Adenosine-containing eye make-up product

Abstract

Provided is an adenosine-containing eye make-up product which is less likely to run and is less likely to hurt the eyes. An adenosine-containing eye make-up product according to the present disclosure contains (A) adenosine, (B) a thickener, and (C) water, has a pH value of 6-8, and has a viscosity of 3800-40000 mPa•s at 30°C.

Description

Adenosine-containing eye cosmetics

[0001] The present disclosure relates to an adenosine-containing eye cosmetic.

[0002] Adenosine is known to promote blood circulation when applied to the skin. It is also known to have the effect of producing hair growth promoting factors in hair papilla cells. Therefore, adenosine is used in hair growth agents and the like (see, for example, Patent Document 1).

[0003] Japanese Patent Application Laid-Open No. 2022-041622

[0004] Patent Document 1 describes the application of an adenosine-containing composition to scalp and hair, but does not describe its application to the eye area, such as the base of eyelashes or eyebrows.

[0005] When adenosine-containing compositions are applied to the bases of eyelashes or eyebrows, if they drip into the eyes and sting, the user will feel uncomfortable, so it is desirable that they do not sting the eyes. Furthermore, when used around the eyes, they are also required to have the property of being less likely to drip, so as to minimize the possibility of the composition getting into the eyes or dripping from the area where the effect of adenosine is desired to be exerted, thereby reducing the effect.

[0006] The present disclosure has been made in view of the above circumstances, and an object of the present disclosure is to provide an adenosine-containing eye cosmetic that is less likely to drip and less likely to sting the eyes.

[0007] In order to solve the above problems, the present inventors conducted extensive research and found that the above problems can be solved by setting the pH and viscosity of an eye cosmetic containing adenosine, a thickener, and water within a predetermined range, and have thus completed the present disclosure. Specifically, the present disclosure provides the following.

[0008] [1] An adenosine-containing eye cosmetic composition comprising: (A) adenosine; (B) a thickener; and (C) water; wherein the pH is 6 to 8; and the viscosity at 30°C is 3,800 to 40,000 mPa·s.

[0009] [2] The adenosine-containing eye cosmetic composition according to [1], further comprising (D) at least one solubilizing agent selected from the group consisting of glycyrrhizinic acid and its salts, salicylic acid and its salts, plant extracts, and caffeine.

[0010] [3] The adenosine-containing eye cosmetic according to [1] or [2], wherein the thickener (B) contains one or both of a carboxyvinyl polymer and xanthan gum.

[0011] [4] The adenosine-containing eye cosmetic composition according to any one of [1] to [3], further comprising (E) ethanol.

[0012] [5] The adenosine-containing eye cosmetic composition according to any one of [1] to [4], further comprising (F) a polyhydric alcohol.

[0013] [6] The adenosine-containing eye cosmetic composition according to any one of [1] to [5], further comprising (G) a pH adjuster.

[0014] [7] The adenosine-containing eye cosmetic composition according to any one of [1] to [6], further comprising (H) a solubilizer.

[0015] [8] The adenosine-containing eye cosmetic composition according to any one of [1] to [7], which is a topical skin preparation to be applied to the bases of the eyelashes and eyebrows.

[0016] [9] The adenosine-containing eye cosmetic composition according to any one of [1] to [8], which is filled in a container with an applicator or a tube container.

[0017] According to the present disclosure, it is possible to provide an adenosine-containing eye cosmetic that is less likely to drip and less likely to sting the eyes.

[0018] Hereinafter, embodiments of the present disclosure will be described in detail, but the present disclosure is not limited to the following embodiments and can be implemented with appropriate modifications within the scope of the purpose of the present disclosure.

[0019] <<Adenosine-Containing Eye Cosmetic>> The adenosine-containing eye cosmetic of the present disclosure (hereinafter also referred to as the "cosmetic of the present disclosure") contains (A) adenosine, (B) a thickener, and (C) water, and has a pH of 6 to 8 and a viscosity at 30°C of 3800 to 40,000 mPa·s. By including the thickener (B) and having a viscosity at 30°C of 3800 to 40,000 mPa·s, the cosmetic is less likely to drip and the effects of adenosine are exerted. Furthermore, by having a pH of 6 to 8, the cosmetic is less likely to irritate the eyes.

[0020] The pH of the cosmetic preparation of the present disclosure is preferably 6.10 to 7.90, more preferably 6.20 to 7.30. When the pH is within the above range, the cosmetic preparation is less likely to irritate the eyes and is more likely to have an effect of inhibiting adenosine precipitation. In this specification, pH is a value measured at 25°C using a pH meter.

[0021] The viscosity of the cosmetic material of the present disclosure at 30°C is preferably 6,000 to 40,000 mPa·s, more preferably 8,000 to 38,000 mPa·s. A viscosity of 6,000 mPa·s or higher at 30°C makes it less likely to drip. Furthermore, when the cosmetic material of the present disclosure is filled into a container with an applicator, the viscosity of the cosmetic material of the present disclosure at 30°C is preferably 6,000 to 40,000 mPa·s. Furthermore, when the cosmetic material of the present disclosure is filled into a tube container, the viscosity of the cosmetic material of the present disclosure at 30°C is preferably 8,000 to 40,000 mPa·s. In this specification, the viscosity at 30°C is a value measured at 30°C using a Brookfield viscometer (rotor No. 4, rotation speed 12 rpm).

[0022] The cosmetic preparation of the present disclosure is preferably a one-phase aqueous composition. The cosmetic preparation of the present disclosure may be an emulsion containing an oily component.

[0023] <Adenosine (A)> The cosmetic material of the present disclosure contains adenosine. It is preferable that adenosine is dissolved in the cosmetic material at atmospheric pressure and 25°C (after adenosine is precipitated in a low-temperature environment (e.g., 0°C), it is preferably left standing at 25°C for 4 weeks or more). Whether adenosine is dissolved or not is determined by visual observation of the appearance.

[0024] The content of adenosine is preferably 0.1% by mass or more relative to the mass of the cosmetic of the present disclosure. The content of adenosine may be 0.2% by mass or more, 0.3% by mass or more, 0.5% by mass or more, or 0.8% by mass or more relative to the mass of the cosmetic of the present disclosure. When the content of adenosine is 0.1% by mass or more, the effective effect of adenosine is easily achieved. The content of adenosine is preferably 5% by mass or less, more preferably 3% by mass or less, even more preferably 2% by mass or less, particularly preferably 1.5% by mass or less, and most preferably 1% by mass or less relative to the mass of the cosmetic of the present disclosure. When the content of adenosine is 5% by mass or less, the effect of inhibiting adenosine precipitation is easily achieved. When it is necessary to more reliably inhibit adenosine precipitation in a low-temperature environment, the content of adenosine may be 0.5% by mass or less, 0.4% by mass or less, or 0.3% by mass or less relative to the mass of the cosmetic of the present disclosure.

[0025] <Thickener (B)> The cosmetic preparation of the present disclosure contains a thickener. The thickener is an essential component of the cosmetic preparation of the present disclosure. By incorporating an appropriate amount of thickener into the cosmetic preparation, the viscosity of the cosmetic preparation at 30°C can be adjusted to a range of 3800 to 40000 mPa·s. Examples of thickeners include gum arabic, carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (marmelo), casein, dextrin, gelatin, sodium pectinate, sodium alginate, methylcellulose, ethylcellulose, carboxymethylcellulose (CMC), hydroxyethylcellulose, hydroxypropylcellulose, polyvinyl alcohol (PVA), polyvinyl methyl ether (PVM), PVP (polyvinylpyrrolidone), sodium polyacrylate, carboxyvinyl polymer (carbomer), locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium cellulose sulfate, xanthan gum, aluminum magnesium silicate, bentonite, hectorite, aluminum magnesium silicate (veegum), laponite, silicic anhydride, taurate-based synthetic polymers, and acrylate-based synthetic polymers. Among these, it is preferable to contain one or both of a carboxyvinyl polymer and xanthan gum, as this makes it easier to obtain the effects of the present disclosure, and a carboxyvinyl polymer is more preferable, as it makes it easier to achieve a thickening effect when the pH is within the above-mentioned numerical range.

[0026] The content of the thickener is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, and even more preferably 0.3% by mass or more, relative to the mass of the cosmetic of the present disclosure. If the content is 0.1% by mass or more, the cosmetic is less likely to drip. The content of the thickener can be, for example, 3% by mass or less, 2% by mass or less, 1% by mass or less, or 0.8% by mass or less, relative to the mass of the cosmetic of the present disclosure.

[0027] <Water (C)> The cosmetic preparation of the present disclosure contains water. As the water, water used in cosmetics, quasi-drugs, etc. can be used, such as purified water, ion-exchanged water, tap water, etc.

[0028] The water content, relative to the mass of the cosmetic preparation of the present disclosure, can be, for example, 30% by mass or more, 40% by mass or more, 50% by mass or more, 60% by mass or more, 65% by mass or more, or 70% by mass or more. The water content, relative to the mass of the cosmetic preparation of the present disclosure, can be, for example, 95% by mass or less, 90% by mass or less, 85% by mass or less, or 80% by mass or less.

[0029] <Solubilizing Agent (D)> The cosmetic preparation of the present disclosure may contain at least one solubilizing agent selected from the group consisting of glycyrrhizinic acid and its salts, salicylic acid and its salts, plant extracts, and caffeine. The solubilizing agent is a component that can suppress the precipitation of adenosine dissolved in a solvent, or, even if adenosine temporarily precipitates in the cosmetic preparation in a low-temperature environment (e.g., 0°C), promote (accelerate) the re-dissolution of adenosine when the cosmetic preparation is returned to, for example, 25°C or higher. In the cosmetic preparation of the present disclosure, the solubilizing agent is dissolved in the cosmetic preparation at atmospheric pressure and 25°C. If the solubilizing agent is not soluble in the solvent, a solubilizing agent such as a surfactant can be added.

[0030] Examples of salts of glycyrrhizinic acid and salicylic acid include alkali metal salts such as sodium salt, potassium salt, and lithium salt; alkaline earth metal salts such as calcium salt and magnesium salt; ammonium salt; and amino acid salts. Of these, ammonium salts are preferred.

[0031] Examples of plant extracts include angelica tree leaf / stem extract, apricot juice, ginkgo biloba leaf extract, mandarin orange peel extract, Scutellaria root extract, Panax ginseng root extract, Rosa canina fruit extract, Ononis extract, licorice root extract, Phellodendron amurense bark extract, Sophora flavescens root extract, cherry blossom leaf extract, St. John's wort flower / leaf / stem extract, Crataegus communis flower extract, Horse chestnut seed extract, Achillea millefolium extract, Rosa centifolia flower extract, Somei Yoshino leaf extract, Camellia japonica seed extract, Camellia japonica flower extract, Tencha extract, lotus germ extract, Myrtaceae leaf extract, Bupleurum falcatum root extract, Melilot extract, Cornflower flower extract, Lemon extract, Rosemary extract, Rosemary leaf extract, Wild thyme extract, Sanguisorba officinalis extract, etc., and at least one selected from the group consisting of these is preferred. The above plant extracts are listed by their cosmetic ingredient names. Even if a plant extract has a quasi-drug ingredient name that is different from the cosmetic ingredient name, it can be included in the above plant extracts if it has the same INCI name.

[0032] Commercially available plant extracts can be used. The plant extract can be obtained by immersing the leaves, stems including rhizomes, fruits, roots, and other parts of the plant in an extraction solvent, optionally heating under reflux, and then filtering and concentrating. The extraction solvent is not limited to any solvent commonly used for extraction, and in particular, alcohols such as methanol and ethanol; hydrous alcohols; organic solvents such as acetone and ethyl acetate can be used alone or in combination, or extraction can be performed with water.

[0033] The solubilizing agent is preferably at least one selected from the group consisting of glycyrrhizinic acid and its salts, salicylic acid and its salts, apricot juice, ginkgo biloba leaf extract, licorice root extract, sophora flavescens root extract, camellia flower extract, lemon extract, wild thyme extract, burnet extract, and caffeine, and more preferably glycyrrhizinic acid and its salts.

[0034] The content of the solubilizing agent is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, even more preferably 0.005% by mass or more, particularly preferably 0.01% by mass or more, and most preferably 0.05% by mass or more, relative to the mass of the cosmetic preparation of the present disclosure. When the content of the solubilizing agent is 0.0001% by mass or more, the effect of inhibiting adenosine precipitation is easily achieved. The solubilizing agent can be added up to the solubility limit. The content of the solubilizing agent can be, for example, 1.5% by mass or less, 1% by mass or less, 0.5% by mass or less, or 0.2% by mass or less, relative to the mass of the cosmetic preparation of the present disclosure.

[0035] The content of the solubilizing agent is preferably 0.0001 parts by mass or more, more preferably 0.001 parts by mass or more, even more preferably 0.005 parts by mass or more, particularly preferably 0.01 parts by mass or more, and most preferably 0.05 parts by mass or more, relative to 1 part by mass of adenosine. When the content of the solubilizing agent is 0.0001 parts by mass or more, the effect of inhibiting adenosine precipitation is easily obtained. The content of the solubilizing agent can be, for example, 1.5 parts by mass or less, 1 part by mass or less, 0.5 parts by mass or less, or 0.2% by mass or less, relative to 1 part by mass of adenosine.

[0036] <Ethanol (E)> The cosmetic preparation of the present disclosure may contain ethanol. The ethanol content is preferably less than 20% by mass, more preferably 15% by mass or less, even more preferably 10% by mass or less, and particularly preferably 5% by mass or less, relative to the mass of the cosmetic preparation of the present disclosure. It is also possible for the cosmetic preparation to be substantially free of ethanol (0% by mass). When the ethanol content is less than 20% by mass, skin irritation can be reduced. Furthermore, the cosmetic preparation of the present disclosure can be applied to people who are hypersensitive and / or allergic to ethanol.

[0037] <Polyhydric Alcohol (F)> The cosmetic preparation of the present disclosure may contain a polyhydric alcohol, which makes it easier to obtain the effect of inhibiting the precipitation of adenosine.

[0038] Examples of polyhydric alcohols include dihydric alcohols (e.g., ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, octylene glycol, etc.); trihydric alcohols (e.g., glycerin, trimethylolpropane, etc.); tetrahydric alcohols (e.g., pentaerythritol such as 1,2,6-hexanetriol, etc.); pentahydric alcohols (e.g., xylitol, etc.); hexahydric alcohols (e.g., sorbitol, mannitol, etc.); polyhydric alcohol polymers (e.g., diethylene glycol, Examples of suitable alcohols include glycerin monoalkyl ethers (e.g., chimyl alcohol, selachyl alcohol, batyl alcohol, etc.); sugar alcohols (e.g., sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch hydrolyzed sugars, maltose, xylitol, starch hydrolyzed sugar reduced alcohols, etc.); tripolyoxypropylene glycerin ether; POP-glycerin ether; POP·POE-pentaerythritol ether, etc. Among these, dihydric alcohols and polyhydric alcohol polymers are preferred, and propylene glycol, dipropylene glycol, and 1,3-butylene glycol are more preferred.

[0039] The content of the polyhydric alcohol, relative to the mass of the cosmetic preparation of the present disclosure, can be, for example, 1% by mass or more, 5% by mass or more, 10% by mass or more, or 15% by mass or more. The content of the polyhydric alcohol, relative to the mass of the cosmetic preparation of the present disclosure, can be, for example, 50% by mass or less, 40% by mass or less, 30% by mass or less, or 25% by mass or less.

[0040] <pH Adjuster (G)> The cosmetic preparation of the present disclosure may contain a pH adjuster. Examples of pH adjusters include buffers such as lactic acid and sodium lactate, citric acid and sodium citrate, and succinic acid and sodium succinate. Of these, citric acid and sodium citrate are preferred. The content of the pH adjuster is not particularly limited as long as it is within a range that achieves the effect of pH adjustment.

[0041] <Solubilizer (H)> The cosmetic preparation of the present disclosure may contain a solubilizer, which makes it easier for components that are poorly soluble in aqueous solvents (except adenosine), such as solubilizing agents and fragrances, to dissolve in the solvent.

[0042] Examples of solubilizing agents include surfactants such as anionic surfactants, cationic surfactants, amphoteric surfactants, hydrophilic nonionic surfactants, and lipophilic nonionic surfactants. Of these, hydrophilic nonionic surfactants are preferred.

[0043] Examples of anionic surfactants include fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.); higher alkyl sulfates (e.g., sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (e.g., POE-lauryl triethanolamine sulfate, POE-lauryl sodium sulfate, etc.); N-acyl sarcosinates (e.g., sodium lauroyl sarcosinate, etc.); higher fatty acid amide sulfonates (e.g., sodium N-stearoyl-N-methyl taurate, sodium N-myristoyl-N-methyl taurate, sodium coconut oil fatty acid methyl taurate, sodium lauryl methyl taurate, etc.); phosphate salts (sodium POE-oleyl ether phosphate, sodium POE-stearyl ether phosphate, etc.); sulfosuccinates (e.g., sodium di-2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene sulfonate, sodium lauryl methyl taurate, sodium lauryl methyl taurate, etc.); sodium glycol sulfosuccinate, etc.); alkylbenzenesulfonates (e.g., sodium linear dodecylbenzenesulfonate, triethanolamine linear dodecylbenzenesulfonate, linear dodecylbenzenesulfonic acid, etc.); higher fatty acid ester sulfates (e.g., sodium hydrogenated coconut oil fatty acid glycerin sulfate, etc.); N-acylglutamates (e.g., monosodium N-lauroylglutamate, disodium N-stearoylglutamate, monosodium N-myristoyl-L-glutamate, etc.); sulfated oils (e.g., turmeric oil, etc.); POE-alkyl ether carboxylic acids; POE-alkyl allyl ether carboxylates; α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfates; higher fatty acid alkylolamide sulfates; sodium lauroylmonoethanolamide succinate; ditriethanolamine N-palmitoyl aspartate; sodium caseinate, etc.

[0044] Examples of cationic surfactants include alkyltrimethylammonium salts (e.g., stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (e.g., cetylpyridinium chloride, etc.); dialkyldimethylammonium salts (e.g., distearyldimethylammonium chloride); poly(N,N'-dimethyl-3,5-methylenepiperidinium) chloride; alkyl quaternary ammonium salts; alkyldimethylbenzylammonium salts; alkylisoquinolinium salts; dialkylmorphonium salts; POE-alkylamines; alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; benzethonium chloride, etc.

[0045] Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants (e.g., 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.); betaine-based surfactants (e.g., 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amido betaine, sulfobetaine, etc.).

[0046] Examples of hydrophilic nonionic surfactants include POE-sorbitan fatty acid esters (e.g., POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, etc.); POE-sorbitol fatty acid esters (e.g., POE-sorbitol monolaurate, POE-sorbitol monooleate, POE-sorbitol pentaoleate, POE-sorbitol monostearate, etc.); POE-glycerin fatty acid esters (e.g., POE-glycerin monostearate, POE-monooleates such as POE-glycerin monoisostearate and POE-glycerin triisostearate; POE-fatty acid esters (for example, POE-distearate, POE-monodioleate, ethylene glycol distearate, etc.); POE-alkyl ethers (for example, POE-lauryl ether, POE-oleyl ether, POE-stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE-cholestanol ether, etc.); Pluronic® type (for example, Pluronic (registered trademark), etc.); POE·POP-alkyl ethers (for example, POE·POP-cetyl ether, POE·POP-2-decyltetradecyl ether, POE·POP-monobutyl ether, POE·POP-hydrogenated lanolin, POE·POP-glycerin ether, etc.); tetraPOE·tetraPOP-ethylenediamine condensates (for example, Tetronic, etc.); POE-castor oil hydrogenated castor oil derivatives (for example, POE-castor oil, POE-hydrogenated castor oil, POE-hydrogenated castor oil monoisostearate, POE-hydrogenated castor oil triisostearate, Examples of the esters include POE-hydrogenated castor oil monopyroglutamic acid monoisostearate diester, POE-hydrogenated castor oil maleic acid, etc.; POE-beeswax / lanolin derivatives (for example, POE-sorbitol beeswax, etc.); alkanolamides (for example, coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE-propylene glycol fatty acid esters; POE-alkylamines; POE-fatty acid amides; sucrose fatty acid esters; alkylethoxydimethylamine oxide; and trioleyl phosphate.Of these, POE·POP-alkyl ether is preferred, and POE·POP-2-decyltetradecyl ether is more preferred.

[0047] Examples of lipophilic nonionic surfactants include sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, etc.); glycerin polyglycerin fatty acids (e.g., glycerin monocottonseed oil fatty acid, glycerin monoerucate, glycerin sesquioleate, glycerin monostearate, glycerin α,α'-oleic acid pyroglutamate, glycerin monostearate malate, etc.); propylene glycol fatty acid esters (e.g., propylene glycol monostearate, etc.); hydrogenated castor oil derivatives; and glycerin alkyl ethers.

[0048] The solubilizer may be added in an amount necessary to dissolve components insoluble in the aqueous solvent. A low solubilizer content is preferred to reduce skin irritation and prevent stickiness upon application. For example, the solubilizer content is preferably 1% by mass or less relative to the mass of the cosmetic preparation of the present disclosure. The solubilizer content may be, for example, 0.0001% by mass or more, 0.001% by mass or more, or 0.01% by mass or more relative to the mass of the cosmetic preparation of the present disclosure.

[0049] <Other Components> The cosmetic composition of the present disclosure may contain other components, such as neutralizing agents, water-soluble alcohols, oily components, powders, moisturizing agents, film-forming agents, oil-soluble UV absorbers, water-soluble UV absorbers, sequestering agents, amino acids, organic amines, polymer emulsions, skin nutrients, vitamins, antioxidants, antioxidant aids, fragrances, and the like, as needed, within the scope of not impairing the effects of the present disclosure.

[0050] Examples of the neutralizing agent include potassium hydroxide, sodium hydroxide, etc. The content of the neutralizing agent is not particularly limited as long as it is within a range in which the desired pH can be obtained.

[0051] Examples of the water-soluble alcohol include at least one selected from lower alcohols, polyhydric alcohols, polyhydric alcohol polymers, dihydric alcohol alkyl ethers, dihydric alcohol alkyl ethers, dihydric alcohol ether esters, glycerin monoalkyl ethers, sugar alcohols, monosaccharides, oligosaccharides, polysaccharides, and derivatives thereof.

[0052] Examples of the lower alcohol include propanol, isopropanol, isobutyl alcohol, and t-butyl alcohol.

[0053] Examples of monosaccharides include trioses (e.g., D-glyceryl aldehyde, dihydroxyacetone, etc.), tetraoses (e.g., D-erythrose, D-erythrulose, D-threose, erythritol, etc.), pentoses (e.g., L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L-xylulose, etc.), hexoses (e.g., D-glucose, D-talose, D-psicose, D-galactose, D-fructose, L-galactose, L-mannose, and D-tagatose, etc.), heptoses (e.g., aldoheptose, heptulose, etc.), octose (e.g., octulose, etc.), deoxysugars (e.g., 2-deoxy-D-ribose, 6-deoxy-L-galactose, 6-deoxy-L-mannose, etc.), aminosugars (e.g., D-glucosamine, D-galactosamine, sialic acid, aminouronic acid, muramic acid, etc.), uronic acids (e.g., D-glucuronic acid, D-mannuronic acid, L-guluronic acid, D-galacturonic acid, L-iduronic acid, etc.), etc.

[0054] Examples of oligosaccharides include at least one selected from sucrose, gunthianose, umbelliferose, lactose, planteose, isolychnoses, α,α-trehalose, raffinose, lychnoses, umbilicin, stachyose, verbascoses, and the like.

[0055] Examples of polysaccharides include at least one selected from cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum, dextran, keratosulfate, locust bean gum, succinoglucan, and caronic acid.

[0056] Examples of other polyols include at least one selected from polyoxyethylene methyl glucoside (Glucam E-10), polyoxypropylene methyl glucoside (Glucam P-10), and the like.

[0057] As the oily component, for example, liquid oils and fats, solid oils and fats, wax, hydrocarbons, higher fatty acids, higher alcohols, synthetic ester oils, silicone oils, etc. can be used.

[0058] Examples of liquid oils and fats include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, camellia oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, Chinese tung oil, Japanese tung oil, jojoba oil, germ oil, and triglycerin.

[0059] Examples of solid fats and oils include cacao butter, coconut oil, horse fat, hardened coconut oil, palm oil, beef tallow, mutton tallow, hardened beef tallow, palm kernel oil, lard, beef bone fat, Japan wax kernel oil, hardened oil, beef trotter fat, Japan wax, and hardened castor oil.

[0060] Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ivory wax, whale wax, montan wax, rice bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, and POE hydrogenated lanolin alcohol ether.

[0061] Examples of hydrocarbon oils include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, and microcrystalline wax.

[0062] Examples of higher alcohols that can be used include straight-chain alcohols (e.g., lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, etc.); branched-chain alcohols (e.g., monostearyl glycerin ether (batyl alcohol), 2-decyltetradecynol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol, etc.); and the like.

[0063] Examples of synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid esters, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, tri-2 -Glycerin ethylhexanoate, triethylhexanoin, glycerin trioctanoate, glycerin triisopalmitate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glycerin trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleyl oleate, acetoglyceride, palmitic acid 2- heptylundecyl, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, triethyl citrate, and the like.

[0064] Examples of silicone oils include silicone compounds such as dimethylpolysiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, stearoxymethylpolysiloxane, polyether-modified organopolysiloxane, fluoroalkyl-polyoxyalkylene-co-modified organopolysiloxane, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, fluorine-modified organopolysiloxane, amino-modified organopolysiloxane, silicone gel, acrylic silicone, trimethylsiloxysilicate, and silicone RTV rubber.

[0065] Examples of powders include inorganic powders (e.g., talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, lepidolite, biotite, lithia mica, calcined mica, calcined talc, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, silica, zeolite, glass, barium sulfate, calcined calcium sulfate (calcined gypsum), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, metal soap (e.g., zinc myristate, calcium palmitate, aluminum stearate), boron nitride, etc.); organic powders (e.g., polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, silicone resin powder, silk powder, wool powder, urethane powder, etc.); inorganic white pigments (for example, titanium dioxide, zinc oxide, etc.); inorganic red pigments (for example, iron oxide (red iron oxide), iron titanate, etc.); inorganic brown pigments (for example, γ-iron oxide, etc.), inorganic yellow pigments (yellow iron oxide, ochre, etc.), inorganic black pigments (black iron oxide, carbon black, low-order titanium oxide, etc.), inorganic purple pigments (for example, manganese violet, cobalt violet, etc.); inorganic green pigments (for example, chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (for example, ultramarine, Prussian blue, etc.); pearl pigments (for example, titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored titanium oxide-coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (for example, aluminum powder, copper powder, etc.);Organic pigments such as zirconium, barium or aluminum lakes (e.g., organic pigments such as Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, and Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3, and Blue No. 1, etc.); natural pigments (e.g., chlorophyll, β-carotene, etc.); wax powders (e.g., carnauba wax powder, etc.); starch powders (e.g., corn starch powder, rice starch powder, etc.);

[0066] Examples of natural water-soluble polymers include plant-derived polymers (e.g., gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (marmella), algae colloid (cassowia extract), starch (rice, corn, potato, wheat), glycyrrhizic acid); microbial-derived polymers (e.g., xanthan gum, dextran, succinoglucan, pullulan, etc.); and animal-derived polymers (e.g., collagen, casein, albumin, gelatin, etc.).

[0067] Examples of semi-synthetic water-soluble polymers include starch-based polymers (e.g., carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose-based polymers (methyl cellulose, ethyl cellulose, methylhydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, etc.); and alginic acid-based polymers (e.g., sodium alginate, propylene glycol alginate, etc.).

[0068] Examples of wetting agents include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, alkylene oxide derivatives, short-chain soluble collagen, diglycerin (EO)PO adduct, Rosa robur extract, yarrow extract, melilot extract, and the like.

[0069] Examples of coating agents include anionic coating agents (e.g., (meth)acrylic acid / (meth)acrylic acid ester copolymers, methyl vinyl ether / maleic anhydride polymers, etc.), cationic coating agents (e.g., cationized cellulose, dimethyldiallylammonium chloride polymers, dimethyldiallylammonium chloride / acrylamide copolymers, etc.), and nonionic coating agents (e.g., polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl acetate, polyacrylic acid ester copolymers, (meth)acrylamide, polymeric silicone, silicone resins, trimethylsiloxysilicate, etc.).

[0070] Examples of oil-soluble ultraviolet absorbers include benzoic acid-based ultraviolet absorbers (e.g., para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N,N-dipropoxy PABA ethyl ester, N,N-diethoxy PABA ethyl ester, N,N-dimethyl PABA ethyl ester, N,N-dimethyl PABA butyl ester, N,N-dimethyl PABA ethyl ester, diethylaminohydroxybenzoylhexyl benzoate, etc.); anthranilic acid-based ultraviolet absorbers (e.g., homomenthyl-N-acetylanthranilate, etc.); salicylic acid-based ultraviolet absorbers (e.g., benzoic acid monoglycerides, benzoic acid di ... cinnamic acid-based ultraviolet absorbers (e.g., ethylhexyl salicylate, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, homosalate, etc.); cinnamic acid-based ultraviolet absorbers (e.g., octyl methoxycinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methyl 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-di-para-methoxycinnamate, etc.); 3-(4'-methyl 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenyl)benzotriazole; dibenzalazine; dianisoylmethane; 4-methoxy-4'-t-butyldibenzoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one, dimorpholinopyridazinone;2-ethylhexyl-2-cyano-3,3-diphenylacrylate (octocrellin); 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-(1,3,5)-triazine, benzophenone-based ultraviolet absorbers (e.g., 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4 , 4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc.);

[0071] Examples of the water-soluble ultraviolet absorber include benzophenone-based ultraviolet absorbers (e.g., 2-hydroxy-4-methoxybenzophenone-5-sulfonate, etc.), benzylidene camphor-based ultraviolet absorbers (benzylidene camphorsulfonic acid, terephthalidenedicamphorsulfonic acid, etc.), and phenylbenzimidazole-based ultraviolet absorbers (phenylbenzimidazolesulfonic acid, etc.).

[0072] Examples of sequestering agents include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, and trisodium ethylenediaminehydroxyethyltriacetate.

[0073] Examples of amino acids include neutral amino acids (e.g., threonine, cysteine, etc.) and basic amino acids (e.g., hydroxylysine, etc.). Examples of amino acid derivatives include sodium acyl sarcosine (sodium lauroyl sarcosine), acyl glutamate, sodium acyl β-alanine, glutathione, pyrrolidone carboxylic acid, etc.

[0074] Examples of amino acids include neutral amino acids (e.g., threonine, cysteine, etc.) and basic amino acids (e.g., hydroxylysine, etc.). Examples of amino acid derivatives include sodium acyl sarcosine (sodium lauroyl sarcosine), acyl glutamate, sodium acyl β-alanine, glutathione, pyrrolidone carboxylic acid, etc.

[0075] Examples of organic amines include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol.

[0076] Examples of polymer emulsions include acrylic resin emulsion, polyethyl acrylate emulsion, acrylic resin liquid, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, and natural rubber latex.

[0077] Examples of vitamins include vitamins A, B1, B2, B6, C, E and their derivatives, pantothenic acid and its derivatives, biotin, etc.

[0078] Examples of antioxidants include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, and gallic acid esters.

[0079] Examples of antioxidant aids include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

[0080] Other ingredients that can be added include, for example, preservatives (ethylparaben, butylparaben, chlorphenesin, phenoxyethanol, etc.); anti-inflammatory agents (for example, glycyrrhizinic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); whitening agents (for example, placenta extract, saxifrage extract, arbutin, etc.); various extracts (for example, Phellodendron bark, Coptis chinensis, Lithospermum root, Peony, Swertia japonica, Birch, Sage, Loquat, Carrot, Aloe, Mallow, Iris, Grape, Job's tears, Loofah, Lily, Saffron, Cnidium rhizome, Ginger, Hypericum perforatum, Ononis, Garlic, Capsicum, Citrus fruit, Tomato, float, seaweed, etc.), activators (for example, royal jelly, photosensitizers, cholesterol derivatives, etc.); blood circulation promoters (for example, nonylic acid vanillylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, cantharides tincture, ichthammol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, etc.); antiseborrheic agents (for example, sulfur, thianthol, etc.); anti-inflammatory agents (for example, tranexamic acid, thiotaurine, hypotaurine, etc.).

[0081] The cosmetic composition of the present disclosure is for use around the eyes and can be used as an external skin preparation for application around the eyes, particularly to the bases of the eyelashes and eyebrows. In this specification, the term "around the eyes" refers to the area from the periphery of the eyes to the periphery of the eyebrows. Furthermore, the bases of the eyelashes and eyebrows specifically refer to the skin around the bases of the eyelashes and eyebrows, as well as the cells (such as hair papilla cells) at the bases of the eyelashes and eyebrows. The cosmetic composition of the present disclosure is particularly suitable for application around the eyes to the bases of the eyelashes and eyebrows because it is resistant to dripping and stinging the eyes. However, those skilled in the art will readily understand that the cosmetic composition of the present disclosure can also be applied to the scalp.

[0082] Since the cosmetic composition of the present disclosure is intended for use around the eyes and has a relatively high viscosity so as to prevent dripping, it is preferably filled in a container with an applicator (such as a brush or writing brush) or a tube container. In the case of a container with an applicator, for example, the cosmetic composition in the container is applied to the applicator and then applied to the eyes. In the case of a tube container, for example, the cosmetic composition in the container is taken up in the hand and applied to the eyes.

[0083] Examples of the method for producing the cosmetic preparation of the present disclosure include a method in which a solubilizing agent is dissolved in an aqueous solvent containing water, and then adenosine is further added and dissolved. The order of addition of each component, including other components, is not particularly limited as long as adenosine can be dissolved. Adenosine is preferably dissolved in an aqueous solvent at 25°C or higher.

[0084] The present disclosure will be described in more detail based on examples, but the present disclosure is not limited to these examples.

[0085] [Examples 1 to 12 and Comparative Examples 1 to 5] Cosmetics were prepared by mixing the types and amounts of components shown in Tables 1 and 2 at 25°C. The units of amounts are % by mass. The products in which some of the components were used are shown below.

[0086] PPG-13 Decyltetradeceth-24: S-safe 1324D (POE·POP-2-decyltetradecyl ether) manufactured by NOF Corporation. Xanthan gum: Keltrol (registered trademark) manufactured by Kelco. Carbomer: Carbopol (registered trademark) 980 (carboxyvinyl polymer) manufactured by Lubrizol Corporation.

[0087] The pH value and viscosity of the prepared cosmetics were measured. The prepared cosmetics were also evaluated as follows. The results are shown in Tables 1 and 2. Note that the viscosity of the cosmetic of Comparative Example 1 was very low and could not be measured using the method described herein (estimated to be less than 1,300 mPa s, as in Comparative Example 4).

[0088] <Precipitation Suppression> Immediately after preparation, the cosmetic was a one-phase aqueous composition, and adenosine and the solubilizing agent were dissolved in the cosmetic. The prepared cosmetic was left standing at 0°C for 3 weeks, and visually inspected to see if any precipitates had formed in the cosmetic. Next, the cosmetic that had been left standing at 0°C for 3 weeks was left standing at 25°C for 6 days, and visually inspected to see if any precipitates remained in the cosmetic (if any precipitates had redissolved). The test results were evaluated according to the following criteria. ○: No precipitates formed even immediately after leaving at 0°C for 3 weeks. △: Precipitates formed immediately after leaving at 0°C for 3 weeks, but the precipitates naturally redissolved after leaving at 25°C for 6 days. ×: Precipitates remained even after leaving at 25°C for 6 days.

[0089] <Dripping Resistance> The prepared cosmetics were used by professional panelists (10 women), who evaluated whether or not dripping occurred according to the following criteria: ◯: None of the 10 panelists experienced any dripping. △: No dripping occurred in 7 to 9 panelists, but dripping occurred in 1 to 3 panelists. ×: Dripping occurred in 4 or more panelists.

[0090] <Lack of Eye Irritation> The prepared cosmetics were used by professional panelists (10 women), who evaluated whether they felt it irritated their eyes according to the following criteria: ○: 8 or more people felt it did not irritate their eyes ×: 3 or more people felt it irritated their eyes

[0091]

[0092]

[0093] As shown in Tables 1 and 2, the cosmetics of the Examples, which contain adenosine, a thickener, and water and have pH and viscosity within the specified ranges, are less likely to drip and irritate the eyes. On the other hand, the cosmetics of the Comparative Examples, which have pH and viscosity outside the specified ranges, are more likely to drip and irritate the eyes. Furthermore, the cosmetics of Examples 1 to 11, which contain a solubilizer or have an adenosine content of 0.5% by mass or less, are able to suppress the precipitation of adenosine.

Claims

1. An eye cosmetic containing adenosine, comprising: (A) adenosine, (B) a thickener, and (C) water, having a pH of 6 to 8 and a viscosity at 30°C of 3,800 to 40,000 mPa·s.

2. The adenosine-containing eye cosmetic according to claim 1, further comprising at least one solubilizing agent selected from the group consisting of (D) glycyrrhizic acid and its salts, salicylic acid and its salts, plant extracts, and caffeine.

3. The adenosine-containing eye cosmetic according to claim 1, wherein the thickener (B) contains one or both of carboxyvinyl polymer and xanthan gum.

4. The adenosine-containing eye cosmetic according to claim 1, further comprising (E) ethanol.

5. The adenosine-containing eye cosmetic according to claim 1, further comprising (F) polyhydric alcohol.

6. The adenosine-containing eye cosmetic according to claim 1, further comprising (G) a pH adjuster.

7. The adenosine-containing eye cosmetic according to claim 1, further comprising (H) a solubilizer.

8. The adenosine-containing eye cosmetic according to any one of claims 1 to 7, which is a topical skin preparation for application to the bases of eyelashes and eyebrows.

9. The adenosine-containing eye cosmetic according to claim 8, filled in a container with an applicator or a tube container.

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