Quinazoline dione compounds and uses thereof

Abstract

Provided herein are quinazolinone dione compounds for modulating muscle myosin to treat obesity and related disorders such as cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, cancer, and osteoarthritis.

Description

Attorney Docket No.52600-737601 QUINAZOLINONE DIONE COMPOUNDS AND USES THEREOF CROSS-REFERENCE

[0001] This application claims the benefit of U.S. Provisional Patent Application No. 63 / 570,142,filed March 26, 2024, which is incorporated herein by reference in its entirety. This application claims the benefit of U.S. Provisional Patent Application No.63 / 702,603, filed October 2, 2024, which is incorporated herein by reference in its entirety. BACKGROUND OF THE INVENTION

[0002] Obesity is a medical condition involving excess body fat accumulated to such an extent that itcan potentially have negative effects on health. Obesity is a major cause of disability and is correlated with various diseases and conditions, particularly cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis. Obesity is a leading preventable cause of death worldwide, with increasing rates in adults and children. In 2022, over 1 billion people were obese worldwide. Excess body fat underlies 64% of cases of diabetes in men and 77% of cases in women. SUMMARY OF THE INVENTION

[0003] The disclosure provides compound and salts thereof for use in treating disease. In certainaspects, the disclosure provides a compounds and salts of Formula (I), (I-A). (II), (III), (III-A), (IV), (V), (V-A), (VI), and (VII) pharmaceutical compositions thereof, as well as methods of use in the treatment of disease. In some embodiments, disclosed herein is a method of treating metabolic disease, diabetes, a neuromuscular condition, a skeletal muscular condition, sarcopenia, muscle wasting, muscle spasm, inducing weight loss, or of inducing muscle gain in an individual in need thereof, the method comprising administering a therapeutically effective amount of a compound of Formula (I), (I-A). (II), (III), (III-A), (IV), (V), (V-A), (VI), or (VII). INCORPORATION BY REFERENCE

[0004] All publications, patents, and patent applications mentioned in this specification are hereinincorporated by reference to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference. DETAILED DESCRIPTION OF THE INVENTION

[0005] In certain aspects, the disclosure provides methods for treating metabolic disease, diabetes, aneuromuscular condition, a skeletal muscular condition, sarcopenia, muscle wasting, muscle spasm, inducing weight loss, or of inducing muscle gain in an individual in need thereof, the methodAttorney Docket No.52600-737601 comprising administering a therapeutically effective amount of a compound of Formula (I), (I-A). (II), (III), (III-A), (IV), (V), (V-A), (VI), or (VII). Definitions

[0006] Unless defined otherwise, all technical and scientific terms used herein have the samemeaning as is commonly understood by one of skill in the art to which this invention belongs.

[0007] As used in the specification and claims, the singular form “a”, “an” and “the” includes pluralreferences unless the context clearly dictates otherwise.

[0008] The term “Cx-y” or “Cx-Cy” (e.g., when used in conjunction with a chemical moiety, such asalkyl, alkenyl, or alkynyl) is meant to include groups that comprise a number of carbon atoms greater than or equal to x carbon atoms and less than or equal to y carbon atoms in the chemical moiety, subject to the following. The term “Cx-y” or “Cx-Cy” is not meant to limit the number of carbon atoms which may be attached to the chemical moiety when the chemical moiety is substituted with a second chemical moiety. For example, the term “C1-6alkyl” or “C1to C6alkyl” refers to saturated, substituted or unsubstituted, hydrocarbon groups, including straight-chain alkyl groups (e.g., linear alkyl groups) and branched alkyl groups that contain 1, 2, 3, 4, 5, or 6 carbon atoms, plus however many carbon atoms may be present in any substituents of the C1-6alkyl. For example, if a C1-6alkyl is optionally substituted with a second chemical moiety comprising two carbon atoms, then it will be understood that the C1-6 alkyl can include between 1 and 8 carbon atoms.

[0009] The terms “Cx-yalkenyl” and “Cx-yalkynyl” refer to substituted or unsubstituted unsaturatedaliphatic groups analogous in length and possible substitution to the alkyls described above, but that contain at least one double or triple bond, respectively.

[0010] "Amino" refers to the –NH2 moiety.

[0011] "Cyano" refers to the -CN moiety.

[0012] "Nitro" refers to the -NO2 moiety.

[0013] "Oxa" refers to the -O- moiety.

[0014] "Oxo" refers to the =O moiety.

[0015] "Thioxo" refers to the =S moiety.

[0016] "Imino" refers to the =N-H moiety.

[0017] "Oximo" refers to the =N-OH moiety.

[0018] "Hydrazino" refers to the =N-NH2 moiety.

[0019] "Alkyl" refers to a straight (e.g., linear) or branched (e.g., nonlinear) hydrocarbon moietyconsisting solely of carbon and hydrogen atoms, fully saturated. In certain embodiments, “alkyl” comprises one to fifteen carbon atoms (e.g., C1-C15alkyl). In certain embodiments, an alkylAttorney Docket No.52600-737601 comprises one to thirteen carbon atoms (e.g., C1-C13alkyl). In certain embodiments, an alkyl comprises one to eight carbon atoms (e.g., C1-C8 alkyl). In certain embodiments, an alkyl comprises one to six carbon atoms (e.g., C1-C6 alkyl). In other embodiments, an alkyl comprises one to five carbon atoms (e.g., C1-C5alkyl). In other embodiments, an alkyl comprises one to four carbon atoms (e.g., C1-C4 alkyl). In other embodiments, an alkyl comprises one to three carbon atoms (e.g., C1-C3 alkyl). In other embodiments, an alkyl comprises one to two carbon atoms (e.g., C1-C2 alkyl). In other embodiments, an alkyl comprises one carbon atom (e.g., C1alkyl, e.g., methyl). In other embodiments, an alkyl comprises five to fifteen carbon atoms (e.g., C5-C15 alkyl). In other embodiments, an alkyl comprises five to eight carbon atoms (e.g., C5-C8 alkyl). In other embodiments, an alkyl comprises two to five carbon atoms (e.g., C2-C5alkyl). In other embodiments, an alkyl comprises three to five carbon atoms (e.g., C3-C5alkyl). In other embodiments, the alkyl group is selected from methyl, ethyl, 1-propyl (n-propyl), 1-methylethyl (2-propyl, iso-propyl), 1- butyl (n-butyl), 1-methylpropyl (sec-butyl), 2-methylpropyl (iso-butyl), 1,1-dimethylethyl (tert-butyl), and 1-pentyl (n-pentyl). The alkyl is attached to the rest of the molecule by a single bond.

[0020] “Aminoalkyl” refers to a moiety bonded through a nitrogen atom of the form –N(H)(alkyl) orN(alkyl)(alkyl), wherein when the moiety is N(alkyl)(alkyl), the two alkyl groups bonded to nitrogen can be the same alkyl groups or different alkyl groups.

[0021] "Alkoxy" refers to a moiety bonded through an oxygen atom of the formula –O-alkyl, wherealkyl is an alkyl chain as defined above.

[0022] "Alkenyl" refers to a straight (e.g., linear) or branched (e.g., nonlinear) hydrocarbon moietyconsisting solely of carbon and hydrogen atoms, the moiety comprising at least one carbon-carbon double bond. In certain embodiments, an alkenyl comprises two to twelve carbon atoms. In certain embodiments, an alkenyl comprises two to eight carbon atoms. In other embodiments, an alkenyl comprises two to four carbon atoms. The alkenyl is attached to the rest of the molecule by a single bond, for example, ethenyl (e.g., vinyl), prop-1-enyl (e.g., allyl), but-1-enyl, pent-1-enyl, penta-1,4-dienyl, and the like.

[0023] "Alkynyl" refers to a straight (e.g., linear) or branched (e.g., nonlinear) hydrocarbon moietyconsisting solely of carbon and hydrogen atoms, the moiety comprising at least one carbon-carbon triple bond. In some embodiments, an alkynyl comprises from two to twelve carbon atoms. In some embodiments, an alkynyl optionally further comprises at least one carbon-carbon double bond. In certain embodiments, an alkynyl comprises two to eight carbon atoms. In other embodiments, an alkynyl comprises two to six carbon atoms. In other embodiments, an alkynyl comprises two to fourAttorney Docket No.52600-737601 carbon atoms. The alkynyl is attached to the rest of the molecule by a single bond, for example, ethynyl, propynyl, butynyl, pentynyl, hexynyl, and the like.

[0024] “Alkylene” or “alkylene chain” refers to a linear (e.g., straight), or branched (e.g., nonlinear),divalent, hydrocarbon moiety. An “alkylene” or “alkylene chain” can link a portion of the molecule to a second moiety. An “alkylene” or “alkylene chain” consists solely of carbon and hydrogen atoms (substitution of an alkylene with one or more substituents comprising atoms other than hydrogen, such as N, O, and S, may be specified). An “alkylene” or “alkylene chain” can contain no unsaturation (notwithstanding the points of attachment of an alkylene to the rest of the molecule). Incertain embodiments, the “alkylene” or “alkylene chain” comprises one to twelve carbon atoms, forexample, methylene, ethylene, propylene, n-butylene, and the like. The alkylene chain can be attached to the portion of the molecule through a single bond and to the second moiety through a single bond. The points of attachment of an alkylene chain to the rest of the molecule and to the second moiety can be through one carbon atom in the alkylene chain or can be through any two carbon atoms within the alkylene. In certain embodiments, an alkylene comprises one to eight carbon atoms (e.g., C1-C8 alkylene). In other embodiments, an alkylene comprises one to five carbon atoms (e.g., C1-C5 alkylene). In other embodiments, an alkylene comprises one to four carbon atoms (e.g., C1-C4alkylene). In other embodiments, an alkylene comprises one to three carbon atoms (e.g., C1-C3alkylene). In other embodiments, an alkylene comprises one to two carbon atoms (e.g., C1-C2 alkylene). In other embodiments, an alkylene comprises one carbon atom (e.g., C1 alkylene). In other embodiments, an alkylene comprises five to eight carbon atoms (e.g., C5-C8alkylene). In other embodiments, an alkylene comprises two to five carbon atoms (e.g., C2-C5alkylene). In other embodiments, an alkylene comprises three to five carbon atoms (e.g., C3-C5 alkylene).

[0025] "Alkenylene" or "alkenylene chain" refers to a linear (e.g., straight), or branched, divalent,hydrocarbon moiety. An "alkenylene" or "alkenylene chain" can link a portion of the molecule to a second moiety. An "alkenylene" or "alkenylene chain" consists solely of carbon and hydrogen atoms (substitution of an alkenylene with one or more substituents comprising atoms other than hydrogen, such as N, O, and S, may be specified). An "alkenylene" or "alkenylene chain" comprises at least one carbon-carbon double bond. In certain embodiments, an "alkenylene" or "alkenylene chain" comprises from two to twelve carbon atoms. The alkenylene chain can be attached to the portion of the molecule through a single bond and to the second moiety through a single bond. The points of attachment of an alkenylene chain to the rest of the molecule and to the second moiety can be through one carbon atom in the alkenylene chain or through any two carbon atoms within the alkenylene chain. In certain embodiments, an alkenylene comprises two to eight carbon atoms (e.g., C2-C8alkenylene). In other embodiments, an alkenylene comprises two to five carbon atoms (e.g.,Attorney Docket No.52600-737601 C2-C5alkenylene). In other embodiments, an alkenylene comprises two to four carbon atoms (e.g., C2-C4 alkenylene). In other embodiments, an alkenylene comprises two to three carbon atoms (e.g., C2-C3 alkenylene). In other embodiments, an alkenylene comprises five to eight carbon atoms (e.g., C5-C8alkenylene). In other embodiments, an alkenylene comprises two to five carbon atoms (e.g., C2-C5 alkenylene). In other embodiments, an alkenylene comprises three to five carbon atoms (e.g., C3-C5 alkenylene).

[0026] "Alkynylene" or "alkynylene chain" refers to a linear (e.g., straight), or branched, divalent,hydrocarbon moiety. An “alkynylene" or "alkynylene chain" can link a portion of the molecule to a second moiety. An “alkynylene" or "alkynylene chain" consists solely of carbon and hydrogen (substitution of an alkynylene with one or more substituents comprising atoms other than hydrogen, such as N, O, and S, may be specified). An “alkynylene" or "alkynylene chain" comprises at least one carbon-carbon triple bond. In certain embodiments, an “alkynylene" or "alkynylene chain" comprises from two to twelve carbon atoms. An alkynylene chain can be attached to the portion of the molecule through a single bond and to the second moiety through a single bond. The points of attachment of an alkynylene chain to the rest of the molecule and to the second moiety can be through one carbon atom in the alkynylene chain or through any two carbon atoms within the alkynylene chain. In certain embodiments, an alkynylene comprises two to eight carbon atoms (e.g., C2-C8 alkynylene). In other embodiments, an alkynylene comprises two to five carbon atoms (e.g., C2-C5 alkynylene). In other embodiments, an alkynylene comprises two to four carbon atoms (e.g., C2-C4alkynylene). In other embodiments, an alkynylene comprises two to three carbon atoms (e.g., C2-C3alkynylene). In other embodiments, an alkynylene comprises two carbon atoms (e.g., C2alkynylene). In other embodiments, an alkynylene comprises five to eight carbon atoms (e.g., C5-C8 alkynylene). In other embodiments, an alkynylene comprises three to five carbon atoms (e.g., C3-C5 alkynylene).

[0027] The term “carbocycle” as used herein refers to a saturated or unsaturated (e.g., aromatic ornonaromatic unsaturated) ring or ring system in which each atom of the ring is carbon. The term “carbocycle” comprises “aryls,” “cycloalkenyls,” and “cycloalkyls.” For example, the term “carbocycle” includes 3- to 12-membered monocyclic rings (e.g., 3- to 10- membered monocyclic rings) and 4- to 20-membered polycyclic ring systems (e.g., 5- to 15-membered spiro polycyclic ring systems, 5- to 15-membered bridged polycyclic ring systems, or 4- to 15-membered fused polycyclic ring systems). For example, carbocycle includes 4- to 15-membered bicyclic rings (e.g., 5- to 15- membered spiro bicycles, 5- to 15-membered bridged bicyclic ring systems, or 4- to 15-membered fused bicyclic ring systems). For example, carbocycle includes tricyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, carbocycle includes tetracyclic ringAttorney Docket No.52600-737601 systems, which may be bridged, fused, spiro, or a combination thereof. For example, carbocycle includes ring systems that are both fused and bridged; ring systems that are both fused and spiro; ring systems that are both bridged and spiro; and ring systems that are both fused and bridged and are also spiro. Each ring of a polycyclic carbocycle may be selected from saturated and unsaturated (e.g., aromatic or nonaromatic unsaturated) rings. In an exemplary embodiment, an aromatic ring (e.g., phenyl) of a polycyclic carbocycle may be fused to a saturated or unsaturated ring (e.g., cyclohexane, cyclopentane, cyclohexene, or phenyl). A polycyclic carbocycle includes any combination of saturated and unsaturated (e.g., aromatic or nonaromatic unsaturated)rings, as valence permits. For example, polycyclic carbocycles can be spiro bicyclic rings, such as spiropentane. For example, a polycyclic carbocycle includes any combination of ring sizes such as 2-2 spiro ring systems (e.g., spiro[2.2]pentane), 3-3 spiro ring systems, 4-4 spiro ring systems, 4-5 fused ring systems (e.g., bicyclo[4.5.0] fused ring systems), 5-5 fused ring systems, 5-6 fused ring systems, 6-6 fused ring systems (e.g., naphthalene), 5-7 fused ring systems, 6-7 fused ring systems, 5-8 fused ring systems, and 6-8 fused ring systems. Exemplary carbocycles include cyclopentyl, cyclohexyl, cyclohexenyl, adamantyl, phenyl, indanyl, naphthyl, trans-bicyclo[4.4.0]decane, cis-bicylo[4.4.0]decane, spiro[3.4]octane, fluoranthene, and bicyclo[1.1.1]pentanyl. In some embodiments, a carbocycle may be bridged, fused, spiro, or any combination thereof. In some embodiments, a carbocycle is a bridged carbocycle. In some embodiments, a carbocycle is a fused carbocycle. In some embodiments, a carbocycle is a spiro carbocycle. In some embodiments, a carbocycle is a bridged and fused carbocycle. In some embodiments, a carbocycle is a bridged and spiro carbocycle. In some embodiments, a carbocycle is a fused and spiro carbocycle. In some embodiments, a carbocycle is a bridged, fused and spiro carbocycle.

[0028] The term “aryl” refers to an aromatic monocyclic or aromatic polycyclic hydrocarbon ringsystem comprising at least one cyclic, delocalized (4n+2) π-electronic system, wherein n is an integer greater than or equal to 0, in accordance with Hückel theory. In some embodiments, the aromatic monocyclic or aromatic polycyclic hydrocarbon ring system comprises only hydrogen atoms and carbon atoms. In some embodiments, the aromatic monocyclic or polycyclic system contains from three to twenty carbon atoms. In some embodiments, at least one of the rings in the polycyclic aromatic ring system is aromatic. In some embodiments, the aromatic monocyclic or aromatic polycyclic hydrocarbon ring system comprises a cyclic, delocalized (4n+2) π-electronic system in accordance with Hückel theory. In some embodiments, the ring system from which aryl groups are derived include, but are not limited to, groups such as benzene, fluorene, indane, indene, anthracene, tetralin, and naphthalene. In some embodiments, the aryl substituent is not charged (e.g., neutral). In some embodiments, the aryl substituent bears no charges. In some embodiments, the arylAttorney Docket No.52600-737601 substituent bears no net charge. In some embodiments, the aryl substituent bears no net charge and is not zwitterionic. In some embodiments, none of the carbon atoms of the aryl substituent are charged. In some embodiments, none of the carbon atoms of the aryl substituent are charged.

[0029] The term "cycloalkyl" refers to a saturated ring in which each atom of the ring is carbon.Cycloalkyl may include monocyclic and polycyclic rings such as 3- to 10-membered monocyclic rings, 5- to 12-membered bicyclic rings, 5- to 12-membered spiro bicycles, and 5- to 12-membered bridged rings. In certain embodiments, a cycloalkyl comprises three to ten carbon atoms. In other embodiments, a cycloalkyl comprises three to seven carbon atoms. In other embodiments, a cycloalkyl comprises five to seven carbon atoms. The cycloalkyl may be attached to the rest of the molecule by a single bond. Examples of monocyclic cycloalkyls include, e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. Examples of polycyclic cycloalkyls include, but are not limited to, adamantyl, spiropentane, norbornyl (e.g., bicyclo[2.2.1]heptanyl), decalinyl, 7,7 dimethyl bicyclo[2.2.1]heptanyl, bicyclo[1.1.1]pentanyl, spiropentane, and the like.

[0030] The term "cycloalkenyl" refers to a saturated ring in which each atom of the ring is carbonand there is at least one double bond between two ring carbon atoms. Cycloalkenyl may include monocyclic and polycyclic rings, such as 3- to 10-membered monocyclic rings and 4- to 12- membered bicyclic rings (e.g., 5- to 12-membered bridged bicyclic rings, fused 4- to 12-membered bicyclic rings, and spiro 5- to 12-membered bicyclic rings). In other embodiments, a cycloalkenyl comprises five to seven carbon atoms. The cycloalkenyl may be attached to the rest of the molecule by a single bond. Examples of monocyclic cycloalkenyls include, e.g., cyclopentenyl, cyclohexenyl, cycloheptenyl, and cyclooctenyl.

[0031] The term “halo” or, alternatively, “halogen” or “halide,” means fluoro, chloro, bromo or iodo.In some embodiments, a halo is fluoro, chloro, or bromo. In some embodiments, a halo is a fluoro or a chloro. In some embodiments, a halo is a fluoro. In some embodiments, a halo is a chloro.

[0032] The term “haloalkyl” refers to an alkyl, as defined above, that is substituted by one or morehalogens, for example, trifluoromethyl, dichloromethyl, bromomethyl, 2,2,2-trifluoroethyl,1-chloromethyl-2-fluoroethyl, and the like. In some embodiments, the alkyl part of the haloalkyl is optionally further substituted as described herein.

[0033] The term “heterocycle” as used herein refers to a saturated or unsaturated (e.g., aromatic ornonaromatic unsaturated) ring or ring system in which one or more heteroatom(s) is(are) member(s) of the ring or ring system. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. For example, heterocycles include 3- to 12-membered monocyclic rings (e.g., 3- to 10- membered monocyclic rings) and 4- to 20-membered polycyclic ring systems (e.g., 4- to 15-membered fused poly ring systems, 5- to 15-membered spiro polycyclic ring systems, and 5- to 15-membered bridgedAttorney Docket No.52600-737601 polycyclic ring systems). In some embodiments, a heterocycle may be bridged, fused, spiro, or any combination thereof. In some embodiments, a heterocycle is a bridged heterocycle. In some embodiments, a heterocycle is a fused heterocycle. In some embodiments, a heterocycle is a spiro heterocycle. In some embodiments, a heterocycle is a bridged and fused heterocycle. In some embodiments, a heterocycle is a bridged and spiro heterocycle. In some embodiments, a heterocycle is a fused and spiro heterocycle. In some embodiments, a heterocycle is a bridged, fused and spiro heterocycle. For example, heterocycles include 4- to 20-membered bicyclic ring systems (e.g., 4- to 15-membered fused bicyclic ring systems, 5- to 15-membered spiro bicyclic ring systems, and 5- to 15-membered bridged bicyclic ring systems). For example, heterocycle includes tricyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, heterocycle includes tetracyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, heterocycle includes ring systems that are both fused and bridged; ring systems that are both fused and spiro; ring systems that are both bridged and spiro; and ring systems that are both fused and bridged and are also spiro. Each ring of a polycyclic heterocycle may be selected from saturated and unsaturated (e.g., aromatic or nonaromatic unsaturated) rings. A polycyclic heterocycle includes any combination of saturated, and unsaturated (e.g., aromatic or nonaromatic unsaturated) rings, as valence permits. In an exemplary embodiment, an aromatic ring, e.g., pyridyl or phenyl, may be fused to a saturated or unsaturated ring, e.g., cyclohexane, cyclopentane, morpholine, piperidine or cyclohexene, in a heterocycle, as long as at least one atom in the resulting fused ring system is a heteroatom. A polycyclic heterocycle includes any combination of ring sizes such as 3-3 spiro, 4-5 fused ring systems, 5-5 fused ring systems, 5-6 fused ring systems, 6-6 fused ring systems, 5-7 fused ring systems, 6-7 fused ring systems, 5-8 fused ring systems, and 6-8 fused ring systems. A bicyclic heterocycle further includes spiro bicyclic rings, e.g., 5 to 12-membered spiro bicycles, such as 2-oxa-6-azaspiro[3.3]heptane. In some embodiments, a heterocycle comprises multiple heteroatoms. In some embodiments, a heterocycle comprises an atom selected from nitrogen, oxygen, and sulfur. In some embodiments, a heterocycle comprises multiple atoms selected from nitrogen, oxygen, and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen, oxygen, and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen and oxygen. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from oxygen and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen. In some embodiments, a heterocycle comprises one or more atom(s) selected from oxygen. In some embodiments, a heterocycle comprises one or more atom(s) selected from sulfur. In some embodiments, aAttorney Docket No.52600-737601 heterocycle does not comprise Boron in the ring. In some embodiments, a heterocycle does not comprise Phosphorus in the ring. In some embodiments, a heterocycle does not comprise Sulfur in the ring. In some embodiments, a heterocycle does not comprise Oxygen in the ring. In some embodiments, a heterocycle does not comprise Nitrogen in the ring. In some embodiments, a heterocycle comprises only heteroatoms selected from nitrogen, oxygen, and sulfur in the ring, and the heterocycle comprises no other heteroatoms in the ring. Nonlimiting examples of heterocycles include pyridine, pyrrole, indole, carbazole, piperidine, oxazole, morpholine, thiophene, benzothiophene, furan, tetrahydrofuran, and pyran. Nonlimiting examples of heterocycles include azepinyl, acridinyl, benzimidazolyl, benzindolyl, 1,3-benzodioxolyl, benzofuranyl, benzoxazolyl, benzo[d]thiazolyl, benzothiadiazolyl, benzo[b][1,4]dioxepinyl, benzo[b][1,4]oxazinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodioxolyl, benzodioxinyl, benzopyranyl, benzopyranonyl, benzofuranyl, benzofuranonyl, benzothienyl (benzothiophenyl), benzothieno[3,2-d]pyrimidinyl, benzotriazolyl, benzo[4,6]imidazo[1,2-a]pyridinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl, 6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5,6-dihydrobenzo[h]cinnolinyl, 6,7-dihydro-5H- benzo[6,7]cyclohepta[1,2-c]pyridazinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furanonyl, furo[3,2-c]pyridinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridazinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridinyl, isothiazolyl, imidazolyl, indazolyl, indolyl, indazolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolyl, indolizinyl, isoxazolyl, 5,8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthyridinyl, 1,6-naphthyridinonyl, oxadiazolyl, 2-oxoazepinyl, oxazolyl, oxiranyl, 5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazolinyl, 1-phenyl-1H-pyrrolyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d]pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl, 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinyl, 6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,3-c]pyridinyl, and thiophenyl (e.g., thienyl).

[0034] In some embodiments, a heterocycle is attached to the molecule by a carbon atom. In someembodiments, the heterocycle is attached to the molecule by a nitrogen atom.Attorney Docket No.52600-737601

[0035] In some embodiments, a heterocycle comprises a moiety selected from a heteroaryl, aheterocycloalkyl, and a heterocycloalkenyl. In some embodiments, the heterocycle is a heteroaryl. In some embodiments, the heterocycle is a heterocycloalkyl. In some embodiments, the heterocycle is a heterocycloalkenyl.

[0036] In some embodiments, a heterocycle comprises an atom selected from nitrogen and oxygen.In some embodiments, a heterocycle comprises an atom selected from nitrogen and sulfur. In some embodiments, a heterocycle comprises an atom selected from oxygen and sulfur. In some embodiments, a heterocycle comprises an atom selected from nitrogen. In some embodiments, a heterocycle comprises an atom selected from oxygen. In some embodiments, a heterocycle comprises an atom selected from sulfur.

[0037] In some embodiments, a heterocycle comprises 1 to 8 heteroatoms. In some embodiments,the heterocycle comprises 1 to 5 heteroatoms. In some embodiments, the heterocycle comprises 1 to 3 heteroatoms. In some embodiments, the heterocycle comprises 1 to 2 heteroatoms. In some embodiments, the heterocycle comprises 1 heteroatom. In some embodiments, the heterocycle comprises 2 heteroatoms. In some embodiments, the heterocycle comprises 3 heteroatoms. In some embodiments, the heterocycle comprises 4 heteroatoms. In some embodiments, the heterocycle comprises 5 heteroatoms. In some embodiments, the heterocycle comprises 6 heteroatoms.

[0038] In some embodiments, a heterocycle comprises a 3-memberd ring, 4-membered ring, 5-membered ring, 6-membered ring, 7-membered ring, 8-membered ring, 9-membered ring, 10- membered ring, 11-membered ring, 12-membered ring, 13-membered ring, 14-membered ring, or 15-20 membered ring. In some embodiments, a heterocycle is 3- to 10-membered. In some embodiments, a heterocycle is 3- to 6-membered. In some embodiments, a heterocycle is 5- to 6- membered. In some embodiments, a heterocycle is 9- to 10-membered. In some embodiments, a heterocycle is 9- to 11-membered. In some embodiments, a heterocycle is 9- to 15-membered.

[0039] In some embodiments, the heterocycle is monosubstituted, disubstituted, trisubstituted,tetrasubstituted, or pentasubstituted (e.g., with further substituents in addition to the point of attachment). In some embodiments, the total number of substituents (e.g., atoms other than hydrogen) on the heterocycle (e.g., bonded to the ring of the heterocycle) is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more.

[0040] In some embodiments, in the molecule or moiety (e.g., in a heterocycle), one or morenitrogen atoms, if present, can be optionally quaternized. In some embodiments, the heterocycle substituent is positively charged. some embodiments, the heterocycle moiety is neutral. In some embodiments, the heterocycle substituent is zwitterionic. Alternatively, or in addition, in some embodiments, the heterocycle substituent is not charged. In some embodiments, the heterocycleAttorney Docket No.52600-737601 substituent bears no charges. In some embodiments, the heterocycle substituent bears no net charge. In some embodiments, no atoms within the heterocycle substituent bear any net charge. In some embodiments, the heterocycle substituent bears no net charge and is not zwitterionic.The term "heteroaryl" refers to a moiety derived from an aromatic monocyclic or aromatic polycyclic ring system, in which one or more heteroatom(s) is(are) member(s) of the ring system, and the ring system comprises at least one cyclic, delocalized (4n+2) π-electronic system, wherein n is an integer greater than or equal to 0, in accordance with Hückel theory. In some embodiments, one or more heteroatom(s) is(are) member(s) of the ring system comprising the cyclic, delocalized (4n+2) π- electronic system (e.g., the ring with aromaticity). Exemplary heteroatoms include N, O, Si, P, B, and S atoms. In some embodiments, a heteroaryl comprises an aromatic ring, in which one or more heteroatom(s) is(are) member(s) of the ring system, to which one or more nonaromatic rings, each of which may or may not comprise one or more heteroatom(s), may be fused. In some embodiments, a heteroaryl includes one or more heteroatoms selected from nitrogen, oxygen, and sulfur. In some embodiments, a heteroaryl includes multiple heteroatoms selected from nitrogen, oxygen, and sulfur. In certain embodiments, “heteroaryl” includes rings and ring systems comprising 3 to 20 atoms. In some embodiments, “heteroaryl” includes rings and ring systems that comprise two to seventeen carbon atoms and from one to six heteroatoms selected from nitrogen, oxygen and sulfur. As used herein, the heteroaryl moiety is a monocyclic or polycyclic (e.g., bicyclic, tricyclic or tetracyclic) ring system, wherein at least one of the rings in the ring system is aromatic, e.g., it contains a cyclic, delocalized (4n+2) π-electron system in accordance with the Hückel theory. Heteroaryl includes fused, bridged, and spiro ring systems. The heteroatom(s) in the heteroaryl moiety is(are) optionally oxidized. One or more nitrogen atom(s), if present, is(are) optionally quaternized. The heteroaryl is attached to the rest of the molecule through any atom of the ring(s). Examples of heteroaryls include, but are not limited to, acridinyl, benzimidazolyl, benzindolyl, 1,3-benzodioxolyl, benzofuranyl, benzoxazolyl, benzo[d]thiazolyl, benzothiadiazolyl, benzo[b][1,4]dioxepinyl, benzo[b][1,4]oxazinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodioxolyl, benzodioxinyl, benzopyranyl, benzopyranonyl, benzofuranyl, benzofuranonyl, benzothienyl (benzothiophenyl), benzothieno[3,2-d]pyrimidinyl, benzotriazolyl, benzo[4,6]imidazo[1,2-a]pyridinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl, 6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5,6-dihydrobenzo[h]cinnolinyl, 6,7-dihydro-5H- benzo[6,7]cyclohepta[1,2-c]pyridazinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furo[3,2-c]pyridinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridazinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridinyl, isothiazolyl, imidazolyl, indazolyl, indolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolyl,Attorney Docket No.52600-737601 indolizinyl, isoxazolyl, 5,8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthyridinyl, 1,6-naphthyridinonyl, oxadiazolyl, oxazolyl, 5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazolinyl, 1-phenyl-1H-pyrrolyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d]pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl, 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinyl, 6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,3-c]pyridinyl, and thiophenyl (e.g., thienyl). In some embodiments, further examples of “heteroaryl” include 5,6,7,8- tetrahydroquinoline; 1,2,3,4-tetrahydro-1,8-naphthyridine; 6,7-dihydro-5H-cyclopenta[b]pyridine; 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine; 4,5,6,7-tetrahydrobenzofuran; 4,5,6,7-tetrahydrofuro[2,3- b]pyridine; 5,6-dihydro-4H-cyclopenta[b]furan; 4,5-dihydrothieno[2,3-b]furan. In some embodiments, the heteroaryl substituent is positively or negatively charged. In some embodiments, the heteroaryl substituent is neutral. In some embodiments, the heteroaryl substituent is zwitterionic; alternatively, or in addition, in some embodiments, the heteroaryl substituent is not charged. In some embodiments, the heteroaryl substituent bears no charges. In some embodiments, the heteroaryl substituent bears no net charge. In some embodiments, the heteroaryl substituent bears no net charge and is not zwitterionic.

[0041] The term “heterocycle” comprises “heteroaryls,” “heterocycloalkenyls,” and“heterocycloalkyls.”

[0042] The term "heterocycloalkyl" refers to a moiety comprising a saturated ring (e.g., a ring withonly single bonds connecting the members of the ring), wherein the saturated ring comprises carbon atom(s) and one or more heteroatom(s) as member(s) of the saturated ring, and wherein the saturated ring may be optionally fused, bridged with, or spiro to an additional ring, wherein the additional ring may comprise only carbon atoms as members of the additional ring or wherein the additional ring may comprise one or more heteroatom(s) as member(s) of the additional ring. In some embodiments, a heterocycloalkyl may be covalently bound to one or more carbocycle(s) or heterocycle(s). Exemplary heteroatoms include N, O, Si, P, B, and S atoms. Heterocycloalkyl may include monocyclic and polycyclic rings such as 3- to 10-membered monocyclic rings, 6- to 12-membered bicyclic rings, 5- to 12-membered spiro bicycles, or 5- to 12-membered bridged rings. The heteroatoms in the heterocycloalkyl radical are optionally oxidized. One or more nitrogen atoms, if present, are optionally quaternized. The heterocycloalkyl is attached to the rest of the moleculeAttorney Docket No.52600-737601 through any atom of the heterocycloalkyl, valence permitting, such as any carbon or nitrogen atoms of the heterocycloalkyl. Examples of heterocycloalkyl radicals include, but are not limited to,dioxolanyl, thienyl[1,3]dithianyl, decahydroisoquinolyl, imidazolinyl, imidazolidinyl,isothiazolidinyl, isoxazolidinyl, morpholinyl, octahydroindolyl, octahydroisoindolyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, oxazolidinyl, piperidinyl, piperazinyl, 4-piperidonyl, pyrrolidinyl, pyrazolidinyl, quinuclidinyl, thiazolidinyl, tetrahydrofuryl, trithianyl, tetrahydropyranyl, thiomorpholinyl, thiamorpholinyl, 1-oxo-thiomorpholinyl, 2-oxa-6- azaspiro[3.3]heptane, and 1,1-dioxo-thiomorpholinyl. In some embodiments, a heterocycloalkyl comprises one heteroatom. In some embodiments, a heterocycloalkyl comprises one heteroatom selected from N, O, and S. In some embodiments, a heterocycloalkyl comprises multiple heteroatoms. In some embodiments, a heterocycloalkyl comprises multiple heteroatoms selected from N, O, and S.

[0043] The term "heterocycloalkenyl" refers to a moiety comprising an unsaturated ring (e.g., a ringwith either single bonds or double bonds connecting the members of the ring): wherein the unsaturated ring comprises carbon atoms and one or more heteroatom(s); wherein the unsaturated ring may be optionally fused, bridged with, or spiro to an additional ring, wherein the additional ring may comprise only carbon atoms as members of the additional ring or wherein the additional ring may comprise one or more heteroatom(s) as member(s) of the additional ring; and wherein there is at least one double bond between two ringcarbon atoms (e.g., carbon atoms that are members of the unsaturated ring). Heterocycloalkenyl does not include heteroaryl rings. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. Heterocycloalkenyl may include monocyclic and polycyclic rings such as 3- to 10-membered monocyclic rings, 6- to 12-membered bicyclic rings, and 5- to 12- membered bridged rings. In other embodiments, a heterocycloalkenyl comprises five to seven ring atoms. The heterocycloalkenyl may be attached to the rest of the molecule by a single bond. Examples of monocyclic cycloalkenyls include, e.g., pyrroline (dihydropyrrole), pyrazoline (dihydropyrazole), imidazoline (dihydroimidazole), triazoline (dihydrotriazole), dihydrofuran, dihydrothiophene, oxazoline (dihydrooxazole), isoxazoline (dihydroisoxazole), thiazoline (dihydrothiazole), isothiazoline (dihydroisothiazole), oxadiazoline (dihydrooxadiazole), thiadiazoline (dihydrothiadiazole), dihydropyridine, tetrahydropyridine, dihydropyridazine, tetrahydropyridazine, dihydropyrimidine, tetrahydropyrimidine, dihydropyrazine, tetrahydropyrazine, pyran, dihydropyran, thiopyran, dihydrothiopyran, dioxine, dihydrodioxine, oxazine, dihydrooxazine, thiazine, and dihydrothiazine.

[0044] A “spirocyclic” moiety (e.g., a “spiro” moiety) (e.g., a spirocyclic heterocycle, a spirocyclicheterocycloalkenyl, a spirocyclic carbocycle, a spirocyclic heterocycloalkyl, a spirocyclicAttorney Docket No.52600-737601 cycloalkenyl, or a spirocyclic cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) system wherein two rings share exactly one atom. Examples of spirocyclic moieties include, but are ,.

[0045] A spirocyclic heterocycle comprises a spirocyclic moiety that comprises at least oneheteroatom in the ring system of the spirocyclic moiety. Examples of spirocyclic heterocycles, .

[0046] A spirocyclic carbocycle comprises a spirocyclic moiety that comprises only carbon atoms inthe ring system of the spirocyclic moiety. Examples of spirocyclic carbocycles include, but are not.

[0047] A “fused” moiety (e.g., a fused heterocycle, a fused carbocycle, a fused heterocycloalkyl, or afused cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) wherein two rings share exactly two atoms. Examples of fused moieties include, but are not limited to:,Attorney Docket No.52600-737601

[0048] A “fused” heterocycle comprises a fused moiety that comprises at least one heteroatom in thering system of the fused moiety. Examples of fused heterocycles include, but are not limited to:

[0049] A “fused” carbocycle comprises a fused moiety that comprises only carbon atoms in the ringsystem of the fused moiety. Examples of fused carbocycles include, but are not limited to: ,

[0050] A “bridged” moiety (e.g., a bridged heterocycle, a bridged carbocycle, a bridgedheterocycloalkyl, a bridged heterocycloalkenyl, or a bridged cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) which comprises two or more bridgeheads, wherein in at least one combination of two bridgeheads, each bridgehead in the combination of two bridgeheads is separated from the other bridgehead in the combination of two bridgeheads by three bridges, each bridge comprising at least one atom, wherein each of the three bridges does not contain any of the same atoms as either of the other two bridges.

[0051] In some embodiments, a “bridged” moiety (e.g., a bridged heterocycle, a bridged carbocycle,a bridged heterocycloalkyl, a bridged heterocycloalkenyl, or a bridged cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) which comprises two or more bridgeheads, wherein in at least one pair of bridgeheads, each bridgehead in the pair is separated from the other bridgehead in the pair by three bridges, each bridge comprising at least one atom, wherein each of the three bridges does not contain any of the same atoms as either of the other two bridges.Attorney Docket No.52600-737601

[0052] In some embodiments, a bridgehead atom is a sp3-hybridized carbon or nitrogen atom thatforms a nexus between two or more rings. In some embodiments, a bridge comprises one or more atom(s) connecting two bridgehead atoms.

[0053] Examples of bridged moieties include, but are not limited to:(bicyclo[1.1.1]pentane),(bicyclo[2.1.1]hexane), norbornane (,, , , , , 2-oxa-5-azabicyclo[2.2.1]heptanebicyclo[3.1.1]heptane, bicyclo[2.2.2]octane, twistanespiro[bicyclo[2.2.1]heptane-7,1'-cyclopropane],cyclopropane]

[0054] A “bridged” carbocycle comprises a bridged moiety that comprises only carbon atoms in thering system of the bridged moiety. Examples of bridged carbocycles include, but are not limited to: (bicyclo[1.1.1]pentane),(bicyclo[2.1.1]hexane), norbornane (norbornene (),, bicyclo[2.2.2]octane,twistanespiro[bicyclo[2.2.1]heptane-7,1'-cyclopropane], andspiro[bicyclo[2.2.1]heptane-2,1'-cyclopropane].Attorney Docket No.52600-737601

[0055] A “bridged” heterocycle comprises a bridged moiety that comprises at least one heteroatomin the ring system of the bridged moiety. Examples of bridged heterocycles include, but are not

[0056] The term “substituted” refers to moieties having substituents replacing a hydrogen on one ormore carbon atom(s) or substitutable heteroatoms, e.g., an NH or NH2of a compound. It will be understood that “substitution” or “substituted with” includes the implicit proviso that such substitution is in accordance with permitted valence of the substituted atom and the substituent and further includes the proviso that the substitution results in a stable compound, e.g., a compound which does not rapidly undergo rearrangement, cyclization, elimination, etc. In certain embodiments, substituted refers to moieties having substituents replacing two hydrogen atoms on the same carbon atom, such as substituting the two hydrogen atoms on a single carbon atom with an oxo, imino, oxime, hydrazone, or thioxo group. As used herein, the term “substituted” is contemplated to include all permissible substituents of organic compounds. In a broad aspect, the permissible substituents include acyclic and cyclic, branched and unbranched, carbocyclic and heterocyclic, aromatic and non-aromatic substituents of organic compounds. The permissible substituents can be one or more and the same or different for appropriate organic compounds.

[0057] In some embodiments, the term “one or more substituents” may refer to one substituent, ortwo substituents, or three substituents, or four substituents, or five substituents, or six substituents, or more than six substituents. In some embodiments, the term “one or more substituents” may refer to one substituent. In some embodiments, the term “one or more substituents” may refer to two substituents. In some embodiments, the term “one or more substituents” may refer to three substituents. In some embodiments, the term “one or more substituents” may refer to four substituents. In some embodiments, the term “one or more substituents” may refer to five substituents. In some embodiments, the term “one or more substituents” may refer to more than five substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent to 10 substituents. In some embodiments, the term “one or more substituents” may refer to at least 1 substituent. In some embodiments, the term “one or more substituents” may refer to at most 10 substituents. In some embodiments, the term “one or more substituents” may refer to at most 5 substituents. In some embodiments, the term “one or more substituents” may refer to at most 2 substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent to 2 substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent to 1 substituent.1 substituent to 3 substituents, 1 substituent to 4 substituents, 1 substituent to 5 substituents, 1 substituent to 6 substituents, 1 substituent to 7 substituents, 1 substituent to 10Attorney Docket No.52600-737601 substituents, 2 substituents to 3 substituents, 2 substituents to 4 substituents, 2 substituents to 5 substituents, 2 substituents to 6 substituents, 2 substituents to 7 substituents, 2 substituents to 10 substituents, 3 substituents to 4 substituents, 3 substituents to 5 substituents, 3 substituents to 6 substituents, 3 substituents to 7 substituents, 3 substituents to 10 substituents, 4 substituents to 5 substituents, 4 substituents to 6 substituents, 4 substituents to 7 substituents, 4 substituents to 10 substituents, 5 substituents to 6 substituents, 5 substituents to 7 substituents, 5 substituents to 10 substituents, 6 substituents to 7 substituents, 6 substituents to 10 substituents, or 7 substituents to 10 substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent, 2 substituents, 3 substituents, 4 substituents, 5 substituents, 6 substituents, 7 substituents, or 10 substituents.

[0058] In some embodiments, substituents may include any substituents described herein, forexample: halogen, hydroxy, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=N-H), oximo (=N-OH), hydrazino (=N-NH2), -Rb-ORa, -Rb-OC(O)-Ra, -Rb-OC(O)-ORa, -Rb-OC(O)-N(Ra)2, - Rb-N(Ra)2, -Rb-C(O)Ra, -Rb-C(O)ORa, -Rb-C(O)N(Ra)2, -Rb-O-Rc-C(O)N(Ra)2, -Rb-N(Ra)C(O)ORa, - Rb-N(Ra)C(O)Ra, -Rb-N(Ra)S(O)tRa(where t is 1 or 2), -Rb-S(O)tRa(where t is 1 or 2), -Rb-S(O)tORa(where t is 1 or 2), and -Rb-S(O)tN(Ra)2 (where t is 1 or 2); and alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, aralkynyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, and heteroarylalkyl, any of which may be optionally substituted by alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=N- H), oximo (=N-OH), hydrazine (=N-NH2), -Rb-ORa, -Rb-OC(O)-Ra, -Rb-OC(O)-ORa, - Rb-OC(O)-N(Ra)2, -Rb-N(Ra)2, -Rb-C(O)Ra, -Rb-C(O)ORa, -Rb-C(O)N(Ra)2, -Rb-O-Rc-C(O)N(Ra)2, - Rb-N(Ra)C(O)ORa, -Rb-N(Ra)C(O)Ra, -Rb-N(Ra)S(O)tRa(where t is 1 or 2), -Rb-S(O)tRa(where t is 1 or 2), -Rb-S(O)tORa(where t is 1 or 2) and -Rb-S(O)tN(Ra)2 (where t is 1 or 2); wherein each Rais independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl, wherein each Ra, valence permitting, may be optionally substituted with alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=N-H), oximo (=N-OH), hydrazine (=N-NH2), -Rb-ORa, -Rb-OC(O)-Ra, -Rb-OC(O)-ORa, -Rb-OC(O)-N(Ra)2, - Rb-N(Ra)2, -Rb-C(O)Ra, -Rb-C(O)ORa, -Rb-C(O)N(Ra)2, -Rb-O-Rc-C(O)N(Ra)2, -Rb-N(Ra)C(O)ORa, - Rb-N(Ra)C(O)Ra, -Rb-N(Ra)S(O)tRa(where t is 1 or 2), -Rb-S(O)tRa(where t is 1 or 2), -Rb-S(O)tORa(where t is 1 or 2) and -Rb-S(O)tN(Ra)2(where t is 1 or 2); and wherein each Rbis independently selected from a direct bond or a straight or branched alkylene, alkenylene, or alkynylene chain, and each Rcis a straight or branched alkylene, alkenylene or alkynylene chain. In some embodiments substituents may include -Rb-N(Ra)C(O)N(Ra)2.Attorney Docket No.52600-737601

[0059] Double bonds to oxygen atoms, such as oxo groups, are represented herein as both “=O” and“(O)”. Double bonds to nitrogen atoms are represented as both “=NR” and “(NR)”. Double bonds to sulfur atoms are represented as both “=S” and “(S)”.

[0060] The phrases “parenteral administration” and “administered parenterally” as used hereinmeans modes of administration other than enteral and topical administration, usually by injection, and includes, without limitation, intravenous, intramuscular, intra-arterial, intrathecal, intracapsular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subcuticular, intraarticular, subcapsular, subarachnoid, intraspinal and intrasternal injection and infusion.

[0061] The phrase “pharmaceutically acceptable” is employed herein to refer to those compounds,materials, compositions, and / or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit / risk ratio.

[0062] The phrase “pharmaceutically acceptable excipient” or “pharmaceutically acceptable carrier”as used herein means a pharmaceutically acceptable material, composition or vehicle, such as a liquid or solid filler, diluent, excipient, solvent or encapsulating material. Each carrier must be “acceptable” in the sense of being compatible with the other ingredients of the formulation and not injurious to the patient. Some examples of materials which can serve as pharmaceutically acceptable carriers include: (1) sugars, such as lactose, glucose and sucrose; (2) starches, such as corn starch and potato starch; (3) cellulose, and its derivatives, such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; (4) powdered tragacanth; (5) malt; (6) gelatin; (7) talc; (8) excipients, such as cocoa butter and suppository waxes; (9) oils, such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; (10) glycols, such as propylene glycol; (11) polyols, such as glycerin, sorbitol, mannitol and polyethylene glycol; (12) esters, such as ethyl oleate and ethyl laurate; (13) agar; (14) buffering agents, such as magnesium hydroxide and aluminum hydroxide; (15) alginic acid; (16) pyrogen-free water; (17) isotonic saline; (18) Ringer's solution; (19) ethyl alcohol; (20) phosphate buffer solutions; and (21) other non-toxic compatible substances employed in pharmaceutical formulations.

[0063] The term “salt” or “pharmaceutically acceptable salt” refers to salts derived from a variety oforganic and inorganic counter ions well known in the art. Pharmaceutically acceptable acid addition salts can be formed with inorganic acids and / or organic acids. Inorganic acids from which salts can be derived include, for example, hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like. Organic acids from which salts can be derived include, for example, acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid,Attorney Docket No.52600-737601 succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, and the like. Pharmaceutically acceptable base addition salts can be formed with inorganic and / or organic bases. Inorganic bases from which salts can be derived include, for example, sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum, and the like. Organic bases from which salts can be derived include, for example, primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines, basic ion exchange resins, and the like, specifically such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine. In some embodiments, the pharmaceutically acceptable base addition salt is selected from ammonium, potassium, sodium, calcium, and magnesium salts.

[0064] As used herein, “treatment” or “treating” refers to an approach for obtaining beneficial ordesired results with respect to a disease, disorder, or medical condition including but not limited to a therapeutic benefit and / or a prophylactic benefit. A therapeutic benefit can include, for example, the eradication or amelioration of the underlying disorder being treated. Also, a therapeutic benefit can include, for example, the eradication or amelioration of one or more of the physiological symptoms associated with the underlying disorder such that an improvement is observed in the subject, notwithstanding that the subject may still be afflicted with the underlying disorder. In certain embodiments, for prophylactic benefit, the compositions are administered to a subject at risk of developing a particular disease, or to a subject reporting one or more of the physiological symptoms of a disease, even though a diagnosis of this disease may not have been made. Treatment via administration of a compound described herein does not require the involvement of a medical professional.

[0065] Chemical entities having carbon-carbon double bonds or carbon-nitrogen double bonds mayexist in Z- or E- form (or cis- or trans- form). Furthermore, some chemical entities may exist in various tautomeric forms. Unless otherwise specified, all structures described herein are intended to disclose, implicitly or explicitly, all Z-, E-,and tautomeric forms as well.

[0066] A “tautomer” refers to a molecule wherein a proton shift from one atom of a molecule toanother atom of the same molecule is possible. The compounds presented herein, in certain embodiments, exist as tautomers. In circumstances where tautomerization is possible, a chemical equilibrium of the tautomers will exist. The exact ratio of the tautomers depends on several factors, including physical state, temperature, solvent, and pH. Some examples of tautomeric equilibria include, but are not limited to:Attorney Docket No.52600-737601.

[0067] The compounds disclosed herein, in some embodiments, are used in different enrichedisotopic forms, e.g., enriched in the content of2H,3H,11C,13C and / or14C. In one particular embodiment, the compound is deuterated in at least one position. Such deuterated forms can be made by the procedure described in U.S. Patent Nos.5,846,514 and 6,334,997. As described in U.S. Patent Nos.5,846,514 and 6,334,997, deuteration can improve the metabolic stability and or efficacy of drugs, thus increasing the duration of action of drugs.

[0068] Unless otherwise stated, compounds described herein are intended to include compoundswhich differ only in the presence of one or more isotopically enriched atoms. For example, compounds having the present structures except for the replacement of one or more proton(s) by one or more deuterium(deuteria) or tritium(tritia), or combinations thereof, or except for the replacement of one or more12C atom(s) in the structure by one or more13C atom(s), one or more14C atom(s), or combinations thereof, in the structure are within the scope of the present disclosure.

[0069] The compounds of the present disclosure optionally comprise unnatural proportions of atomicisotopes at one or more atom(s) that constitute such compounds. For example, the compounds maybe labeled with one or more isotope(s), such as for example, deuterium (2H), tritium (3H), iodine-125(125I) or carbon-14 (14C).Isotopic substitution with2H,3H,11C,13C,14C,15C,12N,13N,15N,16N,17O,18O, 14F, 15F, 16F, 17F, 18F, 33S, 34S, 35S, 36S, 35Cl, 37Cl, 79Br, 81Br, and 125I are all contemplated. Allisotopic variations of the compounds of the present invention, whether radioactive or not, are encompassed within the scope of the present invention.

[0070] In certain embodiments, the compounds disclosed herein have some or all of the 1H atomsreplaced with2H atoms. The methods of synthesis for deuterium-containing compounds are known in the art and include, by way of non-limiting example only, the following synthetic methods.Attorney Docket No.52600-737601

[0071] Deuterium-substituted compounds are synthesized using various methods such as describedin: Dean, Dennis C.; Editor. Recent Advances in the Synthesis and Applications of Radiolabeled Compounds for Drug Discovery and Development. [In: Curr., Pharm. Des., 2000; 6(10)] 2000, 110 pp; George W.; Varma, Rajender S. The Synthesis of Radiolabeled Compounds via Organometallic Intermediates, Tetrahedron, 1989, 45(21), 6601-21; and Evans, E. Anthony. Synthesis of radiolabeled compounds, J. Radioanal. Chem., 1981, 64(1-2), 9-32.

[0072] Deuterated starting materials are readily available and are subjected to the synthetic methodsdescribed herein to provide for the synthesis of deuterium-containing compounds. Large numbers of deuterium-containing reagents and building blocks are available commercially from chemical vendors, such as MilliporeSigma.

[0073] Included in the present disclosure are salts, particularly pharmaceutically acceptable salts, ofthe compounds described herein. The compounds of the present disclosure that comprise one or more sufficiently acidic functional group(s), one or more sufficiently basic functional group(s), or both one or more sufficiently acidic functional group(s) and one or more sufficiently basic functional group(s) to form a salt (particularly a pharmaceutically acceptable salt), can react with any of a number of inorganic organic bases or inorganic or organic acids, to form a salt. ; combinations thereof); or combinations thereof. Alternatively, compounds that are inherently charged, such as those with a quaternary nitrogen, can form a salt with an appropriate counterion.

[0074] The compounds and salts described herein may in some cases exist as diastereomers,enantiomers, or other stereoisomeric forms. Unless otherwise specified (e.g., in tables of biological data), the structures disclosed herein are intended to include, explicitly or implicitly, disclosure of all diastereomeric (e.g., epimeric) and enantiomeric forms as well as mixtures thereof. Separation of stereoisomers may be performed by chromatography or by forming diastereomers and separating by recrystallization, or chromatography, or any combination thereof. (Jean Jacques, Andre Collet, Samuel H. Wilen, “Enantiomers, Racemates and Resolutions”, John Wiley And Sons, Inc., 1981, herein incorporated by reference for this disclosure). Stereoisomers may also be obtained by stereoselective synthesis.

[0075] In certain embodiments, the compounds or salts of the compounds may be prodrugs. Forexample, in some embodiments, a hydroxyl in the parent compound is presented as an ester or a carbonate, or carboxylic acid present in the parent compound is presented as an ester. The term “prodrug” is intended to encompass compounds which, under physiologic conditions, are converted into pharmaceutical agents of the present disclosure. One method for making a prodrug is to include one or more selected moieties which are hydrolyzed under physiologic conditions to reveal the desired molecule. In other embodiments, the prodrug is converted by an enzymatic activity of theAttorney Docket No.52600-737601 host animal such as specific target cells in the host animal. For example, esters or carbonates (e.g., esters or carbonates of alcohols or carboxylic acids and esters of phosphonic acids) may be prodrugs of the present disclosure. In some embodiments, a prodrug for an amine might rely on enzymatic activation. In some embodiments, a prodrug for an amine might rely on physiological chemical conditions for release of the drugs. In some embodiments, a prodrug for an amine may be selected from an amide, a carbonate, an N-acyloxy alkyl derivative, an N-acyloxy carbonyl derivative, a beta- aminoketone, an (oxodioxolenyl)methyl derivative, an N-Mannich base, an imine (e.g., a Schiff base), an enamine, an enaminone, an azo compound, a system capable of undergoing lactonization, a tetrahydrothiadiazine-2-thione, a redox system, or a PEG.

[0076] Prodrug forms of the herein described compounds, wherein the prodrug is metabolized invivo to produce a compound as set forth herein are included within the scope of the claims. In some cases, some of the herein-described compounds may be a prodrug for another derivative or active compound.

[0077] Prodrugs are often useful because, in some situations, they may be easier to administer thanthe parent drug. They may, for instance, be bioavailable by oral administration whereas the parent is not. Prodrugs may help enhance the cell permeability of a compound relative to the parent drug. The prodrug may also have improved solubility in pharmaceutical compositions over the parent drug. Prodrugs may be designed as reversible drug derivatives, for use as modifiers to enhance drug transport to site-specific tissues or to increase drug residence inside of a cell.

[0078] In some embodiments, the design of a prodrug increases the lipophilicity of thepharmaceutical agent. In some embodiments, the design of a prodrug increases the effective watersolubility. See, e.g., Fedorak et al., Am. J. Physiol., 269:G210-218 (1995); McLoed et al.,Gastroenterol, 106:405-413 (1994); Hochhaus et al., Biomed. Chrom., 6:283-286 (1992); J. Larsen and H. Bundgaard, Int. J. Pharmaceutics, 37, 87 (1987); J. Larsen et al., Int. J. Pharmaceutics, 47, 103 (1988); Sinkula et al., J. Pharm. Sci., 64:181-210 (1975); T. Higuchi and V. Stella, Pro-drugs as Novel Delivery Systems, Vol.14 of the A.C.S. Symposium Series; and Edward B. Roche, Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, 1987, all incorporated herein for such disclosure). According to another embodiment, the present disclosure provides methods of producing the above-defined compounds. The compounds may be synthesized using conventional techniques. Advantageously, these compounds are conveniently synthesized from readily available starting materials.

[0079] Synthetic chemistry transformations and methodologies useful in synthesizing thecompounds described herein are known in the art and include, for example, those described in R. Larock, Comprehensive Organic Transformations (1989); T. W. Greene and P. G. M.Attorney Docket No.52600-737601 Wuts, Protective Groups in Organic Synthesis, 2d. Ed. (1991); L. Fieser and M. Fieser, Fieser and Fieser’s Reagents for Organic Synthesis (1994); and L. Paquette, ed., Encyclopedia of Reagents for Organic Synthesis (1995). Compounds

[0080] The following comprises a discussion of compounds and salts thereof that may be used in themethods of the disclosure. In some embodiments, the compounds and salts are described in Formula (I), (I-A). (II), (III), (III-A), (IV), (V), (V-A), (VI), or (VII).

[0081] In an aspect, provided herein is a compound represented by Formula (I-A):salt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(- O-); wherein no more than three of X1, X2, X3, and X4are C(H); R1a, R1b, R1c, and R1d, are each independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a; C1-6 alkyl, C2-6 alkenyl, andC2-6 alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a,-C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a; RBis selected from: C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -Attorney Docket No.52600-737601N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3,and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from halogen,-OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; RCis selected from: hydrogen; -CN, -C(O)R10c, -C(O)N(R10c)2, -C(O)OR10c; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionallysubstituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -OC(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -S(O)R10c, -S(O)2R10c, -NO2, =S, =N(R10c), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9c; or RZtogether with RCform a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independentlyselected from R9c; RZ is selected from: hydrogen; -CN, -C(O)R10z, -C(O)N(R10z)2, and -C(O)OR10z;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from deuterium, halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -OC(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -S(O)R10z, -S(O)2R10z, -NO2, =S, =N(R10z), -N3, -CN, C3-10 carbocycle and 3- to10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle isAttorney Docket No.52600-737601 optionally substituted with one or more substituents independently selected from R9z; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9z; or RCtogether with RZform a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; R5is selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d,-C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from:hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or moreAttorney Docket No.52600-737601 substituents independently selected from R9e; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R7is selected from: hydrogen; -C(O)R10f, -C(O)N(R10f)2, -C(O)OR10f, -S(O)R10f, and -S(O)2R10f; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -C(O)OR10f, -OC(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S,=N(R10f), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9f; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9f; R8is selected from: hydrogen; -C(O)R10g, - C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9aisAttorney Docket No.52600-737601independently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; C1-3 alkyl, C2-3 alkenyl,and C2-3alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; and C3-10 carbocycle and 3- to 10-memberedheterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; each R9b is independently selected from:hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, andC2-6 alkynyl; each R9cis independently selected from: halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3,and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3,and -CN; each R9zis independently selected from: halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -Attorney Docket No.52600-737601C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3,and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3,and -CN; each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; each R9fis independently selected from: halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -Attorney Docket No.52600-737601N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and each R10a, R10b, R10c, R10z, R10d, R10e, R10f, and R10gis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O- C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl; wherein when R1ais -Cl; then RBis selected from: C3-9 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from:halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, whereineach C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituentsAttorney Docket No.52600-737601independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9b; and C10carbocycle substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle,wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b.

[0082] In an aspect, provided herein is a compound of Formula (I):salt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(-Attorney Docket No.52600-737601 O-); wherein no more than three of X1, X2, X3, and X4are C(H); R1a, R1b, R1c, and R1d, are each independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a; C1-6 alkyl, C2-6 alkenyl, andC2-6 alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a,-C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a; RBis selected from: C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3,and -CN; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from halogen,-OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; RCis selected from: hydrogen; -CN, -C(O)R10c, -C(O)N(R10c)2, -C(O)OR10c; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionallyAttorney Docket No.52600-737601 substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -C(O)OR10c, -OC(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S,=N(R10c), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9c; or RZtogether with RCform a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; RZis selected from:hydrogen; -CN, -C(O)R10z, -C(O)N(R10z)2, and -C(O)OR10z; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl,each of which is optionally substituted with one or more substituents independently selected fromdeuterium, halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -C(O)OR10z, -OC(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9z; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9z; R5is selectedfrom: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10Attorney Docket No.52600-737601 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from:hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R7is selected from: hydrogen; -C(O)R10f, -C(O)N(R10f)2, -C(O)OR10f, -S(O)R10f, and -S(O)2R10f; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -C(O)OR10f, -OC(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S,=N(R10f), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9f; and C3-10carbocycle and 3- to 10-memberedAttorney Docket No.52600-737601 heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9f; R8is selected from: hydrogen; -C(O)R10g, - C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9aisindependently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; C1-3 alkyl, C2-3 alkenyl,and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; and C3-10 carbocycle and 3- to 10-memberedheterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; each R9b is independently selected from:hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -Attorney Docket No.52600-737601N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, andC2-6alkynyl; each R9cis independently selected from: halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3,and -CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3,and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3,and -CN; each R9zis independently selected from: halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3,and -CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3,and -CN; each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -Attorney Docket No.52600-737601N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; each R9fis independently selected from: halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,Attorney Docket No.52600-737601 and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and each R10a, R10b, R10c, R10z, R10d, R10e, R10f, and R10gis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O- C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl; wherein when R1ais -Cl; then RBis selected from: C3-9 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from:halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, whereineach C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; and C10 carbocycle substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independentlyAttorney Docket No.52600-737601selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle,wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9b.

[0083] In one aspect, disclosed herein is a compound of Formula (I-A) that is represented byFormulasalt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); wherein no more than three of X1, X2, X3, and X4are C(H); R1a, R1b, R1c, and R1d, are each independently selected from: hydrogen; halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), - O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, - CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, - S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2, C1-6 haloalkyl, and C1-6 alkyl; RCis selected from: hydrogen; R5and R6are each independently selected from: hydrogen; halogen; and C1-6 alkyl, halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2;; or RZtogether with RCform a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- memberedAttorney Docket No.52600-737601 heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9c; RZis selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2, C3-10 carbocycle and 3- to10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -NO2, - CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2, and C1-6 alkyl;; or RC together with RZ form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; R5is selected from: halogen, -OR10d,-SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3,and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or moreAttorney Docket No.52600-737601 substituents independently selected from R9e; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R5together with R6form a C3-10carbocycle or 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2, and C1-6 alkyl; R7 is selected from:hydrogen; R8is selected from: hydrogen; and R9bA, R9bB, R9bC, R9bD, and R9bEare each independently selected from: hydrogen; halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, - S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2.

[0084] In an aspect, provided herein is a compound of Formula (II):salt thereof, wherein: Y0is selected from C, C(R9bF), and N; Y1is selected from C(R9bA), C(R9bA)2, N, N+(-O-), N(RbA), O, S, S(O), and S(O)2; Y2is selected from C(R9bB), C(R9bB)2, N, N+(-O-), N(RbB), O, S, S(O), and S(O)2; Y3is selected from C(R9bC), C(R9bC)2, N, N+(-O-), N(R9bC), O, S, S(O), and S(O)2; Y4is selected from C(R9bD), C(R9bD)2, N, N+(-O-), N(R9bD), O, S, S(O), and S(O)2; Y5is selected from C(R9bE), C(R9bE)2, N, N+(-O-), N(R9bE), O, S, S(O), and S(O)2; wherein no more than three of Y41, Y42, Y43, Y44, and Y45are N, N+(–O-), O, S, S(O), or S(O)2; wherein no more than four of Y41, Y42, Y43, Y44, and Y45are C(H);each is independently selected from a single bond and a double bond; RC is selected from:hydrogen; -CN, -C(O)R10c, -C(O)N(R10c)2, -C(O)OR10c; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, eachof which is optionally substituted with one or more substituents independently selected fromhalogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -C(O)OR10c, -Attorney Docket No.52600-737601OC(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9c; or RZtogether with RCform a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9c; RZis selected from: -CN, -C(O)R10z, -C(O)N(R10z)2, and -C(O)OR10z; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each ofwhich is optionally substituted with one or more substituents independently selected from deuterium,halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -C(O)OR10z, -OC(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9z; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9z; R5is selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d,-C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2,-N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyAttorney Docket No.52600-737601selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from:hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R7is selected from: hydrogen; -C(O)R10f, -C(O)N(R10f)2, -C(O)OR10f, -S(O)R10f, and -S(O)2R10f; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -C(O)OR10f, -OC(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S,=N(R10f), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9f; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -Attorney Docket No.52600-737601S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9f; R8is selected from: hydrogen; -C(O)R10g, - C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9bA, R9bB, R9bD, R9bE, and R9bFis independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b; C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; R9bCis selected from: hydrogen; halogen, -NO2, -N3, -CN, -O(C2-6 alkyl), -O(C1-6 haloalkyl), -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b; C1 alkyl, C3-6 alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle andAttorney Docket No.52600-737601 3- to 10-membered heterocycle; C2alkyl substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl; wherein when: (i) R5is ethyl, and (ii) R6is -H; then: R9bCis further selected from -OCH3; each R9cis independently selected from:halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each ofwhich is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S,=N(R10c), -N3, and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S,=N(R10c), -N3, and -CN; each R9zis independently selected from: halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3,and -CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3,and -CN; each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,Attorney Docket No.52600-737601 and -CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; each R9fis independently selected from: halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; and each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one orAttorney Docket No.52600-737601 more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and each R10b, R10c, R10z, R10d, R10e, R10f, and R10gis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O- C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl.

[0085] In an aspect, provided herein is a compound of Formula (II-AA):salt thereof, wherein: Y0is selected from C, C(R9bF), and N; Y1is selected from C(R9bA), C(R9bA)2, N, N+(-O-), N(RbA), O, S, S(O), and S(O)2; Y2is selected from C(R9bB), C(R9bB)2, N, N+(-O-), N(RbB), O, S, S(O), and S(O)2; Y3is selected from C(R9bC), C(R9bC)2, N, N+(-O-), N(R9bC), O, S, S(O), and S(O)2; Y4is selected from C(R9bD), C(R9bD)2, N, N+(-O-), N(R9bD), O, S, S(O), and S(O)2; Y5is selected from C(R9bE), C(R9bE)2, N, N+(-O-), N(R9bE), O, S, S(O), and S(O)2; wherein no more than three of Y1, Y2, Y3, Y4, and Y5are N, N+(–O-), O, S, S(O), or S(O)2; wherein no more than four of Y1, Y2, Y3, Y4, and Y5are C(H); wherein the ring formed by Y0, Y1, Y2, Y3, Y4, and Y5is a C6cycloalkyl, C6cycloalkenyl, C6aryl, 6-membered heterocycloalkyl, 6-membered heterocycloalkenyl, or a 6-membered heteroaryl; each R9bA, R9bB, R9bD, R9bE, and R9bFis independently selected from halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2; C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, - O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with oneAttorney Docket No.52600-737601 or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; RZis selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle; RC is selected from: hydrogen;R25and R26are each independently selected from: hydrogen; halogen; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle; R5and R6are each independently selected from: hydrogen; halogen; and C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2,-NH(C1-6 alkyl), and -N(C1-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle; R7is selected from: hydrogen; and R8is selected from: hydrogen.

[0086] In an aspect, provided herein is a compound represented by Formula (III-A):salt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(- O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); wherein no more than three of X1, X2, X3, and X4are C(H); R1a, R1b, R1c, and R1d, are each independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a; C1-6 alkyl, C2-6 alkenyl, andC2-6 alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a,-C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -Attorney Docket No.52600-737601C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a; Ring A is a 5- to 17-membered bridged heterocycle optionally substituted with one or more substituents independently selected from: RA; each RAis independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3,and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from halogen,-OR10b, -SR10b, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle,wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C3-10 carbocycle, 3- to 4-membered heterocycle, and 6- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and 5-membered heterocycle, optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C2-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9b; R5is selected from: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3,and -CN; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle andAttorney Docket No.52600-737601 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10carbocycle and 3- to 10-memberedAttorney Docket No.52600-737601 heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9ais independently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3,and -CN; each R9bis independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b; C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl; each R9dis independently selectedfrom: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each ofwhich is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,Attorney Docket No.52600-737601 =N(R10d), -N3, and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, and -CN; each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and each R10a, R10b, R10d, R10e, and R10gis independently selected from: hydrogen; C1-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, C3-10carbocycle, 3- to 10-membered heterocycle, and C1-6haloalkyl.Attorney Docket No.52600-737601

[0087] In an aspect, provided herein is a compound represented by Formula (III-AA):salt thereof, wherein X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(- O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N; each R1a, R1b, R1c, and R1dis independently selected from: hydrogen; halogen, -NO2, -CN, -OH, - O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2; C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, - NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and - N(C1-6alkyl)2, C3-10carbocycle and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, - S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2, C1-6haloalkyl, and C1-6alkyl; R5and R6are each independently selected from: hydrogen, halogen, and -CN; C1-6alkyl, optionally substituted at each occurrence with one or more substituents independently selected from halogen, -NO2, -CN, - OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, - O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2, C1-6 haloalkyl, and C1-6alkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -NO2, - CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; and C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, - NH(C1-6 alkyl), and -N(C1-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, optionally substituted with one or more substituents independently selected from C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2; and C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6Attorney Docket No.52600-737601 haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2, C3-10carbocycle and 3- to 10-membered heterocycle; and R8is selected from: hydrogen.

[0088] In an aspect, provided herein is a compound of Formula (III):salt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); R1a, R1b, R1c, and R1d, are each independently selected from: hydrogen; halogen, -NO2, -N3,-CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a; C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9a; Ring A is a 5- to 17-membered bridged heterocycle optionally substituted with one or more substituents independently selected from: RA; each RAis independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3,and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from halogen,-OR10b, -SR10b, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle,Attorney Docket No.52600-737601 wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C3-10 carbocycle, 3- to 4-membered heterocycle, and 6- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and 5-membered heterocycle, optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C2-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9b; R5is selected from: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3,and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6Attorney Docket No.52600-737601 alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9ais independently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3,and -CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3,and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionallyAttorney Docket No.52600-737601 substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3,and -CN; each R9bis independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b; C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl; each R9dis independently selectedfrom: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each ofwhich is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, and -CN; each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -Attorney Docket No.52600-737601N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and each R10a, R10b, R10d, R10e, and R10gis independently selected from: hydrogen; C1-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, 3- to 10-membered heterocycle, and C1-6haloalkyl; wherein when one RAis -CH3, then each additional RAis independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, and -CN; C1 alkyl substituted with one or more substituents independently selectedfrom halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle,wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C2-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -Attorney Docket No.52600-737601 CN, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; wherein when Ring A is an 11-membered bridged heterocycloalkyl comprising only one nitrogen atom as a member of the ring; then Ring A is substituted with one or more substituents independently selected from RA; and wherein when Ring A is an 8-membered bridged heterocycloalkyl comprising only two nitrogen atoms as members of the ring; then Ring A is substituted with one or more substituents independently selected from RA.

[0089] In an aspect, provided herein is a compound of Formula (IV):salt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); wherein no more than three of X1, X2, X3, and X4are C(H); R1ais selected from: hydrogen;halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and-S(O)2R10a; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -Attorney Docket No.52600-737601 CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9a; R1bis selectedfrom: hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S,=N(R10a), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a; R1cis selected from: hydrogen; fluoro, bromo, iodo, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a; C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9a; R1dis selected from: hydrogen; halogen, -NO2, -N3, -CN, -OH, -O(C4-6 alkyl), -O(C1-6 haloalkyl), -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a; C1-6 alkyl, C2-6 alkenyl, andAttorney Docket No.52600-737601 C2-6alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9a; Ring B is a 4- to 16-membered fused heterocycle optionally substituted with one or more substituents independently selected from: RA; each RAis independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3,and -CN; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from halogen,-OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected fromhalogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle,and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and R5is selected from: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3,and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -Attorney Docket No.52600-737601C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10Attorney Docket No.52600-737601 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9ais independently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3,and -CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3,and -CN; each R9bis independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b; C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; each R9dis independently selectedfrom: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each ofwhich is optionally substituted with one or more substituents independently selected from halogen, -Attorney Docket No.52600-737601OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, and -CN; each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and each R10a, R10b, R10d, R10e, and R10gis independently selected from: hydrogen; C1-6 alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -Attorney Docket No.52600-737601 NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl; wherein when X4is N; then: R8is selected from -H.

[0090] In an aspect, provided herein is a compound of Formula (IV-AA):salt thereof, wherein: R5and R6are each independently selected from: hydrogen, halogen, and -CN; C1-6alkyl, optionally substituted at each occurrence with one or more substituents independently selected from halogen, -NO2, -CN, -OH, - O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2, C1-6 haloalkyl, and C1-6 alkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -NO2, -CN, -OH, - O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and - N(C1-6alkyl)2, C3-10carbocycle and 3- to 10-membered heterocycle; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, - S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2, C3-10carbocycle and 3- to 10-membered heterocycle; and R8is selected from: hydrogen.Attorney Docket No.52600-737601

[0091] In an aspect, provided herein is a compound represented by Formula (V-A):salt thereof, wherein: Ring B is selected from: 9- to 16-membered fused heteroaryl and 6- to 16-membered fused heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from: RA; each RAisindependently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b;and R5 is selected from: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN; C1-3 alkyl substituted with one ormore substituents independently selected from halogen, -OR10d, -SH, -S(C2-6alkyl), -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; C4-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d,Attorney Docket No.52600-737601-SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from:hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN; C1-3 alkyl substituted with one ormore substituents independently selected from halogen, -OR10e, -SH, -S(C2-6alkyl), -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S,=N(R10e), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; C4-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e,-SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S,=N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle orAttorney Docket No.52600-737601 C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9e; R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9bis independently selected from: hydrogen; halogen, -NO2,-N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b,and -S(O)2R10b; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b,-C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2,-N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl; each R9dis independently selectedfrom: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each ofwhich is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -Attorney Docket No.52600-737601SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, and -CN; each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and each R10b, R10d, R10e, R10f, and R10gis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl; wherein when: (i) R5is -H, and (ii) R6is -H; then: (i) Ring B is a 9- to 16-membered fused heteroaryl or 6- to 16-membered heterocycloalkyl substituted with one or more substituents independently selectedAttorney Docket No.52600-737601 from: RA; (ii) each RAis independently selected from: fluoro, wherein: when Ring B is substituted with one fluoro group, then ring B is further substituted with one or more additional substituents independently selected from RA; and when Ring B is substituted with two fluoro groups, then ring B is a 4- to 8-membered fused heterocycle or a 10-16-membered heterocycle, each of which is optionally one or more substituents independently selected from: RA; bromo, iodo, -O(C3-6 alkyl), - O(CHF2), -O(CH2F), -O(C2-6 haloalkyl), -SR10b, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -OC(O)R10b, -NO2, =N(R10b), -N3, and -CN; C1 alkyl, wherein: no more than one RAis C1 alkyl; and when Ring B is substituted with one C1 alkyl, then ring B is further substituted with one or more additional substituents independently selected from RA, and said one or more additional substituents on Ring B does not comprise a C1alkyl; C1-2alkyl substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =S, =N(R10b), -N3, -CN,C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C2 alkyl, n-propyl, C4-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle,wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9b; and (iii) R8is selected from: hydrogen; C1-2 alkyl substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g,-C(O)N(R10g)2, , -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -Attorney Docket No.52600-737601C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g.

[0092] In an aspect, provided herein is a compound of Formula (V):salt thereof, wherein: Ring B is a 4- to 16-membered fused heterocycle optionally substituted with one or more substituents independently selected from: RA; each RAis independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN; C1-6 alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b;and R5 is selected from: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -Attorney Docket No.52600-737601 N(R10d)C(O)R10d,-C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN; C2-3 alkyl substituted with one ormore substituents independently selected from halogen, -OR10d, -SH, -S(C2-6 alkyl), -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; C1 alkyl, C4-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected fromhalogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from:hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e,-C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN; C2-3 alkyl substituted with one ormore substituents independently selected from halogen, -OR10e, -SH, -S(C2-6 alkyl), -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S,=N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; C1alkyl, C4-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected fromhalogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -Attorney Docket No.52600-737601 NO2, =O, =S, =N(R10e), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9e; R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9bis independently selected from: hydrogen; halogen, -NO2,-N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b,and -S(O)2R10b; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b,-C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2,-N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,Attorney Docket No.52600-737601 =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; each R9dis independently selectedfrom: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each ofwhich is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, and -CN; each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; each R9fis independently selected from: halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; and each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -Attorney Docket No.52600-737601C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and each R10b, R10d, R10e, R10f, and R10gis independently selected from: hydrogen; C1-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl wherein when: (i) R5is -H, and (ii) R6is -H; then: (i) each RAis independently selected from: fluoro, chloro, bromo, iodo, -OH, -O(C1-6alkyl), -O(CHF2), -O(C2-6haloalkyl), -SR10b, -N(C1-6alkyl)2, -NH(C1-6alkyl), -C(O)R10b, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -OC(O)R10b, -NO2, =N(R10b), -N3, and -CN; C1 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =S, =N(R10b), -N3, -CN,C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C2-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from halogen,-OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =S,=N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C3-5carbocycle, C7-10carbocycle, and 3- to 10-Attorney Docket No.52600-737601 membered heterocycle, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, andC2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; and C6 carbocycle substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9b; (ii) R8is selected from: hydrogen; C1-2 alkyl substituted with one or more substituents independently selectedfrom halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, =O, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-6alkyl, optionally substituted with one or more substituents independently selected fromhalogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9g; (iii) when Ring B is substituted with one fluoro, or when Ring B is substituted with two fluoro; then: Ring B is a *6-6 benzo-fused heterocycle, optionally further substituted with one or more RAin addition to the one fluoro or the two fluoro, wherein * represents the point of attachment to Formula (V); (iv) when Ring B is substituted with one methyl, then RingAttorney Docket No.52600-737601 B is a benzo-fused heterocycle selected from:, wherein n and m are both integers, each of which is independently selected from 0, 1, 2, and 3; each RA’is independently selected from -H and RA; and each RQis independently selected from -H, -F, -CN, -OH, -O(CH3), - O(CH2CH3), and -CF3; and (v) when Ring B is a *6-6 fused heterocycle or a *5-5 fused heterocycloalkyl, or a *5-6 fused heterocycle, or a *6-5 fused heterocycloalkyl, or a *5-5-6 fused heterocycle, wherein * represents the point of attachment to Formula (V), then Ring B is substituted with one or more substituents independently selected from RA.

[0093] In an aspect, provided herein is a compound of Formula (VI):salt thereof, wherein: n is an integer selected from 0 and 1; X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); Y1is selected from C(R9bA), N, and N+(-O-); Y2is selected from C(R9bB), N, and N+(-O-); Y3is selected from C(R9bC), N, and N+(-O- ); Y4is selected from C(R9bD), N, and N+(-O-); Y5is selected from C(R9bE), N, and N+(-O-); wherein no more than three of Y1, Y2, Y3, Y4, and Y5are N or N+(-O-); R1a, R1b, R1c, and R1d, are each independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a; C1-6 alkyl, C2-6 alkenyl, andC2-6alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -Attorney Docket No.52600-737601C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a; RCis selectedfrom: hydrogen; -CN, -C(O)R10c, -C(O)N(R10c)2, -C(O)OR10c; C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -C(O)OR10c, -OC(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9c; or RZtogether with RCform a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; RZis selected from:hydrogen; -CN, -C(O)R10z, -C(O)N(R10z)2, and -C(O)OR10z; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl,each of which is optionally substituted with one or more substituents independently selected fromdeuterium, halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -C(O)OR10z, -OC(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9z; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9z; R5is selectedfrom: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d,-C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -Attorney Docket No.52600-737601N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from:hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e,-C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9e; R7is selected from: - C(O)R10f, -C(O)N(R10f)2, -C(O)OR10f, -S(O)R10f, and -S(O)2R10f; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -Attorney Docket No.52600-737601N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -C(O)OR10f, -OC(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S,=N(R10f), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9f; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9f; R8is selected from: hydrogen; -C(O)R10g, - C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1 alkyl substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C2-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-5 carbocycle, C6 cycloalkyl, C7-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9aisindependently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; C1-3 alkyl, C2-3 alkenyl,and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -Attorney Docket No.52600-737601 N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; and C3-10 carbocycle and 3- to 10-memberedheterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; R9bA, R9bB, R9bC, R9bD, and R9bE are eachindependently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b; C1-6 alkyl, C2-6 alkenyl, andC2-6alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl; each R9cis independently selectedfrom: halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each ofwhich is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S,=N(R10c), -N3, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S,=N(R10c), -N3, and -CN; each R9zis independently selected from: halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -Attorney Docket No.52600-737601N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3,and -CN; each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; each R9fis independently selected from: halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, andAttorney Docket No.52600-737601 -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; and each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and each R10a, R10b, R10c, R10z, R10d, R10e, R10f, and R10gis independently selected from: hydrogen; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O- C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl; wherein when n is 0; then: (i) R7is selected from: -C(O)R10f, -C(O)N(R10f)2, -C(O)OR10f, -S(O)R10f, and - S(O)2R10f; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, =S, =N(R10f), -N3, -CN, and C3 carbocycle, C5-10 carbocycle, 3- to 4-membered heterocycle, and 6- to 10-membered heterocycle wherein each C3carbocycle, C5-10 carbocycle, 3- to 4-membered heterocycle, and 6- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9f; and C3-10 carbocycle, 3- to 4-membered heterocycle, and 6- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2,-N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl isAttorney Docket No.52600-737601 optionally substituted with one or more substituents independently selected from R9f; (ii) R9bCis selected from: hydrogen; fluoro, chloro, iodo, -N3, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), - SR10b, -N(R10b)2, -C(O)R10b, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b; C1-6 alkyl, C2-6 alkenyl, andC2-6 alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and 3- to10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl; (iii) when R9bAis methyl or when R9bBis methyl; then R9bDis selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b; C1 alkyl substituted withone or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b,-C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2,-N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle; C2-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, andC2-6 alkynyl; and (iv) when R9bBis -O(CH3) or -F; then R9bCis selected from: hydrogen; halogen, - NO2, -N3, -CN, -OH, -O(C2-6alkyl), -O(C1-6haloalkyl), -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2,-N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -Attorney Docket No.52600-737601N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, andC2-6alkynyl; wherein when n is 1, then: (i) R8is selected from: hydrogen; -C(O)R10g, - C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-2 alkyl substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-4 carbocycle, C6 cycloalkyl, C7-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9g; (ii) when X4is -C(F)-; then R1ais selected from hydrogen; halogen, -NO2, -N3, -CN, -O(C2-6 alkyl), -O(C1-6haloalkyl), -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a; C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a,-C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10Attorney Docket No.52600-737601 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a.

[0094] In an aspect, provided herein is a compound of Formula (VII):salt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(- O-); R2is selected from C1-2 alkyl substituted with one or more substituents independently selectedfrom halogen, -OR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =S, -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C3-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =S, -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle,wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10carbocycle and 3- to 18-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; or R2together with R7form a 3- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,Attorney Docket No.52600-737601 =N(R10b), -N3, and -CN; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle,wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle,and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; R1a, R1b, R1c, and R1d, are each independently selectedfrom: hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S,=N(R10a), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a; R5is selected from: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3,and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -Attorney Docket No.52600-737601N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9e; R7is selected from: hydrogen; -C(O)R10f, -C(O)N(R10f)2, -C(O)OR10f, -S(O)R10f, and -S(O)2R10f; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -C(O)OR10f, -OC(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S,=N(R10f), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or moreAttorney Docket No.52600-737601 substituents independently selected from R9f; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein eachC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9f; R8is selected from: hydrogen; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9aisindependently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; C1-3 alkyl, C2-3 alkenyl,and C2-3alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; and C3-10 carbocycle and 3- to 10-memberedheterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; each R9b is independently selected from:hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, =O, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =S,=N(R10b), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle; and C3-10carbocycle andAttorney Docket No.52600-737601 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, andC2-6 alkynyl; each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d,-C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3,and -CN; each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3,and -CN; each R9fis independently selected from: halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionallyAttorney Docket No.52600-737601 substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and-CN; and each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3,and -CN; and each R10a, R10b, R10d, R10e, R10f, and R10gis independently selected from: hydrogen; C1- 6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl; wherein when R2together with R7form a heterocycle selected from piperazine; the piperazine formed from R2and R7is optionally substituted with one or more substituents independently selected from:halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN; C2-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each ofwhich is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN; and C3-5carbocycle, C6cycloalkyl, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,Attorney Docket No.52600-737601 =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; wherein when: (i) R2is a substituted or unsubstituted 5-membered heteroaryl, substituted or unsubstituted 6-membered heteroaryl, or substituted or unsubstituted 6-membered aryl, and (ii) R6is -H; then: (a) R5is selected from: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN; C1-3 alkyl, C5-6 alkyl, C2-6 alkenyl,and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d,-C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-4 carbocycle, C6aryl, C7-10 carbocycle, 3- to 5-membered heterocycloalkyl, 6-membered heteroaryl, and 7- to 10- membered heterocycle; wherein each C3-4 carbocycle, C7-10 carbocycle, 3- to 5-membered heterocycloalkyl, 6-membered heteroaryl, and 7- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; wherein each C6 aryl is substituted with one or more substituents substituent independently selected from: Cl, -Br, -CN, - NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -C1-6alkyl, C1-6haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle; C3-4 alkyl, substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9d; and (b) R2is optionally substituted with one or more substituents selected from:halogen, -OH, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2,-OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O,Attorney Docket No.52600-737601 =S, =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b.

[0095] In an aspect, provided herein is a compound of Formula (VII-AA):salt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); wherein no more than three of X1, X2, X3, and X4are C(H); R1a, R1b, R1c, and R1d, are each independently selected from: hydrogen, halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2; C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), - O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2, C3-10carbocycle and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6alkyl)2, C1-6haloalkyl, and C1-6alkyl; R5and R6are each independently selected from: hydrogen, halogen, and -CN; C1-6 alkyl, optionally substituted at each occurrence with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, - S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2, C1-6haloalkyl, and C1-6alkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, - O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2, C3- 10 carbocycle and 3- to 10-membered heterocycle; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -NO2, -CN, -OH, -Attorney Docket No.52600-737601 O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and - N(C1-6alkyl)2, C3-10carbocycle and 3- to 10-membered heterocycle; R2is selected from C3-10carbocycle and 3- to 18-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CH3, -F, -O(CH3), -OH, -CF3, and -Cl; C1-2 alkyl optionally substituted with one or more substituents independently selected from halogen, -O(CH3), - OH, -CF3, C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, - O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2, C1-6haloalkyl, and C1-6alkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -NO2, - CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; R7is selected from C3-10carbocycle and 3- to 18-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CH3, -F, -O(CH3), -OH, -CF3, and -Cl; C1-2 alkyl optionally substituted with one or more substituents independently selected from halogen, -O(CH3), -OH, -CF3, C3-10carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6alkyl)2, C1-6haloalkyl, and C1-6alkyl; and C3-10carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, - S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; or R2together with R7form a 3- to 20- membered heterocycle optionally substituted with one or more substituents independently selected from -CH3, -F, -O(CH3), -OH, -oxo, -CF3, and -Cl; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -O(CH3), -OH, -CF3, C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, - S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2, C1-6 haloalkyl, and C1-6 alkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; and R8is selected from: hydrogen.Attorney Docket No.52600-737601

[0096] In some embodiments, for a compound or salt of Formula (I), (I-A). (II), (III), (III-A), (IV),(V), (V-A), (VI), or (VII), the compound or salt is not a compound or salt of PCT / US24 / 21537. In some embodiments, the compound or salt is not a compound or salt for which the structure is specifically drawn in PCT / US24 / 21537. In some embodiments, the compound or salt is not a solvate of any of the compounds of List 1, or a salt of any thereof. In some embodiments, the compound or salt of Formula (I), (I-A). (II), (III), (III-A), (IV), (V), (V-A), (VI), or (VII) is not compound 1, 2, 11, 12, 5, 6, 97, 3, 4, 7, 8, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 27, 28, 29, 30, 47, 105, 106, 98, 99, 100, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 214, 3001, 3002, 3003, 3004, 3005, 3006, 3007, 3008, 3009, 3010, 3011, 3013, 3014, 3015, 59, 65, 95, 96, 141, 33, 34, 35, 36, 37, 38, 39, 40, 41, 51, 69, 72, 73, 104, 402, 403, 404, 31, 32, 42, 49, 50, 70, 71, 87, 101, 102, 501, 502, 504, 506, 507, 508, 509, 510, 511, 512, 513, 601, 602, 603, 604, 605, 606, 9, 10, 44, 48, 43, 46, 55, 57, 701, 702, 5001, 5002, 5003, 5004, 5005, 5006, 5007, 5008, 5009, 213, 215, 301, 302, 303, 136, 142, 143, 154, 155, 401, 405, 406, 407, 408, 166, 167, 169, 503, 505, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527, 528, 529, 530, 533, 534, or 703, of PCT / US24 / 21537, or a salt of any thereof. In some embodiments, for a compound or salt of Formula (I), (I-A). (II), (III), (III-A), (IV), (V), (V-A), (VI), or (VII), e.g., for a compound or salt of Formula (I), (I-A). (II), (III), (III-A), (IV), (V), (V-A), (VI), or (VII), the compound or salt is not a compound of List 1: (R)-N-(1-(5- cyanopyrimidin-2-yl)ethyl)-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N- (1-(5-cyanopyrimidin-2-yl)ethyl)-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (R)-N-(1-(5-cyanopyrimidin-2-yl)ethyl)-2-(5,6-difluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)- yl)acetamide; (S)-N-(1-(5-cyanopyrimidin-2-yl)ethyl)-2-(5,6-difluoro-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)acetamide; (R)-N-(1-(2-cyanopyrimidin-5-yl)ethyl)-2-(5,6-difluoro-2,4- dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(2-cyanopyrimidin-5-yl)ethyl)-2-(5,6- difluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; 2-(2,4-dioxo-1,4-dihydroquinazolin- 3(2H)-yl)-N-(1-(pyrimidin-4-yl)ethyl)acetamide; (R)-N-(1-(6-cyanopyridazin-3-yl)ethyl)-2-(5,6- difluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(6-cyanopyridazin-3- yl)ethyl)-2-(5,6-difluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (R)-N-(1-(5-cyano-3- fluoropyridin-2-yl)ethyl)-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N- (1-(5-cyano-3-fluoropyridin-2-yl)ethyl)-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)- yl)acetamide; (R)-N-(1-(5-cyano-3-methylpyridin-2-yl)ethyl)-2-(5,6-difluoro-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(5-cyano-3-methylpyridin-2-yl)ethyl)-2-(5,6- difluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (R)-2-(6-cyano-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)acetamide; (S)-2-(6-cyano- 2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)acetamide;Attorney Docket No.52600-737601 (R)-N-(1-(5-cyanopyridin-2-yl)ethyl)-2-(5,6-difluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)- yl)acetamide; (S)-N-(1-(5-cyanopyridin-2-yl)ethyl)-2-(5,6-difluoro-2,4-dioxo-1,4-dihydroquinazolin- 3(2H)-yl)acetamide; (R)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)-2-(5-methyl-2,4-dioxo-1,4- dihydropyrido[4,3-d]pyrimidin-3(2H)-yl)acetamide; (S)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)- 2-(5-methyl-2,4-dioxo-1,4-dihydropyrido[4,3-d]pyrimidin-3(2H)-yl)acetamide; (R)-N-(1-(5-cyano- 3-fluoropyridin-2-yl)ethyl)-2-(5,6-difluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)-2-(5,6-difluoro-2,4-dioxo-1,4-dihydroquinazolin- 3(2H)-yl)acetamide; (S)-N-((S)-1-(3,5-difluoropyridin-2-yl)ethyl)-2-(2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)-4-methylpentanamide; (R)-N-((S)-1-(3,5-difluoropyridin-2-yl)ethyl)-2- (2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-4-methylpentanamide; (S)-N-((S)-1-(5-cyano-3- fluoropyridin-2-yl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-4-methylpentanamide; (R)- N-((S)-1-(5-cyano-3-fluoropyridin-2-yl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-4- methylpentanamide; N-(1-(3,5-difluoropyridin-2-yl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin- 3(2H)-yl)acetamide; (S)-N-(1-(5-chloropyridin-2-yl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin- 3(2H)-yl)acetamide; 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(5-fluoropyridin-2- yl)ethyl)acetamide; (S)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(6-hydroxypyridin-3- yl)ethyl)acetamide; (S)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(3-fluoropyridin-4- yl)ethyl)acetamide; (R)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(3-fluoropyridin-4- yl)ethyl)acetamide; (R)-N-(1-(5-cyanopyrimidin-2-yl)ethyl)-2-(5-fluoro-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(5-cyanopyrimidin-2-yl)ethyl)-2-(5-fluoro-2,4- dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (R)-2-(5-cyano-2,4-dioxo-1,4-dihydroquinazolin- 3(2H)-yl)-N-(1-(5-cyanopyrimidin-2-yl)ethyl)acetamide; (S)-2-(5-cyano-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)-N-(1-(5-cyanopyrimidin-2-yl)ethyl)acetamide; (R)-2-(5-cyano-2,4- dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)acetamide; (S)-2- (5-cyano-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(5-cyano-3-fluoropyridin-2- yl)ethyl)acetamide; (R)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)-2-(5-fluoro-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)-2-(5-fluoro- 2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (R)-N-(1-(2-cyanopyrimidin-5-yl)ethyl)-2-(6- fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(2-cyanopyrimidin-5- yl)ethyl)-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-3-cyclopropyl-N- ((S)-1-(3,5-difluoropyridin-2-yl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)propanamide; (R)-3-cyclopropyl-N-((S)-1-(3,5-difluoropyridin-2-yl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin- 3(2H)-yl)propanamide; 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(pyrimidin-5- yl)ethyl)acetamide; (R)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)-2-(5-cyano-6-fluoro-2,4-dioxo-Attorney Docket No.52600-737601 1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)-2-(5- cyano-6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (R)-N-(1-(5-cyano-3- fluoropyridin-2-yl)ethyl)-2-(5-fluoro-6-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)-2-(5-fluoro-6-methyl-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)acetamide; (R)-N-(1-(5-cyanopyrimidin-2-yl)ethyl)-2-(6-fluoro-5- methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(5-cyanopyrimidin-2- yl)ethyl)-2-(6-fluoro-5-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (R)-N-(1-(5- cyano-3-fluoropyridin-2-yl)ethyl)-2-(6-fluoro-5-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)- yl)acetamide; (S)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)-2-(6-fluoro-5-methyl-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)acetamide; (R)-N-(1-(5-cyanopyridin-2-yl)ethyl)-2-(6-fluoro-5-methyl- 2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(5-cyanopyridin-2-yl)ethyl)-2-(6- fluoro-5-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (R)-N-(1-(5-cyano-3- fluoropyridin-2-yl)ethyl)-1-(5,6-difluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)cyclopropane-1- carboxamide; (S)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)-1-(5,6-difluoro-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)cyclopropane-1-carboxamide; (R)-1-(5-cyano-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)cyclopropane-1- carboxamide; (S)-1-(5-cyano-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(5-cyano-3- fluoropyridin-2-yl)ethyl)cyclopropane-1-carboxamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)-2-(5- hydroxy-2,4-dioxo-1,4-dihydropyrido[4,3-d]pyrimidin-3(2H)-yl)acetamide; (S)-N-(1-(2,4- difluorophenyl)ethyl)-2-(5-methoxy-2,4-dioxo-1,4-dihydropyrido[4,3-d]pyrimidin-3(2H)- yl)acetamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)-2-(2,4-dioxo-1,4-dihydropyrimido[4,5- d]pyrimidin-3(2H)-yl)acetamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)-2-(2,4-dioxo-1,4- dihydropyrimido[5,4-d]pyrimidin-3(2H)-yl)acetamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)-2-(2,4- dioxo-1,4-dihydropyrido[4,3-d]pyrimidin-3(2H)-yl)acetamide; (S)-N-((S)-1-(2,4- difluorophenyl)ethyl)-2-(5-hydroxy-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-3- phenylpropanamide; (R)-N-((S)-1-(2,4-difluorophenyl)ethyl)-2-(5-hydroxy-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)-3-phenylpropanamide; (S)-N-((S)-1-(2,4-difluorophenyl)ethyl)-2-(5- hydroxy-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)propanamide; (R)-N-((S)-1-(2,4- difluorophenyl)ethyl)-2-(5-hydroxy-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)propanamide; (R)-2- (5,6-difluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-((S)-1-(2,4- difluorophenyl)ethyl)propanamide; (S)-2-(5,6-difluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)- N-((S)-1-(2,4-difluorophenyl)ethyl)propanamide; (S)-2-(5,6-difluoro-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)-N-(1-(2,4-difluorophenyl)ethyl)acetamide; (S)-N-((S)-1-(2,4- difluorophenyl)ethyl)-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)propanamide; (R)-N-Attorney Docket No.52600-737601 ((S)-1-(2,4-difluorophenyl)ethyl)-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)- yl)propanamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)-2-(6-methyl-2,4-dioxo-1,4-dihydroquinazolin- 3(2H)-yl)acetamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)-2-(5-methoxy-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)-2-(5-hydroxy-2,4-dioxo- 1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)-2-(5-methyl-2,4- dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-2-(6-chloro-2,4-dioxo-1,4-dihydroquinazolin- 3(2H)-yl)-N-(1-(2,4-difluorophenyl)ethyl)acetamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)-2-(6- fluoro-1-(methoxymethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(2,4- difluorophenyl)ethyl)-2-(6-fluoro-1-((2-methoxyethoxy)methyl)-2,4-dioxo-1,4-dihydroquinazolin- 3(2H)-yl)acetamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)-2-(6-fluoro-1-methyl-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-((S)-1-(2,4-difluorophenyl)ethyl)-2-(2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)-4-methylpentanamide; (R)-N-((S)-1-(2,4-difluorophenyl)ethyl)-2-(2,4- dioxo-1,4-dihydroquinazolin-3(2H)-yl)-4-methylpentanamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)- 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-2-methylpropanamide; (S)-N-(1-(2,4- difluorophenyl)propyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1-(2,4- difluorophenyl)-2-methylpropyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1- (2,4-difluorophenyl)-3-methylbutyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; N-(1- (2,4-difluorophenyl)propyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; N-(1-(2,4- difluorophenyl)-2-hydroxyethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (R)-N- ((S)-1-(2,4-difluorophenyl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)propanamide; (S)-N- ((S)-1-(2,4-difluorophenyl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)propanamide; (S)-3- cyclopropyl-N-((S)-1-(2,4-difluorophenyl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)- yl)propanamide; (R)-3-cyclopropyl-N-((S)-1-(2,4-difluorophenyl)ethyl)-2-(2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)propanamide; N-((S)-1-(2,4-difluorophenyl)ethyl)-2-(2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)-3-phenylpropanamide; N-(1-(2,4-difluorophenyl)ethyl)-2-(2,4-dioxo- 1,4-dihydroquinazolin-3(2H)-yl)-N-isobutylacetamide; N-(1-(2,4-difluorophenyl)ethyl)-2-(2,4- dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-isopropylacetamide; N-((S)-1-(2,4-difluorophenyl)ethyl)- 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-2-(pyridin-3-yl)acetamide; N-((S)-1-(2,4- difluorophenyl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)butanamide; N-((S)-1-(2,4- difluorophenyl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-2-phenylacetamide; N-((S)-1- (2,4-difluorophenyl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-3-hydroxypropanamide; N- ((S)-1-(2,4-difluorophenyl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-4- methylpentanamide; N-((S)-1-(2,4-difluorophenyl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)- yl)-3-methylbutanamide; 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(thiazol-2-Attorney Docket No.52600-737601 yl)ethyl)acetamide; N-(1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin- 3(2H)-yl)acetamide; 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(1-methyl-1H-pyrazol-4- yl)ethyl)acetamide; 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(furan-2-yl)ethyl)acetamide; N-(1-cyclopentylethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; 2-(2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)-N-(1-(thiophen-2-yl)ethyl)acetamide; (R)-N-(3-cyano-6,7-dihydro-5H- cyclopenta[b]pyridin-7-yl)-2-(6-fluoro-5-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)- yl)acetamide; (S)-N-(3-cyano-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)-2-(6-fluoro-5-methyl-2,4- dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(5,7-difluoro-2,3-dihydro-1H-inden-1-yl)-2- (2,4-dioxo-1,4-dihydropyrido[4,3-d]pyrimidin-3(2H)-yl)acetamide; (S)-N-(5,7-difluoro-2,3-dihydro- 1H-inden-1-yl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; N-(5,7-difluoro-2-methyl- 1-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; N-(5,7-difluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)-2-(2,4-dioxo-1,4-dihydroquinazolin- 3(2H)-yl)acetamide; (S)-N-(6,8-difluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)acetamide; (R)-N-(6,8-difluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2- (2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(6-cyano-2,3-dihydrofuro[3,2- b]pyridin-3-yl)-2-(6-fluoro-5-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (R)-N- (6-cyano-2,3-dihydrofuro[3,2-b]pyridin-3-yl)-2-(6-fluoro-5-methyl-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)acetamide; 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(4- methylmorpholin-2-yl)ethyl)acetamide; (S)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1- (naphthalen-1-yl)ethyl)acetamide; N-(1-cyclohexylethyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)- yl)acetamide; N-(4-((1H-pyrazol-1-yl)methyl)benzyl)-2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)- yl)acetamide; 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(pyridin-2-ylmethyl)acetamide; 2- (2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(pyridin-3-ylmethyl)acetamide; 2-(2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)-N-(pyridin-4-ylmethyl)acetamide; N-(2-chlorophenethyl)-2-(2,4-dioxo- 1,4-dihydroquinazolin-3(2H)-yl)acetamide; N-(2,4-difluorobenzyl)-2-(2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)acetamide ; 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1- (pyridin-4-yl)ethyl)acetamide; 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1-(pyrazin-2- yl)ethyl)acetamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)-2-(2,4-dioxo-1,4-dihydropyrido[3,4- d]pyrimidin-3(2H)-yl)acetamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)-2-(2,4-dioxo-1,4- dihydropyrido[2,3-d]pyrimidin-3(2H)-yl)acetamide; (S)-N-(1-(2,4-difluorophenyl)ethyl)-2-(2,4- dioxo-1,4-dihydropyrido[3,2-d]pyrimidin-3(2H)-yl)acetamide; (S)-2-(5-chloro-2,4-dioxo-1,4- dihydroquinazolin-3(2H)-yl)-N-(1-(2,4-difluorophenyl)ethyl)acetamide; (S)-N-(1-(2,4- difluorophenyl)ethyl)-2-(7-methoxy-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-(1- (2,4-difluorophenyl)ethyl)-2-(7-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)-N-Attorney Docket No.52600-737601 (1-(2,4-difluorophenyl)ethyl)-2-(5-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (S)- N-(1-(2,4-difluorophenyl)ethyl)-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; (3-(2-(((S)-1-(2,4-difluorophenyl)ethyl)amino)-2-oxoethyl)-6-fluoro-2,4-dioxo-3,4- dihydroquinazolin-1(2H)-yl)methyl L-valinate; (S...

Claims

1. Attorney Docket No.52600-737601 CLAIMS WHAT IS CLAIMED IS:

1. A compound represented by Formula (I-A):or a salt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); wherein no more than three of X1, X2, X3, and X4are C(H); R1a, R1b, R1c, and R1d, are each independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a,-N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6Attorney Docket No.52600-737601 alkynyl is optionally substituted with one or more substituents independently selected from R9a; RBis selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O,=S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9b; wherein when RBis a 3- to 10-membered heterocycle; then the 3- to 10-membered heterocycle comprises one or more heteroatom(s) selected from nitrogen, oxygen, and sulfur; RCis selected from: hydrogen; -CN, -C(O)R10c, -C(O)N(R10c)2, -C(O)OR10c;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, - N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -OC(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -S(O)R10c, -S(O)2R10c, -NO2, =S, =N(R10c), -N3, -CN, C3-10carbocycle and 3- to 10-memberedAttorney Docket No.52600-737601 heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9c; or RZtogether with RCform a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; RZis selected from: hydrogen; -CN, -C(O)R10z, -C(O)N(R10z)2, and -C(O)OR10z;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from deuterium, halogen, -OR10z, - SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -OC(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -S(O)R10z, -S(O)2R10z, -NO2, =S, =N(R10z), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9z; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9z; orAttorney Docket No.52600-737601 RCtogether with RZform a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; R5is selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e,-C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, - OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -Attorney Docket No.52600-737601 N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R7is selected from: hydrogen; -C(O)R10f, -C(O)N(R10f)2, -C(O)OR10f, -S(O)R10f, and -S(O)2R10f; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -C(O)OR10f, -OC(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9f; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9f;Attorney Docket No.52600-737601 R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9ais independently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, - S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, - OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;each R9bis independently selected from: hydrogen;Attorney Docket No.52600-737601 halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, - S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl; each R9cis independently selected from: halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, - N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, - S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, - OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN;each R9zis independently selected from: halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, and -CN;Attorney Docket No.52600-737601 C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, - N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, - S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, - OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, and -CN;each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, - OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, - S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN; andAttorney Docket No.52600-737601 C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, - OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;each R9fis independently selected from: halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, - N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, - S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, - OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN;each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, - S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, - OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andeach R10a, R10b, R10c, R10z, R10d, R10e, R10f, and R10gis independently selected from:Attorney Docket No.52600-737601 hydrogen; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, - NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and C1-6haloalkyl; wherein when R1ais -Cl; then RBis selected from: C3-9 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; and C10carbocycle substituted with one or more substituents independently selected from:Attorney Docket No.52600-737601 halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b.A compound represented by Formula (I):or a salt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); wherein no more than three of X1, X2, X3, and X4are C(H); R1a, R1b, R1c, and R1d, are each independently selected from:Attorney Docket No.52600-737601 hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a; RBis selected from: C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O,=S, =N(R10b), -N3, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; andAttorney Docket No.52600-737601 C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; RCis selected from: hydrogen; -CN, -C(O)R10c, -C(O)N(R10c)2, -C(O)OR10c;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, - N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -C(O)OR10c, -OC(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9c; or RZtogether with RCform a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; RZis selected from: hydrogen; -CN, -C(O)R10z, -C(O)N(R10z)2, and -C(O)OR10z;Attorney Docket No.52600-737601 C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from deuterium, halogen, -OR10z, - SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -C(O)OR10z, -OC(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, - S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9z; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, - N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9z; R5is selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6Attorney Docket No.52600-737601 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, - OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R7is selected from: hydrogen; -C(O)R10f, -C(O)N(R10f)2, -C(O)OR10f, -S(O)R10f, and -S(O)2R10f; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -Attorney Docket No.52600-737601 N(R10f)C(O)R10f,-C(O)OR10f, -OC(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9f; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9f; R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; ach R9ais independently selected from:Attorney Docket No.52600-737601 halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, - S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, - OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;ach R9bis independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, - S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl; each R9cis independently selected from: halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN;Attorney Docket No.52600-737601 C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, - N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, - S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, - OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN;each R9zis independently selected from: halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, - N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, - S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, - OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, and -CN;each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; andAttorney Docket No.52600-737601 C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, - OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, - S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, - OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;each R9fis independently selected from: halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, - N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, - S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, - OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN;each R9gis independently selected from:Attorney Docket No.52600-737601 halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, - S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, - OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andeach R10a, R10b, R10c, R10z, R10d, R10e, R10f, and R10gis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, - NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and C1-6haloalkyl; wherein when R1ais -Cl; then RBis selected from: C3-9 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -Attorney Docket No.52600-737601 N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; and C10carbocycle substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b.Attorney Docket No.52600-7376013. The compound or salt of claim 1 or claim 2, wherein the compound is not compound: 801, 802,803, 804, 805, 806, 807, 808, 809, 810, 811, 812, 813, 814, 815, or 816, or a salt of any thereof.

4. The compound or salt of any one of claims 1 to 3, wherein X1 is selected from C(R1a), and R1a isnot chloro; X2is selected from C(R1b), and N; X3is selected from C(R1c) and N; and X4is selected from C(R1d) and N.

5. The compound or salt of any one of claims 1 to 4, wherein X1 is selected from: C(OH), N,C(OCH3), C(F), and C(H); and X2is selected from: C(H), N, and C(F)6 The compound or salt of any one of claims 1 to 5, wherein X3 is selected from: C(H) and N.7 The compound or salt of any one of claims 1 to 6, wherein X4 is selected from: C(H), N, andC(F).8 The compound or salt of any one of claims 1 to 7, wherein X4 is selected from: C(H).9 The compound or salt of any one of claims 1 to 8, wherein R1a, R1b, R1c, and R1d, are eachindependently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, and -N(R10a)2; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, =O, - CN, and C1-6alkyl.10 The compound or salt of any one of claims 1 to 9, wherein R1a, R1b, R1c, and R1d, are eachindependently selected from: hydrogen, -F, -OH, and -O(CH3).11 The compound or salt of any one of claims 1 to 10, wherein RB is selected from: C3-10 carbocycleand 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, and -CN; C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -CN, and C1-6 alkyl.Attorney Docket No.52600-73760112. The compound or salt of any one of claims 1 to 11, wherein RB is selected from: C3-10 carbocycleand 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: -F and -O(CH3).

13. The compound or salt of any one of claims 1 to 12, wherein RB is selected from:,14. The compound or salt of any one of claims 1 to 13, wherein RC is selected from: -H.

15. The compound or salt of any one of claims 1 to 14, wherein RZ is selected from: -CH3.

16. The compound or salt of any one of claims 1 to 15, wherein R6 is selected from: -H.

17. The compound or salt of any one of claims 1 to 16, wherein R5 is selected from:halogen; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, -CN, and C1-6 alkyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from halogen, - OH, and -O(CH3).

18. The compound or salt of any one of claims 1 to 17, wherein R5 is selected from:, ,Attorney Docket No.52600-73760119. The compound or salt of any one of claims 1 to 18, wherein R5 is selected from:, ,Attorney Docket No.52600-73760120. The compound or salt of any one of claims 1 to 15, wherein: R5 together with R6 form a 5- to 10-membered heterocycle or C5-10 carbocycle, wherein the 5- to 10- membered heterocycle or C5-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d.

21. The compound or salt of any one of claims 1 to 20, wherein: R7 is -H.

22. The compound or salt of any one of claims 1 to 21, wherein when R1a is -Cl; then RB is selectedfrom: C3-6carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, - NO2, =O, -CN, -CH3, and -CF3.

23. The compound or salt of any one of claims 1 to 22, wherein: R8 is -H.

24. The compound or salt of claim 1, selected from a compound of Table 1, or a salt of any onethereof.

25. A compound represented by Formula (II):or a salt thereof, wherein: Y0is selected from C, C(R9bF), and N; Y1is selected from C(R9bA), C(R9bA)2, N, N+(-O-), N(RbA), O, S, S(O), and S(O)2;Attorney Docket No.52600-737601 Y2is selected from C(R9bB), C(R9bB)2, N, N+(-O-), N(RbB), O, S, S(O), and S(O)2; Y3is selected from C(R9bC), C(R9bC)2, N, N+(-O-), N(R9bC), O, S, S(O), and S(O)2; Y4is selected from C(R9bD), C(R9bD)2, N, N+(-O-), N(R9bD), O, S, S(O), and S(O)2; Y5is selected from C(R9bE), C(R9bE)2, N, N+(-O-), N(R9bE), O, S, S(O), and S(O)2; wherein no more than three of Y1, Y2, Y3, Y4, and Y5are N, N+(–O-), O, S, S(O), or S(O)2; wherein no more than four of Y1, Y2, Y3, Y4, and Y5are C(H); wherein the ring formed by Y0, Y1, Y2, Y3, Y4, and Y5is a C6cycloalkyl, C6cycloalkenyl, C6aryl, 6-membered heterocycloalkyl, 6-membered heterocycloalkenyl, or a 6-membered heteroaryl; each is independently selected from a single bond and a double bond; RCis selected from: hydrogen; -CN, -C(O)R10c, -C(O)N(R10c)2, -C(O)OR10c;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, - N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -C(O)OR10c, -OC(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9c; or RZtogether with RCform a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9c; RZis selected from: -CN, -C(O)R10z, -C(O)N(R10z)2, and -C(O)OR10z;Attorney Docket No.52600-737601 C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from deuterium, halogen, -OR10z, - SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -C(O)OR10z, -OC(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, - S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9z; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9z; R5is selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6Attorney Docket No.52600-737601 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, - OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R7is selected from: hydrogen; -C(O)R10f, -C(O)N(R10f)2, -C(O)OR10f, -S(O)R10f, and -S(O)2R10f; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -Attorney Docket No.52600-737601 N(R10f)C(O)R10f,-C(O)OR10f, -OC(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9f; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9f; R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9bA, R9bB, R9bD, R9bE, and R9bFis independently selected from: hydrogen;Attorney Docket No.52600-737601 halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, - S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl; R9bCis selected from: hydrogen; halogen, -NO2, -N3, -CN, -O(C2-6 alkyl), -O(C1-6 haloalkyl), -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b;C1alkyl, C3-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, - S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle; C2alkyl substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, - OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -Attorney Docket No.52600-737601 N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl; wherein when: (i) R5is ethyl, and (ii) R6is -H; then: R9bCis further selected from -OCH3; each R9cis independently selected from: halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, - N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, - S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, - OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN;each R9zis independently selected from: halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, - N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, - S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, - OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, and -CN;each R9dis independently selected from:Attorney Docket No.52600-737601 halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, - OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, - S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, - OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;each R9fis independently selected from: halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, - N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -Attorney Docket No.52600-737601 OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, - S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, - OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN; andeach R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, - S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, - OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andeach R10b, R10c, R10z, R10d, R10e, R10f, and R10gis independently selected from: hydrogen; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, - NH(C1-6alkyl), C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, 3- to 10- membered heterocycle, and C1-6 haloalkyl.Attorney Docket No.52600-73760126. The compound or salt of claim 25, wherein the compound is not compound: 817, 818, 819, 820,821, 822, 823, 824, 825, 826, 827, 828, 829, 830, 831, 834, 835, 836, 837, 838, or 839, or a salt of any thereof.

27. The compound or salt of claim 25 or 26, wherein Y1, Y2, Y3, Y4, and Y5 are each independentlyselected from: N, C(H), C(F), C(CN), C(OH), and C(OCH3).

28. The compound or salt of any one of claims 25 to 27, wherein RC is selected from: -H, and RZ isselected from: -CH3.

29. The compound or salt of any one of claims 25 to 28, wherein R6 is selected from: -H.

30. The compound or salt of any one of claims 25 to 29, wherein R5 is selected from:halogen; and C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -NO2, =O, -CN, and C1-6 alkyl.

31. The compound or salt of any one of claims 25 to 30, wherein R5 is selected from:.

32. The compound or salt of any one of claims 25 to 31, wherein: R5 together with R6 form a 5- to10- membered heterocycle or C5-10carbocycle, wherein the 5- to 10- membered heterocycle or C5-10carbocycle is optionally substituted with one or more substituents independently selected from R9d.

33. The compound or salt of any one of claims 25 to 32, wherein: R7 is -H, and R8 is -H.

34. The compound or salt of any one of claims 25 to 33, selected from compound: 201, 202, 203,204, and 205 or a salt of any one thereof.

35. A compound represented by Formula (III-A):Attorney Docket No.52600-737601or a salt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); wherein no more than three of X1, X2, X3, and X4are C(H); R1a, R1b, R1c, and R1d, are each independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a,-N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a;Attorney Docket No.52600-737601 Ring A is a 5- to 17-membered bridged heterocycle optionally substituted with one or more substituents independently selected from: RA; each RAis independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O,=S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C3-10 carbocycle, 3- to 4-membered heterocycle, and 6- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O,=S, =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and 5-membered heterocycle, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, - C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O,=S, =N(R10b), -N3, -CN, C2-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; R5is selected from: hydrogen;Attorney Docket No.52600-737601 halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, - OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle isAttorney Docket No.52600-737601 optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; ach R9ais independently selected from:Attorney Docket No.52600-737601 halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, - S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, - OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;ach R9bis independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, - S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl; each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;Attorney Docket No.52600-737601 C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, - OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, - S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, - OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, - S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andAttorney Docket No.52600-737601 C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, - OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andeach R10a, R10b, R10d, R10e, and R10gis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, - NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and C1-6 haloalkyl.6 A compound represented by Formula (III):or a salt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); R1a, R1b, R1c, and R1d, are each independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;Attorney Docket No.52600-737601 C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9a; Ring A is a 5- to 17-membered bridged heterocycle optionally substituted with one or more substituents independently selected from: RA; each RAis independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O,=S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C3-10carbocycle, 3- to 4-membered heterocycle, and 6- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -Attorney Docket No.52600-737601 N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O,=S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and 5-membered heterocycle, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, - C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O,=S, =N(R10b), -N3, -CN, C2-6alkyl, C1-6haloalkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9b; R5is selected from: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9d; orAttorney Docket No.52600-737601 R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e,-C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, - OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,Attorney Docket No.52600-737601 =N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9ais independently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, - S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, - OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;each R9bis independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -Attorney Docket No.52600-737601 S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl; each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, - OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, - S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -Attorney Docket No.52600-737601 N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, - OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, - S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, - OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andeach R10a, R10b, R10d, R10e, and R10gis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, - NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and C1-6haloalkyl; wherein when one RAis -CH3, then each additional RAis independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN;C1 alkyl substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -Attorney Docket No.52600-737601 OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C2-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O,=S, =N(R10b), -N3, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; wherein when Ring A is an 11-membered bridged heterocycloalkyl comprising only one nitrogen atom as a member of the ring; then Ring A is substituted with one or more substituents independently selected from RA; and wherein when Ring A is an 8-membered bridged heterocycloalkyl comprising only two nitrogen atoms as members of the ring; then Ring A is substituted with one or more substituents independently selected from RA.

37. The compound or salt of claim 35 or 36, wherein X1 is selected from: C(F), and X2 is selectedfrom: C(F).

38. The compound or salt of any one of claims 35 to 37, wherein X3 is selected from: C(H), and X4 isselected from: C(H).

39. The compound or salt of any one of claims 35 to 38, wherein each RA is independently selectedfrom: halogen, -OH, -O(CH3), -O(CF3), -SH, -SCH3, =O, -CN, -CH3, and -CF3.

40. The compound or salt of any one of claims 35 to 39, wherein R6 is selected from: -H.

41. The compound or salt of any one of claims 35 to 40, wherein R5 is selected from:Attorney Docket No.52600-737601 hydrogen; halogen; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -NO2, =O, -CN, and C1-6alkyl.

42. The compound or salt of any one of claims 35 to 39, wherein: R5 together with R6 form a 5- to10- membered heterocycle or C5-10 carbocycle, wherein the 5- to 10- membered heterocycle or C5-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d.

43. The compound or salt of any one of claims 35 to 42, wherein: R7 is -H, and R8 is -H.

44. The compound or salt of any one of claims 35 to 43, wherein Ring A is a 9 to 13-memberedbridged heterocycle optionally substituted with one or more substituents independently selected from RA.

45. The compound or salt of any one of claims 35 to 44, selected from compound: 301, 302, 303,304, 305, 306, 307, 308, Q101, and Q102, or a salt of any one thereof.

46. A compound represented by Formula (IV):or a salt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein when X4is N; then: R8is selected from -H; wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); wherein no more than three of X1, X2, X3, and X4are C(H);Attorney Docket No.52600-737601 R1ais selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a,-N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a; R1bis selected from: hydrogen; halogen, -NO2, -N3, -CN, -OH, -O(C2-6alkyl), and -O(C1-6haloalkyl), -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle isAttorney Docket No.52600-737601 optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a; R1cis selected from: hydrogen; fluoro, bromo, iodo, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a,-N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a; R1dis selected from: hydrogen;Attorney Docket No.52600-737601 halogen, -NO2, -N3, -CN, -OH, -O(C4-6alkyl), -O(C1-6haloalkyl), -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a; Ring B is a 4- to 16-membered fused heterocycle optionally substituted with one or more substituents independently selected from: RA; each RAis independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O,=S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b;Attorney Docket No.52600-737601 C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and R5is selected from: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from:Attorney Docket No.52600-737601 hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, - OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; andAttorney Docket No.52600-737601 C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9ais independently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, - S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, - OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;each R9bis independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, - S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; andAttorney Docket No.52600-737601 C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl; each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, - OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, - S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, - OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;Attorney Docket No.52600-737601 each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, - S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, - OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andeach R10a, R10b, R10d, R10e, and R10gis independently selected from: hydrogen; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, - NH(C1-6alkyl), C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, 3- to 10- membered heterocycle, and C1-6 haloalkyl.

47. The compound or salt of claim 46, wherein X1 is selected from C(R1a) and N; X2 is selected fromC(R1b) and N; X3is selected from C(R1c) and N; and X4is selected from C(R1d) and N.

48. The compound or salt of claim 46 or 47, wherein X1 is selected from: C(H), C(OH) and C(F); X2is selected from: C(H) and C(F); X3 is selected from: C(H); and X4 is selected from: C(H).

49. The compound or salt of any one of claims 46 to 48, wherein R1a, R1b, R1c, and R1d, are eachindependently selected from: hydrogen, fluoro, -CN, -OH, -O(CH3), -CH3, and -CF3.

50. The compound or salt of any one of claims 46 to 49, wherein each RA is independently selectedfrom: halogen, -OH, -O(CH3), -O(CF3), -SH, -SCH3, =O, -CN, -CH3, and -CF3.

51. The compound or salt of any one of claims 46 to 50, wherein R6 is selected from: -H.Attorney Docket No.52600-73760152. The compound or salt of any one of claims 46 to 51, wherein R5 is selected from:hydrogen; halogen; and C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -NO2, =O, -CN, and C1-6alkyl.

53. The compound or salt of any one of claims 46 to 52, wherein: R5 together with R6 form a 5- to10- membered heterocycle or C5-10 carbocycle, wherein the 5- to 10- membered heterocycle or C5-10carbocycle is optionally substituted with one or more substituents independently selected from R9d.

54. The compound or salt of any one of claims 46 to 53, wherein: R7 is -H, and R8 is -H.

55. The compound or salt of any one of claims 46 to 54, wherein: Ring B is an 8- to 12-memberedfused heterocycle optionally substituted with one or more substituents independently selected from: RA.

56. The compound or salt of any one of claims 46 to 55, selected from a compound of Table 4, or asalt of any one thereof.

57. A compound represented by Formula (V-A):or a salt thereof, wherein: Ring B is selected from: 9- to 16-membered fused heteroaryl and 6- to 16-membered fused heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from: RA; each RAis independently selected from:Attorney Docket No.52600-737601 halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O,=S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and R5is selected from: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d,-C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN;C1-3 alkyl substituted with one or more substituents independently selected from halogen, -OR10d, -SH, -S(C2-6 alkyl), -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; C4-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -Attorney Docket No.52600-737601 N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e,-C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, - OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN;C1-3 alkyl substituted with one or more substituents independently selected from halogen, -OR10e, -SH, -S(C2-6 alkyl), -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, - OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S,=N(R10e), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; C4-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10carbocycle and 3- to 10-memberedAttorney Docket No.52600-737601 heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g,-C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9g; ach R9bis independently selected from: hydrogen;Attorney Docket No.52600-737601 halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, - S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl; each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, - OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;Attorney Docket No.52600-737601 C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, - S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, - OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, - S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, - OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andeach R10b, R10d, R10e, and R10gis independently selected from: hydrogen; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -Attorney Docket No.52600-737601 NH(C1-6alkyl), C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, 3- to 10- membered heterocycle, and C1-6 haloalkyl; wherein when: (i) R5is -H, and (ii) R6is -H; then: (i) Ring B is a 9- to 16-membered fused heteroaryl or 6- to 16-membered heterocycloalkyl substituted with one or more substituents independently selected from: RA; (ii) each RAis independently selected from: fluoro, wherein: when Ring B is substituted with one fluoro group, then ring B is further substituted with one or more additional substituents independently selected from RA; and when Ring B is substituted with two fluoro groups, then ring B is a 4- to 8- membered fused heterocycle or a 10-16-membered heterocycle, each of which is optionally one or more substituents independently selected from: RA; bromo, iodo, -O(C3-6 alkyl), -O(CHF2), -O(CH2F), -O(C2-6 haloalkyl), -SR10b, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, - OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -OC(O)R10b, -NO2, =N(R10b), -N3, and -CN; C1 alkyl, wherein: no more than one RAis C1alkyl; and when Ring B is substituted with one C1alkyl, then ring B is further substituted with one or more additional substituents independently selected from RA, and said one or more additional substituents on Ring B does not comprise a C1alkyl; C1-2 alkyl substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -N(R10b)C(O)R10b, - N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3-to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C2 alkyl, n-propyl, C4-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C2 alkyl, C2- 6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -Attorney Docket No.52600-737601 N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2,-OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C3-10carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; and (iii) R8is selected from: hydrogen; C1-2alkyl substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, , -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl,Attorney Docket No.52600-737601 C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9g.

58. A compound represented by Formula (V):or a salt thereof, wherein: Ring B is a 4- to 16-membered fused heterocycle optionally substituted with one or more substituents independently selected from: RA; each RAis independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O,=S, =N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and R5is selected from:Attorney Docket No.52600-737601 hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN;C2-3 alkyl substituted with one or more substituents independently selected from halogen, -OR10d, -SH, -S(C2-6 alkyl), -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d,-C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; C1 alkyl, C4-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, - S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen;Attorney Docket No.52600-737601 halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, - OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN;C2-3alkyl substituted with one or more substituents independently selected from halogen, -OR10e, -SH, -S(C2-6 alkyl), -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, - OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S,=N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; C1alkyl, C4-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, - SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, - S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -Attorney Docket No.52600-737601 N(R10g)C(O)R10g,-C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9g; ach R9bis independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, - S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl; each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;Attorney Docket No.52600-737601 C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, - OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, - S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, - OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;each R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, - S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andAttorney Docket No.52600-737601 C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, - OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andeach R10b, R10d, R10e, and R10gis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, - NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and C1-6 haloalkyl wherein when: (i) R5is -H, and (ii) R6is -H; then: (i) each RAis independently selected from: fluoro, chloro, bromo, iodo, -OH, -O(C1-6 alkyl), -O(CHF2), -O(C2-6 haloalkyl), - SR10b, -N(C1-6alkyl)2, -NH(C1-6alkyl), -C(O)R10b, -N(R10b)C(O)R10b,- N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -OC(O)R10b, -NO2, =N(R10b), -N3, and -CN; C1 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =S,=N(R10b), -N3, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C2-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -Attorney Docket No.52600-737601 N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =S,=N(R10b), -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; C3-5 carbocycle, C7-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; and C6carbocycle substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; (ii) R8is selected from: hydrogen; C1-2 alkyl substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, =O, -CN, C3-10 carbocycle and 3- to 10- membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, whereinAttorney Docket No.52600-737601 each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; (iii) when Ring B is substituted with one fluoro, or when Ring B is substituted with two fluoro; then: Ring B is a *6-6 benzo-fused heterocycle, optionally further substituted with one or more RAin addition to the one fluoro or the two fluoro, wherein * represents the point of attachment to Formula (V); (iv) when Ring B is substituted with one methyl, then Ring B is a benzo-fused heterocycle selected from:, wherein n and m are both integers, each of which is independently selected from 0, 1, 2, and 3; each RA’is independently selected from -H and RA; and each RQis independently selected from -H, -F, -CN, -OH, -O(CH3), - O(CH2CH3), and -CF3; and (v) when Ring B is a *6-6 fused heterocycle or a *5-5 fused heterocycloalkyl, or a *5-6 fused heterocycle, or a *6-5 fused heterocycloalkyl, or a *5-5-6 fused heterocycle, wherein * represents the point of attachment to Formula (V), then Ring B is substituted with one or more substituents independently selected from RA.

59. The compound or salt of claim 57 or 58, wherein each RA is independently selected from:halogen, -OH, -O(CH3), -O(CF3), -SH, -SCH3, =O, -CN, -CH3, and -CF3.

60. The compound or salt of any one of claims 57 to 59, wherein R6 is selected from: -H.

61. The compound or salt of any one of claims 57 to 60, wherein R5 is selected from:hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d,-C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN;Attorney Docket No.52600-737601 C2-3alkyl substituted with one or more substituents independently selected from halogen, -OR10d, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; C1 alkyl and C4-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -NO2, =O, -CN, and C1-6 alkyl;62. The compound or salt of any one of claims 57 to 59, wherein: R5 together with R6 form a 5- to10- membered heterocycle or C5-10carbocycle, wherein the 5- to 10- membered heterocycle or C5-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d.

63. The compound or salt of any one of claims 57 to 62, wherein: R7 is -H, and R8 is -H.

64. The compound or salt of any one of claims 57 to 63, wherein: Ring B is an 8- to 12-memberedfused heterocycloalkenyl or an 8-12-membered heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: RA.

65. The compound or salt of any one of claims 57 to 61 or 63 to 64, wherein when: (i) R5 is -H, and(ii) R6is -H; then: (i) each RAis independently selected from: fluoro, wherein: when Ring B is substituted with one fluoro group, then ring B is further substituted with one or more additional substituents independently selected from RA; and when Ring B is substituted with two fluoro groups, then ring B is a 4- to 8-membered fused heterocycle or a 10-16-membered heterocycle, each of which is optionally one or more substituents independently selected from: RA; bromo, iodo, -O(C3-6alkyl), -O(CHF2), -O(C2-6haloalkyl), -CN, and -CF3; and -CH3, wherein: no more than one RAis C1 alkyl; and when Ring B is substituted with one C1 alkyl, then ring B is further substituted with one or more additional substituents independently selected from RA, and saidAttorney Docket No.52600-737601 one or more additional substituents on Ring B does not comprise a C1alkyl; and (ii) R8is selected from: -H; and66. (iii) Ring B is an optionally substituted benzo-fused 8- to 12-membered fused heterocycle. Thecompound or salt of any one of claims 57 to 65, wherein Ring B is a 10-membered benzo-fused heterocycle optionally substituted with: (i) one fluoro substituent and one methyl substituent; (ii) two fluoro substituents; or (iii) one methyl substituent and one substituent selected from: bromo, iodo, -O(C3-6 alkyl), -O(CHF2), -O(C2-6 haloalkyl), -CN, and -CF3.

67. The compound or salt of any one of claims 57 to 66, selected from a compound: of Table 5, or asalt of any one thereof.

68. A compound represented by Formula (VI):or a salt thereof, wherein: n is an integer selected from 0 and 1; X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); Y1is selected from C(R9bA), N, and N+(-O-); Y2is selected from C(R9bB), N, and N+(-O-); Y3is selected from C(R9bC), N, and N+(-O-); Y4is selected from C(R9bD), N, and N+(-O-); Y5is selected from C(R9bE), N, and N+(-O-); wherein no more than three of Y1, Y2, Y3, Y4, and Y5are N or N+(-O-); R1a, R1b, R1c, and R1d, are each independently selected from: hydrogen;Attorney Docket No.52600-737601 halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9a; RCis selected from: hydrogen; -CN, -C(O)R10c, -C(O)N(R10c)2, -C(O)OR10c;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, - N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -C(O)OR10c, -OC(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -Attorney Docket No.52600-737601 OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9c; or RZtogether with RCform a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; RZis selected from: hydrogen; -CN, -C(O)R10z, -C(O)N(R10z)2, and -C(O)OR10z;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from deuterium, halogen, -OR10z, - SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -C(O)OR10z, -OC(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, - S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9z; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9z; R5is selected from: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d,-C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -Attorney Docket No.52600-737601 N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e,-C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, - OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl,Attorney Docket No.52600-737601 C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e; R7is selected from: -C(O)R10f, -C(O)N(R10f)2, -C(O)OR10f, -S(O)R10f, and -S(O)2R10f; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f,-C(O)OR10f, -OC(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9f; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9f; R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1alkyl substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; andAttorney Docket No.52600-737601 C2-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-5 carbocycle, C6 cycloalkyl, C7-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g,-N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, - N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O,=S, =N(R10g), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1- 6 alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9ais independently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, - S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, - OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;R9bA, R9bB, R9bC, R9bD, and R9bEare each independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b;Attorney Docket No.52600-737601 C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, - S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl; each R9cis independently selected from: halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, - N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, - S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2, -OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, - OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), -N3, and -CN;each R9zis independently selected from: halogen, -OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10z, -SR10z, - N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -Attorney Docket No.52600-737601 OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, -OC(O)R10z, -S(O)R10z, - S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10z, -SR10z, -N(R10z)2, -C(O)R10z, -C(O)N(R10z)2, -N(R10z)C(O)R10z, -N(R10z)C(O)N(R10z)2, -OC(O)N(R10z)2, -N(R10z)C(O)OR10z, -C(O)OR10z, - OC(O)R10z, -S(O)R10z, -S(O)2R10z, -NO2, =O, =S, =N(R10z), -N3, and -CN;each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, - OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, - S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -Attorney Docket No.52600-737601 N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, - OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;each R9fis independently selected from: halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, - N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, - S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, - OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN; andeach R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, - S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, - OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andeach R10a, R10b, R10c, R10z, R10d, R10e, R10f, and R10gis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2,Attorney Docket No.52600-737601 -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, - NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and C1-6haloalkyl; wherein when n is 0; then: (i) R7is selected from: -C(O)R10f, -C(O)N(R10f)2, -C(O)OR10f, -S(O)R10f, and -S(O)2R10f; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, =S, =N(R10f), -N3, -CN, and C3 carbocycle, C5-10 carbocycle, 3- to 4-membered heterocycle, and 6- to 10- membered heterocycle wherein each C3carbocycle, C5-10carbocycle, 3- to 4- membered heterocycle, and 6- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9f; and C3-10carbocycle, 3- to 4-membered heterocycle, and 6- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, - C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O,=S, =N(R10f), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9f; (ii) R9bCis selected from: hydrogen; fluoro, chloro, iodo, -N3, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SR10b, - N(R10b)2, -C(O)R10b, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, - OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and-S(O)2R10b; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -Attorney Docket No.52600-737601 S(O)R10b, -S(O)2R10b, -NO2, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and 3- to10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl; (iii) when R9bAis methyl or when R9bBis methyl; then R9bDis selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b;C1alkyl substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, - OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; C2-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, - S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; and (iv) when R9bBis -O(CH3) or -F; then R9bCis selected from: hydrogen; halogen, -NO2, -N3, -CN, -OH, -O(C2-6 alkyl), -O(C1-6 haloalkyl), -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2,Attorney Docket No.52600-737601 -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b,and -S(O)2R10b; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, - S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; wherein when n is 1, then: (i) R8is selected from: hydrogen; -C(O)R10g, -C(O)N(R10g)2, -C(O)OR10g, -S(O)R10g, and -S(O)2R10g; C1-2 alkyl substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g,-C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -C(O)OR10g, -OC(O)R10g, -N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S,=N(R10g), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; andAttorney Docket No.52600-737601 C3-4carbocycle, C6cycloalkyl, C7-10carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, - C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2,=O, =S, =N(R10g), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9g; (ii) when X4is -C(F)-; then R1ais selected from hydrogen; halogen, -NO2, -N3, -CN, -O(C2-6alkyl), -O(C1-6haloalkyl), -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and-S(O)2R10a; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, - S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O,=S, =N(R10a), -N3, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a.

69. The compound or salt of claim 68, wherein the compound is not compound: 832, 833, 840, or asalt of any thereof.

70. The compound or salt of any one of claims 68 or 69, wherein X1 is selected from: C(H), X2 isselected from: C(H), X3 is selected from: C(H), and X4 is selected from: C(H).Attorney Docket No.52600-73760171. The compound or salt of any one of claims 68 to 70, wherein n is 0.

72. The compound or salt of any one of claims 68 to 70, wherein n is 1.

73. The compound or salt of any one of claims 68 to 72, wherein R1a, R1b, R1c, and R1d, are eachindependently selected from: hydrogen, -F, -OH, and -O(CH3).

74. The compound or salt of any one of claims 68 to 73, wherein RC is selected from: -H.

75. The compound or salt of any one of claims 68 to 74, wherein RZ is selected from: -CH3 and -H.

76. The compound or salt of any one of claims 68 to 75, wherein RZ is selected from: -H.

77. The compound or salt of any one of claims 68 to 76, wherein R6 is selected from: -H.

78. The compound or salt of any one of claims 68 to 77, wherein R5 is selected from: hydrogen.

79. The compound or salt of any one of claims 68 to 78, wherein: R7 is -C1-6 alkyl optionallysubstituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, - N(R10f)2, =O, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9f.

80. The compound or salt of any one of claims 68 to 79, wherein: R7 is -C1-6 alkyl.

81. The compound or salt of any one of claims 68 to 80, wherein: R7 is -CH3 or isopropyl.

82. The compound or salt of any one of claims 68 to 81, wherein: R8 is -H.

83. The compound or salt of any one of claims 68 to 82, wherein: R9bA, R9bB, R9bC, R9bD, and R9bE areeach independently selected from: hydrogen; -F, -Cl, -OCH3, -CH3, -CF3, and -CHF2.

84. The compound or salt of any one of claims 68 to 83, wherein: Y1 and Y5 are each independentlyselected from: C(H), C(F), and C(OCH3); and Y2and Y4are each independently selected from: C(H), C(F), C(CH3), C(CF3), and C(CHF2); and Y3is selected from: C(H), C(OCH3), C(F), C(Cl).

85. The compound or salt of any one of claims 68 to 84, wherein: RZ, RC, Y1, Y2, Y3, Y4, and Y5form a moiety selected from:

86. The compound or salt of any one of claims 68 to 85, wherein when n is 0; then:(i)R7is selected from C1-6 alkyl; and (ii) R9bCis selected from hydrogen, fluoro, chloro, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), - CH3, -CHF2, and -CF3; and (iii) when R9bAis methyl or when R9bBis methyl; then: R9bDis selected from: hydrogen and fluoro; and (iv) when R9bBis -O(CH3) or -F; then R9bCis selected from: hydrogen, halogen, -CN, -CH3, -CF3, and CHF2.Attorney Docket No.52600-73760187. The compound or salt of any one of claims 68 to 86, wherein when n is 1; then:(i) R8is selected from -H; and (ii) X4is -C(F)-; then R1ais selected from: hydrogen, fluoro, -CN, -CH3, and -CF3.

88. The compound or salt of claim 68, selected from compound: 601, 603, and 605, or a salt of anyone thereof.

89. A pharmaceutical composition comprising the compound or salt of any one of claims 1 to 88 anda pharmaceutically acceptable excipient.

90. A method of modulating myosin, modulating skeletal muscle myosin, or activating skeletalmuscle myosin, the method comprising administering to a patient in need thereof a therapeutically effective amount of a compound or salt of any one of claims 1 to 88 or the pharmaceutical composition of claim 89.

91. A method of activating skeletal muscle myosin, the method comprising administering to a patientin need thereof a compound or salt of Formula (VII),or a salt thereof, wherein: X1is selected from C(R1a), N, and N+(-O-); X2is selected from C(R1b), N, and N+(-O-); X3is selected from C(R1c), N, and N+(-O-); X4is selected from C(R1d), N, and N+(-O-); wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); R1a, R1b, R1c, and R1d, are each independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle isAttorney Docket No.52600-737601 optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a; R2is selected from C1-2 alkyl substituted with one or more substituents independently selected from halogen, -OR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =S, -N3, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C3-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =S, -N3, -CN, C3-10 carbocycle, and 3- to10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10carbocycle and 3- to 18-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl,and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; orAttorney Docket No.52600-737601 R2together with R7form a 3- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2,-N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C3-10carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2,=O, =S, =N(R10b), -N3, -CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; R5is selected from: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-Attorney Docket No.52600-737601 membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9d; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d; R6is selected from: hydrogen; halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, - OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, -N3, and -CN;C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -C(O)OR10e, -OC(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6Attorney Docket No.52600-737601 alkynyl is optionally substituted with one or more substituents independently selected from R9e; or R6together with R5form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9e; R7is selected from: hydrogen; -C(O)R10f, -C(O)N(R10f)2, -C(O)OR10f, -S(O)R10f, and -S(O)2R10f; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f,-C(O)OR10f, -OC(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9f; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, -CN, C1-6 alkyl,C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9f; R8is selected from: hydrogen; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -CN, C3-10carbocycle and 3- to 10- membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -Attorney Docket No.52600-737601 OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9g; each R9ais independently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, - S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, - OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -N3, and -CN;each R9bis independently selected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10b, -SR10b, -N(R10b)2, =O, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -OC(O)R10b, -S(O)R10b, and -S(O)2R10b; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, - S(O)2R10b, -NO2, =S, =N(R10b), -N3, -CN, C3-10 carbocycle and 3- to 10-memberedheterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -Attorney Docket No.52600-737601 OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl; each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, - OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, and -CN;each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, - S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2, -OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, - OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), -N3, and -CN;each R9fis independently selected from: halogen, -OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN;Attorney Docket No.52600-737601 C1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, - N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, -OC(O)R10f, -S(O)R10f, - S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10f, -SR10f, -N(R10f)2, -C(O)R10f, -C(O)N(R10f)2, -N(R10f)C(O)R10f, -N(R10f)C(O)N(R10f)2, -OC(O)N(R10f)2, -N(R10f)C(O)OR10f, -C(O)OR10f, - OC(O)R10f, -S(O)R10f, -S(O)2R10f, -NO2, =O, =S, =N(R10f), -N3, and -CN; andeach R9gis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN;C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, - S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g, -N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, - OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =O, =S, =N(R10g), -N3, and -CN; andeach R10a, R10b, R10d, R10e, R10f, and R10gis independently selected from: hydrogen; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -Attorney Docket No.52600-737601 NH(C1-6alkyl), C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, 3- to 10- membered heterocycle, and C1-6 haloalkyl; wherein when R2together with R7form a heterocycle selected from piperazine; then the piperazine formed from R2and R7is optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, and -CN;C2-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN; andC3-5carbocycle, C6cycloalkyl, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b; and wherein when: (i) R2is a substituted or unsubstituted 5-membered heteroaryl, substituted or unsubstituted 6-membered heteroaryl, or substituted or unsubstituted 6-membered aryl, and (ii) R6is -H; then: (a) R5is selected from: hydrogen; halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3,and -CN; C1-3alkyl, C5-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d,-C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -Attorney Docket No.52600-737601 OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, -CN, C3-4 carbocycle, C6 aryl, C7-10 carbocycle, 3- to 5- membered heterocycloalkyl, 6-membered heteroaryl, and 7- to 10- membered heterocycle; wherein each C3-4carbocycle, C7-10carbocycle, 3- to 5-membered heterocycloalkyl, 6-membered heteroaryl, and 7- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; wherein each C6aryl is substituted with one or more substituents substituent independently selected from: Cl, -Br, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle; C3-4 alkyl, substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d,-C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, - OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), -N3, -CN, C1-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9d; and (b) R2is optionally substituted with one or more substituents selected from: halogen, - OH, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -N3, -CN, C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b.Attorney Docket No.52600-73760192. The method of claim 90 or 91, or the compound or salt of any one of claims 1 to 88, or thepharmaceutical composition of claim 89, wherein the compound or salt is not: a compound of List 1, or a salt of any thereof.

93. The method of any one of claims 91 to 92, wherein X1 is selected from: C(OH), N, C(OCH3),C(F), C(H), C(OH), C(CN), and C(CH3); and X2is selected from: C(H), N, C(F), and C(CH)3; and X3 is selected from: C(H) and N; and X4 is selected from: C(H), C(F), and N.

94. The method of any one of claims 91 to 93, wherein X4 is selected from: C(H).

95. The method of any one of claims 91 to 94, wherein R1a, R1b, R1c, and R1d, are each independentlyselected from: hydrogen; halogen, -NO2, -N3, -CN, -OR10a, -SR10a, and -N(R10a)2; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, =O, -CN, and C1-6alkyl.

96. The method of any one of claims 91 to 95, wherein R1a, R1b, R1c, and R1d, are each independentlyselected from: hydrogen, -F, -OH, -O(CH3), -CN, and -CH3.

97. The method of any one of claims 91 to 96, wherein R2 together with R7 form a 3- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -NO2, =O, and -CN; C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -NO2, =O, -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -NO2, =O, -CN, C1-6alkyl, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b.Attorney Docket No.52600-73760198. The method of any one of claims 91 to 97, wherein R6 is selected from: -H.

99. The method of any one of claims 91 to 98, wherein R5 is selected from:halogen; C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -NO2, =O, -CN, and C1-6alkyl, wherein each C1-6alkyl is optionally substituted with one or more substituents independently selected from halogen and -OH., , , , , , , , ,Attorney Docket No.52600-737601101. The method of any one of claims 91 to 99, wherein: R5 is -H.

102. The method of any one of claims 91 to 97, wherein: R5 together with R6 form a 5- to 10-membered heterocycle or C5-10carbocycle, wherein the 5- to 10- membered heterocycle or C5-10carbocycle is optionally substituted with one or more substituents independently selected from R9d.

103. The method of any one of claims 91 to 97, wherein: R8 is -H.

104. The method of any one of claims 91 to 103, wherein: each R9b is independently selectedfrom: -CH3, -F, -OCH3, -OCH2CH3, -OCF3, =O, and -CN.

105. The method of any one of claims 91 to 104, wherein: R7 is selected from: -H and C1-6 alkyl.

106. The method of any one of claims 91 to 105, wherein: R7 is selected from: -H.

107. The method of any one of claims 91 to 106, wherein: R2 is selected from: C1-2 alkylsubstituted with one or more substituents independently selected from halogen, -OH, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9b.

108. The method of any one of claims 91 to 107, wherein: R2 is selected from:,Attorney Docket No.52600-737601109. The method of any one of claims 91 to 103, wherein R2 together with R7 form a 3- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, =O, and -CN; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -NO2, =O, -CN, C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6alkylC3-10carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b.

110. The method of any one of claims 91 to 103 or claim 109, wherein R2 together with R7 form a6- to 14-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, =O, and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen.

111. The method of any one of claims 91 to 103 or 109 to 110, wherein R2 together with R7 form aheterocycle selected from:Attorney Docket No.52600-737601112. The method of any one of claims 91 to 111, wherein the compound is selected from acompound of Table 1, Table 2, Table 3, Table 4, and Table 5, or a salt of any one thereof.

113. The method of any one of claims 91 to 112, the method further comprising administering anadditional active agent.

114. The method of any one of claims 91 to 113, wherein the method treats a metabolic disease, aneuromuscular condition, a skeletal muscular condition, sarcopenia, muscle wasting, muscle spasm, or the method induces weight loss, or the method induces muscle gain, in a subject in need thereof.

115. A method of treating a metabolic disease, a neuromuscular condition, a skeletal muscularcondition, sarcopenia, muscle wasting, muscle spasm, inducing weight loss, or of inducing muscle gain in an individual in need thereof, the method comprising administering a therapeutically effective amount of the compound or salt of any one of claims 1 to 88 or the pharmaceutical composition of claim 89 using the method of any one of claims 91 to 114.

116. The method of any one of claims 91 to 115, further comprising the administration of asecond therapeutic agent, wherein the second therapeutic agent comprises a GLP-1 modulator or SGLT2 modulator, GIP modulator, a secretagogue, or alpha-glucosidase modulator.

117. A method of extending the amount of time muscle fibers reside in a DRX state or increasingthe population of muscle fibers residing in the DRX state, the method comprising administering to a patient in need thereof a the compound or salt of any one of claims 1 to 88 or the pharmaceutical composition of claim 89 using the method of any one of claims 91 to 114.

118. The method of claim 117, wherein the amount of time muscle fibers reside in a DRX state isincreased by 5% or more; or wherein the population of muscle fibers residing in the DRX state is increased by 5% or more; or wherein the resting energy consumption rate of the subject is increased 5% or more.

119. A method of modulating skeletal muscle myosin, the method comprising administering to apatient in need thereof a therapeutically effective amount of a compound of Formula (VII).Attorney Docket No.52600-737601120. The compound or salt of claim 1, selected from compound: 101, 102, 103, 104, 106, 106,107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, B1, B2, B3, B4, B5, B6, B7, B8, B9, B10, B11, B12, B13, B14, B15, B16, B17, B18, B19, B20, B21, B22, B23, B24, B25, B26, B27, B28, B29, B30, B31, B32, B33, B34, B35, B36, B37, B38, B39, B40, B41, B42, B43, B44, B45, B46, B47, B48, B49, B50, B51, B52, B53, B54, B55, B56, B57, B58, B59, B60, B61, B62, B63, B64, B65, B66, B67, B68, B69, B70, B71, B72, B73, B74, B75, B76, B77, B78, B79, B80, B81, B82, B83, B84, B85, B86, B87, B88, B89, B90, B91, B92, B93, B94, B95, B96, B97, B98, B99, B100, B101, B102, B103, B104, B105, B106, B107, B108, B109, B110, B111, B112, B113, B114, B115, B116, B117, B118, B119, B120, B121, B122, B123, B124, B125, B126, B127, B128, B129, B130, B131, B132, B133, B134, B135, B136, B137, B138, B139, B140, B141, B142, B143, B144, B145, B146, B147, B148, B149, B150, B151, B152, B153, B154, B155, B156, B157, B158, B159, B160, B161, B162, B163, B164, B165, B166, B167, B168, B169, B170, B171, B172, B173, B174, B175, B176, B177, B178, B179, B180, B181, B182, B183, B184, B185, B186, B187, B188, B189, B190, B191, B192, B193, B194, B195, B196, B197, B198, B199, B200, B201, B202, B203, B204, B205, B206, and B207, or a salt of any one thereof.

121. The compound or salt of claim 36, selected from compound: 301, 302, 303, 304, 305, 306,307, 308, or a salt of any one thereof.

122. The method of any one of claims 91 to 111, wherein the compound is selected from: 101,102, 103, 104, 106, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, B1, B2, B3, B4, B5, B6, B7, B8, B9, B10, B11, B12, B13, B14, B15, B16, B17, B18, B19, B20, B21, B22, B23, B24, B25, B26, B27, B28, B29, B30, B31, B32, B33, B34, B35, B36, B37, B38, B39, B40, B41, B42, B43, B44, B45, B46, B47, B48, B49, B50, B51, B52, B53, B54, B55, B56, B57, B58, B59, B60, B61, B62, B63, B64, B65, B66, B67, B68, B69, B70, B71, B72, B73, B74, B75, B76, B77, B78, B79, B80, B81, B82, B83, B84, B85, B86, B87, B88, B89, B90, B91, B92, B93, B94, B95, B96, B97, B98, B99, B100, B101, B102, B103, B104, B105, B106, B107, B108, B109, B110, B111, B112, B113, B114, B115, B116, B117, B118, B119, B120, B121, B122, B123, B124, B125, B126, B127, B128, B129, B130, B131, B132, B133, B134, B135, B136, B137, B138, B139, B140, B141, B142, B143, B144, B145, B146, B147, B148, B149, B150, B151, B152, B153, B154, B155, B156, B157, B158, B159, B160, B161, B162, B163, B164, B165, B166, B167, B168, B169, B170, B171, B172, B173, B174, B175, B176, B177, B178, B179, B180, B181,Attorney Docket No.52600-737601 B182, B183, B184, B185, B186, B187, B188, B189, B190, B191, B192, B193, B194, B195, B196, B197, B198, B199, B200, B201, B202, B203, B204, B205, B206, B207, 201, 202, 203, 204, 205, 301, 302, 303, 304, 305, 306, 307, 308, 401, 402, 403, 404, A405, A406, 501, 502, 503, 504, 505, 506, 507, 508, 509, 510, 601, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 701, 801, 802, 803, 804, 809, 810, 811, 812, 813, 814, 815, 816, 817, 818, 819, 820, 821, 822, 823, 824, 825, 826, 827, 828, 829, 830, 831, 832, 833, 834, 835, 836, 837, 838, 839, 840, or a salt of any one thereof.

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