Chromosome detection assay

Abstract

Characterisation of chromosome interactions relating to ageing has found that they occur in clusters, with each cluster reflecting an underlying biological system that is involved in an ageing system. This work provides elucidation of the multi-layered and multidimensional nature of ageing. Therefore the invention provides a way of determining system-specific ageing and further allows adoption of intervention strategies to help inhibit or reverse the ageing process in a manner which is tailored to the needs of the individual. Essentially the invention provides a method for determining ageing by analysing chromosome interactions.

Description

[0001] CHROMOSOME DETECTION ASSAY Field of the Invention The invention relates to the ageing process. Background of the Invention Many current theories of ageing are focused on a ‘damage concept’, whereby the accumulation of damage (such as DNA oxidation) may cause biological systems to fail. Ageing leads to a gradual decrease in physical and mental capacity, a growing risk of disease and ultimately death. These changes are neither linear nor consistent, and they are only loosely associated with a person’s age in years. Summary of the Invention The inventors have identified and characterised chromosome interactions (3C / EpiSwitch) markers that can be used to measure the degree of ageing in individuals. The markers reflect changes in the 3D architecture of the chromosomes, and such chromosome interaction markers represent an independent regulatory system that does not directly correlate with any other marker, such as protein or nucleic acid molecular markers (including DNA methylation markers). Characterisation of the chromosome interactions relating to ageing has also found that they occur in clusters, with each cluster reflecting an underlying biological system that is involved in an ageing system. This analysis provides elucidation of the multi-layered and multidimensional nature of ageing. Therefore the invention provides a way of determining system-specific ageing and further allows adoption of intervention strategies to help inhibit or reverse the ageing process in a manner which is tailored to the needs of the individual. Accordingly, the invention provides a method of determining ageing in an individual, comprising detecting the presence or absence of one or more chromosome interactions shown in any of Tables 1 to 15, to thereby determine said ageing in the individual, wherein optionally a multidimensional measure of ageing is determined by detecting the presence or absence of one or more chromosome interactions from more than one of tables 1 to 15. [Tables 1 to 15 show the chromosome interactions from each cluster.] In one preferred aspect the presence or absence of the chromosome interactions of tables 28 and 30 are detected. Brief Description of the Drawings Figure 1 shows the 1096 CCSs that were found to meet the statistical criteria for this study. The figure shows the 150 CCSs that increased in abundance over time, the remaining 946 went down over time. The X axis shows time and the Y axis shows FC (CCSs up over time) Figure 2 shows the 150 CCSs increasing over time further split using Quality Threshold (QT) Clustering, producing 5 clusters (with the QT radius set to 1). The Slope Coef relates to the gradient of change with each set, and cluster 3 shows the greatest change over time. The X axis shows time and the Y axis shows FC. A shows cluster 1. The slope Coef is 0.173, and there are 64 CCSs. B shows cluster 2. The slope Coef is 0.17 and there are 51 CCSs. C shows cluster 3. The slope Coef is 0.176 and there are 15 CCSs. D shows cluster 4. The slope Coef is 0.168 and there are 14 CCSs. E shows cluster 5. The slope Coef is 0161 and there are 6 CCSs. Figure 3 shows 946 CCSs decreased their abundance with age. The majority of the significant 1096, decrease with time. The X axis shows time and the Y axis shows FC. Figure 4 shows the 946 CCSs decreasing with age further split using Quality Threshold (QT) Clustering, producing 10 clusters (QT radius set to 1.1). The Slope Coef relates to the gradient of change with each set, and cluster 5 shows the greatest change over age in this set. The X axis shows time and the Y axis shows FC. A shows cluster 1. The slope Coef is -0.177 and there are 231 CCSs. B shows cluster 2. The slope Coef is -0.179 and there are 226 CCSs. C shows cluster 3. The slope Coef is -0.19 and there are 157 CCSs. D shows cluster 4. The slope Coef is -0.187 and there are 122 CCSs. E shows cluster 5. The slope Coef is -0.21 and there are 61 CCSs. Figure 5 shows the remaining 5 clusters of the 10 clusters (QT radius set to 1.1.) formed using the 946 CCSs that decrease in abundance over age. Cluster 7 shows the greatest change over age in this set. The X axis shows time and the Y axis shows FC. A shows cluster 6. The slope Coef is -0.178 and there are 53 CCSs. B shows cluster 7. The slope Coef is -0.204 and there are 50 CCSs. C shows cluster 8. The slope Coef is -0.183 and there are 33 CCSs. D shows cluster 9. The slope Coef is -0.183 and the number of CCSs is 7. E shows cluster 10. The slope Coef is -0.182 and there are 6 CCSs. Figure 6 shows a preferred method of typing chromosome interactions. Description of the Tables Tables 1 to 5 show chromosome interactions which increase with age. Tables 6 to 15 shows chromosome interactions which decrease with age. Table 16 shows probes corresponding to the chromosome interactions of tables 1 to 15. Table 17 shows the groups of individuals that were studied in the present work. Table 18 shows the 150 CCSs increasing over age mapped to their closest coding loci (upstream, downstream, and overlapping). Biological pathway and disease enrichment analysis were performed on the basis of identified coding loci (genes). Table 19 shows disease ontologies with enriched loci from the 150 CCS increasing over time. Table 20 shows the pathways enrichment for the 64 CCSs in Cluster 1 of the CCSs that increase over time. Table 21 shows the pathways enrichment for the 51 CCSs in Cluster 2 of the CCSs that increase over time. [NRF2 is involved in redox regulation in ageing and disease] Table 22 shows the pathways enrichment for the combined 35 CCSs of clusters 3, 4 and 5. Table 23 shows pathway enrichment for the coding loci that map to the 946 CCSs that decrease over age. Table 24 shows the pathway enrichment for the CCSs (cluster 5) with the greatest decrease over age. Table 25 shows the pathway enrichment for the CCSs (cluster 7) with the next greatest decrease over age. Table 26 shows cluster 2 ‘age down’ (decrease with age) CCSs used for LDA. Table 27 and 28 show the same group of 135 markers which decrease with age. Table 29 and 30 show the same group of 42 markers which increase with age. Detailed Description of the Invention Terms Used Herein The method of the invention may be referred to as the ‘process’ of the invention herein. The chromosome interactions which are typed may be referred to as ‘markers’, ‘CCS’, ‘chromosome conformation signature’, ‘epigenetic interaction’ or ‘EpiSwitch markers’ herein. These are discussed in more detail below, and represent the coming together of different regions of a chromosome in a stable manner, which for example can be detected using a 3C assay. Chromosome interactions are shown in the tables herein and are defined with reference to their chromosomal location and the sequences in the two regions which have come together (for example by means of a probe sequence which recognises both sequences within the ligated nucleic acid formed by the 3C method). The name of each probe shows the chromosome number and the chromosome position numbers of the two regions which form the interaction. Therefore any specific chromosome interaction can be defined in any of the following 3 ways: - the chromosome interaction that is shown in table ‘X’ - the chromosome interaction represented by a ‘specific probe sequence’ - the chromosome interaction which is formed by chromosome regions ‘X to X’ and ‘X to X’ coming together. The word ‘type’ will be interpreted as per the context, but will usually refer to detection of whether a specific chromosome interaction is present or absent. The typing will usually comprise physical detection of the presence or absence of a chromosome interaction. The chromosome interaction markers of the invention have been found to fall into ‘clusters’, and each cluster is shown in tables 1 to 15 which are discussed in more detail below. Each cluster is specific to a biological system related to ageing. Tables 1 to 5 shows clusters 1 to 5 which increase with age. Tables 6 to 15 show clusters 1 to 10 which decrease with age. Tables 27 to 30 show preferred chromosome interaction markers. These chromosome interactions are a subset of those shown in tables 1 to 15. Tables 27 and 28 show information for the same set of markers and these decrease with age. Tables 29 and 30 show information for the same set of markers, and these increase with age. The term ‘multidimensional’ is used to describe a readout which reflects ageing in more than one biological system and a multidimensional readout can be obtained by typing chromosome interactions in more than one cluster. In certain aspects ‘combinations’ of chromosome interactions are typed. Some combinations will provide a readout which is a measure of ageing in a single system, whereas others will provide a readout of ageing in more than one system (i.e. a multidimensional readout). It will be understood that combinations of chromosome in one context is applicable to all other contexts. Where there is a reference to a specific number of chromosome interactions, for example 5 chromosome interactions to be typed, it will be assumed this means the specified chromosome interactions are different, for example 5 different chromosome interactions. In references to ‘top’ markers, these refer to a group of markers selected from a given table which occur at the top of the table. Preferably these will be the top 10 markers, i.e. markers to 1 to 10 at the top of the table. Preferably these will be the top 10 markers at the top of the tables 1 to 15. Several aspects of the invention are defined with reference to a species. This includes the chromosome interactions and all nucleic acids which can be of any species or classes of species (e.g. mammals) mentioned herein. A preferred species is human, including for the individual which is tested and / or treated. Technical Overview Healthy ageing is a natural biological process, associated with complex changes in the body with time, well recognized through its common manifestations of changes in such tissues and organs as skin, muscle, central nervous system, immune system, etc. By itself healthy ageing, as a natural process, and despite all its features, could not be considered a clinical condition or a disease. Like many other aspects of health risks, age is sometimes recognized as a risk factor, associated with particular diseases, for example dementia and neurodegeneration. Ageing can be understood in terms of cellular and molecular regulatory events. At the cellular level, replicative life span – cellular potential for a number of divisions it can undergo in the context of the organisms, and chronological life span – a time for a quiescent cell to stay alive after its last division, both are considered to contribute to the ageing process. At the molecular level, length of telomeres at the chromosomal ends is indicative of replicative potential of cells and thus overall ageing outcome. There are conflicting reports of how DNA methylation is associated with ageing, including increased or decreased association with age, increased entropy and progression of high- and low- methylated CpGs to an intermediate level around 50% methylation with age. As part of performing the work that led to the invention the following question was asked by the inventors: could we discover and evaluate within healthy population conditional chromosome conformations, which consistently change with time in the normal healthy process of ageing and could thus act as a reference points or milestones in the ageing process? The complexity of 3D genome architecture is vast (with over 1.2 million anchoring sites, engaged in multiple choices of long range interactions). In order to attempt a discovery of any statistically significant age-related changes in 3D genome architecture (if any), we had to use a very specific methodology as described in the Figures and Examples. The inventors’ work led to discovery of clusters of 3D genome architecture manifested through specific architecture chromosome conformations, that increase or decrease their abundance in blood of individuals with age. These clusters define 3D genomic regulation over specific groups of biological pathways, genes and controls which appear synchronized at the rate of their changes. Each cluster profile acts as reference point for an assessment of biological ageing in an individual, defined within the group of pathways and genes it includes. Altogether, an individual can therefore be profiled by 3D genomics across the whole genome. The abundance of individual chromosome conformations can be compared to the profiles across age groups, cluster by cluster. This defines in each group of biological clusters, the biological age against the average signal distribution. Within the remit of healthy ageing, without resorting to the disease diagnosis, one can evaluate progression for each of the clusters through the natural trend of signal increase or decrease. The Epigenetic Interactions Relevant to the Invention The chromosome interactions which are typed in the invention are typically stable interactions between distal regions of a chromosome which depend upon the state of the region of the chromosome. That state will reflect different aspects of the ageing process, and therefore the invention can be carried out to detect the extent of ageing, for example healthy ageing. The chromosome interaction may, for example, reflect if a gene region is being transcribed or repressed. Chromosome interactions which are specific to ageing subgroups as defined herein have been found to be stable, thus providing a reliable means of measuring the differences between the two subgroups (for example reflecting different rates of ageing). Chromosome interactions specific to ageing will normally occur early in the ageing process, for example compared to other epigenetic markers such as methylation or changes to binding of histone proteins. Thus the process of the invention is able to detect ageing at an early stage. This allows early intervention (for example treatment) which as a consequence will be more effective. Chromosome interactions also reflect the current state of the individual and therefore can be used to assess changes to the ageing process. Furthermore there is little variation in the relevant chromosome interactions between individuals within the same subgroup. Detecting chromosome interactions is highly informative with up to 50 different possible interactions per gene. Chromosomal interactions may overlap and include the regions of chromosomes shown to encode relevant or undescribed genes, but equally may be in intergenic regions. It should further be noted that the inventors have discovered that chromosome interactions in all regions are equally important in determining the status of a chromosomal locus. The chromosome interactions which are detected in the invention could be impacted by changes to the underlying DNA sequence, by environmental factors, DNA methylation, non-coding antisense RNA transcripts, non-mutagenic carcinogens, histone modifications, chromatin remodelling and specific local DNA interactions. However it must be borne in mind that chromosome interactions as defined herein are a regulatory modality in their own right and do not have a one to one correspondence with any genetic marker (DNA sequence change) or any other epigenetic marker. The chromosome interaction which is detected in the method of the invention can be in any gene, chromosome region defined in the tables, or in any pathway shown herein (for example in any gene in such a pathway). Chromosome interactions may be impacted by changes to the underlying nucleic acid sequence which themselves do not directly affect a gene product or the mode of gene expression. Such changes may be for example, SNPs within and / or outside of the genes, gene fusions and / or deletions of intergenic DNA, microRNA, and non-coding RNA. For example, it is known that roughly 20% of SNPs are in non-coding regions, and therefore the process as described is also informative in non- coding situation. In one aspect the regions of the chromosome which come together to form the interaction are less than 5 kb, 3 kb, 1 kb, 500 base pairs or 200 base pairs apart on the same chromosome. The chromosome interaction which is detected may be within a gene, such as any gene mentioned herein. However it may also be upstream or downstream of the gene, for example up to 50,000, up to 30,000, up to 20,000, up to 10,000 or up to 5000 bases upstream or downstream from the gene or from the coding sequence. The Process of the Invention The process of the invention comprises a typing system for detecting chromosome interactions relevant to ageing. Any suitable typing method can be used, for example a method in which the proximity of the chromosomes in the interaction is detected. The typing method may be performed using the EpiSwitch™ system mentioned herein which for example may be carried out by a method comprising the following steps (for example on a sample from the subject): (i) cross-linking regions of chromosome which have come together in a chromosome interaction, (ii) optionally isolating the cross-linked DNA from said chromosomal locus (iii) subjecting the cross-linked DNA to cleavage, and (iv) ligating the nucleic acids present in the cross-linked entity to derive a ligated nucleic acid with sequence from both the regions which formed a chromosomal interaction. Detection of this ligated nucleic acid allows determination of the presence or absence of a particular chromosome interaction. The ligated nucleic acid therefore acts as a marker for the presence of the chromosome interaction. Preferably the ligated nucleic acid is detected by PCR or a probe based method, including a qPCR method. In the method the chromosomes can be cross-linked by any suitable means, for example by a cross- linking agent, which is typically a chemical compound. In a preferred aspect, the interactions are cross-linked using formaldehyde, but may also be cross-linked by any aldehyde, or D-Biotinoyl-e- aminocaproic acid-N-hydroxysuccinimide ester or Digoxigenin-3-O-methylcarbonyl-e-aminocaproic acid-N-hydroxysuccinimide ester. Para-formaldehyde can cross link DNA chains which are 4 Angstroms apart. Preferably the chromosome interactions are on the same chromosome. Typically the chromosome interactions are 2 to 10 Angstroms apart. The cross-linking is preferably in vitro. The cleaving is preferably by restriction digestion with an enzyme, such as TaqI. The ligating may form DNA loops. Where PCR (polymerase chain reaction) is used to detect or identify the ligated nucleic acid, the size of the PCR product produced may be indicative of the specific chromosome interaction which is present, and may therefore be used to identify the status of the locus. Where a probe is used to detect or identify the ligated nucleic acid this is generally by Watson-Crick based base-pairing between the probe and ligated nucleic acid. Probe sequences as shown in any table herein may be used, for example the probe sequences shown in Table 16 (corresponding to the chromosome interaction which is being detected). Homologues of such probe sequences may also be used, which can have at least 70% identity to the original sequence. Typing according to the process of the invention may be carried out at multiple time points, for example to monitor the progression of ageing. This may be at one or more defined time points, for example at at least 1, 2, 5, 8 or 10 different time points. The durations between at least 1, 2, 5 or 8 of the time points may be at least 5, 10, 20, 50, 80 or 100 days. Typically there are at least 2 time points which are 30 days apart from each other, and so for example samples are taken from the individual at these 2 time points. There may be at least 3 time points each at least 50 days apart from each other. Subgroups and Personalised Treatment As used herein, a “subgroup” preferably refers to a population subgroup, more preferably a subgroup in the population of a particular organism such as a particular eukaryote, animal, bird or mammal. Most preferably, a “subgroup” refers to a subgroup in the human population. Therefore the process of the invention is preferably carried out to determine ageing in a eukaryote, such as an animal, mammal or bird, and preferably in a human. The invention includes detecting and treating particular subgroups in a population, typically differing in their ageing. The inventors have discovered that chromosome interactions differ between subsets (for example at least two subsets) in the relevant population. Identifying these differences will allow physicians to categorize individuals as a part of one subset of the population. The invention therefore provides physicians with a process of personalizing intervention, treatment or medicine for the individual based on their chromosome interactions. Such testing may be used to select how to subsequently treat the patient, for example the type of intervention, such as the drug and / or its dose and / or its frequency of administration. In this sense the invention could be viewed as a method of selecting an individual that will be provided with an anti-ageing intervention. The invention provides different types of personalized treatment. In one aspect an individual is given or not given therapy based on the results of the method of the invention, i.e. based on the detecting of the presence or absence one or more specific chromosome interactions. The method of the invention is in this sense typically allowing selection of a therapy based on the individual’s determined ageing. The Individual That is Tested The individual that is tested in the process of the invention may have been selected in some way, for example based on a risk factor or physical characteristic. The individual may have been selected based on being symptomless for a given disease, or being in the early stages of the disease or having a mild form of the disease. The individual may be susceptible to any condition mentioned herein and / or may be in need of any therapy mentioned in. The individual may be receiving any therapy mentioned herein. In particular, the individual may have, or be suspected of having, accelerated ageing. The individual may be at least 40 years old, for example at least 50, 60, 70 or 80 years old. The individual may have one or more of the following characteristics: - the individual may have a sign (or symptom) of an advanced ageing process, which is preferably one or more of (i) decline in energy and / or muscle tone, (ii) cognitive stumbles, (iii) change in sleeping pattern; - the individual may have a risk scope associated with advanced ageing; and / or - the individual may be on a treatment or procedure associated with anti-ageing, which is preferably resveratrol, NMN, NAD+, Ginseng or blood transfusion; and / or - the individual may wish to monitor the achieved effect against the systemic age-related scale of ageing, measured through the defined clusters of 3D genomic architecture biomarkers, that represent synchronized regulatory changes associated with age groups. The Measure of Ageing which is Determined The process of the invention typically determines the extent or rate of ageing, for example in one or more biological systems as mentioned herein. Preferably ageing in such systems is determined by typing the chromosome interactions mentioned in each of tables 1 to 15, as each of these tables corresponds to a biological system. The process of the invention can therefore be used to determine, for example, whether accelerated ageing is occurring in one or more systems. The process of the invention can be used to determine whether an intervention is required to reduce or reverse the ageing process. Tables Provided Herein Tables 1 to 15 show groups of chromosome interaction markers, with each of these tables corresponding to a biological system. Each marker can be used to detect ageing, i.e. their presence or absence can be used in such a detection (i.e. they are ‘disseminating’ markers). Tables 1 to 5 show markers which increase with ageing (in ‘age up’ clusters 1 to 5), and tables 6 to 15 show markers which decrease with age (in ‘age down’ clusters 1 to 10). The ‘distance’ figure shown in the tables is in number of nucleotide bases. Analysis by individual clusters is an important aspect of the invention. Each cluster of the markers comprise changes that take place at the same rate with time. The tables list the markers in order of statistical significance across the whole set. The top 10 markers for each cluster are preferred (starting from the top of the table). Typing of a selection of markers from a cluster (for example the top 10) will show the state of the whole cluster and also if development of associated diseases is taking place. There are 5 cluster of significant markers that accumulate with age, and 10 clusters of significant markers that diminish and disappear with age. Preferred chromosome interaction markers are shown in tables 28 and 30. The data is normalised together, but the separate groups for the different time groups are extracted in order to do the cluster analysis. There are 4 different patients in each age group, the clustering is done on the average of the normalised patients. The P-value is generated from the linear regression of the CCS over time, which is a continuous covariate, which means there is a linear response to time (for example CCSs that go up or down as time progresses). As such one assumes no change over time (which is the null hypothesis). The intercept for each fit (CCS) gives the fold change that is generated, CCS over time, compared to trend of change. The FC value shows abundance change. The adjusted p-value is corrected using Benjamini & Hochberg, false discovery on the CCSs that are found to have significant change over time. Table 16 shows probe sequences. The probe name shows the chromosomal location of the relevant interaction using chromosome position numbers. Table 16a shows the ‘ageing up’ sequences and Table 16b shows the ‘ageing down’ probe sequences. The probes are designed to be 30bp away from the Taq1 site. In case of PCR, PCR primers are typically designed to detect ligated product but their locations from the Taq1 site vary. Probe locations: Start 1 - 30 bases upstream of TaqI site on fragment 1 End 1 - TaqI restriction site on fragment 1 Start 2 - TaqI restriction site on fragment 2 End 2 - 30 bases downstream of TaqI site on fragment 2 4kb Sequence Location: Start 1 - 4000 bases upstream of TaqI site on fragment 1 End 1 - TaqI restriction site on fragment 1 Start 2 - TaqI restriction site on fragment 2 End 2 - 4000 bases downstream of TaqI site on fragment 2 Preferred Marker Sets (i.e. Combinations of Markers to be Typed) Typing a very low number of the markers disclosed herein will result in an effective test due to the nature of regulation by chromosome interactions, including their network-like properties. The different numbers and combination of markers give rise to different performance properties, as well as multidimensional measures of ageing. The chromosome interactions which are typed include those which are specifically mentioned in any table. Chromosome interactions which are present in genes and regions mentioned in the tables may also be typed. Specific markers are defined herein by location or by probe sequence. Tables 1 to 15 list the chromosome interactions in order of preference, with those at the top of the table preferred over those which are listed below. Where there is a reference to ‘top X number of markers’ herein this means the ‘X’ number of markers which are listed at the top of the table. Preferably the top 10 markers of any table are typed. The invention includes typing at least 5, 10, 15, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140 or 150 of the chromosome interactions listed in any of tables 1 to 15. The invention includes typing at least 5, 10, 15, 20 or 30 of the chromosome interactions listed in any one of tables 1 to 15. The invention includes typing at least 5, 10, 15, 20, 30, 40, 50, 60 or 70 of the chromosome interactions which represent the top 10 chromosome interactions listed in any of tables 1 to 15. The invention includes typing at least 5, 10, 15 or 20 chromosome interactions from each of tables 1 to 15 (i.e. at least 5, 10, 15 or 20 from table 1, at least 5, 10, 15 or 20 from table 2, etc). The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 1. At least all of the top 15, top 10 or top 5 markers of table 1 may be preferably typed. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 2. At least all of the top 15, top 10 or top 5 markers of table 2 may be preferably typed. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 3. At least all of the top 15, top 10 or top 5 markers of table 3 may be preferably typed. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 4. At least all of the top 15, top 10 or top 5 markers of table 4 may be preferably typed. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 5. At least all of the top 15, top 10 or top 5 markers of table 5 may be preferably typed. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 6. At least all of the top 15, top 10 or top 5 markers of table 6 may be preferably typed. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 7. At least all of the top 15, top 10 or top 5 markers of table 7 may be preferably typed. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 8. At least all of the top 15, top 10 or top 5 markers of table 8 may be preferably typed. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 9. At least all of the top 15, top 10 or top 5 markers of table 9 may be preferably typed. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 10. At least all of the top 15, top 10 or top 5 markers of table 10 may be preferably typed. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 11. At least all of the top 15, top 10 or top 5 markers of table 1 may be preferably typed 11. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 12. At least all of the top 15, top 10 or top 5 markers of table 12 may be preferably typed. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 13. At least all of the top 15, top 10 or top 5 markers of table 13 may be preferably typed. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 14. At least all of the top 15, top 10 or top 5 markers of table 14 may be preferably typed. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 15. At least all of the top 15, top 10 or top 5 markers of table 15 may be preferably typed. The invention includes preferably typing at least 5 or at least 8 of the top 10 markers from at least 1, 2, 5, 8, 10, 12 or all of tables 1 to 15. The invention includes typing at least all of the top 10 markers from at least 1, 2, 5, 8, 10, 12 or all of tables 1 to 15. The invention includes typing at least all of the top 10 markers from all of tables 1 to 15. The invention includes typing at least all of the top 20 markers from all of tables 1 to 15. The invention includes typing at least all of the markers from all of tables 1 to 15. In one aspect one or more chromosome interactions are typed which: (i) are present in any one of the genes listed in any of tables 1 to 15; and / or (ii) corresponds to any one of the chromosome interactions shown in tables 1 to 15; and / or (iii) is present in a 4,000 base region which comprises or which flanks (i) or (ii). The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 28. The invention includes typing all of the chromosome interactions as listed in table 28. The invention includes typing at least 1, 5, 10, 15 or 20 of chromosome interactions as listed in table 30. The invention includes typing all of the chromosome interactions as listed in table 30. Types of Chromosome Interaction In one aspect the locus (including the gene and / or place where the chromosome interaction is detected) may comprise a CTCF binding site. This is any sequence capable of binding transcription repressor CTCF. That sequence may consist of or comprise the sequence CCCTC which may be present in 1, 2 or 3 copies at the locus. The CTCF binding site sequence may comprise the sequence CCGCGNGGNGGCAG (in IUPAC notation). The CTCF binding site may be within at least 100, 500, 1000 or 4000 bases of the chromosome interaction. When detection is performed using a probe, typically sequence from both regions of the probe (i.e. from both sites of the chromosome interaction) is detected. In preferred aspects probes are used in the process which comprise or consist of the same or complementary sequence to a probe shown in any table. In some aspects probes are used which comprise sequence which is homologous to any of the probe sequences shown in the tables. The Approach Taken to Identify Markers and Panels of Markers The invention described herein relates to chromosome conformation profile and 3D architecture as a regulatory modality in its own right, closely linked to the ageing phenotype. The discovery of biomarkers was based on annotations through pattern recognition and screening on representative cohorts of clinical samples representing the differences in phenotypes. We annotated and screened significant parts of the genome, across coding and non-coding parts and over large sways of non- coding 5’ and 3’ of known genes for identification of statistically disseminating consistent conditional disseminating chromosome conformations, which for example anchor in the non-coding sites within (intronic) or outside of open reading frames. In selection of the best markers we are driven by statistical data and p values for the marker leads. Selected and validated chromosome conformations within the signature are disseminating stratifying entities in their own right, irrespective of the expression profiles of the genes used in the reference. Further work may be done on relevant regulatory modalities, such as SNPs at the anchoring sites, changes in gene transcription profiles, changes at the level of H3K27ac. We are taking the question of clinical phenotype differences and their stratification from the basis of fundamental biology and epigenetic controls over phenotype - including for example from the framework of network of regulation. As such, to assist stratification, one can capture changes in the network and it is preferably done through signatures of several biomarkers, for example through following a machine learning algorithm for marker reduction which includes evaluating the optimal number of markers to stratify the testing cohort with minimal noise. This may end with 3-20 markers typically. Selection of markers for panels may be done by cross-validation statistical performance (and not for example by the functional relevance of the neighbouring genes, used for the reference name). A panel of markers (with names of adjacent genes) is a product of clustered selection from the screening across significant parts of the genome, in non-biased way analysing statistical disseminating powers over 14,000-60,000 annotated EpiSwitch sites across significant parts of the genome. It should not be perceived as a tailored capture of a chromosome conformation on the gene of know functional value for the question of stratification. The total number of sites for chromosome interaction are 1.2 million, and so the potential number of combinations is 1.2 million to the power 1.2 million. The approach that we have followed nevertheless allows the identifying of the relevant chromosome interactions. The specific markers that are provided by this application have passed selection, being statistically (significantly) associated with the ageing subgroup. This is what the data in the relevant table demonstrates. Each marker can be seen as representing an event of biological significance, for example as part of network deregulation, that is manifested in ageing. In practical terms it means that these markers are present or absent across groups of individuals when compared to controls. On average, as an example, an individual marker whose presence is associated with ageing may typically be present in 80% of individuals tested and in 10% of controls tested. On average, as an example, an individual marker whose absences is associated with ageing may typically be absent in 80% of individuals tested and in 10% of controls tested. The markers which are disclosed herein have been found to be ‘disseminating markers’ capable of determining ageing status or subgroup. As mentioned above, it means that these markers are more prevalent or less prevalent across groups of individuals when compared to controls (as is shown by the FC value, for example). Thus in one aspect of the method an individual is deemed to be part of the relevant age subgroup if least 80% of the markers of tables 1 to 5 that are tested are present in the individual and / or if at least 80% of the markers of tables 6 to 15 that are tested are absent from the individual. In one aspect of the method an individual is deemed to be part of the relevant age subgroup if least 80% of the markers of table 28 that are tested are absent in the individual and / or if at least 80% of the markers of table 30 that are tested are present in the individual. Simple addition of all markers would not directly represent the network interrelationships between some of the changes (for example deregulations). This is where the standard multivariate biomarker analysis GLMNET (R package) can be brought in. GLMNET package helps to identify interdependence between some of the markers, that reflect their joint role in achieving deregulations leading to disease phenotype. Modelling and then testing markers with highest GLMNET scores offers not only identify the minimal number of markers that accurately identifies the patient cohort, but also the minimal number that offers the least false positive results in the control group of patients, due to background statistical noise of low prevalence in the control group. Typically a group (combination) of selected markers (such as 3 to 10) offers the best balance between both sensitivity and specificity of detection, emerging in the context of multivariate analysis from individual properties of all the selected statistical significant markers for the condition. The tables herein show the probe name which is used to define the chromosome interaction. The name of the probe gives the chromosome position numbers of the two regions which are recognised by the relevant probe, providing an alternative way of defining the chromosome interaction in a unique way. Samples and Sample Treatment The process of the invention will normally be carried out on a sample, for example obtained from the individual to be tested. The sample may be obtained at a defined time point, for example at any time point defined herein. The sample will normally contain DNA from the individual. It will normally contain cells. In one aspect a sample is obtained by minimally invasive means, and may for example be a blood sample. DNA may be extracted and cut up with a standard restriction enzyme. This can pre-determine which chromosome conformations are retained and will be detected with the EpiSwitchTMplatforms. Due to the synchronisation of chromosome interactions between tissues and blood, including horizontal transfer, a blood sample can be used to detect the chromosome interactions in tissues, such as tissues relevant to disease. Preferred Aspects for Sample Preparation and Chromosome Interaction Detection Methods of preparing samples and detecting chromosome conformations are described herein. Optimised (non-conventional) versions of these processes can be used, for example as described in this section. Typically the sample will contain at least 2 x105cells. The sample may contain up to 5 x105cells. In one aspect, the sample will contain 2 x105to 5.5 x105cells. Crosslinking of epigenetic chromosomal interactions present at the chromosomal locus is described herein. This may be performed before cell lysis takes place. Cell lysis may be performed for 3 to 7 minutes, such as 4 to 6 or about 5 minutes. In some aspects, cell lysis is performed for at least 5 minutes and for less than 10 minutes. Digesting DNA with a restriction enzyme is described herein. Typically, DNA restriction is performed at about 55oC to about 70oC, such as for about 65oC, for a period of about 10 to 30 minutes, such as about 20 minutes. Preferably a frequent cutter restriction enzyme is used which results in fragments of ligated DNA with an average fragment size up to 4000 base pair. Optionally the restriction enzyme results in fragments of ligated DNA have an average fragment size of about 200 to 300 base pairs, such as about 256 base pairs. In one aspect, the typical fragment size is from 200 base pairs to 4,000 base pairs, such as 400 to 2,000 or 500 to 1,000 base pairs. In one aspect of the EpiSwitch process a DNA precipitation step is not performed between the DNA restriction digest step and the DNA ligation step. DNA ligation is described herein. Typically the DNA ligation is performed for 5 to 30 minutes, such as about 10 minutes. The protein in the sample may be digested enzymatically, for example using a proteinase, optionally Proteinase K. The protein may be enzymatically digested for a period of about 30 minutes to 1 hour, for example for about 45 minutes. In one aspect after digestion of the protein, for example Proteinase K digestion, there is no cross-link reversal or phenol DNA extraction step. In one aspect PCR detection is capable of detecting a single copy of the ligated nucleic acid, preferably with a binary read-out for presence / absence of the ligated nucleic acid. Processes and Uses of the Invention The process of the invention can be described in different ways. It can be described as a process of making a ligated nucleic acid comprising (i) in vitro cross-linking of chromosome regions which have come together in a chromosome interaction; (ii) subjecting said cross-linked DNA to cutting or restriction digestion cleavage; and (iii) ligating said cross-linked cleaved DNA ends to form a ligated nucleic acid, wherein detection of the ligated nucleic acid may be used to determine the chromosome state at a locus, and wherein preferably: - the locus may be any of the genes mentioned in any of tables 1 to 15; and / or - wherein the chromosomal interaction may be any of the chromosome interactions mentioned herein in any table; and / or - wherein the ligated product may have or comprise (i) sequence which is the same as or homologous to any of the probe sequences disclosed in Table 16; or (ii) sequence which is complementary to (ii). The process of the invention can be described as a process for detecting chromosome states which represent different subgroups in a population comprising determining whether a chromosome interaction is present or absent within a defined epigenetically active region of the genome, wherein preferably the subgroup is defined by ageing. Homologues Homologues of polynucleotide / nucleic acid (e.g. DNA) sequences are referred to herein. Such homologues typically have at least 70% homology, preferably at least 80%, at least 85%, at least 90%, at least 95%, at least 97%, at least 98% or at least 99% homology, for example over a region of at least 10, 15, 20, 30, 100 or more contiguous nucleotides, or across the portion of the nucleic acid which is from the region of the chromosome involved in the chromosome interaction. The homology may be calculated on the basis of nucleotide identity (sometimes referred to as "hard homology"). Therefore, in a particular aspect, homologues of polynucleotide / nucleic acid (e.g. DNA) sequences are referred to herein by reference to percentage sequence identity. Typically such homologues have at least 70% sequence identity, preferably at least 80%, at least 85%, at least 90%, at least 95%, at least 97%, at least 98% or at least 99% sequence identity, for example over a region of at least 10, 15, 20, 30, 100 or more contiguous nucleotides, or across the portion of the nucleic acid which is from the region of the chromosome involved in the chromosome interaction. The homologues may have at least 70% sequence identity, preferably at least 80%, at least 85%, at least 90%, at least 95%, at least 97%, at least 98% or at least 99% sequence identity across the entire probe, primer or primer pair. For example the UWGCG Package provides the BESTFIT program which can be used to calculate homology and / or % sequence identity (for example used on its default settings) (Devereux et al (1984) Nucleic Acids Research 12, p387-395). The PILEUP and BLAST algorithms can be used to calculate homology and / or % sequence identity and / or line up sequences (such as identifying equivalent or corresponding sequences (typically on their default settings)), for example as described in Altschul S. F. (1993) J MoI Evol 36:290-300; Altschul, S, F et al (1990) J MoI Biol 215:403- 10. Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information. This algorithm involves first identifying high scoring sequence pair (HSPs) by identifying short words of length W in the query sequence that either match or satisfy some positive-valued threshold score T when aligned with a word of the same length in a database sequence. T is referred to as the neighbourhood word score threshold (Altschul et al, supra). These initial neighbourhood word hits act as seeds for initiating searches to find HSPs containing them. The word hits are extended in both directions along each sequence for as far as the cumulative alignment score can be increased. Extensions for the word hits in each direction are halted when: the cumulative alignment score falls off by the quantity X from its maximum achieved value; the cumulative score goes to zero or below, due to the accumulation of one or more negative-scoring residue alignments; or the end of either sequence is reached. The BLAST algorithm parameters W5 T and X determine the sensitivity and speed of the alignment. The BLAST program uses as defaults a word length (W) of 11, the BLOSUM62 scoring matrix (see Henikoff and Henikoff (1992) Proc. Natl. Acad. Sci. USA 89: 10915-10919) alignments (B) of 50, expectation (E) of 10, M=5, N=4, and a comparison of both strands. The BLAST algorithm performs a statistical analysis of the similarity between two sequences; see e.g., Karlin and Altschul (1993) Proc. Natl. Acad. Sci. USA 90: 5873-5787. One measure of similarity provided by the BLAST algorithm is the smallest sum probability (P(N)), which provides an indication of the probability by which a match between two polynucleotide sequences would occur by chance. For example, a sequence is considered similar to another sequence if the smallest sum probability in comparison of the first sequence to the second sequence is less than about 1, preferably less than about 0.1, more preferably less than about 0.01, and most preferably less than about 0.001. The homologous sequence typically differs by 1, 2, 3, 4 or more bases, such as less than 10, 15 or 20 bases (which may be substitutions, deletions or insertions of nucleotides). These changes may be measured across any of the regions mentioned above in relation to calculating homology and / or % percentage sequence identity. Homology of a ‘pair of primers’ can be calculated, for example, by considering the two sequences as a single sequence (as if the two sequences are joined together) for the purpose of then comparing against the another primer pair which again is considered as a single sequence. EpiSwitchTMTechnology The EpiSwitchTMTechnology also relates to the use of microarray EpiSwitchTMmarker data in the detection of epigenetic chromosome conformation signatures specific for phenotypes. Aspects such as EpiSwitchTMwhich utilise ligated nucleic acids in the manner described herein have several advantages. They have a low level of stochastic noise, for example because the nucleic acid sequences from the first set of nucleic acids of the present invention either hybridise or fail to hybridise with the second set of nucleic acids. This provides a binary result permitting a relatively simple way to measure a complex mechanism at the epigenetic level. EpiSwitchTMtechnology also has fast processing time and low cost. In one aspect the processing time is 3 hours to 6 hours. Arrays All nucleic acids disclosed herein may be bound to an array, and in one aspect there are at least 15,000, 45,000, 100,000 or 250,000 or 500,000 or 1,000,000 different nucleic acids bound to the array, which preferably represent at least 300, 900, 2000 or 5000 loci. In one aspect one, or more, or all of the different populations of nucleic acids are bound to more than one distinct region of the array, in effect repeated on the array allowing for error detection. The array may be based on an Agilent SurePrint G3 Custom CGH microarray platform. Detection of binding of first nucleic acids to the array may be performed by a dual colour system. Anti-Ageing Interventions, Agents and Treatments The invention includes providing an intervention to an individual based on, or in view of, the determination of ageing (i.e. the readout from the test of the invention). Typically the intervention is an ‘anti-ageing’ therapy, for example administration of a substance (agent) which is able to treat or reverse age-related symptoms, pathophysiology or conditions. Preferably the intervention is one which causes increase in life span, for example based on any mechanism mentioned herein or by a mechanism involving any gene mentioned herein. The intervention may reverse or inhibit any aspect of ageing mentioned herein. The intervention typically impacts metabolism. The intervention may be an anti-inflammatory. Preferably the agent is resveratrol or trans-resveratrol. The agent may be any of nicotinamide riboside (NR), vitamin B3 (NR alternative form), nicotinamide mononucleotide (NMN), nicotinamide adenine dinucleotide (NAD+), nicotinamide (NAM), nicotinic acid (NA), or a derivative or intermediate of any of these. The intervention may be a change in behaviour, for example a change in diet or life-style changes. Such a change may be caloric restriction, measures to reduce body weight or increased exercise. The invention includes providing advice to the individual in respect of any of these in view of the result of the determination of ageing. This may comprise administering to an individual in need a therapeutically effective amount of the agent. The invention provides use of the agent in the manufacture of a medicament to prevent or treat ageing in the individual and / or to prevent or treat a condition associated with ageing. The formulation of the agent will depend upon the nature of the agent. The agent will be provided in the form of a pharmaceutical composition containing the agent and a pharmaceutically acceptable carrier or diluent. Suitable carriers and diluents include isotonic saline solutions, for example phosphate-buffered saline. Typical oral dosage compositions include tablets, capsules, liquid solutions and liquid suspensions. The agent may be formulated for parenteral, intravenous, intramuscular, subcutaneous, transdermal or oral administration. The dose of an agent may be determined according to various parameters, especially according to the substance used; the age, weight and condition of the individual to be treated; the route of administration; and the required regimen. A physician will be able to determine the required route of administration and dosage for any particular agent. A suitable dose may however be from 0.1 to 100 mg / kg body weight such as 1 to 40 mg / kg body weight, for example, to be taken from 1 to 3 times daily. The invention includes a cosmetic method or use, where the intervention (for example the anti- ageing agent) is given or provided (or administered) for a cosmetic purpose, i.e. in respect of reducing or reversing a negative cosmetic effect of ageing. The invention includes use of anti-ageing intervention (such an anti-aging agent) for reducing or reversing a cosmetic effect of ageing, for example reducing or reversing a negative quality of physical appearance due to ageing. Such a quality may be sagging skin. Screening for Therapeutic Agents The invention provides a method of screening candidate agents (for example compounds) to determine whether they can be used as an anti-ageing agent. In one aspect the invention provides a method of determining whether a candidate agent is an anti- ageing agent comprising determining whether the candidate is able to alter one or more chromosome interactions disclosed herein, including the numbers and combinations of chromosome interaction disclosed herein. This method may determine whether the candidate agent is able create or destroy such interaction(s). In one aspect the invention provides a method for determining whether a candidate agent is an anti- ageing agent comprising; (i) contacting the candidate agent with one or more chromosomes, (ii) determining whether the candidate agent is able to create or destroy one or more chromosome interactions as shown in any one of tables 1 to 15, to thereby determine whether the candidate agent is an anti-ageing agent. Properties of Nucleic Acids of the Invention The invention relates to certain nucleic acids, for example probes or primers. The nucleic acids may be the ligated nucleic acids which are described herein as being used or generated in the process of the invention. The nucleic acids of the invention typically comprise two portions each comprising sequence from one of the two regions of the chromosome which come together in the chromosome interaction. Typically each portion is at least 8, 10, 15, 20, 30 or 40 nucleotides in length, for example 10 to 40 nucleotides in length. Preferred nucleic acids comprise sequence from any of the genes mentioned in any of the tables. Typically preferred nucleic acids comprise the specific probe sequences mentioned herein, for example in table 16; or fragments and / or homologues of such sequences. The ligated nucleic acids may comprise the sequence of any of the probe sequences disclosed herein. Preferably the nucleic acids are DNA. It is understood that where a specific sequence is provided the invention may use the complementary sequence as required in the particular aspect. The nucleic acids may be primers, for example to amplify the ligated sequences mentioned herein. The primers may comprise sequence from any of the probe sequences shown in table 16; or fragments and / or homologues of any such sequence. Library of Nucleic Acids Any of the types of nucleic acid populations mentioned herein may be present in the form of a library comprising at least 200, at least 500, at least 1000, at least 5000 or at least 10000 different nucleic acids. Such a library may be in the form of being bound to an array. The library may comprise all of the probe sequence from any of the tables disclosed herein. The library may be capable of detecting one or more of the chromosome interactions described herein. Labelled Nucleic Acids and Pattern of Hybridisation The nucleic acids mentioned herein may be labelled, preferably using an independent label such as a fluorophore (fluorescent molecule) or radioactive label which assists detection of successful hybridisation. Certain labels can be detected under UV light. The pattern of hybridisation, for example on an array described herein, represents differences in epigenetic chromosome interactions between the two subgroups, and thus provides a process of comparing epigenetic chromosome interactions and determination of which epigenetic chromosome interactions are specific to a subgroup in the population of the present invention. The term ‘pattern of hybridisation’ broadly covers the presence and absence of hybridisation, and so it not limited to any particular assay or technique, or the need to have a surface or array on which a ‘pattern’ can be detected. Forms of the Substance Mentioned Herein Any of the substances, such as nucleic acids or therapeutic agents, mentioned herein may be in purified or isolated form. They may be in a form which is different from that found in nature, for example they may be present in combination with other substance with which they do not occur in nature. The nucleic acids (including portions of sequences defined herein) may have sequences which are different to those found in nature, for example having at least 1, 2, 3, 4 or more nucleotide changes in the sequence as described in the section on homology. The nucleic acids may have heterologous sequence at the 5’ or 3’ end. The nucleic acids may be chemically different from those found in nature, for example they may be modified in some way, but preferably are still capable of Watson-Crick base pairing. Where appropriate the nucleic acids will be provided in double stranded or single stranded form. The invention provides all of the specific nucleic acid sequences mentioned herein in single or double stranded form, and thus includes the complementary strand to any sequence which is disclosed. The invention provides a kit for carrying out any process of the invention, including detection of a chromosomal interaction relating to prognosis. Such a kit can include a specific binding agent capable of detecting the relevant chromosomal interaction, such as agents capable of detecting a ligated nucleic acid generated by processes of the invention. Preferred agents present in the kit include probes capable of hybridising to the ligated nucleic acid or primer pairs, for example as described herein, capable of amplifying the ligated nucleic acid in a PCR reaction. The invention provides a device that is capable of detecting the relevant chromosome interactions. The device preferably comprises any specific binding agents, probe or primer pair capable of detecting the chromosome interaction, such as any such agent, probe or primer pair described herein. Detection Process In one aspect quantitative detection of the ligated sequence which is relevant to a chromosome interaction is carried out using a probe which is detectable upon activation during a PCR reaction, wherein said ligated sequence comprises sequences from two chromosome regions that come together in an epigenetic chromosome interaction, wherein said process comprises contacting the ligated sequence with the probe during a PCR reaction, and detecting the extent of activation of the probe, and wherein said probe binds the ligation site. The process typically allows particular interactions to be detected in a MIQE compliant manner using a dual labelled fluorescent hydrolysis probe. The probe is generally labelled with a detectable label which has an inactive and active state, so that it is only detected when activated. The extent of activation will be related to the extent of template (ligation product) present in the PCR reaction. Detection may be carried out during all or some of the PCR, for example for at least 50% or 80% of the cycles of the PCR. The probe can comprise a fluorophore covalently attached to one end of the oligonucleotide, and a quencher attached to the other end of the nucleotide, so that the fluorescence of the fluorophore is quenched by the quencher. In one aspect the fluorophore is attached to the 5’end of the oligonucleotide, and the quencher is covalently attached to the 3’ end of the oligonucleotide. Fluorophores that can be used in the process of the invention include FAM, TET, JOE, Yakima Yellow, HEX, Cyanine3, ATTO 550, TAMRA, ROX, Texas Red, Cyanine 3.5, LC610, LC 640, ATTO 647N, Cyanine 5, Cyanine 5.5 and ATTO 680. Quenchers that can be used with the appropriate fluorophore include TAM, BHQ1, DAB, Eclip, BHQ2 and BBQ650, optionally wherein said fluorophore is selected from HEX, Texas Red and FAM. Preferred combinations of fluorophore and quencher include FAM with BHQ1 and Texas Red with BHQ2. Use of the Probe in a qPCR Assay Hydrolysis probes of the invention are typically temperature gradient optimised with concentration matched negative controls. Preferably single-step PCR reactions are optimized. More preferably a standard curve is calculated. An advantage of using a specific probe that binds across the junction of the ligated sequence is that specificity for the ligated sequence can be achieved without using a nested PCR approach. The processes described herein allow accurate and precise quantification of low copy number targets. The target ligated sequence can be purified, for example gel-purified, prior to temperature gradient optimization. The target ligated sequence can be sequenced. Preferably PCR reactions are performed using about 10ng, or 5 to 15 ng, or 10 to 20ng, or 10 to 50ng, or 10 to 200ng template DNA. Forward and reverse primers are designed such that one primer binds to the sequence of one of the chromosome regions represented in the ligated DNA sequence, and the other primer binds to other chromosome region represented in the ligated DNA sequence, for example, by being complementary to the sequence. Detection of the ligated nucleic acid may use any probe disclosed herein in any table. In one aspect a qPCR system is used which uses one or more probes as disclosed in Table 16, or homologues of such probes. Choice of Ligated DNA Target The invention includes selecting primers and a probe for use in a PCR process as defined herein comprising selecting primers based on their ability to bind and amplify the ligated sequence and selecting the probe sequence based properties of the target sequence to which it will bind, in particular the curvature of the target sequence. Probes are typically designed / chosen to bind to ligated sequences which are juxtaposed restriction fragments spanning the restriction site. In one aspect of the invention, the predicted curvature of possible ligated sequences relevant to a particular chromosome interaction is calculated, for example using a specific algorithm referenced herein. The curvature can be expressed as degrees per helical turn, e.g.10.5° per helical turn. Ligated sequences are selected for targeting where the ligated sequence has a curvature propensity peak score of at least 5° per helical turn, typically at least 10°, 15° or 20° per helical turn, for example 5° to 20° per helical turn. Preferably the curvature propensity score per helical turn is calculated for at least 20, 50, 100, 200 or 400 bases, such as for 20 to 400 bases upstream and / or downstream of the ligation site. Thus in one aspect the target sequence in the ligated product has any of these levels of curvature. Target sequences can also be chosen based on lowest thermodynamic structure free energy. Particular Aspects In one aspect only intrachromosomal interactions are typed / detected, and no extrachromosomal interactions (between different chromosomes) are typed / detected. In particular aspects certain chromosome interactions are not typed, for example any specific interaction mentioned herein (for example as defined by any probe or primer pair mentioned herein). In some aspects chromosome interactions are not typed in any of the genes relevant to chromosome interactions mentioned herein. The data provided herein shows that the markers are ‘disseminating’ ones able to differentiate cases and non-cases for the relevant disease situation, for example prognosis. Therefore when carrying out the invention the skilled person will be able to determine by detection of the interactions which subgroup the individual is in. Disclosure in Publications and Priority Applications The contents of all publications mentioned herein are incorporated by reference into the present specification and may be used to further define the features relevant to the invention. The contents of all priority applications are incorporated into the present specification and may be used to define the features relevant to the invention. Techniques Used to Identify the Specific Relevant Chromosome Interactions The EpiSwitch™ platform technology detects epigenetic regulatory signatures of regulatory changes between normal and abnormal conditions or a phenotype of interest at loci. The EpiSwitch™ platform identifies and monitors the fundamental epigenetic level of gene regulation associated with regulatory high order structures of human chromosomes also known as chromosome conformation signatures. Chromosome signatures are a distinct primary step in a cascade of gene deregulation. They are high order biomarkers with a unique set of advantages against biomarker platforms that utilize late epigenetic and gene expression biomarkers, such as DNA methylation and RNA profiling. EpiSwitch™ Array Assay The custom EpiSwitch™ array-screening platforms come in 4 densities of, 15K, 45K, 100K, and 250K unique chromosome conformations, each chimeric fragment is repeated on the arrays 4 times, making the effective densities 60K, 180K, 400K and 1 million respectively. Custom Designed EpiSwitch™ Arrays The 15K EpiSwitch™ array can screen the whole genome including around 300 loci interrogated with the EpiSwitch™ Biomarker discovery technology. The EpiSwitch™ array is built on the Agilent SurePrint G3 Custom CGH microarray platform; this technology offers 4 densities, 60K, 180K, 400K and 1 Million probes. The density per array is reduced to 15K, 45K, 100K and 250K as each EpiSwitch™ probe is presented as a quadruplicate, thus allowing for statistical evaluation of the reproducibility. The average number of potential EpiSwitch™ markers interrogated per genetic loci is 50, as such the numbers of loci that can be investigated are 300, 900, 2000, and 5000. EpiSwitch™ Custom Array Pipeline The EpiSwitch™ array is a dual colour system with one set of samples, after EpiSwitch™ library generation, labelled in Cy5 and the other of sample (controls) to be compared / analyzed labelled in Cy3. The arrays are scanned using the Agilent SureScan Scanner and the resultant features extracted using the Agilent Feature Extraction software. The data is then processed using the EpiSwitch™ array processing scripts in R. The arrays are processed using standard dual colour packages in Bioconductor in R: Limma*. The normalisation of the arrays is done using the normalisedWithinArrays function in Limma* and this is done to the on chip Agilent positive controls and EpiSwitch™ positive controls. The data is filtered based on the Agilent Flag calls, the Agilent control probes are removed and the technical replicate probes are averaged, in order for them to be analysed using Limma*. The probes are modelled based on their difference between the 2 scenarios being compared and then corrected by using False Discovery Rate. Probes with Coefficient of Variation (CV) <=30% that are <=-1.1 or =>1.1 and pass the p<=0.1 FDR p-value are used for further screening. To reduce the probe set further Multiple Factor Analysis is performed using the FactorMineR package in R. * Note: LIMMA is Linear Models and Empirical Bayes Processes for Assessing Differential Expression in Microarray Experiments. Limma is an R package for the analysis of gene expression data arising from microarray or RNA-Seq. The pool of probes is initially selected based on adjusted p-value, FC and CV <30% (arbitrary cut off point) parameters for final picking. Further analyses and the final list are drawn based only on the first two parameters (adj. p-value; FC). Statistical Pipeline EpiSwitch™ screening arrays are processed using the EpiSwitch™ Analytical Package in R in order to select high value EpiSwitch™ markers for translation on to the EpiSwitch™ PCR platform. Step 1 Probes are selected based on their corrected p-value (False Discovery Rate, FDR), which is the product of a modified linear regression model. Probes below p-value <= 0.1 are selected and then further reduced by their Epigenetic ratio (ER), probes ER have to be <=-1.1 or =>1.1 in order to be selected for further analysis. The last filter is a coefficient of variation (CV), probes have to be below <=0.3. Step 2 The top 40 markers from the statistical lists are selected based on their ER for selection as markers for PCR translation. The top 20 markers with the highest negative ER load and the top 20 markers with the highest positive ER load form the list. Step 3 The resultant markers from step 1, the statistically significant probes form the bases of enrichment analysis using hypergeometric enrichment (HE). This analysis enables marker reduction from the significant probe list, and along with the markers from step 2 forms the list of probes translated on to the EpiSwitch™ PCR platform. The statistical probes are processed by HE to determine which genetic locations have an enrichment of statistically significant probes, indicating which genetic locations are hubs of epigenetic difference. The most significant enriched loci based on a corrected p-value are selected for probe list generation. Genetic locations below p-value of 0.3 or 0.2 are selected. The statistical probes mapping to these genetic locations, with the markers from step 2, form the high value markers for EpiSwitch™ PCR translation. Array design and processing Array Design Genetic loci are processed using the SII software (currently v3.2) to: - Pull out the sequence of the genome at these specific genetic loci (gene sequence with 50kb upstream and 20kb downstream) - Define the probability that a sequence within this region is involved in CCs - Cut the sequence using a specific RE - Determine which restriction fragments are likely to interact in a certain orientation - Rank the likelihood of different CCs interacting together. - Determine array size and therefore number of probe positions available (x) - Pull out x / 4 interactions. - For each interaction define sequence of 30bp to restriction site from part 1 and 30bp to restriction site of part 2. Check those regions are not repeats, if so exclude and take next interaction down on the list. Join both 30bp to define probe. - Create list of x / 4 probes plus defined control probes and replicate 4 times to create list to be created on array - Upload list of probes onto Agilent Sure design website for custom CGH array. - Use probe group to design Agilent custom CGH array. Array Processing - Process samples using EpiSwitch™ Standard Operating Procedure (SOP) for template production. - Clean up with ethanol precipitation by array processing laboratory. - Process samples as per Agilent SureTag complete DNA labelling kit - Agilent Oligonucleotide Array- based CGH for Genomic DNA Analysis Enzymatic labelling for Blood, Cells or Tissues - Scan using Agilent C Scanner using Agilent feature extraction software. EpiSwitchTMbiomarker signatures demonstrate high robustness, sensitivity and specificity in the stratification of complex disease phenotypes. This technology takes advantage of the latest breakthroughs in the science of epigenetics, monitoring and evaluation of chromosome conformation signatures as a highly informative class of epigenetic biomarkers. Current research methods deployed in academic environment require from 3 to 7 days for biochemical processing of cellular material in order to detect CCSs. Those procedures have limited sensitivity, and reproducibility; and furthermore, do not have the benefit of the targeted insight provided by the EpiSwitch™ Analytical Package at the design stage. EpiSwitch™ Array in silico marker identification CCS sites across the genome are directly evaluated by the EpiSwitch™ Array on clinical samples from testing cohorts for identification of all relevant stratifying lead biomarkers. The EpiSwitch™ Array platform is used for marker identification due to its high-throughput capacity, and its ability to screen large numbers of loci rapidly. The array used was the Agilent custom-CGH array, which allows markers identified through the in silico software to be interrogated. EpiSwitch™ PCR Potential markers identified by EpiSwitch™ Array are then validated either by EpiSwitch™ PCR or DNA sequencers (i.e. Roche 454, Nanopore MinION, etc.). The top PCR markers which are statistically significant and display the best reproducibility are selected for further reduction into the final EpiSwitch™ Signature Set, and validated on an independent cohort of samples. EpiSwitch™ PCR can be performed by a trained technician following a standardised operating procedure protocol established. All protocols and manufacture of reagents are performed under ISO 13485 and 9001 accreditation to ensure the quality of the work and the ability to transfer the protocols. EpiSwitch™ PCR and EpiSwitch™ Array biomarker platforms are compatible with analysis of both whole blood and cell lines. The tests are sensitive enough to detect abnormalities in very low copy numbers using small volumes of blood. Use of a Classifier The method of the invention may include analysis of the chromosome interactions identified in the individual, for example using a classifier, which may increase performance, such as sensitivity or specificity. The classifier is typically one that has been ‘trained’ on samples from the population and such training may assist the classifier to detect ageing or any aspect of ageing mentioned herein. The invention is illustrated by the following: Examples When looking at possible biological ‘clocks’ for predicting ageing, the following points are relevant: 1. It must predict the rate of aging. In other words, it would tell exactly where a person is in their total life span. It must be a better predictor of life span than chronological age. 2. It must monitor a basic process that underlies the aging process, not the effects of disease. 3. It must be able to be tested repeatedly without harming the person. For example, a blood test or an imaging technique. DNA methylation-derived epigenetic clocks are currently better at estimating actual chronological age than transcriptomic and proteomic data, or telomere length. DNA methylation clocks main differences are if they are intrinsic (intracellular) or extrinsic (across multiple tissues). The Horvath and PhenoAge clocks mentioned below are intrinsic, and the Horvath clock is extrinsic. Extrinsic DNA methylation clocks have been found to be more accurate at predicting time to death, although most tissues and organs from the same body are found to have broadly the same ages. Intrinsic measures seem to exhibit greater consistency across cell types and organs, but extrinsic measures seem to be more strongly associated with time to death. The following represent different approaches to biological clocks: 1. Horvath clock – This is based on methylation of CpG dinucleotides. Constructed across multiple tissues, including blood data as a potential “pan-tissue” master clock of chronological age, and focused on capturing shared changes, independent of tissue type. 2. PhenoAge – Also considers age-related bio-chemical measures such as age, albumin, creatine, glucose levels etc. Considers tobacco aging which other clocks did not. PhenoAge greatly outperforms the first generation of DNA methylation age estimators for predicting mortality, although all can lead to biased age estimations in children and in non-blood tissue. 3. GrimAge - Plasma protein level estimates by DNA methylation and incorporates pack-years smoking estimate. 4. Telomere Length - Numerous large-scale epidemiological studies have shown that telomere length has only a weak negative association with markers of biological age and life expectancy. 5. Mitotic age – estimation of the number of cell divisions. The different sets of CpGs that underpin the mitotic clock and the DNA methylation clock make it clear that these two clocks are distinct and that they measure different cellular properties. 6. epiTOC based on mitotic age – Captures cell-specific mitoses. Assesses increases in DNA methylation in the promoters of polycomb group targets that are initially unmethylated in foetal tissues. However there are clearly some challenges for DNA methylation clocks: - When applied to longitudinal datasets, these clocks show signs of an asymptote in later life, where chronological age increases at a faster rate than epigenetic estimated age. - The rate of change of DNA methylation age is faster during growth and development. - Cross-sectional studies have also consistently shown strong biological sex differences, with men having greater positive age acceleration than women. - In some cases, CpGs whose methylation increases with age are overrepresented near polycomb target genes. In the mouse, many clock CpGs localize to genes and promoters, and some studies also implicate hypomethylation of enhancers as a component of the mouse clock. - DNA methylation age progression reflects a general progression of high- and low-methylated CpGs to an intermediate level nearer 50% methylation. This suggests a smoothening with age of the landscape and a chronological clock driven by an increase in entropy. In the present work four groups of healthy individuals of mixed sex and ethnicity were collected to represent 4 age groups: 20-40, 40-60, 60-80, 80-100 (Table 17). We did not include into this study individuals below the age of 20, as those will still represent significant biological developmental processes associated with growth through adolescence into adulthood. Whole genome 3D profiles with EpiSwitch Explorer arrays were deployed to profile under 1 million chromosome conformations (CCSs) in bloods of all the individuals. Analysis of the data brought forward an unexpected result. Within this healthy population we discovered conditional chromosome conformations (CCSs) that showed significant and consistent change over time throughout all four groups – p value <0.001, Fold Change (-1.1<, or >1.1). Consistency of change over time weas assessed with clustering threshold analysis.150 CCSs increased in abundance over time, while 946 CCSs went down and / or disappeared over time (Figure 1). Quality Threshold (QT) Clustering revealed that 150 CCSs gradually increased in value across the four groups with increase of age, fitting into 5 distinct clusters based on Slope Coefficient. Cluster 3 showed the fastest change over time, with Slope Coefficient at 0.176 (Figure 2). The 150 CCSs increasing with age were mapped to their closest genes, affected by 3D architecture. On the basis of affected genes, the biological pathways and diseases enriched with controls by those genes were identified. This includes Peptide Hormone Metabolism and Nitric Oxide Stimulation pathways, as well as groups pf genes implicated in age-related diseases such as diabetes mellitus, prostate and breast cancers, hypertension, asthma, Alzheimer’s. [See tables 18 to 22] Identified cluster groups suggest synchronized progression of regulatory adjustment for pathways and genes captured in 3D genome architecture regulation. Thus, cluster one shows age related changes in sync for nitric oxide stimulatory pathway, oxytocin signalling, platelet homeostasis, mRNA decay and turnover, nicotine addiction. Cluster 2 – pathways for hormone metabolism, statin, blood- brain barrier. Clusters 3,4 and 5 – olfactory transduction, EGFR and IL-2, FOXA2 and FOXA3 Transcription Networks, regulation of Gap Junction activity. The gene-based Kyoto Encyclopaedia of Genes and Genomes (KEGG) Pathways Database show existing understanding of Longevity Regulating Pathway, based on gene function and their expression regulation in tissue. In this case, processed 3D genomic profiles measured as systemic increasing signatures in blood, offer processed EpiSwitch biomarkers representing regulatory contribution by 3D genome architecture as systemic reflection of genome regulation – namely over INS, Ras and CREB loci of the established KEGG Longevity Pathway network. The regulation of longevity is dependent on genetic and environmental factors. Caloric restriction (CR), which in other words is limiting the nutritional intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan. The loci members for CCSs from clusters 3,4 and 5 are found in the Longevity Regulating pathway and are as follows: INS, Ras and CREB. The Longevity regulating pathway has loci members for CCSs from cluster 2 for Age down, these include the following: INS, PI3K, 4E-BP and G9a. Four pathways have been implicated in mediating the CR effect. These are the insulin like growth factor (IGF-1) / insulin signaling pathway, the sirtuin pathway, the adenosine monophosphate (AMP) activated protein kinase (AMPK) pathway and the target of rapamycin (TOR) pathway. The collective response of these pathways to CR is believed to promote cellular fitness and ultimately longevity via activation of autophagy, stress defense mechanisms, and survival pathways while attenuating proinflammatory mediators and cellular growth. Furthermore, there is evidence supporting that life span extension can be achieved with pharmacologic agents that mimic the effects of caloric restriction, such as rapamycin, via mTOR signaling blockade, resveratrol, by activating SIRT1 activity, and metformin, which seems to be a robust stimulator of AMPK activity. As an aging suppressor, Klotho is an important molecule in aging processes and its overexpression results in longevity. The majority of the significant CCSs consistently changing with time are the 946 CCS which decrease with age, forming 10 distinct clusters with different Slope Coefficients (Figure 3). Cluster 5 shows the biggest change with Slope Coefficient = -0.21 (Figures 4 and 5). The super-pathway affected by identified EpiSwitch markers is Cytokine Signalling in Immune System. This pathway contains 760 mapped genes, and 70 genes are affected by present changes in 3D genome architecture.3D genomic architecture changes with time map to the NAD Metabolism pathway (NNT, NRK and ACMSD loci affected by genome architecture changes); Autophagy pathway (RAB3D, IL15, RAB23, MAPK9); Interferon Gamma Signalling (GBP2, KPNA3, GBP4, GBP7, SEH1L). In cluster 7, the second fastest decline with time, changes in genome architecture map to mTOR Signalling Pathway – at the loci LPIN1, FZD1, FLT4, MAPK1; HIF Repressors pathway – at the loci CITED2, MAPK1; TNFR1 Pathway at the loci ACTA2, NGFR, FAS, PTPRA, NSMAF, MAPK1. [See tables 23 to 25] The mitogen-activated protein kinase (MAPK) cascade is a vastly conserved component that is involved in numerous cellular functions, one of wish is cell proliferation, differentiation and migration. The loci members from CCSs that decrease with age are as follows: CACN, RasGRP, CNrasGEF, PKA, ERK, PTP, MKP, cPLA2, NFkB, GF, RTK, CRKII, HSP72, NFAT-2, JNK, Cdc43Rad, PTP, MKP, TRAF2, IRAK1 / 4, PP2CB, MAPKAPK. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1 / 2, Jun amino-terminal kinases (JNK1 / 2 / 3), p38 proteins (p38alpha / beta / gamma / delta) and ERK5, that are activated by specific MAPKKs: MEK1 / 2 for ERK1 / 2, MKK3 / 6 for the p38, MKK4 / 7 (JNKK1 / 2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1 / 2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1 / 2 in response to pro-inflammatory stimuli. Necroptosis is programmed form of necrosis. It can be started by different stimuli, some of which are tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in pathogenesis of many diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections. The loci members for CCSs that decrease over age are as follows: TRAF2 / 5, LUBAC, CYLD, CaMKII, Fas, IFNR, JAKs, STAT, Hsp90, A20, PYGL, JNK, Hsp90, cPLA2, H2AX, ESCRT-III. Phagocytosis plays an essential role in host-defence mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodelling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes. The pathway has loci members for CCSs that decrease over age are as follows: FcyRIIB, FcyRIIIA, PI3K, ERK1 / 2, cPLA2, CrkII, Rac, Cofilin. The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine / threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival. The mTOR signalling pathway has loci members for CCSs in cluster 7 which show the 2nd biggest decrease over age and are as follows: Frizzled, ERK1 / 2 and Lipin-1. EpiSwitch CCSs capture major changes in processes central to the mechanisms of ageing, these include the following: TNFR1 pathway, Necroptosis / Necrosis, Apoptosis, Oxidative Stress, HIF1 Pathway, Autophagy, mTORC1, NAD / NADH and ATP depletion. Listed loci demonstrate that processed systemic conditional chromosome conformations with the defined consistent trend of increase or decrease over time, not only show statistical features associated with age as a parameter, but also by their localization over genome demonstrate consistency with gene-centric view over age-related regulation. It is important to emphasize, that EpiSwitch biomarkers were developed and selected from across the whole genome, both coding and non-coding parts of it, in a non-biased way, without any modelling on the basis of known age-related genes and pathways for any selection. Statistical significance was found throughout age groups from 20 to 100 years. Following statistical data of cluster analysis over 4 age groups, identified CCs show relevance by their loci positions across the genes with functions linked to age. The concept that systemic blood-based readout of an individual will reflect such corner stones of ageing regulation as apoptosis, autophagy, mTOR, senescence vs growth, NAD and ATP depletion, HIF1 and TNFR1 (table 26). For the Kyoto Encyclopaedia of Genes and Genomes (KEGG) Pathways Database MAPK Pathway, Necroptosis Pathway, Gc GammaR Pathway, mTOR signalling Pathway, show significant presence of genes implicated in diminishing presence of regulatory conditional CCSs with age. Longevity Regulating Pathway, based on gene function and their expression regulation in tissue, the processed 3D genomic profiles measured as systemic decreasing signatures in blood, offer processed EpiSwitch biomarkers representing regulatory contribution by 3D genome architecture as systemic reflection of genome regulation – namely over INS, PI3K, G9a, 4E-BP loci of the established KEGG Longevity Pathway network. All together, the identified CCSs capture major processes central to ageing mechanisms Table 19 has a list of diseases, whose pathways and gene loci are enriched with top 150 CCS markers that accumulate with age. In broad terms those are hypertension, neurodegenerative and cognitive conditions, diabetes type 2. According to the table out of 574 genetic loci associated with type 2 diabetes, 19 are the ones that with age will be changing at certain rate and could with time acquire profiles associated with the disease. Type 2 diabetes is considered an epigenetic disease, which normally develops under environmental circumstances with time, often later in life. Other diseases that could show with ageing profiles overlap with disease footprint are prostate cancer, breast cancer, colorectal cancer, retinitis pigmentosa, hypertension, Alzheimer’s, neuroblastoma, asthma, pancreatic adenocarcinoma, cardiomyopathy, colorectal adenoma, ovarian cancer, chromic leukaemia. All these indications have come up through analysis from non-biased whole genome 3D architecture analysis and its changes with time. In all these cases prophylactics and early diagnosis could be recommended on the basis of the measure of the extent of the individual ageing profile. The chromosome interaction markers from each of the clusters will provide molecular readouts of the extent of progression along the ‘ageing changes’ spectrum, typically with a direct relevance to overlap into footprints of diseases and co-morbidities. There will be, for example, a clear measure of the developing overlap with rheumatoid arthritis, and not hypertension, or type 3 diabetes. This would help define early prophylactic measures (natural anti-inflammatories, prophylactic treatment with abatacept, etc.) and changes in life-style beneficial for the particular individual. Conclusion This work shows discovery of clusters of 3D genome architecture manifested through specific architecture chromosome conformations, that increase or decrease their abundance in blood of individuals with age. These clusters define 3D genomic regulation over specific groups of biological pathways, genes and controls which appear synchronized at the rate of their changes. Each cluster profile acts as reference point for an assessment of biological ageing in an individual, defined within the group of pathways and genes it includes. Altogether, an individual could be profiled by 3D genomics across the whole genome. The abundance of individual chromosome conformations could be compared to the profiles across age groups, cluster by cluster. This will define in each group of biological clusters, the biological age against the average signal distribution. In one aspect, within the remit of healthy ageing, without resorting to the disease diagnosis, one can evaluate progression for each of the clusters through the natural trend of signal increase or decrease. Each cluster represents biomarkers that change throughout the age at the same rate, representing changes in specific regulatory networks and selective regulatory pathways. Different clusters are associated with different rates of change and different networks and pathways, i.e. cluster 1 captures age-related changes with nitric oxide and oxytocin pathways (table 20, cluster 2 with age- related redox homeostasis (table 21), clusters 3, 4 and 5 (table 22) with cellular chronological longevity, etc. Because of the clear separation into clusters, these changes proceed at different rate with a certain independence. Using markers from each cluster addresses the evaluation of molecular and cellular ageing in relation only to the pathways represented in that cluster. Thus, an individual might show advanced ageing on the front of much reduced vascular muscle tone by cluster 1, but still robust controls over chronological life span and healthy cellular quiescence corresponding to much younger average (cellular chronological longevity). In that sense each cluster is responsible at the molecular regulatory level for separate defined groups of pathways that could advance into ageing prematurely compared to the other clusters, when evaluated against the established average. The chromosome interaction markers are therefore “pharmaco-dynamic” markers for those distinct parallel processes associated with age-related changes. Table 1(a) probe T1 T2 1 Hg38_1_112725422_112728579_112766364_112768833_RR 7.39417752 7.56208759 2 Hg38_1_112725422_112728579_112766364_112768833_RR 7.39417752 7.56208759 3 Hg38_1_112725422_112728579_112766364_112768833_RR 7.39417752 7.56208759 4 Hg38_1_229415974_229429565_229495519_229498185_RF 7.59233783 7.69125559 5 Hg38_1_229415974_229429565_229495519_229498185_RF 7.59233783 7.69125559 6 Hg38_1_229415974_229429565_229495519_229498185_RF 7.59233783 7.69125559 7 Hg38_1_229415974_229429565_229597562_229600939_RF 7.63274191 7.74857645 8 Hg38_1_229415974_229429565_229597562_229600939_RF 7.63274191 7.74857645 9 Hg38_1_229415974_229429565_229597562_229600939_RF 7.63274191 7.74857645 10 Hg38_1_229415974_229429565_229597562_229600939_RF 7.63274191 7.74857645 11 Hg38_1_63375818_63382270_63565766_63573040_RR 7.69234265 7.94994326 12 Hg38_1_63375818_63382270_63565766_63573040_RR 7.69234265 7.94994326 13 Hg38_1_63375818_63382270_63565766_63573040_RR 7.69234265 7.94994326 14 Hg38_1_63509990_63518130_63565766_63573040_FR 7.76103107 7.90447228 15 Hg38_1_63509990_63518130_63565766_63573040_FR 7.76103107 7.90447228 16 Hg38_1_63509990_63518130_63565766_63573040_FR 7.76103107 7.90447228 17 Hg38_10_110255334_110262449_110372591_110379002_FF 7.41143588 7.58924183 18 Hg38_10_110255334_110262449_110372591_110379002_FF 7.41143588 7.58924183 19 Hg38_10_110255334_110262449_110372591_110379002_FF 7.41143588 7.58924183 20 Hg38_10_14669406_14680371_14745587_14751442_RR 8.01923801 8.16082989 21 Hg38_10_14669406_14680371_14745587_14751442_RR 8.01923801 8.16082989 22 Hg38_10_14669406_14680371_14745587_14751442_RR 8.01923801 8.16082989 23 Hg38_10_51146653_51155733_51262107_51264325_FF 7.99980736 8.22317673 24 Hg38_10_51146653_51155733_51262107_51264325_FF 7.99980736 8.22317673 25 Hg38_10_51146653_51155733_51262107_51264325_FF 7.99980736 8.22317673 26 Hg38_11_1593813_1599136_1656768_1658167_FR 7.29133441 7.60773014 27 Hg38_11_1593813_1599136_1656768_1658167_FR 7.29133441 7.60773014 28 Hg38_11_1593813_1599136_1656768_1658167_FR 7.29133441 7.60773014 29 Hg38_11_1593813_1599136_1656768_1658167_FR 7.29133441 7.60773014 30 Hg38_12_20741647_20746439_20768546_20775250_FR 7.77193598 7.9620119 31 Hg38_12_20741647_20746439_20768546_20775250_FR 7.77193598 7.9620119 32 Hg38_12_20741647_20746439_20768546_20775250_FR 7.77193598 7.9620119 33 Hg38_12_62927354_62932854_63128592_63132984_RR 7.5718421 7.74846065 34 Hg38_12_62927354_62932854_63128592_63132984_RR 7.5718421 7.74846065 35 Hg38_12_62927354_62932854_63128592_63132984_RR 7.5718421 7.74846065 36 Hg38_12_85891337_85899726_85925517_85935710_RR 7.19265144 7.36405044 37 Hg38_12_85891337_85899726_85925517_85935710_RR 7.19265144 7.36405044 38 Hg38_12_85891337_85899726_85925517_85935710_RR 7.19265144 7.36405044 39 Hg38_12_85901338_85909428_85925517_85935710_FR 7.65204095 7.78968187 40 Hg38_12_85901338_85909428_85925517_85935710_FR 7.65204095 7.78968187 41 Hg38_12_85901338_85909428_85925517_85935710_FR 7.65204095 7.78968187 42 Hg38_13_37139027_37146823_37172447_37177058_RR 8.03465247 8.27877114 Hg38_13_37139027_37146823_37172447_37177058_RR 8.03465247 8.27877114 Hg38_13_37139027_37146823_37172447_37177058_RR 8.03465247 8.27877114 Hg38_13_37787963_37794369_37847106_37854730_RR 7.9620815 8.09920168 Hg38_13_37787963_37794369_37847106_37854730_RR 7.9620815 8.09920168 Hg38_13_37787963_37794369_37847106_37854730_RR 7.9620815 8.09920168 Hg38_13_72447916_72456453_72559509_72566807_RF 7.61280177 7.76686281 Hg38_13_72447916_72456453_72559509_72566807_RF 7.61280177 7.76686281 Hg38_13_72447916_72456453_72559509_72566807_RF 7.61280177 7.76686281 Hg38_13_84548737_84558296_84732514_84743776_RF 7.39604243 7.42332514 Hg38_13_84548737_84558296_84732514_84743776_RF 7.39604243 7.42332514 Hg38_13_84548737_84558296_84732514_84743776_RF 7.39604243 7.42332514 Hg38_13_84569455_84579978_84732514_84743776_RF 7.48007737 7.52978854 Hg38_13_84569455_84579978_84732514_84743776_RF 7.48007737 7.52978854 Hg38_13_84569455_84579978_84732514_84743776_RF 7.48007737 7.52978854 Hg38_14_106533738_106542151_106772265_106777775_FF 7.53452069 7.60959222 Hg38_14_106533738_106542151_106772265_106777775_FF 7.53452069 7.60959222 Hg38_14_106533738_106542151_106772265_106777775_FF 7.53452069 7.60959222 Hg38_14_23629517_23632644_23796221_23801904_FF 8.00532694 8.21632556 Hg38_14_23629517_23632644_23796221_23801904_FF 8.00532694 8.21632556 Hg38_14_23629517_23632644_23796221_23801904_FF 8.00532694 8.21632556 Hg38_14_41503301_41508857_41520350_41525995_RR 7.63181653 7.71080001 Hg38_14_41503301_41508857_41520350_41525995_RR 7.63181653 7.71080001 Hg38_14_41503301_41508857_41520350_41525995_RR 7.63181653 7.71080001 Hg38_14_95537151_95538979_95608869_95613346_RF 7.2908612 7.42976989 Hg38_14_95537151_95538979_95608869_95613346_RF 7.2908612 7.42976989 Hg38_14_95537151_95538979_95608869_95613346_RF 7.2908612 7.42976989 Hg38_14_95608869_95613346_95643450_95648295_FF 7.18507236 7.28543929 Hg38_14_95608869_95613346_95643450_95648295_FF 7.18507236 7.28543929 Hg38_14_95608869_95613346_95643450_95648295_FF 7.18507236 7.28543929 Hg38_17_32729890_32740232_32890505_32898320_FR 7.23703936 7.37121518 Hg38_17_32729890_32740232_32890505_32898320_FR 7.23703936 7.37121518 Hg38_17_32729890_32740232_32890505_32898320_FR 7.23703936 7.37121518 Hg38_2_148241618_148249069_148260100_148261975_FF 7.38271091 7.51328077 Hg38_2_148241618_148249069_148260100_148261975_FF 7.38271091 7.51328077 Hg38_2_148241618_148249069_148260100_148261975_FF 7.38271091 7.51328077 Hg38_2_161437159_161441836_161507794_161513168_FF 7.50184249 7.72054047 Hg38_2_161437159_161441836_161507794_161513168_FF 7.50184249 7.72054047 Hg38_2_161437159_161441836_161507794_161513168_FF 7.50184249 7.72054047 Hg38_2_177462861_177470270_177742494_177747277_RF 7.80759886 7.96704715 Hg38_2_177462861_177470270_177742494_177747277_RF 7.80759886 7.96704715 Hg38_2_177462861_177470270_177742494_177747277_RF 7.80759886 7.96704715 Hg38_2_177462861_177470270_177742494_177747277_RF 7.80759886 7.96704715 Hg38_2_177628143_177634097_177742494_177747277_RF 7.39469455 7.67424162 Hg38_2_177628143_177634097_177742494_177747277_RF 7.39469455 7.67424162 Hg38_2_177628143_177634097_177742494_177747277_RF 7.39469455 7.67424162 Hg38_2_197269449_197272090_197498475_197505285_RR 7.2806334 7.39341627 Hg38_2_197269449_197272090_197498475_197505285_RR 7.2806334 7.39341627 Hg38_2_197269449_197272090_197498475_197505285_RR 7.2806334 7.39341627 Hg38_2_197269449_197272090_197498475_197505285_RR 7.2806334 7.39341627 Hg38_2_197269449_197272090_197498475_197505285_RR 7.2806334 7.39341627 Hg38_2_197269449_197272090_197498475_197505285_RR 7.2806334 7.39341627 Hg38_2_238186073_238189114_238212400_238218048_RF 7.67631489 7.81927625 Hg38_2_238186073_238189114_238212400_238218048_RF 7.67631489 7.81927625 Hg38_2_238186073_238189114_238212400_238218048_RF 7.67631489 7.81927625 Hg38_2_31033925_31042366_31085435_31089206_RF 7.55304063 7.83665294 Hg38_2_31033925_31042366_31085435_31089206_RF 7.55304063 7.83665294 Hg38_2_31033925_31042366_31085435_31089206_RF 7.55304063 7.83665294 Hg38_2_31085435_31089206_31172588_31186669_FF 7.36364621 7.63533035 Hg38_2_31085435_31089206_31172588_31186669_FF 7.36364621 7.63533035 Hg38_2_31085435_31089206_31172588_31186669_FF 7.36364621 7.63533035 Hg38_2_31085435_31089206_31312508_31323292_FF 7.02821517 7.30096569 Hg38_2_31085435_31089206_31312508_31323292_FF 7.02821517 7.30096569 Hg38_2_31085435_31089206_31312508_31323292_FF 7.02821517 7.30096569 Hg38_2_67151687_67159275_67332990_67339036_RR 7.67293757 7.78304 Hg38_2_67151687_67159275_67332990_67339036_RR 7.67293757 7.78304 Hg38_2_67151687_67159275_67332990_67339036_RR 7.67293757 7.78304 Hg38_2_77768060_77779949_77966521_77969297_FR 7.7383759 7.77989436 Hg38_2_77768060_77779949_77966521_77969297_FR 7.7383759 7.77989436 Hg38_2_77768060_77779949_77966521_77969297_FR 7.7383759 7.77989436 Hg38_22_23537073_23543369_23665784_23673822_FR 7.64407792 7.84399411 Hg38_22_23537073_23543369_23665784_23673822_FR 7.64407792 7.84399411 Hg38_22_23537073_23543369_23665784_23673822_FR 7.64407792 7.84399411 Hg38_22_47483522_47488731_47501191_47514798_RF 7.96525354 8.19208372 Hg38_22_47483522_47488731_47501191_47514798_RF 7.96525354 8.19208372 Hg38_22_47483522_47488731_47501191_47514798_RF 7.96525354 8.19208372 Hg38_3_20266298_20272147_20349178_20352408_FR 7.20976338 7.35992101 Hg38_3_20266298_20272147_20349178_20352408_FR 7.20976338 7.35992101 Hg38_3_20266298_20272147_20349178_20352408_FR 7.20976338 7.35992101 Hg38_3_4781098_4785952_4919859_4925851_RR 8.0589908 8.19076408 Hg38_3_4781098_4785952_4919859_4925851_RR 8.0589908 8.19076408 Hg38_3_4781098_4785952_4919859_4925851_RR 8.0589908 8.19076408 Hg38_4_15775018_15780638_15963574_15967289_RF 7.69938533 7.86971678 Hg38_4_15775018_15780638_15963574_15967289_RF 7.69938533 7.86971678 Hg38_4_15775018_15780638_15963574_15967289_RF 7.69938533 7.86971678 Hg38_4_15775018_15780638_15963574_15967289_RF 7.69938533 7.86971678 Hg38_4_15825519_15835011_15963574_15967289_RF 7.59641433 7.74109307 Hg38_4_15825519_15835011_15963574_15967289_RF 7.59641433 7.74109307 Hg38_4_15825519_15835011_15963574_15967289_RF 7.59641433 7.74109307 Hg38_4_15825519_15835011_15963574_15967289_RF 7.59641433 7.74109307 Hg38_4_15857451_15860417_15963574_15967289_RF 7.80334826 8.02519453 Hg38_4_15857451_15860417_15963574_15967289_RF 7.80334826 8.02519453 Hg38_4_15857451_15860417_15963574_15967289_RF 7.80334826 8.02519453 Hg38_4_15897457_15905803_15963574_15967289_RF 7.70383087 7.84859015 Hg38_4_15897457_15905803_15963574_15967289_RF 7.70383087 7.84859015 Hg38_4_15897457_15905803_15963574_15967289_RF 7.70383087 7.84859015 Hg38_4_15917707_15927576_15963574_15967289_RF 7.77662006 7.93527881 Hg38_4_15917707_15927576_15963574_15967289_RF 7.77662006 7.93527881 Hg38_4_15917707_15927576_15963574_15967289_RF 7.77662006 7.93527881 Hg38_4_15937449_15943139_15963574_15967289_RF 7.59753439 7.65647966 Hg38_4_15937449_15943139_15963574_15967289_RF 7.59753439 7.65647966 Hg38_4_15937449_15943139_15963574_15967289_RF 7.59753439 7.65647966 Hg38_4_15963574_15967289_16069234_16073831_FR 7.68505479 7.78360485 Hg38_4_15963574_15967289_16069234_16073831_FR 7.68505479 7.78360485 Hg38_4_15963574_15967289_16069234_16073831_FR 7.68505479 7.78360485 Hg38_4_15963574_15967289_16074044_16080316_FR 7.67668424 7.8542416 Hg38_4_15963574_15967289_16074044_16080316_FR 7.67668424 7.8542416 Hg38_4_15963574_15967289_16074044_16080316_FR 7.67668424 7.8542416 Hg38_4_15963574_15967289_16080316_16087433_FF 7.73460723 7.87798311 Hg38_4_15963574_15967289_16080316_16087433_FF 7.73460723 7.87798311 Hg38_4_15963574_15967289_16080316_16087433_FF 7.73460723 7.87798311 Hg38_4_15963574_15967289_16092319_16097311_FF 7.89805718 8.0396109 Hg38_4_15963574_15967289_16092319_16097311_FF 7.89805718 8.0396109 Hg38_4_15963574_15967289_16092319_16097311_FF 7.89805718 8.0396109 Hg38_4_15963574_15967289_16092319_16097311_FR 7.95513135 8.07374357 Hg38_4_15963574_15967289_16092319_16097311_FR 7.95513135 8.07374357 Hg38_4_15963574_15967289_16092319_16097311_FR 7.95513135 8.07374357 Hg38_4_15963574_15967289_16185308_16191596_FR 7.72747125 7.92109202 Hg38_4_15963574_15967289_16185308_16191596_FR 7.72747125 7.92109202 Hg38_4_15963574_15967289_16185308_16191596_FR 7.72747125 7.92109202 Hg38_4_49523277_49526604_49557758_49568290_RR 7.83288567 8.00599477 Hg38_4_49523277_49526604_49557758_49568290_RR 7.83288567 8.00599477 Hg38_4_49523277_49526604_49557758_49568290_RR 7.83288567 8.00599477 Hg38_5_170562897_170568097_170763313_170768494_FR 7.38566776 7.57188853 Hg38_5_170562897_170568097_170763313_170768494_FR 7.38566776 7.57188853 Hg38_5_170562897_170568097_170763313_170768494_FR 7.38566776 7.57188853 Hg38_5_18035857_18044300_18262451_18265657_FR 7.93110776 7.9900557 Hg38_5_18035857_18044300_18262451_18265657_FR 7.93110776 7.9900557 Hg38_5_18035857_18044300_18262451_18265657_FR 7.93110776 7.9900557 Hg38_7_17183778_17190301_17370716_17375896_FF 7.9520072 8.18484657 Hg38_7_17183778_17190301_17370716_17375896_FF 7.9520072 8.18484657 Hg38_7_17183778_17190301_17370716_17375896_FF 7.9520072 8.18484657 Hg38_7_24023518_24030634_24291036_24296652_FR 7.92548357 8.05696538 175 Hg38_7_24023518_24030634_24291036_24296652_FR 7.92548357 8.05696538 176 Hg38_7_24023518_24030634_24291036_24296652_FR 7.92548357 8.05696538 177 Hg38_8_57890256_57891804_57932651_57941963_FF 7.95000578 8.1743426 178 Hg38_8_57890256_57891804_57932651_57941963_FF 7.95000578 8.1743426 179 Hg38_8_57890256_57891804_57932651_57941963_FF 7.95000578 8.1743426 180 Hg38_8_58289702_58295345_58443139_58446364_RF 7.93411544 8.12725536 181 Hg38_8_58289702_58295345_58443139_58446364_RF 7.93411544 8.12725536 182 Hg38_8_58289702_58295345_58443139_58446364_RF 7.93411544 8.12725536 183 Hg38_9_101409353_101421725_101535769_101539902_RF 7.89117103 8.19535222 184 Hg38_9_101409353_101421725_101535769_101539902_RF 7.89117103 8.19535222 185 Hg38_9_101409353_101421725_101535769_101539902_RF 7.89117103 8.19535222 186 Hg38_9_101409353_101421725_101535769_101539902_RF 7.89117103 8.19535222 187 Hg38_9_101535769_101539902_101660909_101670626_FF 7.8760781 8.0761842 188 Hg38_9_101535769_101539902_101660909_101670626_FF 7.8760781 8.0761842 189 Hg38_9_101535769_101539902_101660909_101670626_FF 7.8760781 8.0761842 190 Hg38_X_26183933_26198528_26208984_26213220_FF 7.88861285 8.15432169 191 Hg38_X_26183933_26198528_26208984_26213220_FF 7.88861285 8.15432169 192 Hg38_X_26183933_26198528_26208984_26213220_FF 7.88861285 8.15432169 193 Hg38_X_31047661_31051693_31072937_31079985_FF 7.80412759 7.99206335 194 Hg38_X_31047661_31051693_31072937_31079985_FF 7.80412759 7.99206335 195 Hg38_X_31047661_31051693_31072937_31079985_FF 7.80412759 7.99206335 196 Hg38_X_75983372_75987093_76175352_76179997_FF 7.35481504 7.55757719 197 Hg38_X_75983372_75987093_76175352_76179997_FF 7.35481504 7.55757719 198 Hg38_X_75983372_75987093_76175352_76179997_FF 7.35481504 7.55757719 199 Hg38_X_76009002_76018914_76175352_76179997_FF 7.48817823 7.65421502 200 Hg38_X_76009002_76018914_76175352_76179997_FF 7.48817823 7.65421502 201 Hg38_X_76009002_76018914_76175352_76179997_FF 7.48817823 7.65421502 Table 1(b) T3 T4 P.value adj.P.Val FC gene distance 7.65914156 8.02453033 0.00052535 0.03112245 1.14775223 RP11- 13990 426L16.10 7.65914156 8.02453033 0.00052535 0.03112245 1.14775223 PPM1J 9946 7.65914156 8.02453033 0.00052535 0.03112245 1.14775223 FAM19A3 0 7.80677538 8.13742661 0.00098246 0.03543933 1.12902592 NUP133 0 7.80677538 8.13742661 0.00098246 0.03543933 1.12902592 ACTA1 0 7.80677538 8.13742661 0.00098246 0.03543933 1.12902592 ABCB10 18398 7.87755939 8.21468033 0.00059872 0.03221946 1.13877271 NUP133 0 7.87755939 8.21468033 0.00059872 0.03221946 1.13877271 ACTA1 0 7.87755939 8.21468033 0.00059872 0.03221946 1.13877271 TAF5L 0 7.87755939 8.21468033 0.00059872 0.03221946 1.13877271 ABCB10 0 7.96378362 8.22446618 0.00097095 0.0354188 1.1180782 ITGB3BP 0 7.96378362 8.22446618 0.00097095 0.0354188 1.1180782 EFCAB7 0 7.96378362 8.22446618 0.00097095 0.0354188 1.1180782 ALG6 0 7.97355302 8.25510446 0.00072029 0.03351912 1.11352202 PGM1 20237 7.97355302 8.25510446 0.00072029 0.03351912 1.11352202 EFCAB7 0 7.97355302 8.25510446 0.00072029 0.03351912 1.11352202 ITGB3BP 0 7.66420526 7.94052618 0.00036194 0.0291779 1.12211725 SMNDC1 0 7.66420526 7.94052618 0.00036194 0.0291779 1.12211725 MXI1 0 7.66420526 7.94052618 0.00036194 0.0291779 1.12211725 DUSP5 118837 8.22386398 8.49826132 0.00081359 0.03394661 1.10957747 HSPA14 86723 8.22386398 8.49826132 0.00081359 0.03394661 1.10957747 FAM107B 0 8.22386398 8.49826132 0.00081359 0.03394661 1.10957747 CDNF 67809 8.35506097 8.58381814 4.7074E-05 0.02750392 1.13949268 ASAH2B 330159 8.35506097 8.58381814 4.7074E-05 0.02750392 1.13949268 PRKG1 0 8.35506097 8.58381814 4.7074E-05 0.02750392 1.13949268 A1CF 260979 7.84946497 7.93529629 0.00026222 0.02831289 1.16260583 KRTAP5-5 0 7.84946497 7.93529629 0.00026222 0.02831289 1.16260583 KRTAP5-2 0 7.84946497 7.93529629 0.00026222 0.02831289 1.16260583 KRTAP5-4 0 7.84946497 7.93529629 0.00026222 0.02831289 1.16260583 KRTAP5-3 0 8.04421482 8.26244082 0.0002032 0.02750392 1.11370856 SLCO1B3 35453 8.04421482 8.26244082 0.0002032 0.02750392 1.11370856 SLCO1C1 0 8.04421482 8.26244082 0.0002032 0.02750392 1.11370856 RP11- 40425 545J16.1 7.96068428 8.15217145 2.0877E-05 0.02750392 1.14497902 AVPR1A 9776 7.96068428 8.15217145 2.0877E-05 0.02750392 1.14497902 MON2 326876 7.96068428 8.15217145 2.0877E-05 0.02750392 1.14497902 PPM1H 0 7.52333496 7.65976314 7.2601E-05 0.02750392 1.1142415 NTS 8346 7.52333496 7.65976314 7.2601E-05 0.02750392 1.1142415 RASSF9 54768 7.52333496 7.65976314 7.2601E-05 0.02750392 1.1142415 MGAT4C 19957 7.87447697 8.10687837 0.00039036 0.0291779 1.10567757 NTS 18347 7.87447697 8.10687837 0.00039036 0.0291779 1.10567757 RASSF9 64769 7.87447697 8.10687837 0.00039036 0.0291779 1.10567757 MGAT4C 19957 8.30081873 8.62318152 0.000863 0.03455929 1.13191331 SUPT20H 79315 8.30081873 8.62318152 0.000863 0.03455929 1.13191331 AL138706.2 118256 8.30081873 8.62318152 0.000863 0.03455929 1.13191331 CSNK1A1L 33364 8.30139332 8.5707012 6.927E-05 0.02750392 1.15093397 UFM1 495120 8.30139332 8.5707012 6.927E-05 0.02750392 1.15093397 TRPC4 0 8.30139332 8.5707012 6.927E-05 0.02750392 1.15093397 POSTN 189120 7.87970465 8.13128513 0.0001761 0.02750392 1.12258851 BORA 160943 7.87970465 8.13128513 0.0001761 0.02750392 1.12258851 MZT1 141551 7.87970465 8.13128513 0.0001761 0.02750392 1.12258851 DIS3 185363 7.77464353 7.99249264 0.00056056 0.0315481 1.15995345 SLITRK1 666345 7.77464353 7.99249264 0.00056056 0.0315481 1.15995345 SLITRK6 1049015 7.77464353 7.99249264 0.00056056 0.0315481 1.15995345 SLITRK5 2928840 7.77765988 7.95669563 0.00039467 0.0291779 1.12332284 SLITRK1 687063 7.77765988 7.95669563 0.00039467 0.0291779 1.12332284 SLITRK5 2928840 7.77765988 7.95669563 0.00039467 0.0291779 1.12332284 SLITRK6 1049015 7.93286973 8.1183402 0.00021204 0.02750392 1.15466441 CRIP1 1041472 7.93286973 8.1183402 0.00021204 0.02750392 1.15466441 C14orf80 1034164 7.93286973 8.1183402 0.00021204 0.02750392 1.15466441 TMEM121 1003537 8.43798317 8.48821504 0.00043273 0.02993972 1.12274647 AP1G2 61448 8.43798317 8.48821504 0.00043273 0.02993972 1.12274647 JPH4 50718 8.43798317 8.48821504 0.00043273 0.02993972 1.12274647 DHRS2 0 7.83374031 8.12273912 0.00097862 0.03543933 1.1169548 LRFN5 81576 7.83374031 8.12273912 0.00097862 0.03543933 1.1169548 CTAGE5 2114789 7.83374031 8.12273912 0.00097862 0.03543933 1.1169548 FBXO33 2070802 7.64814552 7.75068347 0.00013173 0.02750392 1.11712006 TCL1B 73072 7.64814552 7.75068347 0.00013173 0.02750392 1.11712006 SYNE3 61316 7.64814552 7.75068347 0.00013173 0.02750392 1.11712006 GLRX5 0 7.48564648 7.74982946 0.00017348 0.02750392 1.1403272 TCL1B 38123 7.48564648 7.74982946 0.00017348 0.02750392 1.1403272 TCL1A 61673 7.48564648 7.74982946 0.00017348 0.02750392 1.1403272 GLRX5 64146 7.42766462 7.68725054 0.0009826 0.03543933 1.10244623 TMEM98 29591 7.42766462 7.68725054 0.0009826 0.03543933 1.10244623 SPACA3 72057 7.42766462 7.68725054 0.0009826 0.03543933 1.10244623 MYO1D 0 7.59081015 7.90740058 0.00096445 0.03535882 1.1212903 MBD5 0 7.59081015 7.90740058 0.00096445 0.03535882 1.1212903 ORC4 220015 7.59081015 7.90740058 0.00096445 0.03535882 1.1212903 ACVR2A 310793 7.80313336 8.07765911 0.00019327 0.02750392 1.13367277 SLC4A10 0 7.80313336 8.07765911 0.00019327 0.02750392 1.13367277 PSMD14 25443 7.80313336 8.07765911 0.00019327 0.02750392 1.13367277 TBR1 11290 8.23651424 8.26348434 0.0007252 0.03351912 1.12016585 TTC30A 0 8.23651424 8.26348434 0.0007252 0.03351912 1.12016585 TTC30B 0 8.23651424 8.26348434 0.0007252 0.03351912 1.12016585 PDE11A 0 8.23651424 8.26348434 0.0007252 0.03351912 1.12016585 AGPS 0 7.91552416 7.94742475 0.00076721 0.03351912 1.14072206 TTC30A 9178 7.91552416 7.94742475 0.00076721 0.03351912 1.14072206 TTC30B 75130 7.91552416 7.94742475 0.00076721 0.03351912 1.14072206 PDE11A 0 7.57506947 7.76346675 9.6156E-05 0.02750392 1.11962478 SF3B1 0 7.57506947 7.76346675 9.6156E-05 0.02750392 1.11962478 HSPD1 0 7.57506947 7.76346675 9.6156E-05 0.02750392 1.11962478 ANKRD44 0 7.57506947 7.76346675 9.6156E-05 0.02750392 1.11962478 COQ10B 0 7.57506947 7.76346675 9.6156E-05 0.02750392 1.11962478 HSPE1 0 7.57506947 7.76346675 9.6156E-05 0.02750392 1.11962478 HSPE1- 0 MOB4 8.04785654 8.09765535 0.0004692 0.03033466 1.10900062 ILKAP 0 8.04785654 8.09765535 0.0004692 0.03033466 1.10900062 HES6 20220 8.04785654 8.09765535 0.0004692 0.03033466 1.10900062 FAM132B 17174 7.98226955 8.24599329 3.215E-05 0.02750392 1.16671118 GALNT14 0 7.98226955 8.24599329 3.215E-05 0.02750392 1.16671118 CAPN14 83851 7.98226955 8.24599329 3.215E-05 0.02750392 1.16671118 EHD3 145132 7.92692902 8.18587543 3.14E-06 0.02750392 1.21068927 GALNT14 0 7.92692902 8.18587543 3.14E-06 0.02750392 1.21068927 CAPN14 0 7.92692902 8.18587543 3.14E-06 0.02750392 1.21068927 EHD3 47669 7.59506084 7.91375237 2.5327E-06 0.02750392 1.22694508 GALNT14 0 7.59506084 7.91375237 2.5327E-06 0.02750392 1.22694508 EHD3 0 7.59506084 7.91375237 2.5327E-06 0.02750392 1.22694508 CAPN14 0 7.86815163 8.13280425 0.00083217 0.03421145 1.10685878 ETAA1 58284 7.86815163 8.13280425 0.00083217 0.03421145 1.10685878 MEIS1 577819 7.86815163 8.13280425 0.00083217 0.03421145 1.10685878 C1D 702095 7.97078259 8.20399072 0.00074125 0.03351912 1.11633751 LRRTM4 174742 7.97078259 8.20399072 0.00074125 0.03351912 1.11633751 REG1B 1115734 7.97078259 8.20399072 0.00074125 0.03351912 1.11633751 REG3G 1056390 7.89812434 8.2591533 0.0007623 0.03351912 1.14071283 IGLL1 0 7.89812434 8.2591533 0.0007623 0.03351912 1.14071283 DRICH1 0 7.89812434 8.2591533 0.0007623 0.03351912 1.14071283 RGL4 14315 8.39903501 8.46123255 0.0003613 0.0291779 1.12465993 TBC1D22A 307824 8.39903501 8.46123255 0.0003613 0.0291779 1.12465993 FP325331.1 366306 8.39903501 8.46123255 0.0003613 0.0291779 1.12465993 U51561.1 567615 7.43534426 7.64861811 0.0003676 0.0291779 1.1012933 SGOL1 80007 7.43534426 7.64861811 0.0003676 0.0291779 1.1012933 PP2D1 253969 7.43534426 7.64861811 0.0003676 0.0291779 1.1012933 KAT2B 111895 8.26920156 8.51618625 0.00055747 0.03145983 1.10573248 ARL8B 196370 8.26920156 8.51618625 0.00055747 0.03145983 1.10573248 ITPR1 0 8.26920156 8.51618625 0.00055747 0.03145983 1.10573248 BHLHE40 53266 8.01306213 8.19056675 5.7251E-05 0.02750392 1.11859591 FGFBP2 0 8.01306213 8.19056675 5.7251E-05 0.02750392 1.11859591 PROM1 0 8.01306213 8.19056675 5.7251E-05 0.02750392 1.11859591 FGFBP1 0 8.01306213 8.19056675 5.7251E-05 0.02750392 1.11859591 CD38 0 7.97319093 8.13500536 4.4122E-05 0.02750392 1.13664922 FGFBP2 0 7.97319093 8.13500536 4.4122E-05 0.02750392 1.13664922 PROM1 0 7.97319093 8.13500536 4.4122E-05 0.02750392 1.13664922 FGFBP1 0 7.97319093 8.13500536 4.4122E-05 0.02750392 1.13664922 CD38 0 8.14888128 8.2783721 0.00017804 0.02750392 1.11332579 FGFBP1 0 8.14888128 8.2783721 0.00017804 0.02750392 1.11332579 PROM1 0 8.14888128 8.2783721 0.00017804 0.02750392 1.11332579 FGFBP2 0 8.0068876 8.14829802 8.2205E-05 0.02750392 1.10893122 PROM1 0 8.0068876 8.14829802 8.2205E-05 0.02750392 1.10893122 FGFBP2 0 8.0068876 8.14829802 8.2205E-05 0.02750392 1.10893122 FGFBP1 0 8.14524049 8.29604205 4.2562E-05 0.02750392 1.13039169 FGFBP1 0 8.14524049 8.29604205 4.2562E-05 0.02750392 1.13039169 FGFBP2 0 8.14524049 8.29604205 4.2562E-05 0.02750392 1.13039169 PROM1 0 7.92274968 8.14127884 0.00029205 0.02900908 1.14056632 FGFBP2 0 7.92274968 8.14127884 0.00029205 0.02900908 1.14056632 FGFBP1 0 7.92274968 8.14127884 0.00029205 0.02900908 1.14056632 PROM1 0 7.92322595 8.16025619 0.00031214 0.02900908 1.11459728 FGFBP1 24835 7.92322595 8.16025619 0.00031214 0.02900908 1.11459728 FGFBP2 0 7.92322595 8.16025619 0.00031214 0.02900908 1.11459728 PROM1 0 8.06177822 8.16685931 0.00010015 0.02750392 1.12334898 FGFBP1 24835 8.06177822 8.16685931 0.00010015 0.02750392 1.12334898 PROM1 0 8.06177822 8.16685931 0.00010015 0.02750392 1.12334898 FGFBP2 0 7.97721945 8.16381757 0.00020259 0.02750392 1.10090253 FGFBP1 24835 7.97721945 8.16381757 0.00020259 0.02750392 1.10090253 PROM1 0 7.97721945 8.16381757 0.00020259 0.02750392 1.10090253 FGFBP2 0 8.19760229 8.32379174 0.00010669 0.02750392 1.10459654 FGFBP2 0 8.19760229 8.32379174 0.00010669 0.02750392 1.10459654 PROM1 0 8.19760229 8.32379174 0.00010669 0.02750392 1.10459654 FGFBP1 24835 8.27711512 8.39135771 0.00013771 0.02750392 1.11049667 FGFBP2 0 8.27711512 8.39135771 0.00013771 0.02750392 1.11049667 PROM1 0 8.27711512 8.39135771 0.00013771 0.02750392 1.11049667 FGFBP1 24835 8.04680193 8.25833923 6.3739E-05 0.02750392 1.12648756 PROM1 0 8.04680193 8.25833923 6.3739E-05 0.02750392 1.12648756 TAPT1 0 8.04680193 8.25833923 6.3739E-05 0.02750392 1.12648756 FGFBP2 0 8.07023378 8.41864619 0.00080758 0.03387289 1.13457506 CWH43 461197 8.07023378 8.41864619 0.00080758 0.03387289 1.13457506 OCIAD2 616341 8.07023378 8.41864619 0.00080758 0.03387289 1.13457506 OCIAD1 661461 7.67262958 7.81335006 0.00020294 0.02750392 1.10066756 GABRP 0 7.67262958 7.81335006 0.00020294 0.02750392 1.10066756 RANBP17 93377 7.67262958 7.81335006 0.00020294 0.02750392 1.10066756 KCNIP1 0 8.18762757 8.35457017 0.00037438 0.0291779 1.10710796 BASP1 759015 8.18762757 8.35457017 0.00037438 0.0291779 1.10710796 MYO10 1099582 8.18762757 8.35457017 0.00037438 0.0291779 1.10710796 CDH18 1207295 8.32192196 8.47895331 8.6014E-05 0.02750392 1.12645632 AGR3 301792 8.32192196 8.47895331 8.6014E-05 0.02750392 1.12645632 AGR2 350346 8.32192196 8.47895331 8.6014E-05 0.02750392 1.12645632 AHR 0 8.35135973 8.47506867 0.00011693 0.02750392 1.14418074 NPY 0 8.35135973 8.47506867 0.00011693 0.02750392 1.14418074 MPP6 276617 8.35135973 8.47506867 0.00011693 0.02750392 1.14418074 STK31 191006 8.22663408 8.4915587 0.00040049 0.0291779 1.12326243 FAM110B 52547 8.22663408 8.4915587 0.00040049 0.0291779 1.12326243 UBXN2B 469302 8.22663408 8.4915587 0.00040049 0.0291779 1.12326243 CYP7A1 548216 8.18061241 8.46593611 0.00054336 0.03136089 1.12107431 FAM110B 85424 8.18061241 8.46593611 0.00054336 0.03136089 1.12107431 UBXN2B 0 8.18061241 8.46593611 0.00054336 0.03136089 1.12107431 CYP7A1 43815 8.41122857 8.48511938 0.00039357 0.0291779 1.14851694 TMEM246 0 8.41122857 8.48511938 0.00039357 0.0291779 1.14851694 RNF20 0 8.41122857 8.48511938 0.00039357 0.0291779 1.14851694 ZNF189 0 8.41122857 8.48511938 0.00039357 0.0291779 1.14851694 ALDOB 0 8.41419562 8.44045216 0.00060198 0.03221946 1.15117994 RNF20 0 8.41419562 8.44045216 0.00060198 0.03221946 1.15117994 PPP3R2 0 8.41419562 8.44045216 0.00060198 0.03221946 1.15117994 GRIN3A 0 0 8.33861824 8.39984043 0.00056335 0.03164914 1.12646144 MAGEB5 29501 8.33861824 8.39984043 0.00056335 0.03164914 1.12646144 MAGEB18 431992 8.33861824 8.39984043 0.00056335 0.03164914 1.12646144 MAGEB6 03 8.06769641 8.25165082 0.00026184 0.02831289 1.10329629 FTHL17 04 8.06769641 8.25165082 0.00026184 0.02831289 1.10329629 DMD 176935 8.06769641 8.25165082 0.00026184 0.02831289 1.10329629 TAB3 725786 7.63110616 7.79785213 0.00030954 0.02900908 1.10210679 MAGEE1 2477287 7.63110616 7.79785213 0.00030954 0.02900908 1.10210679 PBDC1 08 7.63110616 7.79785213 0.00030954 0.02900908 1.10210679 MAGEE2 1981379 7.7387039 7.99425689 0.00029242 0.02900908 1.11749818 PBDC1 00 7.7387039 7.99425689 0.00029242 0.02900908 1.11749818 MAGEE1 2477281 7.7387039 7.99425689 0.00029242 0.02900908 1.11749818 MAGEE2 223767 Table 2(a) probe T1 T2 1 Hg38_1_100775373_100782789_100869862_100872482_RF 8.504694 8.623054 2 Hg38_1_100775373_100782789_100869862_100872482_RF 8.504694 8.623054 3 Hg38_1_100775373_100782789_100869862_100872482_RF 8.504694 8.623054 4 Hg38_1_147467275_147473384_147709076_147716288_RR 8.293391 8.473109 5 Hg38_1_147467275_147473384_147709076_147716288_RR 8.293391 8.473109 6 Hg38_1_147467275_147473384_147709076_147716288_RR 8.293391 8.473109 7 Hg38_1_219761446_219768171_219890470_219894033_FR 8.360783 8.602835 8 Hg38_1_219761446_219768171_219890470_219894033_FR 8.360783 8.602835 9 Hg38_1_219761446_219768171_219890470_219894033_FR 8.360783 8.602835 10 Hg38_1_51338583_51347838_51381390_51386653_FF 8.826966 8.943416 11 Hg38_1_51338583_51347838_51381390_51386653_FF 8.826966 8.943416 12 Hg38_1_51338583_51347838_51381390_51386653_FF 8.826966 8.943416 13 Hg38_10_42175765_42181242_42438160_42444168_FR 8.718677 8.878836 14 Hg38_10_42175765_42181242_42438160_42444168_FR 8.718677 8.878836 15 Hg38_10_42175765_42181242_42438160_42444168_FR 8.718677 8.878836 16 Hg38_10_42358592_42364764_42438160_42444168_FR 8.260729 8.514686 17 Hg38_10_42358592_42364764_42438160_42444168_FR 8.260729 8.514686 18 Hg38_10_42358592_42364764_42438160_42444168_FR 8.260729 8.514686 19 Hg38_11_131282947_131287817_131314179_131324777_RR 8.634959 8.823014 20 Hg38_11_131282947_131287817_131314179_131324777_RR 8.634959 8.823014 21 Hg38_11_131282947_131287817_131314179_131324777_RR 8.634959 8.823014 22 Hg38_11_31954840_31959091_32230148_32243760_RR 8.415454 8.61216 23 Hg38_11_31954840_31959091_32230148_32243760_RR 8.415454 8.61216 24 Hg38_11_31954840_31959091_32230148_32243760_RR 8.415454 8.61216 25 Hg38_11_93057516_93069988_93115381_93124900_FR 8.428977 8.562224 26 Hg38_11_93057516_93069988_93115381_93124900_FR 8.428977 8.562224 27 Hg38_11_93057516_93069988_93115381_93124900_FR 8.428977 8.562224 28 Hg38_12_123422833_123425871_123491802_123494537_RF 8.826454 9.037695 29 Hg38_12_123422833_123425871_123491802_123494537_RF 8.826454 9.037695 Hg38_12_123422833_123425871_123491802_123494537_RF 8.826454 9.037695 Hg38_12_123491802_123494537_123514233_123517939_FF 8.817062 9.012882 Hg38_12_123491802_123494537_123514233_123517939_FF 8.817062 9.012882 Hg38_12_123491802_123494537_123514233_123517939_FF 8.817062 9.012882 Hg38_12_123491802_123494537_123594685_123598599_FF 8.701329 8.960663 Hg38_12_123491802_123494537_123594685_123598599_FF 8.701329 8.960663 Hg38_12_123491802_123494537_123594685_123598599_FF 8.701329 8.960663 Hg38_12_123491802_123494537_123668352_123671418_FR 8.67952 8.916568 Hg38_12_123491802_123494537_123668352_123671418_FR 8.67952 8.916568 Hg38_12_123491802_123494537_123668352_123671418_FR 8.67952 8.916568 Hg38_12_123491802_123494537_123668352_123671418_FR 8.67952 8.916568 Hg38_12_123491802_123494537_123668352_123671418_FR 8.67952 8.916568 Hg38_12_123491802_123494537_123668352_123671418_FR 8.67952 8.916568 Hg38_12_20768546_20775250_20902866_20914748_RF 8.179675 8.291036 Hg38_12_20768546_20775250_20902866_20914748_RF 8.179675 8.291036 Hg38_12_20768546_20775250_20902866_20914748_RF 8.179675 8.291036 Hg38_13_37787963_37794369_37908661_37915528_RR 8.009088 8.252463 Hg38_13_37787963_37794369_37908661_37915528_RR 8.009088 8.252463 Hg38_13_37787963_37794369_37908661_37915528_RR 8.009088 8.252463 Hg38_13_98734296_98740861_98787911_98794240_RR 8.704501 8.870639 Hg38_13_98734296_98740861_98787911_98794240_RR 8.704501 8.870639 Hg38_13_98734296_98740861_98787911_98794240_RR 8.704501 8.870639 Hg38_17_36392749_36396192_36546757_36549955_RR 8.25584 8.41453 Hg38_17_36392749_36396192_36546757_36549955_RR 8.25584 8.41453 Hg38_17_36392749_36396192_36546757_36549955_RR 8.25584 8.41453 Hg38_17_36392749_36396192_36546757_36549955_RR 8.25584 8.41453 Hg38_17_36392749_36396192_36546757_36549955_RR 8.25584 8.41453 Hg38_17_36392749_36396192_36546757_36549955_RR 8.25584 8.41453 Hg38_17_36392749_36396192_36546757_36549955_RR 8.25584 8.41453 Hg38_19_7546426_7548469_7671553_7674708_FF 8.687955 8.847599 Hg38_19_7546426_7548469_7671553_7674708_FF 8.687955 8.847599 Hg38_19_7546426_7548469_7671553_7674708_FF 8.687955 8.847599 Hg38_19_7546426_7548469_7671553_7674708_FF 8.687955 8.847599 Hg38_19_7546426_7548469_7671553_7674708_FF 8.687955 8.847599 Hg38_19_7546426_7548469_7671553_7674708_FF 8.687955 8.847599 Hg38_19_7546426_7548469_7671553_7674708_FF 8.687955 8.847599 Hg38_19_7546426_7548469_7671553_7674708_FF 8.687955 8.847599 Hg38_2_31085435_31089206_31124546_31132968_FF 8.133507 8.320804 Hg38_2_31085435_31089206_31124546_31132968_FF 8.133507 8.320804 Hg38_2_31085435_31089206_31124546_31132968_FF 8.133507 8.320804 Hg38_2_64184091_64192231_64253945_64262157_RR 8.55229 8.666655 Hg38_2_64184091_64192231_64253945_64262157_RR 8.55229 8.666655 Hg38_2_64184091_64192231_64253945_64262157_RR 8.55229 8.666655 Hg38_2_6879840_6886093_6903602_6913679_FF 8.69056 8.97342 Hg38_2_6879840_6886093_6903602_6913679_FF 8.69056 8.97342 Hg38_2_6879840_6886093_6903602_6913679_FF 8.69056 8.97342 Hg38_2_71071736_71078154_71158813_71164001_FR 8.8095 8.898371 Hg38_2_71071736_71078154_71158813_71164001_FR 8.8095 8.898371 Hg38_2_71071736_71078154_71158813_71164001_FR 8.8095 8.898371 Hg38_21_24960479_24970716_25131347_25140374_FR 8.524333 8.631439 Hg38_21_24960479_24970716_25131347_25140374_FR 8.524333 8.631439 Hg38_21_24960479_24970716_25131347_25140374_FR 8.524333 8.631439 Hg38_21_25131347_25140374_25332076_25334340_RF 8.626507 8.762998 Hg38_21_25131347_25140374_25332076_25334340_RF 8.626507 8.762998 Hg38_21_25131347_25140374_25332076_25334340_RF 8.626507 8.762998 Hg38_22_47501191_47514798_47635286_47637852_FF 8.413339 8.672104 Hg38_22_47501191_47514798_47635286_47637852_FF 8.413339 8.672104 Hg38_22_47501191_47514798_47635286_47637852_FF 8.413339 8.672104 Hg38_3_105237586_105242212_105298817_105304648_FR 8.317193 8.483282 Hg38_3_105237586_105242212_105298817_105304648_FR 8.317193 8.483282 Hg38_3_105237586_105242212_105298817_105304648_FR 8.317193 8.483282 Hg38_3_148359289_148372839_148415745_148420568_FR 8.215189 8.399021 Hg38_3_148359289_148372839_148415745_148420568_FR 8.215189 8.399021 Hg38_3_148359289_148372839_148415745_148420568_FR 8.215189 8.399021 Hg38_3_166501523_166505146_166596603_166605584_RF 8.432566 8.583954 Hg38_3_166501523_166505146_166596603_166605584_RF 8.432566 8.583954 Hg38_3_166501523_166505146_166596603_166605584_RF 8.432566 8.583954 Hg38_3_170739637_170745909_170825319_170830139_RF 8.63418 8.871504 Hg38_3_170739637_170745909_170825319_170830139_RF 8.63418 8.871504 Hg38_3_170739637_170745909_170825319_170830139_RF 8.63418 8.871504 Hg38_3_89855596_89862325_89997363_90005062_RR 8.722767 8.852133 Hg38_3_89855596_89862325_89997363_90005062_RR 8.722767 8.852133 Hg38_3_89855596_89862325_89997363_90005062_RR 8.722767 8.852133 Hg38_3_89913003_89917338_89997363_90005062_RR 8.731131 8.917902 Hg38_3_89913003_89917338_89997363_90005062_RR 8.731131 8.917902 Hg38_3_89913003_89917338_89997363_90005062_RR 8.731131 8.917902 Hg38_3_89927315_89934985_89997363_90005062_FR 8.120172 8.426067 Hg38_3_89927315_89934985_89997363_90005062_FR 8.120172 8.426067 Hg38_3_89927315_89934985_89997363_90005062_FR 8.120172 8.426067 Hg38_3_89927315_89934985_89997363_90005062_RR 8.675076 8.830451 Hg38_3_89927315_89934985_89997363_90005062_RR 8.675076 8.830451 Hg38_3_89927315_89934985_89997363_90005062_RR 8.675076 8.830451 Hg38_3_89954961_89958319_89997363_90005062_RR 8.829809 8.953454 Hg38_3_89954961_89958319_89997363_90005062_RR 8.829809 8.953454 Hg38_3_89954961_89958319_89997363_90005062_RR 8.829809 8.953454 Hg38_3_89997363_90005062_90135755_90146084_RF 8.7315 8.877727 Hg38_3_89997363_90005062_90135755_90146084_RF 8.7315 8.877727 Hg38_3_89997363_90005062_90135755_90146084_RF 8.7315 8.877727 Hg38_4_140297372_140306802_140464722_140470011_FR 8.856895 9.054472 Hg38_4_140297372_140306802_140464722_140470011_FR 8.856895 9.054472 Hg38_4_140297372_140306802_140464722_140470011_FR 8.856895 9.054472 Hg38_4_140297372_140306802_140529395_140530868_FR 8.691318 8.831901 Hg38_4_140297372_140306802_140529395_140530868_FR 8.691318 8.831901 Hg38_4_140297372_140306802_140529395_140530868_FR 8.691318 8.831901 Hg38_4_140297372_140306802_140529395_140530868_FR 8.691318 8.831901 Hg38_4_38375655_38382675_38433487_38446888_RR 8.251083 8.397354 Hg38_4_38375655_38382675_38433487_38446888_RR 8.251083 8.397354 Hg38_4_38375655_38382675_38433487_38446888_RR 8.251083 8.397354 Hg38_4_76397769_76407883_76479034_76489605_RR 8.69857 8.866268 Hg38_4_76397769_76407883_76479034_76489605_RR 8.69857 8.866268 Hg38_4_76397769_76407883_76479034_76489605_RR 8.69857 8.866268 Hg38_5_145880267_145890417_145976766_145982424_RF 8.42323 8.523192 Hg38_5_145880267_145890417_145976766_145982424_RF 8.42323 8.523192 Hg38_5_145880267_145890417_145976766_145982424_RF 8.42323 8.523192 Hg38_6_52651682_52659538_52863183_52869884_FR 8.372625 8.524558 Hg38_6_52651682_52659538_52863183_52869884_FR 8.372625 8.524558 Hg38_6_52651682_52659538_52863183_52869884_FR 8.372625 8.524558 Hg38_6_52651682_52659538_52863183_52869884_FR 8.372625 8.524558 Hg38_6_52651682_52659538_52863183_52869884_FR 8.372625 8.524558 Hg38_7_125228274_125236461_125259342_125263240_FF 8.650991 8.74492 Hg38_7_125228274_125236461_125259342_125263240_FF 8.650991 8.74492 Hg38_7_125228274_125236461_125259342_125263240_FF 8.650991 8.74492 Hg38_7_23895068_23897740_24023518_24030634_RF 8.296699 8.344324 Hg38_7_23895068_23897740_24023518_24030634_RF 8.296699 8.344324 Hg38_7_23895068_23897740_24023518_24030634_RF 8.296699 8.344324 Hg38_7_57415950_57420039_57526789_57534246_RR 8.495851 8.777634 Hg38_7_57415950_57420039_57526789_57534246_RR 8.495851 8.777634 Hg38_7_57415950_57420039_57526789_57534246_RR 8.495851 8.777634 Hg38_8_117545815_117563869_117666840_117673392_FF 8.954568 9.076817 Hg38_8_117545815_117563869_117666840_117673392_FF 8.954568 9.076817 Hg38_8_117545815_117563869_117666840_117673392_FF 8.954568 9.076817 Hg38_8_7403832_7404963_7527581_7533629_RF 8.524735 8.71194 Hg38_8_7403832_7404963_7527581_7533629_RF 8.524735 8.71194 Hg38_8_7403832_7404963_7527581_7533629_RF 8.524735 8.71194 Hg38_8_7403832_7404963_7527581_7533629_RF 8.524735 8.71194 Hg38_8_7403832_7404963_7527581_7533629_RF 8.524735 8.71194 Hg38_8_7403832_7404963_7527581_7533629_RF 8.524735 8.71194 Hg38_8_7403832_7404963_7527581_7533629_RF 8.524735 8.71194 Hg38_X_112976452_112982208_113182479_113188695_RF 8.619586 8.816634 Hg38_X_112976452_112982208_113182479_113188695_RF 8.619586 8.816634 Hg38_X_112976452_112982208_113182479_113188695_RF 8.619586 8.816634 Hg38_X_26183933_26198528_26380540_26388329_FF 8.427329 8.621892 162 Hg38_X_26183933_26198528_26380540_26388329_FF 8.427329 8.621892 163 Hg38_X_26183933_26198528_26380540_26388329_FF 8.427329 8.621892 164 Hg38_X_27575403_27590431_27634041_27637533_RR 8.160708 8.380052 165 Hg38_X_27575403_27590431_27634041_27637533_RR 8.160708 8.380052 166 Hg38_X_27575403_27590431_27634041_27637533_RR 8.160708 8.380052 167 Hg38_X_27575403_27590431_27722417_27731201_RR 8.382372 8.578134 168 Hg38_X_27575403_27590431_27722417_27731201_RR 8.382372 8.578134 169 Hg38_X_27575403_27590431_27722417_27731201_RR 8.382372 8.578134 170 Hg38_X_69860711_69864939_70037746_70042437_RR 7.934597 8.344213 171 Hg38_X_69860711_69864939_70037746_70042437_RR 7.934597 8.344213 172 Hg38_X_69860711_69864939_70037746_70042437_RR 7.934597 8.344213 Table 2(b) T3 T4 P.value adj.P.Val FC gene distance 1 8.70746 8.96885 0.000698 0.033519 1.107792 VCAM1 36329 2 8.70746 8.96885 0.000698 0.033519 1.107792 SLC30A7 23595 3 8.70746 8.96885 0.000698 0.033519 1.107792 EXTL2 0 4 8.553219 8.76528 0.000232 0.027504 1.109245 GJA5 39912 5 8.553219 8.76528 0.000232 0.027504 1.109245 BCL9 0 6 8.553219 8.76528 0.000232 0.027504 1.109245 ACP6 0 7 8.645601 8.913139 0.000475 0.030335 1.125046 SLC30A10 0 8 8.645601 8.913139 0.000475 0.030335 1.125046 EPRS 74569 9 8.645601 8.913139 0.000475 0.030335 1.125046 BPNT1 163450 10 9.030345 9.33786 0.000972 0.035431 1.118807 EPS15 0 11 9.030345 9.33786 0.000972 0.035431 1.118807 TTC39A 0 12 9.030345 9.33786 0.000972 0.035431 1.118807 RNF11 65129 13 9.017257 9.360718 0.000234 0.027504 1.153849 BMS1 338634 14 9.017257 9.360718 0.000234 0.027504 1.153849 ZNF33B 130018 15 9.017257 9.360718 0.000234 0.027504 1.153849 RET 632860 16 8.680223 9.099045 7.61E-05 0.027504 1.204178 BMS1 338634 17 8.680223 9.099045 7.61E-05 0.027504 1.204178 RET 632860 18 8.680223 9.099045 7.61E-05 0.027504 1.204178 ZNF33B 130018 19 8.875367 9.204668 0.000755 0.033519 1.129863 NTM 45702 20 8.875367 9.204668 0.000755 0.033519 1.129863 C11orf44 565596 21 8.875367 9.204668 0.000755 0.033519 1.129863 SNX19 366439 22 8.679268 8.882346 0.000303 0.029009 1.107095 WT1 144016 23 8.679268 8.882346 0.000303 0.029009 1.107095 PAX6 136880 24 8.679268 8.882346 0.000303 0.029009 1.107095 RCN1 0 25 8.650472 8.863605 0.000345 0.029178 1.101304 FAT3 161047 26 8.650472 8.863605 0.000345 0.029178 1.101304 MTNR1B 72451 27 8.650472 8.863605 0.000345 0.029178 1.101304 SLC36A4 19272 28 9.109568 9.313716 0.000252 0.028313 1.112161 RILPL1 0 29 9.109568 9.313716 0.000252 0.028313 1.112161 SNRNP35 0 30 9.109568 9.313716 0.000252 0.028313 1.112161 RILPL2 0 9.106236 9.279225 0.00017 0.027504 1.10802 RILPL2 55086 9.106236 9.279225 0.00017 0.027504 1.10802 SNRNP35 18649 9.106236 9.279225 0.00017 0.027504 1.10802 RILPL1 0 9.104358 9.25197 0.000115 0.027504 1.13254 RILPL1 0 9.104358 9.25197 0.000115 0.027504 1.13254 TMED2 0 9.104358 9.25197 0.000115 0.027504 1.13254 DDX55 3479 9.090471 9.213931 0.000102 0.027504 1.13109 TCTN2 0 9.090471 9.213931 0.000102 0.027504 1.13109 RILPL1 0 9.090471 9.213931 0.000102 0.027504 1.13109 EIF2B1 0 9.090471 9.213931 0.000102 0.027504 1.13109 GTF2H3 0 9.090471 9.213931 0.000102 0.027504 1.13109 TMED2 0 9.090471 9.213931 0.000102 0.027504 1.13109 DDX55 0 8.410048 8.703668 0.000534 0.031253 1.124356 SLCO1B3 0 8.410048 8.703668 0.000534 0.031253 1.124356 SLCO1C1 15161 8.410048 8.703668 0.000534 0.031253 1.124356 RP11- 0 545J16.1 8.421832 8.682764 1.85E-05 0.027504 1.163959 TRPC4 0 8.421832 8.682764 1.85E-05 0.027504 1.163959 UFM1 434322 8.421832 8.682764 1.85E-05 0.027504 1.163959 POSTN 189120 9.119886 9.145374 0.000766 0.033519 1.11511 STK24 156357 9.119886 9.145374 0.000766 0.033519 1.11511 DOCK9 0 9.119886 9.145374 0.000766 0.033519 1.11511 SLC15A1 0 8.468446 8.764718 0.000885 0.034849 1.115782 MYO19 0 8.468446 8.764718 0.000885 0.034849 1.115782 TBC1D3F 0 8.468446 8.764718 0.000885 0.034849 1.115782 GGNBP2 0 8.468446 8.764718 0.000885 0.034849 1.115782 TBC1D3H 0 8.468446 8.764718 0.000885 0.034849 1.115782 PIGW 0 8.468446 8.764718 0.000885 0.034849 1.115782 TBC1D3I 0 8.468446 8.764718 0.000885 0.034849 1.115782 ZNHIT3 0 8.920196 9.15492 0.000383 0.029178 1.107533 CTD- 0 3214H19.4 8.920196 9.15492 0.000383 0.029178 1.107533 XAB2 0 8.920196 9.15492 0.000383 0.029178 1.107533 RETN 0 8.920196 9.15492 0.000383 0.029178 1.107533 PET100 0 8.920196 9.15492 0.000383 0.029178 1.107533 PCP2 0 8.920196 9.15492 0.000383 0.029178 1.107533 STXBP2 0 8.920196 9.15492 0.000383 0.029178 1.107533 CAMSAP3 0 8.920196 9.15492 0.000383 0.029178 1.107533 PNPLA6 0 8.536197 8.695811 2.78E-05 0.027504 1.140946 CAPN14 40089 8.536197 8.695811 2.78E-05 0.027504 1.140946 GALNT14 0 8.536197 8.695811 2.78E-05 0.027504 1.140946 EHD3 101370 8.760809 9.052552 0.000782 0.033565 1.116895 LGALSL 191813 8.760809 9.052552 0.000782 0.033565 1.116895 VPS54 165020 8.760809 9.052552 0.000782 0.033565 1.116895 PELI1 39638 9.070113 9.190705 0.000612 0.032219 1.117065 CMPK2 13206 9.070113 9.190705 0.000612 0.032219 1.117065 RSAD2 0 9.070113 9.190705 0.000612 0.032219 1.117065 RNF144A 3714 9.003367 9.244253 0.000748 0.033519 1.102612 MCEE 0 9.003367 9.244253 0.000748 0.033519 1.102612 MPHOSPH10 0 9.003367 9.244253 0.000748 0.033519 1.102612 NAGK 0 8.820847 8.941908 0.000156 0.027504 1.105128 JAM2 498899 8.820847 8.941908 0.000156 0.027504 1.105128 ATP5J 576130 8.820847 8.941908 0.000156 0.027504 1.105128 MRPL39 445283 8.890992 9.042759 0.000129 0.027504 1.100131 ATP5J 382164 8.890992 9.042759 0.000129 0.027504 1.100131 JAM2 304933 8.890992 9.042759 0.000129 0.027504 1.100131 MRPL39 251317 8.794756 8.864191 0.000994 0.035439 1.107664 U51561.1 585284 8.794756 8.864191 0.000994 0.035439 1.107664 FP325331.1 383975 8.794756 8.864191 0.000994 0.035439 1.107664 TBC1D22A 325493 8.534913 8.769271 0.00062 0.032219 1.102506 ALCAM 62262 8.534913 8.769271 0.00062 0.032219 1.102506 CCDC54 2072547 8.534913 8.769271 0.00062 0.032219 1.102506 CBLB 350814 8.462334 8.740152 0.000452 0.030193 1.12025 CPA3 444689 8.462334 8.740152 0.000452 0.030193 1.12025 CPB1 370535 8.462334 8.740152 0.000452 0.030193 1.12025 AGTR1 277217 8.683775 9.103447 0.000968 0.035359 1.157688 ZBBX 634704 8.683775 9.103447 0.000968 0.035359 1.157688 SERPINI2 836206 8.683775 9.103447 0.000968 0.035359 1.157688 BCHE 664052 8.932561 9.078938 0.000635 0.032592 1.101549 RPL22L1 34737 8.932561 9.078938 0.000635 0.032592 1.101549 CLDN11 0 8.932561 9.078938 0.000635 0.032592 1.101549 EIF5A2 58277 8.985151 9.380582 0.000703 0.033519 1.157206 C3orf38 1686868 8.985151 9.380582 0.000703 0.033519 1.157206 CGGBP1 1705712 8.985151 9.380582 0.000703 0.033519 1.157206 EPHA3 373463 9.134966 9.525934 7.48E-05 0.027504 1.197601 EPHA3 430870 9.134966 9.525934 7.48E-05 0.027504 1.197601 C3orf38 1744275 9.134966 9.525934 7.48E-05 0.027504 1.197601 CGGBP1 1763119 8.621782 8.942622 1.03E-05 0.027504 1.202725 C3orf38 1758587 8.621782 8.942622 1.03E-05 0.027504 1.202725 EPHA3 445182 8.621782 8.942622 1.03E-05 0.027504 1.202725 CGGBP1 1777431 9.014045 9.397676 0.000195 0.027504 1.17702 EPHA3 445182 9.014045 9.397676 0.000195 0.027504 1.17702 CGGBP1 1777431 9.014045 9.397676 0.000195 0.027504 1.17702 C3orf38 1758587 9.066865 9.422861 0.000772 0.033519 1.140176 C3orf38 1786233 9.066865 9.422861 0.000772 0.033519 1.140176 EPHA3 472828 9.066865 9.422861 0.000772 0.033519 1.140176 CGGBP1 1805077 8.992133 9.424111 0.000915 0.034857 1.164107 C3orf38 1828635 8.992133 9.424111 0.000915 0.034857 1.164107 EPHA3 515230 8.992133 9.424111 0.000915 0.034857 1.164107 CGGBP1 1847479 9.263733 9.304442 0.00059 0.032205 1.113568 CLGN 0 9.263733 9.304442 0.00059 0.032205 1.113568 SCOC 0 9.263733 9.304442 0.00059 0.032205 1.113568 MGAT4D 0 9.089966 9.134509 0.000527 0.031125 1.11633 SCOC 0 9.089966 9.134509 0.000527 0.031125 1.11633 ELMOD2 0 9.089966 9.134509 0.000527 0.031125 1.11633 CLGN 0 9.089966 9.134509 0.000527 0.031125 1.11633 MGAT4D 0 8.453599 8.712018 0.000807 0.033873 1.104892 TBC1D1 236481 8.453599 8.712018 0.000807 0.033873 1.104892 KLF3 217309 8.453599 8.712018 0.000807 0.033873 1.104892 TLR10 325352 8.911861 9.215904 0.000989 0.035439 1.117101 SHROOM3 0 8.911861 9.215904 0.000989 0.035439 1.117101 CCDC158 0 8.911861 9.215904 0.000989 0.035439 1.117101 FAM47E- 86171 STBD1 8.620731 8.901595 0.000905 0.034857 1.112082 PRELID2 44899 8.620731 8.901595 0.000905 0.034857 1.112082 SH3RF2 0 8.620731 8.901595 0.000905 0.034857 1.112082 GRXCR2 7300 8.578008 8.854534 0.000879 0.034785 1.109506 GSTA5 0 8.578008 8.854534 0.000879 0.034785 1.109506 GSTA3 0 8.578008 8.854534 0.000879 0.034785 1.109506 GSTA1 0 8.578008 8.854534 0.000879 0.034785 1.109506 TMEM14A 0 8.578008 8.854534 0.000879 0.034785 1.109506 GSTA2 0 8.852449 9.147884 0.000957 0.035294 1.117148 GPR37 462648 8.852449 9.147884 0.000957 0.035294 1.117148 RP5- 437465 907C10.4 8.852449 9.147884 0.000957 0.035294 1.117148 POT1 298292 8.52005 8.720122 0.000638 0.032592 1.105424 CCDC126 250361 8.52005 8.720122 0.000638 0.032592 1.105424 FAM221A 191820 8.52005 8.720122 0.000638 0.032592 1.105424 STK31 62556 8.947957 9.009823 0.00072 0.033519 1.126013 AC118758.1 611262 8.947957 9.009823 0.00072 0.033519 1.126013 ZNF716 0 8.947957 9.009823 0.00072 0.033519 1.126013 ZNF479 276087 9.153067 9.448547 0.000988 0.035439 1.114054 EXT1 121099 9.153067 9.448547 0.000988 0.035439 1.114054 SLC30A8 369102 9.153067 9.448547 0.000988 0.035439 1.114054 MED30 5554 8.744492 9.029898 0.000975 0.035432 1.11327 DEFB4B 0 8.744492 9.029898 0.000975 0.035432 1.11327 SPAG11B 0 8.744492 9.029898 0.000975 0.035432 1.11327 DEFB103B 0 8.744492 9.029898 0.000975 0.035432 1.11327 DEFB106B 0 8.744492 9.029898 0.000975 0.035432 1.11327 DEFB107B 0 8.744492 9.029898 0.000975 0.035432 1.11327 DEFB104B 0 8.744492 9.029898 0.000975 0.035432 1.11327 DEFB105B 0 8.980039 9.043254 0.00046 0.030193 1.104536 LHFPL1 296399 8.980039 9.043254 0.00046 0.030193 1.104536 AMOT 135638 8.980039 9.043254 0.00046 0.030193 1.104536 ZCCHC16 519341 161 8.798814 8.839178 0.000764 0.033519 1.102858 MAGEB5 0 162 8.798814 8.839178 0.000764 0.033519 1.102858 MAGEB6 0 163 8.798814 8.839178 0.000764 0.033519 1.102858 MAGEB18 43199 164 8.501104 8.623518 0.000215 0.027504 1.110299 MAGEB10 170458 165 8.501104 8.623518 0.000215 0.027504 1.110299 DCAF8L2 0 166 8.501104 8.623518 0.000215 0.027504 1.110299 DCAF8L1 340461 167 8.673468 8.811737 0.000246 0.02817 1.10064 DCAF8L2 0 168 8.673468 8.811737 0.000246 0.02817 1.10064 DCAF8L1 246793 169 8.673468 8.811737 0.000246 0.02817 1.10064 MAGEB10 76790 170 8.381723 8.658162 0.000667 0.03299 1.165396 AWAT2 0 171 8.381723 8.658162 0.000667 0.03299 1.165396 EDA 0 172 8.381723 8.658162 0.000667 0.03299 1.165396 OTUD6A 20055 Table 3(a) Probe T1 T2 1 Hg38_1_88983243_88987931_89019145_89024295_RF 6.948637 7.244023 2 Hg38_1_88983243_88987931_89019145_89024295_RF 6.948637 7.244023 3 Hg38_1_88983243_88987931_89019145_89024295_RF 6.948637 7.244023 4 Hg38_1_89019145_89024295_89092008_89101346_FF 6.279052 6.720724 5 Hg38_1_89019145_89024295_89092008_89101346_FF 6.279052 6.720724 6 Hg38_1_89019145_89024295_89092008_89101346_FF 6.279052 6.720724 7 Hg38_11_4858061_4859931_4915318_4921678_RF 6.985171 7.138414 8 Hg38_11_4858061_4859931_4915318_4921678_RF 6.985171 7.138414 9 Hg38_11_4858061_4859931_4915318_4921678_RF 6.985171 7.138414 10 Hg38_11_4858061_4859931_4915318_4921678_RF 6.985171 7.138414 11 Hg38_11_4858061_4859931_4915318_4921678_RF 6.985171 7.138414 12 Hg38_12_18612703_18622709_18849029_18862608_RF 6.712119 6.874986 13 Hg38_12_18612703_18622709_18849029_18862608_RF 6.712119 6.874986 14 Hg38_12_18612703_18622709_18849029_18862608_RF 6.712119 6.874986 15 Hg38_12_25433725_25436828_25611482_25622202_FR 7.082469 7.12408 16 Hg38_12_25433725_25436828_25611482_25622202_FR 7.082469 7.12408 17 Hg38_12_25433725_25436828_25611482_25622202_FR 7.082469 7.12408 18 Hg38_2_177553232_177557574_177742494_177747277_RF 6.974654 7.181553 19 Hg38_2_177553232_177557574_177742494_177747277_RF 6.974654 7.181553 20 Hg38_2_177553232_177557574_177742494_177747277_RF 6.974654 7.181553 21 Hg38_2_207487176_207493120_207741315_207746773_FR 6.570701 6.820617 22 Hg38_2_207487176_207493120_207741315_207746773_FR 6.570701 6.820617 23 Hg38_2_207487176_207493120_207741315_207746773_FR 6.570701 6.820617 24 Hg38_2_3202466_3204529_3395193_3404401_FF 6.132704 6.33093 25 Hg38_2_3202466_3204529_3395193_3404401_FF 6.132704 6.33093 26 Hg38_2_3202466_3204529_3395193_3404401_FF 6.132704 6.33093 27 Hg38_3_40205500_40210587_40317159_40327036_FR 6.314552 6.464555 28 Hg38_3_40205500_40210587_40317159_40327036_FR 6.314552 6.464555 29 Hg38_3_40205500_40210587_40317159_40327036_FR 6.314552 6.464555 30 Hg38_5_170763313_170768494_170976178_170988263_FR 6.772774 6.865747 31 Hg38_5_170763313_170768494_170976178_170988263_FR 6.772774 6.865747 32 Hg38_5_170763313_170768494_170976178_170988263_FR 6.772774 6.865747 33 Hg38_5_29206123_29214504_29373418_29375856_RR 6.714238 6.877325 34 Hg38_5_29206123_29214504_29373418_29375856_RR 6.714238 6.877325 35 Hg38_5_29206123_29214504_29373418_29375856_RR 6.714238 6.877325 36 Hg38_6_46584884_46589452_46667413_46671146_RR 6.988559 7.167088 37 Hg38_6_46584884_46589452_46667413_46671146_RR 6.988559 7.167088 38 Hg38_6_46584884_46589452_46667413_46671146_RR 6.988559 7.167088 39 Hg38_6_46584884_46589452_46697190_46700361_RR 6.828239 7.046656 40 Hg38_6_46584884_46589452_46697190_46700361_RR 6.828239 7.046656 41 Hg38_6_46584884_46589452_46697190_46700361_RR 6.828239 7.046656 42 Hg38_7_24030634_24037846_24291036_24296652_RR 6.917351 7.004174 43 Hg38_7_24030634_24037846_24291036_24296652_RR 6.917351 7.004174 44 Hg38_7_24030634_24037846_24291036_24296652_RR 6.917351 7.004174 45 Hg38_9_122460239_122466050_122525905_122533120_FF 7.095641 7.232595 46 Hg38_9_122460239_122466050_122525905_122533120_FF 7.095641 7.232595 47 Hg38_9_122460239_122466050_122525905_122533120_FF 7.095641 7.232595 48 Hg38_9_122460239_122466050_122525905_122533120_FF 7.095641 7.232595 Table 3(b) T3 T4 P.value adj.P.Val FC gene distance 1 7.32249 7.606672 0.000173 0.027504 1.152892 CCBL2 0 2 7.32249 7.606672 0.000173 0.027504 1.152892 GBP3 0 3 7.32249 7.606672 0.000173 0.027504 1.152892 RBMXL1 0 4 6.752355 7.027036 0.000868 0.034559 1.170852 GBP2 4787 5 6.752355 7.027036 0.000868 0.034559 1.170852 GBP1 0 6 6.752355 7.027036 0.000868 0.034559 1.170852 GBP3 0 7 7.266124 7.512382 0.000124 0.027504 1.125788 OR51A7 0 8 7.266124 7.512382 0.000124 0.027504 1.125788 OR51T1 0 9 7.266124 7.512382 0.000124 0.027504 1.125788 OR51G2 0 10 7.266124 7.512382 0.000124 0.027504 1.125788 MMP26 0 11 7.266124 7.512382 0.000124 0.027504 1.125788 OR51H1 0 12 7.060198 7.142571 0.00021 0.027504 1.107769 PIK3C2G 0 13 7.060198 7.142571 0.00021 0.027504 1.107769 CAPZA3 0 14 7.060198 7.142571 0.00021 0.027504 1.107769 PLCZ1 0 15 7.473957 7.587154 0.000783 0.033565 1.137915 LYRM5 224081 16 7.473957 7.587154 0.000783 0.033565 1.137915 KRAS 182790 17 7.473957 7.587154 0.000783 0.033565 1.137915 LMNTD1 0 18 7.39567 7.431449 0.000665 0.03299 1.116087 PDE11A 0 19 7.39567 7.431449 0.000665 0.03299 1.116087 TTC30A 0 20 7.39567 7.431449 0.000665 0.03299 1.116087 TTC30B 219 21 6.969535 7.080464 0.000221 0.027504 1.12336 METTL21A 0 22 6.969535 7.080464 0.000221 0.027504 1.12336 CCNYL1 0 23 6.969535 7.080464 0.000221 0.027504 1.12336 CREB1 0 24 6.736362 6.796323 0.000331 0.029178 1.180689 ADI1 92961 25 6.736362 6.796323 0.000331 0.029178 1.180689 TSSC1 0 26 6.736362 6.796323 0.000331 0.029178 1.180689 TRAPPC12 0 27 6.515947 6.760122 0.000802 0.033727 1.100997 MYRIP 0 28 6.515947 6.760122 0.000802 0.033727 1.100997 ENTPD3 60121 29 6.515947 6.760122 0.000802 0.033727 1.100997 EIF1B 0 30 7.052176 7.23721 0.000155 0.027504 1.115719 KCNIP1 26682 31 7.052176 7.23721 0.000155 0.027504 1.115719 RANBP17 0 32 7.052176 7.23721 0.000155 0.027504 1.115719 GABRP 0 33 6.972755 7.159973 0.000176 0.027504 1.1044 DROSHA 2024642 34 6.972755 7.159973 0.000176 0.027504 1.1044 CDH9 2084974 35 6.972755 7.159973 0.000176 0.027504 1.1044 CDH6 1817895 36 7.251644 7.538249 0.000306 0.029009 1.127684 CYP39A1 0 37 7.251644 7.538249 0.000306 0.029009 1.127684 TDRD6 16730 38 7.251644 7.538249 0.000306 0.029009 1.127684 SLC25A27 0 39 7.136366 7.538511 0.000404 0.029316 1.166392 SLC25A27 0 40 7.136366 7.538511 0.000404 0.029316 1.166392 TDRD6 0 41 7.136366 7.538511 0.000404 0.029316 1.166392 CYP39A1 0 42 7.181158 7.332966 0.000203 0.027504 1.103727 MPP6 276617 43 7.181158 7.332966 0.000203 0.027504 1.103727 NPY 0 44 7.181158 7.332966 0.000203 0.027504 1.103727 STK31 198122 45 7.344255 7.590757 0.000238 0.02764 1.117055 OR1N1 0 46 7.344255 7.590757 0.000238 0.02764 1.117055 OR1J1 0 47 7.344255 7.590757 0.000238 0.02764 1.117055 OR1J4 0 48 7.344255 7.590757 0.000238 0.02764 1.117055 OR1J2 0 Table 4(a) Probe T1 T2 1 Hg38_11_2141386_2143749_2260699_2266281_RR 9.441793 9.601434 2 Hg38_11_2141386_2143749_2260699_2266281_RR 9.441793 9.601434 3 Hg38_11_2141386_2143749_2260699_2266281_RR 9.441793 9.601434 4 Hg38_11_2141386_2143749_2260699_2266281_RR 9.441793 9.601434 5 Hg38_11_2260699_2266281_2384108_2395301_RF 9.685228 9.814937 6 Hg38_11_2260699_2266281_2384108_2395301_RF 9.685228 9.814937 7 Hg38_11_2260699_2266281_2384108_2395301_RF 9.685228 9.814937 8 Hg38_11_2260699_2266281_2384108_2395301_RF 9.685228 9.814937 9 Hg38_14_106725269_106729795_106850203_106858291_FF 9.012123 9.175428 10 Hg38_14_106725269_106729795_106850203_106858291_FF 9.012123 9.175428 11 Hg38_14_106725269_106729795_106850203_106858291_FF 9.012123 9.175428 12 Hg38_15_46728465_46737403_46854404_46864052_RR 9.264579 9.357902 13 Hg38_15_46728465_46737403_46854404_46864052_RR 9.264579 9.357902 14 Hg38_15_46728465_46737403_46854404_46864052_RR 9.264579 9.357902 15 Hg38_2_99925097_99931434_99971736_99980228_FF 9.178026 9.322698 16 Hg38_2_99925097_99931434_99971736_99980228_FF 9.178026 9.322698 17 Hg38_2_99925097_99931434_99971736_99980228_FF 9.178026 9.322698 18 Hg38_3_89855596_89862325_89997363_90005062_FR 8.971998 9.122944 19 Hg38_3_89855596_89862325_89997363_90005062_FR 8.971998 9.122944 20 Hg38_3_89855596_89862325_89997363_90005062_FR 8.971998 9.122944 21 Hg38_4_758368_762283_948250_949561_RR 9.384273 9.662405 22 Hg38_4_758368_762283_948250_949561_RR 9.384273 9.662405 23 Hg38_4_758368_762283_948250_949561_RR 9.384273 9.662405 24 Hg38_4_758368_762283_948250_949561_RR 9.384273 9.662405 25 Hg38_5_2962609_2965308_3053037_3058791_FR 9.738435 10.05391 26 Hg38_5_2962609_2965308_3053037_3058791_FR 9.738435 10.05391 27 Hg38_5_2962609_2965308_3053037_3058791_FR 9.738435 10.05391 28 Hg38_6_121448828_121451040_121622160_121624541_RF 9.24655 9.381436 29 Hg38_6_121448828_121451040_121622160_121624541_RF 9.24655 9.381436 30 Hg38_6_121448828_121451040_121622160_121624541_RF 9.24655 9.381436 31 Hg38_X_103336904_103343604_103460339_103463611_FR 9.518492 9.682915 32 Hg38_X_103336904_103343604_103460339_103463611_FR 9.518492 9.682915 33 Hg38_X_103336904_103343604_103460339_103463611_FR 9.518492 9.682915 34 Hg38_X_154724525_154732048_154837676_154846662_FF 8.998618 9.183944 35 Hg38_X_154724525_154732048_154837676_154846662_FF 8.998618 9.183944 36 Hg38_X_154724525_154732048_154837676_154846662_FF 8.998618 9.183944 37 Hg38_X_154724525_154732048_154837676_154846662_FF 8.998618 9.183944 38 Hg38_X_154724525_154732048_154837676_154846662_FF 8.998618 9.183944 39 Hg38_X_26183933_26198528_26227930_26234595_RF 9.17651 9.350828 40 Hg38_X_26183933_26198528_26227930_26234595_RF 9.17651 9.350828 41 Hg38_X_26183933_26198528_26227930_26234595_RF 9.17651 9.350828 42 Hg38_X_93541845_93549543_93687706_93694372_RR 9.351559 9.559729 43 Hg38_X_93541845_93549543_93687706_93694372_RR 9.351559 9.559729 44 Hg38_X_93541845_93549543_93687706_93694372_RR 9.351559 9.559729 45 Hg38_X_93541845_93549543_93710465_93719889_RR 9.3362 9.453322 46 Hg38_X_93541845_93549543_93710465_93719889_RR 9.3362 9.453322 47 Hg38_X_93541845_93549543_93710465_93719889_RR 9.3362 9.453322 Table 4(b) T3 T4 P.value adj.P.Val FC gene distance 1 9.802428 9.841616 0.000652 0.032678 1.10194 INS-IGF2 0 2 9.802428 9.841616 0.000652 0.032678 1.10194 TH 0 3 9.802428 9.841616 0.000652 0.032678 1.10194 IGF2 0 4 9.802428 9.841616 0.000652 0.032678 1.10194 INS 0 5 10.04126 10.06985 0.000898 0.034857 1.100393 C11orf21 0 6 10.04126 10.06985 0.000898 0.034857 1.100393 ASCL2 0 7 10.04126 10.06985 0.000898 0.034857 1.100393 TSPAN32 0 8 10.04126 10.06985 0.000898 0.034857 1.100393 CD81 0 9 9.231112 9.484153 0.000622 0.032245 1.107401 C14orf80 1225695 10 9.231112 9.484153 0.000622 0.032245 1.107401 CRIP1 1233003 11 9.231112 9.484153 0.000622 0.032245 1.107401 TMEM121 1195068 12 9.682958 9.786836 0.000331 0.029178 1.140118 SEMA6D 320050 13 9.682958 9.786836 0.000331 0.029178 1.140118 SQRDL 1037172 14 9.682958 9.786836 0.000331 0.029178 1.140118 FKSG62 269601 15 9.417367 9.616815 0.000229 0.027504 1.102748 AFF3 0 16 9.417367 9.616815 0.000229 0.027504 1.102748 CHST10 411633 17 9.417367 9.616815 0.000229 0.027504 1.102748 LONRF2 293064 18 9.242792 9.626748 0.000544 0.031361 1.155414 EPHA3 373463 19 9.242792 9.626748 0.000544 0.031361 1.155414 C3orf38 1686868 20 9.242792 9.626748 0.000544 0.031361 1.155414 CGGBP1 1705712 21 9.916898 10.05348 5.06E-05 0.027504 1.169758 TMEM175 0 22 9.916898 10.05348 5.06E-05 0.027504 1.169758 CPLX1 0 23 9.916898 10.05348 5.06E-05 0.027504 1.169758 PCGF3 0 24 9.916898 10.05348 5.06E-05 0.027504 1.169758 GAK 0 25 10.0624 10.49839 0.000993 0.035439 1.171889 IRX2 210948 26 10.0624 10.49839 0.000993 0.035439 1.171889 C5orf38 207213 27 10.0624 10.49839 0.000993 0.035439 1.171889 IRX1 537264 28 9.467759 9.800257 0.000849 0.034375 1.128764 GJA1 0 29 9.467759 9.800257 0.000849 0.034375 1.128764 HSF2 775006 30 9.467759 9.800257 0.000849 0.034375 1.128764 TBC1D32 114084 31 9.744542 9.981715 0.000487 0.030389 1.10583 TCEAL7 4579 32 9.744542 9.981715 0.000487 0.030389 1.10583 NGFRAP1 0 33 9.744542 9.981715 0.000487 0.030389 1.10583 WBP5 0 34 9.227019 9.506965 0.000747 0.033519 1.114821 MPP1 0 35 9.227019 9.506965 0.000747 0.033519 1.114821 SMIM9 0 36 9.227019 9.506965 0.000747 0.033519 1.114821 DKC1 0 37 9.227019 9.506965 0.000747 0.033519 1.114821 F8 0 38 9.227019 9.506965 0.000747 0.033519 1.114821 GAB3 0 39 9.409619 9.646814 0.000468 0.030335 1.107242 MAGEB18 43199 40 9.409619 9.646814 0.000468 0.030335 1.107242 MAGEB5 0 41 9.409619 9.646814 0.000468 0.030335 1.107242 MAGEB6 0 42 9.654398 9.883795 0.000131 0.027504 1.124386 NAP1L3 0 43 9.654398 9.883795 0.000131 0.027504 1.124386 PCDH11X 918616 44 9.654398 9.883795 0.000131 0.027504 1.124386 FAM133A 0 45 9.561089 9.781729 0.000319 0.029021 1.105298 PCDH11X 918616 46 9.561089 9.781729 0.000319 0.029021 1.105298 NAP1L3 0 47 9.561089 9.781729 0.000319 0.029021 1.105298 FAM133A 0 Table 5(a) Probe T1 T2 1 Hg38_1_222203909_222219735_222339982_222352017_FF 9.993815 10.18577 2 Hg38_1_222203909_222219735_222339982_222352017_FF 9.993815 10.18577 3 Hg38_1_222203909_222219735_222339982_222352017_FF 9.993815 10.18577 4 Hg38_1_222230209_222242015_222339982_222352017_FF 10.66652 10.84691 5 Hg38_1_222230209_222242015_222339982_222352017_FF 10.66652 10.84691 6 Hg38_1_222230209_222242015_222339982_222352017_FF 10.66652 10.84691 7 Hg38_11_48823095_48832082_49035844_49042176_FF 10.04196 10.17918 8 Hg38_11_48823095_48832082_49035844_49042176_FF 10.04196 10.17918 9 Hg38_11_48823095_48832082_49035844_49042176_FF 10.04196 10.17918 10 Hg38_4_758368_762283_870784_876871_RR 10.40468 10.62812 11 Hg38_4_758368_762283_870784_876871_RR 10.40468 10.62812 12 Hg38_4_758368_762283_870784_876871_RR 10.40468 10.62812 13 Hg38_4_758368_762283_934404_935467_RR 10.28576 10.57328 14 Hg38_4_758368_762283_934404_935467_RR 10.28576 10.57328 15 Hg38_4_758368_762283_934404_935467_RR 10.28576 10.57328 16 Hg38_4_758368_762283_934404_935467_RR 10.28576 10.57328 17 Hg38_X_71631628_71634196_71764753_71768302_RR 10.03252 10.26123 18 Hg38_X_71631628_71634196_71764753_71768302_RR 10.03252 10.26123 19 Hg38_X_71631628_71634196_71764753_71768302_RR 10.03252 10.26123 Table 5(b) T3 T4 P.value adj.P.Val FC gene distance 1 10.24081 10.55464 0.000618 0.032219 1.127988 HHIPL2 170242 2 10.24081 10.55464 0.000618 0.032219 1.127988 TAF1A 205886 3 10.24081 10.55464 0.000618 0.032219 1.127988 MIA3 266070 4 10.88687 11.19676 0.000987 0.035439 1.119664 TAF1A 205886 5 10.88687 11.19676 0.000987 0.035439 1.119664 MIA3 266070 6 10.88687 11.19676 0.000987 0.035439 1.119664 HHIPL2 170242 7 10.24731 10.55231 0.000961 0.035359 1.117224 FOLH1 104460 8 10.24731 10.55231 0.000961 0.035359 1.117224 TRIM49B 0 9 10.24731 10.55231 0.000961 0.035359 1.117224 TRIM64C 11539 10 10.80177 10.83972 0.000929 0.034971 1.107936 PCGF3 0 11 10.80177 10.83972 0.000929 0.034971 1.107936 CPLX1 0 12 10.80177 10.83972 0.000929 0.034971 1.107936 GAK 0 13 10.74383 10.83067 0.00041 0.029541 1.133298 PCGF3 0 14 10.74383 10.83067 0.00041 0.029541 1.133298 CPLX1 0 15 10.74383 10.83067 0.00041 0.029541 1.133298 TMEM175 0 16 10.74383 10.83067 0.00041 0.029541 1.133298 GAK 0 17 10.30592 10.49261 0.000606 0.032219 1.103812 CXorf49 0 18 10.30592 10.49261 0.000606 0.032219 1.103812 CXCR3 13112 19 10.30592 10.49261 0.000606 0.032219 1.103812 CXorf49B 0 Table 6(a) probe T1 T2 1 Hg38_1_104155142_104164136_104212693_104216981_RF 11.83159849 11.63796539 2 Hg38_1_104155142_104164136_104212693_104216981_RF 11.83159849 11.63796539 3 Hg38_1_104155142_104164136_104212693_104216981_RF 11.83159849 11.63796539 4 Hg38_1_116615072_116622117_116783136_116789525_FR 11.41869735 11.24095168 5 Hg38_1_116615072_116622117_116783136_116789525_FR 11.41869735 11.24095168 6 Hg38_1_116615072_116622117_116783136_116789525_FR 11.41869735 11.24095168 7 Hg38_1_221903702_221909298_222050352_222059866_FR 11.74336896 11.61153981 8 Hg38_1_221903702_221909298_222050352_222059866_FR 11.74336896 11.61153981 9 Hg38_1_221903702_221909298_222050352_222059866_FR 11.74336896 11.61153981 10 Hg38_1_222050352_222059866_222203909_222219735_RF 11.77976418 11.63383537 11 Hg38_1_222050352_222059866_222203909_222219735_RF 11.77976418 11.63383537 12 Hg38_1_222050352_222059866_222203909_222219735_RF 11.77976418 11.63383537 13 Hg38_1_224101266_224103698_224169016_224176732_RR 12.35864248 12.26926242 14 Hg38_1_224101266_224103698_224169016_224176732_RR 12.35864248 12.26926242 15 Hg38_1_224101266_224103698_224169016_224176732_RR 12.35864248 12.26926242 16 Hg38_1_248830529_248837451_248861922_248867160_RR 11.96648603 11.82468129 17 Hg38_1_248830529_248837451_248861922_248867160_RR 11.96648603 11.82468129 18 Hg38_1_248830529_248837451_248861922_248867160_RR 11.96648603 11.82468129 19 Hg38_1_248830529_248837451_248893226_248905913_RR 11.59818247 11.50101716 20 Hg38_1_248830529_248837451_248893226_248905913_RR 11.59818247 11.50101716 21 Hg38_1_248830529_248837451_248893226_248905913_RR 11.59818247 11.50101716 22 Hg38_1_248830529_248837451_248923161_248926101_RR 12.37658209 12.26318089 23 Hg38_1_248830529_248837451_248923161_248926101_RR 12.37658209 12.26318089 24 Hg38_1_248830529_248837451_248923161_248926101_RR 12.37658209 12.26318089 25 Hg38_1_40388458_40392895_40507867_40509841_RF 12.15520831 12.02563624 26 Hg38_1_40388458_40392895_40507867_40509841_RF 12.15520831 12.02563624 27 Hg38_1_40388458_40392895_40507867_40509841_RF 12.15520831 12.02563624 28 Hg38_1_40388458_40392895_40507867_40509841_RF 12.15520831 12.02563624 29 Hg38_1_54185261_54188980_54222118_54228307_RF 11.5249825 11.31326493 30 Hg38_1_54185261_54188980_54222118_54228307_RF 11.5249825 11.31326493 31 Hg38_1_54185261_54188980_54222118_54228307_RF 11.5249825 11.31326493 32 Hg38_1_54185261_54188980_54222118_54228307_RF 11.5249825 11.31326493 33 Hg38_1_54222118_54228307_54325760_54335640_FR 11.48829019 11.29435221 34 Hg38_1_54222118_54228307_54325760_54335640_FR 11.48829019 11.29435221 35 Hg38_1_54222118_54228307_54325760_54335640_FR 11.48829019 11.29435221 36 Hg38_1_54222118_54228307_54339710_54344485_FF 11.41904458 11.17312422 37 Hg38_1_54222118_54228307_54339710_54344485_FF 11.41904458 11.17312422 38 Hg38_1_54222118_54228307_54339710_54344485_FF 11.41904458 11.17312422 39 Hg38_1_54222118_54228307_54371664_54378700_FF 11.25235668 11.03219636 40 Hg38_1_54222118_54228307_54371664_54378700_FF 11.25235668 11.03219636 41 Hg38_1_54222118_54228307_54371664_54378700_FF 11.25235668 11.03219636 42 Hg38_1_89127656_89129856_89162605_89170611_RF 11.99326878 11.81911717 Hg38_1_89127656_89129856_89162605_89170611_RF 11.99326878 11.81911717 Hg38_1_89127656_89129856_89162605_89170611_RF 11.99326878 11.81911717 Hg38_10_122854617_122860352_123013681_123018052_FR 12.25293509 12.08767904 Hg38_10_122854617_122860352_123013681_123018052_FR 12.25293509 12.08767904 Hg38_10_122854617_122860352_123013681_123018052_FR 12.25293509 12.08767904 Hg38_10_122854617_122860352_123013681_123018052_FR 12.25293509 12.08767904 Hg38_10_122854617_122860352_123013681_123018052_FR 12.25293509 12.08767904 Hg38_10_122854617_122860352_123013681_123018052_FR 12.25293509 12.08767904 Hg38_10_122860352_122866811_123013681_123018052_FR 12.39772986 12.2701345 Hg38_10_122860352_122866811_123013681_123018052_FR 12.39772986 12.2701345 Hg38_10_122860352_122866811_123013681_123018052_FR 12.39772986 12.2701345 Hg38_10_122860352_122866811_123013681_123018052_FR 12.39772986 12.2701345 Hg38_10_122860352_122866811_123013681_123018052_FR 12.39772986 12.2701345 Hg38_10_122860352_122866811_123013681_123018052_FR 12.39772986 12.2701345 Hg38_10_122909176_122914508_123013681_123018052_R 12.25191403 12.14815894 R Hg38_10_122909176_122914508_123013681_123018052_R 12.25191403 12.14815894 R Hg38_10_122909176_122914508_123013681_123018052_R 12.25191403 12.14815894 R Hg38_10_122909176_122914508_123013681_123018052_R 12.25191403 12.14815894 R Hg38_10_122909176_122914508_123013681_123018052_R 12.25191403 12.14815894 R Hg38_10_125739028_125742650_125964956_125970091_RF 11.7311966 11.67061028 Hg38_10_125739028_125742650_125964956_125970091_RF 11.7311966 11.67061028 Hg38_10_125739028_125742650_125964956_125970091_RF 11.7311966 11.67061028 Hg38_10_125739028_125742650_125964956_125970091_RF 11.7311966 11.67061028 Hg38_10_125739028_125742650_125964956_125970091_RF 11.7311966 11.67061028 Hg38_10_125739028_125742650_125964956_125970091_RF 11.7311966 11.67061028 Hg38_10_125755866_125759931_125964956_125970091_RF 11.71036131 11.59360031 Hg38_10_125755866_125759931_125964956_125970091_RF 11.71036131 11.59360031 Hg38_10_125755866_125759931_125964956_125970091_RF 11.71036131 11.59360031 Hg38_10_125755866_125759931_125964956_125970091_RF 11.71036131 11.59360031 Hg38_10_125755866_125759931_125964956_125970091_RF 11.71036131 11.59360031 Hg38_10_125755866_125759931_125964956_125970091_RF 11.71036131 11.59360031 Hg38_10_125856887_125860347_125964956_125970091_RF 12.07446249 11.9916509 Hg38_10_125856887_125860347_125964956_125970091_RF 12.07446249 11.9916509 Hg38_10_125856887_125860347_125964956_125970091_RF 12.07446249 11.9916509 Hg38_10_125964956_125970091_126019312_126025693_FR 11.59476066 11.50907661 Hg38_10_125964956_125970091_126019312_126025693_FR 11.59476066 11.50907661 Hg38_10_125964956_125970091_126019312_126025693_FR 11.59476066 11.50907661 Hg38_10_125964956_125970091_126071909_126076479_FF 11.47325121 11.3527636 Hg38_10_125964956_125970091_126071909_126076479_FF 11.47325121 11.3527636 Hg38_10_125964956_125970091_126071909_126076479_FF 11.47325121 11.3527636 Hg38_10_4844692_4851605_4970944_4976417_RR 11.8482821 11.67436535 Hg38_10_4844692_4851605_4970944_4976417_RR 11.8482821 11.67436535 Hg38_10_4844692_4851605_4970944_4976417_RR 11.8482821 11.67436535 Hg38_10_4844692_4851605_5078973_5085504_RR 12.12050857 11.94464935 Hg38_10_4844692_4851605_5078973_5085504_RR 12.12050857 11.94464935 Hg38_10_4844692_4851605_5078973_5085504_RR 12.12050857 11.94464935 Hg38_10_4844692_4851605_5078973_5085504_RR 12.12050857 11.94464935 Hg38_10_5049934_5052591_5142013_5157492_FF 12.24747655 12.04351486 Hg38_10_5049934_5052591_5142013_5157492_FF 12.24747655 12.04351486 Hg38_10_5049934_5052591_5142013_5157492_FF 12.24747655 12.04351486 Hg38_10_59744659_59748251_59957628_59964162_RR 11.83782389 11.77068507 Hg38_10_59744659_59748251_59957628_59964162_RR 11.83782389 11.77068507 Hg38_10_59744659_59748251_59957628_59964162_RR 11.83782389 11.77068507 Hg38_10_73696237_73697710_73766695_73769440_FR 11.13973763 11.00220329 Hg38_10_73696237_73697710_73766695_73769440_FR 11.13973763 11.00220329 Hg38_10_73696237_73697710_73766695_73769440_FR 11.13973763 11.00220329 Hg38_10_73696237_73697710_73818930_73822387_FR 11.44078637 11.27528914 Hg38_10_73696237_73697710_73818930_73822387_FR 11.44078637 11.27528914 Hg38_10_73696237_73697710_73818930_73822387_FR 11.44078637 11.27528914 Hg38_10_73696237_73697710_73818930_73822387_FR 11.44078637 11.27528914 Hg38_10_73696237_73697710_73818930_73822387_FR 11.44078637 11.27528914 Hg38_10_73696237_73697710_73818930_73822387_FR 11.44078637 11.27528914 Hg38_10_73696237_73697710_73818930_73822387_FR 11.44078637 11.27528914 Hg38_10_73696237_73697710_73818930_73822387_FR 11.44078637 11.27528914 Hg38_10_73696237_73697710_73900120_73903402_FF 11.30010442 11.13726602 Hg38_10_73696237_73697710_73900120_73903402_FF 11.30010442 11.13726602 Hg38_10_73696237_73697710_73900120_73903402_FF 11.30010442 11.13726602 Hg38_10_73696237_73697710_73900120_73903402_FF 11.30010442 11.13726602 Hg38_10_73696237_73697710_73900120_73903402_FF 11.30010442 11.13726602 Hg38_10_73696237_73697710_73900120_73903402_FF 11.30010442 11.13726602 Hg38_10_73696237_73697710_73900120_73903402_FF 11.30010442 11.13726602 Hg38_10_73696237_73697710_73900120_73903402_FF 11.30010442 11.13726602 Hg38_11_3450444_3458552_3577328_3580747_RF 11.60529337 11.45517262 Hg38_11_3450444_3458552_3577328_3580747_RF 11.60529337 11.45517262 Hg38_11_3450444_3458552_3577328_3580747_RF 11.60529337 11.45517262 Hg38_11_3450444_3458552_3580747_3586353_FR 11.35488314 11.25989582 Hg38_11_3450444_3458552_3580747_3586353_FR 11.35488314 11.25989582 Hg38_11_3450444_3458552_3580747_3586353_FR 11.35488314 11.25989582 Hg38_11_3450444_3458552_3580747_3586353_RR 11.68013263 11.49060445 Hg38_11_3450444_3458552_3580747_3586353_RR 11.68013263 11.49060445 Hg38_11_3450444_3458552_3580747_3586353_RR 11.68013263 11.49060445 Hg38_11_3577328_3580747_3653084_3655610_FF 11.678566 11.55161637 Hg38_11_3577328_3580747_3653084_3655610_FF 11.678566 11.55161637 Hg38_11_3577328_3580747_3653084_3655610_FF 11.678566 11.55161637 Hg38_11_3580747_3586353_3665662_3666983_RR 12.078785 11.99467901 Hg38_11_3580747_3586353_3665662_3666983_RR 12.078785 11.99467901 Hg38_11_3580747_3586353_3665662_3666983_RR 12.078785 11.99467901 Hg38_11_50184040_50189728_50360253_50367557_RR 11.43625991 11.23370097 Hg38_11_50184040_50189728_50360253_50367557_RR 11.43625991 11.23370097 Hg38_11_50184040_50189728_50360253_50367557_RR 11.43625991 11.23370097 Hg38_11_60714374_60719559_60808823_60817803_RR 11.48022006 11.43963941 Hg38_11_60714374_60719559_60808823_60817803_RR 11.48022006 11.43963941 Hg38_11_60714374_60719559_60808823_60817803_RR 11.48022006 11.43963941 Hg38_11_60714374_60719559_60808823_60817803_RR 11.48022006 11.43963941 Hg38_11_67949565_67955293_67997396_67999798_FR 11.61503277 11.4799874 Hg38_11_67949565_67955293_67997396_67999798_FR 11.61503277 11.4799874 Hg38_11_67949565_67955293_67997396_67999798_FR 11.61503277 11.4799874 Hg38_11_67949565_67955293_68006426_68009576_FR 11.47052725 11.3279913 Hg38_11_67949565_67955293_68006426_68009576_FR 11.47052725 11.3279913 Hg38_11_67949565_67955293_68006426_68009576_FR 11.47052725 11.3279913 Hg38_11_72910378_72917595_73013017_73021302_RR 11.34862757 11.19269634 Hg38_11_72910378_72917595_73013017_73021302_RR 11.34862757 11.19269634 Hg38_11_72910378_72917595_73013017_73021302_RR 11.34862757 11.19269634 Hg38_11_84226883_84235324_84301453_84308327_FF 11.95932056 11.813527 Hg38_11_84226883_84235324_84301453_84308327_FF 11.95932056 11.813527 Hg38_11_84226883_84235324_84301453_84308327_FF 11.95932056 11.813527 Hg38_12_102081838_102089174_102229355_102236025_FF 11.83997238 11.69323804 Hg38_12_102081838_102089174_102229355_102236025_FF 11.83997238 11.69323804 Hg38_12_102081838_102089174_102229355_102236025_FF 11.83997238 11.69323804 Hg38_12_40352926_40356798_40447898_40455540_RF 12.02154492 11.94138532 Hg38_12_40352926_40356798_40447898_40455540_RF 12.02154492 11.94138532 Hg38_12_40352926_40356798_40447898_40455540_RF 12.02154492 11.94138532 Hg38_12_55418204_55429756_55645011_55648219_RF 11.84797697 11.76903349 Hg38_12_55418204_55429756_55645011_55648219_RF 11.84797697 11.76903349 Hg38_12_55418204_55429756_55645011_55648219_RF 11.84797697 11.76903349 Hg38_12_55418204_55429756_55645011_55648219_RF 11.84797697 11.76903349 Hg38_12_55418204_55429756_55645011_55648219_RF 11.84797697 11.76903349 Hg38_12_55418204_55429756_55645011_55648219_RF 11.84797697 11.76903349 Hg38_12_55418204_55429756_55645011_55648219_RF 11.84797697 11.76903349 Hg38_12_55491176_55499149_55645011_55648219_RF 11.84339425 11.76364375 Hg38_12_55491176_55499149_55645011_55648219_RF 11.84339425 11.76364375 Hg38_12_55491176_55499149_55645011_55648219_RF 11.84339425 11.76364375 Hg38_12_55491176_55499149_55645011_55648219_RF 11.84339425 11.76364375 Hg38_12_55580879_55590428_55645011_55648219_RF 11.86104178 11.76335598 Hg38_12_55580879_55590428_55645011_55648219_RF 11.86104178 11.76335598 Hg38_12_55580879_55590428_55645011_55648219_RF 11.86104178 11.76335598 Hg38_12_55645011_55648219_55682515_55683887_FF 11.81902545 11.71574422 Hg38_12_55645011_55648219_55682515_55683887_FF 11.81902545 11.71574422 Hg38_12_55645011_55648219_55682515_55683887_FF 11.81902545 11.71574422 Hg38_12_55645011_55648219_55719534_55724411_FR 12.06334482 12.01456029 Hg38_12_55645011_55648219_55719534_55724411_FR 12.06334482 12.01456029 Hg38_12_55645011_55648219_55719534_55724411_FR 12.06334482 12.01456029 Hg38_12_55645011_55648219_55719534_55724411_FR 12.06334482 12.01456029 Hg38_12_55645011_55648219_55719534_55724411_FR 12.06334482 12.01456029 Hg38_12_5718516_5726533_5889068_5900534_RR 12.11950036 11.92675783 Hg38_12_5718516_5726533_5889068_5900534_RR 12.11950036 11.92675783 Hg38_12_5718516_5726533_5889068_5900534_RR 12.11950036 11.92675783 Hg38_13_112527447_112531388_112676877_112678379_RF 11.5607585 11.43807609 Hg38_13_112527447_112531388_112676877_112678379_RF 11.5607585 11.43807609 Hg38_13_112527447_112531388_112676877_112678379_RF 11.5607585 11.43807609 Hg38_13_112592963_112600705_112676877_112678379_RF 11.6473254 11.54587618 Hg38_13_112592963_112600705_112676877_112678379_RF 11.6473254 11.54587618 Hg38_13_112592963_112600705_112676877_112678379_RF 11.6473254 11.54587618 Hg38_13_112606347_112610878_112676877_112678379_RF 11.94421151 11.81344522 Hg38_13_112606347_112610878_112676877_112678379_RF 11.94421151 11.81344522 Hg38_13_112606347_112610878_112676877_112678379_RF 11.94421151 11.81344522 Hg38_13_112676877_112678379_112692201_112697793_FR 12.00209894 11.87277762 Hg38_13_112676877_112678379_112692201_112697793_FR 12.00209894 11.87277762 Hg38_13_112676877_112678379_112692201_112697793_FR 12.00209894 11.87277762 Hg38_13_112676877_112678379_112795997_112800854_FF 11.5341372 11.49056027 Hg38_13_112676877_112678379_112795997_112800854_FF 11.5341372 11.49056027 Hg38_13_112676877_112678379_112795997_112800854_FF 11.5341372 11.49056027 Hg38_13_114317775_114320752_114350972_114353704_RF 11.96879705 11.81184767 Hg38_13_114317775_114320752_114350972_114353704_RF 11.96879705 11.81184767 Hg38_13_114317775_114320752_114350972_114353704_RF 11.96879705 11.81184767 Hg38_13_52818384_52826312_53047390_53050193_RR 12.12518457 12.02103606 Hg38_13_52818384_52826312_53047390_53050193_RR 12.12518457 12.02103606 Hg38_13_52818384_52826312_53047390_53050193_RR 12.12518457 12.02103606 Hg38_13_81248995_81256836_81333759_81340546_FF 11.51563903 11.40941387 Hg38_13_81248995_81256836_81333759_81340546_FF 11.51563903 11.40941387 Hg38_13_81248995_81256836_81333759_81340546_FF 11.51563903 11.40941387 Hg38_13_81483789_81491532_81683535_81690364_RF 11.44819467 11.30282664 Hg38_13_81483789_81491532_81683535_81690364_RF 11.44819467 11.30282664 Hg38_13_81483789_81491532_81683535_81690364_RF 11.44819467 11.30282664 Hg38_13_81683535_81690364_81728461_81739837_FR 11.44306932 11.33560566 Hg38_13_81683535_81690364_81728461_81739837_FR 11.44306932 11.33560566 Hg38_13_81683535_81690364_81728461_81739837_FR 11.44306932 11.33560566 Hg38_14_106324350_106329828_106364678_106372506_R 11.19954298 11.03381559 R Hg38_14_106324350_106329828_106364678_106372506_R 11.19954298 11.03381559 R Hg38_14_106324350_106329828_106364678_106372506_R 11.19954298 11.03381559 R Hg38_14_106349379_106355290_106408565_106421805_RF 11.55849536 11.33392926 Hg38_14_106349379_106355290_106408565_106421805_RF 11.55849536 11.33392926 Hg38_14_106349379_106355290_106408565_106421805_RF 11.55849536 11.33392926 Hg38_14_106349379_106355290_106489330_106496086_R 11.62600266 11.37298691 R Hg38_14_106349379_106355290_106489330_106496086_R 11.62600266 11.37298691 R Hg38_14_106349379_106355290_106489330_106496086_R 11.62600266 11.37298691 R Hg38_14_18901894_18910303_18921766_18924508_FR 11.96255627 11.70994461 Hg38_14_18901894_18910303_18921766_18924508_FR 11.96255627 11.70994461 Hg38_14_18901894_18910303_18921766_18924508_FR 11.96255627 11.70994461 Hg38_14_19244587_19255966_19477438_19480180_FF 12.13210094 11.91432233 Hg38_14_19244587_19255966_19477438_19480180_FF 12.13210094 11.91432233 Hg38_14_19244587_19255966_19477438_19480180_FF 12.13210094 11.91432233 Hg38_14_31453022_31454581_31550652_31559993_RF 12.24621117 12.17715435 Hg38_14_31453022_31454581_31550652_31559993_RF 12.24621117 12.17715435 Hg38_14_31453022_31454581_31550652_31559993_RF 12.24621117 12.17715435 Hg38_14_31453022_31454581_31550652_31559993_RF 12.24621117 12.17715435 Hg38_14_31550652_31559993_31759063_31776452_FF 11.79520279 11.65337132 Hg38_14_31550652_31559993_31759063_31776452_FF 11.79520279 11.65337132 Hg38_14_31550652_31559993_31759063_31776452_FF 11.79520279 11.65337132 Hg38_14_50956408_50958668_51002355_51010487_RF 12.22352703 12.12267215 Hg38_14_50956408_50958668_51002355_51010487_RF 12.22352703 12.12267215 Hg38_14_50956408_50958668_51002355_51010487_RF 12.22352703 12.12267215 Hg38_14_57054086_57056432_57239308_57248911_FF 11.69602239 11.5527343 Hg38_14_57054086_57056432_57239308_57248911_FF 11.69602239 11.5527343 Hg38_14_57054086_57056432_57239308_57248911_FF 11.69602239 11.5527343 Hg38_14_57054086_57056432_57239308_57248911_FR 12.23635312 12.01172566 Hg38_14_57054086_57056432_57239308_57248911_FR 12.23635312 12.01172566 Hg38_14_57054086_57056432_57239308_57248911_FR 12.23635312 12.01172566 Hg38_14_69903453_69913429_70041213_70052977_RR 11.72550236 11.65108041 Hg38_14_69903453_69913429_70041213_70052977_RR 11.72550236 11.65108041 Hg38_14_69903453_69913429_70041213_70052977_RR 11.72550236 11.65108041 Hg38_14_69903453_69913429_70091751_70100413_RR 11.71593642 11.63405484 Hg38_14_69903453_69913429_70091751_70100413_RR 11.71593642 11.63405484 Hg38_14_69903453_69913429_70091751_70100413_RR 11.71593642 11.63405484 Hg38_15_74355324_74364387_74479961_74481973_RR 12.3486017 12.16437598 Hg38_15_74355324_74364387_74479961_74481973_RR 12.3486017 12.16437598 Hg38_15_74355324_74364387_74479961_74481973_RR 12.3486017 12.16437598 Hg38_16_76378053_76381856_76493981_76500024_RF 11.63587503 11.48987319 Hg38_16_76378053_76381856_76493981_76500024_RF 11.63587503 11.48987319 Hg38_16_76378053_76381856_76493981_76500024_RF 11.63587503 11.48987319 Hg38_16_76493981_76500024_76579000_76588102_FF 11.59081806 11.49824559 Hg38_16_76493981_76500024_76579000_76588102_FF 11.59081806 11.49824559 Hg38_16_76493981_76500024_76579000_76588102_FF 11.59081806 11.49824559 Hg38_16_76493981_76500024_76579000_76588102_FR 11.65492606 11.57645355 Hg38_16_76493981_76500024_76579000_76588102_FR 11.65492606 11.57645355 Hg38_16_76493981_76500024_76579000_76588102_FR 11.65492606 11.57645355 Hg38_17_76173082_76176469_76254919_76257305_FF 11.8192954 11.69620113 Hg38_17_76173082_76176469_76254919_76257305_FF 11.8192954 11.69620113 Hg38_17_76173082_76176469_76254919_76257305_FF 11.8192954 11.69620113 Hg38_17_81171713_81177668_81345804_81351809_FF 12.10852497 11.9887456 Hg38_17_81171713_81177668_81345804_81351809_FF 12.10852497 11.9887456 Hg38_17_81171713_81177668_81345804_81351809_FF 12.10852497 11.9887456 Hg38_17_81171713_81177668_81345804_81351809_FF 12.10852497 11.9887456 Hg38_17_81171713_81177668_81345804_81351809_FF 12.10852497 11.9887456 Hg38_18_11344989_11351849_11390098_11394026_RR 11.63766673 11.5363351 Hg38_18_11344989_11351849_11390098_11394026_RR 11.63766673 11.5363351 Hg38_18_11344989_11351849_11390098_11394026_RR 11.63766673 11.5363351 Hg38_18_11344989_11351849_11453118_11456157_RR 11.80124695 11.73015417 Hg38_18_11344989_11351849_11453118_11456157_RR 11.80124695 11.73015417 Hg38_18_11344989_11351849_11453118_11456157_RR 11.80124695 11.73015417 Hg38_18_11344989_11351849_11514807_11516972_RR 11.60435976 11.51522124 Hg38_18_11344989_11351849_11514807_11516972_RR 11.60435976 11.51522124 Hg38_18_11344989_11351849_11514807_11516972_RR 11.60435976 11.51522124 Hg38_18_47828482_47832309_47870453_47878010_RR 11.85164262 11.74202107 Hg38_18_47828482_47832309_47870453_47878010_RR 11.85164262 11.74202107 Hg38_18_47828482_47832309_47870453_47878010_RR 11.85164262 11.74202107 Hg38_18_78999053_79004353_79032800_79038868_RF 11.3711321 11.18578171 Hg38_18_78999053_79004353_79032800_79038868_RF 11.3711321 11.18578171 Hg38_18_78999053_79004353_79032800_79038868_RF 11.3711321 11.18578171 Hg38_19_47957709_47959307_47991291_47992532_RR 12.1152126 11.92349845 Hg38_19_47957709_47959307_47991291_47992532_RR 12.1152126 11.92349845 Hg38_19_47957709_47959307_47991291_47992532_RR 12.1152126 11.92349845 Hg38_19_47957709_47959307_48062024_48066608_RR 12.07203084 11.87150716 Hg38_19_47957709_47959307_48062024_48066608_RR 12.07203084 11.87150716 Hg38_19_47957709_47959307_48062024_48066608_RR 12.07203084 11.87150716 Hg38_19_47957709_47959307_48062024_48066608_RR 12.07203084 11.87150716 Hg38_19_8376488_8380214_8399744_8401301_RR 11.93464074 11.78838554 Hg38_19_8376488_8380214_8399744_8401301_RR 11.93464074 11.78838554 Hg38_19_8376488_8380214_8399744_8401301_RR 11.93464074 11.78838554 Hg38_19_8376488_8380214_8478458_8485631_RR 11.17427388 11.08948263 Hg38_19_8376488_8380214_8478458_8485631_RR 11.17427388 11.08948263 Hg38_19_8376488_8380214_8478458_8485631_RR 11.17427388 11.08948263 Hg38_19_8376488_8380214_8478458_8485631_RR 11.17427388 11.08948263 Hg38_19_8376488_8380214_8498669_8501314_RR 11.7151223 11.55762943 Hg38_19_8376488_8380214_8498669_8501314_RR 11.7151223 11.55762943 Hg38_19_8376488_8380214_8498669_8501314_RR 11.7151223 11.55762943 Hg38_19_8376488_8380214_8498669_8501314_RR 11.7151223 11.55762943 Hg38_19_8376488_8380214_8498669_8501314_RR 11.7151223 11.55762943 Hg38_2_189612585_189616295_189758180_189760223_RF 11.77700062 11.70455607 Hg38_2_189612585_189616295_189758180_189760223_RF 11.77700062 11.70455607 Hg38_2_189612585_189616295_189758180_189760223_RF 11.77700062 11.70455607 Hg38_2_189616372_189626360_189758180_189760223_RF 11.84750047 11.77809769 Hg38_2_189616372_189626360_189758180_189760223_RF 11.84750047 11.77809769 Hg38_2_189616372_189626360_189758180_189760223_RF 11.84750047 11.77809769 Hg38_2_189678595_189682809_189758180_189760223_RF 11.80005119 11.72717742 Hg38_2_189678595_189682809_189758180_189760223_RF 11.80005119 11.72717742 Hg38_2_189678595_189682809_189758180_189760223_RF 11.80005119 11.72717742 Hg38_2_189758180_189760223_189815365_189821252_FR 11.65878358 11.56719086 Hg38_2_189758180_189760223_189815365_189821252_FR 11.65878358 11.56719086 Hg38_2_189758180_189760223_189815365_189821252_FR 11.65878358 11.56719086 Hg38_2_189758180_189760223_189815365_189821252_FR 11.65878358 11.56719086 Hg38_2_189758180_189760223_189836739_189843237_FR 11.84416346 11.73361707 Hg38_2_189758180_189760223_189836739_189843237_FR 11.84416346 11.73361707 Hg38_2_189758180_189760223_189836739_189843237_FR 11.84416346 11.73361707 Hg38_2_189758180_189760223_189836739_189843237_FR 11.84416346 11.73361707 Hg38_2_189758180_189760223_189880013_189885169_FF 11.70516382 11.65019685 Hg38_2_189758180_189760223_189880013_189885169_FF 11.70516382 11.65019685 Hg38_2_189758180_189760223_189880013_189885169_FF 11.70516382 11.65019685 Hg38_2_189758180_189760223_189880013_189885169_FF 11.70516382 11.65019685 Hg38_2_189758180_189760223_189880013_189885169_FF 11.70516382 11.65019685 Hg38_2_189758180_189760223_189880013_189885169_FR 11.61986279 11.56713029 Hg38_2_189758180_189760223_189880013_189885169_FR 11.61986279 11.56713029 Hg38_2_189758180_189760223_189880013_189885169_FR 11.61986279 11.56713029 Hg38_2_189758180_189760223_189880013_189885169_FR 11.61986279 11.56713029 Hg38_2_189758180_189760223_189880013_189885169_FR 11.61986279 11.56713029 Hg38_2_189758180_189760223_189885169_189891009_FR 11.72229598 11.6084062 Hg38_2_189758180_189760223_189885169_189891009_FR 11.72229598 11.6084062 Hg38_2_189758180_189760223_189885169_189891009_FR 11.72229598 11.6084062 Hg38_2_189758180_189760223_189885169_189891009_FR 11.72229598 11.6084062 Hg38_2_189758180_189760223_189885169_189891009_FR 11.72229598 11.6084062 Hg38_2_189758180_189760223_189893108_189898781_FF 11.77843309 11.70965679 Hg38_2_189758180_189760223_189893108_189898781_FF 11.77843309 11.70965679 Hg38_2_189758180_189760223_189893108_189898781_FF 11.77843309 11.70965679 Hg38_2_189758180_189760223_189893108_189898781_FF 11.77843309 11.70965679 Hg38_2_189758180_189760223_189893108_189898781_FF 11.77843309 11.70965679 Hg38_2_189758180_189760223_189990006_190006814_FR 12.37147291 12.27639699 Hg38_2_189758180_189760223_189990006_190006814_FR 12.37147291 12.27639699 Hg38_2_189758180_189760223_189990006_190006814_FR 12.37147291 12.27639699 Hg38_2_189758180_189760223_189990006_190006814_FR 12.37147291 12.27639699 Hg38_2_189758180_189760223_189990006_190006814_FR 12.37147291 12.27639699 Hg38_2_189758180_189760223_190020108_190023631_FF 12.04386926 11.96873502 Hg38_2_189758180_189760223_190020108_190023631_FF 12.04386926 11.96873502 Hg38_2_189758180_189760223_190020108_190023631_FF 12.04386926 11.96873502 Hg38_2_189758180_189760223_190020108_190023631_FF 12.04386926 11.96873502 Hg38_2_189758180_189760223_190020108_190023631_FF 12.04386926 11.96873502 Hg38_2_189758180_189760223_190020108_190023631_FR 12.30428883 12.1577478 Hg38_2_189758180_189760223_190020108_190023631_FR 12.30428883 12.1577478 Hg38_2_189758180_189760223_190020108_190023631_FR 12.30428883 12.1577478 Hg38_2_189758180_189760223_190020108_190023631_FR 12.30428883 12.1577478 Hg38_2_189758180_189760223_190020108_190023631_FR 12.30428883 12.1577478 Hg38_2_191409830_191416307_191452307_191456550_RF 11.82110717 11.70693113 Hg38_2_191409830_191416307_191452307_191456550_RF 11.82110717 11.70693113 Hg38_2_191409830_191416307_191452307_191456550_RF 11.82110717 11.70693113 Hg38_2_191434825_191441120_191452307_191456550_RF 11.88920137 11.79582791 Hg38_2_191434825_191441120_191452307_191456550_RF 11.88920137 11.79582791 Hg38_2_191434825_191441120_191452307_191456550_RF 11.88920137 11.79582791 Hg38_2_191452307_191456550_191595606_191604413_FF 11.90016993 11.83004536 Hg38_2_191452307_191456550_191595606_191604413_FF 11.90016993 11.83004536 Hg38_2_191452307_191456550_191595606_191604413_FF 11.90016993 11.83004536 Hg38_2_191452307_191456550_191595606_191604413_FR 11.61945194 11.54283271 Hg38_2_191452307_191456550_191595606_191604413_FR 11.61945194 11.54283271 Hg38_2_191452307_191456550_191595606_191604413_FR 11.61945194 11.54283271 Hg38_2_191452307_191456550_191625507_191633306_FR 11.87827092 11.78430109 Hg38_2_191452307_191456550_191625507_191633306_FR 11.87827092 11.78430109 Hg38_2_191452307_191456550_191625507_191633306_FR 11.87827092 11.78430109 Hg38_2_191452307_191456550_191644639_191651978_FF 11.5126956 11.41421987 Hg38_2_191452307_191456550_191644639_191651978_FF 11.5126956 11.41421987 Hg38_2_191452307_191456550_191644639_191651978_FF 11.5126956 11.41421987 Hg38_2_191452307_191456550_191654091_191662443_FF 11.91075901 11.79271766 Hg38_2_191452307_191456550_191654091_191662443_FF 11.91075901 11.79271766 Hg38_2_191452307_191456550_191654091_191662443_FF 11.91075901 11.79271766 Hg38_2_191452307_191456550_191654091_191662443_FR 11.85770542 11.78898263 Hg38_2_191452307_191456550_191654091_191662443_FR 11.85770542 11.78898263 Hg38_2_191452307_191456550_191654091_191662443_FR 11.85770542 11.78898263 Hg38_2_215158440_215163198_215361328_215366837_FF 11.60785382 11.56632535 Hg38_2_215158440_215163198_215361328_215366837_FF 11.60785382 11.56632535 Hg38_2_215158440_215163198_215361328_215366837_FF 11.60785382 11.56632535 Hg38_2_215158440_215163198_215361328_215366837_FR 11.87301735 11.76244117 Hg38_2_215158440_215163198_215361328_215366837_FR 11.87301735 11.76244117 Hg38_2_215158440_215163198_215361328_215366837_FR 11.87301735 11.76244117 Hg38_2_25430344_25439297_25534468_25543374_RR 12.42330869 12.2874137 Hg38_2_25430344_25439297_25534468_25543374_RR 12.42330869 12.2874137 Hg38_2_25430344_25439297_25534468_25543374_RR 12.42330869 12.2874137 Hg38_2_25534468_25543374_25754113_25757244_RF 12.32564298 12.25020343 Hg38_2_25534468_25543374_25754113_25757244_RF 12.32564298 12.25020343 Hg38_2_25534468_25543374_25754113_25757244_RF 12.32564298 12.25020343 Hg38_2_33600570_33607718_33776012_33779671_FR 12.04450282 11.86912561 Hg38_2_33600570_33607718_33776012_33779671_FR 12.04450282 11.86912561 Hg38_2_33600570_33607718_33776012_33779671_FR 12.04450282 11.86912561 Hg38_2_37866073_37875228_37970917_37977306_RF 11.74479804 11.66943896 Hg38_2_37866073_37875228_37970917_37977306_RF 11.74479804 11.66943896 Hg38_2_37866073_37875228_37970917_37977306_RF 11.74479804 11.66943896 Hg38_2_37970917_37977306_38064697_38067302_FF 11.66639858 11.62207793 Hg38_2_37970917_37977306_38064697_38067302_FF 11.66639858 11.62207793 Hg38_2_37970917_37977306_38064697_38067302_FF 11.66639858 11.62207793 Hg38_2_37970917_37977306_38064697_38067302_FR 11.28378624 11.19408961 Hg38_2_37970917_37977306_38064697_38067302_FR 11.28378624 11.19408961 Hg38_2_37970917_37977306_38064697_38067302_FR 11.28378624 11.19408961 Hg38_2_37970917_37977306_38080719_38088192_FR 12.315539 12.2034011 Hg38_2_37970917_37977306_38080719_38088192_FR 12.315539 12.2034011 Hg38_2_37970917_37977306_38080719_38088192_FR 12.315539 12.2034011 Hg38_2_37970917_37977306_38110623_38114294_FF 11.73191561 11.60833062 Hg38_2_37970917_37977306_38110623_38114294_FF 11.73191561 11.60833062 Hg38_2_37970917_37977306_38110623_38114294_FF 11.73191561 11.60833062 Hg38_2_37970917_37977306_38110623_38114294_FR 12.30067813 12.2355199 Hg38_2_37970917_37977306_38110623_38114294_FR 12.30067813 12.2355199 Hg38_2_37970917_37977306_38110623_38114294_FR 12.30067813 12.2355199 Hg38_2_37970917_37977306_38148629_38155476_FR 11.6440723 11.60991048 Hg38_2_37970917_37977306_38148629_38155476_FR 11.6440723 11.60991048 Hg38_2_37970917_37977306_38148629_38155476_FR 11.6440723 11.60991048 Hg38_2_37970917_37977306_38191088_38194348_FF 11.71546896 11.60860209 Hg38_2_37970917_37977306_38191088_38194348_FF 11.71546896 11.60860209 Hg38_2_37970917_37977306_38191088_38194348_FF 11.71546896 11.60860209 Hg38_2_37970917_37977306_38213262_38223994_FF 12.35725068 12.21503532 Hg38_2_37970917_37977306_38213262_38223994_FF 12.35725068 12.21503532 Hg38_2_37970917_37977306_38213262_38223994_FF 12.35725068 12.21503532 Hg38_2_37970917_37977306_38224311_38232092_FF 11.57572872 11.53665848 Hg38_2_37970917_37977306_38224311_38232092_FF 11.57572872 11.53665848 Hg38_2_37970917_37977306_38224311_38232092_FF 11.57572872 11.53665848 Hg38_2_86124517_86133190_86342524_86346407_FF 12.21049877 12.12684437 Hg38_2_86124517_86133190_86342524_86346407_FF 12.21049877 12.12684437 Hg38_2_86124517_86133190_86342524_86346407_FF 12.21049877 12.12684437 Hg38_2_86124517_86133190_86342524_86346407_FF 12.21049877 12.12684437 Hg38_22_18066616_18069848_18175134_18178766_RF 12.00721863 11.73738045 Hg38_22_18066616_18069848_18175134_18178766_RF 12.00721863 11.73738045 Hg38_22_18066616_18069848_18175134_18178766_RF 12.00721863 11.73738045 Hg38_22_18130971_18134555_18175134_18178766_RF 11.9614912 11.71537863 Hg38_22_18130971_18134555_18175134_18178766_RF 11.9614912 11.71537863 Hg38_22_18130971_18134555_18175134_18178766_RF 11.9614912 11.71537863 Hg38_22_18156094_18157910_18212140_18219987_RR 11.58906163 11.38063571 Hg38_22_18156094_18157910_18212140_18219987_RR 11.58906163 11.38063571 Hg38_22_18156094_18157910_18212140_18219987_RR 11.58906163 11.38063571 Hg38_22_18172062_18175134_18358927_18362558_RF 11.85870532 11.55193957 Hg38_22_18172062_18175134_18358927_18362558_RF 11.85870532 11.55193957 Hg38_22_18172062_18175134_18358927_18362558_RF 11.85870532 11.55193957 Hg38_22_18186838_18199734_18346687_18348300_RR 12.08015134 11.76804874 Hg38_22_18186838_18199734_18346687_18348300_RR 12.08015134 11.76804874 Hg38_22_18186838_18199734_18346687_18348300_RR 12.08015134 11.76804874 Hg38_22_18212140_18219987_18343287_18346687_RF 11.64878696 11.31716665 Hg38_22_18212140_18219987_18343287_18346687_RF 11.64878696 11.31716665 Hg38_22_18212140_18219987_18343287_18346687_RF 11.64878696 11.31716665 Hg38_22_18346687_18348300_18371145_18384031_RF 12.06380717 11.71191437 Hg38_22_18346687_18348300_18371145_18384031_RF 12.06380717 11.71191437 Hg38_22_18346687_18348300_18371145_18384031_RF 12.06380717 11.71191437 Hg38_22_18346687_18348300_18515712_18519924_RF 11.84714923 11.57487454 Hg38_22_18346687_18348300_18515712_18519924_RF 11.84714923 11.57487454 Hg38_22_18346687_18348300_18515712_18519924_RF 11.84714923 11.57487454 Hg38_22_18346687_18348300_18556666_18566500_RR 11.97341277 11.66032154 Hg38_22_18346687_18348300_18556666_18566500_RR 11.97341277 11.66032154 Hg38_22_18346687_18348300_18556666_18566500_RR 11.97341277 11.66032154 Hg38_22_18371145_18384031_18514099_18515712_FF 11.47600839 11.16471836 Hg38_22_18371145_18384031_18514099_18515712_FF 11.47600839 11.16471836 Hg38_22_18371145_18384031_18514099_18515712_FF 11.47600839 11.16471836 Hg38_22_18371145_18384031_18514099_18515712_RF 12.00276352 11.84894507 Hg38_22_18371145_18384031_18514099_18515712_RF 12.00276352 11.84894507 Hg38_22_18371145_18384031_18514099_18515712_RF 12.00276352 11.84894507 Hg38_22_18515712_18519924_18723447_18726523_RR 12.24299821 12.08913207 Hg38_22_18515712_18519924_18723447_18726523_RR 12.24299821 12.08913207 Hg38_22_18515712_18519924_18723447_18726523_RR 12.24299821 12.08913207 Hg38_22_18603563_18606805_18771420_18773033_FF 11.71149877 11.5201814 Hg38_22_18603563_18606805_18771420_18773033_FF 11.71149877 11.5201814 Hg38_22_18603563_18606805_18771420_18773033_FF 11.71149877 11.5201814 Hg38_22_18793416_18800484_19045461_19047764_FF 11.51708143 11.36539672 Hg38_22_18793416_18800484_19045461_19047764_FF 11.51708143 11.36539672 Hg38_22_18793416_18800484_19045461_19047764_FF 11.51708143 11.36539672 Hg38_22_18793416_18800484_19045461_19047764_FF 11.51708143 11.36539672 Hg38_22_18850719_18854897_18914083_18921389_RR 11.42971349 11.07146518 Hg38_22_18850719_18854897_18914083_18921389_RR 11.42971349 11.07146518 Hg38_22_18850719_18854897_18914083_18921389_RR 11.42971349 11.07146518 Hg38_22_20853272_20859143_21119671_21123850_RF 11.4088302 11.09053273 Hg38_22_20853272_20859143_21119671_21123850_RF 11.4088302 11.09053273 Hg38_22_20853272_20859143_21119671_21123850_RF 11.4088302 11.09053273 Hg38_22_20853272_20859143_21119671_21123850_RF 11.4088302 11.09053273 Hg38_22_20853272_20859143_21119671_21123850_RF 11.4088302 11.09053273 Hg38_22_20853272_20859143_21119671_21123850_RF 11.4088302 11.09053273 Hg38_22_20853272_20859143_21119671_21123850_RF 11.4088302 11.09053273 Hg38_22_20853272_20859143_21119671_21123850_RF 11.4088302 11.09053273 Hg38_22_20853272_20859143_21119671_21123850_RF 11.4088302 11.09053273 Hg38_22_20937891_20943308_21119671_21123850_RF 11.69702419 11.34392559 Hg38_22_20937891_20943308_21119671_21123850_RF 11.69702419 11.34392559 Hg38_22_20937891_20943308_21119671_21123850_RF 11.69702419 11.34392559 Hg38_22_20937891_20943308_21119671_21123850_RF 11.69702419 11.34392559 Hg38_22_20937891_20943308_21119671_21123850_RF 11.69702419 11.34392559 Hg38_22_20937891_20943308_21119671_21123850_RF 11.69702419 11.34392559 Hg38_22_20937891_20943308_21119671_21123850_RF 11.69702419 11.34392559 Hg38_22_21119671_21123850_21227748_21234806_FF 12.15146863 11.82830718 Hg38_22_21119671_21123850_21227748_21234806_FF 12.15146863 11.82830718 Hg38_22_21119671_21123850_21227748_21234806_FF 12.15146863 11.82830718 Hg38_22_21132101_21137434_21207349_21210763_FR 11.90577525 11.71768209 Hg38_22_21132101_21137434_21207349_21210763_FR 11.90577525 11.71768209 Hg38_22_21132101_21137434_21207349_21210763_FR 11.90577525 11.71768209 Hg38_22_21132101_21137434_21227748_21234806_FF 11.88939259 11.72625112 Hg38_22_21132101_21137434_21227748_21234806_FF 11.88939259 11.72625112 Hg38_22_21132101_21137434_21227748_21234806_FF 11.88939259 11.72625112 Hg38_22_21169952_21182838_21297851_21301725_RF 11.84956337 11.54745896 Hg38_22_21169952_21182838_21297851_21301725_RF 11.84956337 11.54745896 Hg38_22_21169952_21182838_21297851_21301725_RF 11.84956337 11.54745896 Hg38_22_22425661_22435652_22644477_22649197_RF 11.56683931 11.32909216 Hg38_22_22425661_22435652_22644477_22649197_RF 11.56683931 11.32909216 Hg38_22_22425661_22435652_22644477_22649197_RF 11.56683931 11.32909216 Hg38_22_22425661_22435652_22644477_22649197_RF 11.56683931 11.32909216 Hg38_22_22443554_22451851_22644477_22649197_RF 12.18627865 11.96761481 Hg38_22_22443554_22451851_22644477_22649197_RF 12.18627865 11.96761481 Hg38_22_22443554_22451851_22644477_22649197_RF 12.18627865 11.96761481 Hg38_22_22443554_22451851_22644477_22649197_RF 12.18627865 11.96761481 Hg38_22_22644477_22649197_22663948_22672129_FR 11.84482092 11.63235559 Hg38_22_22644477_22649197_22663948_22672129_FR 11.84482092 11.63235559 Hg38_22_22644477_22649197_22663948_22672129_FR 11.84482092 11.63235559 Hg38_22_22644477_22649197_22691505_22697411_FF 12.21722085 11.95068008 Hg38_22_22644477_22649197_22691505_22697411_FF 12.21722085 11.95068008 Hg38_22_22644477_22649197_22691505_22697411_FF 12.21722085 11.95068008 Hg38_22_22644477_22649197_22735930_22739304_FR 11.81324627 11.54604076 Hg38_22_22644477_22649197_22735930_22739304_FR 11.81324627 11.54604076 Hg38_22_22644477_22649197_22735930_22739304_FR 11.81324627 11.54604076 Hg38_22_22644477_22649197_22746169_22755064_FR 11.99896524 11.70238117 Hg38_22_22644477_22649197_22746169_22755064_FR 11.99896524 11.70238117 Hg38_22_22644477_22649197_22746169_22755064_FR 11.99896524 11.70238117 Hg38_22_24626213_24630295_24649759_24655342_FR 11.37938857 11.05087549 Hg38_22_24626213_24630295_24649759_24655342_FR 11.37938857 11.05087549 Hg38_22_24626213_24630295_24649759_24655342_FR 11.37938857 11.05087549 Hg38_22_24626213_24630295_24772075_24777926_FR 11.61928889 11.33061872 Hg38_22_24626213_24630295_24772075_24777926_FR 11.61928889 11.33061872 Hg38_22_24626213_24630295_24772075_24777926_FR 11.61928889 11.33061872 Hg38_22_24649759_24655342_24891397_24897177_RR 11.64302348 11.4798165 Hg38_22_24649759_24655342_24891397_24897177_RR 11.64302348 11.4798165 Hg38_22_24649759_24655342_24891397_24897177_RR 11.64302348 11.4798165 Hg38_3_152218027_152223492_152340254_152343605_RF 11.8911621 11.7666166 Hg38_3_152218027_152223492_152340254_152343605_RF 11.8911621 11.7666166 Hg38_3_152218027_152223492_152340254_152343605_RF 11.8911621 11.7666166 Hg38_3_186196358_186204775_186430374_186435301_RF 12.16610966 12.11066389 Hg38_3_186196358_186204775_186430374_186435301_RF 12.16610966 12.11066389 Hg38_3_186196358_186204775_186430374_186435301_RF 12.16610966 12.11066389 Hg38_3_186430374_186435301_186455150_186462012_FR 11.78432618 11.67704889 Hg38_3_186430374_186435301_186455150_186462012_FR 11.78432618 11.67704889 Hg38_3_186430374_186435301_186455150_186462012_FR 11.78432618 11.67704889 Hg38_3_186430374_186435301_186583724_186589799_FR 11.75481654 11.65168348 Hg38_3_186430374_186435301_186583724_186589799_FR 11.75481654 11.65168348 Hg38_3_186430374_186435301_186583724_186589799_FR 11.75481654 11.65168348 Hg38_3_196244641_196248018_196327068_196332743_RR 12.29954772 12.21525405 Hg38_3_196244641_196248018_196327068_196332743_RR 12.29954772 12.21525405 Hg38_3_196244641_196248018_196327068_196332743_RR 12.29954772 12.21525405 Hg38_3_196244641_196248018_196327068_196332743_RR 12.29954772 12.21525405 Hg38_3_196244641_196248018_196327068_196332743_RR 12.29954772 12.21525405 Hg38_3_4984183_4985754_5242837_5249780_FR 12.33232804 12.22649774 Hg38_3_4984183_4985754_5242837_5249780_FR 12.33232804 12.22649774 Hg38_3_4984183_4985754_5242837_5249780_FR 12.33232804 12.22649774 Hg38_3_5136007_5138835_5242837_5249780_FR 12.22174994 12.13280126 Hg38_3_5136007_5138835_5242837_5249780_FR 12.22174994 12.13280126 Hg38_3_5136007_5138835_5242837_5249780_FR 12.22174994 12.13280126 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51805688_51812156_51990777_51993945_FR 11.20517045 11.0629181 Hg38_3_51866355_51870960_51990777_51993945_RR 11.58494007 11.46753919 Hg38_3_51866355_51870960_51990777_51993945_RR 11.58494007 11.46753919 Hg38_3_51866355_51870960_51990777_51993945_RR 11.58494007 11.46753919 Hg38_3_51866355_51870960_51990777_51993945_RR 11.58494007 11.46753919 Hg38_3_51866355_51870960_51990777_51993945_RR 11.58494007 11.46753919 Hg38_3_51866355_51870960_51990777_51993945_RR 11.58494007 11.46753919 Hg38_3_51866355_51870960_51990777_51993945_RR 11.58494007 11.46753919 Hg38_3_51866355_51870960_51990777_51993945_RR 11.58494007 11.46753919 Hg38_3_51866355_51870960_51990777_51993945_RR 11.58494007 11.46753919 Hg38_3_51866355_51870960_51990777_51993945_RR 11.58494007 11.46753919 Hg38_3_51866355_51870960_51990777_51993945_RR 11.58494007 11.46753919 Hg38_3_51866355_51870960_51990777_51993945_RR 11.58494007 11.46753919 Hg38_3_51990777_51993945_52112802_52116979_RF 11.62041679 11.5319832 Hg38_3_51990777_51993945_52112802_52116979_RF 11.62041679 11.5319832 Hg38_3_51990777_51993945_52112802_52116979_RF 11.62041679 11.5319832 Hg38_4_11918401_11924084_12044993_12048614_RF 12.13332771 11.96093935 Hg38_4_11918401_11924084_12044993_12048614_RF 12.13332771 11.96093935 Hg38_4_11918401_11924084_12044993_12048614_RF 12.13332771 11.96093935 Hg38_4_11918401_11924084_12065211_12069780_RF 11.64193217 11.52110943 Hg38_4_11918401_11924084_12065211_12069780_RF 11.64193217 11.52110943 Hg38_4_11918401_11924084_12065211_12069780_RF 11.64193217 11.52110943 Hg38_4_189203993_189207508_189228516_189236557_FF 11.338374 11.20762571 Hg38_4_189203993_189207508_189228516_189236557_FF 11.338374 11.20762571 Hg38_4_189203993_189207508_189228516_189236557_FF 11.338374 11.20762571 Hg38_4_4107083_4112716_4301619_4308774_RR 11.28844357 11.18069277 Hg38_4_4107083_4112716_4301619_4308774_RR 11.28844357 11.18069277 Hg38_4_4107083_4112716_4301619_4308774_RR 11.28844357 11.18069277 Hg38_4_4107083_4112716_4301619_4308774_RR 11.28844357 11.18069277 Hg38_5_120042817_120060309_120141576_120148256_FF 11.67840547 11.59278092 Hg38_5_120042817_120060309_120141576_120148256_FF 11.67840547 11.59278092 Hg38_5_120042817_120060309_120141576_120148256_FF 11.67840547 11.59278092 Hg38_5_156505143_156509818_156646809_156658691_RF 11.5057444 11.40337964 Hg38_5_156505143_156509818_156646809_156658691_RF 11.5057444 11.40337964 Hg38_5_156505143_156509818_156646809_156658691_RF 11.5057444 11.40337964 Hg38_5_180460489_180471506_180526401_180531032_RF 11.80420118 11.7179852 Hg38_5_180460489_180471506_180526401_180531032_RF 11.80420118 11.7179852 Hg38_5_180460489_180471506_180526401_180531032_RF 11.80420118 11.7179852 Hg38_5_180526401_180531032_180568808_180570155_FR 11.64378894 11.58525546 Hg38_5_180526401_180531032_180568808_180570155_FR 11.64378894 11.58525546 Hg38_5_180526401_180531032_180568808_180570155_FR 11.64378894 11.58525546 Hg38_5_180526401_180531032_180638324_180642099_FR 12.10814608 12.01788018 Hg38_5_180526401_180531032_180638324_180642099_FR 12.10814608 12.01788018 Hg38_5_180526401_180531032_180638324_180642099_FR 12.10814608 12.01788018 Hg38_5_180526401_180531032_180690626_180702426_FF 11.84803314 11.74565304 Hg38_5_180526401_180531032_180690626_180702426_FF 11.84803314 11.74565304 Hg38_5_180526401_180531032_180690626_180702426_FF 11.84803314 11.74565304 Hg38_5_23773857_23781083_23937675_23951502_FF 11.61458145 11.52610347 Hg38_5_23773857_23781083_23937675_23951502_FF 11.61458145 11.52610347 Hg38_5_23773857_23781083_23937675_23951502_FF 11.61458145 11.52610347 Hg38_5_54242076_54248647_54409935_54420505_RF 11.85030094 11.77749837 Hg38_5_54242076_54248647_54409935_54420505_RF 11.85030094 11.77749837 Hg38_5_54242076_54248647_54409935_54420505_RF 11.85030094 11.77749837 Hg38_5_54283041_54284324_54409935_54420505_RF 11.70491609 11.6523342 Hg38_5_54283041_54284324_54409935_54420505_RF 11.70491609 11.6523342 Hg38_5_54283041_54284324_54409935_54420505_RF 11.70491609 11.6523342 Hg38_5_54312719_54320970_54409935_54420505_RF 11.89579545 11.84003617 Hg38_5_54312719_54320970_54409935_54420505_RF 11.89579545 11.84003617 Hg38_5_54312719_54320970_54409935_54420505_RF 11.89579545 11.84003617 Hg38_5_54394172_54398681_54409935_54420505_RF 11.66450551 11.53914749 Hg38_5_54394172_54398681_54409935_54420505_RF 11.66450551 11.53914749 Hg38_5_54394172_54398681_54409935_54420505_RF 11.66450551 11.53914749 Hg38_5_54409935_54420505_54445476_54448805_FR 11.75970924 11.68704774 Hg38_5_54409935_54420505_54445476_54448805_FR 11.75970924 11.68704774 Hg38_5_54409935_54420505_54445476_54448805_FR 11.75970924 11.68704774 Hg38_5_54409935_54420505_54459016_54463470_FR 11.56975336 11.51647138 Hg38_5_54409935_54420505_54459016_54463470_FR 11.56975336 11.51647138 Hg38_5_54409935_54420505_54459016_54463470_FR 11.56975336 11.51647138 Hg38_5_54409935_54420505_54463470_54464610_FF 11.79660071 11.71147174 Hg38_5_54409935_54420505_54463470_54464610_FF 11.79660071 11.71147174 Hg38_5_54409935_54420505_54463470_54464610_FF 11.79660071 11.71147174 Hg38_5_54409935_54420505_54513308_54517873_FF 12.2869995 12.18258034 Hg38_5_54409935_54420505_54513308_54517873_FF 12.2869995 12.18258034 Hg38_5_54409935_54420505_54513308_54517873_FF 12.2869995 12.18258034 Hg38_5_54409935_54420505_54513308_54517873_FR 12.14422972 12.06047584 Hg38_5_54409935_54420505_54513308_54517873_FR 12.14422972 12.06047584 Hg38_5_54409935_54420505_54513308_54517873_FR 12.14422972 12.06047584 Hg38_5_54409935_54420505_54525973_54530429_FF 11.84713802 11.72281182 Hg38_5_54409935_54420505_54525973_54530429_FF 11.84713802 11.72281182 Hg38_5_54409935_54420505_54525973_54530429_FF 11.84713802 11.72281182 Hg38_5_54409935_54420505_54525973_54530429_FR 11.63007488 11.53499494 Hg38_5_54409935_54420505_54525973_54530429_FR 11.63007488 11.53499494 Hg38_5_54409935_54420505_54525973_54530429_FR 11.63007488 11.53499494 Hg38_5_54409935_54420505_54541247_54543319_FF 11.64564722 11.55945222 Hg38_5_54409935_54420505_54541247_54543319_FF 11.64564722 11.55945222 Hg38_5_54409935_54420505_54541247_54543319_FF 11.64564722 11.55945222 Hg38_5_54409935_54420505_54544310_54550804_FR 11.70969471 11.59059888 Hg38_5_54409935_54420505_54544310_54550804_FR 11.70969471 11.59059888 Hg38_5_54409935_54420505_54544310_54550804_FR 11.70969471 11.59059888 Hg38_5_54409935_54420505_54561368_54567522_FR 12.3631177 12.23792655 Hg38_5_54409935_54420505_54561368_54567522_FR 12.3631177 12.23792655 Hg38_5_54409935_54420505_54561368_54567522_FR 12.3631177 12.23792655 Hg38_5_54409935_54420505_54591681_54596908_FF 11.84659859 11.77470791 Hg38_5_54409935_54420505_54591681_54596908_FF 11.84659859 11.77470791 Hg38_5_54409935_54420505_54591681_54596908_FF 11.84659859 11.77470791 Hg38_5_54409935_54420505_54591681_54596908_FR 11.68511525 11.56446765 Hg38_5_54409935_54420505_54591681_54596908_FR 11.68511525 11.56446765 Hg38_5_54409935_54420505_54591681_54596908_FR 11.68511525 11.56446765 Hg38_5_60416104_60420631_60480354_60488512_RR 11.41794096 11.2048357 Hg38_5_60416104_60420631_60480354_60488512_RR 11.41794096 11.2048357 Hg38_5_60416104_60420631_60480354_60488512_RR 11.41794096 11.2048357 Hg38_6_13822111_13826619_13996758_14002590_FF 11.51940198 11.37909299 Hg38_6_13822111_13826619_13996758_14002590_FF 11.51940198 11.37909299 Hg38_6_13822111_13826619_13996758_14002590_FF 11.51940198 11.37909299 Hg38_6_13949646_13967157_14016925_14018522_RF 11.97556963 11.84347145 Hg38_6_13949646_13967157_14016925_14018522_RF 11.97556963 11.84347145 Hg38_6_13949646_13967157_14016925_14018522_RF 11.97556963 11.84347145 Hg38_6_27373373_27380841_27425003_27434505_RR 12.0331217 11.91892866 Hg38_6_27373373_27380841_27425003_27434505_RR 12.0331217 11.91892866 Hg38_6_27373373_27380841_27425003_27434505_RR 12.0331217 11.91892866 Hg38_6_27425003_27434505_27448356_27449458_RF 11.45054251 11.34790997 Hg38_6_27425003_27434505_27448356_27449458_RF 11.45054251 11.34790997 Hg38_6_27425003_27434505_27448356_27449458_RF 11.45054251 11.34790997 Hg38_6_28502666_28507330_28518468_28522511_RR 11.54037028 11.49357241 Hg38_6_28502666_28507330_28518468_28522511_RR 11.54037028 11.49357241 Hg38_6_28502666_28507330_28518468_28522511_RR 11.54037028 11.49357241 Hg38_6_28502666_28507330_28546577_28560475_RR 11.6841531 11.57519187 Hg38_6_28502666_28507330_28546577_28560475_RR 11.6841531 11.57519187 Hg38_6_28502666_28507330_28546577_28560475_RR 11.6841531 11.57519187 Hg38_6_29739096_29744237_29895636_29902173_RR 11.75989504 11.67101458 Hg38_6_29739096_29744237_29895636_29902173_RR 11.75989504 11.67101458 Hg38_6_29739096_29744237_29895636_29902173_RR 11.75989504 11.67101458 Hg38_6_40816112_40822837_41027904_41032556_RR 11.21599355 11.15906167 Hg38_6_40816112_40822837_41027904_41032556_RR 11.21599355 11.15906167 Hg38_6_40816112_40822837_41027904_41032556_RR 11.21599355 11.15906167 Hg38_7_104704855_104709697_104761273_104766155_FF 12.30833446 12.2020333 Hg38_7_104704855_104709697_104761273_104766155_FF 12.30833446 12.2020333 Hg38_7_104704855_104709697_104761273_104766155_FF 12.30833446 12.2020333 Hg38_7_104704855_104709697_104761273_104766155_FR 11.54473289 11.48187082 Hg38_7_104704855_104709697_104761273_104766155_FR 11.54473289 11.48187082 Hg38_7_104704855_104709697_104761273_104766155_FR 11.54473289 11.48187082 Hg38_8_12604552_12608674_12729234_12733612_FR 11.45396308 11.22396053 Hg38_8_12604552_12608674_12729234_12733612_FR 11.45396308 11.22396053 Hg38_8_12604552_12608674_12729234_12733612_FR 11.45396308 11.22396053 Hg38_8_19283426_19290871_19464395_19468709_RF 11.68341919 11.64970164 Hg38_8_19283426_19290871_19464395_19468709_RF 11.68341919 11.64970164 Hg38_8_19283426_19290871_19464395_19468709_RF 11.68341919 11.64970164 Hg38_8_31376503_31381872_31490554_31498615_FR 11.62013215 11.50874365 Hg38_8_31376503_31381872_31490554_31498615_FR 11.62013215 11.50874365 Hg38_8_31376503_31381872_31490554_31498615_FR 11.62013215 11.50874365 Hg38_8_7225538_7229239_7353769_7356597_FF 11.8583926 11.60830936 Hg38_8_7225538_7229239_7353769_7356597_FF 11.8583926 11.60830936 Hg38_8_7225538_7229239_7353769_7356597_FF 11.8583926 11.60830936 Hg38_8_7225538_7229239_7353769_7356597_FR 11.48100254 11.27829332 Hg38_8_7225538_7229239_7353769_7356597_FR 11.48100254 11.27829332 Hg38_8_7225538_7229239_7353769_7356597_FR 11.48100254 11.27829332 Hg38_8_7225538_7229239_7473076_7476031_FF 11.47414777 11.23628326 Hg38_8_7225538_7229239_7473076_7476031_FF 11.47414777 11.23628326 Hg38_8_7225538_7229239_7473076_7476031_FF 11.47414777 11.23628326 Hg38_8_7225538_7229239_7473076_7476031_FF 11.47414777 11.23628326 Hg38_8_7225538_7229239_7473076_7476031_FF 11.47414777 11.23628326 Hg38_8_7225538_7229239_7473076_7476031_FF 11.47414777 11.23628326 Hg38_8_7225538_7229239_7473076_7476031_FF 11.47414777 11.23628326 Hg38_8_7683707_7687809_7776165_7784320_FR 11.52648571 11.29535197 Hg38_8_7683707_7687809_7776165_7784320_FR 11.52648571 11.29535197 Hg38_8_7683707_7687809_7776165_7784320_FR 11.52648571 11.29535197 Hg38_8_94341169_94355205_94369810_94372743_RR 12.23651856 12.15183543 Hg38_8_94341169_94355205_94369810_94372743_RR 12.23651856 12.15183543 Hg38_8_94341169_94355205_94369810_94372743_RR 12.23651856 12.15183543 Hg38_8_94341169_94355205_94383779_94385672_RR 11.74346001 11.63418112 Hg38_8_94341169_94355205_94383779_94385672_RR 11.74346001 11.63418112 Hg38_8_94341169_94355205_94383779_94385672_RR 11.74346001 11.63418112 Hg38_8_94341169_94355205_94409924_94418693_RR 12.22732768 12.13135392 Hg38_8_94341169_94355205_94409924_94418693_RR 12.22732768 12.13135392 Hg38_8_94341169_94355205_94409924_94418693_RR 12.22732768 12.13135392 Hg38_8_94341169_94355205_94431491_94436681_RR 11.44987769 11.38005784 Hg38_8_94341169_94355205_94431491_94436681_RR 11.44987769 11.38005784 Hg38_8_94341169_94355205_94431491_94436681_RR 11.44987769 11.38005784 Hg38_8_94341169_94355205_94447981_94450677_RR 11.6608282 11.61486148 Hg38_8_94341169_94355205_94447981_94450677_RR 11.6608282 11.61486148 Hg38_8_94341169_94355205_94447981_94450677_RR 11.6608282 11.61486148 Hg38_8_94341169_94355205_94456612_94459954_RR 11.82905019 11.75099946 Hg38_8_94341169_94355205_94456612_94459954_RR 11.82905019 11.75099946 Hg38_8_94341169_94355205_94456612_94459954_RR 11.82905019 11.75099946 Hg38_9_34636429_34638427_34736391_34740010_FF 11.55530226 11.42809328 Hg38_9_34636429_34638427_34736391_34740010_FF 11.55530226 11.42809328 Hg38_9_34636429_34638427_34736391_34740010_FF 11.55530226 11.42809328 Hg38_9_34636429_34638427_34736391_34740010_FF 11.55530226 11.42809328 Hg38_9_34636429_34638427_34736391_34740010_FF 11.55530226 11.42809328 Hg38_9_34636429_34638427_34736391_34740010_FF 11.55530226 11.42809328 Hg38_9_34636429_34638427_34736391_34740010_FF 11.55530226 11.42809328 Hg38_9_34636429_34638427_34736391_34740010_FF 11.55530226 11.42809328 Hg38_9_34636429_34638427_34736391_34740010_FF 11.55530226 11.42809328 Hg38_9_37891406_37895286_37939740_37942436_RR 11.75532548 11.66243114 Hg38_9_37891406_37895286_37939740_37942436_RR 11.75532548 11.66243114 Hg38_9_37891406_37895286_37939740_37942436_RR 11.75532548 11.66243114 Hg38_9_37891406_37895286_37961997_37965594_RR 12.24184394 12.13390573 Hg38_9_37891406_37895286_37961997_37965594_RR 12.24184394 12.13390573 Hg38_9_37891406_37895286_37961997_37965594_RR 12.24184394 12.13390573 Hg38_9_37891406_37895286_38017052_38021135_RR 11.62990618 11.56892335 Hg38_9_37891406_37895286_38017052_38021135_RR 11.62990618 11.56892335 Hg38_9_37891406_37895286_38017052_38021135_RR 11.62990618 11.56892335 Hg38_9_37891406_37895286_38026003_38029710_RR 12.00358122 11.9475607 Hg38_9_37891406_37895286_38026003_38029710_RR 12.00358122 11.9475607 Hg38_9_37891406_37895286_38026003_38029710_RR 12.00358122 11.9475607 Hg38_9_37891406_37895286_38062338_38065946_RR 11.87479149 11.82523213 Hg38_9_37891406_37895286_38062338_38065946_RR 11.87479149 11.82523213 Hg38_9_37891406_37895286_38062338_38065946_RR 11.87479149 11.82523213 Hg38_9_684461_692812_858671_861528_RF 11.8644408 11.78191265 Hg38_9_684461_692812_858671_861528_RF 11.8644408 11.78191265 Hg38_9_684461_692812_858671_861528_RF 11.8644408 11.78191265 Hg38_9_858671_861528_981023_982427_FR 11.49066987 11.41017441 Hg38_9_858671_861528_981023_982427_FR 11.49066987 11.41017441 Hg38_9_858671_861528_981023_982427_FR 11.49066987 11.41017441 Hg38_9_95576800_95586322_95681020_95683648_RR 11.91363129 11.77277484 Hg38_9_95576800_95586322_95681020_95683648_RR 11.91363129 11.77277484 Hg38_9_95576800_95586322_95681020_95683648_RR 11.91363129 11.77277484 Hg38_X_103105397_103106922_103214158_103216340_FF 12.37276093 12.15393759 Hg38_X_103105397_103106922_103214158_103216340_FF 12.37276093 12.15393759 Hg38_X_103105397_103106922_103214158_103216340_FF 12.37276093 12.15393759 Hg38_X_119167630_119177060_119334321_119339599_FR 11.91544933 11.77103417 Hg38_X_119167630_119177060_119334321_119339599_FR 11.91544933 11.77103417 Hg38_X_119167630_119177060_119334321_119339599_FR 11.91544933 11.77103417 Hg38_X_135326340_135335288_135346410_135357250_RF 11.70622707 11.57337886 Hg38_X_135326340_135335288_135346410_135357250_RF 11.70622707 11.57337886 Hg38_X_135326340_135335288_135346410_135357250_RF 11.70622707 11.57337886 Hg38_X_65967460_65975170_66017310_66021076_FR 11.79089012 11.65391568 Hg38_X_65967460_65975170_66017310_66021076_FR 11.79089012 11.65391568 Hg38_X_65967460_65975170_66017310_66021076_FR 11.79089012 11.65391568 784 Hg38_X_65967460_65975170_66049278_66054565_FF 11.80833637 11.70549733 785 Hg38_X_65967460_65975170_66049278_66054565_FF 11.80833637 11.70549733 786 Hg38_X_65967460_65975170_66049278_66054565_FF 11.80833637 11.70549733 787 Hg38_X_80215387_80223614_80235737_80240294_RR 12.3214628 12.17841562 788 Hg38_X_80215387_80223614_80235737_80240294_RR 12.3214628 12.17841562 789 Hg38_X_80215387_80223614_80235737_80240294_RR 12.3214628 12.17841562 790 Hg38_X_80215387_80223614_80292274_80296541_RR 11.62379303 11.5051363 791 Hg38_X_80215387_80223614_80292274_80296541_RR 11.62379303 11.5051363 792 Hg38_X_80215387_80223614_80292274_80296541_RR 11.62379303 11.5051363 793 Hg38_X_80215387_80223614_80309061_80316254_RR 12.37081796 12.24090828 794 Hg38_X_80215387_80223614_80309061_80316254_RR 12.37081796 12.24090828 795 Hg38_X_80215387_80223614_80309061_80316254_RR 12.37081796 12.24090828 796 Hg38_X_80215387_80223614_80354869_80360257_RR 11.7991115 11.71063021 797 Hg38_X_80215387_80223614_80354869_80360257_RR 11.7991115 11.71063021 798 Hg38_X_80215387_80223614_80354869_80360257_RR 11.7991115 11.71063021 Table 6(b) T3 T4 P.value adj.P.Val FC gene distance 11.5795817 11.28240861 0.0005087 0.030988496 -1.125522839 AMY1A 490589 07 11.5795817 11.28240861 0.0005087 0.030988496 -1.125522839 AMY1C 396453 07 11.5795817 11.28240861 0.0005087 0.030988496 -1.125522839 AMY1B 458463 07 11.0303101 11.00051344 0.0007857 0.033598104 -1.10689573 CD2 0 6 48 11.0303101 11.00051344 0.0007857 0.033598104 -1.10689573 IGSF3 0 6 48 11.0303101 11.00051344 0.0007857 0.033598104 -1.10689573 C1orf137 0 6 48 11.5380078 11.23490668 0.0009290 0.034970971 -1.117203407 TAF1A 498037 7 62 11.5380078 11.23490668 0.0009290 0.034970971 -1.117203407 HHIPL2 462393 7 62 11.5380078 11.23490668 0.0009290 0.034970971 -1.117203407 DUSP10 161527 7 62 0 11.5684183 11.28850403 0.0007437 0.033519117 -1.112588225 HHIPL2 302524 7 44 1 11.5684183 11.28850403 0.0007437 0.033519117 -1.112588225 TAF1A 338168 7 44 2 11.5684183 11.28850403 0.0007437 0.033519117 -1.112588225 DUSP10 308177 7 44 3 12.0357053 11.85489133 0.0001403 0.027503923 -1.128558384 NVL 50603 91 4 12.0357053 11.85489133 0.0001403 0.027503923 -1.128558384 FBXO28 0 91 12.0357053 11.85489133 0.0001403 0.027503923 -1.128558384 DEGS1 0 91 11.6895838 11.42003553 0.0001674 0.027503923 -1.13087925 SH3BP5L 3897 7 2 11.6895838 11.42003553 0.0001674 0.027503923 -1.13087925 ZNF692 0 7 2 11.6895838 11.42003553 0.0001674 0.027503923 -1.13087925 ZNF672 0 7 2 11.3443001 11.12081994 0.0002268 0.027503923 -1.116420451 ZNF692 0 6 64 11.3443001 11.12081994 0.0002268 0.027503923 -1.116420451 ZNF672 0 6 64 11.3443001 11.12081994 0.0002268 0.027503923 -1.116420451 PGBD2 284 6 64 12.0794512 11.82987277 0.0001301 0.027503923 -1.134758867 PGBD2 0 3 36 12.0794512 11.82987277 0.0001301 0.027503923 -1.134758867 ZNF672 0 3 36 12.0794512 11.82987277 0.0001301 0.027503923 -1.134758867 ZNF692 0 3 36 11.9357458 11.66054824 0.0005556 0.031459834 -1.115265396 SMAP2 0 54 11.9357458 11.66054824 0.0005556 0.031459834 -1.115265396 ZFP69B 0 54 11.9357458 11.66054824 0.0005556 0.031459834 -1.115265396 EXO5 0 54 11.9357458 11.66054824 0.0005556 0.031459834 -1.115265396 ZFP69 0 54 11.218637 10.89440108 0.0002135 0.027503923 -1.147613797 CYB5RL 0 14 11.218637 10.89440108 0.0002135 0.027503923 -1.147613797 SSBP3 0 14 11.218637 10.89440108 0.0002135 0.027503923 -1.147613797 RP11- 0 14 446E24.4 11.218637 10.89440108 0.0002135 0.027503923 -1.147613797 MRPL37 0 14 11.2129588 10.8485588 0.0004841 0.030334659 -1.148745138 RP11- 22046 3 3 446E24.4 11.2129588 10.8485588 0.0004841 0.030334659 -1.148745138 SSBP3 0 3 3 11.2129588 10.8485588 0.0004841 0.030334659 -1.148745138 MRPL37 0 3 3 11.0919784 10.70947215 0.0003065 0.029009077 -1.165530138 MRPL37 0 3 98 11.0919784 10.70947215 0.0003065 0.029009077 -1.165530138 SSBP3 0 3 98 11.0919784 10.70947215 0.0003065 0.029009077 -1.165530138 RP11- 22046 3 98 446E24.4 10.9624862 10.53553752 0.0006766 0.033115763 -1.166362918 SSBP3 0 6 65 10.9624862 10.53553752 0.0006766 0.033115763 -1.166362918 MRPL37 0 6 65 10.9624862 10.53553752 0.0006766 0.033115763 -1.166362918 RP11- 22046 6 65 446E24.4 11.7592260 11.48643866 0.0005392 0.031253143 -1.115768824 GBP4 10538 5 21 11.7592260 11.48643866 0.0005392 0.031253143 -1.115768824 GBP2 0 5 21 11.7592260 11.48643866 0.0005392 0.031253143 -1.115768824 GBP7 0 5 21 11.9537186 11.459736 0.0008101 0.033873617 -1.190325193 C10orf88 0 5 11 11.9537186 11.459736 0.0008101 0.033873617 -1.190325193 PSTK 0 5 11 11.9537186 11.459736 0.0008101 0.033873617 -1.190325193 ACADSB 0 5 11 11.9537186 11.459736 0.0008101 0.033873617 -1.190325193 IKZF5 0 5 11 11.9537186 11.459736 0.0008101 0.033873617 -1.190325193 FAM24B 0 5 11 11.9537186 11.459736 0.0008101 0.033873617 -1.190325193 FAM24A 0 5 11 12.1345978 11.68978324 0.0009941 0.035439335 -1.169537118 ACADSB 0 7 91 12.1345978 11.68978324 0.0009941 0.035439335 -1.169537118 C10orf88 0 7 91 12.1345978 11.68978324 0.0009941 0.035439335 -1.169537118 IKZF5 0 7 91 12.1345978 11.68978324 0.0009941 0.035439335 -1.169537118 FAM24B 0 7 91 12.1345978 11.68978324 0.0009941 0.035439335 -1.169537118 PSTK 0 7 91 12.1345978 11.68978324 0.0009941 0.035439335 -1.169537118 FAM24A 0 7 91 12.0186930 11.66783893 0.0008386 0.034347424 -1.139316925 PSTK 0 4 22 12.0186930 11.66783893 0.0008386 0.034347424 -1.139316925 ACADSB 0 4 22 12.0186930 11.66783893 0.0008386 0.034347424 -1.139316925 FAM24A 0 4 22 12.0186930 11.66783893 0.0008386 0.034347424 -1.139316925 C10orf88 0 4 22 12.0186930 11.66783893 0.0008386 0.034347424 -1.139316925 IKZF5 0 4 22 11.4698453 11.25600686 0.0003754 0.029177899 -1.119328431 FANK1 0 8 29 11.4698453 11.25600686 0.0003754 0.029177899 -1.119328431 EDRF1 0 8 29 11.4698453 11.25600686 0.0003754 0.029177899 -1.119328431 MMP21 0 8 29 11.4698453 11.25600686 0.0003754 0.029177899 -1.119328431 UROS 0 8 29 11.4698453 11.25600686 0.0003754 0.029177899 -1.119328431 BCCIP 0 8 29 11.4698453 11.25600686 0.0003754 0.029177899 -1.119328431 DHX32 0 8 29 11.4177432 11.20705413 9.91974E- 0.027503923 -1.123950001 EDRF1 0 6 05 11.4177432 11.20705413 9.91974E- 0.027503923 -1.123950001 BCCIP 0 6 05 11.4177432 11.20705413 9.91974E- 0.027503923 -1.123950001 DHX32 0 6 05 11.4177432 11.20705413 9.91974E- 0.027503923 -1.123950001 FANK1 0 6 05 11.4177432 11.20705413 9.91974E- 0.027503923 -1.123950001 UROS 0 6 05 11.4177432 11.20705413 9.91974E- 0.027503923 -1.123950001 MMP21 0 6 05 11.8446217 11.57620135 0.0005310 0.031201337 -1.120529986 DHX32 0 6 95 11.8446217 11.57620135 0.0005310 0.031201337 -1.120529986 BCCIP 3193 6 95 11.8446217 11.57620135 0.0005310 0.031201337 -1.120529986 FANK1 0 6 95 11.3141241 11.08670587 0.0002091 0.027503923 -1.126550265 DHX32 68521 4 61 11.3141241 11.08670587 0.0002091 0.027503923 -1.126550265 ADAM12 0 4 61 11.3141241 11.08670587 0.0002091 0.027503923 -1.126550265 FANK1 0 4 61 11.2430953 11.02851038 0.0002732 0.028312891 -1.10526252 DHX32 68521 2 8 11.2430953 11.02851038 0.0002732 0.028312891 -1.10526252 ADAM12 0 2 8 11.2430953 11.02851038 0.0002732 0.028312891 -1.10526252 FANK1 0 2 8 11.5383528 11.13275231 0.0003494 0.029177899 -1.171421429 AKR1E2 0 1 94 11.5383528 11.13275231 0.0003494 0.029177899 -1.171421429 AKR1C1 0 1 94 11.5383528 11.13275231 0.0003494 0.029177899 -1.171421429 AKR1C2 0 1 94 11.8173288 11.34762503 0.0006465 0.032591824 -1.184761866 AKR1E2 0 7 47 11.8173288 11.34762503 0.0006465 0.032591824 -1.184761866 AKR1C3 0 7 47 11.8173288 11.34762503 0.0006465 0.032591824 -1.184761866 AKR1C1 0 7 47 11.8173288 11.34762503 0.0006465 0.032591824 -1.184761866 AKR1C2 0 7 47 11.9549015 11.61294875 0.0003080 0.029009077 -1.14807721 AKR1C2 0 8 39 11.9549015 11.61294875 0.0003080 0.029009077 -1.14807721 AKR1C1 0 8 39 11.9549015 11.61294875 0.0003080 0.029009077 -1.14807721 AKR1C3 0 8 39 11.589351 11.36728472 0.0003834 0.029177899 -1.116741409 ANK3 62137 94 11.589351 11.36728472 0.0003834 0.029177899 -1.116741409 SLC16A9 8658 94 11.589351 11.36728472 0.0003834 0.029177899 -1.116741409 CCDC6 0 94 10.9388292 10.70231521 0.0006849 0.033273786 -1.100046215 SEC24C 0 3 96 10.9388292 10.70231521 0.0006849 0.033273786 -1.100046215 FUT11 2852 3 96 10.9388292 10.70231521 0.0006849 0.033273786 -1.100046215 AGAP5 0 3 96 11.2357313 10.98596584 0.0009141 0.034857276 -1.102212156 ZSWIM8 0 18 11.2357313 10.98596584 0.0009141 0.034857276 -1.102212156 NDST2 0 18 11.2357313 10.98596584 0.0009141 0.034857276 -1.102212156 FUT11 0 18 11.2357313 10.98596584 0.0009141 0.034857276 -1.102212156 RP11- 0 18 574K11.3 1 11.2357313 10.98596584 0.0009141 0.034857276 -1.102212156 CAMK2G 0 18 11.2357313 10.98596584 0.0009141 0.034857276 -1.102212156 AGAP5 0 18 11.2357313 10.98596584 0.0009141 0.034857276 -1.102212156 SEC24C 0 18 11.2357313 10.98596584 0.0009141 0.034857276 -1.102212156 CHCHD1 0 18 11.0916803 10.84948835 0.0007812 0.033565043 -1.101709133 CAMK2G 0 9 91 11.0916803 10.84948835 0.0007812 0.033565043 -1.101709133 CHCHD1 0 9 91 11.0916803 10.84948835 0.0007812 0.033565043 -1.101709133 SEC24C 0 9 91 11.0916803 10.84948835 0.0007812 0.033565043 -1.101709133 FUT11 0 9 91 11.0916803 10.84948835 0.0007812 0.033565043 -1.101709133 RP11- 0 9 91 574K11.3 1 11.0916803 10.84948835 0.0007812 0.033565043 -1.101709133 ZSWIM8 0 9 91 11.0916803 10.84948835 0.0007812 0.033565043 -1.101709133 NDST2 0 9 91 11.0916803 10.84948835 0.0007812 0.033565043 -1.101709133 AGAP5 0 9 91 11.3926536 11.1529215 0.0005852 0.032144622 -1.103405791 ART1 64382 6 46 11.3926536 11.1529215 0.0005852 0.032144622 -1.103405791 ART5 57757 6 46 11.3926536 11.1529215 0.0005852 0.032144622 -1.103405791 ZNF195 71223 6 46 11.0415481 10.83098545 0.0001283 0.027503923 -1.132102103 ART1 58776 56 11.0415481 10.83098545 0.0001283 0.027503923 -1.132102103 ART5 52151 56 11.0415481 10.83098545 0.0001283 0.027503923 -1.132102103 ZNF195 71223 56 11.4099240 11.24508649 0.0002576 0.028312891 -1.100822517 ART5 52151 1 61 11.4099240 11.24508649 0.0002576 0.028312891 -1.100822517 ZNF195 71223 1 61 11.4099240 11.24508649 0.0002576 0.028312891 -1.100822517 ART1 58776 1 61 11.4760946 11.20732973 0.0007600 0.033519117 -1.108741505 ART5 0 8 48 11.4760946 11.20732973 0.0007600 0.033519117 -1.108741505 CHRNA1 9978 8 48 0 11.4760946 11.20732973 0.0007600 0.033519117 -1.108741505 ART1 0 8 48 11.7983629 11.52601985 0.0002918 0.029009077 -1.137180406 CHRNA1 0 9 08 0 11.7983629 11.52601985 0.0002918 0.029009077 -1.137180406 ART1 0 9 08 11.7983629 11.52601985 0.0002918 0.029009077 -1.137180406 ART5 0 9 08 11.1652135 10.92939745 0.0002794 0.028813408 -1.116441364 OR4C12 201506 5 9 11.1652135 10.92939745 0.0002794 0.028813408 -1.116441364 FOLH1 975371 5 9 11.1652135 10.92939745 0.0002794 0.028813408 -1.116441364 OR4C13 230622 5 9 11.2228045 11.0798145 0.0006199 0.032219461 -1.103284722 MS4A10 0 7 02 11.2228045 11.0798145 0.0006199 0.032219461 -1.103284722 MS4A8 0 7 02 11.2228045 11.0798145 0.0006199 0.032219461 -1.103284722 MS4A18 0 7 02 11.2228045 11.0798145 0.0006199 0.032219461 -1.103284722 MS4A15 0 7 02 11.4177450 11.13291027 0.0009895 0.035439335 -1.11023185 ALDH3B1 8781 5 4 11.4177450 11.13291027 0.0009895 0.035439335 -1.11023185 NDUFS8 30820 5 4 11.4177450 11.13291027 0.0009895 0.035439335 -1.11023185 UNC93B 0 5 4 1 11.2599875 11.01391276 0.0005933 0.032219461 -1.104799616 UNC93B 0 4 28 1 11.2599875 11.01391276 0.0005933 0.032219461 -1.104799616 NDUFS8 21042 4 28 11.2599875 11.01391276 0.0005933 0.032219461 -1.104799616 ALDH3B1 0 4 28 11.0781901 10.92528925 0.0001373 0.027503923 -1.100723507 FCHSD2 0 25 11.0781901 10.92528925 0.0001373 0.027503923 -1.100723507 STARD10 116211 25 11.0781901 10.92528925 0.0001373 0.027503923 -1.100723507 ATG16L2 66705 25 11.7358397 11.51638463 0.0003791 0.029177899 -1.102401308 DLG2 0 6 6 11.7358397 11.51638463 0.0003791 0.029177899 -1.102401308 CCDC90 940477 6 6 B 11.7358397 11.51638463 0.0003791 0.029177899 -1.102401308 ANKRD4 966190 6 6 2 11.5909512 11.40883132 0.0001788 0.027503923 -1.101577503 NUP37 0 1 82 11.5909512 11.40883132 0.0001788 0.027503923 -1.101577503 PARPBP 0 1 82 11.5909512 11.40883132 0.0001788 0.027503923 -1.101577503 PMCH 0 1 82 11.7478898 11.37445297 0.0006998 0.033519117 -1.159479352 LRRK2 0 8 54 11.7478898 11.37445297 0.0006998 0.033519117 -1.159479352 CNTN1 236903 8 54 11.7478898 11.37445297 0.0006998 0.033519117 -1.159479352 SLC2A13 246838 8 54 11.6149818 11.39792289 0.0003671 0.029177899 -1.109893605 OR6C68 0 9 15 11.6149818 11.39792289 0.0003671 0.029177899 -1.109893605 OR6C4 0 9 15 11.6149818 11.39792289 0.0003671 0.029177899 -1.109893605 OR6C2 0 9 15 11.6149818 11.39792289 0.0003671 0.029177899 -1.109893605 OR2AP1 0 9 15 11.6149818 11.39792289 0.0003671 0.029177899 -1.109893605 OR6C76 0 9 15 11.6149818 11.39792289 0.0003671 0.029177899 -1.109893605 OR6C70 0 9 15 11.6149818 11.39792289 0.0003671 0.029177899 -1.109893605 OR10P1 0 9 15 11.5121966 11.33088052 0.0001773 0.027503923 -1.132019518 OR6C4 0 3 63 11.5121966 11.33088052 0.0001773 0.027503923 -1.132019518 OR6C68 0 3 63 11.5121966 11.33088052 0.0001773 0.027503923 -1.132019518 OR10P1 0 3 63 11.5121966 11.33088052 0.0001773 0.027503923 -1.132019518 OR2AP1 0 3 63 11.6225148 11.33938645 0.0004613 0.03019283 -1.125511435 OR10P1 0 4 46 11.6225148 11.33938645 0.0004613 0.03019283 -1.125511435 OR2AP1 5536 4 46 11.6225148 11.33938645 0.0004613 0.03019283 -1.125511435 OR6C4 28636 4 46 11.5668401 11.37153707 0.0001818 0.027503923 -1.108905881 ITGA7 682 3 2 11.5668401 11.37153707 0.0001818 0.027503923 -1.108905881 METTL7B 0 3 2 11.5668401 11.37153707 0.0001818 0.027503923 -1.108905881 OR10P1 7158 3 2 11.8541291 11.63530992 0.0007848 0.033598104 -1.105311941 ITGA7 0 3 65 11.8541291 11.63530992 0.0007848 0.033598104 -1.105311941 METTL7B 0 3 65 11.8541291 11.63530992 0.0007848 0.033598104 -1.105311941 BLOC1S1 0 3 65 11.8541291 11.63530992 0.0007848 0.033598104 -1.105311941 RDH5 0 3 65 11.8541291 11.63530992 0.0007848 0.033598104 -1.105311941 RP11- 0 3 65 644F5.10 11.8104562 11.26247207 0.0009952 0.035445898 -1.204754043 VWF 48341 6 06 11.8104562 11.26247207 0.0009952 0.035445898 -1.204754043 ANO2 0 6 06 11.8104562 11.26247207 0.0009952 0.035445898 -1.204754043 NTF3 196981 6 06 11.2767994 11.05611941 0.0001089 0.027503923 -1.12312569 ATP11A 11951 5 68 11.2767994 11.05611941 0.0001089 0.027503923 -1.12312569 ATP11AU 0 5 68 N 11.2767994 11.05611941 0.0001089 0.027503923 -1.12312569 TUBGCP 0 5 68 3 11.4088548 11.18873947 0.0002657 0.028312891 -1.110552739 TUBGCP 4797 9 69 3 11.4088548 11.18873947 0.0002657 0.028312891 -1.110552739 ATP11AU 0 9 69 N 11.4088548 11.18873947 0.0002657 0.028312891 -1.110552739 ATP11A 11951 9 69 11.6911756 11.35587132 0.0004927 0.030527112 -1.139759169 ATP11A 11951 4 08 11.6911756 11.35587132 0.0004927 0.030527112 -1.139759169 ATP11AU 0 4 08 N 11.6911756 11.35587132 0.0004927 0.030527112 -1.139759169 TUBGCP 18181 4 08 3 11.7657785 11.50584255 0.0003433 0.029177899 -1.116959463 TUBGCP 88711 1 21 3 11.7657785 11.50584255 0.0003433 0.029177899 -1.116959463 ATP11AU 0 1 21 N 11.7657785 11.50584255 0.0003433 0.029177899 -1.116959463 ATP11A 0 1 21 11.2743690 11.06371238 0.0005352 0.031253143 -1.119416227 ATP11AU 0 8 39 N 11.2743690 11.06371238 0.0005352 0.031253143 -1.119416227 ATP11A 0 8 39 11.2743690 11.06371238 0.0005352 0.031253143 -1.119416227 TUBGCP 88711 8 39 3 11.6007524 11.57333347 0.0008664 0.034559292 -1.101713112 CHAMP1 0 8 88 11.6007524 11.57333347 0.0008664 0.034559292 -1.101713112 CDC16 45053 8 88 11.6007524 11.57333347 0.0008664 0.034559292 -1.101713112 UPF3A 11959 8 88 11.8916303 11.61147833 0.0004658 0.030334659 -1.122762233 PCDH8 0 7 29 11.8916303 11.61147833 0.0004658 0.030334659 -1.122762233 OLFM4 0 7 29 11.8916303 11.61147833 0.0004658 0.030334659 -1.122762233 LECT1 78573 7 29 11.318202 11.03654673 0.0009029 0.034857276 -1.111762692 SPRY2 908045 8 11.318202 11.03654673 0.0009029 0.034857276 -1.111762692 RBM26 1842519 8 11.318202 11.03654673 0.0009029 0.034857276 -1.111762692 NDFIP2 1692921 8 11.2078091 10.95378288 0.0003128 0.029009077 -1.115604214 RBM26 2077313 4 61 11.2078091 10.95378288 0.0003128 0.029009077 -1.115604214 NDFIP2 1927715 4 61 11.2078091 10.95378288 0.0003128 0.029009077 -1.115604214 SPRY2 1142839 4 61 11.2479318 10.97902953 0.0008595 0.034488944 -1.108016465 NDFIP2 2127461 3 25 11.2479318 10.97902953 0.0008595 0.034488944 -1.108016465 SLITRK1 2137369 3 25 11.2479318 10.97902953 0.0008595 0.034488944 -1.108016465 SPRY2 1342585 3 25 10.9083088 10.74857567 9.5697E- 0.027503923 -1.107910134 CRIP1 832084 7 05 10.9083088 10.74857567 9.5697E- 0.027503923 -1.107910134 TMEM12 794149 7 05 1 10.9083088 10.74857567 9.5697E- 0.027503923 -1.107910134 C14orf80 824776 7 05 11.2468618 10.81911109 0.0004756 0.030334659 -1.173259405 TMEM12 819178 09 1 11.2468618 10.81911109 0.0004756 0.030334659 -1.173259405 CRIP1 857113 09 11.2468618 10.81911109 0.0004756 0.030334659 -1.173259405 C14orf80 849805 09 11.2371796 11.0388369 5.51648E- 0.027503923 -1.1405506 C14orf80 849805 5 05 11.2371796 11.0388369 5.51648E- 0.027503923 -1.1405506 TMEM12 819178 5 05 1 11.2371796 11.0388369 5.51648E- 0.027503923 -1.1405506 CRIP1 857113 5 05 11.6930053 11.36582196 0.0009300 0.034983012 -1.13344487 OR11H1 299766 2 82 2 11.6930053 11.36582196 0.0009300 0.034983012 -1.13344487 AL58974 375670 2 82 3.1 11.6930053 11.36582196 0.0009300 0.034983012 -1.13344487 POTEG 42927 2 82 11.8791007 11.5067407 0.0009833 0.035439335 -1.141657762 AL58974 0 2 51 3.1 11.8791007 11.5067407 0.0009833 0.035439335 -1.141657762 POTEM 0 2 51 11.8791007 11.5067407 0.0009833 0.035439335 -1.141657762 OR11H2 232757 2 51 12.0166272 11.78159244 0.0004948 0.030611554 -1.113759956 RP11- 0 5 87 176H8.1 12.0166272 11.78159244 0.0004948 0.030611554 -1.113759956 NUBPL 0 5 87 12.0166272 11.78159244 0.0004948 0.030611554 -1.113759956 GPR33 0 5 87 12.0166272 11.78159244 0.0004948 0.030611554 -1.113759956 DTD2 0 5 87 11.4722495 11.20928889 7.46955E- 0.027503923 -1.143840861 DTD2 93143 3 05 11.4722495 11.20928889 7.46955E- 0.027503923 -1.143840861 NUBPL 0 3 05 11.4722495 11.20928889 7.46955E- 0.027503923 -1.143840861 GPR33 62708 3 05 11.9299537 11.49742901 0.0007223 0.033519117 -1.17862212 PYGL 11673 3 98 11.9299537 11.49742901 0.0007223 0.033519117 -1.17862212 ABHD12 51439 3 98 B 11.9299537 11.49742901 0.0007223 0.033519117 -1.17862212 TRIM9 0 3 98 11.4598760 11.10470725 0.0007751 0.033519117 -1.138141838 AP5M1 19999 9 07 11.4598760 11.10470725 0.0007751 0.033519117 -1.138141838 NAA30 141634 9 07 11.4598760 11.10470725 0.0007751 0.033519117 -1.138141838 EXOC5 0 9 07 11.9731673 11.60224568 0.0008505 0.034374555 -1.144000806 EXOC5 0 56 11.9731673 11.60224568 0.0008505 0.034374555 -1.144000806 NAA30 141634 56 11.9731673 11.60224568 0.0008505 0.034374555 -1.144000806 AP5M1 19999 56 11.4845936 11.21086274 0.0005242 0.031122453 -1.125870241 SLC8A3 0 3 67 11.4845936 11.21086274 0.0005242 0.031122453 -1.125870241 SMOC1 0 3 67 11.4845936 11.21086274 0.0005242 0.031122453 -1.125870241 SLC10A1 106165 3 67 11.4708758 11.22555524 0.0003660 0.029177899 -1.119948391 SMOC1 0 8 09 11.4708758 11.22555524 0.0003660 0.029177899 -1.119948391 SLC8A3 0 8 09 11.4708758 11.22555524 0.0003660 0.029177899 -1.119948391 SLC10A1 106165 8 09 12.1236682 11.83198649 0.0008465 0.034347424 -1.116555787 SEMA7A 0 6 17 12.1236682 11.83198649 0.0008465 0.034347424 -1.116555787 UBL7 0 6 17 12.1236682 11.83198649 0.0008465 0.034347424 -1.116555787 CYP11A1 0 6 17 11.3785585 11.18263344 0.0001489 0.027503923 -1.107344363 CNTNAP 0 4 94 4 11.3785585 11.18263344 0.0001489 0.027503923 -1.107344363 RP11- 53394 4 94 58C22.1 11.3785585 11.18263344 0.0001489 0.027503923 -1.107344363 TERF2IP 616182 4 94 11.2770561 11.08428835 0.0001315 0.027503923 -1.128243024 MON1B 602734 5 33 11.2770561 11.08428835 0.0001315 0.027503923 -1.128243024 RP11- 0 5 33 58C22.1 11.2770561 11.08428835 0.0001315 0.027503923 -1.128243024 CNTNAP 0 5 33 4 11.4066005 11.16390197 0.0003622 0.029177899 -1.120616408 CNTNAP 0 9 65 4 11.4066005 11.16390197 0.0003622 0.029177899 -1.120616408 RP11- 0 9 65 58C22.1 11.4066005 11.16390197 0.0003622 0.029177899 -1.120616408 MON1B 602734 9 65 11.6126014 11.30534079 0.0009142 0.034857276 -1.11926089 UBALD2 7898 1 98 11.6126014 11.30534079 0.0009142 0.034857276 -1.11926089 RNF157 0 1 98 11.6126014 11.30534079 0.0009142 0.034857276 -1.11926089 QRICH2 16745 1 98 11.9033599 11.65205465 0.0006164 0.032219461 -1.106098343 ENTHD2 0 5 53 11.9033599 11.65205465 0.0006164 0.032219461 -1.106098343 TMEM10 0 5 53 5 11.9033599 11.65205465 0.0006164 0.032219461 -1.106098343 CEP131 0 5 53 11.9033599 11.65205465 0.0006164 0.032219461 -1.106098343 C17orf89 0 5 53 11.9033599 11.65205465 0.0006164 0.032219461 -1.106098343 SLC38A1 0 5 53 0 11.3547637 11.21934956 0.0001540 0.027503923 -1.104698202 GNAL 294931 3 4 11.3547637 11.21934956 0.0001540 0.027503923 -1.104698202 PIEZO2 196228 3 4 11.3547637 11.21934956 0.0001540 0.027503923 -1.104698202 CHMP1B 457371 3 4 11.6104239 11.37297034 0.0008672 0.034559292 -1.102253454 CHMP1B 395240 9 45 11.6104239 11.37297034 0.0008672 0.034559292 -1.102253454 GNAL 232800 9 45 11.6104239 11.37297034 0.0008672 0.034559292 -1.102253454 PIEZO2 196228 9 45 11.3268080 11.11654808 0.0001840 0.027503923 -1.121309717 CHMP1B 334425 8 2 11.3268080 11.11654808 0.0001840 0.027503923 -1.121309717 GNAL 171985 8 2 11.3268080 11.11654808 0.0001840 0.027503923 -1.121309717 PIEZO2 196228 8 2 11.5256702 11.34479678 8.59434E- 0.027503923 -1.127938832 ZBTB7C 148664 6 05 11.5256702 11.34479678 8.59434E- 0.027503923 -1.127938832 SKOR2 579300 6 05 11.5256702 11.34479678 8.59434E- 0.027503923 -1.127938832 SMAD2 0 6 05 11.0979242 10.90344329 0.0001813 0.027503923 -1.108871654 SALL3 0 26 11.0979242 10.90344329 0.0001813 0.027503923 -1.108871654 ATP9B 30418 26 11.0979242 10.90344329 0.0001813 0.027503923 -1.108871654 NFATC1 356989 26 11.7548834 11.67541011 0.0002689 0.028312891 -1.108648667 ELSPBP1 2120 4 24 11.7548834 11.67541011 0.0002689 0.028312891 -1.108648667 BSPH1 0 4 24 11.7548834 11.67541011 0.0002689 0.028312891 -1.108648667 CABP5 37422 4 24 11.7278814 11.60620284 0.0001290 0.027503923 -1.112735711 PLA2G4C 0 2 27 11.7278814 11.60620284 0.0001290 0.027503923 -1.112735711 ELSPBP1 0 2 27 11.7278814 11.60620284 0.0001290 0.027503923 -1.112735711 CABP5 0 2 27 11.7278814 11.60620284 0.0001290 0.027503923 -1.112735711 BSPH1 0 2 27 11.6709816 11.46151578 0.0001363 0.027503923 -1.11240172 ELAVL1 0 3 17 11.6709816 11.46151578 0.0001363 0.027503923 -1.11240172 RAB11B 0 3 17 11.6709816 11.46151578 0.0001363 0.027503923 -1.11240172 ANGPTL4 2116 3 17 10.9765526 10.69305774 0.0009737 0.035432488 -1.113929434 37316 0 2 46 10.9765526 10.69305774 0.0009737 0.035432488 -1.113929434 HNRNPM 0 2 46 10.9765526 10.69305774 0.0009737 0.035432488 -1.113929434 RAB11B 0 2 46 10.9765526 10.69305774 0.0009737 0.035432488 -1.113929434 ELAVL1 0 2 46 11.4597782 11.14456792 0.0004005 0.029177899 -1.133631254 RAB11B 0 15 11.4597782 11.14456792 0.0004005 0.029177899 -1.133631254 HNRNPM 0 15 11.4597782 11.14456792 0.0004005 0.029177899 -1.133631254 ELAVL1 0 15 11.4597782 11.14456792 0.0004005 0.029177899 -1.133631254 PRAM1 0 15 11.4597782 11.14456792 0.0004005 0.029177899 -1.133631254 37316 0 15 11.5022849 11.26743103 0.0002945 0.029009077 -1.127476991 ANKAR 0 4 36 11.5022849 11.26743103 0.0002945 0.029009077 -1.127476991 OSGEPL 0 4 36 1 11.5022849 11.26743103 0.0002945 0.029009077 -1.127476991 ASNSD1 0 4 36 11.6176805 11.43053933 0.0003842 0.029177899 -1.102768574 ASNSD1 0 2 17 11.6176805 11.43053933 0.0003842 0.029177899 -1.102768574 ANKAR 0 2 17 11.6176805 11.43053933 0.0003842 0.029177899 -1.102768574 OSGEPL 0 2 17 1 11.5672106 11.32483238 0.0004728 0.030334659 -1.116174289 ANKAR 0 5 63 11.5672106 11.32483238 0.0004728 0.030334659 -1.116174289 OSGEPL 0 5 63 1 11.5672106 11.32483238 0.0004728 0.030334659 -1.116174289 ASNSD1 7765 5 63 11.4172227 11.21519608 0.0002519 0.028312891 -1.108088464 OSGEPL 0 4 45 1 11.4172227 11.21519608 0.0002519 0.028312891 -1.108088464 ANKAR 0 4 45 11.4172227 11.21519608 0.0002519 0.028312891 -1.108088464 PMS1 0 4 45 11.4172227 11.21519608 0.0002519 0.028312891 -1.108088464 ORMDL1 0 4 45 11.5891129 11.33727925 0.0002436 0.028011377 -1.122344574 OSGEPL 0 8 19 1 11.5891129 11.33727925 0.0002436 0.028011377 -1.122344574 ANKAR 0 8 19 11.5891129 11.33727925 0.0002436 0.028011377 -1.122344574 ORMDL1 0 8 19 11.5891129 11.33727925 0.0002436 0.028011377 -1.122344574 PMS1 0 8 19 11.4693267 11.21411562 0.0006428 0.032591824 -1.121478122 ORMDL1 0 1 71 11.4693267 11.21411562 0.0006428 0.032591824 -1.121478122 PMS1 0 1 71 11.4693267 11.21411562 0.0006428 0.032591824 -1.121478122 C2orf88 0 1 71 11.4693267 11.21411562 0.0006428 0.032591824 -1.121478122 OSGEPL 0 1 71 1 11.4693267 11.21411562 0.0006428 0.032591824 -1.121478122 ANKAR 0 1 71 11.3885698 11.17439307 0.0005662 0.031680933 -1.110721373 C2orf88 0 6 44 11.3885698 11.17439307 0.0005662 0.031680933 -1.110721373 OSGEPL 0 6 44 1 11.3885698 11.17439307 0.0005662 0.031680933 -1.110721373 ORMDL1 0 6 44 11.3885698 11.17439307 0.0005662 0.031680933 -1.110721373 ANKAR 0 6 44 11.3885698 11.17439307 0.0005662 0.031680933 -1.110721373 PMS1 0 6 44 11.4408417 11.20059842 0.0001448 0.027503923 -1.127608074 ANKAR 0 4 87 11.4408417 11.20059842 0.0001448 0.027503923 -1.127608074 PMS1 0 4 87 11.4408417 11.20059842 0.0001448 0.027503923 -1.127608074 C2orf88 0 4 87 11.4408417 11.20059842 0.0001448 0.027503923 -1.127608074 ORMDL1 0 4 87 11.4408417 11.20059842 0.0001448 0.027503923 -1.127608074 OSGEPL 0 4 87 1 11.5573811 11.29497784 0.0006679 0.032989764 -1.117491716 ANKAR 0 5 11 11.5573811 11.29497784 0.0006679 0.032989764 -1.117491716 ORMDL1 0 5 11 11.5573811 11.29497784 0.0006679 0.032989764 -1.117491716 PMS1 0 5 11 11.5573811 11.29497784 0.0006679 0.032989764 -1.117491716 OSGEPL 0 5 11 1 11.5573811 11.29497784 0.0006679 0.032989764 -1.117491716 C2orf88 0 5 11 12.0585662 11.81560733 0.0001488 0.027503923 -1.139612022 ANKAR 0 8 5 12.0585662 11.81560733 0.0001488 0.027503923 -1.139612022 PMS1 0 8 5 12.0585662 11.81560733 0.0001488 0.027503923 -1.139612022 ORMDL1 0 8 5 12.0585662 11.81560733 0.0001488 0.027503923 -1.139612022 OSGEPL 0 8 5 1 12.0585662 11.81560733 0.0001488 0.027503923 -1.139612022 C2orf88 0 8 5 11.7701535 11.4682098 0.0004428 0.030116128 -1.142786566 C2orf88 0 6 39 11.7701535 11.4682098 0.0004428 0.030116128 -1.142786566 OSGEPL 0 6 39 1 11.7701535 11.4682098 0.0004428 0.030116128 -1.142786566 ORMDL1 0 6 39 11.7701535 11.4682098 0.0004428 0.030116128 -1.142786566 ANKAR 0 6 39 11.7701535 11.4682098 0.0004428 0.030116128 -1.142786566 PMS1 0 6 39 11.9694506 11.71415262 5.66334E- 0.027503923 -1.145415137 PMS1 0 7 05 11.9694506 11.71415262 5.66334E- 0.027503923 -1.145415137 ANKAR 0 7 05 11.9694506 11.71415262 5.66334E- 0.027503923 -1.145415137 ORMDL1 0 7 05 11.9694506 11.71415262 5.66334E- 0.027503923 -1.145415137 C2orf88 0 7 05 11.9694506 11.71415262 5.66334E- 0.027503923 -1.145415137 OSGEPL 0 7 05 1 11.547679 11.2706836 0.0002251 0.027503923 -1.133710498 MYO1B 0 92 11.547679 11.2706836 0.0002251 0.027503923 -1.133710498 STAT4 258235 92 11.547679 11.2706836 0.0002251 0.027503923 -1.133710498 NABP1 221519 92 11.6598414 11.35029356 0.0006810 0.033147726 -1.129176484 NABP1 221519 7 75 11.6598414 11.35029356 0.0006810 0.033147726 -1.129176484 STAT4 283230 7 75 11.6598414 11.35029356 0.0006810 0.033147726 -1.129176484 MYO1B 9437 7 75 11.6219534 11.35037499 0.0003714 0.029177899 -1.137406275 MYO1B 26919 7 11.6219534 11.35037499 0.0003714 0.029177899 -1.137406275 SDPR 229890 7 11.6219534 11.35037499 0.0003714 0.029177899 -1.137406275 NABP1 73656 7 11.3545421 11.11476572 0.0003064 0.029009077 -1.125241697 MYO1B 26919 5 19 11.3545421 11.11476572 0.0003064 0.029009077 -1.125241697 SDPR 229890 5 19 11.3545421 11.11476572 0.0003064 0.029009077 -1.125241697 NABP1 73656 5 19 11.6387652 11.3607613 0.0004488 0.030187579 -1.124907572 NABP1 44763 7 05 11.6387652 11.3607613 0.0004488 0.030187579 -1.124907572 SDPR 200997 7 05 11.6387652 11.3607613 0.0004488 0.030187579 -1.124907572 MYO1B 26919 7 05 11.2191050 10.98813286 0.0001504 0.027503923 -1.130436776 NABP1 26091 3 66 11.2191050 10.98813286 0.0001504 0.027503923 -1.130436776 MYO1B 26919 3 66 11.2191050 10.98813286 0.0001504 0.027503923 -1.130436776 SDPR 182325 3 66 11.6429510 11.44902352 0.0001241 0.027503923 -1.112262498 MYO1B 26919 5 02 11.6429510 11.44902352 0.0001241 0.027503923 -1.112262498 NABP1 15626 5 02 11.6429510 11.44902352 0.0001241 0.027503923 -1.112262498 SDPR 171860 5 02 11.6056240 11.34617238 0.0004510 0.03019283 -1.126459756 NABP1 15626 2 47 11.6056240 11.34617238 0.0004510 0.03019283 -1.126459756 SDPR 171860 2 47 11.6056240 11.34617238 0.0004510 0.03019283 -1.126459756 MYO1B 26919 2 47 11.3399694 11.119751 0.0005439 0.031360893 -1.124330696 ABCA12 20013 8 59 11.3399694 11.119751 0.0005439 0.031360893 -1.124330696 FN1 0 8 59 11.3399694 11.119751 0.0005439 0.031360893 -1.124330696 ATIC 0 8 59 11.6123244 11.37735238 0.0001930 0.027503923 -1.120164928 FN1 0 7 4 11.6123244 11.37735238 0.0001930 0.027503923 -1.120164928 ATIC 0 7 4 11.6123244 11.37735238 0.0001930 0.027503923 -1.120164928 ABCA12 20013 7 4 12.1206689 11.72769075 0.0003847 0.029177899 -1.169068818 DTNB 0 6 05 12.1206689 11.72769075 0.0003847 0.029177899 -1.169068818 DNMT3A 87755 6 05 12.1206689 11.72769075 0.0003847 0.029177899 -1.169068818 ASXL2 190380 6 05 12.0554495 11.66127496 0.0008684 0.034559292 -1.163753728 KIF3C 169353 8 28 12.0554495 11.66127496 0.0008684 0.034559292 -1.163753728 ASXL2 0 8 28 12.0554495 11.66127496 0.0008684 0.034559292 -1.163753728 DTNB 0 8 28 11.8039375 11.56107101 0.0003981 0.029177899 -1.110760938 LTBP1 201062 5 13 11.8039375 11.56107101 0.0003981 0.029177899 -1.110760938 RASGRP 35821 5 13 3 11.8039375 11.56107101 0.0003981 0.029177899 -1.110760938 FAM98A 1189 5 13 11.4396791 11.20787633 0.0002235 0.027503923 -1.136070605 CYP1B1 89668 13 11.4396791 11.20787633 0.0002235 0.027503923 -1.136070605 CDC42E 127606 13 P3 11.4396791 11.20787633 0.0002235 0.027503923 -1.136070605 RMDN2 0 13 11.3923309 11.18815931 0.0004815 0.030334659 -1.122290748 RMDN2 0 9 07 11.3923309 11.18815931 0.0004815 0.030334659 -1.122290748 CYP1B1 0 9 07 11.3923309 11.18815931 0.0004815 0.030334659 -1.122290748 ATL2 227579 9 07 11.0627344 10.81794708 0.0004731 0.030334659 -1.111792277 RMDN2 0 3 25 11.0627344 10.81794708 0.0004731 0.030334659 -1.111792277 CYP1B1 0 3 25 11.0627344 10.81794708 0.0004731 0.030334659 -1.111792277 ATL2 227579 3 25 12.0289581 11.74678341 0.0002017 0.027503923 -1.139239418 CYP1B1 0 8 94 12.0289581 11.74678341 0.0002017 0.027503923 -1.139239418 RMDN2 0 8 94 12.0289581 11.74678341 0.0002017 0.027503923 -1.139239418 ATL2 206689 8 94 11.4173388 11.15529457 0.0001029 0.027503923 -1.142413938 CYP1B1 0 9 5 11.4173388 11.15529457 0.0001029 0.027503923 -1.142413938 RMDN2 0 9 5 11.4173388 11.15529457 0.0001029 0.027503923 -1.142413938 ATL2 180587 9 5 12.0986904 11.84049294 0.0008829 0.034842626 -1.110907354 ATL2 180587 2 12 12.0986904 11.84049294 0.0008829 0.034842626 -1.110907354 RMDN2 0 2 12 12.0986904 11.84049294 0.0008829 0.034842626 -1.110907354 CYP1B1 0 2 12 11.4263426 11.18862175 0.0009840 0.035439335 -1.113415409 RMDN2 0 5 11.4263426 11.18862175 0.0009840 0.035439335 -1.113415409 CYP1B1 0 5 11.4263426 11.18862175 0.0009840 0.035439335 -1.113415409 ATL2 139405 5 11.4140683 11.17282641 0.0001293 0.027503923 -1.13464905 RMDN2 0 7 85 11.4140683 11.17282641 0.0001293 0.027503923 -1.13464905 ATL2 100533 7 85 11.4140683 11.17282641 0.0001293 0.027503923 -1.13464905 CYP1B1 0 7 85 12.0397537 11.76504687 9.02891E- 0.027503923 -1.144874371 RMDN2 0 8 05 12.0397537 11.76504687 9.02891E- 0.027503923 -1.144874371 ATL2 70887 8 05 12.0397537 11.76504687 9.02891E- 0.027503923 -1.144874371 CYP1B1 0 8 05 11.3305633 11.0900321 0.0007141 0.033519117 -1.122191198 ATL2 62789 2 84 11.3305633 11.0900321 0.0007141 0.033519117 -1.122191198 RMDN2 0 2 84 11.3305633 11.0900321 0.0007141 0.033519117 -1.122191198 CYP1B1 0 2 84 11.9321156 11.61694204 0.0004170 0.029783465 -1.146741243 REEP1 0 5 07 11.9321156 11.61694204 0.0004170 0.029783465 -1.146741243 PTCD3 0 5 07 11.9321156 11.61694204 0.0004170 0.029783465 -1.146741243 IMMT 0 5 07 11.9321156 11.61694204 0.0004170 0.029783465 -1.146741243 MRPL35 0 5 07 11.4989710 11.47298235 0.0008680 0.034559292 -1.136117322 TUBA8 0 7 47 11.4989710 11.47298235 0.0008680 0.034559292 -1.136117322 PEX26 0 7 47 11.4989710 11.47298235 0.0008680 0.034559292 -1.136117322 USP18 0 7 47 11.4048171 11.35423216 0.0003379 0.029177899 -1.159283856 PEX26 0 3 31 11.4048171 11.35423216 0.0003379 0.029177899 -1.159283856 TUBA8 0 3 31 11.4048171 11.35423216 0.0003379 0.029177899 -1.159283856 USP18 0 3 31 11.2739830 11.0073147 0.0001094 0.027503923 -1.136966179 TUBA8 9541 9 39 11.2739830 11.0073147 0.0001094 0.027503923 -1.136966179 PEX26 24957 9 39 11.2739830 11.0073147 0.0001094 0.027503923 -1.136966179 USP18 0 9 39 11.2531404 11.24000338 0.0009139 0.034857276 -1.161098601 PEX26 40925 9 86 11.2531404 11.24000338 0.0009139 0.034857276 -1.161098601 TUBA8 25509 9 86 11.2531404 11.24000338 0.0009139 0.034857276 -1.161098601 USP18 0 9 86 11.6298568 11.4293646 8.55304E- 0.027503923 -1.155930939 PEX26 55701 9 05 11.6298568 11.4293646 8.55304E- 0.027503923 -1.155930939 TUBA8 40285 9 05 11.6298568 11.4293646 8.55304E- 0.027503923 -1.155930939 USP18 9442 9 05 11.2732274 10.69145884 0.0008491 0.034374555 -1.223990492 USP18 34744 9 11 11.2732274 10.69145884 0.0008491 0.034374555 -1.223990492 TUBA8 65587 9 11 11.2732274 10.69145884 0.0008491 0.034374555 -1.223990492 PEX26 81003 9 11 11.5870022 11.40600109 0.0002267 0.027503923 -1.156554323 GGTLC3 132314 9 48 11.5870022 11.40600109 0.0002267 0.027503923 -1.156554323 USP18 169291 9 48 11.5870022 11.40600109 0.0002267 0.027503923 -1.156554323 TMEM19 143772 9 48 1B 11.4319331 11.20242746 3.88952E- 0.027503923 -1.154854155 GGTLC3 0 6 05 11.4319331 11.20242746 3.88952E- 0.027503923 -1.154854155 RIMBP3 85892 6 05 11.4319331 11.20242746 3.88952E- 0.027503923 -1.154854155 TMEM19 7879 6 05 1B 11.6315014 11.28854349 0.0005560 0.031459834 -1.155360276 TMEM19 0 1 1 1B 11.6315014 11.28854349 0.0005560 0.031459834 -1.155360276 RIMBP3 39316 1 1 11.6315014 11.28854349 0.0005560 0.031459834 -1.155360276 GGTLC3 0 1 1 10.9745287 10.82699385 9.66005E- 0.027503923 -1.159677233 RIMBP3 90104 5 05 10.9745287 10.82699385 9.66005E- 0.027503923 -1.159677233 TMEM19 12091 5 05 1B 10.9745287 10.82699385 9.66005E- 0.027503923 -1.159677233 GGTLC3 633 5 05 11.7796019 11.4826087 0.0006749 0.033115763 -1.119597955 GGTLC3 633 5 85 11.7796019 11.4826087 0.0006749 0.033115763 -1.119597955 RIMBP3 90104 5 85 11.7796019 11.4826087 0.0006749 0.033115763 -1.119597955 TMEM19 12091 5 85 1B 12.0092337 11.79045832 0.0003170 0.029020711 -1.104774402 RIMBP3 0 6 59 12.0092337 11.79045832 0.0003170 0.029020711 -1.104774402 TMEM19 0 6 59 1B 12.0092337 11.79045832 0.0003170 0.029020711 -1.104774402 GGTLC3 0 6 59 11.3546531 11.19032567 4.02118E- 0.027503923 -1.12732599 RIMBP3 0 05 11.3546531 11.19032567 4.02118E- 0.027503923 -1.12732599 GGTLC3 85403 05 11.3546531 11.19032567 4.02118E- 0.027503923 -1.12732599 TMEM19 72991 05 1B 11.1389196 11.11856197 0.0009979 0.03546495 -1.103589429 AC00732 0 5 84 6.1 11.1389196 11.11856197 0.0009979 0.03546495 -1.103589429 DGCR6 0 5 84 11.1389196 11.11856197 0.0009979 0.03546495 -1.103589429 DGCR2 0 5 84 11.1389196 11.11856197 0.0009979 0.03546495 -1.103589429 PRODH 0 5 84 10.9380318 10.63576213 5.46827E- 0.027503923 -1.190467918 PRODH 0 5 05 10.9380318 10.63576213 5.46827E- 0.027503923 -1.190467918 DGCR6 0 5 05 10.9380318 10.63576213 5.46827E- 0.027503923 -1.190467918 AC00732 23735 5 05 6.1 10.9136151 10.67241506 2.3492E- 0.027503923 -1.179860507 P2RX6 0 2 05 10.9136151 10.67241506 2.3492E- 0.027503923 -1.179860507 LRRC74B 0 2 05 10.9136151 10.67241506 2.3492E- 0.027503923 -1.179860507 LZTR1 0 2 05 10.9136151 10.67241506 2.3492E- 0.027503923 -1.179860507 AIFM3 0 2 05 10.9136151 10.67241506 2.3492E- 0.027503923 -1.179860507 SNAP29 0 2 05 10.9136151 10.67241506 2.3492E- 0.027503923 -1.179860507 PI4KA 0 2 05 10.9136151 10.67241506 2.3492E- 0.027503923 -1.179860507 THAP7 0 2 05 10.9136151 10.67241506 2.3492E- 0.027503923 -1.179860507 CRKL 0 2 05 10.9136151 10.67241506 2.3492E- 0.027503923 -1.179860507 SLC7A4 0 2 05 11.2302935 10.93766652 8.75734E- 0.027503923 -1.180313832 LRRC74B 0 5 05 11.2302935 10.93766652 8.75734E- 0.027503923 -1.180313832 P2RX6 0 5 05 11.2302935 10.93766652 8.75734E- 0.027503923 -1.180313832 AIFM3 0 5 05 11.2302935 10.93766652 8.75734E- 0.027503923 -1.180313832 CRKL 0 5 05 11.2302935 10.93766652 8.75734E- 0.027503923 -1.180313832 THAP7 0 5 05 11.2302935 10.93766652 8.75734E- 0.027503923 -1.180313832 LZTR1 0 5 05 11.2302935 10.93766652 8.75734E- 0.027503923 -1.180313832 SLC7A4 0 5 05 11.6544234 11.43181455 3.37879E- 0.027503923 -1.175508199 LRRC74B 55504 2 05 11.6544234 11.43181455 3.37879E- 0.027503923 -1.175508199 POM121 0 2 05 L7 11.6544234 11.43181455 3.37879E- 0.027503923 -1.175508199 GGT2 0 2 05 11.5726219 11.41288581 6.02184E- 0.027503923 -1.119126285 GGT2 0 8 05 11.5726219 11.41288581 6.02184E- 0.027503923 -1.119126285 LRRC74B 67934 8 05 11.5726219 11.41288581 6.02184E- 0.027503923 -1.119126285 POM121 4039 8 05 L7 11.5442630 11.43559453 0.0001087 0.027503923 -1.112910996 GGT2 0 8 06 11.5442630 11.43559453 0.0001087 0.027503923 -1.112910996 POM121 4039 8 06 L7 11.5442630 11.43559453 0.0001087 0.027503923 -1.112910996 LRRC74B 67934 8 06 11.2867281 11.24415915 0.0005814 0.032085851 -1.154841094 POM121 41890 1 03 L7 11.2867281 11.24415915 0.0005814 0.032085851 -1.154841094 GGT2 0 1 03 11.2867281 11.24415915 0.0005814 0.032085851 -1.154841094 RIMBP3B 81650 1 03 11.2563974 10.76311171 0.0007975 0.033727227 -1.187878884 ZNF280A 0 9 34 11.2563974 10.76311171 0.0007975 0.033727227 -1.187878884 GGTLC2 0 9 34 11.2563974 10.76311171 0.0007975 0.033727227 -1.187878884 PRAME 0 9 34 11.2563974 10.76311171 0.0007975 0.033727227 -1.187878884 ZNF280B 0 9 34 11.8923534 11.53926038 0.0003746 0.029177899 -1.149998207 PRAME 0 9 66 11.8923534 11.53926038 0.0003746 0.029177899 -1.149998207 GGTLC2 0 9 66 11.8923534 11.53926038 0.0003746 0.029177899 -1.149998207 ZNF280B 0 9 66 11.8923534 11.53926038 0.0003746 0.029177899 -1.149998207 ZNF280A 0 9 66 11.5267031 11.01909912 0.0007089 0.033519117 -1.196053387 IGLL5 62492 3 49 11.5267031 11.01909912 0.0007089 0.033519117 -1.196053387 GGTLC2 0 3 49 11.5267031 11.01909912 0.0007089 0.033519117 -1.196053387 PRAME 85117 3 49 11.9239546 11.56552064 0.0007395 0.033519117 -1.147252224 GGTLC2 0 6 09 11.9239546 11.56552064 0.0007395 0.033519117 -1.147252224 IGLL5 37210 6 09 11.9239546 11.56552064 0.0007395 0.033519117 -1.147252224 PRAME 85117 6 09 11.4833431 10.92841513 0.0009660 0.035358816 -1.207245518 PRAME 85117 3 6 11.4833431 10.92841513 0.0009660 0.035358816 -1.207245518 IGLL5 0 3 6 11.4833431 10.92841513 0.0009660 0.035358816 -1.207245518 GGTLC2 0 3 6 11.6679063 11.15401305 0.0009508 0.03529431 -1.194935823 GGTLC2 0 6 28 11.6679063 11.15401305 0.0009508 0.03529431 -1.194935823 PRAME 85117 6 28 11.6679063 11.15401305 0.0009508 0.03529431 -1.194935823 IGLL5 0 6 28 10.9775639 10.47156603 0.0003844 0.029177899 -1.213923843 GGT1 0 5 67 10.9775639 10.47156603 0.0003844 0.029177899 -1.213923843 SNRPD3 16234 5 67 10.9775639 10.47156603 0.0003844 0.029177899 -1.213923843 LRRC75B 33006 5 67 11.2916276 10.7679017 0.0009840 0.035439335 -1.196910486 GGT1 0 9 81 11.2916276 10.7679017 0.0009840 0.035439335 -1.196910486 SNRPD3 16234 9 81 11.2916276 10.7679017 0.0009840 0.035439335 -1.196910486 PIWIL3 0 9 81 11.3594742 11.12322792 0.0001134 0.027503923 -1.123478791 GGT1 20755 8 1 11.3594742 11.12322792 0.0001134 0.027503923 -1.123478791 PIWIL3 0 8 1 11.3594742 11.12322792 0.0001134 0.027503923 -1.123478791 SGSM1 0 8 1 11.6657141 11.41798737 0.0003883 0.029177899 -1.111141587 TMEM14 0 6 08 E 11.6657141 11.41798737 0.0003883 0.029177899 -1.111141587 SUCNR1 333409 6 08 11.6657141 11.41798737 0.0003883 0.029177899 -1.111141587 MBNL1 0 6 08 11.9216218 11.69210414 0.0005098 0.031010896 -1.118143895 DGKG 0 5 19 11.9216218 11.69210414 0.0005098 0.031010896 -1.118143895 ETV5 86041 5 19 11.9216218 11.69210414 0.0005098 0.031010896 -1.118143895 CRYGS 103141 5 19 11.4870433 11.27438814 0.0001118 0.027503923 -1.126605145 CRYGS 76430 7 92 11.4870433 11.27438814 0.0001118 0.027503923 -1.126605145 TBCCD1 84062 7 92 11.4870433 11.27438814 0.0001118 0.027503923 -1.126605145 DGKG 68138 7 92 11.5080927 11.26622053 0.0002720 0.028312891 -1.11801371 CRYGS 0 1 44 11.5080927 11.26622053 0.0002720 0.028312891 -1.11801371 TBCCD1 0 1 44 11.5080927 11.26622053 0.0002720 0.028312891 -1.11801371 DNAJB11 0 1 44 11.9591123 11.71222113 0.0001664 0.027503923 -1.150142129 TM4SF19 0 48 - TCTEX1D 2 11.9591123 11.71222113 0.0001664 0.027503923 -1.150142129 TCTEX1D 0 48 2 11.9591123 11.71222113 0.0001664 0.027503923 -1.150142129 PCYT1A 0 48 11.9591123 11.71222113 0.0001664 0.027503923 -1.150142129 TM4SF19 0 48 11.9591123 11.71222113 0.0001664 0.027503923 -1.150142129 RP11- 0 48 447L10.1 12.0694221 11.65988659 0.0008512 0.034374555 -1.162668645 ARL8B 0 4 83 12.0694221 11.65988659 0.0008512 0.034374555 -1.162668645 BHLHE40 0 4 83 12.0694221 11.65988659 0.0008512 0.034374555 -1.162668645 EDEM1 0 4 83 11.9340323 11.53938709 0.0006470 0.032591824 -1.168441699 ARL8B 0 2 66 11.9340323 11.53938709 0.0006470 0.032591824 -1.168441699 EDEM1 0 2 66 11.9340323 11.53938709 0.0006470 0.032591824 -1.168441699 BHLHE40 150685 2 66 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 GPR62 0 7 3 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 RP11- 0 7 3 155D18. 12 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 ABHD14 0 7 3 A 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 PARP3 0 7 3 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 IQCF2 0 7 3 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 IQCF5 0 7 3 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 ABHD14 0 7 3 A-ACY1 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 IQCF1 0 7 3 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 ABHD14 0 7 3 B 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 RRP9 0 7 3 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 PCBP4 0 7 3 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 ACY1 0 7 3 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 RPL29 0 7 3 11.0015072 10.72534021 0.0008455 0.034347424 -1.109638813 IQCF3 0 7 3 11.343938 11.06092734 0.0003941 0.029177899 -1.124718482 RP11- 0 64 155D18. 12 11.343938 11.06092734 0.0003941 0.029177899 -1.124718482 IQCF5 0 64 11.343938 11.06092734 0.0003941 0.029177899 -1.124718482 ABHD14 0 64 A-ACY1 11.343938 11.06092734 0.0003941 0.029177899 -1.124718482 IQCF1 0 64 11.343938 11.06092734 0.0003941 0.029177899 -1.124718482 ABHD14 0 64 A 11.343938 11.06092734 0.0003941 0.029177899 -1.124718482 PARP3 0 64 11.343938 11.06092734 0.0003941 0.029177899 -1.124718482 RPL29 0 64 11.343938 11.06092734 0.0003941 0.029177899 -1.124718482 RRP9 0 64 11.343938 11.06092734 0.0003941 0.029177899 -1.124718482 PCBP4 0 64 11.343938 11.06092734 0.0003941 0.029177899 -1.124718482 ABHD14 0 64 B 11.343938 11.06092734 0.0003941 0.029177899 -1.124718482 GPR62 0 64 11.343938 11.06092734 0.0003941 0.029177899 -1.124718482 ACY1 0 64 11.3799683 11.03767078 0.0007756 0.033519117 -1.14078371 RPL29 0 6 88 11.3799683 11.03767078 0.0007756 0.033519117 -1.14078371 DUSP7 0 6 88 11.3799683 11.03767078 0.0007756 0.033519117 -1.14078371 POC1A 0 6 88 11.8998654 11.59694317 0.0006451 0.032591824 -1.12273913 HS3ST1 488637 3 98 11.8998654 11.59694317 0.0006451 0.032591824 -1.12273913 CLNK 1233537 3 98 11.8998654 11.59694317 0.0006451 0.032591824 -1.12273913 RAB28 1312741 3 98 11.4424259 11.16754007 0.0008317 0.034211445 -1.109712519 CLNK 1233537 12 11.4424259 11.16754007 0.0008317 0.034211445 -1.109712519 HS3ST1 488637 12 11.4424259 11.16754007 0.0008317 0.034211445 -1.109712519 RAB28 1291575 12 11.0850985 10.77155941 0.0004034 0.02931647 -1.13468913 FRG1 704232 02 11.0850985 10.77155941 0.0004034 0.02931647 -1.13468913 FRG2 787795 02 11.0850985 10.77155941 0.0004034 0.02931647 -1.13468913 DUX4 937218 02 10.9703622 10.72994521 0.0001098 0.027503923 -1.139643476 OTOP1 0 1 23 10.9703622 10.72994521 0.0001098 0.027503923 -1.139643476 LYAR 0 1 23 10.9703622 10.72994521 0.0001098 0.027503923 -1.139643476 ZBTB49 0 1 23 10.9703622 10.72994521 0.0001098 0.027503923 -1.139643476 TMEM12 0 1 23 8 11.4346070 11.13307145 0.0005537 0.031459834 -1.132426637 FAM170A 406996 9 43 11.4346070 11.13307145 0.0005537 0.031459834 -1.132426637 PRR16 316023 9 43 11.4346070 11.13307145 0.0005537 0.031459834 -1.132426637 HSD17B4 405619 9 43 11.2635994 11.07355053 0.0002079 0.027503923 -1.104685867 SGCD 0 7 45 11.2635994 11.07355053 0.0002079 0.027503923 -1.104685867 AC01657 0 7 45 7.1 11.2635994 11.07355053 0.0002079 0.027503923 -1.104685867 TIMD4 260592 7 45 11.5387972 11.32428849 0.0002218 0.027503923 -1.118753813 SCGB3A 59072 7 73 1 11.5387972 11.32428849 0.0002218 0.027503923 -1.118753813 CNOT6 0 7 73 11.5387972 11.32428849 0.0002218 0.027503923 -1.118753813 FLT4 70475 7 73 11.3833655 11.19872989 0.0003688 0.029177899 -1.112423947 SCGB3A 19949 6 17 1 11.3833655 11.19872989 0.0003688 0.029177899 -1.112423947 FLT4 31352 6 17 11.3833655 11.19872989 0.0003688 0.029177899 -1.112423947 CNOT6 0 6 17 11.8569764 11.56651603 0.0004380 0.02999776 -1.131768894 CNOT6 0 1 58 11.8569764 11.56651603 0.0004380 0.02999776 -1.131768894 SCGB3A 0 1 58 1 11.8569764 11.56651603 0.0004380 0.02999776 -1.131768894 FLT4 0 1 58 11.6277012 11.36000323 0.0005312 0.031201337 -1.115897221 SCGB3A 0 1 55 1 11.6277012 11.36000323 0.0005312 0.031201337 -1.115897221 FLT4 0 1 55 11.6277012 11.36000323 0.0005312 0.031201337 -1.115897221 CNOT6 0 1 55 11.3999505 11.17720608 0.0004512 0.03019283 -1.104832684 PRDM9 245261 5 32 11.3999505 11.17720608 0.0004512 0.03019283 -1.104832684 CDH10 535599 5 32 11.3999505 11.17720608 0.0004512 0.03019283 -1.104832684 CDH12 920236 5 32 11.6070259 11.39570228 0.0003464 0.029177899 -1.112208174 SNX18 97255 3 33 11.6070259 11.39570228 0.0003464 0.029177899 -1.112208174 ARL15 0 3 33 11.6070259 11.39570228 0.0003464 0.029177899 -1.112208174 HSPB3 35097 3 33 11.4143903 11.18660983 0.0003888 0.029177899 -1.132323558 SNX18 97255 5 64 11.4143903 11.18660983 0.0003888 0.029177899 -1.132323558 HSPB3 35097 5 64 11.4143903 11.18660983 0.0003888 0.029177899 -1.132323558 ARL15 0 5 64 11.6996492 11.46052722 0.0009436 0.035221009 -1.105438805 HSPB3 35097 5 88 11.6996492 11.46052722 0.0009436 0.035221009 -1.105438805 SNX18 97255 5 88 11.6996492 11.46052722 0.0009436 0.035221009 -1.105438805 ARL15 2138 5 88 11.3897495 11.17370419 0.0001182 0.027503923 -1.118976853 SNX18 97255 2 13 11.3897495 11.17370419 0.0001182 0.027503923 -1.118976853 HSPB3 35097 2 13 11.3897495 11.17370419 0.0001182 0.027503923 -1.118976853 ARL15 83591 2 13 11.5269024 11.28521617 0.0004722 0.030334659 -1.116019666 HSPB3 6797 4 04 11.5269024 11.28521617 0.0004722 0.030334659 -1.116019666 ARL15 99354 4 04 11.5269024 11.28521617 0.0004722 0.030334659 -1.116019666 SNX18 68955 4 04 11.3557157 11.12964051 0.0007167 0.033519117 -1.108116391 SNX18 54290 2 49 11.3557157 11.12964051 0.0007167 0.033519117 -1.108116391 ARL15 99354 2 49 11.3557157 11.12964051 0.0007167 0.033519117 -1.108116391 HSPB3 0 2 49 11.5362853 11.29216093 0.0002884 0.029009077 -1.124162486 HSPB3 0 2 39 11.5362853 11.29216093 0.0002884 0.029009077 -1.124162486 ARL15 99354 2 39 11.5362853 11.29216093 0.0002884 0.029009077 -1.124162486 SNX18 53150 2 39 12.0938881 11.84654923 0.0007663 0.033519117 -1.102672453 SNX18 0 2 39 12.0938881 11.84654923 0.0007663 0.033519117 -1.102672453 HSPB3 0 2 39 12.0938881 11.84654923 0.0007663 0.033519117 -1.102672453 ARL15 99354 2 39 11.9147494 11.68967013 0.0003812 0.029177899 -1.110293057 SNX18 0 54 11.9147494 11.68967013 0.0003812 0.029177899 -1.110293057 ARL15 99354 54 11.9147494 11.68967013 0.0003812 0.029177899 -1.110293057 HSPB3 0 54 11.5387308 11.27341852 0.0001128 0.027503923 -1.141178081 SNX18 0 8 79 11.5387308 11.27341852 0.0001128 0.027503923 -1.141178081 ARL15 99354 8 79 11.5387308 11.27341852 0.0001128 0.027503923 -1.141178081 HSPB3 0 8 79 11.3617145 11.12340661 0.0002169 0.027503923 -1.124534964 HSPB3 0 7 49 11.3617145 11.12340661 0.0002169 0.027503923 -1.124534964 ARL15 99354 7 49 11.3617145 11.12340661 0.0002169 0.027503923 -1.124534964 SNX18 0 7 49 11.3771275 11.12925044 0.0002663 0.028312891 -1.12751881 HSPB3 0 5 3 11.3771275 11.12925044 0.0002663 0.028312891 -1.12751881 ARL15 99354 5 3 11.3771275 11.12925044 0.0002663 0.028312891 -1.12751881 SNX18 0 5 3 11.4586157 11.22019789 0.0002187 0.027503923 -1.117323814 ARL15 99354 5 07 11.4586157 11.22019789 0.0002187 0.027503923 -1.117323814 SNX18 0 5 07 11.4586157 11.22019789 0.0002187 0.027503923 -1.117323814 HSPB3 0 5 07 12.0633143 11.81975468 0.0001022 0.027503923 -1.133253119 HSPB3 0 53 12.0633143 11.81975468 0.0001022 0.027503923 -1.133253119 ARL15 99354 53 12.0633143 11.81975468 0.0001022 0.027503923 -1.133253119 SNX18 0 53 11.6537038 11.39604793 0.0009545 0.03529431 -1.107468457 SNX18 0 54 11.6537038 11.39604793 0.0009545 0.03529431 -1.107468457 ARL15 99354 54 11.6537038 11.39604793 0.0009545 0.03529431 -1.107468457 HSPB3 0 54 11.4016203 11.18930086 0.0001062 0.027503923 -1.12118865 HSPB3 0 8 96 11.4016203 11.18930086 0.0001062 0.027503923 -1.12118865 SNX18 0 8 96 11.4016203 11.18930086 0.0001062 0.027503923 -1.12118865 ARL15 99354 8 96 11.1780907 10.87889073 0.0009182 0.034857276 -1.120691789 PDE4D 0 5 01 11.1780907 10.87889073 0.0009182 0.034857276 -1.120691789 DEPDC1 108401 5 01 B 11.1780907 10.87889073 0.0009182 0.034857276 -1.120691789 FKSG52 0 5 01 11.2698936 10.91673054 0.0006025 0.032219461 -1.142125645 RANBP9 110548 2 23 11.2698936 10.91673054 0.0006025 0.032219461 -1.142125645 MCUR1 7544 2 23 11.2698936 10.91673054 0.0006025 0.032219461 -1.142125645 RNF182 0 2 23 11.6865267 11.30340221 0.0004319 0.029939725 -1.162591844 MCUR1 135079 7 35 11.6865267 11.30340221 0.0004319 0.029939725 -1.162591844 RNF182 0 7 35 11.6865267 11.30340221 0.0004319 0.029939725 -1.162591844 CD83 98735 7 35 11.7166437 11.27609364 0.0005483 0.031459834 -1.187013964 ZNF391 0 7 04 11.7166437 11.27609364 0.0005483 0.031459834 -1.187013964 POM121 61204 7 04 L2 11.7166437 11.27609364 0.0005483 0.031459834 -1.187013964 ZNF184 16239 7 04 11.1752246 10.73229154 0.0009353 0.035030527 -1.175067655 ZNF391 21100 3 27 11.1752246 10.73229154 0.0009353 0.035030527 -1.175067655 ZNF184 1286 3 27 11.1752246 10.73229154 0.0009353 0.035030527 -1.175067655 POM121 112834 3 27 L2 11.3040139 11.08116 0.0006234 0.032269716 -1.114749021 ZBED9 49120 2 51 11.3040139 11.08116 0.0006234 0.032269716 -1.114749021 GPX5 3415 2 51 11.3040139 11.08116 0.0006234 0.032269716 -1.114749021 GPX6 0 2 51 11.4056277 11.18036126 0.0001429 0.027503923 -1.123573076 GPX5 0 9 64 11.4056277 11.18036126 0.0001429 0.027503923 -1.123573076 GPX6 0 9 64 11.4056277 11.18036126 0.0001429 0.027503923 -1.123573076 ZBED9 11156 9 64 11.4859942 11.12974157 0.0005684 0.031733878 -1.154724009 HLA-A 39088 5 6 11.4859942 11.12974157 0.0005684 0.031733878 -1.154724009 HLA-G 0 5 6 11.4859942 11.12974157 0.0005684 0.031733878 -1.154724009 HLA-F 569 5 6 10.9414779 10.7287413 0.0003703 0.029177899 -1.123448547 UNC5CL 0 1 51 10.9414779 10.7287413 0.0003703 0.029177899 -1.123448547 TSPO2 9999 1 51 10.9414779 10.7287413 0.0003703 0.029177899 -1.123448547 OARD1 1072 1 51 12.0647274 11.77221674 0.0004351 0.029939725 -1.128624759 LHFPL3 0 4 04 12.0647274 11.77221674 0.0004351 0.029939725 -1.128624759 KMT2E 248025 4 04 12.0647274 11.77221674 0.0004351 0.029939725 -1.128624759 SRPK2 344550 4 04 11.3040400 11.09500347 0.0004201 0.029841706 -1.111649438 LHFPL3 0 5 71 11.3040400 11.09500347 0.0004201 0.029841706 -1.111649438 KMT2E 248025 5 71 11.3040400 11.09500347 0.0004201 0.029841706 -1.111649438 SRPK2 344550 5 71 11.1151478 10.75851919 0.0001661 0.027503923 -1.16434164 FAM86B2 168210 4 03 11.1151478 10.75851919 0.0001661 0.027503923 -1.16434164 LONRF1 0 4 03 11.1151478 10.75851919 0.0001661 0.027503923 -1.16434164 KIAA1456 212031 4 03 11.4284386 11.1990194 0.0007067 0.033519117 -1.123068746 SH2D4A 0 18 11.4284386 11.1990194 0.0007067 0.033519117 -1.123068746 CSGALN 0 18 ACT1 11.4284386 11.1990194 0.0007067 0.033519117 -1.123068746 PSD3 198697 18 11.3978869 11.12210558 0.0005309 0.031201337 -1.117669501 WRN 202735 6 3 11.3978869 11.12210558 0.0005309 0.031201337 -1.117669501 NRG1 140772 6 3 11.3978869 11.12210558 0.0005309 0.031201337 -1.117669501 PURG 342789 6 3 11.5107112 11.23739979 0.0001100 0.027503923 -1.145563681 USP17L4 0 3 37 11.5107112 11.23739979 0.0001100 0.027503923 -1.145563681 USP17L1 0 3 37 11.5107112 11.23739979 0.0001100 0.027503923 -1.145563681 ZNF705G 0 3 37 11.1289168 10.7870736 9.11143E- 0.027503923 -1.167252218 ZNF705G 0 4 05 11.1289168 10.7870736 9.11143E- 0.027503923 -1.167252218 USP17L4 0 4 05 11.1289168 10.7870736 9.11143E- 0.027503923 -1.167252218 USP17L1 0 4 05 11.0961976 10.73295019 8.41232E- 0.027503923 -1.178023105 DEFB103 0 6 05 B 11.0961976 10.73295019 8.41232E- 0.027503923 -1.178023105 DEFB104 0 6 05 B 11.0961976 10.73295019 8.41232E- 0.027503923 -1.178023105 SPAG11B 0 6 05 11.0961976 10.73295019 8.41232E- 0.027503923 -1.178023105 USP17L4 0 6 05 11.0961976 10.73295019 8.41232E- 0.027503923 -1.178023105 DEFB4B 0 6 05 11.0961976 10.73295019 8.41232E- 0.027503923 -1.178023105 ZNF705G 0 6 05 11.0961976 10.73295019 8.41232E- 0.027503923 -1.178023105 USP17L1 0 6 05 11.1824728 10.81410841 0.0001669 0.027503923 -1.168778144 DEFB107 27401 2 02 A 11.1824728 10.81410841 0.0001669 0.027503923 -1.168778144 DEFB105 37647 2 02 A 11.1824728 10.81410841 0.0001669 0.027503923 -1.168778144 PRR23D2 0 2 02 11.9471992 11.69552745 0.0002299 0.027503923 -1.135054009 FSBP 5635 8 2 11.9471992 11.69552745 0.0002299 0.027503923 -1.135054009 RAD54B 0 8 2 11.9471992 11.69552745 0.0002299 0.027503923 -1.135054009 GEM 78820 8 2 11.4855898 11.25926026 0.0001905 0.027503923 -1.117379339 GEM 78820 7 67 11.4855898 11.25926026 0.0001905 0.027503923 -1.117379339 FSBP 0 7 67 11.4855898 11.25926026 0.0001905 0.027503923 -1.117379339 RAD54B 0 7 67 12.0138231 11.72450218 0.0007360 0.033519117 -1.119303069 FSBP 0 8 06 12.0138231 11.72450218 0.0007360 0.033519117 -1.119303069 RAD54B 0 8 06 12.0138231 11.72450218 0.0007360 0.033519117 -1.119303069 KIAA1429 69001 8 06 11.2596285 11.01989 0.0008986 0.034857276 -1.102699156 RAD54B 0 15 11.2596285 11.01989 0.0008986 0.034857276 -1.102699156 KIAA1429 51013 15 11.2596285 11.01989 0.0008986 0.034857276 -1.102699156 FSBP 0 15 11.4401279 11.21405383 0.0007472 0.033519117 -1.110728074 KIAA1429 37017 7 67 11.4401279 11.21405383 0.0007472 0.033519117 -1.110728074 FSBP 0 7 67 11.4401279 11.21405383 0.0007472 0.033519117 -1.110728074 RAD54B 0 7 67 11.6285118 11.36609737 0.0008308 0.034211445 -1.110442438 FSBP 0 3 67 11.6285118 11.36609737 0.0008308 0.034211445 -1.110442438 KIAA1429 27740 3 67 11.6285118 11.36609737 0.0008308 0.034211445 -1.110442438 RAD54B 0 3 67 11.3341886 11.05802571 0.0005386 0.031253143 -1.116182885 RP11- 0 4 11 195F19.5 11.3341886 11.05802571 0.0005386 0.031253143 -1.116182885 CCL27 0 4 11 11.3341886 11.05802571 0.0005386 0.031253143 -1.116182885 RP11- 0 4 11 195F19.2 9 11.3341886 11.05802571 0.0005386 0.031253143 -1.116182885 IL11RA 0 4 11 11.3341886 11.05802571 0.0005386 0.031253143 -1.116182885 CCL19 0 4 11 11.3341886 11.05802571 0.0005386 0.031253143 -1.116182885 CCL21 0 4 11 11.3341886 11.05802571 0.0005386 0.031253143 -1.116182885 FAM205A 0 4 11 11.3341886 11.05802571 0.0005386 0.031253143 -1.116182885 SIGMAR1 0 4 11 11.3341886 11.05802571 0.0005386 0.031253143 -1.116182885 GALT 0 4 11 11.4882421 11.24235571 0.0002408 0.027873856 -1.1260804 SHB 0 3 11.4882421 11.24235571 0.0002408 0.027873856 -1.1260804 RP11- 0 3 613M10. 9 11.4882421 11.24235571 0.0002408 0.027873856 -1.1260804 SLC25A5 0 3 1 11.9360784 11.64152601 0.0001903 0.027503923 -1.148601311 SHB 0 61 11.9360784 11.64152601 0.0001903 0.027503923 -1.148601311 SLC25A5 0 61 1 11.9360784 11.64152601 0.0001903 0.027503923 -1.148601311 RP11- 0 61 613M10. 9 11.3894714 11.22565608 0.0003978 0.029177899 -1.101309696 SHB 0 3 05 11.3894714 11.22565608 0.0003978 0.029177899 -1.101309696 SLC25A5 0 3 05 1 11.3894714 11.22565608 0.0003978 0.029177899 -1.101309696 RP11- 0 3 05 613M10. 9 11.7585143 11.49234929 0.0006135 0.032219461 -1.12683339 SHB 0 31 11.7585143 11.49234929 0.0006135 0.032219461 -1.12683339 RP11- 0 31 613M10. 9 11.7585143 11.49234929 0.0006135 0.032219461 -1.12683339 SLC25A5 0 31 1 11.666233 11.45653923 0.0007497 0.033519117 -1.102956268 SLC25A5 0 02 1 11.666233 11.45653923 0.0007497 0.033519117 -1.102956268 RP11- 0 02 613M10. 9 11.666233 11.45653923 0.0007497 0.033519117 -1.102956268 SHB 0 02 11.6214949 11.33453985 0.0005147 0.031122453 -1.128973836 DMRT1 0 6 94 11.6214949 11.33453985 0.0005147 0.031122453 -1.128973836 KANK1 0 6 94 11.6214949 11.33453985 0.0005147 0.031122453 -1.128973836 DMRT3 115437 6 94 11.2650240 11.02649409 0.0004608 0.03019283 -1.112471029 DMRT2 67928 8 39 11.2650240 11.02649409 0.0004608 0.03019283 -1.112471029 DMRT3 0 8 39 11.2650240 11.02649409 0.0004608 0.03019283 -1.112471029 DMRT1 0 8 39 11.6981180 11.3838914 0.0008422 0.034347424 -1.122244983 ERCC6L2 192054 5 86 11.6981180 11.3838914 0.0008422 0.034347424 -1.122244983 FANCC 259092 5 86 11.6981180 11.3838914 0.0008422 0.034347424 -1.122244983 PTCH1 59744 5 86 12.0814659 11.66836022 0.0005972 0.032219461 -1.163577562 BEX4 0 43 12.0814659 11.66836022 0.0005972 0.032219461 -1.163577562 TCEAL8 36656 43 12.0814659 11.66836022 0.0005972 0.032219461 -1.163577562 NXF3 12273 43 11.6995050 11.40140373 0.0007546 0.033519117 -1.118345985 KIAA1210 17052 8 54 11.6995050 11.40140373 0.0007546 0.033519117 -1.118345985 SLC25A4 59462 8 54 3 11.6995050 11.40140373 0.0007546 0.033519117 -1.118345985 PGRMC1 0 8 54 11.5026517 11.2266184 0.0008006 0.033727227 -1.110304444 ZNF75D 0 72 11.5026517 11.2266184 0.0008006 0.033727227 -1.110304444 CT55 154943 72 11.5026517 11.2266184 0.0008006 0.033727227 -1.110304444 ZNF449 0 72 11.4990185 11.26923614 9.15961E- 0.027503923 -1.126608228 MSN 225530 1 05 11.4990185 11.26923614 9.15961E- 0.027503923 -1.126608228 HEPH 141474 1 05 11.4990185 11.26923614 9.15961E- 0.027503923 -1.126608228 VSIG4 663 1 05 11.5420696 11.38756674 0.0001495 0.027503923 -1.103872583 HEPH 107985 8 46 11.5420696 11.38756674 0.0001495 0.027503923 -1.103872583 VSIG4 0 8 46 11.5420696 11.38756674 0.0001495 0.027503923 -1.103872583 MSN 225530 8 46 12.0059578 11.7354512 8.83429E- 0.027503923 -1.143177367 TBX22 183619 1 05 12.0059578 11.7354512 8.83429E- 0.027503923 -1.143177367 FAM46D 95211 1 05 12.0059578 11.7354512 8.83429E- 0.027503923 -1.143177367 TBX22 184277 1 05 11.3294547 11.09529498 0.0001103 0.027503923 -1.129839288 TBX22 184277 3 13 11.3294547 11.09529498 0.0001103 0.027503923 -1.129839288 FAM46D 38964 3 13 11.3294547 11.09529498 0.0001103 0.027503923 -1.129839288 TBX22 183619 3 13 12.0849755 11.75121367 0.0002899 0.029009077 -1.149873028 TBX22 183619 3 62 12.0849755 11.75121367 0.0002899 0.029009077 -1.149873028 TBX22 184277 3 62 12.0849755 11.75121367 0.0002899 0.029009077 -1.149873028 FAM46D 19251 3 62 11.5561960 11.33379076 0.0002923 0.029009077 -1.113452212 TBX22 184277 4 57 11.5561960 11.33379076 0.0002923 0.029009077 -1.113452212 FAM46D 0 4 57 11.5561960 11.33379076 0.0002923 0.029009077 -1.113452212 TBX22 183619 4 57

[0002] Table 7(a) probe T1 T2 1 Hg38_1_110068665_110070092_110115866_110124007_RR 8.784988722 8.68349524 2 Hg38_1_110068665_110070092_110115866_110124007_RR 8.784988722 8.68349524 3 Hg38_1_110068665_110070092_110115866_110124007_RR 8.784988722 8.68349524 4 Hg38_1_110068665_110070092_110196330_110204650_RR 9.179661786 9.096172608 5 Hg38_1_110068665_110070092_110196330_110204650_RR 9.179661786 9.096172608 6 Hg38_1_110068665_110070092_110196330_110204650_RR 9.179661786 9.096172608 7 Hg38_1_110068665_110070092_110196330_110204650_RR 9.179661786 9.096172608 8 Hg38_1_112629022_112635827_112711055_112715111_RF 8.740762496 8.622852108 9 Hg38_1_112629022_112635827_112711055_112715111_RF 8.740762496 8.622852108 10 Hg38_1_112629022_112635827_112711055_112715111_RF 8.740762496 8.622852108 11 Hg38_1_112629022_112635827_112711055_112715111_RF 8.740762496 8.622852108 12 Hg38_1_112629022_112635827_112711055_112715111_RF 8.740762496 8.622852108 13 Hg38_1_161592992_161600164_161645837_161653201_RR 9.929510627 9.808207198 14 Hg38_1_161592992_161600164_161645837_161653201_RR 9.929510627 9.808207198 15 Hg38_1_161592992_161600164_161645837_161653201_RR 9.929510627 9.808207198 16 Hg38_1_206636214_206640771_206772311_206775273_RR 9.148847138 9.028307853 17 Hg38_1_206636214_206640771_206772311_206775273_RR 9.148847138 9.028307853 18 Hg38_1_206636214_206640771_206772311_206775273_RR 9.148847138 9.028307853 19 Hg38_1_29118324_29122247_29204712_29206552_FF 8.950139072 8.801950832 20 Hg38_1_29118324_29122247_29204712_29206552_FF 8.950139072 8.801950832 21 Hg38_1_29118324_29122247_29204712_29206552_FF 8.950139072 8.801950832 22 Hg38_1_29118324_29122247_29204712_29206552_FF 8.950139072 8.801950832 23 Hg38_1_29118324_29122247_29232635_29236967_FR 8.927664761 8.82018649 24 Hg38_1_29118324_29122247_29232635_29236967_FR 8.927664761 8.82018649 25 Hg38_1_29118324_29122247_29232635_29236967_FR 8.927664761 8.82018649 26 Hg38_1_29118324_29122247_29232635_29236967_FR 8.927664761 8.82018649 27 Hg38_1_29118324_29122247_29232635_29236967_FR 8.927664761 8.82018649 28 Hg38_1_29118324_29122247_29246968_29253743_FF 8.805864174 8.592638994 29 Hg38_1_29118324_29122247_29246968_29253743_FF 8.805864174 8.592638994 30 Hg38_1_29118324_29122247_29246968_29253743_FF 8.805864174 8.592638994 31 Hg38_1_29118324_29122247_29246968_29253743_FF 8.805864174 8.592638994 32 Hg38_1_29118324_29122247_29246968_29253743_FF 8.805864174 8.592638994 33 Hg38_1_29118324_29122247_29255879_29258184_FR 9.035971129 8.892989051 34 Hg38_1_29118324_29122247_29255879_29258184_FR 9.035971129 8.892989051 35 Hg38_1_29118324_29122247_29255879_29258184_FR 9.035971129 8.892989051 36 Hg38_1_29118324_29122247_29255879_29258184_FR 9.035971129 8.892989051 37 Hg38_1_29118324_29122247_29255879_29258184_FR 9.035971129 8.892989051 38 Hg38_1_29118324_29122247_29294948_29295950_FR 8.873548468 8.765920156 39 Hg38_1_29118324_29122247_29294948_29295950_FR 8.873548468 8.765920156 40 Hg38_1_29118324_29122247_29294948_29295950_FR 8.873548468 8.765920156 41 Hg38_1_29118324_29122247_29294948_29295950_FR 8.873548468 8.765920156 42 Hg38_1_29118324_29122247_29294948_29295950_FR 8.873548468 8.765920156 Hg38_1_29118324_29122247_29297519_29304189_FF 8.792032624 8.657812399 Hg38_1_29118324_29122247_29297519_29304189_FF 8.792032624 8.657812399 Hg38_1_29118324_29122247_29297519_29304189_FF 8.792032624 8.657812399 Hg38_1_29118324_29122247_29297519_29304189_FF 8.792032624 8.657812399 Hg38_1_29118324_29122247_29297519_29304189_FF 8.792032624 8.657812399 Hg38_1_29118324_29122247_29307334_29308366_FR 8.83639878 8.709546477 Hg38_1_29118324_29122247_29307334_29308366_FR 8.83639878 8.709546477 Hg38_1_29118324_29122247_29307334_29308366_FR 8.83639878 8.709546477 Hg38_1_29118324_29122247_29307334_29308366_FR 8.83639878 8.709546477 Hg38_1_29118324_29122247_29307334_29308366_FR 8.83639878 8.709546477 Hg38_1_54049994_54051794_54222118_54228307_FF 9.308742004 9.058242005 Hg38_1_54049994_54051794_54222118_54228307_FF 9.308742004 9.058242005 Hg38_1_54049994_54051794_54222118_54228307_FF 9.308742004 9.058242005 Hg38_1_54049994_54051794_54222118_54228307_FF 9.308742004 9.058242005 Hg38_1_54049994_54051794_54222118_54228307_FF 9.308742004 9.058242005 Hg38_1_54049994_54051794_54222118_54228307_FF 9.308742004 9.058242005 Hg38_1_54049994_54051794_54222118_54228307_FF 9.308742004 9.058242005 Hg38_1_54056546_54062574_54222118_54228307_FF 9.646383763 9.492308268 Hg38_1_54056546_54062574_54222118_54228307_FF 9.646383763 9.492308268 Hg38_1_54056546_54062574_54222118_54228307_FF 9.646383763 9.492308268 Hg38_1_54056546_54062574_54222118_54228307_FF 9.646383763 9.492308268 Hg38_1_54056546_54062574_54222118_54228307_FF 9.646383763 9.492308268 Hg38_1_54056546_54062574_54222118_54228307_FF 9.646383763 9.492308268 Hg38_1_54072616_54079042_54222118_54228307_FF 9.878802271 9.686054836 Hg38_1_54072616_54079042_54222118_54228307_FF 9.878802271 9.686054836 Hg38_1_54072616_54079042_54222118_54228307_FF 9.878802271 9.686054836 Hg38_1_54072616_54079042_54222118_54228307_FF 9.878802271 9.686054836 Hg38_1_54072616_54079042_54222118_54228307_FF 9.878802271 9.686054836 Hg38_1_54072616_54079042_54222118_54228307_FF 9.878802271 9.686054836 Hg38_1_75950835_75957608_76000194_76003911_FF 8.726637665 8.643243521 Hg38_1_75950835_75957608_76000194_76003911_FF 8.726637665 8.643243521 Hg38_1_75950835_75957608_76000194_76003911_FF 8.726637665 8.643243521 Hg38_1_9604154_9606795_9879392_9882917_FR 9.423271864 9.20622261 Hg38_1_9604154_9606795_9879392_9882917_FR 9.423271864 9.20622261 Hg38_1_9604154_9606795_9879392_9882917_FR 9.423271864 9.20622261 Hg38_1_9604154_9606795_9879392_9882917_FR 9.423271864 9.20622261 Hg38_1_9604154_9606795_9879392_9882917_FR 9.423271864 9.20622261 Hg38_10_1020513_1022055_1177891_1179415_RF 8.818248323 8.609317951 Hg38_10_1020513_1022055_1177891_1179415_RF 8.818248323 8.609317951 Hg38_10_1020513_1022055_1177891_1179415_RF 8.818248323 8.609317951 Hg38_10_1020513_1022055_1177891_1179415_RF 8.818248323 8.609317951 Hg38_10_110941768_110946955_111076640_111078377_R 9.055373272 8.949471994 F Hg38_10_110941768_110946955_111076640_111078377_R 9.055373272 8.949471994 F Hg38_10_110941768_110946955_111076640_111078377_R 9.055373272 8.949471994 F Hg38_10_110984519_110990497_111076640_111078377_R 8.98076915 8.945387348 F Hg38_10_110984519_110990497_111076640_111078377_R 8.98076915 8.945387348 F Hg38_10_110984519_110990497_111076640_111078377_R 8.98076915 8.945387348 F Hg38_10_111029413_111033790_111076640_111078377_R 9.081206231 8.907850886 F Hg38_10_111029413_111033790_111076640_111078377_R 9.081206231 8.907850886 F Hg38_10_111029413_111033790_111076640_111078377_R 9.081206231 8.907850886 F Hg38_10_111076640_111078377_111095250_111098479_F 8.958777679 8.831611704 R Hg38_10_111076640_111078377_111095250_111098479_F 8.958777679 8.831611704 R Hg38_10_111076640_111078377_111095250_111098479_F 8.958777679 8.831611704 R Hg38_10_111076640_111078377_111130979_111137680_F 9.037448133 8.910024805 R Hg38_10_111076640_111078377_111130979_111137680_F 9.037448133 8.910024805 R Hg38_10_111076640_111078377_111130979_111137680_F 9.037448133 8.910024805 R Hg38_10_111076640_111078377_111150957_111155548_F 9.460296182 9.321260581 R Hg38_10_111076640_111078377_111150957_111155548_F 9.460296182 9.321260581 R Hg38_10_111076640_111078377_111150957_111155548_F 9.460296182 9.321260581 R Hg38_10_111076640_111078377_111174638_111177868_F 8.758177065 8.671167801 R Hg38_10_111076640_111078377_111174638_111177868_F 8.758177065 8.671167801 R Hg38_10_111076640_111078377_111174638_111177868_F 8.758177065 8.671167801 R Hg38_10_111076640_111078377_111182462_111185999_F 8.980156488 8.849227188 R Hg38_10_111076640_111078377_111182462_111185999_F 8.980156488 8.849227188 R Hg38_10_111076640_111078377_111182462_111185999_F 8.980156488 8.849227188 R Hg38_10_111076640_111078377_111238175_111245848_F 9.509461064 9.363523719 F Hg38_10_111076640_111078377_111238175_111245848_F 9.509461064 9.363523719 F Hg38_10_111076640_111078377_111238175_111245848_F 9.509461064 9.363523719 F Hg38_10_111076640_111078377_111238175_111245848_F 9.202178287 9.091653813 R Hg38_10_111076640_111078377_111238175_111245848_F 9.202178287 9.091653813 R Hg38_10_111076640_111078377_111238175_111245848_F 9.202178287 9.091653813 R Hg38_10_111076640_111078377_111281249_111284934_F 8.813108668 8.694122706 F Hg38_10_111076640_111078377_111281249_111284934_F 8.813108668 8.694122706 F Hg38_10_111076640_111078377_111281249_111284934_F 8.813108668 8.694122706 F Hg38_10_97318784_97323308_97446023_97447374_RR 9.402182039 9.283854889 Hg38_10_97318784_97323308_97446023_97447374_RR 9.402182039 9.283854889 Hg38_10_97318784_97323308_97446023_97447374_RR 9.402182039 9.283854889 Hg38_10_97318784_97323308_97446023_97447374_RR 9.402182039 9.283854889 Hg38_10_97318784_97323308_97446023_97447374_RR 9.402182039 9.283854889 Hg38_10_97318784_97323308_97446023_97447374_RR 9.402182039 9.283854889 Hg38_11_1999367_2001655_2063102_2072679_FR 9.102706486 8.899485289 Hg38_11_1999367_2001655_2063102_2072679_FR 9.102706486 8.899485289 Hg38_11_1999367_2001655_2063102_2072679_FR 9.102706486 8.899485289 Hg38_11_1999367_2001655_2170498_2173159_FF 9.438529428 9.361632036 Hg38_11_1999367_2001655_2170498_2173159_FF 9.438529428 9.361632036 Hg38_11_1999367_2001655_2170498_2173159_FF 9.438529428 9.361632036 Hg38_11_1999367_2001655_2170498_2173159_FF 9.438529428 9.361632036 Hg38_11_1999367_2001655_2215466_2224081_FF 8.801559528 8.719043569 Hg38_11_1999367_2001655_2215466_2224081_FF 8.801559528 8.719043569 Hg38_11_1999367_2001655_2215466_2224081_FF 8.801559528 8.719043569 Hg38_11_1999367_2001655_2215466_2224081_FF 8.801559528 8.719043569 Hg38_11_56331570_56333761_56392775_56401943_RR 9.069087466 8.915361617 Hg38_11_56331570_56333761_56392775_56401943_RR 9.069087466 8.915361617 Hg38_11_56331570_56333761_56392775_56401943_RR 9.069087466 8.915361617 Hg38_12_122123958_122128557_122294560_122297581_R 8.792060429 8.67785132 F Hg38_12_122123958_122128557_122294560_122297581_R 8.792060429 8.67785132 F Hg38_12_122123958_122128557_122294560_122297581_R 8.792060429 8.67785132 F Hg38_12_122123958_122128557_122294560_122297581_R 8.792060429 8.67785132 F Hg38_12_122123958_122128557_122294560_122297581_R 8.792060429 8.67785132 F Hg38_12_122123958_122128557_122294560_122297581_R 8.792060429 8.67785132 F Hg38_12_122123958_122128557_122294560_122297581_R 8.792060429 8.67785132 F Hg38_12_122123958_122128557_122294560_122297581_R 8.792060429 8.67785132 F Hg38_12_48329440_48346125_48504233_48508248_RF 9.301224419 9.169370877 Hg38_12_48329440_48346125_48504233_48508248_RF 9.301224419 9.169370877 Hg38_12_48329440_48346125_48504233_48508248_RF 9.301224419 9.169370877 Hg38_12_48329440_48346125_48504233_48508248_RF 9.301224419 9.169370877 Hg38_12_48329440_48346125_48504233_48508248_RF 9.301224419 9.169370877 Hg38_12_53859818_53865250_54034333_54035576_FF 9.182154864 8.978836153 Hg38_12_53859818_53865250_54034333_54035576_FF 9.182154864 8.978836153 Hg38_12_53859818_53865250_54034333_54035576_FF 9.182154864 8.978836153 Hg38_12_53859818_53865250_54034333_54035576_FF 9.182154864 8.978836153 Hg38_12_53859818_53865250_54034333_54035576_FF 9.182154864 8.978836153 Hg38_12_53859818_53865250_54034333_54035576_FF 9.182154864 8.978836153 Hg38_12_53859818_53865250_54034333_54035576_FF 9.182154864 8.978836153 Hg38_12_53859818_53865250_54034333_54035576_FF 9.182154864 8.978836153 Hg38_12_53859818_53865250_54034333_54035576_FF 9.182154864 8.978836153 Hg38_12_53859818_53865250_54034333_54035576_FF 9.182154864 8.978836153 Hg38_12_53906777_53911847_54034333_54035576_RF 9.550680005 9.392787514 Hg38_12_53906777_53911847_54034333_54035576_RF 9.550680005 9.392787514 Hg38_12_53906777_53911847_54034333_54035576_RF 9.550680005 9.392787514 Hg38_12_53906777_53911847_54034333_54035576_RF 9.550680005 9.392787514 Hg38_12_53906777_53911847_54034333_54035576_RF 9.550680005 9.392787514 Hg38_12_53906777_53911847_54034333_54035576_RF 9.550680005 9.392787514 Hg38_12_53906777_53911847_54034333_54035576_RF 9.550680005 9.392787514 Hg38_12_53906777_53911847_54034333_54035576_RF 9.550680005 9.392787514 Hg38_12_53906777_53911847_54034333_54035576_RF 9.550680005 9.392787514 Hg38_12_53906777_53911847_54034333_54035576_RF 9.550680005 9.392787514 Hg38_12_55392834_55395473_55435622_55452705_RF 9.659963328 9.523214664 Hg38_12_55392834_55395473_55435622_55452705_RF 9.659963328 9.523214664 Hg38_12_55392834_55395473_55435622_55452705_RF 9.659963328 9.523214664 Hg38_12_57754646_57757646_58008255_58018341_RR 8.795929791 8.637208517 Hg38_12_57754646_57757646_58008255_58018341_RR 8.795929791 8.637208517 Hg38_12_57754646_57757646_58008255_58018341_RR 8.795929791 8.637208517 Hg38_12_57754646_57757646_58008255_58018341_RR 8.795929791 8.637208517 Hg38_12_57754646_57757646_58008255_58018341_RR 8.795929791 8.637208517 Hg38_12_57754646_57757646_58008255_58018341_RR 8.795929791 8.637208517 Hg38_12_57754646_57757646_58008255_58018341_RR 8.795929791 8.637208517 Hg38_12_57754646_57757646_58008255_58018341_RR 8.795929791 8.637208517 Hg38_12_57754646_57757646_58008255_58018341_RR 8.795929791 8.637208517 Hg38_12_57754646_57757646_58008255_58018341_RR 8.795929791 8.637208517 Hg38_13_99809682_99818519_99978729_99980288_RF 9.622431792 9.481651279 Hg38_13_99809682_99818519_99978729_99980288_RF 9.622431792 9.481651279 Hg38_13_99809682_99818519_99978729_99980288_RF 9.622431792 9.481651279 Hg38_14_106059619_106067374_106316941_106324350_R 8.869326995 8.748354224 F Hg38_14_106059619_106067374_106316941_106324350_R 8.869326995 8.748354224 F Hg38_14_106059619_106067374_106316941_106324350_R 8.869326995 8.748354224 F Hg38_14_106101485_106113325_106324350_106329828_R 9.604569646 9.362773196 R Hg38_14_106101485_106113325_106324350_106329828_R 9.604569646 9.362773196 R Hg38_14_106101485_106113325_106324350_106329828_R 9.604569646 9.362773196 R Hg38_14_106229829_106239383_106316941_106324350_R 8.785641105 8.517871967 F Hg38_14_106229829_106239383_106316941_106324350_R 8.785641105 8.517871967 F Hg38_14_106229829_106239383_106316941_106324350_R 8.785641105 8.517871967 F Hg38_14_106265349_106270131_106324350_106329828_F 9.478529263 9.388241971 F Hg38_14_106265349_106270131_106324350_106329828_F 9.478529263 9.388241971 F Hg38_14_106265349_106270131_106324350_106329828_F 9.478529263 9.388241971 F Hg38_14_106265349_106270131_106442692_106446995_F 9.573038525 9.372579114 F Hg38_14_106265349_106270131_106442692_106446995_F 9.573038525 9.372579114 F Hg38_14_106265349_106270131_106442692_106446995_F 9.573038525 9.372579114 F Hg38_14_106316941_106324350_106349379_106355290_F 9.126510744 8.891046024 F Hg38_14_106316941_106324350_106349379_106355290_F 9.126510744 8.891046024 F Hg38_14_106316941_106324350_106349379_106355290_F 9.126510744 8.891046024 F Hg38_14_106316941_106324350_106349379_106355290_R 9.52995754 9.431578113 R Hg38_14_106316941_106324350_106349379_106355290_R 9.52995754 9.431578113 R Hg38_14_106316941_106324350_106349379_106355290_R 9.52995754 9.431578113 R Hg38_14_106316941_106324350_106461342_106467091_F 8.854945312 8.635924617 R Hg38_14_106316941_106324350_106461342_106467091_F 8.854945312 8.635924617 R Hg38_14_106316941_106324350_106461342_106467091_F 8.854945312 8.635924617 R Hg38_14_106461342_106467091_106620898_106627345_R 9.715038198 9.535970397 F Hg38_14_106461342_106467091_106620898_106627345_R 9.715038198 9.535970397 F Hg38_14_106461342_106467091_106620898_106627345_R 9.715038198 9.535970397 F Hg38_14_106515010_106526411_106620898_106627345_R 9.724127727 9.556458198 F Hg38_14_106515010_106526411_106620898_106627345_R 9.724127727 9.556458198 F Hg38_14_106515010_106526411_106620898_106627345_R 9.724127727 9.556458198 F Hg38_14_106548482_106555656_106620898_106627345_R 9.752946265 9.546209809 F Hg38_14_106548482_106555656_106620898_106627345_R 9.752946265 9.546209809 F Hg38_14_106548482_106555656_106620898_106627345_R 9.752946265 9.546209809 F Hg38_14_106574156_106577342_106620898_106627345_R 9.743747313 9.558957643 F Hg38_14_106574156_106577342_106620898_106627345_R 9.743747313 9.558957643 F Hg38_14_106574156_106577342_106620898_106627345_R 9.743747313 9.558957643 F Hg38_14_106598287_106603277_106620898_106627345_R 9.432937597 9.237276185 F Hg38_14_106598287_106603277_106620898_106627345_R 9.432937597 9.237276185 F Hg38_14_106598287_106603277_106620898_106627345_R 9.432937597 9.237276185 F Hg38_14_106620898_106627345_106647836_106650895_F 9.878568677 9.690421582 R Hg38_14_106620898_106627345_106647836_106650895_F 9.878568677 9.690421582 R Hg38_14_106620898_106627345_106647836_106650895_F 9.878568677 9.690421582 R Hg38_14_106620898_106627345_106676506_106682464_F 9.610992902 9.531525988 F Hg38_14_106620898_106627345_106676506_106682464_F 9.610992902 9.531525988 F Hg38_14_106620898_106627345_106676506_106682464_F 9.610992902 9.531525988 F Hg38_14_106620898_106627345_106676506_106682464_F 9.758935341 9.607683775 R Hg38_14_106620898_106627345_106676506_106682464_F 9.758935341 9.607683775 R Hg38_14_106620898_106627345_106676506_106682464_F 9.758935341 9.607683775 R Hg38_14_106620898_106627345_106693397_106698909_F 9.834597518 9.650262797 F Hg38_14_106620898_106627345_106693397_106698909_F 9.834597518 9.650262797 F Hg38_14_106620898_106627345_106693397_106698909_F 9.834597518 9.650262797 F Hg38_14_106620898_106627345_106693397_106698909_F 9.621809625 9.530214017 R Hg38_14_106620898_106627345_106693397_106698909_F 9.621809625 9.530214017 R Hg38_14_106620898_106627345_106693397_106698909_F 9.621809625 9.530214017 R Hg38_14_106620898_106627345_106713020_106717244_F 9.775319662 9.665775576 R Hg38_14_106620898_106627345_106713020_106717244_F 9.775319662 9.665775576 R Hg38_14_106620898_106627345_106713020_106717244_F 9.775319662 9.665775576 R Hg38_14_106620898_106627345_106757523_106764964_F 9.715452721 9.557399456 F Hg38_14_106620898_106627345_106757523_106764964_F 9.715452721 9.557399456 F Hg38_14_106620898_106627345_106757523_106764964_F 9.715452721 9.557399456 F Hg38_14_106620898_106627345_106764964_106771299_F 9.715398002 9.593904513 F Hg38_14_106620898_106627345_106764964_106771299_F 9.715398002 9.593904513 F Hg38_14_106620898_106627345_106764964_106771299_F 9.715398002 9.593904513 F Hg38_14_106620898_106627345_106764964_106771299_F 9.756617038 9.635755256 R Hg38_14_106620898_106627345_106764964_106771299_F 9.756617038 9.635755256 R Hg38_14_106620898_106627345_106764964_106771299_F 9.756617038 9.635755256 R Hg38_14_19359963_19366066_19395038_19402239_RR 9.878743754 9.617134614 Hg38_14_19359963_19366066_19395038_19402239_RR 9.878743754 9.617134614 Hg38_14_19359963_19366066_19395038_19402239_RR 9.878743754 9.617134614 Hg38_14_19359963_19366066_19422620_19426924_RR 9.527788969 9.356674152 Hg38_14_19359963_19366066_19422620_19426924_RR 9.527788969 9.356674152 Hg38_14_19359963_19366066_19422620_19426924_RR 9.527788969 9.356674152 Hg38_14_19686062_19689366_19700333_19706197_FR 9.459439412 9.295469588 Hg38_14_19686062_19689366_19700333_19706197_FR 9.459439412 9.295469588 Hg38_14_19686062_19689366_19700333_19706197_FR 9.459439412 9.295469588 Hg38_14_19686062_19689366_19731294_19742059_FF 9.355343521 9.170586018 Hg38_14_19686062_19689366_19731294_19742059_FF 9.355343521 9.170586018 Hg38_14_19686062_19689366_19731294_19742059_FF 9.355343521 9.170586018 Hg38_14_19686062_19689366_19746815_19753340_FF 9.712236236 9.485619935 Hg38_14_19686062_19689366_19746815_19753340_FF 9.712236236 9.485619935 Hg38_14_19686062_19689366_19746815_19753340_FF 9.712236236 9.485619935 Hg38_14_19686062_19689366_19746815_19753340_FR 9.462462871 9.245572001 Hg38_14_19686062_19689366_19746815_19753340_FR 9.462462871 9.245572001 Hg38_14_19686062_19689366_19746815_19753340_FR 9.462462871 9.245572001 Hg38_14_19686062_19689366_19929983_19935285_FF 9.425706596 9.205984425 Hg38_14_19686062_19689366_19929983_19935285_FF 9.425706596 9.205984425 Hg38_14_19686062_19689366_19929983_19935285_FF 9.425706596 9.205984425 Hg38_14_19686062_19689366_19929983_19935285_FF 9.425706596 9.205984425 Hg38_14_19686062_19689366_19929983_19935285_FF 9.425706596 9.205984425 Hg38_14_19686062_19689366_19929983_19935285_FF 9.425706596 9.205984425 Hg38_14_19686062_19689366_19929983_19935285_FR 9.519966661 9.214027805 Hg38_14_19686062_19689366_19929983_19935285_FR 9.519966661 9.214027805 Hg38_14_19686062_19689366_19929983_19935285_FR 9.519966661 9.214027805 Hg38_14_19686062_19689366_19929983_19935285_FR 9.519966661 9.214027805 Hg38_14_19686062_19689366_19929983_19935285_FR 9.519966661 9.214027805 Hg38_14_19686062_19689366_19929983_19935285_FR 9.519966661 9.214027805 Hg38_14_19686062_19689366_19935686_19947164_FR 9.618174638 9.376108047 Hg38_14_19686062_19689366_19935686_19947164_FR 9.618174638 9.376108047 Hg38_14_19686062_19689366_19935686_19947164_FR 9.618174638 9.376108047 Hg38_14_19686062_19689366_19935686_19947164_FR 9.618174638 9.376108047 Hg38_14_19686062_19689366_19935686_19947164_FR 9.618174638 9.376108047 Hg38_14_19686062_19689366_19935686_19947164_FR 9.618174638 9.376108047 Hg38_14_19686062_19689366_19935686_19947164_FR 9.618174638 9.376108047 Hg38_14_37438474_37448812_37588373_37591433_FR 9.716358245 9.562244967 Hg38_14_37438474_37448812_37588373_37591433_FR 9.716358245 9.562244967 Hg38_14_37438474_37448812_37588373_37591433_FR 9.716358245 9.562244967 Hg38_14_37438474_37448812_37588373_37591433_RR 9.799826175 9.691970715 Hg38_14_37438474_37448812_37588373_37591433_RR 9.799826175 9.691970715 Hg38_14_37438474_37448812_37588373_37591433_RR 9.799826175 9.691970715 Hg38_14_37588373_37591433_37683263_37696743_RF 9.870339191 9.722827707 Hg38_14_37588373_37591433_37683263_37696743_RF 9.870339191 9.722827707 Hg38_14_37588373_37591433_37683263_37696743_RF 9.870339191 9.722827707 Hg38_15_20433490_20437116_20567686_20576350_RR 9.863551955 9.700586632 Hg38_15_20433490_20437116_20567686_20576350_RR 9.863551955 9.700586632 Hg38_15_20433490_20437116_20567686_20576350_RR 9.863551955 9.700586632 Hg38_15_41813069_41821413_41966600_41972320_RF 9.287812286 9.18862944 Hg38_15_41813069_41821413_41966600_41972320_RF 9.287812286 9.18862944 Hg38_15_41813069_41821413_41966600_41972320_RF 9.287812286 9.18862944 Hg38_15_41813069_41821413_41966600_41972320_RF 9.287812286 9.18862944 Hg38_15_41813069_41821413_41966600_41972320_RF 9.287812286 9.18862944 Hg38_15_41813069_41821413_41966600_41972320_RF 9.287812286 9.18862944 Hg38_15_74202192_74207631_74262965_74270596_FR 8.762115548 8.621116092 Hg38_15_74202192_74207631_74262965_74270596_FR 8.762115548 8.621116092 Hg38_15_74202192_74207631_74262965_74270596_FR 8.762115548 8.621116092 Hg38_15_82045591_82047643_82191531_82196829_RR 9.779998433 9.582537227 Hg38_15_82045591_82047643_82191531_82196829_RR 9.779998433 9.582537227 Hg38_15_82045591_82047643_82191531_82196829_RR 9.779998433 9.582537227 Hg38_15_82275954_82282996_82342450_82344596_FF 9.837938768 9.720714195 Hg38_15_82275954_82282996_82342450_82344596_FF 9.837938768 9.720714195 Hg38_15_82275954_82282996_82342450_82344596_FF 9.837938768 9.720714195 Hg38_16_1213859_1215028_1476312_1478329_FF 9.134975731 9.035159088 Hg38_16_1213859_1215028_1476312_1478329_FF 9.134975731 9.035159088 Hg38_16_1213859_1215028_1476312_1478329_FF 9.134975731 9.035159088 Hg38_16_1213859_1215028_1476312_1478329_FF 9.134975731 9.035159088 Hg38_16_1213859_1215028_1476312_1478329_FF 9.134975731 9.035159088 Hg38_16_1213859_1215028_1476312_1478329_FF 9.134975731 9.035159088 Hg38_16_1213859_1215028_1476312_1478329_FF 9.134975731 9.035159088 Hg38_16_1213859_1215028_1476312_1478329_FF 9.134975731 9.035159088 Hg38_16_1213859_1215028_1476312_1478329_FF 9.134975731 9.035159088 Hg38_16_1213859_1215028_1476312_1478329_FF 9.134975731 9.035159088 Hg38_16_1213859_1215028_1476312_1478329_FF 9.134975731 9.035159088 Hg38_16_1213859_1215028_1476312_1478329_FF 9.134975731 9.035159088 Hg38_16_1213859_1215028_1476312_1478329_FF 9.134975731 9.035159088 Hg38_16_29349474_29351919_29466069_29474702_FR 9.787165044 9.65306083 Hg38_16_29349474_29351919_29466069_29474702_FR 9.787165044 9.65306083 Hg38_16_29349474_29351919_29466069_29474702_FR 9.787165044 9.65306083 Hg38_16_29349474_29351919_29466069_29474702_FR 9.787165044 9.65306083 Hg38_16_29349474_29351919_29466069_29474702_FR 9.787165044 9.65306083 Hg38_16_29349474_29351919_29466069_29474702_FR 9.787165044 9.65306083 Hg38_16_30775580_30779073_30954544_30957318_RR 9.361949987 9.280860561 Hg38_16_30775580_30779073_30954544_30957318_RR 9.361949987 9.280860561 Hg38_16_30775580_30779073_30954544_30957318_RR 9.361949987 9.280860561 Hg38_16_30775580_30779073_30954544_30957318_RR 9.361949987 9.280860561 Hg38_16_30775580_30779073_30954544_30957318_RR 9.361949987 9.280860561 Hg38_16_30775580_30779073_30954544_30957318_RR 9.361949987 9.280860561 Hg38_16_30775580_30779073_30954544_30957318_RR 9.361949987 9.280860561 Hg38_16_32310442_32316122_32456290_32461705_RR 9.781706539 9.752802298 Hg38_16_32310442_32316122_32456290_32461705_RR 9.781706539 9.752802298 Hg38_16_32310442_32316122_32456290_32461705_RR 9.781706539 9.752802298 Hg38_16_33554881_33560571_33617246_33623072_RF 9.595506121 9.510590622 Hg38_16_33554881_33560571_33617246_33623072_RF 9.595506121 9.510590622 Hg38_16_33554881_33560571_33617246_33623072_RF 9.595506121 9.510590622 Hg38_16_33554881_33560571_33707569_33715659_RF 9.654864033 9.542398204 Hg38_16_33554881_33560571_33707569_33715659_RF 9.654864033 9.542398204 Hg38_16_33554881_33560571_33707569_33715659_RF 9.654864033 9.542398204 Hg38_16_33554881_33560571_33735378_33743698_RF 9.63621763 9.562883815 Hg38_16_33554881_33560571_33735378_33743698_RF 9.63621763 9.562883815 Hg38_16_33554881_33560571_33735378_33743698_RF 9.63621763 9.562883815 Hg38_16_33554881_33560571_33735378_33743698_RR 9.962582318 9.821001876 Hg38_16_33554881_33560571_33735378_33743698_RR 9.962582318 9.821001876 Hg38_16_33554881_33560571_33735378_33743698_RR 9.962582318 9.821001876 Hg38_16_75473984_75478931_75501827_75504626_FF 9.487141508 9.347961969 Hg38_16_75473984_75478931_75501827_75504626_FF 9.487141508 9.347961969 Hg38_16_75473984_75478931_75501827_75504626_FF 9.487141508 9.347961969 Hg38_17_3844648_3846586_4024828_4029672_FR 8.949950165 8.910763774 Hg38_17_3844648_3846586_4024828_4029672_FR 8.949950165 8.910763774 Hg38_17_3844648_3846586_4024828_4029672_FR 8.949950165 8.910763774 Hg38_17_3844648_3846586_4024828_4029672_FR 8.949950165 8.910763774 Hg38_17_3844648_3846586_4024828_4029672_FR 8.949950165 8.910763774 Hg38_17_40133064_40137400_40336758_40342414_RF 9.221106173 9.113177802 Hg38_17_40133064_40137400_40336758_40342414_RF 9.221106173 9.113177802 Hg38_17_40133064_40137400_40336758_40342414_RF 9.221106173 9.113177802 Hg38_17_40133064_40137400_40336758_40342414_RF 9.221106173 9.113177802 Hg38_17_40133064_40137400_40336758_40342414_RF 9.221106173 9.113177802 Hg38_17_40133064_40137400_40336758_40342414_RF 9.221106173 9.113177802 Hg38_17_48548256_48552067_48610757_48613402_FR 9.005754224 8.850804492 Hg38_17_48548256_48552067_48610757_48613402_FR 9.005754224 8.850804492 Hg38_17_48548256_48552067_48610757_48613402_FR 9.005754224 8.850804492 Hg38_17_48548256_48552067_48610757_48613402_FR 9.005754224 8.850804492 Hg38_17_48548256_48552067_48610757_48613402_FR 9.005754224 8.850804492 Hg38_17_48548256_48552067_48610757_48613402_FR 9.005754224 8.850804492 Hg38_17_7079217_7081666_7239407_7241938_RF 9.506168083 9.302464467 Hg38_17_7079217_7081666_7239407_7241938_RF 9.506168083 9.302464467 Hg38_17_7079217_7081666_7239407_7241938_RF 9.506168083 9.302464467 Hg38_17_7079217_7081666_7239407_7241938_RF 9.506168083 9.302464467 Hg38_17_7079217_7081666_7239407_7241938_RF 9.506168083 9.302464467 Hg38_17_7079217_7081666_7239407_7241938_RF 9.506168083 9.302464467 Hg38_17_7079217_7081666_7239407_7241938_RF 9.506168083 9.302464467 Hg38_17_7079217_7081666_7239407_7241938_RF 9.506168083 9.302464467 Hg38_17_7079217_7081666_7239407_7241938_RF 9.506168083 9.302464467 Hg38_17_7079217_7081666_7314711_7316533_RF 9.186908819 9.012080017 Hg38_17_7079217_7081666_7314711_7316533_RF 9.186908819 9.012080017 Hg38_17_7079217_7081666_7314711_7316533_RF 9.186908819 9.012080017 Hg38_17_7079217_7081666_7314711_7316533_RF 9.186908819 9.012080017 Hg38_17_7079217_7081666_7314711_7316533_RF 9.186908819 9.012080017 Hg38_17_7079217_7081666_7314711_7316533_RF 9.186908819 9.012080017 Hg38_17_7079217_7081666_7314711_7316533_RF 9.186908819 9.012080017 Hg38_17_7079217_7081666_7314711_7316533_RF 9...

Claims

CLAIMS 1. A method of determining ageing in an individual, comprising detecting the presence or absence of one or more chromosome interactions shown in any of Tables 1 to 15, to thereby determine said ageing in the individual, wherein optionally a multidimensional measure of ageing is determined by detecting the presence or absence of one or more chromosome interactions from more than one of tables 1 to 15.

2. A method according to claim 1 wherein the presence and / or absence of chromosome interactions in any of the following combinations of chromosome interactions is determined: - all of the first 10 chromosome interactions listed in at least 5 of the tables 1 to 15, or - at least 5 of the first 10 chromosome interactions listed in at least 5 of the tables 1 to 15, or - all of the first 10 chromosome interactions listed in all of the tables 1 to 15.

3. A method according to claim 1 or 2 wherein the presence and / or absence of chromosome interactions in any of the following combinations of chromosome interactions is determined: - any of the chromosome interactions listed in table 28 or 30, or - at least 5 of the chromosome interactions listed in either table 28 or 30, or - at least 5 of the chromosome interactions listed in table 28 and at least 5 of the chromosome interactions listed in table 30.

4. A method according to any one of the preceding claims wherein the chromosome interactions are typed: - in a sample from an individual, and / or - by detecting the presence or absence of a DNA loop at the site of the chromosome interactions, and / or - detecting the presence or absence of distal regions of a chromosome being brought together in a chromosome conformation, and / or - by detecting the presence of a ligated DNA which is generated during said typing and whose sequence comprises two regions each corresponding to the regions of the chromosome which come together in the chromosome interaction, and / or - by a process which detects the proximity of the chromosome regions which have come together in the chromosome interaction.

5. A method according to any one of the preceding claims wherein said detecting of the presence or absence of the chromosome interactions is by a process comprising: (i) in vitro crosslinking of epigenetic chromosomal interactions of the individual; (ii) subjecting said cross-linked DNA to cleaving; (iii) ligating said cross-linked cleaved DNA ends to form ligated DNA; and (iv) identifying the presence or absence of said ligated DNA; to thereby determine the presence or absence of the chromosome interaction.

6. A method according to claim 4 or claim 5 wherein said ligated DNA is detected by PCR or by use of a probe.

7. A method according to claim 6 wherein detection of the ligated DNA is by use of: (i) a probe, wherein said probe has at least 70% identity to any of the probes shown in table 16, and / or (ii) PCR, wherein the PCR uses a primer pair capable of amplifying the ligated DNA, wherein one or both primers comprises a sequence which is (a) a portion of at least 10 nucleic acid bases of one of the probes shown in table 16, and / or (b) is a sequence of length 10 nucleic acid bases that is at least 70% identical (a).

8. A method according to any one of the preceding claims wherein: (i) the method is carried out at an early stage of the ageing process where the individual does not have any symptoms caused by ageing, and is preferably 40 years old or younger, and / or (ii) the method is carried out to select an individual for receiving an anti-aging intervention, which is preferably for a therapeutic or cosmetic purpose, and / or (iii) the method is carried out on individual that has been preselected based on a physical characteristic, risk factor or the presence of a symptom related to ageing, and / or (iv) the method is carried out to determine prognosis for ageing, and / or (v) the method is carried out at multiple time points, and preferably on samples which were taken from the individual at at least 2 time points which are at least 30 days apart.

9. A method according to any one of the preceding claims wherein the individual:(i) is suspected of having accelerated ageing, and / or (ii) has been admitted to hospital, and / or (iii) is a human individual.

10. A method according to any one of the preceding claims, wherein detecting the presence or absence of the chromosome interactions comprises specific detection of the ligated product by quantitative PCR (qPCR) which uses primers capable of amplifying the ligated DNA and a probe which binds the ligation site during the PCR reaction, wherein said probe comprises sequence which is complementary to sequence from each of the chromosome regions that have come together in the chromosome interaction, wherein preferably said probe comprises: - an oligonucleotide which specifically binds to said ligated DNA, and / or - a fluorophore covalently attached to the 5’ end of the oligonucleotide, and / or - a quencher covalently attached to the 3’ end of the oligonucleotide, and optionally - said fluorophore is selected from HEX, Texas Red and FAM; and / or - said probe comprises a nucleic acid sequence of length 10 to 40 nucleotide bases, preferably a length of 20 to 30 nucleotide bases.

11. A method according to any one of the preceding claims which further comprises: (i) the individual carrying out an intervention to decrease or reverse their ageing, and / or (ii) the individual is provided with advice relating to decreasing or reversing their ageing, which is preferably in the form of a written report.

12. A method according to claim 11 wherein the intervention and / or advice relates to: (i) changing their diet, preferably to restrict their calorie intake, and / or (ii) changing their lifestyle, preferably to increase their exercise.

13. An anti-ageing agent for use in a method of treating accelerated ageing, said method comprising: - determining whether an individual has accelerated ageing by the method of any one of the preceding claims, and - administering to any individual identified as having accelerated ageing said agent.

14. A cosmetic method to decrease or reverse a deterioration in physical appearance comprising: - determining whether an individual has accelerated ageing by the method of any one of claims 1 to 12, and - providing to any individual identified as having accelerated ageing an anti-ageing intervention, which is preferably administration of an anti-ageing agent.

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