Near infrared- and ultrasound-based non-invasive treatment device for migraine relief

Abstract

The present invention relates to a near infrared- and ultrasound-based non-invasive treatment device for migraine relief, comprising: a body unit to be worn on the head of a user; a plurality of function-providing units installed on the body unit to provide ultrasonic waves and near-infrared rays; and a control unit for controlling the provision of ultrasonic waves and near-infrared rays by the function-providing units.

Description

A near-infrared and ultrasound-based noninvasive treatment device for migraine relief

[0001] The present invention relates to a near-infrared and ultrasound-based non-invasive treatment device, and more particularly, to a near-infrared and ultrasound-based non-invasive treatment device that provides effective migraine relief to a user through a non-invasive method.

[0002]

[0003] Migraine is a common neurobiological disorder characterized by recurrent headaches accompanied by sensory hypersensitivity, which can significantly impair quality of life. Treatment for migraine aims to stop or reduce headache pain during an attack and restore normal functioning, while preventive treatment aims to reduce the frequency and intensity of attacks.

[0004] Current treatment of acute migraine is primarily pharmacological, with the most commonly used medications including analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), and triptans.

[0005] These medications have several contraindications and can cause serious side effects. Patients with frequent or prolonged migraines who take excessive amounts of acute migraine medications can develop chronic headaches and develop side effects related to medication abuse, leading to worse outcomes. Furthermore, chronic migraine sufferers, in particular, may develop a tolerance to existing medications, making it difficult to achieve adequate pain relief.

[0006] Therefore, there is a need for a technology that can effectively and safely relieve patients' migraines by replacing the use of medications for migraine relief.

[0007]

[0008] The present invention has been devised to solve the aforementioned problem, and the non-invasive treatment device according to the present invention is intended to provide effective migraine relief while minimizing side effects to the user through a non-invasive method of reducing inflammation of human dural fibroblasts by providing near-infrared rays and ultrasound when worn on the user's head.

[0009] In addition, the near-infrared and ultrasound-based non-invasive treatment device according to the present invention selectively provides ultrasound and near-infrared to the user's forehead, the left and right temple areas of the user, or the back of the user's head, thereby providing optimal migraine relief suitable for the user's symptoms.

[0010]

[0011] In order to solve the above-described problem, a non-invasive treatment device based on near-infrared and ultrasound for migraine relief according to one embodiment of the present invention comprises: a body part worn on a user's head; a plurality of function providing units installed on the body part to provide ultrasound and near-infrared; and a control unit that controls the provision of ultrasound and near-infrared by the function providing units.

[0012] According to another embodiment of the present invention, the function providing unit may be positioned on the body to correspond to the user's forehead area, the user's left and right temple areas, and the user's back of the head area.

[0013] According to another embodiment of the present invention, the function providing unit may be configured to include an ultrasonic generation module arranged at the center of the function providing unit to provide ultrasonic waves; and a near-infrared LED arranged at the periphery of the ultrasonic generation module to provide near-infrared rays.

[0014] According to another embodiment of the present invention, the near-infrared LEDs may be arranged in a ring at equal intervals around the ultrasonic generation module.

[0015] According to another embodiment of the present invention, the control unit can selectively control each function providing unit arranged to correspond to the user's forehead area, the user's left and right temple areas, or the user's back of the head area.

[0016] According to another embodiment of the present invention, the ultrasonic generation module can generate and provide ultrasonic waves of 1 MHz, and the near-infrared LED can provide near-infrared rays of 1050 nm.

[0017] According to another embodiment of the present invention, the body part may be configured as an annular type band, headband hat, or mounting device corresponding to the circumference of the user's head.

[0018]

[0019] The non-invasive treatment device according to the present invention can provide effective migraine relief while minimizing side effects for the user through a non-invasive method of reducing inflammation of human dural fibroblasts by providing near-infrared rays and ultrasound when worn on the user's head.

[0020] In addition, the near-infrared and ultrasound-based non-invasive treatment device according to the present invention can provide optimal migraine relief suitable for the user's symptoms by selectively providing ultrasound and near-infrared to the user's forehead, the left and right temple areas of the user, or the back of the user's head.

[0021]

[0022] FIG. 1 and FIG. 2 are drawings for explaining the inflammation relief mechanism of the near-infrared and ultrasound-based non-invasive treatment device according to the present invention.

[0023] FIG. 3 and FIG. 4 are drawings illustrating a near-infrared and ultrasound-based non-invasive treatment device for migraine relief according to one embodiment of the present invention.

[0024] Figure 5 is a diagram illustrating a function providing unit of a near-infrared and ultrasound-based non-invasive treatment device for migraine relief.

[0025] FIG. 6 is a graph illustrating the anti-inflammatory effect of human dural fibroblasts according to LED wavelength and energy of a near-infrared and ultrasound-based non-invasive treatment device for migraine relief according to one embodiment of the present invention.

[0026] FIG. 7 is a graph illustrating the anti-inflammatory effect of human dural fibroblasts according to ultrasound stimulation of a near-infrared and ultrasound-based non-invasive treatment device for migraine relief according to one embodiment of the present invention.

[0027] FIG. 8 is a graph illustrating the anti-inflammatory effect of human dural fibroblasts according to LED wavelength and energy of a near-infrared and ultrasound-based non-invasive treatment device for migraine relief according to one embodiment of the present invention.

[0028] FIG. 9 is a graph for explaining whether human dural fibroblasts are cytotoxic according to LED wavelength and energy of a near-infrared and ultrasound-based non-invasive treatment device for migraine relief according to one embodiment of the present invention.

[0029] FIG. 10 is a graph illustrating whether human dural fibroblasts are cytotoxic due to ultrasound stimulation of a near-infrared and ultrasound-based non-invasive treatment device for migraine relief according to an embodiment of the present invention.

[0030]

[0031] The present invention is susceptible to various modifications and embodiments. Specific embodiments are illustrated in the drawings and described in detail in the detailed description. However, this is not intended to limit the present invention to specific embodiments, but rather to encompass all modifications, equivalents, and alternatives falling within the spirit and technical scope of the present invention.

[0032] However, when describing embodiments, if a detailed description of a related known function or configuration is judged to unnecessarily obscure the gist of the present invention, a detailed description thereof will be omitted. Furthermore, the sizes of each component in the drawings may be exaggerated for illustrative purposes and do not necessarily represent the sizes actually applied.

[0033] Additionally, throughout the specification, when a component is referred to as being "connected" or "connected" to another component, it should be understood that the component may be directly connected or connected to the other component, but may also be connected or connected via another component in between, unless otherwise specifically stated. Additionally, throughout the specification, when it is said that a part "includes" a component, this does not exclude other components, but rather includes other components, unless otherwise specifically stated.

[0034] FIG. 1 and FIG. 2 are drawings for explaining the inflammation relief mechanism of the near-infrared and ultrasound-based non-invasive treatment device according to the present invention.

[0035] Hereinafter, the inflammation relief mechanism of the near-infrared and ultrasound-based non-invasive treatment device according to the present invention will be described with reference to FIGS. 1 and 2.

[0036] The dura mater is the outermost layer of the meninges and functions to transport blood from the brain to the heart and contain cerebrospinal fluid. The dura mater is composed of the periosteum and the meningeal layers.

[0037] Fibroblasts are generally responsible for extracellular matrix synthesis in connective tissue and play a crucial role in wound healing. Dural fibroblasts (DuF) produce extracellular matrix proteins such as collagen and fibronectin.

[0038] Dural fibroblasts may contribute to headache relief by playing a role in the activation and sensitization of dural afferent nerves, and human DuF (HDuF) can also be used to study subcutaneous hematoma and headache pathophysiology.

[0039] Therefore, the near-infrared and ultrasound-based non-invasive treatment device according to the present invention aims to provide migraine relief by reducing inflammation of human dural fibroblasts.

[0040] FIG. 3 and FIG. 4 are drawings illustrating a near-infrared and ultrasound-based non-invasive treatment device for migraine relief according to one embodiment of the present invention, and FIG. 5 is a drawing illustrating a function providing unit of a near-infrared and ultrasound-based non-invasive treatment device for migraine relief.

[0041] Hereinafter, the configuration of a near-infrared and ultrasound-based non-invasive treatment device for migraine relief will be described with reference to FIGS. 3 to 5.

[0042] A near-infrared and ultrasound-based non-invasive treatment device (100) for migraine relief according to one embodiment of the present invention comprises a body part (110), a function providing part (120), and a control part (130).

[0043] The above body part (110) is a part that constitutes the body of the non-invasive treatment device (100) and is a part that is worn on the user's head.

[0044] More specifically, the body part (110) may be configured as an annular type band corresponding to the circumference of the user's head, and may be configured with a soft material so that it can be easily worn on the user's head. In addition, the body part (110) may be configured in the form of a headband, hat, or holder that can be worn on the user's head.

[0045] The above function providing unit (120) is installed in the body unit (110) and provides ultrasound and near-infrared rays to the user's head.

[0046] At this time, a plurality of the above function providing units (120) are installed on the body part (110), and more specifically, each of the above function providing units (120) can be positioned on the body part (110) to correspond to the user's forehead area, the user's left and right temple areas, and the user's back of the head area.

[0047] Additionally, each of the above function providing units (120) may be configured to include an ultrasonic generation module (121) and a near-infrared LED (122).

[0048] More specifically, the ultrasonic generation module (121) is positioned at the center of the function providing unit (120) to provide ultrasonic waves. At this time, the ultrasonic generation module (121) may be configured to generate and provide ultrasonic waves of 1 MHz.

[0049] In addition, the near-infrared LED (122) is arranged around the ultrasonic generation module (121) to provide near-infrared rays, and the near-infrared LED (122) can be arranged in a ring shape at even intervals around the ultrasonic generation module (121).

[0050] At this time, the near-infrared LED (122) can provide near-infrared light of 1050 nm.

[0051] The above control unit (130) controls the provision of ultrasonic waves and near-infrared rays by the above function providing unit (120).

[0052] More specifically, the control unit (130) can selectively control each function providing unit (120) positioned to correspond to the user's forehead area, the user's left and right temple areas, or the user's back of the head area, and at this time, the control unit (130) can control the provision of ultrasound and near-infrared rays by controlling the ultrasonic generation module (121) and the near-infrared LED (122).

[0053] For example, at the user's command, the control unit (130) can control the ultrasonic generation module (121) and the near-infrared LED (122) to operate at a selected area among the user's forehead area, the user's left and right temple areas, and the user's back of the head area.

[0054] In addition, the control unit (130) can individually control the ultrasonic generation module (121) or the near-infrared LED (122) of the part by the user's command, and the ultrasonic generation module (121) and the near-infrared LED (122) of each function providing unit (120) can be sequentially operated by the user's programming through the control unit (130).

[0055] In addition, the control unit (130) may be configured as a separate control device or as a smart terminal. In this case, if the control unit (130) is configured as a separate control device, it can be controlled by being connected to a non-invasive treatment device by wire, and if the control unit (130) is configured as a smart terminal, it can be controlled from a distance by being connected wirelessly to a non-invasive treatment device.

[0056] FIG. 6 is a graph illustrating the anti-inflammatory effect of human dural fibroblasts according to LED wavelength and energy of a near-infrared and ultrasound-based non-invasive treatment device for migraine relief according to one embodiment of the present invention.

[0057] In the experiment of Fig. 6, human dural fibroblasts were treated with LPS, and after light irradiation at each wavelength energy, sampling was performed to analyze mRNA expression.

[0058] As shown in (a) of FIG. 6, when light of 630 nm is provided for each wavelength energy, and as shown in (b) of FIG. 6, when light of 850 nm is provided for each wavelength energy, it can be seen that the non-invasive treatment device according to an embodiment of the present invention has an effect of suppressing inflammation of human dural fibroblasts when near-infrared light of 1050 nm is provided for each wavelength energy, as shown in (c) of FIG. 6.

[0059] In addition, FIG. 7 is a graph for explaining the effect of suppressing inflammation of human dural fibroblasts by ultrasound stimulation of a near-infrared and ultrasound-based non-invasive treatment device for migraine relief according to one embodiment of the present invention.

[0060] In the experiment of Fig. 7, human dural fibroblasts were treated with LPS, ultrasonic treatment was applied, and then sampled to analyze mRNA expression.

[0061] At this time, ultrasound of 1 MHz 20% duty was applied, and it was found that it had an anti-inflammatory effect on human dural fibroblasts.

[0062] FIG. 8 is a graph illustrating the anti-inflammatory effect of human dural fibroblasts according to LED wavelength and energy of a near-infrared and ultrasound-based non-invasive treatment device for migraine relief according to one embodiment of the present invention.

[0063] In the experiment of Fig. 8, protein expression was analyzed in human dural fibroblasts in the presence or absence of LPS, 1050 nm light irradiation, and ultrasound stimulation, and it was found that LPS treatment, 1050 nm light irradiation, and ultrasound stimulation had an anti-inflammatory effect on human dural fibroblasts.

[0064] FIG. 9 is a graph for explaining whether human dural fibroblasts are cytotoxic according to LED wavelength and energy of a near-infrared and ultrasound-based non-invasive treatment device for migraine relief according to an embodiment of the present invention, and FIG. 10 is a graph for explaining whether human dural fibroblasts are cytotoxic according to ultrasound stimulation of a near-infrared and ultrasound-based non-invasive treatment device for migraine relief according to an embodiment of the present invention.

[0065] As shown in Fig. 9, it can be seen that there is no problem with the cytotoxicity of human dural fibroblasts when irradiated with near-infrared light of 1050 nm after LPS treatment, and when provided with ultrasound after LPS treatment, as shown in Fig. 10.

[0066] In this way, the non-invasive treatment device according to the present invention can provide effective migraine relief while minimizing side effects for the user through a non-invasive method of reducing inflammation of human dural fibroblasts by providing near-infrared rays and ultrasound when worn on the user's head.

[0067] In addition, the near-infrared and ultrasound-based non-invasive treatment device according to the present invention can provide optimal migraine relief suitable for the user's symptoms by selectively providing ultrasound and near-infrared to the user's forehead, the left and right temple areas of the user, or the back of the user's head.

[0068] The detailed description of the present invention, as described above, has described specific embodiments. However, various modifications are possible without departing from the scope of the present invention. The technical spirit of the present invention should not be limited to the aforementioned embodiments, but should be defined not only by the claims but also by equivalents thereof.

Claims

1. Body part worn on the user's head; A plurality of function providing units installed in the above body to provide ultrasound and near-infrared rays; and A control unit that controls the provision of ultrasonic waves and near-infrared rays of the above function providing unit; A near-infrared and ultrasound-based non-invasive treatment device for migraine relief, characterized by including:

2. In claim 1, The above function providing unit, A near-infrared and ultrasound-based non-invasive treatment device for migraine relief, characterized in that it is positioned to correspond to the user's forehead area, the user's left and right temple areas, and the user's back of the head area on the body.

3. In claim 1, The above function providing unit, An ultrasonic generation module provided at the center of the above function providing unit to provide ultrasonic waves; and A near-infrared LED arranged around the above ultrasonic generation module to provide near-infrared light; A near-infrared and ultrasound-based non-invasive treatment device for migraine relief, characterized by including:

4. In claim 3, The above near-infrared LED, A near-infrared and ultrasound-based non-invasive treatment device for migraine relief, characterized in that the ultrasound generating module is arranged in a ring shape at equal intervals around the ultrasound generating module.

5. In claim 3, The above control unit, A near-infrared and ultrasound-based non-invasive treatment device for migraine relief, characterized in that each function providing unit is selectively controlled to correspond to the user's forehead area, the user's left and right temple areas, or the user's back of the head area.

6. In claim 3, The above ultrasonic generation module, Generates and provides 1 MHz ultrasound, The above near-infrared LED, A near-infrared and ultrasound-based non-invasive treatment device for migraine relief characterized by providing near-infrared light of 1050 nm.

7. In claim 1, The above body part, A near-infrared and ultrasound-based non-invasive treatment device for migraine relief, characterized by comprising an annular type band, headband hat, or mounting device corresponding to the user's head circumference.

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