Hair growth promotion composition including eggshell membrane and bean sprout extract

Abstract

[Problem] To provide a safe hair growth promotion composition for oral administration that has high hair growth promotion effects and can be used as a food, beverage, or supplement. [Solution] This hair growth promotion composition contains eggshell membrane and bean sprout extract, is highly safe for the human body and skin, and achieves synergistic function between the eggshell membrane and bean sprout extract to give hair resilience and body and increase gloss and achieve excellent hair growth promotion effects that promote the growth of hair to increase the number of healthy hairs.

Description

Hair growth promoting composition containing eggshell membrane component and pea seedling extract

[0001] The present invention relates to a composition for promoting hair growth, which promotes hair growth and hair regeneration and prevents hair loss.

[0002] The quality and quantity of hair vary from person to person, and some people are born with or have had thin hair from a young age due to a small number of hairs, thin hair, or other factors. Also, as people age, their hair may thin or fall out more easily, leading to hair thinning. Furthermore, medical factors such as stress and side effects from medications can cause hair loss, thinning, or reduced hair growth, all or part of the scalp.

[0003] To solve this problem, various hair growth and hair loss promoters have been developed, such as hair growth agents containing peptides as active ingredients that promote hair growth and inhibit hair loss (Patent Documents 1 and 2), and those containing various plant extracts that promote blood circulation and suppress immunosuppression as active ingredients. However, only a few of these products are consistently effective, and some may cause symptoms such as redness, itchiness, and rashes.

[0004] Eggshell membrane is the membrane found inside the eggshell of avian eggs such as chicken eggs. It consists of two layers, an inner and an outer layer. The outer shell membrane adheres to the inner surface of the eggshell, while the inner shell membrane encases the egg white. It has antibacterial properties and protects the developing embryo from infection. Eggshell membrane has a mesh-like structure composed of tough fibrous proteins, mainly composed of type I, type V, and type X collagen, glucosamine, desmosine, and hyaluronic acid. Many of these proteins contain cystine, and are relatively stable against acids, alkalis, and proteases, and are insoluble in water. It is known to promote skin regeneration and has been put to practical use in cosmetics and nutritional supplements.

[0005] In order to solubilize insoluble eggshell membranes in water and increase the digestion and absorption efficiency of eggshell membrane components, eggshell membrane proteins are hydrolyzed in an acid or alkaline aqueous solution or with a protease (Patent Document 3), to produce soluble hydrolyzed eggshell membrane components, which are used as raw materials for supplements and cosmetics. Patent Document 4 also describes that the hair growth promoting effect of eggshell membrane components is particularly high when hydrolyzed by enzymatic hydrolysis.

[0006] Furthermore, egg white, which is enclosed in the eggshell membrane, is an ideal food with low fat and high protein nutritional value, and the egg white protein contained therein is an excellent protein with higher nutritional value than other plant or animal proteins. After laying, eggs are incubated for 21 days until a chick hatches from the egg, during which time no nutritional supplementation is provided. Since chicks are born with 100% feathers from the moment they are born, chicken eggs contain all the components necessary for hair growth, and it has been reported that egg white, a high-quality protein that is the raw material for hair, and eggshell membrane, which is rich in cystine, have the function of promoting hair growth (Patent Document 5).

[0007] Japanese Patent Publication No. 2009-57328 Japanese Patent No. 6393772 Japanese Patent Publication No. 7-110210 Japanese Patent Publication No. 2019-137619 Japanese Patent Publication No. 2022-134216

[0008] The present invention aims to provide a hair growth promoting composition that has a high hair growth promoting effect, is safe, and can be used as a food, drink, or supplement.The present invention aims to provide an oral hair growth promoting composition that exerts excellent hair growth and hair growth promoting effects, imparting firmness and body to hair, increasing its luster, and promoting the growth of the hair itself to increase the number of healthy hairs.

[0009] Chicken eggs contain all the components necessary for chick hair growth, and as a result of intensive research into components that can further enhance the hair growth promoting function of egg white, a high-quality protein that is the raw material for hair, and eggshell membrane, which is rich in cystine, we discovered that an extract of pea sprouts, a type of germinated vegetable, can significantly enhance the hair growth effect of these egg-derived components, leading to the completion of this invention.

[0010] The present invention relates to hair growth-promoting compositions as set forth in (1) to (5) below. (1) A hair growth-promoting composition comprising an eggshell membrane component and a pea sprout extract. (2) The hair growth-promoting composition according to (1) above, wherein the eggshell membrane component comprises a hydrolyzed eggshell membrane component and the pea sprout extract is pea sprout extract powder. (3) The hair growth-promoting composition according to (1) above, comprising an egg white component that is egg white powder and / or egg white peptide. (4) The hair growth-promoting composition according to (3) above, further comprising egg yolk oil and / or eggshell calcium. (5) The hair growth-promoting composition according to any one of (1) to (4) above, which is for oral administration. The present invention also relates to foods, beverages, or supplements as set forth in (6) and (7) below. (6) A food, beverage, or supplement comprising the hair growth-promoting composition according to (5) above. (7) The food, beverage, or supplement according to (6) above, which is in the form of granules, tablets, capsules, liquid, or a drink.

[0011] Alternatively, the present invention relates to hair growth-promoting compositions as set forth in (1) to (5) below. (1) A hair growth-promoting composition comprising an eggshell membrane component and a pea sprout extract. (2) The hair growth-promoting composition according to (1) above, wherein the eggshell membrane component comprises a hydrolyzed eggshell membrane component, and the pea sprout extract is pea sprout extract powder. (3) The hair growth-promoting composition according to (1) or (2) above, comprising an egg white component that is egg white powder and / or an egg white peptide. (4) The hair growth-promoting composition according to any one of (1) to (3) above, further comprising egg yolk oil and / or eggshell calcium. (5) The hair growth-promoting composition according to any one of (1) to (4) above, which is for oral administration. The present invention also relates to foods, beverages, or supplements as set forth in (6) and (7) below. (6) A food, beverage, or supplement comprising the hair growth-promoting composition according to any one of (1) to (5) above. (7) The food, drink or supplement described in (6) above, which is in the form of granules, tablets, capsules, liquid, or a drink.

[0012] Among eggshell membrane components, some hydrolyzed eggshell membrane components have a cystine content that is 20 times higher than that of eggshell membrane components. By combining these hydrolyzed eggshell membrane components with egg white components containing the sulfur-containing amino acids cystine and egg white proteins with high cysteine ​​content, the cystine content necessary for hair can be further increased. Furthermore, by combining egg yolk components such as egg yolk oil and eggshell calcium, all of the components and energy sources of chicken eggs can be utilized. In the present invention, by combining these egg-derived components with an extract of pea sprouts, a type of germinated vegetable (sprout) known for its hair growth and growth effects, the hair growth promotion effect is significantly improved through a synergistic effect, and a hair growth effect that can be felt by the user is obtained.

[0013] The composition of the present invention can be taken as an oral composition that can be easily taken daily, as a food, drink, or supplement in the form of granules, tablets, capsules, liquids, or drinks. Furthermore, because it uses egg-derived ingredients and pea sprout extract, which are naturally derived and highly safe for the human body, there is no adverse effect on health even when they are incorporated in large amounts during the production of food, drink, or supplements. Because it is non-irritating and can be used in combination with various hair growth and hair restoration ingredients in various forms, it not only exhibits a higher hair growth effect, but also exhibits the inherent effects of egg-derived ingredients in promoting beautiful skin and health.

[0014] The hair growth promoting composition of the present invention is characterized by containing an eggshell membrane component and a pea sprout extract. In this specification, the terms "hair growth" and "hair growth promotion" refer to a hair-growing effect that results in an increase in the amount of hair (number, thickness, etc.), an effect that increases the rate of hair growth, or an effect that improves hair health, such as one or more effects such as promoting hair growth or hair regeneration, or reducing or preventing hair loss. The hair growth promotion of the present invention includes effects such as promoting hair regeneration, hair care, and preventing hair loss.

[0015] The eggshell membrane can be any membrane found inside the eggshell of any egg of a terrestrial oviparous animal, particularly an avian egg, and chicken eggshell membrane is particularly preferred from the standpoint of availability and cost. The eggshell membrane component of the present invention is preferably in the form of a powder containing at least eggshell membrane, and for example, eggshell membrane powder obtained by powdering an eggshell membrane-containing raw material such as peeled eggshell membrane with a known blender, mixer, mill or grinder, or a commercially available eggshell membrane-containing powder can be used.

[0016] The hydrolyzed eggshell membrane component is a soluble eggshell membrane component obtained by hydrolyzing eggshell membrane or eggshell membrane-containing powder in a liquid with a protein-degrading action, such as an acid aqueous solution, an alkaline aqueous solution, an alkaline organic solvent solution, or a protease-containing solution. The hydrolyzed eggshell membrane component used in the present invention may be a hydrolyzed eggshell membrane component produced by any method, but those produced by alkaline hydrolysis and / or enzymatic hydrolysis are preferred. While it can be used as an aqueous solution or extract, powder forms obtained by drying methods such as spray drying and freeze drying are preferred for ease of handling and storage stability.

[0017] The egg white component of the present invention can be liquid egg white, powdered egg white, egg white protein, or egg white peptide, with low-molecular-weight egg white peptide being preferred. Egg white protein contained in egg white is low-fat and high in protein, with a high content of sulfur-containing amino acids such as cystine, cysteine, and methionine, as well as branched-chain amino acids. Furthermore, compared to other animal proteins such as milk protein and plant proteins such as soy protein, egg white peptides are easily digested, absorbed, and utilized in the body, resulting in high nutritional value. Egg white peptides are produced by enzymatically depolymerizing egg white protein, and while maintaining the amino acid balance of egg white protein, they are digested and absorbed more quickly than egg white protein. Those with an average molecular weight of 200 to 1,500, particularly 600 to 1,000, which have a reduced sulfur odor characteristic of egg white, are preferred.

[0018] Egg yolk oil is a lower alcohol extract of egg yolk obtained by extracting lipids such as lecithin and other oily components from egg yolk using a lower alcohol such as ethanol. It contains egg yolk lecithin and other oily components derived from egg yolk, making it rich and highly nutritious. The lower alcohol extract may be used as is, or, if necessary, the extract may be dried and solidified. Commercially available products may also be used. Eggshell calcium is a fine powder obtained by crushing and drying the shells of avian eggs, such as chicken eggs. Its porous structure allows the calcium component to be easily absorbed by the body. When incorporated into tablets, it prevents the alteration and decomposition of the ingredients contained therein and improves the scratch resistance of the tablet surface.

[0019] In addition to eggshell membrane ingredients, when egg white ingredients containing the sulfur-containing amino acid cystine and egg white protein with a high cysteine ​​content are used in combination, the cystine content necessary for hair is further increased. Furthermore, when egg yolk oil and eggshell calcium are used in combination, the power of eggs, which are full of vitality and contain all the components and energy sources of chicken eggs, can be utilized.

[0020] The bean sprouts used as the raw material for the bean sprout extract of the present invention are sprouted vegetables (sprouts) of the legume pea, commonly known as bean sprouts, which are obtained by artificially germinating pea seeds in the dark and allowing them to grow elongated. Sprouts are generally said to have concentrated vitality for growth. The bean sprout extract is a water-soluble extract from bean sprouts, and can be obtained, for example, by cutting raw bean sprouts, adding water, and heating at 100°C under normal pressure for about 30 minutes, or by powdering.

[0021] As the pea sprout extract powder used in the present invention, Anagain (H. Holstein Co., Ltd.), which uses sprouts germinated from organic peas, has been proven to promote hair growth and development at an effective dose of 100 mg / day through oral and transdermal clinical trials, and is therefore preferably used.

[0022] In the hair growth-promoting composition of the present invention, the respective contents of the eggshell membrane component and pea sprout extract powder are not particularly limited. Since the effective amount of pea sprout extract powder is 100 mg / day, the content is set to allow intake of that effective amount depending on the form of use of the hair growth-promoting composition of the present invention, and the eggshell membrane component is preferably contained in an amount of 1 to 50% by weight, calculated on a dry matter basis. Furthermore, the weight ratios of the egg white component, egg yolk oil, and eggshell calcium are not particularly limited, but since egg yolk oil is an oil and fat component, it is preferably about 1 / 5 or less of the other components. The hair growth-promoting composition of the present invention may also contain other hair growth active ingredients and various ingredients for improving storage stability, dispersibility, etc., as necessary.

[0023] The hair growth-promoting composition of the present invention can be prepared as an oral composition such as a tablet, powder, granule, capsule, liquid, or drink. Because it is non-irritating, there are no particular limitations on the dosage form, and the various ingredients and manufacturing methods for producing oral compositions in various dosage forms can be appropriately selected from ingredients known in the fields of supplement and pharmaceutical manufacturing. Tablets are preferred because they are suitable for storage and distribution, do not deform or disintegrate upon administration, and can be easily taken orally.

[0024] The granules, capsules, or tablets of this embodiment can be supplemented with various known additives for forming granules, capsules, or tablets, including excipients, binders, disintegrants, lubricants, other nutrients, and the like. Any known excipient can be used as the excipient, but from the standpoint of formability, at least one of modified starch and lactose is preferably used in an amount 0.3 to 3 times, and more preferably 1 to 2.5 times, the weight of the eggshell membrane component. As the modified starch, one or more of dextrins such as roasted dextrin, oxidized starch, low-viscosity modified starch, and the like can be used.

[0025] As the binder, any known binder can be used as appropriate, including starch paste, gum arabic paste, hydroxypropyl cellulose, etc. As the disintegrant, any known disintegrant can be used as appropriate, including celluloses such as crystalline cellulose, etc. As the lubricant, any known lubricant can be used as appropriate, including magnesium stearate, calcium stearate, sucrose fatty acid esters, waxes, talc, vitamin C, etc.

[0026] The tablets may also contain eggshell calcium as a hardness enhancer to increase tablet hardness, prevent deformation and damage, and improve handleability. Eggshell calcium is a fine powder made by crushing and drying the shells of avian eggs, such as chicken eggs. Furthermore, to prevent deterioration and decomposition of the ingredients contained in the tablet and improve the scratch resistance of the tablet surface, it is preferable to cover the tablet with a coating film. The size of the tablet in this embodiment is not particularly limited, but a round or oval shape with a diameter of approximately 7 to 10 mm is generally preferred for ease of handling and administration. Each tablet weighs approximately 350 to 600 mg, and preferably contains 10 to 240 mg, more preferably 20 to 150 mg, of the active ingredient.

[0027] The oral liquid preparations (such as solutions, suspensions, emulsions, syrups, and elixirs) and drinks of the present invention are produced by dissolving, suspending, or emulsifying the active ingredient in a commonly used diluent (such as purified water, ethanol, or a mixture thereof). These liquid preparations may further contain emulsifiers, suspending agents, wetting agents, sweeteners, flavoring agents, preservatives, etc.

[0028] The hair growth promoting composition of the present invention can contain other hair growth active ingredients. For example, preferred are keratin hydrolysate, which is a main component of hair, silk hydrolysate, cystine sources such as L-cystine, Gagnai powder, and zinc-containing yeast. Furthermore, any vitamin can be used, and vitamin B2, which helps maintain healthy skin and mucous membranes, is particularly effective.

[0029] Furthermore, the oral composition of the present invention can be used as a food additive for confectionery, beverages, health foods, preserved foods, processed foods, etc. Here, the subject of "foods and beverages" and "supplements" is not limited to humans, but also includes feed for mammals such as pets and livestock. Furthermore, the concepts of "foods and beverages" and "supplements" include not only ordinary foods and beverages, but also enteral nutritional foods, functional foods, foods with functional claims, foods for specified health uses, etc.

[0030] The present invention will be described in detail below based on examples, but the present invention is not limited to these examples.

[0031] Example 1: Tablet Production 40 parts by weight of hydrolyzed eggshell membrane-containing powder (trade name: "ESM Protein"; Almado Co., Ltd.) and 40 parts by weight of pea sprout extract powder (trade name: "Anagain"; registered trademark, manufactured by H. Holstein Co., Ltd.) were mixed with 40 parts by weight of egg white peptide (trade name: "Egg White Peptide EP-1"; Kewpie Corporation) 3 parts by weight of egg yolk oil (trade name: "Egg Yolk Lecithin PL-30S"; Kewpie Corporation) 10 parts by weight of eggshell calcium (trade name: "Calhope"; Kewpie Corporation). Further, keratin hydrolyzate, silk hydrolyzate, L-cystine, Gagnai powder, zinc-containing yeast, and vitamin B2 were added and mixed using a V-type mixer to prepare a raw material mixture. 93 parts by weight of this raw material mixture was mixed with 15 parts by weight of ethyl alcohol, and the resulting mixture was granulated using a wet granulator and then dried at 50°C for approximately 16 hours to produce granules for tableting.

[0032] 100 parts by weight of granules for tableting were mixed with 9 parts by weight of vitamin C and 1 part by weight of sucrose fatty acid ester, and the resulting mixture was used in a tableting machine to produce plain tablets each weighing 350 mg. An aqueous solution of the product name "Shellac" (Gifu Shellac Co., Ltd.) was applied to the surface of the plain tablets using a coating device and dried at 40°C for 2 hours to obtain protectively coated tablets. The polished tablets were sorted to remove defective products, weighed after product inspection, and packaged in double bags containing a desiccant. The tablets had sufficient hardness and shape retention, did not deform or disintegrate during sorting, inspection, or packaging, and were easy to handle. Each tablet weighed 400 mg and contained 50 mg of eggshell membrane components and 50 mg of pea sprout extract powder.

[0033] [Example 2] Oral test Twenty-four women aged between 45 and 65 years old were subjects who noticed that their scalp hair had become thinner than before, that their hair had lost elasticity and strength, and that their overall hair volume had decreased. For four months after the start of the test, they continuously took two tablets of the tablet prepared in Example 1 per day.

[0034] Regarding the condition of their hair four months after starting the medication, the subjects were asked to select multiple answers from (1) to (5) regarding the improvements they felt: (1) less hair loss, (2) more firmness, strength, and shine to their hair, (3) more hair overall and more volume, (4) their part is no longer a concern, and (5) other (hair looks cleaner, etc.). The results are shown in Table 1.

[0035]

[0036] In addition, when respondents were asked to voluntarily write their personal impressions in the questionnaire, many wrote comments such as, "The amount of hair that falls out after shampooing is really small. I thought it was just a coincidence, but it's less every day. It's more effective than any of the hair care supplements I've taken up until now.", "I think my hair is healthier. It stands up better and is shinier.", "I've been losing less hair when shampooing recently, which is great for not only my hair but also my skin," and "My hair has become stronger and more resilient, which has given it more volume."

[0037] It has been shown that by taking the hair growth promoting composition of the present invention, scalp conditions are improved safely and in a short period of time without any side effects, promoting hair growth, and improving hair firmness, strength, luster, thickness, number, etc.

Claims

1. A composition for promoting hair growth, comprising an eggshell membrane component and a pea sprout extract.

2. The hair growth promoting composition according to claim 1, wherein the eggshell membrane component comprises a hydrolyzed eggshell membrane component and the pea sprout extract is pea sprout extract powder.

3. The hair growth promoting composition according to claim 1, comprising an egg white component which is egg white powder and / or egg white peptides.

4. The hair growth promoting composition according to claim 3, further comprising egg yolk oil and / or eggshell calcium.

5. A hair growth promoting composition according to any one of claims 1 to 4, which is for oral administration.

6. A food, drink or supplement comprising the hair growth promoting composition according to claim 5.

7. The food, drink or supplement according to claim 6, which is in the form of granules, tablets, capsules, liquid or drinkable preparations.

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