocyclobutyl group. Typically in such an embodiment, R7is selected from hydrogen or a fluoro, -COOH, -COOR75, -L71-COOH, -L71-COOR75, -L71-OH, -L71-OR75or -R75group, and R8is selected from a hydrogen or a fluoro, methyl or fluoromethyl group. Typically in such an embodiment, each -L71- is independently selected from a -CH2-, -CHMe-, -CMe2-, -CH2-CH2-, -CH2-CHMe-, -CH2-CMe2-, -CHMe-CH2-, -CHMe-CHMe- or -CMe2-CH2- group, wherein any -CH2-, -CHMe- or -CMe2- group may optionally be fluoro substituted. Typically in such an embodiment, R7including any optional substituents, contains no more than 6 carbon atoms, and R8is selected from a hydrogen or a fluoro, methyl or fluoromethyl group. More typically, R7including any optional substituents, contains no more than 5 carbon atoms, and R8is selected from a hydrogen or a fluoro, methyl or fluoromethyl group. In another embodiment, R7and R8are each independently selected from hydrogen or a fluoro, -L71-COOH, -L71-COOR75, -L71-OH, -L71-OR75or -R75group, wherein: each -L71- is independently selected from a -CH2-, -CHMe- or -CMe2- group, wherein any -CH2-, -CHMe- or -CMe2- group may optionally be fluoro substituted; and each R75is independently selected from a C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group. Typically in such an embodiment, R7is selected from hydrogen or a fluoro, -L71-COOH, -L71-COOR75, -L71-OH, -L71-OR75or -R75group, and R8is selected from a hydrogen or a fluoro, methyl or fluoromethyl group. In another embodiment, R7and R8are each independently selected from hydrogen or a fluoro, methyl or fluoromethyl group. For example, R7may be selected from hydrogen or a fluoro, methyl or fluoromethyl group, and R8may be hydrogen or a fluoro group. In one embodiment, at least one of R7and R8is hydrogen. Typically, R8is hydrogen. In a further embodiment, R7and R8are both hydrogen. In one embodiment, R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton. Typically in such an embodiment, R7and R8together with the carbon atom to which they are attached form a 3- to 6-membered saturated monocyclic group, such that each ring atom of the saturated monocyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the saturated monocyclic group may optionally be substituted with one or more fluoro groups and / or one or two substituents each independently selected from oxo (=O), -CN, or a C1-C3 saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight- chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O in its carbon skeleton. For example, R7and R8may together form a group -L78-, wherein -L78- is selected from a -CH2-CH2-, -CH2-CH2-CH2-, -CH2-NH-CH2-, -CH2-O-CH2-, -CH2-CH2-CH2-CH2-, -CH2-CH2-NH-CH2-, -CH2-CH2-O-CH2-, -CH2-NH-CH2-CH2- or -CH2-O-CH2-CH2- group, and wherein -L78- may optionally be substituted with one or more fluoro groups and / or one or two substituents each independently selected from an oxo (=O), -CN, methyl (Me), -OH, -OMe, -NH2, -NHMe or -NMe2 group, wherein any methyl group of a -L78- substituent may optionally be fluoro substituted. As stated in accordance with each of the first to the fourth aspects of the invention, ring A is a phenyl or a 5- or 6-membered heteroaryl ring. For example, in accordance with the first or the second aspect of the invention, ring A may be a phenyl or a 6-membered heteroaryl ring, wherein the group R9OOC- is attached to the phenyl or the 6-membered heteroaryl ring at the 3-, 4- or 5-position, relative to the point of attachment of the phenyl or the 6-membered heteroaryl ring to the remainder of the molecule. Alternatively, ring A may be a 5-membered heteroaryl ring, wherein the group R9OOC- is attached to the 5-membered heteroaryl ring at the 3- or 4-position, relative to the point of attachment of the 5-membered heteroaryl ring to the remainder of the molecule. Similarly, in accordance with the third or the fourth aspect of the invention, ring A may be a phenyl or a 6-membered heteroaryl ring, wherein the group R19CON(R18)OOC- is attached to the phenyl or the 6-membered heteroaryl ring at the 3-, 4- or 5-position, relative to the point of attachment of the phenyl or the 6-membered heteroaryl ring to the remainder of the molecule. Alternatively, ring A may be a 5-membered heteroaryl ring, wherein the group R19CON(R18)OOC- is attached to the 5-membered heteroaryl ring at the 3- or 4-position, relative to the point of attachment of the 5-membered heteroaryl ring to the remainder of the molecule. For the avoidance of doubt, where reference is made to the point of attachment of the phenyl or the 5- or 6-membered heteroaryl ring (ring A) to the remainder of the molecule, what is referred to is the ring atom of the phenyl or the 5- or 6-membered heteroaryl ring of ring A that is directly attached to the carbon atom that in turn is directly attached to R11. Said ring atom is considered the 1-position. Typically in accordance with each of the first to the fourth aspects of the invention, ring A is a phenyl or a 6-membered heteroaryl ring. In one embodiment of the first aspect of the invention, the compound is a compound of Formula (Ia): Formula (Ia) wherein: XA1is N, C-H or C-R10; XA2is N, C-H or C-R10; XA3is N, C-H or C-R10; and XA4is N, C-H or C-R10; provided that no more than three of XA1, XA2, XA3and XA4are N; and R1to R11, X12, R13, m, n and q are as defined in accordance with Formula (I). In one embodiment of the second aspect of the invention, the compound is a compound of Formula (IIa): wherein: XA1is N, C-H or C-R10; XA2is N, C-H or C-R10; XA3is N, C-H or C-R10; and XA4is N, C-H or C-R10; provided that no more than three of XA1, XA2, XA3and XA4are N; and R1, R4to R11, X12, R13to R17, m, n and q are as defined in accordance with Formula (II). In one embodiment of the third aspect of the invention, the compound is a compound of Formula (IIIa):

[0006] wherein: XA1is N, C-H or C-R10; XA2is N, C-H or C-R10; XA3is N, C-H or C-R10; and XA4is N, C-H or C-R10; provided that no more than three of XA1, XA2, XA3and XA4are N; and R1to R8, R10, R11, X12, R13, R18, R19, m, n and q are as defined in accordance with Formula (III). In one embodiment of the fourth aspect of the invention, the compound is a compound of Formula (IVa):

[0007] wherein: XA1is N, C-H or C-R10; XA2is N, C-H or C-R10; XA3is N, C-H or C-R10; and XA4is N, C-H or C-R10; provided that no more than three of XA1, XA2, XA3and XA4are N; and R1, R4to R8, R10, R11, X12, R13to R19, m, n and q are as defined in accordance with Formula (IV). In one embodiment of any of the first to fourth aspects of the invention, no more than two of XA1, XA2, XA3and XA4are N. Typically, no more than one of XA1, XA2, XA3and XA4is N. Typically, no more than two of XA1, XA2, XA3and XA4are C-R10. More typically, no more than one of XA1, XA2, XA3and XA4is C-R10. In another embodiment of any of the first to fourth aspects of the invention, XA1is C-H or C-R10, XA2is C-H or C-R10, XA3is C-H or C-R10, and XA4is C-H or C-R10. In a further embodiment of any of the first to fourth aspects of the invention, XA1is C-H, XA2is C-H, XA3is C-H, and XA4is C-H. As stated in accordance with both the first and second aspect of the invention, R9is an aryl or a heteroaryl group, wherein the aryl or the heteroaryl group is a monocylic group or a fused bicyclic or fused tricyclic group, and wherein the aryl or the heteroaryl group may optionally be substituted with one or more substituents each independently selected from a halo, -OH, -NH2, -NO2, -SH, -SO2H, -SO3H, -SO2NH2, -R90or -SO2R90group, wherein each R90is independently selected from a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton. Typically the aryl or the heteroaryl group of R9is a monocylic group or a fused bicyclic group. In one embodiment, R9is a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more substituents each independently selected from a halo, -OH, -NH2, -NO2, -SH, -SO2H, -SO3H, -SO2NH2, -R90or -SO2R90group, wherein each R90is independently selected from a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton. In a further embodiment, R9is a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more substituents each independently selected from fluoro, chloro and bromo, and / or with one or two substituents each independently selected from a -OH, -NH2, -NO2, -SH, -SO2H, -SO3H, -SO2NH2, -R90or -SO2R90group. Typically in such an embodiment, the phenyl or the 5- or 6-membered heteroaryl group is substituted with at least one substitutent. As stated, each R90is independently selected from a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton. Typically, each R90is independently selected from a C1-C3 saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O in its carbon skeleton. In yet another embodiment, R9is a phenyl or a 6-membered heteroaryl group, such as a pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl group, wherein the phenyl or the 6- membered heteroaryl group is: (i) substituted with at least one fluoro group; and / or (ii) substituted with one or two substituents each independently selected from a fluoromethyl, fluoroethyl or -R91group, wherein each R91group is independently selected from a -NO2, -SO3H, -OR92, -CHO, -COR92, -COOH, -COOR92, -CONH2, -CONHR92, -CON(R92)2, -SO2R92, -SO2NH2, -SO2NHR92or -SO2N(R92)2 group, wherein each R92is independently selected from a methyl, ethyl, fluoromethyl or fluoroethyl group. In one aspect of such an embodiment, each R91group is independently selected from a -NO2, -SO3H, -OR92, -COR92, -COOR92, -CONH2, -CONHR92, -CON(R92)2, -SO2R92, -SO2NH2, -SO2NHR92or -SO2N(R92)2group. Typically, where the phenyl or the 6-membered heteroaryl group of R9is substituted with one or two -R91groups, each R91group is attached to the phenyl or the 6- membered heteroaryl ring at the 2-, 4- or 6-position (i.e. ortho- or para-), relative to the point of attachment of the phenyl or the 6-membered heteroaryl ring to the remainder of the molecule. In a further embodiment of the first or second aspect of the invention, R9is selected from:

[0008] In one aspect of such an embodiment, R9is selected from: or . As stated in accordance with each of the first to the fourth aspects of the invention, p is 0, 1, 2, 3 or 4. Accordingly, ring A may optionally be substituted with from one to four groups R10. Typically, p is 0, 1 or 2. More typically, p is 0 or 1. More typically still, p is 0. In one embodiment of any of the first to fourth aspects of the invention, each R10is independently selected from a halo, -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton, or any two adjacent R10may together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton. In a further embodiment, each R10is independently selected from a halo, -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton. For example, each R10may be independently selected from a fluoro, chloro, bromo, -OH, -NH2 or a C1-C4 saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton. Typically in such an embodiment, one R10(if present) is selected from a fluoro, chloro, bromo, -OH, -NH2or a C1-C4saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton, and each remaining R10(if present) is independently selected from a fluoro, chloro or bromo group. In another embodiment, one R10(if present) is selected from a fluoro, chloro, bromo, -OH or a C1-C3 saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom O in its carbon skeleton, and each remaining R10(if present) is independently selected from a fluoro, chloro or bromo group. Typically in such an embodiment, one R10(if present) is selected from a fluoro, -OH, methyl (Me), ethyl (Et), -OMe, -OEt, -CH2OH, -CH2OMe or -CH2OEt group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of R10may optionally be fluoro substituted, and each remaining R10(if present) is a fluoro group. In a further embodiment, one R10(if present) is selected from a fluoro, methyl or fluoromethyl group, and each remaining R10(if present) is a fluoro group. In another embodiment, two adjacent R10together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton. As will be understood, in such an embodiment the hydrocarbylene group together with the atoms to which it is attached forms a ring that is fused to ring A. Typically in such an embodiment, the hydrocarbylene group has a chain length of 3 or 4 atoms. In other words, typically the hydrocarbylene group together with the atoms to which it is attached forms a 5- or 6-membered ring that is fused to ring A. For example, two adjacent R10may together form a C2-C4saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group is straight-chained, wherein the hydrocarbylene group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and / or with a single methyl, fluoromethyl, methoxy or fluoromethoxy group, and wherein the hydrocarbylene group may optionally include a single heteroatom selected from N and O in its carbon skeleton, such that the hydrocarbylene group has a chain length of 3 or 4 atoms. In a further embodiment, two adjacent R10together form a -CH2-CH2-CH2-, -CH2-CH2-CH2-CH2-, -O-CH2-CH2-, -CH2-CH2-O-, -O-CH2-CH2-CH2-, -CH2-CH2-CH2-O-, -O-CH=CH-, -CH=CH-O-, -NH-CH=CH-, -CH=CH-NH-, =CH-CH=CH-, -CH=CH-CH=, =N-CH=CH-, -CH=CH-N=, -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=CH-CH=N-, -CH=N-CH=CH- or -CH=CH-N=CH- group. Typically, no more than two adjacent R10together form a hydrocarbylene group. Where two adjacent R10together form a hydrocarbylene group, such as a -CH2-CH2-CH2-, -CH2-CH2-CH2-CH2-, -O-CH2-CH2-, -CH2-CH2-O-, -O-CH2-CH2-CH2-, -CH2-CH2-CH2-O-, -O-CH=CH-, -CH=CH-O-, -NH-CH=CH-, -CH=CH-NH-, =CH-CH=CH-, -CH=CH-CH=, =N-CH=CH-, -CH=CH-N=, -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=CH-CH=N-, -CH=N-CH=CH- or -CH=CH-N=CH- group, each remaining R10(if present) may be independently selected from any other R10group as specified herein. Typically, where two adjacent R10together form a hydrocarbylene group, each remaining R10(if present) is independently selected from a fluoro, chloro or bromo group. More typically, each remaining R10(if present) is a fluoro group. As stated in accordance with each of the first to the fourth aspects of the invention, X12is NR121or C(R122)(R123). In one embodiment, X12is NR121. In a further embodiment, X12is C(R122)(R123). As stated in accordance with each of the first to the fourth aspects of the invention, m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2. In one embodiment, X12is NR121, and (i) m is 1 and n is 1, or (ii) m is 1 and n is 2, or (iii) m is 2 and n is 1. Typically in such an embodiment, m is 1 and n is 1. In another embodiment, X12is C(R122)(R123), and (i) m is 0 and n is 0, or (ii) m is 0 and n is 1, or (iii) m is 1 and n is 0, or (iv) m is 1 and n is 1, or (v) m is 1 and n is 2, or (vi) m is 2 and n is 1. Typically in such an embodiment, (i) m is 0 and n is 1, or (ii) m is 1 and n is 0, or (iii) m is 1 and n is 1. More typically in such an embodiment, m is 1 and n is 1. In one embodiment of the first aspect of the invention, where m is 1 and n is 1, the compound is a compound of Formula (Ib): wherein R1to R9, R11, X12, R13, XA1, XA2, XA3, XA4and q are as defined in accordance with Formula (Ia). In one embodiment of the second aspect of the invention, where m is 1 and n is 1, the compound is a compound of Formula (IIb):

[0009] wherein R1, R4to R9, R11, X12, R13to R17, XA1, XA2, XA3, XA4and q are as defined in accordance with Formula (IIa). In one embodiment of the third aspect of the invention, where m is 1 and n is 1, the compound is a compound of Formula (IIIb): Formula (IIIb) wherein R1to R8, R11, X12, R13, R18, R19, XA1, XA2, XA3, XA4and q are as defined in accordance with Formula (IIIa). In one embodiment of the fourth aspect of the invention, where m is 1 and n is 1, the compound is a compound of Formula (IVb):

[0010] wherein R1, R4to R8, R11, X12, R13to R19, XA1, XA2, XA3, XA4and q are as defined in accordance with Formula (IVa). As stated in accordance with each of the first to the fourth aspects of the invention, q is 0, 1, 2, 3, 4, 5, 6, 7 or 8. Typically: (i) where m is 0 and n is 0, q is 0, 1 or 2; (ii) where m is 0 and n is 1, or m is 1 and n is 0, q is 0, 1, 2, 3 or 4; (iii) where m is 1 and n is 1, or m is 0 and n is 2, or m is 2 and n is 0, q is 0, 1, 2, 3, 4, 5 or 6; and (iv) where m is 1 and n is 2, or m is 2 and n is 1, q is 0, 1, 2, 3, 4, 5, 6, 7 or 8. In one embodiment of any of the first to the fourth aspects of the invention, q is 0, 1 or 2. Typically, q is 0 or 1. More typically, q is 0. As stated, in one embodiment of any of the first to fourth aspects of the invention, R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom. Typically, where R11is a hydrocarbyl group, the hydrocarbyl group, including any optional substituents, contains no more than six carbon atoms. More typically, the hydrocarbyl group, including any optional substituents, contains no more than four carbon atoms. Typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R11, including any optional substituents, is no more than four. More typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R11, including any optional substituents, is no more than three. In another embodiment, R11is selected from hydrogen or a fluoro or a C1-C4 saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O in its carbon skeleton, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom. In a further embodiment, R11is selected from hydrogen or a fluoro, methyl (Me), ethyl (Et), -CH2OH, -CH2OMe or -CH2OEt group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of R11may optionally be fluoro substituted. Typically in such an embodiment, R11is selected from hydrogen or a fluoro group. More typically, R11is hydrogen. As stated, in one embodiment of any of the first to fourth aspects of the invention, R121is selected from hydrogen or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom. Typically, where R121is a hydrocarbyl group, the hydrocarbyl group, including any optional substituents, contains no more than six carbon atoms. More typically, the hydrocarbyl group, including any optional substituents, contains no more than four carbon atoms. Typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R121, including any optional substituents, is no more than four. More typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R121, including any optional substituents, is no more than three. In another embodiment, R121is selected from hydrogen or a -R124, -R125or -L121-R125group, wherein: R124is selected from a C1-C6 saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; R125is selected from a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more groups each independently selected from fluoro, chloro and bromo; and L121is a -CH2-, -C(=O)-, -CHMe- or -CMe2- group, wherein any -CH2-, -CHMe- or -CMe2- group may optionally be fluoro substituted; provided that any R121group, including any optional substituents, contains no more than 8 carbon atoms, and that any atom of -R124, -R125or -L121-R125that is directly attached to the reminder of the molecule is a carbon atom. Typically in such an embodiment, R121is selected from hydrogen or a -R124group. In yet another embodiment, R121is selected from hydrogen or a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group. In a further embodiment, R121is selected from a C1-C3alkyl, cyclopropyl, C1-C3fluoroalkyl or fluorocyclopropyl group. As stated, in one embodiment of any of the first to fourth aspects of the invention, R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1- C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. Typically, where R122is a hydrocarbyl group, the hydrocarbyl group, including any optional substituents, contains no more than six carbon atoms. More typically, the hydrocarbyl group, including any optional substituents, contains no more than four carbon atoms. Typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R122, including any optional substituents, is no more than four. More typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R122, including any optional substituents, is no more than three. In another embodiment, R122is selected from hydrogen or a fluoro, -OH, -NH2, -R126, -SO2R126, -R127or -L122-R127group, wherein: R126is selected from a C1-C6 saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O), -CN or -SO2Me group, wherein the -SO2Me group may optionally be fluoro substituted, and wherein the saturated hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; R127is selected from a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more groups each independently selected from fluoro, chloro and bromo, and / or with a single methyl, fluoromethyl, -CN or -SO2Me group, wherein the -SO2Me group may optionally be fluoro substituted; and L122is a -SO2-, -CH2-, -C(=O)-, -CHMe- or -CMe2- group, wherein any -CH2-, -CHMe- or -CMe2- group may optionally be fluoro substituted; provided that any R122group, including any optional substituents, contains no more than 8 carbon atoms. Typically in such an embodiment, R122is selected from hydrogen or a fluoro, -OH, -NH2 or -R126group. In a further embodiment, R122is selected from hydrogen or a fluoro, -R128or -OR128group, wherein R128is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4fluorocycloalkyl group. For example, R122may be a -OR128group, such as a -OMe or OEt group, wherein the methyl (Me) or ethyl (Et) group may optionally be fluoro substituted. In one embodiment, R122is -OEt. As stated, in one embodiment of any of the first to fourth aspects of the invention, R123is selected from hydrogen or a fluoro or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom. Typically, where R123is a hydrocarbyl group, the hydrocarbyl group, including any optional substituents, contains no more than six carbon atoms. More typically, the hydrocarbyl group, including any optional substituents, contains no more than four carbon atoms. Typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R123, including any optional substituents, is no more than four. More typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R123, including any optional substituents, is no more than three. In another embodiment, R123is selected from hydrogen or a fluoro or a C1-C4 saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O in its carbon skeleton, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom. In a further embodiment, R123is selected from hydrogen or a fluoro, C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group. For example, R123may be hydrogen or a fluoro, methyl or fluoromethyl group. In a typical embodiment, R123is hydrogen. In one embodiment of the first aspect of the invention, where X12is C(R122)(R123) and R123is hydrogen, the compound is a compound of Formula (Ic): wherein R1to R9, R11, R122, R13, XA1, XA2, XA3, XA4and q are as defined in accordance with Formula (Ia). In one embodiment of the second aspect of the invention, where X12is C(R122)(R123) and R123is hydrogen, the compound is a compound of Formula (IIc): Formula (IIc) wherein R1, R4to R9, R11, R122, R13to R17, XA1, XA2, XA3, XA4and q are as defined in accordance with Formula (IIa). In one embodiment of the third aspect of the invention, where X12is C(R122)(R123) and R123is hydrogen, the compound is a compound of Formula (IIIc): Formula (IIIc) wherein R1to R8, R11, R122, R13, R18, R19, XA1, XA2, XA3, XA4and q are as defined in accordance with Formula (IIIa). In one embodiment of the fourth aspect of the invention, where X12is C(R122)(R123) and R123is hydrogen, the compound is a compound of Formula (IVc): Formula (IVc) wherein R1, R4to R8, R11, R122, R13to R19, XA1, XA2, XA3, XA4and q are as defined in accordance with Formula (IVa). As stated, in one embodiment of any of the first to fourth aspects of the invention, each R13(if present) is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom. For example, one or two R13(if present) may be independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom, and each remaining R13(if present) may be a fluoro group. Typically, where R13is a hydrocarbyl group, the hydrocarbyl group, including any optional substituents, contains no more than six carbon atoms. More typically, the hydrocarbyl group, including any optional substituents, contains no more than four carbon atoms. Typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R13, including any optional substituents, is no more than four. More typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R13, including any optional substituents, is no more than three. In another embodiment, each R13(if present) is independently selected from selected from a fluoro, -OH, -NH2, or a C1-C4saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O in its carbon skeleton, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen or nitrogen atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom. For example, one R13(if present) may be selected from selected from a fluoro, -OH, -NH2, or a C1-C4saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O in its carbon skeleton, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen or nitrogen atom, the atom of R13 that is directly attached to the remainder of the molecule is a fluorine or carbon atom, and each remaining R13(if present) may be a fluoro group. In a further embodiment, one R13(if present) that is not directly attached to a carbon atom which in turn is directly attached to a nitrogen atom is selected from a fluoro, methyl (Me), ethyl (Et), -OH, -OMe, -OEt, -CH2OH, -CH2OMe or -CH2OEt group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of R13may optionally be fluoro substituted, or one R13(if present) that is directly attached to a carbon atom which in turn is directly attached to a nitrogen atom is selected from a fluoro, methyl (Me), ethyl (Et), -CH2OH, -CH2OMe or -CH2OEt group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of R13may optionally be fluoro substituted, and each remaining R13(if present) is a fluoro group. As stated, in one embodiment of any of the first to fourth aspects of the invention, R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1- C8saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. Typically, where R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13together form a hydrocarbylene group, the hydrocarbylene group, including any optional substituents, contains no more than six carbon atoms. More typically, the hydrocarbylene group, including any optional substituents, contains no more than four carbon atoms. Typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbylene group (including any optional substituents) formed by any of R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13is no more than four. More typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbylene group (including any optional substituents) formed by any of R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13is no more than three. In a further embodiment of any of the first to fourth aspects of the invention, R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. Typically in such embodiments, no more than one of (i) R11and R121, or (ii) R11and R122, or (iii) R11and R123, or (iv) R11and any single R13, or (v) R121and any single R13, or (vi) R122and R123, or (vii) R122and any single R13, or (viii) R123and any single R13, or (ix) any two R13, together form a hydrocarbylene group. Typically, where R11and R121, or R11and R122, or R11and R123, or R11and any R13together form a hydrocarbylene group, the atom of the hydrocarbylene group that is directly attached to the carbon atom to which ring A is attached is a carbon atom. Typically, where R11and R121, or R121and any R13, together form a hydrocarbylene group, the atom of the hydrocarbylene group that is directly attached to the nitrogen atom of NR121is a carbon atom. Typically, where R11and R123, or R123and any R13together form a hydrocarbylene group, the atom of the hydrocarbylene group that is directly attached to the carbon atom of C(R122)(R123) is a carbon atom. Where R122and R123together form a hydrocarbylene group, two atoms of the hydrocarbylene group are directly attached to the carbon atom of C(R122)(R123). Typically, at least one of the two atoms is a carbon atom. Typically, where R11and any R13, or R121and any R13, or R122and any R13, or R123and any R13, or any two R13together form a hydrocarbylene group, and the carbon atom of a CR13moiety through which the hydrocarbylene group is attached to the remainder of the molecule is in turn directly attached to an oxygen, nitrogen or sulphur atom, the atom of the hydrocarbylene group that is directly attached to the carbon atom of the CR13moiety is a carbon atom. In one embodiment of any of the first to fourth aspects of the invention, R122and R123, or any two R13attached to the same carbon atom, together form a C2-C5saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group is straight- chained, wherein the hydrocarbylene group may optionally include one or two heteroatoms each independently selected from N, O and S in its carbon skeleton, wherein any -S- moiety may optionally be substituted with one or two oxo (=O) groups to form a -SO- or -SO2- moiety, wherein the hydrocarbylene group may optionally be substituted with one or more substitutents each independently selected from a fluoro, chloro, bromo, methyl (Me), ethyl (Et), -OH, -OMe, -OEt, -CH2OH, -CH2OMe, -CH2OEt, -NH2, -NHMe, -N(Me)2, -CH2NH2, -CH2NHMe, -CH2N(Me)2, oxo (=O), -CN, -CH2-, or -COMe group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of such a substituent may optionally be fluoro substituted, and wherein the hydrocarbylene group, including any optional substituents, contains no more than 6 carbon atoms. As will be appreciated, in such an embodiment the hydrocarbylene group is attached to the remainder of the molecule as a spiro ring structure. Typically in such an embodiment, only R122and R123, or only two R13attached to the same carbon atom, together form a hydrocarbylene group. More typically in such an embodiment, only R122and R123together form a hydrocarbylene group. In a further embodiment of any of the first to fourth aspects of the invention, R122and R123together form a C2-C4saturated hydrocarbylene group, wherein the hydrocarbylene group is straight-chained, wherein the saturated hydrocarbylene group may optionally include a single heteroatom N or O in its carbon skeleton, wherein the hydrocarbylene group may optionally be substituted with one or more substitutents each independently selected from a fluoro, methyl (Me), ethyl (Et), -OH, -OMe, -OEt, -CH2OH, -CH2OMe, -CH2OEt or -COMe group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of such a substituent may optionally be fluoro substituted, and wherein the hydrocarbylene group, including any optional substituents, contains no more than 5 carbon atoms. In one embodiment of any of the first to fourth aspects of the invention, R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and any R13, or R123and any R13, or any two R13, when attached to adjacent ring atoms (e.g. adjacent ring carbon atoms or adjacent ring carbon and nitrogen atoms), together form a C1-C4saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group is straight-chained, wherein the hydrocarbylene group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton, wherein the hydrocarbylene group may optionally be substituted with one or more substitutents each independently selected from a fluoro, chloro, bromo, methyl (Me), ethyl (Et), -OH, -OMe, -OEt, -CH2OH, -CH2OMe, -CH2OEt, -NH2, -NHMe, -N(Me)2, -CH2NH2, -CH2NHMe, -CH2N(Me)2, oxo (=O), -CN, -CH2-, or -COMe group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of such a substituent may optionally be fluoro substituted, and wherein the hydrocarbylene group, including any optional substituents, contains no more than 6 carbon atoms. As will be appreciated, in such an embodiment the hydrocarbylene group is attached to the remainder of the molecule as a fused ring structure. Typically in such an embodiment, no more than one of (i) R11and R121, or (ii) R11and R122, or (iii) R11and R123, or (iv) R11and any single R13, or (v) R121and any single R13, or (vi) R122and any single R13, or (vii) R123and any single R13, or (viii) any two R13, together form a hydrocarbylene group. More typically in such an embodiment, only one of (i) R11and any single R13, or (ii) R122and any single R13, or (iii) R123and any single R13, or (iv) any two R13, together form a hydrocarbylene group. In a further embodiment of any of the first to fourth aspects of the invention, R11and any single R13, or R122and any single R13, or R123and any single R13, or any two R13, when attached to adjacent ring carbon atoms, together form a C1-C3 saturated hydrocarbylene group, wherein the hydrocarbylene group is straight-chained, wherein the saturated hydrocarbylene group may optionally include a single heteroatom N or O in its carbon skeleton, wherein the hydrocarbylene group may optionally be substituted with one or more substitutents each independently selected from a fluoro, methyl (Me), ethyl (Et), -OH, -OMe, -OEt, -CH2OH, -CH2OMe, -CH2OEt or -COMe group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of such a substituent may optionally be fluoro substituted, and wherein the hydrocarbylene group, including any optional substituents, contains no more than 5 carbon atoms. In one embodiment of any of the first to fourth aspects of the invention, R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and any R13, or R123and any R13, or any two R13, when attached to non-adjacent ring atoms (e.g. non- adjacent ring carbon atoms or non-adjacent ring carbon and nitrogen atoms), together form a C1-C4 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group is straight-chained, wherein the hydrocarbylene group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton, wherein the hydrocarbylene group may optionally be substituted with one or more substitutents each independently selected from a fluoro, chloro, bromo, methyl (Me), ethyl (Et), -OH, -OMe, -OEt, -CH2OH, -CH2OMe, -CH2OEt, -NH2, -NHMe, -N(Me)2, -CH2NH2, -CH2NHMe, -CH2N(Me)2, oxo (=O), -CN, -CH2-, or -COMe group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of such a substituent may optionally be fluoro substituted, and wherein the hydrocarbylene group, including any optional substituents, contains no more than 6 carbon atoms. As will be appreciated, in such an embodiment the hydrocarbylene group is attached to the remainder of the molecule as a bridged ring structure. Typically in such an embodiment, no more than one of (i) R11and R121, or (ii) R11and R122, or (iii) R11and R123, or (iv) R11and any single R13, or (v) R121and any single R13, or (vi) R122and any single R13, or (vii) R123and any single R13, or (viii) any two R13, together form a hydrocarbylene group. More typically in such an embodiment, only one of (i) R11and R122, or (ii) R11and R123, or (iii) R11and any single R13, or (iv) R122and any single R13, or (v) R123and any single R13, or (vi) any two R13, together form a hydrocarbylene group. In a further embodiment of any of the first to fourth aspects of the invention, R11and R122, or R11and R123, or R11and any single R13, or R122and any single R13, or R123and any single R13, or any two R13, when attached to non-adjacent ring carbon atoms, together form a C1-C3 saturated hydrocarbylene group, wherein the hydrocarbylene group is straight-chained, wherein the saturated hydrocarbylene group may optionally include a single heteroatom N or O in its carbon skeleton, wherein the hydrocarbylene group may optionally be substituted with one or more substitutents each independently selected from a fluoro, methyl (Me), ethyl (Et), -OH, -OMe, -OEt, -CH2OH, -CH2OMe, -CH2OEt or -COMe group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of such a substituent may optionally be fluoro substituted, and wherein the hydrocarbylene group, including any optional substituents, contains no more than 5 carbon atoms. As stated in accordance with the second and fourth aspects of the invention, each R14and R15is independently selected from hydrogen or a C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4 fluorocycloalkyl group, or R14and R15together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted. In one embodiment, each R14and R15is independently selected from hydrogen or a C1- C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group. For example, R14may be hydrogen and R15may be selected from hydrogen or a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group. Typically in such an embodiment, each R14and R15is independently selected from hydrogen or a C1-C3 alkyl, cyclopropyl, C1-C3fluoroalkyl or fluorocyclopropyl group. For example, R14may be hydrogen and R15may be selected from hydrogen or a C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group. More typically in such an embodiment, each R14and R15is independently selected from hydrogen or a methyl or fluoromethyl group. For example, R14may be hydrogen and R15may be selected from hydrogen or a methyl or fluoromethyl group. In one embodiment, R14and R15are both hydrogen. In another embodiment, R14and R15together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted. Typically in such an embodiment, R14and R15together with the carbon atom to which they are attached form a 3- to 5-membered saturated monocyclic group wherein the saturated monocyclic group may optionally be substituted with one or more fluoro groups and / or with one or two substituents each independently selected from oxo (=O) or a methyl or fluoromethyl group. For example, R14and R15together with the carbon atom to which they are attached may form a cyclopropyl or a cyclobutyl group, wherein the cyclopropyl or cyclobutyl group may optionally be substituted with one or more fluoro groups. As stated in accordance with the second and fourth aspects of the invention, in one embodiment R16is selected from hydrogen or a fluoro, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, and R17is selected from hydrogen or a fluoro, C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4 fluorocycloalkyl group, or R16and R17together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted. In one embodiment, R16is selected from hydrogen or a fluoro, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, and R17is selected from hydrogen or a fluoro, C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group. In one aspect of such an embodiment, R16is selected from hydrogen or a fluoro, -R160, -CN, -CHO, -COR160, -CO2H or -CO2R160group, wherein R160is selected from a C1-C6alkyl, C1-C6fluoroalkyl, C2-C6alkenyl, C2-C6fluoroalkenyl or -R161group, wherein R161is a 3- to 6-membered monocyclic group, wherein the 3- to 6-membered monocyclic group may optionally be substituted with one or more halo (e.g. fluoro, chloro or bromo) groups and / or with one or two groups R162, wherein each R162is independently selected from a methyl or a fluoromethyl group, provided that the group R16, including any optional substituents, contains no more than 8 carbon atoms. Typically in such an embodiment, R16is selected from hydrogen or a fluoro, -R160, -CN, -CHO, -COR160, -CO2H or -CO2R160group, wherein R160is selected from a C1-C4 alkyl, C1-C4 fluoroalkyl or -R161group, wherein R161is selected from a C3-C6cycloalkyl group, a 4- to 6- membered saturated heterocyclic group, or a phenyl or a 5- or 6-membered heteroaryl group, wherein the C3-C6 cycloalkyl group and the 4- to 6-membered saturated heterocyclic group may optionally be substituted with one or more fluoro groups and / or with one or two groups R162, and wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and / or with one or two groups R162, provided that the group R16, including any optional substituents, contains no more than 8 carbon atoms. More typically in such an embodiment, R16is selected from hydrogen or a fluoro, -R160, -R161, -CN, -CHO, -COR160, -CO2H or -CO2R160group, wherein R160is selected from a methyl or fluoromethyl group, and wherein R161is a 5-membered heteroaryl group, wherein the 5-membered heteroaryl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and / or with one or two groups R162. Typically in the above aspect, R17is selected from hydrogen or a fluoro, C1-C4 alkyl, C3- C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group. More typically, R17is selected from hydrogen or a fluoro, C1-C3alkyl, cyclopropyl, C1-C3fluoroalkyl or fluorocyclopropyl group. Most typically, R17is hydrogen. In another aspect of such an embodiment, R16is selected from hydrogen or a fluoro, -R160, -CN, -CHO, -COR160, -CO2H or -CO2R160group, wherein R160is selected from a C1- C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group, and R17is selected from hydrogen or a fluoro, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3- C4fluorocycloalkyl group. Typically in such an aspect, R17is selected from hydrogen or a fluoro, C1-C3alkyl, cyclopropyl, C1-C3fluoroalkyl or fluorocyclopropyl group. For example, R16may be selected from hydrogen or a fluoro, -R160, -CN, -CHO, -COR160, -CO2H or -CO2R160group, wherein R160is selected from a methyl or fluoromethyl group, and R17may be hydrogen. In a further aspect of such an embodiment, R16is selected from hydrogen or a fluoro, -CN, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group, and R17is selected from hydrogen or a fluoro, C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group, or R16and R17together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted. In one embodiment, R16is selected from hydrogen or a fluoro, -CN, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group, and R17is selected from hydrogen or a fluoro, C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group. For example, R16may be selected from hydrogen or a fluoro, -CN, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group, and R17may be hydrogen. Typically in such an embodiment, R16is selected from hydrogen or a fluoro, -CN, C1-C3alkyl, cyclopropyl, C1-C3fluoroalkyl or fluorocyclopropyl group, and R17is selected from hydrogen or a fluoro, C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group. For example, R16may be selected from hydrogen or a fluoro, -CN, C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group, and R17may be hydrogen. More typically in such an embodiment, each R16and R17is independently selected from hydrogen or a methyl or fluoromethyl group. For example, R16may be selected from hydrogen or a methyl or fluoromethyl group and R17may be hydrogen. In one embodiment, R16and R17are both hydrogen. In another embodiment, R16and R17together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted. Typically in such an embodiment, R16and R17together with the carbon atom to which they are attached form a 3- to 5-membered saturated monocyclic group wherein the saturated monocyclic group may optionally be substituted with one or more fluoro groups and / or with one or two substituents each independently selected from oxo (=O) or a methyl or fluoromethyl group. For example, R16and R17together with the carbon atom to which they are attached may form a cyclopropyl or a cyclobutyl group, wherein the cyclopropyl or cyclobutyl group may optionally be substituted with one or more fluoro groups. In one embodiment of the second and fourth aspects of the invention: R16is selected from hydrogen or a fluoro, -CN, C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group; and R17is selected from hydrogen or a fluoro, C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group; or R16and R17together with the carbon atom to which they are attached form a cyclopropyl or a cyclobutyl group, wherein the cyclopropyl or cyclobutyl group may optionally be substituted with one or more fluoro groups. As stated in accordance with the first and third aspects of the invention, in one embodiment R3and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. In a corresponding embodiment of the second and fourth aspects of the invention, R17and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. Typically, where R3and R7, or R17and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13together form a hydrocarbylene group, the hydrocarbylene group, including any optional substituents, contains no more than ten carbon atoms. Typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbylene group (including any optional substituents) formed by any of R3and R7, or R17and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13is no more than five. More typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbylene group (including any optional substituents) formed by any of R3and R7, or R17and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13is no more than four. In one embodiment of the first and third aspects of the invention, R3and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C10 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one, two, three, four or five heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. In a corresponding embodiment of the second and fourth aspects of the invention, R17and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C10saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one, two, three, four or five heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. Typically in such embodiments, no more than one of (i) R3and R7, or (ii) R4and R7, or (iii) R4and any R10, or (iv) R4and any R101, or (v) R4and R11, or (vi) R4and R121, or (vii) R4and R122, or (viii) R4and R123, or (ix) R4and any R13, or (x) R7and any R10, or (xi) R7and any R101, or (xii) R7and R11, or (xiii) R7and R121, or (xiv) R7and R122, or (xv) R7and R123, or (xvi) R7and any R13, or (xvii) any R10and R11, or (xviii) any R10and R121, or (xix) any R10and R122, or (xx) any R10and R123, or (xxi) any R10and any R13, or (xxii) any R101and R11, or (xxiii) any R101and R121, or (xxiv) any R101and R122, or (xxv) any R101and R123, or (xxvi) any R101and any R13, or (xxvii) R17and R7, together form a hydrocarbylene group. Typically, where R3and R7, or R4and R7, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or R17and R7together form a hydrocarbylene group, the atom of the hydrocarbylene group that is directly attached to the carbon atom to which R8is attached is a carbon atom. Typically, where R4and R11, or R7and R11, or any R10and R11, or any R101and R11together form a hydrocarbylene group, the atom of the hydrocarbylene group that is directly attached to the carbon atom to which ring A is attached is a carbon atom. Typically, where R4and R121, or R7and R121, or any R10and R121, or any R101and R121together form a hydrocarbylene group, the atom of the hydrocarbylene group that is directly attached to the nitrogen atom of NR121is a carbon atom. Typically, where R4and R123, or R7and R123, or any R10and R123, or any R101and R123together form a hydrocarbylene group, the atom of the hydrocarbylene group that is directly attached to the carbon atom of C(R122)(R123) is a carbon atom. Typically, where R4and any R13, or R7and any R13, or any R10and any R13, or any R101and any R13together form a hydrocarbylene group, and the carbon atom of the CR13moiety through which the hydrocarbylene group is attached to the remainder of the molecule is in turn directly attached to an oxygen, nitrogen or sulphur atom, the atom of the hydrocarbylene group that is directly attached to the carbon atom of the CR13moiety is a carbon atom. In one embodiment of the first and third aspects of the invention, R3and R7together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more (e.g. one, two or three) heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of the hydrocarbylene group that is directly attached to the carbon atom to which R8is attached is a carbon atom. In a corresponding embodiment of the second and fourth aspects of the invention, R17and R7together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more (e.g. one, two or three) heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of the hydrocarbylene group that is directly attached to the carbon atom to which R8is attached is a carbon atom. Typically in such embodiments, R3and R7, or R17and R7, together form a C1-C4saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbylene group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton, provided that the atom of the hydrocarbylene group that is directly attached to the carbon atom to which R8is attached is a carbon atom. Where R3and R7, or R17and R7, together form a hydrocarbylene group, typically the hydrocarbylene group has a chain length of from 1 to 3 atoms. More typically, the hydrocarbylene group has a chain length of 1 or 2 atoms. More typically, where R3and R7, or R17and R7, together form a hydrocarbylene group, the hydrocarbylene group is selected from -CH2-, -CH2-CH2-, -CH=CH-, -CH2-O-, or -O-CH2-, provided that the atom of the hydrocarbylene group that is directly attached to the carbon atom to which R8is attached is a carbon atom. Typically, where R3and R7, or R17and R7, together form a hydrocarbylene group, R8is selected from hydrogen or a fluoro, C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3- C4fluorocycloalkyl group. More typically, where R3and R7, or R17and R7, together form a hydrocarbylene group, R8is selected from hydrogen or a fluoro, methyl or fluoromethyl group. More typically still, where R3and R7, or R17and R7, together form a hydrocarbylene group, R8is hydrogen. Typically, where R17and R7together form a hydrocarbylene group, R16is selected from hydrogen or a fluoro, -CN, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group. More typically, where R17and R7together form a hydrocarbylene group, R16is selected from hydrogen or a fluoro, -CN, C1-C3alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group. More typically still, where R17and R7together form a hydrocarbylene group, R16is selected from hydrogen or a methyl or fluoromethyl group. Yet more typically, where R17and R7together form a hydrocarbylene group, R16is hydrogen. In one embodiment of any of the first to fourth aspects of the invention, R4and R7together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more (e.g. one, two or three) heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of the hydrocarbylene group that is directly attached to the carbon atom to which R8is attached is a carbon atom. Typically in such an embodiment, R4and R7together form a C1-C4 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbylene group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton, provided that the atom of the hydrocarbylene group that is directly attached to the carbon atom to which R8is attached is a carbon atom. Where R4and R7together form a hydrocarbylene group, typically the hydrocarbylene group has a chain length of from 2 to 4 atoms. More typically, the hydrocarbylene group has a chain length of 2 or 3 atoms. More typically, where R4and R7together form a hydrocarbylene group, the hydrocarbylene group is selected from -CH2-CH2-, -CH2-O-, -O-CH2-, -CH2-CH2-CH2-, -O-CH2-CH2-, -CH2-CH2-O- or -CH2-O-CH2-, provided that the atom of the hydrocarbylene group that is directly attached to the carbon atom to which R8is attached is a carbon atom. Typically, where R4and R7together form a hydrocarbylene group, R8is selected from hydrogen or a fluoro, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group. More typically, where R4and R7together form a hydrocarbylene group, R8is selected from hydrogen or a fluoro, methyl or fluoromethyl group. More typically still, where R4and R7together form a hydrocarbylene group, R8is hydrogen. In one embodiment of any of the first to fourth aspects of the invention, one R10and R11together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more (e.g. one, two or three) heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of the hydrocarbylene group that is directly attached to the carbon atom to which ring A is attached is a carbon atom. Typically in such an embodiment, one R10and R11together form a C1-C4saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbylene group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton, provided that the atom of the hydrocarbylene group that is directly attached to the carbon atom to which ring A is attached is a carbon atom. Where one R10and R11together form a hydrocarbylene group, typically the hydrocarbylene group has a chain length of from 2 to 4 atoms. More typically, the hydrocarbylene group has a chain length of 2 or 3 atoms. More typically, where one R10and R11together form a hydrocarbylene group, the hydrocarbylene group is selected from -CH2-CH2-, -CH2-O-, -O-CH2-, -CH2-CH2-CH2-, -O-CH2-CH2-, -CH2-CH2-O- or -CH2-O-CH2-, provided that the atom of the hydrocarbylene group that is directly attached to the carbon atom to which ring A is attached is a carbon atom. Typically, where ring A is a phenyl or a 6-membered heteroaryl ring, and one R10and R11together form a hydrocarbylene group, the R10that forms part of the hydrocarbylene group is attached to the phenyl or the 6-membered heteroaryl ring at the 2- or the 6- position, relative to the point of attachment of the phenyl or the 6-membered heteroaryl ring to the remainder of the molecule. Typically, where ring A is a 5-membered heteroaryl ring, and one R10and R11together form a hydrocarbylene group, the R10that forms part of the hydrocarbylene group is attached to the 5-membered heteroaryl ring at the 2- or the 5-position, relative to the point of attachment of the 5-membered heteroaryl ring to the remainder of the molecule. In a further embodiment of any of the first to fourth aspects of the invention, R4and R7, or R4and one R10, or R4and one R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and one R13, or R7and one R10, or R7and one R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and one R13, or one R10and R121, or one R10and R122, or one R10and R123, or one R10and one R13, or one R101and R11, or one R101and R121, or one R101and R122, or one R101and R123, or one R101and one R13, together form a C5-C10 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more (e.g. one, two, three, four or five) heteroatoms each independently selected from N, O and S in its carbon skeleton, wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, and wherein the hydrocarbylene group has a chain length of from 5 to 12 atoms. Typically in such an embodiment, R4and R7, or R4and one R10, or R4and one R101, or R4and R122, or R4and R123, or R7and one R10, or R7and one R101, or R7and R122, or R7and R123, or one R10and R122, or one R10and R123, or one R101and R122, or one R101and R123, together form the C5-C10saturated or unsaturated hydrocarbylene group. In a further embodiment of any of the first to fourth aspects of the invention, R4and R7, or R4and one R10, or R4and one R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and one R13, or R7and one R10, or R7and one R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and one R13, or one R10and R121, or one R10and R122, or one R10and R123, or one R10and one R13, or one R101and R11, or one R101and R121, or one R101and R122, or one R101and R123, or one R101and one R13, together form a -XM1-XM2-XM3- or -XM3-XM2-XM1- group, wherein -XM1- is a bond, -O-, -NH-, -NHCO- or -NHSO2- group, -XM2- is a C5-C10 straight-chained alkylene or alkenylene group, wherein the alkylene or alkenylene group may optionally be fluoro substituted, and -XM3- is a bond or a -O- group. Typically in such an embodiment, R4and R7, or R4and one R10, or R4and one R101, or R4and R122, or R4and R123, or R7and one R10, or R7and one R101, or R7and R122, or R7and R123, or one R10and R122, or one R10and R123, or one R101and R122, or one R101and R123, together form the -XM1-XM2-XM3- or -XM3-XM2-XM1- group. As stated, in one embodiment of the third or the fourth aspects of the invention, R18is selected from hydrogen or a C1-C10saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R18that is directly attached to the reminder of the molecule is a carbon atom. Typically, where R18is a hydrocarbyl group, the hydrocarbyl group, including any optional substituents, contains no more than eight carbon atoms. More typically, the hydrocarbyl group, including any optional substituents, contains no more than six carbon atoms. Typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R18, including any optional substituents, is no more than five. More typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R18, including any optional substituents, is no more than three. In a further embodiment, R18is selected from hydrogen or a -R181or -COR181group, wherein R181is a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbyl group may optionally include one, two, three or four heteroatoms each independently selected from N and O in its carbon skeleton, provided that where R18is -R181, the atom of the hydrocarbyl group of R181that is directly attached to the reminder of the molecule is a carbon atom. In one embodiment of the third or the fourth aspects of the invention, R18is a -COR181group. In a further embodiment of the third or the fourth aspects of the invention, R18is hydrogen. As stated, in one embodiment of the third or the fourth aspects of the invention, R19is selected from a C1-C10saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. Typically, where R19is a hydrocarbyl group, the hydrocarbyl group, including any optional substituents, contains no more than eight carbon atoms. More typically, the hydrocarbyl group, including any optional substituents, contains no more than six carbon atoms. Typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R19, including any optional substituents, is no more than five. More typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbyl group of R19, including any optional substituents, is no more than three. In a further embodiment of the third or the fourth aspects of the invention, R19is a C1- C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbyl group may optionally include one, two, three or four heteroatoms each independently selected from N and O in its carbon skeleton. In one embodiment of the third or the fourth aspects of the invention, R19is an aryl or a heteroaryl group, wherein the aryl or the heteroaryl group is a monocylic group or a fused bicyclic or fused tricyclic group, and wherein the aryl or the heteroaryl group may optionally be substituted with one or more substituents each independently selected from a halo, -OH, -NH2, -NO2, -SH, -SO2H, -SO3H, -SO2NH2, -R191or -SO2R191group, wherein each R191is independently selected from a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton, provided that R19, including any optional substituents, contains no more than 10 carbon atoms. Typically in such an embodiment, the aryl or the heteroaryl group is a monocylic group or a fused bicyclic group. In one embodiment, R19is a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more substituents each independently selected from a halo, -OH, -NH2, -NO2, -SH, -SO2H, -SO3H, -SO2NH2, -R191or -SO2R191group, wherein each R191is independently selected from a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton, provided that R19, including any optional substituents, contains no more than 10 carbon atoms. In a further embodiment, R19is a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more substituents each independently selected from fluoro, chloro and bromo, and / or with one or two substituents each independently selected from a -OH, -NH2, -NO2, -SH, -SO2H, -SO3H, -SO2NH2, -R191or -SO2R191group, provided that R19, including any optional substituents, contains no more than 10 carbon atoms. Typically in such an embodiment, R19is a phenyl or a 6-membered heteroaryl group, such as a pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl group. As stated, each R191is independently selected from a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton. Typically, each R191is independently selected from a C1- C3 saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O in its carbon skeleton. Typically, where R19is an aryl or a heteroaryl group, such as a phenyl or a 5- or 6- membered heteroaryl group, R19, including any optional substituents, contains no more than eight carbon atoms. More typically, where R19is an aryl or a heteroaryl group, R19, including any optional substituents, contains no more than six carbon atoms. In one embodiment, R19is: . In another embodiment of the third or the fourth aspects of the invention, R18and R19together form a C1-C10saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. Typically, where R18and R19together form a hydrocarbylene group, the hydrocarbylene group, including any optional substituents, contains no more than eight carbon atoms. More typically, the hydrocarbylene group, including any optional substituents, contains no more than six carbon atoms. Typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbylene group formed by R18and R19, including any optional substituents, is no more than five. More typically, the total number of nitrogen, oxygen and sulphur atoms in any hydrocarbylene group formed by R18and R19, including any optional substituents, is no more than three. In a further embodiment of the third or the fourth aspects of the invention, R18and R19together form a group -L189-, wherein -L189- is a C2-C4 straight chained alkylene or alkenylene group, wherein the alkylene or alkenylene group may optionally include a nitrogen atom in its carbon skeleton, wherein the alkylene or alkenylene group has a chain length of 3 or 4 atoms, and wherein the alkylene or alkenylene group may optionally be substituted with one or more groups -R189, wherein each R189is independently selected from a fluoro, chloro, bromo, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, -R190or -SO2R190group, wherein each R190is independently selected from a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton, and / or any two R189attached to the same carbon atom may together form an oxo (=O) group, and / or any two R189attached to the same or different atoms may together with the atom or atoms to which they are attached form a 3- to 7-membered cyclic group, wherein the 3- to 7-membered cyclic group may optionally be substituted with one or more groups each independently selected from a fluoro, chloro, bromo, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, -R190or -SO2R190group, provided that -L189-, including any optional substituents, contains no more than 10 carbon atoms. Typically, -L189-, including any optional substituents, contains no more than eight carbon atoms. More typically, -L189-, including any optional substituents, contains no more than six carbon atoms. In one embodiment of the third or the fourth aspects of the invention, the group R19CON(R18)- has the formula (V): Formula (V) wherein each XVis independently selected from N, C-H, C-Hal or C-R183, wherein each Hal is independently selected from a fluoro, chloro or bromo group, and wherein each R183is independently selected from a -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, -R193or -SO2R193group, wherein each R193is independently selected from a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton, and / or any two R183attached to adjacent carbon atoms may, together with atoms to which they are attached, form a 5- or 6-membered fused cyclic group, wherein the 5- or 6-membered fused cyclic group may optionally be substituted with one or more groups each independently selected from a fluoro, chloro, bromo, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, -R193or -SO2R193group, provided that no more than two XVare N, and provided that the group of Formula (V), including any optional substituents, contains no more than 10 carbon atoms. Typically, no more than one XVis N. In one embodiment, each XVis independently selected from C-H or C-R189. Typically, no more than two XVare C-R183. In one embodiment, no more than one XVis N, no more than two XVare C-R183, and each R183is independently selected from a -OH, -NH2or -R193group, wherein each R193is independently selected from a C1-C3saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O in its carbon skeleton, or any two R183attached to adjacent carbon atoms may, together with atoms to which they are attached, form a 5- or 6-membered fused cyclic group, wherein the 5- or 6-membered fused cyclic group may optionally be substituted with one or more fluoro, chloro and / or bromo groups and / or with a single -OH, -NH2 or -R193group, provided that the group of Formula (V), including any optional substituents, contains no more than 10 carbon atoms. Typically, the group of Formula (V), including any optional substituents, contains no more than eight carbon atoms. More typically, the group of Formula (V), including any optional substituents, contains no more than six carbon atoms. In one embodiment of the third or the fourth aspects of the invention, the group R19CON(R18)- has the formula (Va): Formula (Va) In another embodiment of the third or the fourth aspects of the invention, the group R19CON(R18)- has the formula (VI): Formula (VI) wherein: is a single or double bond; where is a single bond, t is 0, 1, 2, 3 or 4; where is a double bond, t is 0, 1 or 2; and each R185is independently selected from a fluoro, chloro, bromo, -SO3H, -SO2NH2, -R195or -SO2R195group, and / or any two R185attached to the same or different carbon atoms may, together with carbon atom or atoms to which they are attached, form a 3- to 7-membered spiro or fused cyclic group, wherein the 3- to 7-membered spiro or fused cyclic group may optionally be substituted with one or more groups each independently selected from a fluoro, chloro, bromo, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, -R195or -SO2R195group; and each R195is independently selected from a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; provided that the group of Formula (VI), including any optional substituents, contains no more than 10 carbon atoms. Typically, where is a single bond, t is 0, 1 or 2. In one embodiment: t is o, 1 or 2; each R185is independently selected from a fluoro, -SO3H, -R196, -OR196or -SO2R196group, provided that no more than one -SO3H, -OR196or -SO2R196group is present, or two R185attached to adjacent carbon atoms may, together with carbon atoms to which they are attached, form a 5- to 7-membered fused cyclic group, wherein the 5- to 7-membered fused cyclic group may optionally be substituted with one or more fluoro groups and / or with one or two substituents each independently selected from a -SO3H, -R196, -OR196or -SO2R196group, provided that no more than one -SO3H, -OR196or -SO2R196group is present; and each R196is independently selected from a C1-C3alkyl, cyclopropyl, C1-C4fluoroalkyl or fluorocyclopropyl group; provided that the group of Formula (VI), including any optional substituents, contains no more than 10 carbon atoms. Typically, the group of Formula (VI), including any optional substituents, contains no more than eight carbon atoms. More typically, the group of Formula (VI), including any optional substituents, contains no more than six carbon atoms. In one embodiment of the third or the fourth aspects of the invention, the group R19CON(R18)- of Formula (VI) is selected from: In a further embodiment of the third or the fourth aspects of the invention, the group R19CON(R18)- of Formula (VI) is selected from: . As will be understood, insofar as practical, embodiments directed to one substituent or moiety (such as a given R or X group) may be read in conjunction with embodiments directed to a different substituent or moiety. For example, in a first exemplary embodiment, there is provided a compound of Formula (I) as defined above, wherein: R1is hydrogen; R2is selected from hydrogen or a halo group; R3is selected from hydrogen or a halo, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 6-membered heteroaryl ring, wherein the group R9OOC- is attached to the phenyl or the 6-membered heteroaryl ring at the 3-, 4- or 5-position, relative to the point of attachment of the phenyl or the 6-membered heteroaryl ring to the remainder of the molecule, or ring A is a 5-membered heteroaryl ring, wherein the group R9OOC- is attached to the 5-membered heteroaryl ring at the 3- or 4-position, relative to the point of attachment of the 5-membered heteroaryl ring to the remainder of the molecule; R9is an aryl or a heteroaryl group, wherein the aryl or the heteroaryl group is a monocylic group or a fused bicyclic or fused tricyclic group, and wherein the aryl or the heteroaryl group may optionally be substituted with one or more substituents each independently selected from a halo, -OH, -NH2, -NO2, -SH, -SO2H, -SO3H, -SO2NH2, -R90or -SO2R90group, wherein each R90is independently selected from a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; and each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. In one aspect of the first exemplary embodiment: R3is selected from hydrogen or a halo, -CN, C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4 fluorocycloalkyl group; and R7and R8are each independently selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton. In a corresponding second exemplary embodiment, there is provided a compound of Formula (II) as defined above, wherein: R1is hydrogen; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 6-membered heteroaryl ring, wherein the group R9OOC- is attached to the phenyl or the 6-membered heteroaryl ring at the 3-, 4- or 5-position, relative to the point of attachment of the phenyl or the 6-membered heteroaryl ring to the remainder of the molecule, or ring A is a 5-membered heteroaryl ring, wherein the group R9OOC- is attached to the 5-membered heteroaryl ring at the 3- or 4-position, relative to the point of attachment of the 5-membered heteroaryl ring to the remainder of the molecule; R9is an aryl or a heteroaryl group, wherein the aryl or the heteroaryl group is a monocylic group or a fused bicyclic or fused tricyclic group, and wherein the aryl or the heteroaryl group may optionally be substituted with one or more substituents each independently selected from a halo, -OH, -NH2, -NO2 -SH, -SO2H, -SO3H, -SO2NH2, -R90or -SO2R90group, wherein each R90is independently selected from a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; each R14and R15is independently selected from hydrogen or a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group, or R14and R15together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; R16is selected from hydrogen or a fluoro, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; and R17is selected from hydrogen or a fluoro, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; or R16and R17together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted. In one aspect of the second exemplary embodiment: R7and R8are each independently selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; R16is selected from hydrogen or a fluoro, -CN, C1-C4 alkyl, C3-C4 cycloalkyl, C1- C4fluoroalkyl or C3-C4fluorocycloalkyl group; and R17is selected from hydrogen or a fluoro, C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4 fluorocycloalkyl group; or R16and R17together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted. In a third exemplary embodiment, there is provided a compound of Formula (III) as defined above, wherein: R1is hydrogen; R2is selected from hydrogen or a halo group; R3is selected from hydrogen or a halo, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 6-membered heteroaryl ring, wherein the group R19CON(R18)OOC- is attached to the phenyl or the 6-membered heteroaryl ring at the 3-, 4- or 5-position, relative to the point of attachment of the phenyl or the 6-membered heteroaryl ring to the remainder of the molecule, or ring A is a 5-membered heteroaryl ring, wherein the group R19CON(R18)OOC- is attached to the 5-membered heteroaryl ring at the 3- or 4-position, relative to the point of attachment of the 5-membered heteroaryl ring to the remainder of the molecule; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R18is selected from hydrogen or a C1-C10saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R18that is directly attached to the reminder of the molecule is a carbon atom; and R19is selected from a C1-C10 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R18and R19may together form a C1-C10 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. In one aspect of the third exemplary embodiment: R3is selected from hydrogen or a halo, -CN, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; and R7and R8are each independently selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton. In a corresponding fourth exemplary embodiment, there is provided a compound of Formula (IV) as defined above, wherein: R1is hydrogen; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 6-membered heteroaryl ring, wherein the group R19CON(R18)OOC- is attached to the phenyl or the 6-membered heteroaryl ring at the 3-, 4- or 5-position, relative to the point of attachment of the phenyl or the 6-membered heteroaryl ring to the remainder of the molecule, or ring A is a 5-membered heteroaryl ring, wherein the group R19CON(R18)OOC- is attached to the 5-membered heteroaryl ring at the 3- or 4-position, relative to the point of attachment of the 5-membered heteroaryl ring to the remainder of the molecule; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; each R14and R15is independently selected from hydrogen or a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group, or R14and R15together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; R16is selected from hydrogen or a fluoro, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R17is selected from hydrogen or a fluoro, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; or R16and R17together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; R18is selected from hydrogen or a C1-C10saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R18that is directly attached to the reminder of the molecule is a carbon atom; and R19is selected from a C1-C10 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R18and R19may together form a C1-C10 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety. In one aspect of the fourth exemplary embodiment: R7and R8are each independently selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; R16is selected from hydrogen or a fluoro, -CN, C1-C4 alkyl, C3-C4 cycloalkyl, C1- C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; and R17is selected from hydrogen or a fluoro, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4fluorocycloalkyl group; or R16and R17together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted. In a fifth exemplary embodiment, there is provided a compound of Formula (Ia) as defined above, wherein: R1is hydrogen; R2is selected from hydrogen or a fluoro, chloro or bromo group; R3is selected from hydrogen or a fluoro, chloro, bromo, -R30, -CN, -CHO, -COR30, -CO2H or -CO2R30group, provided that R3, including any optional substituents, contains no more than 8 carbon atoms; R30is selected from a C1-C6 alkyl, C1-C6 fluoroalkyl, C2-C6 alkenyl, C2-C6 fluoroalkenyl or -R31group; R31is a 3- to 6-membered monocyclic group, wherein the 3- to 6-membered monocyclic group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and / or with one or two groups R32; each R32is independently selected from a methyl or a fluoromethyl group; R4is selected from a fluoro, chloro, bromo, -OH, -OR41, -N(R42)2, -SO2-R41, -SO2-N(R42)2, -L4-OH, -L4-OR41, -L4-N(R42)2, -L4-SO2-R41, -L4-SO2-N(R42)2, -O-L4-OH, -O-L4-OR41, -O-L4-N(R42)2, -O-L4-SO2-R41, -O-L4-SO2-N(R42)2, -NR43-L4-OH, -NR43-L4-OR41, -NR43-L4-N(R42)2, -NR43-L4-SO2-R41, -NR43-L4-SO2-N(R42)2, -SO2-L4-OH, -SO2-L4-OR41, -SO2-L4-N(R42)2, -R44, -R45or -L4-R45group, provided that R4, including any optional substituents, contains no more than 8 carbon atoms; R41is selected from a -R44or -R45group; each R42is independently selected from hydrogen or a -R44or -R45group, or any two R42may, together with the nitrogen atom to which they are attached, form a 3- to 6-membered saturated monocyclic heterocyclic group, wherein the 3- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or two oxo (=O) groups and / or with one or more fluoro, methyl and / or fluoromethyl groups; L4is a straight-chained alkylene group, wherein the straight-chained alkylene group optionally includes one or two heteroatoms each independently selected from O and N in its carbon skeleton, wherein L4has a chain length of from 1 to 4 atoms, and wherein L4may optionally be substituted with one or two oxo (=O) groups and / or with one or more groups RL4; each RL4is independently selected from a fluoro, methyl or fluoromethyl group; or any RL4and R41, or any RL4and any R42, may together with the atoms to which they are attached, form a 3- to 6-membered saturated monocyclic heterocyclic group, wherein the 3- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or two oxo (=O) groups and / or with one or more fluoro, methyl and / or fluoromethyl groups; R43is selected from hydrogen or a -R44group; each R44is independently selected from a C1-C4alkyl or C3-C6cycloalkyl group, wherein the C1-C4 alkyl or C3-C6 cycloalkyl group may optionally be substituted with one or more fluoro groups and / or one or two oxo (=O) groups; each R45is independently selected from a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more groups each independently selected from fluoro, chloro and bromo, and / or with one or two groups each independently selected from methyl (Me), -CN, -OH, -OMe, -NH2, -NHMe, and -NMe2, wherein any methyl group of R45may optionally be fluoro substituted; R5is selected from hydrogen or a fluoro, chloro or bromo group; R6is selected from a chloro, bromo, -R60or -OR60group; R60is selected from a C1-C3alkyl, cyclopropyl, C1-C3fluoroalkyl or fluorocyclopropyl group; R7is selected from hydrogen or a fluoro, -CN, -COOH, -COOR71, -CO-N(R72)2, -L7-COOH, -L7-COOR71, -L7-CO-N(R72)2, -L7-OH, -L7-OR71, -L7-N(R72)2, -R73, -R74or -L7-R74group, provided that R7, including any optional substituents, contains no more than 10 carbon atoms, and that the atom of R7that is directly attached to the reminder of the molecule is a carbon, hydrogen or fluorine atom; R71is selected from a -R73or -R74group; each R72is independently selected from hydrogen or a -R73or -R74group, or any two R72may, together with the nitrogen atom to which they are attached, form a 3- to 6- membered saturated monocyclic heterocyclic group, wherein the 3- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or two oxo (=O) groups and / or with one or more fluoro, methyl and / or fluoromethyl groups; L7is selected from a straight-chained alkylene or alkenylene group, wherein the straight-chained alkylene or alkenylene group optionally includes one or two heteroatoms each independently selected from O and N in its carbon skeleton, wherein L7has a chain length of from 1 to 4 atoms, and wherein L7may optionally be substituted with one or two oxo (=O) groups and / or with one or more groups RL7; ea...

Claims

Claims 1. A compound of Formula (I):o u a ( ) or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof; wherein: R1is hydrogen; R2is selected from hydrogen or a halo group; R3is selected from hydrogen or a halo, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independentlyselected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2or a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 5- or 6-membered heteroaryl ring; R9is an aryl or a heteroaryl group, wherein the aryl or the heteroaryl group is a monocylic group or a fused bicyclic or fused tricyclic group, and wherein the aryl or the heteroaryl group may optionally be substituted with one or more substituents each independently selected from a halo, -OH, -NH2, -NO2, -SH, -SO2H, -SO3H, -SO2NH2, -R90or -SO2R90group, wherein each R90is independently selected from a C1-C4saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein thehydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted withone or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13maytogether form a C1-C8saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R3and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety.

2. A compound as claimed in claim 1, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein the compound has the Formula (Ia):wherein: XA1is N, C-H or C-R10; XA2is N, C-H or C-R10; XA3is N, C-H or C-R10; and XA1is N, C-H or C-R10; provided that no more than three of XA1, XA2, XA3and XA4are N; and R1to R11, X12, R13, m, n and q are as defined in accordance with claim 1.

3. A compound as claimed in claim 1 or claim 2, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein R2is selected from hydrogen or a fluoro, chloro or bromo group.

4. A compound as claimed in any one of claims 1 to 3, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein R3is selected from hydrogen or a fluoro, chloro, bromo, -R30, -CN, -CHO, -COR30, -CO2H or -CO2R30group, wherein R30is selected from a C1-C6alkyl, C1-C6fluoroalkyl, C2-C6alkenyl, C2-C6fluoroalkenyl or -R31group, wherein R31is a 3- to 6-membered monocyclic group, wherein the 3- to 6-membered monocyclic group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and / or with one or two groups R32, wherein each R32is independently selected from a methyl or a fluoromethyl group, provided that the group R3, including any optional substituents, contains no more than 8 carbon atoms.

5. A compound of Formula (II):Formula (II) or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof; wherein: R1is hydrogen; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independentlyselected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 5- or 6-membered heteroaryl ring; R9is an aryl or a heteroaryl group, wherein the aryl or the heteroaryl group is a monocylic group or a fused bicyclic or fused tricyclic group, and wherein the aryl or the heteroaryl group may optionally be substituted with one or more substituents each independently selected from a halo, -OH, -NH2, -NO2 -SH, -SO2H, -SO3H, -SO2NH2, -R90or -SO2R90group, wherein each R90is independently selected from a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group mayoptionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained orbranched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; each R14and R15is independently selected from hydrogen or a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group, or R14and R15together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted;R16is selected from hydrogen or a fluoro, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R17is selected from hydrogen or a fluoro, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; or R16and R17together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; or R17and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety.

6. A compound as claimed in claim 5, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein the compound has the Formula (IIa):wherein: XA1is N, C-H or C-R10; XA2is N, C-H or C-R10; XA3is N, C-H or C-R10; and XA4is N, C-H or C-R10; provided that no more than three of XA1, XA2, XA3and XA4are N; and R1, R4to R11, X12, R13to R17, m, n and q are as defined in accordance with claim 5.

7. A compound as claimed in claim 5 or claim 6, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein each R14and R15is independently selected from hydrogen or a C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group, or R14and R15together with the carbon atom to which they are attached form a cyclopropyl or a cyclobutyl group, wherein the cyclopropyl or cyclobutyl group may optionally be substituted with one or more fluoro groups.

8. A compound as claimed in any one of claims 5 to 7, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein: R16is selected from hydrogen or a fluoro, -R160, -CN, -CHO, -COR160, -CO2H or -CO2R160group, provided that R16, including any optional substituents, contains no more than 8 carbon atoms; R160is selected from a C1-C6alkyl, C1-C6fluoroalkyl, C2-C6alkenyl, C2-C6fluoroalkenyl or -R161group;R161is a 3- to 6-membered monocyclic group, wherein the 3- to 6-membered monocyclic group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and / or with one or two groups R162; each R162is independently selected from a methyl or a fluoromethyl group; and R17is selected from hydrogen or a fluoro, C1-C3alkyl, cyclopropyl, C1-C3fluoroalkyl or fluorocyclopropyl group; or R16and R17together with the carbon atom to which they are attached form a 3- to 5-membered saturated monocyclic group, wherein the saturated monocyclic group may optionally be substituted with one or more fluoro groups and / or one or two substituents each independently selected from oxo (=O) or a methyl or fluoromethyl group.

9. A compound as claimed in any one of claims 1 to 8, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein: R9is a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more substituents each independently selected from fluoro, chloro and bromo, and / or with one or two substituents each independently selected from a -OH, -NH2, -NO2, -SH, -SO2H, -SO3H, -SO2NH2, -R90or -SO2R90group; and each R90is independently selected from a C1-C3saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O in its carbon skeleton.

10. A compound of Formula (III):Formula (III) or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof; wherein: R1is hydrogen; R2is selected from hydrogen or a halo group; R3is selected from hydrogen or a halo, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group;R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 5- or 6-membered heteroaryl ring; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group mayoptionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R11is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained orbranched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R3and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12saturated orunsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R18is selected from hydrogen or a C1-C10saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R18that is directly attached to the reminder of the molecule is a carbon atom; and R19is selected from a C1-C10 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R18and R19may together form a C1-C10 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety.

11. A compound as claimed in claim 10, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein the compound has the Formula (IIIa):Formula (IIIa) wherein: XA1is N, C-H or C-R10; XA2is N, C-H or C-R10; XA3is N, C-H or C-R10; and XA4is N, C-H or C-R10; provided that no more than three of XA1, XA2, XA3and XA4are N; and R1to R8, R10, R11, X12, R13, R18, R19, m, n and q are as defined in accordance with claim 10.

12. A compound as claimed in claim 10 or claim 11, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein R2is selected from hydrogen or a fluoro, chloro or bromo group.

13. A compound as claimed in any one of claims 10 to 12, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein R3is selected from hydrogen or a fluoro, chloro, bromo, -R30, -CN, -CHO, -COR30, -CO2H or -CO2R30group, wherein R30is selected from a C1-C6 alkyl, C1-C6 fluoroalkyl, C2-C6 alkenyl, C2-C6 fluoroalkenyl or -R31group, wherein R31is a 3- to 6-membered monocyclic group, wherein the 3- to 6-membered monocyclic group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and / or with one or two groups R32, wherein each R32is independently selected from a methyl or a fluoromethyl group,provided that the group R3, including any optional substituents, contains no more than 8 carbon atoms.

14. A compound of Formula (IV):Formula (IV) or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof; wherein: R1is hydrogen; R4is selected from hydrogen or a halo, -OH, -NH2, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R5is selected from hydrogen or a halo group; R6is selected from hydrogen or a halo, -R60or -OR60group, wherein R60is selected from a C1-C4alkyl, C3-C4cycloalkyl, C1-C4fluoroalkyl or C3-C4fluorocycloalkyl group; R7and R8are each independently selected from hydrogen or a fluoro or a C1-C12 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups,wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R7or R8that is directly attached to the reminder of the molecule is a carbon atom; or R7and R8together with the carbon atom to which they are attached form a 3- to 10-membered cyclic group, such that each ring atom of the cyclic group that is directly attached to the carbon atom to which R7and R8are attached is a ring carbon atom, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a halo, oxo (=O), -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; ring A is a phenyl or a 5- or 6-membered heteroaryl ring; p is 0, 1, 2, 3 or 4; each R10is independently selected from a halo, -OH, -NH2 or a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, and wherein the hydrocarbyl group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; or any two adjacent R10may together form a C1-C6saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbylene group may optionally be substituted with one or more groups R101, wherein each R101is independently selected from a halo group, and wherein the hydrocarbylene group may optionally include one, two or three heteroatoms each independently selected from N and O in its carbon skeleton; X12is NR121or C(R122)(R123); m is 0, 1 or 2, and n is 0, 1 or 2, provided that (i) m + n < 4, and (ii) when X12is NR121, m is 1 or 2 and n is 1 or 2; q is 0, 1, 2, 3, 4, 5, 6, 7 or 8;R11is selected from hydrogen or a fluoro or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom; R121is selected from hydrogen or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R121that is directly attached to the reminder of the molecule is a carbon atom; R122is selected from hydrogen or a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R123is selected from hydrogen or a fluoro or a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom ofany hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; each R13is independently selected from selected from a fluoro, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen, nitrogen or sulphur atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and R123, or R122and any R13, or R123and any R13, or any two R13may together form a C1-C8saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; each R14and R15is independently selected from hydrogen or a C1-C4alkyl, C3-C4cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group, or R14and R15together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally by substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; R16is selected from hydrogen or a fluoro, -SO2NH2, or a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S-moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R17is selected from hydrogen or a fluoro, C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4fluorocycloalkyl group; or R16and R17together with the carbon atom to which they are attached form a 3- to 6-membered cyclic group, wherein the cyclic group may optionally be substituted with one or more substituents each independently selected from a fluoro, -OH, oxo (=O), methyl or ethyl group, wherein any methyl or ethyl group may optionally be fluoro substituted; or R17and R7, or R4and R7, or R4and any R10, or R4and any R101, or R4and R11, or R4and R121, or R4and R122, or R4and R123, or R4and any R13, or R7and any R10, or R7and any R101, or R7and R11, or R7and R121, or R7and R122, or R7and R123, or R7and any R13, or any R10and R11, or any R10and R121, or any R10and R122, or any R10and R123, or any R10and any R13, or any R101and R11, or any R101and R121, or any R101and R122, or any R101and R123, or any R101and any R13, may together form a C1-C12 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight- chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; R18is selected from hydrogen or a C1-C10saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety, provided that the atom of any hydrocarbyl group of R18that is directly attached to the reminder of the molecule is a carbon atom; and R19is selected from a C1-C10 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or includeone or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted with one or more halo groups, wherein the hydrocarbyl group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety; or R18and R19may together form a C1-C10 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight-chained or branched, or be or include one or more cyclic groups, wherein the hydrocarbylene group may optionally be substituted with one or more halo groups, wherein the hydrocarbylene group may optionally include one or more heteroatoms each independently selected from N, O and S in its carbon skeleton, and wherein any -S- moiety may optionally be substituted with one or two groups each independently selected from oxo (=O) and =NH to form a -SO-, -SO2-, -S(=NH)- or -SO(=NH)- moiety.

15. A compound as claimed in claim 14, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein the compound has the Formula (IVa):wherein: XA1is N, C-H or C-R10; XA2is N, C-H or C-R10; XA3is N, C-H or C-R10; and XA4is N, C-H or C-R10;provided that no more than three of XA1, XA2, XA3and XA4are N; and R1, R4to R8, R10, R11, X12, R13to R19, m, n and q are as defined in accordance with claim 14.

16. A compound as claimed in claim 14 or claim 15, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein each R14and R15is independently selected from hydrogen or a C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group, or R14and R15together with the carbon atom to which they are attached form a cyclopropyl or a cyclobutyl group, wherein the cyclopropyl or cyclobutyl group may optionally be substituted with one or more fluoro groups.

17. A compound as claimed in any one of claims 14 to 16, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein: R16is selected from hydrogen or a fluoro, -R160, -CN, -CHO, -COR160, -CO2H or -CO2R160group, provided that R16, including any optional substituents, contains no more than 8 carbon atoms; R160is selected from a C1-C6alkyl, C1-C6fluoroalkyl, C2-C6alkenyl, C2-C6fluoroalkenyl or -R161group; R161is a 3- to 6-membered monocyclic group, wherein the 3- to 6-membered monocyclic group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and / or with one or two groups R162; each R162is independently selected from a methyl or a fluoromethyl group; and R17is selected from hydrogen or a fluoro, C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group; or R16and R17together with the carbon atom to which they are attached form a 3- to 5-membered saturated monocyclic group, wherein the saturated monocyclic group may optionally be substituted with one or more fluoro groups and / or one or two substituents each independently selected from oxo (=O) or a methyl or fluoromethyl group.

18. A compound as claimed in any one of claims 10 to 17, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein: R18is selected from hydrogen or a -R181or -COR181group, provided that where R18is -R181, the atom of the hydrocarbyl group of R181that is directly attached to the reminder of the molecule is a carbon atom;R181is a C1-C8saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbyl group may optionally include one, two, three or four heteroatoms each independently selected from N and O in its carbon skeleton; and R19is a C1-C8 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbyl group may optionally include one, two, three or four heteroatoms each independently selected from N and O in its carbon skeleton.

19. A compound as claimed in any one of claims 10 to 17, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein: R18and R19together form a group -L189-, wherein -L189- is a C2-C4 straight chained alkylene or alkenylene group, wherein the alkylene or alkenylene group may optionally include a nitrogen atom in its carbon skeleton, wherein the alkylene or alkenylene group has a chain length of 3 or 4 atoms, and wherein the alkylene or alkenylene group may optionally be substituted with one or more groups -R189, provided that -L189-, including any optional substituents, contains no more than 10 carbon atoms; each R189is independently selected from a fluoro, chloro, bromo, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, -R190or -SO2R190group, and / or any two R189attached to the same carbon atom may together form an oxo (=O) group, and / or any two R189attached to the same or different atoms may together with the atom or atoms to which they are attached form a 3- to 7-membered cyclic group, wherein the 3- to 7-membered cyclic group may optionally be substituted with one or more groups each independently selected from a fluoro, chloro, bromo, -OH, -NH2, -SH, -SO2H, -SO3H, -SO2NH2, -R190or -SO2R190group; and each R190is independently selected from a C1-C4 saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the hydrocarbyl group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and wherein the hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton.

20. A compound as claimed in any one of claims 1 to 19, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein: R4is selected from a fluoro, chloro, bromo, -OH, -OR41, -N(R42)2, -SO2-R41, -SO2-N(R42)2, -L4-OH, -L4-OR41, -L4-N(R42)2, -L4-SO2-R41, -L4-SO2-N(R42)2, -O-L4-OH, -O-L4-OR41, -O-L4-N(R42)2, -O-L4-SO2-R41, -O-L4-SO2-N(R42)2, -NR43-L4-OH, -NR43-L4-OR41, -NR43-L4-N(R42)2, -NR43-L4-SO2-R41, -NR43-L4-SO2-N(R42)2, -SO2-L4-OH, -SO2-L4-OR41, -SO2-L4-N(R42)2, -R44, -R45or -L4-R45group, provided that R4, including any optional substituents, contains no more than 8 carbon atoms; R41is selected from a -R44or -R45group; each R42is independently selected from hydrogen or a -R44or -R45group, or any two R42may, together with the nitrogen atom to which they are attached, form a 3- to 6-membered saturated monocyclic heterocyclic group, wherein the 3- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or two oxo (=O) groups and / or with one or more fluoro, methyl and / or fluoromethyl groups; L4is a straight-chained alkylene group, wherein the straight-chained alkylene group optionally includes one or two heteroatoms each independently selected from O and N in its carbon skeleton, wherein L4has a chain length of from 1 to 4 atoms, and wherein L4may optionally be substituted with one or two oxo (=O) groups and / or with one or more groups RL4; each RL4is independently selected from a fluoro, methyl or fluoromethyl group; or any RL4and R41, or any RL4and any R42, may together with the atoms to which they are attached, form a 3- to 6-membered saturated monocyclic heterocyclic group, wherein the 3- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or two oxo (=O) groups and / or with one or more fluoro, methyl and / or fluoromethyl groups; R43is selected from hydrogen or a -R44group; each R44is independently selected from a C1-C4alkyl or C3-C6cycloalkyl group, wherein the C1-C4alkyl or C3-C6cycloalkyl group may optionally be substituted with one or more fluoro groups and / or one or two oxo (=O) groups; and each R45is independently selected from a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more groups each independently selected from fluoro, chloro and bromo, and / or with one or two groups each independently selected from methyl (Me), -CN, -OH, -OMe, -NH2, -NHMe, and -NMe2, wherein any methyl group of R45may optionally be fluoro substituted.

21. A compound as claimed in any one of claims 1 to 20, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein R5is selected from hydrogen or a fluoro, chloro or bromo group.

22. A compound as claimed in any one of claims 1 to 21, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein: R6is selected from a chloro, bromo, -R60or -OR60group; and R60is selected from a C1-C3alkyl, cyclopropyl, C1-C3fluoroalkyl or fluorocyclopropyl group.

23. A compound as claimed in any one of claims 1 to 22, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein: R7is selected from hydrogen or a fluoro, -CN, -COOH, -COOR71, -CO-N(R72)2, -L7-COOH, -L7-COOR71, -L7-CO-N(R72)2, -L7-OH, -L7-OR71, -L7-N(R72)2, -R73, -R74or -L7-R74group, provided that R7, including any optional substituents, contains no more than 12 carbon atoms, and that the atom of R7that is directly attached to the reminder of the molecule is a carbon, hydrogen or fluorine atom; R71is selected from a -R73or -R74group; each R72is independently selected from hydrogen or a -R73or -R74group, or any two R72may, together with the nitrogen atom to which they are attached, form a 3- to 6- membered saturated monocyclic heterocyclic group, wherein the 3- to 6-membered saturated monocyclic heterocyclic group may optionally be substituted with one or two oxo (=O) groups and / or with one or more fluoro, methyl and / or fluoromethyl groups; L7is selected from a straight-chained alkylene or alkenylene group, wherein the straight-chained alkylene or alkenylene group optionally includes one or two heteroatoms each independently selected from O and N in its carbon skeleton, wherein L7has a chain length of from 1 to 4 atoms, and wherein L7may optionally be substituted with one or two oxo (=O) groups and / or with one or more groups RL7; each RL7is independently selected from a fluoro, methyl or fluoromethyl group; or any two RL7may, together with the atom or atoms to which they are attached, form a 3- to 6-membered monocyclic group, wherein the 3- to 6-membered monocyclic group is saturated or monounsaturated, and wherein the 3- to 6-membered monocyclic group may optionally be substituted with one or two oxo (=O) groups and / or with one or more fluoro, methyl and / or fluoromethyl groups;or any RL7and R71, or any RL7and any R72, may together with the atoms of the -L7-COOR71, -L7-CO-N(R72)2, -L7-OR71or -L7-N(R72)2 group to which they are attached, form a 3- to 6-membered monocyclic heterocyclic group, wherein the 3- to 6- membered monocyclic heterocyclic group is saturated or monounsaturated, and wherein the 3- to 6-membered monocyclic heterocyclic group may optionally be substituted with one or two oxo (=O) groups and / or with one or more fluoro, methyl and / or fluoromethyl groups; each R73is independently selected from a C1-C4 alkyl, C2-C4 alkenyl, C3-C6 cycloalkyl or C5-C6cycloalkenyl group, wherein the C1-C4alkyl, C2-C4alkenyl, C3-C6cycloalkyl or C5-C6 cycloalkenyl group may optionally be substituted with one or more fluoro groups and / or one or two oxo (=O) groups; and each R74is independently selected from a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more groups each independently selected from fluoro, chloro and bromo, and / or with one or two groups each independently selected from methyl (Me), -CN, -OH, -OMe, -NH2, -NHMe, and -NMe2, wherein any methyl group of R74may optionally be fluoro substituted; and R8is selected from a hydrogen or a fluoro, methyl or fluoromethyl group; or R7and R8together form a group -L78-, wherein -L78- is selected from a -CH2-CH2-, -CH2-CH2-CH2-, -CH2-NH-CH2-, -CH2-O-CH2-, -CH2-CH2-CH2-CH2-, -CH2-CH2-NH-CH2-, -CH2-CH2-O-CH2-, -CH2-NH-CH2-CH2- or -CH2-O-CH2-CH2- group, and wherein -L78- may optionally be substituted with one or more fluoro groups and / or one or two substituents each independently selected from an oxo (=O), -CN, methyl (Me), -OH, -OMe, -NH2, -NHMe or -NMe2group, wherein any methyl group of a -L78- substituent may optionally be fluoro substituted.

24. A compound as claimed in any one of claims 1 to 23, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein: one R10(if present) is selected from a fluoro, chloro, bromo, -OH, -NH2or a C1- C4 saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton, and each remaining R10(if present) is independently selected from a fluoro, chloro or bromo group;or two adjacent R10(if present) together form a C2-C4saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group is straight-chained, wherein the hydrocarbylene group may optionally be substituted with one or more fluoro, chloro and / or bromo groups, and / or with a single methyl, fluoromethyl, methoxy or fluoromethoxy group, and wherein the hydrocarbylene group may optionally include a single heteroatom selected from N and O in its carbon skeleton, such that the hydrocarbylene group has a chain length of 3 or 4 atoms, and each remaining R10(if present) is independently selected from a fluoro, chloro or bromo group.

25. A compound as claimed in any one of claims 1 to 24, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein R11is selected from hydrogen or a fluoro or a C1-C4saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O in its carbon skeleton, provided that the atom of any hydrocarbyl group of R11that is directly attached to the reminder of the molecule is a carbon atom.

26. A compound as claimed in any one of claims 1 to 25, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein X12is NR121, and m is 1 and n is 1.

27. A compound as claimed in claim 26, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein: R121is selected from hydrogen or a -R124, -R125or -L121-R125group, provided that any R121group, including any optional substituents, contains no more than 8 carbon atoms, and that any atom of -R124, -R125or -L121-R125that is directly attached to the reminder of the molecule is a carbon atom; R124is selected from a C1-C6saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton;R125is selected from a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more groups each independently selected from fluoro, chloro and bromo; and L121is a -CH2-, -C(=O)-, -CHMe- or -CMe2- group, wherein any -CH2-, -CHMe- or -CMe2- group may optionally be fluoro substituted.

28. A compound as claimed in any one of claims 1 to 25, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein X12is C(R122)(R123), and (i) m is 0 and n is 1, or (ii) m is 1 and n is 0, or (iii) m is 1 and n is 1.

29. A compound as claimed in claim 28, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein: R122is selected from hydrogen or a fluoro, -OH, -NH2, -R126, -SO2R126, -R127or -L122-R127group, provided that any R122group, including any optional substituents, contains no more than 8 carbon atoms; R126is selected from a C1-C6 saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, or be or include a cyclic group, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O), -CN or -SO2Me group, wherein the -SO2Me group may optionally be fluoro substituted, and wherein the saturated hydrocarbyl group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton; R127is selected from a phenyl or a 5- or 6-membered heteroaryl group, wherein the phenyl or the 5- or 6-membered heteroaryl group may optionally be substituted with one or more groups each independently selected from fluoro, chloro and bromo, and / or with a single methyl, fluoromethyl, -CN or -SO2Me group, wherein the -SO2Me group may optionally be fluoro substituted; L122is a -SO2-, -CH2-, -C(=O)-, -CHMe- or -CMe2- group, wherein any -CH2-, -CHMe- or -CMe2- group may optionally be fluoro substituted; and R123is selected from hydrogen or a fluoro or a C1-C4saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O inits carbon skeleton, provided that the atom of any hydrocarbyl group of R123that is directly attached to the reminder of the molecule is a carbon atom; or R122and R123together form a C2-C5 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group is straight-chained, wherein the hydrocarbylene group may optionally include one or two heteroatoms each independently selected from N, O and S in its carbon skeleton, wherein any -S- moiety may optionally be substituted with one or two oxo (=O) groups to form a -SO- or -SO2- moiety, wherein the hydrocarbylene group may optionally be substituted with one or more substitutents each independently selected from a fluoro, chloro, bromo, methyl (Me), ethyl (Et), -OH, -OMe, -OEt, -CH2OH, -CH2OMe, -CH2OEt, -NH2, -NHMe, -N(Me)2, -CH2NH2, -CH2NHMe, -CH2N(Me)2, oxo (=O), -CN, -CH2-, or -COMe group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of such a substituent may optionally be fluoro substituted, and wherein the hydrocarbylene group, including any optional substituents, contains no more than 6 carbon atoms.

30. A compound as claimed in any one of claims 1 to 29, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein q is 0, 1 or 2.

31. A compound as claimed in any one of claims 1 to 30, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein: each R13is independently selected from selected from a fluoro, -OH, -NH2, or a C1-C4 saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O in its carbon skeleton, provided that when R13is directly attached to a carbon atom which in turn is directly attached to an oxygen or nitrogen atom, the atom of R13that is directly attached to the remainder of the molecule is a fluorine or carbon atom; or any two R13attached to the same carbon atom together form a C2-C5 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group is straight- chained, wherein the hydrocarbylene group may optionally include one or two heteroatoms each independently selected from N, O and S in its carbon skeleton, wherein any -S- moiety may optionally be substituted with one or two oxo (=O) groups to form a -SO- or -SO2- moiety, wherein the hydrocarbylene group may optionally be substituted with one or more substitutents each independently selected from a fluoro,chloro, bromo, methyl (Me), ethyl (Et), -OH, -OMe, -OEt, -CH2OH, -CH2OMe, -CH2OEt, -NH2, -NHMe, -N(Me)2, -CH2NH2, -CH2NHMe, -CH2N(Me)2, oxo (=O), -CN, -CH2-, or -COMe group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of such a substituent may optionally be fluoro substituted, and wherein the hydrocarbylene group, including any optional substituents, contains no more than 6 carbon atoms.

32. A compound as claimed in any one of claims 1 to 31, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein: R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and any R13, or R123and any R13, or any two R13, when attached to adjacent ring atoms, together form a C1-C4saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group is straight-chained, wherein the hydrocarbylene group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton, wherein the hydrocarbylene group may optionally be substituted with one or more substitutents each independently selected from a fluoro, chloro, bromo, methyl (Me), ethyl (Et), -OH, -OMe, -OEt, -CH2OH, -CH2OMe, -CH2OEt, -NH2, -NHMe, -N(Me)2, -CH2NH2, -CH2NHMe, -CH2N(Me)2, oxo (=O), -CN, -CH2-, or -COMe group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of such a substituent may optionally be fluoro substituted, and wherein the hydrocarbylene group, including any optional substituents, contains no more than 6 carbon atoms; or R11and R121, or R11and R122, or R11and R123, or R11and any R13, or R121and any R13, or R122and any R13, or R123and any R13, or any two R13, when attached to non- adjacent ring atoms, together form a C1-C4 saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group is straight-chained, wherein the hydrocarbylene group may optionally include one or two heteroatoms each independently selected from N and O in its carbon skeleton, wherein the hydrocarbylene group may optionally be substituted with one or more substitutents each independently selected from a fluoro, chloro, bromo, methyl (Me), ethyl (Et), -OH, -OMe, -OEt, -CH2OH, -CH2OMe, -CH2OEt, -NH2, -NHMe, -N(Me)2, -CH2NH2, -CH2NHMe, -CH2N(Me)2, oxo (=O), -CN, -CH2-, or -COMe group, wherein any methyl (Me), ethyl (Et) or methylene (-CH2-) group of such a substituent may optionally be fluoro substituted, and wherein the hydrocarbylene group, including any optional substituents, contains no more than 6 carbon atoms;provided that no more than one of (i) R11and R121, or (ii) R11and R122, or (iii) R11and R123, or (iv) R11and any single R13, or (v) R121and any single R13, or (vi) R122and R123, or (vii) R122and any single R13, or (viii) R123and any single R13, or (ix) any two R13, together form a hydrocarbylene group.

33. A compound as claimed in claim 1, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein the compound has the Formula (Id) or (Ie):wherein: R3is selected from hydrogen or a fluoro, chloro or bromo group; R4is selected from a fluoro, chloro, bromo, -R44or -OR44group; R44is selected from a C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group; R6is a methyl or a fluoromethyl group; R7and R8are each independently selected from hydrogen or a fluoro, methyl or fluoromethyl group; R9is a phenyl or a 6-membered heteroaryl group, wherein the phenyl or the 6- membered heteroaryl group is (i) substituted with at least one fluoro group, and / or (ii) substituted with one or two substituents each independently selected from a fluoromethyl, fluoroethyl or -R91group, provided that where the phenyl or the 6- membered heteroaryl group of R9is substituted with one or two -R91groups, each R91group is attached to the phenyl or the 6-membered heteroaryl ring at the 2-, 4- or 6-position, relative to the point of attachment of the phenyl or the 6-membered heteroaryl ring to the remainder of the molecule; each R91group is independently selected from a -NO2, -SO3H, -OR92, -CHO, -COR92, -COOH, -COOR92, -CONH2, -CONHR92, -CON(R92)2, -SO2R92, -SO2NH2, -SO2NHR92or -SO2N(R92)2group; each R92is independently selected from a methyl, ethyl, fluoromethyl or fluoroethyl group; XA1is N, C-H or C-R10; XA2is N, C-H or C-R10; XA3is N, C-H or C-R10; and XA4is N, C-H or C-R10; provided that no more than two of XA1, XA2, XA3and XA4are N, and that no more than two of XA1, XA2, XA3and XA4are C-R10; one R10(if present) is selected from a fluoro, methyl or fluoromethyl group, and the remaining R10(if present) is a fluoro group; R121is selected from a C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group; R122is selected from hydrogen or a fluoro, -R128or -OR128group; and R128is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group.

34. A compound as claimed in claim 10, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein the compound has the Formula (IIId) or (IIIe):wherein: R3is selected from hydrogen or a fluoro, chloro or bromo group; R4is selected from a fluoro, chloro, bromo, -R44or -OR44group; R44is selected from a C1-C3alkyl, cyclopropyl, C1-C3fluoroalkyl or fluorocyclopropyl group; R6is a methyl or a fluoromethyl group; R7and R8are each independently selected from hydrogen or a fluoro, methyl or fluoromethyl group;XA1is N, C-H or C-R10; XA2is N, C-H or C-R10; XA3is N, C-H or C-R10; and XA4is N, C-H or C-R10; provided that no more than two of XA1, XA2, XA3and XA4are N, and that no more than two of XA1, XA2, XA3and XA4are C-R10; one R10(if present) is selected from a fluoro, methyl or fluoromethyl group, and the remaining R10(if present) is a fluoro group; each XVis independently selected from N, C-H, C-Hal or C-R183, provided that no more than one XVis N, and no more than two XVare C-R183, and provided that the group, including any optional substituents, contains no more than 10 carbon atoms; each Hal is independently selected from a fluoro, chloro or bromo group; each R183is independently selected from a -OH, -NH2or -R193group, or any two R183attached to adjacent carbon atoms may, together with atoms to which they are attached, form a 5- or 6-membered fused cyclic group, wherein the 5- or 6-membered fused cyclic group may optionally be substituted with one or more fluoro, chloro and / or bromo groups and / or with a single -OH, -NH2or -R193group; each R193is independently selected from a C1-C3 saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O in its carbon skeleton; R121is selected from a C1-C3alkyl, cyclopropyl, C1-C3fluoroalkyl or fluorocyclopropyl group; R122is selected from hydrogen or a fluoro, -R128or -OR128group; and R128is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group.

35. A compound as claimed in claim 10, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein the compound has the Formula (IIIf) or (IIIg):wherein: R3is selected from hydrogen or a fluoro, chloro or bromo group; R4is selected from a fluoro, chloro, bromo, -R44or -OR44group; R44is selected from a C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group;R6is a methyl or a fluoromethyl group; R7and R8are each independently selected from hydrogen or a fluoro, methyl or fluoromethyl group; XA1is N, C-H or C-R10; XA2is N, C-H or C-R10; XA3is N, C-H or C-R10; and XA4is N, C-H or C-R10; provided that no more than two of XA1, XA2, XA3and XA4are N, and that no more than two of XA1, XA2, XA3and XA4are C-R10; one R10(if present) is selected from a fluoro, methyl or fluoromethyl group, and the remaining R10(if present) is a fluoro group; is a single or double bond; t is 0, 1 or 2; each R185is independently selected from a fluoro, -SO3H, -R196, -OR196or -SO2R196group, provided that no more than one -SO3H, -OR196or -SO2R196group is present, or two R185attached to adjacent carbon atoms, together with carbon atoms to which they are attached, form a 5- to 7-membered fused cyclic group, wherein the 5- to 7-membered fused cyclic group may optionally be substituted with one or more fluoro groups and / or with one or two substituents each independently selected from a -SO3H, -R196, -OR196or -SO2R196group, provided that no more than one -SO3H, -OR196or -SO2R196group is present; each R196is independently selected from a C1-C3 alkyl, cyclopropyl, C1-C4 fluoroalkyl or fluorocyclopropyl group; the group, including any optional substituents, contains no more than 10 carbon atoms; R121is selected from a C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group; R122is selected from hydrogen or a fluoro, -R128or -OR128group; and R128is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group.

36. A compound as claimed in claim 10, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein the compound has the Formula (IIIh) or (IIIi):Formula (IIIi) wherein: R3is selected from hydrogen or a fluoro, chloro or bromo group; R4is selected from a fluoro, chloro, bromo, -R44or -OR44group; R44is selected from a C1-C3alkyl, cyclopropyl, C1-C3fluoroalkyl or fluorocyclopropyl group; R6is a methyl or a fluoromethyl group;R7and R8are each independently selected from hydrogen or a fluoro, methyl or fluoromethyl group; R19is a phenyl or a 6-membered heteroaryl group, wherein the phenyl or the 6- membered heteroaryl group may optionally be substituted with one or more substituents each independently selected from fluoro, chloro and bromo, and / or with one or two substituents each independently selected from a -OH, -NH2, -NO2, -SH, -SO2H, -SO3H, -SO2NH2, -R191or -SO2R191group, provided that R19, including any optional substituents, contains no more than 10 carbon atoms; each R191is independently selected from a C1-C3saturated hydrocarbyl group, wherein the saturated hydrocarbyl group may be straight-chained or branched, wherein the saturated hydrocarbyl group may optionally be substituted with one or more fluoro groups and / or a single oxo (=O) group, and wherein the saturated hydrocarbyl group may optionally include a single heteroatom selected from N and O in its carbon skeleton; XA1is N, C-H or C-R10; XA2is N, C-H or C-R10; XA3is N, C-H or C-R10; and XA4is N, C-H or C-R10; provided that no more than two of XA1, XA2, XA3and XA4are N, and that no more than two of XA1, XA2, XA3and XA4are C-R10; one R10(if present) is selected from a fluoro, methyl or fluoromethyl group, and the remaining R10(if present) is a fluoro group; R121is selected from a C1-C3 alkyl, cyclopropyl, C1-C3 fluoroalkyl or fluorocyclopropyl group; R122is selected from hydrogen or a fluoro, -R128or -OR128group; and R128is selected from a C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 fluoroalkyl or C3-C4 fluorocycloalkyl group.

37. A compound, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, wherein the compound is an active ester of a Factor B inhibitor, wherein the Factor B inhibitor comprises a carboxylic acid (-COOH) group.

38. A compound selected from the group consisting of:or a pharmaceutically acceptable salt and / or solvate and / or prodrug of the selected compound.

39. A pharmaceutical composition comprising a compound, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, as claimed in any one of claims 1 to 38, and a pharmaceutically acceptable excipient.

40. A compound, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, as claimed in any one of claims 1 to 38, or a pharmaceutical composition as claimed in claim 39, for use in medicine.

41. A compound, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, as claimed in any one of claims 1 to 38, or a pharmaceutical composition as claimed in claim 39, for use in the treatment or prevention of a disease, disorder or condition, wherein the disease, disorder or condition is responsive to Factor B inhibition.

42. A compound, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, or a pharmaceutical composition, as claimed in claim 40 or claim 41,for use in the treatment or prevention of a disease, disorder or condition, wherein the disease, disorder or condition is selected from: (i) an ocular disease, disorder or condition; (ii) a haematological disease, disorder or condition; (iii) a renal disease, disorder or condition; (iv) a respiratory disease, disorder or condition; (v) a central nervous system disease, disorder or condition; (vi) a cardiovascular disease, disorder or condition; (vii) a reproductive disease, disorder or condition; (viii) a metabolic disease, disorder or condition; (ix) a cancer; (x) an auto-immune disease, disorder or condition; (xi) a musculoskeletal disease, disorder or condition; (xii) antiphospholipid syndrome; (xiii) a skin disease, disorder or condition; (xiv) hemodialysis; or (xv) any disease where an individual has been determined to carry a germline or somatic non-silent mutation in Factor B.

43. A compound, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, or a pharmaceutical composition, as claimed in claim 40 or claim 41, for use in the treatment or prevention of a disease, disorder or condition, wherein the disease, disorder or condition is selected from: (i) acute kidney injury; (ii) age-related macular degeneration; (iii) airway hyperresponsiveness with inflammation; (iv) Alzheimer’s disease; (v) amyotrophic lateral sclerosis; (vi) ANCA vasculitis; (vii) antiphospholipid syndrome; (viii) aortic stenosis; (ix) atypical hemolytic uremic syndrome; (x) acquired thrombotic thrombocytopenic purpura; (xi) bullous pemphigoid; (xii) C3 glomerulopathy;(xiii) immune complex-mediated membranoproliferative glomerulonephritis (IC- MPGN) (xiv) cardiac ischemia and reperfusion; (xv) cardiac remodelling; (xvi) cardiometabolic disease; (xvii) coeliac disease; (xviii) cold agglutinin disease; (xix) a respiratory condition caused by SARs Cov-2; (xx) a delayed hemolytic transfusion reaction (DHTR) in an individual suffering from sickle cell disease; (xxi) diabetic kidney disease; (xxii) diabetic retinopathy; (xxiii) Doyne honeycomb retinal dystrophy, also known as malattia leventinese (DHRD / ML); (xxiv) focal segmental glomerulosclerosis (FSGS); (xxv) glomerular sclerosis; (xxvi) Guillian-Barré syndrome; (xxvii) heart failure; (xxviii) hemodialysis; (xxix) idiopathic thrombocytopenic purpura (ITP); (xxx) idiopathic pulmonary fibrosis; (xxxi) IgA nephropathy; (xxxii) ischemic stroke; (xxxiii) systemic lupus erythematosus; (xxxiv) lupus nephritis (xxxv) lupus cerebritis; (xxxvi) malignant nephrosclerosis; (xxxvii) multiple sclerosis; (xxxviii) myasthenia gravis; (xxxix) neuromyelitis optica; (xl) non-infectious uveitis; (xli) osteoarthritis; (xlii) pancreatic cancer; (xliii) paroxysmal nocturnal hemoglobinuria (PNH); (xliv) photocarcinogenesis; (xlv) postinfectious glomerulonephritis;(xlvi) pre-eclampsia; (xlvii) membranous nephropathy; (xlviii) renal allograft; (xlix) retinal detachment; (l) retinal ischemia reperfusion; (li) rheumatoid arthritis; (lii) schizophrenia; (liii) spinal cord injury; (liv) squamous cell carcinoma; (lv) thrombotic microangiopathy (TMA)-mediated acute kidney injury (AKI); (lvi) transplant-associated thrombotic microangiopathy; or (lvii) traumatic brain injury.

44. A method of inhibiting Factor B, the method comprising the use of a compound, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, as claimed in any one of claims 1 to 38, or a pharmaceutical composition as claimed in claim 39, to inhibit Factor B.

45. A method of synthesising a compound, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, as claimed in claim 1, the method comprising the step of: (i) reacting a compound of Formula (SM-1) with a compound of Formula R9OH to produce a compound of Formula (I), or a pharmaceutically acceptable salt and / or solvate thereof:wherein ring A, R1to R11, X12, R13, m, n, p and q are as defined in accordance with claim 1.

46. A method of synthesising a compound, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, as claimed in claim 5, the method comprising the step of: (i) reacting a compound of Formula (SM-2) with a compound of Formula R9OH to produce a compound of Formula (II), or a pharmaceutically acceptable salt and / or solvate thereof:Formula (SM-2) Formula (II) wherein ring A, R1, R4to R11, X12, R13to R17, m, n, p and q are as defined in accordance with claim 5.

47. A method of synthesising a compound, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, as claimed in claim 10, the method comprising the step of: (i) reacting a compound of Formula (SM-1) with a compound of Formula R19CON(R18)OH to produce a compound of Formula (III), or a pharmaceutically acceptable salt and / or solvate thereof:Formula (SM-1) Formula (III) wherein ring A, R1to R8, R10, R11, X12, R13, R18, R19, m, n, p and q are as defined in accordance with claim 10.

48. A method of synthesising a compound, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, as claimed in claim 14, the method comprising the step of: (i) reacting a compound of Formula (SM-2) with a compound of Formula R19CON(R18)OH to produce a compound of Formula (IV), or a pharmaceutically acceptable salt and / or solvate thereof:wherein ring A, R1, R4to R8, R10, R11, X12, R13to R19, m, n, p and q are as defined in accordance with claim 14.

49. A method of synthesising a compound, or a pharmaceutically acceptable salt and / or solvate and / or prodrug thereof, as claimed in claim 37, the method comprising the step of reacting a Factor B inhibitor comprising a carboxylic acid group with an alcohol to form an active ester.

Images