Sequential balloon pulsatile blood pump for artificial uterus, and system and method

Abstract

The present invention relates to the technical field of medical instruments. Provided are a sequential balloon pulsatile blood pump for an artificial uterus, and a system and a method. The blood pump comprises: a pump body, which is arranged in a blood flow circuit of an artificial placenta and comprises a first pump chamber and a second pump chamber, wherein the first pump chamber and the second pump chamber are connected in parallel by means of a conduit, and two ends of the conduit are respectively an inlet end and an outlet end of blood, the inlet end being in communication with an umbilical artery of a fetus, and the outlet end being in communication with an umbilical vein of the fetus by means of an oxygenator; a controller, which is in communication connection with both a first air pouch assembly and a second air pouch assembly; and a heart acquisition unit, which is arranged on the outer surface of an artificial uterus and is in communication connection with the controller. The present invention has advantages, such as being capable of generating a pulsating blood flow, adapting to the high heart rate of a fetus, not affecting a cardiac afterload balance of the fetus, and preventing umbilical vascular intubation spasm.

Description

Sequential balloon pulsatile blood pump, system and method for artificial uterus TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a sequential balloon pulsatile blood pump, system and method for artificial uterus. BACKGROUND

[0002] Extremely preterm birth remains a major cause of neonatal death and serious long-term morbidity. The basic principle of artificial placenta (AP) and artificial womb (AW) technology is a more physiologically meaningful approach, i.e. to replace the function of the placenta and provide an environment similar to the uterus. In the artificial placenta circuit, the blood pump is one of the core parts, which provides power for blood flow in the pipeline to restore physiological fetal flow by overcoming the resistance of the oxygenator.

[0003] Currently, the blood pumps used in artificial placenta in clinical applications mainly include roller pumps and centrifugal pumps. Whether it is a centrifugal pump or a roller pump, the suction during the process of discharging fetal heart blood will interfere with the natural heart pump function, leading to unbalanced afterload and causing heart strain. In addition, due to the relatively thin umbilical artery and vein of the fetus, constant flow pumps are prone to cause umbilical artery and vein spasm. SUMMARY

[0004] In order to solve the technical problems in the prior art that whether it is a centrifugal pump or a roller pump, the suction during the process of discharging fetal heart blood will interfere with the natural heart pump function, leading to unbalanced afterload and causing heart strain. In addition, due to the relatively thin umbilical artery and vein of the fetus, constant flow pumps are prone to cause umbilical artery and vein spasm, the embodiments of the present application provide a sequential balloon pulsatile blood pump, system and method for artificial uterus. The technical solution is as follows:

[0005] In one aspect, a sequential balloon pulsatile blood pump for artificial uterus is provided, the blood pump comprising:

[0006] a pump body, the pump body being arranged in a blood flow circuit of an artificial placenta, the pump body comprising a first pump cavity and a second pump cavity;

[0007] wherein a first balloon assembly is arranged in the first pump cavity, the first balloon assembly comprising a first balloon, a second balloon and a third balloon arranged in sequence;

[0008] a second balloon assembly is arranged in the second pump cavity, the second balloon assembly comprising a fourth balloon, a fifth balloon and a sixth balloon arranged in sequence;

[0009] The first pump cavity and the second pump cavity are connected in parallel through a conduit, two ends of the conduit are respectively an inlet end and an outlet end of blood, the inlet end is connected with the umbilical artery of the fetus, and the outlet end is connected with the umbilical vein of the fetus through an oxygenator.

[0010] A controller, which is in communication connection with the first balloon assembly and the second balloon assembly respectively;

[0011] A heart collection unit, which is arranged on the outer surface of the artificial uterus and in communication connection with the controller.

[0012] Optionally, the volume of the second balloon after inflation is greater than the volume of the first balloon and the third balloon after inflation.

[0013] Optionally, the volume of the fifth balloon after inflation is greater than the volume of the fourth balloon and the sixth balloon after inflation.

[0014] Optionally, the controller comprises an adjusting module, which can adjust the beating frequency and the beating intensity of the first balloon assembly and the second balloon assembly according to the data provided by the heart collection unit.

[0015] Optionally, a pressure sensor is further arranged in the pump body, which is in communication connection with the controller, and is used to acquire the pressure data of the blood in the pump body and send the pressure data to the controller.

[0016] Optionally, connection joints are arranged at two ends of the conduit respectively, which are used to detachably connect with the umbilical artery of the fetus and the oxygenator respectively.

[0017] Optionally, the pump body further comprises a temperature adjusting device, which is arranged in the pump body and is used to adjust the temperature of the blood in the pump body.

[0018] In one aspect, a sequential balloon beating blood pump system for an artificial uterus is provided, comprising an artificial uterus, an oxygenator and the sequential balloon beating blood pump for an artificial uterus according to any one of the above.

[0019] The artificial uterus is used to accommodate a fetus, and two ends of the conduit of the pump body are respectively an inlet end and an outlet end of blood, the inlet end is connected with the umbilical artery of the fetus.

[0020] In one aspect, a control method of a sequential balloon beating blood pump for an artificial uterus is provided, which is applied to the sequential balloon beating blood pump for an artificial uterus according to any one of the above, and the method comprises:

[0021] arranging a pump body in a blood flow loop of an artificial placenta;

[0022] acquire a blood supply time and a blood discharge time of the heart based on the heart acquisition unit, and send the blood supply time and the blood discharge time to a controller;

[0023] According to the data provided by the heart acquisition unit, the controller adjusts the pulsation frequency, the pulsation intensity and the pulsation sequence of at least one of the first airbag assembly and the second airbag assembly.

[0024] Optionally, the controller adjusts the pulsation frequency, the pulsation intensity and the pulsation sequence of at least one of the first airbag assembly and the second airbag assembly according to the data provided by the heart acquisition unit, including:

[0025] In the counterpulsation mode, the controller adjusts the pulsation frequency, the pulsation intensity and the pulsation sequence of the first airbag assembly according to the data provided by the heart acquisition unit;

[0026] In the synchronous mode, the controller adjusts the pulsation frequency, the pulsation intensity and the pulsation sequence of the first airbag assembly and the second airbag assembly respectively according to the data provided by the heart acquisition unit.

[0027] The technical scheme provided by the embodiment of the present application has at least the following beneficial effects:

[0028] The sequential balloon pulsation blood pump for artificial uterus provided by the present application can generate pulsation blood flow, can adapt to high heart rate of the fetus, and does not affect the balance of the afterload of the fetal heart, and has the advantages of avoiding umbilical blood vessel intubation spasm. BRIEF DESCRIPTION OF DRAWINGS

[0029] In order to more clearly illustrate the technical scheme in the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiment description. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without creative labor.

[0030] Fig. 1 is a working principle diagram of a sequential balloon pulsation blood pump for artificial uterus provided by an embodiment of the present application;

[0031] Fig. 2 is a structural diagram of a pump body 1 provided by an embodiment of the present application;

[0032] Fig. 3 is one of working principle diagrams of a pump body 1 provided by an embodiment of the present application;

[0033] Fig. 4 is another working principle diagram of a pump body 1 provided by an embodiment of the present application;

[0034] Fig. 5 is a flow chart of a sequential balloon pulsation method for artificial uterus provided by an embodiment of the present application;

[0035] Figure 6 is a third working principle diagram of the pump body 1 according to an embodiment of the present application;

[0036] Figure 7 is a fourth working principle diagram of the pump body 1 according to an embodiment of the present application.

[0037] Reference signs:

[0038] 1, pump body; 10, first pump cavity; 110, first balloon assembly; 111, first balloon; 112, second balloon; 113, third balloon; 20, second pump cavity; 210, second balloon assembly; 211, fourth balloon; 212, fifth balloon; 213, sixth balloon;

[0039] 2, catheter; 230, inlet end; 231, umbilical artery; 220, outlet end; 221, umbilical vein;

[0040] 3, oxygenator;

[0041] 4, controller;

[0042] 5, heart collection unit;

[0043] 6, gas source;

[0044] 7, fetus

[0045] 8, artificial uterus. DETAILED DESCRIPTION

[0046] The technical solutions in the present application will be described below with reference to the drawings.

[0047] In the embodiments of the present application, the words such as "example", "for example" are used to represent an example, illustration or description. Any embodiment or design scheme described as "example" in the present application should not be interpreted as more preferred or more advantageous than other embodiments or design schemes. Rather, the word "example" is intended to present the concept in a specific manner. In addition, in the embodiments of the present application, the meaning expressed by "and / or" can be both, or can be one of the two.

[0048] In order to make the technical problems, technical solutions and advantages of the present application clearer, the following will be described in detail with reference to the drawings and specific embodiments.

[0049] The embodiments of the present application provide a sequential balloon pulsatile blood pump for an artificial uterus. Figure 1 is a working principle diagram of a sequential balloon pulsatile blood pump for an artificial uterus according to an embodiment of the present application. Please refer to Figure 1. The blood pump comprises a pump body 1, a controller 4 and a heart collection unit 5.

[0050] The pump body 1 is arranged in a blood flow loop of an artificial placenta, the artificial placenta is located in an artificial uterus 8, and the pump body 1 is used for driving circulation of blood. FIG. 2 is a structural diagram of a pump body 1 provided by an embodiment of the present application, please refer to FIG. 2. The pump body 1 comprises a first pump cavity 10 and a second pump cavity 20, the first pump cavity 10 is provided with a first balloon assembly 110, when the first balloon assembly 110 expands, blood in the pump cavity will be pushed out, when the first balloon assembly 110 contracts, new blood will be sucked in. The second pump cavity 20 is provided with a second balloon assembly 210, the working principle of the second balloon assembly 210 is the same as that of the first balloon assembly 110.

[0051] Specifically, the first balloon assembly 110 comprises a first balloon 111, a second balloon 112 and a third balloon 113 arranged in sequence, and the second balloon assembly 210 comprises a fourth balloon 211, a fifth balloon 212 and a sixth balloon 213 arranged in sequence. All the balloons are fixed on the inner wall of the pump cavity through the gas guide pipes connected thereto, the balloons are independent of each other and run in the pump cavity and expand and contract in the pump cavity. Each balloon has a corresponding pump body 1 gas source 6 as a driving device, and the balloon and the gas source 6 are connected in communication through the gas guide pipes. The expansion and contraction of the balloon is realized by the inflation and deflation of the balloon by the control equipment.

[0052] Moreover, the first pump cavity 10 and the second pump cavity 20 are connected in parallel through a conduit 2, two ends of the conduit 2 are an inlet end 230 and an outlet end 220 of blood respectively, and they constitute a circulation path of blood. The inlet end 230 is connected in communication with an umbilical artery 231 of a fetus 7, and is used for receiving blood from the fetus 7. The outlet end 220 is connected in communication with an umbilical vein 221 of the fetus 7 through an oxygenator 3. When the blood passes through the oxygenator 3, oxygen will be supplemented and waste will be removed, so as to simulate the oxygen exchange process of the fetus 7 in the mother's body.

[0053] A controller 4 is in communication connection with the first balloon assembly 110 and the second balloon assembly 210 respectively. Specifically, the controller 4 is in communication connection with the gas source 6 in the first balloon assembly 110 and the second balloon assembly 210, so as to control the expansion and contraction of the balloon assembly.

[0054] A heart collection unit 5 is arranged on the outer surface of the artificial uterus 8 and is in communication connection with the controller 4. The heart collection unit 5 can monitor the heartbeat condition of the fetus 7 in real time and transmit data to the controller 4. The controller 4 adjusts the beating frequency and strength of the balloon assembly according to the data, so as to ensure that the blood circulation is consistent with the heartbeat of the fetus 7. Therefore, the controller 4 can control the expansion and contraction of the balloon assembly according to the preset program and the data of the heart collection unit 5, so as to simulate the beating process of the heart.

[0055] When the blood pump is working, the controller 4 controls the inflation and deflation of the first balloon assembly 110 and the second balloon assembly 210 according to the data provided by the heart collection unit 5. For example, when the first balloon assembly 110 inflates, it pushes the blood in the first pump cavity 10 out and into the oxygenator 3 through the catheter 2; at the same time, the second balloon assembly 210 deflates and sucks in new blood. Then, the second balloon assembly 210 inflates and pushes the blood in the second pump cavity 20 out and into the oxygenator 3 again; at the same time, the first balloon assembly 110 deflates and is ready to suck in new blood. In this way, the two balloon assemblies work alternately to achieve continuous circulation of blood.

[0056] Specifically, when the blood pump is working, the two branches in the pump cavity can work simultaneously or separately. For example, when a single branch works, after the first balloon 111 (or the fourth balloon 211) deflates, the second balloon 112 (or the fifth balloon 212) deflates, and the third balloon 113 (or the sixth balloon 213) remains inflated, a low pressure is generated in the pump cavity to suck blood into the pump cavity; then, the first balloon 111 (or the fourth balloon 211) inflates, the second balloon 112 (or the fifth balloon 212) inflates, the pressure in the pump cavity rises, and the third balloon 113 (or the sixth balloon 213) deflates, and blood is discharged from the outlet end 220. When two branches work, the two branches work alternately.

[0057] It should be noted that the first balloon 111 is used to simulate the mitral valve and control the blood flow into the first pump cavity 10, the second balloon 112 simulates the left ventricle and can simulate the left ventricular contraction and diastole, and the third balloon 113 simulates the aortic valve and controls the blood flow out of the first pump cavity 10. As shown in FIG. 3, during the diastolic phase of the heart, the first balloon 111 and the second balloon 112 deflate, the blood inlet side of the first pump cavity 10 opens, the third balloon 113 inflates, and the blood outlet side of the first pump cavity 10 closes, and blood flows into the first pump cavity 10. As shown in FIG. 4, during the systolic phase of the heart, the first balloon 111 inflates, the blood inlet side of the first pump cavity 10 closes, at the same time, the third balloon 113 deflates, the second balloon 112 inflates first, and gradually squeezes the blood in the first pump cavity 10 from the blood inlet side to the outlet side. Then, the third balloon 113 inflates, the first balloon 111 and the second balloon 112 deflate, and blood reflows into the first pump cavity 10. Repeating this process, pulsatile blood flow is obtained, and the function of assisting the heart is completed.

[0058] That is, by controlling the first balloon assembly 110 and the second balloon assembly 210 through the controller 4, pulsatile blood flow can be generated, the pulsatile blood flow generated by the blood pump can adapt to the high heart rate of the fetus 7, and the balance of the afterload of the heart of the fetus 7 is not affected, avoiding spasm of the umbilical blood vessel cannula and other advantages.

[0059] The pulsatile blood pump is driven by the inflation and expansion of the balloon, which is more gentle than the rotation of the impeller, reduces the stimulation to the umbilical blood vessel wall, and can effectively avoid the spasm of the umbilical vein 221 and the umbilical artery 231 cannula.

[0060] In addition, the heart rate of the fetus 7 is high, and the synchronous working mode of the pulsatile pump can adapt to the characteristics of the high heart rate of the fetus 7. The working frequency of each pump is only half of the heart rate of the fetus 7, compared with the blood pump driven by the high-speed rotation of the rotor, the shear force generated by the present application is obviously reduced, and the problem of significantly increased hemolysis index caused by high speed of the centrifugal pump is avoided.

[0061] The sequential balloon pulsatile blood pump for the artificial uterus provided by the present application can generate pulsatile blood flow, can adapt to the high heart rate of the fetus 7, and does not affect the balance of the afterload of the heart of the fetus 7, and has the advantages of avoiding spasm of the umbilical blood vessel cannula.

[0062] In the embodiments provided by the present application, the pump body 1 has a pump shell, which is a cylindrical cavity structure, and the two ends thereof are the inlet end 230 and the outlet end 220 of the pump. When each balloon is contracted, it can be contracted by the elasticity of the balloon itself, or it can be contracted by extracting gas through the gas source 6, that is, various forms can be used to achieve the purpose of simulating the contraction of the balloon. During operation, the running speed of the gas source 6 can be controlled to achieve the purpose of controlling the contraction or contraction speed.

[0063] The electrocardiogram acquisition unit can include an electrocardiogram acquisition patch that is attached to the outer surface of the artificial uterus 8 without directly contacting the fetus 7. According to the human electrocardiogram data of the fetus 7 collected by the electrocardiogram acquisition patch, each gas source 6 is controlled individually, which is more scientific and intelligent. This unit is responsible for monitoring the activity of the heart, which can include heart rate, heart rhythm, cardiac output and other key indicators. It will transmit these data to the controller 4 in real time.

[0064] In one embodiment provided by the present application, the volume of the second balloon 112 after expansion is greater than the volume of the first balloon 111 and the third balloon 113 after expansion. The second balloon 112 can be used to occupy a larger space in the first pump cavity 10 to control the blood flow.

[0065] In one embodiment provided by the present application, the volume of the fifth balloon 212 after expansion is greater than the volume of the fourth balloon 211 and the sixth balloon 213 after expansion. The fifth balloon 212 can be used to occupy a larger space in the first pump cavity 10 to control the blood flow.

[0066] In an embodiment provided by the present application, the controller 4 comprises an adjustment module, which can adjust the beating frequency and intensity of the first balloon assembly 110 and the second balloon assembly 210 according to the data provided by the heart acquisition unit 5. That is, the adjustment module can adjust the beating parameters of the balloon assemblies. The inflation and deflation of the balloon assemblies are controlled based on the beating frequency and intensity acquired by the heart acquisition unit 5, so as to simulate the beating process of the heart. For example, if the heart acquisition unit 5 shows that the heart rate is too low, the adjustment module can increase the beating frequency of the balloon assemblies to stimulate the heart. The adjusted balloon assemblies will again affect the state of the heart, and the heart acquisition unit 5 will continue to monitor these changes and feed back the new data to the adjustment module. In this way, a closed-loop feedback system is formed, which can continuously optimize the use effect of the pump body 1.

[0067] In an embodiment provided by the present application, a pressure sensor is further arranged in the pump body 1, which is in communication connection with the controller 4. The pressure sensor is used to acquire the pressure data of the blood in the pump body 1 and send the pressure data to the controller 4. Through the data detected by the pressure sensor, the working state of the pump body 1, the blood flow condition and possible abnormalities can be understood. After receiving these data, the controller 4 analyzes and processes them. According to the analysis result, the controller 4 can adjust the beating frequency, beating intensity and other parameters of the balloon assemblies, so as to ensure that the blood pressure in the pump body 1 remains within a safe and stable range.

[0068] Further, if the controller 4 detects abnormal pressure data (such as excessively high or low pressure value), it can immediately take measures such as suspending the work of the pump body 1, issuing an alarm, etc., to prevent possible damage or failure.

[0069] In an embodiment provided by the present application, the two ends of the catheter 2 are respectively provided with connection joints for detachable connection with the umbilical artery 231 of the fetus 7 and the oxygenator 3.

[0070] Among them, the catheter 2 is responsible for establishing a blood flow channel between the umbilical artery 231 of the fetus 7 and the oxygenator 3. And the above-mentioned connection joints are designed to be detachable, so that the catheter 2 can be conveniently connected to the target equipment, and also can be easily detached without damaging the equipment.

[0071] In an embodiment provided by the present application, the pump body 1 further comprises a temperature adjusting device arranged in the pump body 1 for adjusting the temperature of the blood in the pump body 1. The temperature adjusting device can ensure that the blood remains within a preset temperature range during circulation, which is crucial for maintaining the vital signs of the fetus 7 and the treatment effect. Once an abnormal temperature is monitored, the temperature adjusting device will immediately start to adjust the temperature of the blood back to the preset range through heating or cooling.

[0072] Specifically, the temperature adjusting device can be arranged at the inlet end 230 or the outlet end 220, and the embodiment is not limited in this aspect.

[0073] The blood pump is specifically introduced as follows:

[0074] The sequential balloon pulsatile blood pump provided by the application comprises a pump body 1 and a driving device thereof, the driving device comprises a gas source 6 corresponding to the balloon and the like, and the balloon and the gas source 6 are connected in communication through a gas guide pipe. The pump body 1 mainly comprises a pump shell, a balloon and a gas guide pipe and the like. The pump body 1 is composed of two branch circuits which are parallel to each other, the inlet end 230 of the pump is divided into two parts and extends to the two branch circuits, the outlet ends of the two branch circuits are combined together as the outlet end 220 of the whole pump.

[0075] Specifically, the inner radius of the branch pipe cavity is 10 mm, the length is 100 mm, the inner radius of the outlet end 220 and the inlet end 230 is 5 mm, and the length of the whole pump is 160 mm. The thickness of the pump shell is 3 mm, the balloon is a flexible balloon and has good biocompatibility, the maximum inflation radius of the first balloon 111, the third balloon 113, the fourth balloon 211 and the sixth balloon 213 is slightly larger than the inner diameter of the pipe cavity, and the balloons can completely block the pipe cavity after complete inflation. The volume of the second balloon 112 and the fifth balloon 212 can be flexibly selected according to the actual cardiac output information of the fetus 7.

[0076] The sequential balloon pulsatile blood pump for an artificial uterus provided by the application can generate pulsatile blood flow, can adapt to the high heart rate of the fetus 7, does not affect the cardiac afterload balance of the fetus 7 and has the advantages of avoiding umbilical vessel intubation spasm and the like through the arrangement of the first balloon assembly 110 and the second balloon assembly 210.

[0077] The application further provides a sequential balloon pulsatile blood pump system for an artificial uterus, which comprises an artificial uterus 8, an oxygenator 3 and the sequential balloon pulsatile blood pump for an artificial uterus according to any one of the above.

[0078] The artificial uterus 8 is used for accommodating the fetus 7, and the two ends of the conduit 2 of the pump body 1 are respectively the inlet end 230 and the outlet end 220 of blood, and the inlet end 230 is connected in communication with the umbilical artery 231 of the fetus 7.

[0079] The sequential balloon pulsatile system for an artificial uterus provided by the application can generate pulsatile blood flow, can adapt to the high heart rate of the fetus 7, does not affect the cardiac afterload balance of the fetus 7 and has the advantages of avoiding umbilical vessel intubation spasm and the like through the arrangement of the first balloon assembly 110 and the second balloon assembly 210.

[0080] The application provides a control method of a sequential balloon pulsatile blood pump for an artificial uterus, which is applied to the sequential balloon pulsatile blood pump for an artificial uterus.

[0081] 501. The pump body 1 is arranged in the blood flow circuit of the artificial placenta.

[0082] In this step, the blood pump is correctly installed in the blood flow system of the artificial placenta, ensuring that the blood can circulate smoothly under the drive of the pump body 1. According to the design of the artificial placenta and the blood pump, the inlet and outlet of the pump body 1 are connected with the corresponding pipelines of the artificial placenta, forming a complete blood flow circuit.

[0083] 502. The heart blood supply time and blood discharge time are acquired based on the heart acquisition unit 5, and the blood supply time and blood discharge time are sent to the controller 4.

[0084] The activity of the heart of the fetus 7 is monitored in real time through the heart acquisition unit 5, and accurate blood supply and blood discharge time information is acquired. Specifically, the heart acquisition unit 5 can include an electrocardiogram acquisition patch or other devices capable of monitoring the activity of the heart. These devices convert the heart activity data (such as heart rate, heart rhythm, etc.) collected into blood supply time and blood discharge time, and send them to the controller 4. These information can reflect the actual demand of the heart of the fetus 7.

[0085] 503. According to the data provided by the heart acquisition unit 5, the controller 4 adjusts the pulsation frequency, pulsation intensity and pulsation sequence of at least one of the first balloon assembly 110 and the second balloon assembly 210.

[0086] The pulsation parameters of the balloon assembly are accurately adjusted through the controller 4 to simulate the pulsation process of the natural heart and provide stable blood circulation for the fetus 7.

[0087] Specifically, after receiving the data from the heart acquisition unit 5, the controller 4 analyzes and processes it. According to the analysis result, the controller 4 adjusts the pulsation frequency (i.e. the number of pulsations per minute), the pulsation intensity (i.e. the degree of expansion of the balloon each time) and the pulsation sequence (i.e. the coordinated action between the balloon assemblies) of the balloon assembly. These adjustments aim to make the pulsation of the balloon assembly consistent with the activity of the heart of the fetus 7, so as to ensure that the blood can circulate in the artificial uterus 8 in a natural way.

[0088] Further, in one embodiment provided by the application, the step 503 comprises:

[0089] 5031. In the counterpulsation mode, the controller 4 adjusts the pulsation frequency, pulsation intensity and pulsation sequence of the first balloon assembly 110 according to the data provided by the heart acquisition unit 5.

[0090] Specifically, please refer to FIG. 3 to FIG. 4, FIG. 3 shows the principle of blood entering the blood pump in the counterpulsation mode, and FIG. 4 shows the principle of blood discharging from the blood pump in the counterpulsation mode. In the counterpulsation mode, the first balloon 111 and the third balloon 113 act as one-way valves. Before the heart ejects blood, the first balloon 111 deflates to shrink, and at the same time, the third balloon 113 inflates to block the outlet end 220. When the heart ejects blood, the second balloon 112 deflates to shrink, a low pressure is generated in the pump, and blood is sucked into the pump cavity; after the heart ejects blood, the first balloon 111 rapidly inflates to expand, at the same time, the third balloon 113 rapidly deflates to shrink, and the second balloon 112 inflates to expand, the pressure in the pump cavity rises, and blood is discharged from the pump cavity. The above process is one working cycle of the sequential balloon pulsation blood pump in the counterpulsation mode.

[0091] 5032、In the synchronous mode, the controller 4 adjusts the pulsation frequency, pulsation intensity and pulsation sequence of the first balloon assembly 110 and the second balloon assembly 210 respectively according to the data provided by the heart acquisition unit 5.

[0092] Specifically, please refer to FIG. 6 to FIG. 7, FIG. 6 shows the principle of blood entering the first pump cavity 10 and discharging from the second pump cavity 20 in the synchronous mode, and FIG. 7 shows the principle of blood entering the first pump cavity 10 and discharging from the second pump cavity 20 in the synchronous mode. In the synchronous mode, the first balloon 111, the third balloon 113, the fourth balloon 211 and the sixth balloon 213 all act as valves, and the second balloon 112 and the fifth balloon 212 act as blood drivers. In the synchronous mode, the two blood pumps work alternately. When the blood pump starts, before the heart ejects blood, the first balloon 111 rapidly deflates to shrink, at the same time, the third balloon 113 rapidly inflates to expand to block the outlet end 220, and the second balloon 112 deflates to shrink, a low pressure is generated in the pump cavity, and blood is sucked into the first pump cavity 10. Before the second ejection, the fourth balloon 211 rapidly deflates to shrink, at the same time, the sixth balloon 213 rapidly inflates to block the outlet end 220. When the heart ejects blood, the fifth balloon 212 deflates to shrink, and blood is sucked into the second pump cavity 20; at the same time, the third balloon 113 deflates to shrink, and the second balloon 112 inflates to expand, and blood is discharged from the first pump cavity 10. The blood pump enters a stable working state. In the next cardiac cycle, the third balloon 113 and the fourth balloon 211 inflate to expand at the same time, the first balloon 111 and the sixth balloon 213 deflate to shrink at the same time, the second balloon 112 deflates to shrink, the fifth balloon 212 inflates to expand, and the blood entering the pump is sucked into the first pump cavity 10, at the same time, the blood in the second pump cavity 20 is discharged. In the next cardiac cycle, the first balloon 111 and the sixth balloon 213 inflate to expand at the same time, the third balloon 113 and the fourth balloon 211 deflate to shrink at the same time, the fifth balloon 212 deflates to shrink, the second balloon 112 inflates to expand, and the blood entering the pump is sucked into the second pump cavity 20, at the same time, the blood in the first pump cavity 10 is discharged.

[0093] The sequential balloon pulsation method for artificial uterus provided by the application can generate pulsating blood flow, can adapt to high heart rate of the fetus 7, and does not affect the balance of the fetal 7 cardiac afterload, and has advantages such as avoiding umbilical vascular intubation spasm.

[0094] It should be understood that the term "and / or" herein only describes the association relationship of the associated objects, which means that there can be three relationships, for example, A and / or B can represent the following three cases: A exists alone, A and B exist together, and B exists alone, wherein A and B can be singular or plural. In addition, the character " / " herein generally represents that the front and rear associated objects are in an "or" relationship, but can also represent an "and / or" relationship, which can be understood according to the context.

[0095] In the application, "at least one" means one or more, and "a plurality of" means two or more. "At least one of the following" or the like means any combination of these items, including any combination of single item or multiple items. For example, at least one of a, b, or c can represent a, b, c, a-b, a-c, b-c, or a-b-c, wherein a, b, and c can be single or multiple.

[0096] It should be understood that in various embodiments of the application, the size of the sequence number of the above processes does not mean the order of execution, and the execution order of the processes should be determined according to its function and inherent logic, and should not constitute any limitation on the implementation process of the embodiments of the application.

[0097] The above is only a specific implementation of the application, but the protection scope of the application is not limited thereto, and any person skilled in the art can easily think of changes or replacements within the technical range disclosed by the application, which should be covered within the protection scope of the application. Therefore, the protection scope of the application should be subject to the protection scope of the claims.

Claims

1. A sequential balloon pulsating blood pump for an artificial uterus, characterized in that: The blood pump comprises: A pump body, the pump body being arranged in the blood flow circuit of the artificial placenta, the pump body comprising a first pump chamber and a second pump chamber; Wherein, a first airbag assembly is provided in the first pump cavity, and the first airbag assembly includes a first balloon, a second balloon and a third balloon which are arranged in sequence; A second airbag assembly is provided in the second pump chamber, and the second airbag assembly includes a fourth balloon, a fifth balloon and a sixth balloon which are arranged in sequence; The first pump chamber and the second pump chamber are connected in parallel via a catheter, and the two ends of the catheter are respectively a blood inlet and an outlet, the inlet is connected to the fetal umbilical artery, and the outlet is connected to the fetal umbilical vein via an oxygenator; a controller, the controller being in communication with the first airbag assembly and the second airbag assembly respectively; A heart collection unit is provided on the outer surface of the artificial uterus and is in communication with the controller.

2. The sequential balloon pulsating blood pump for an artificial uterus according to claim 1, characterized in that: The volume of the second balloon after expansion is greater than the volume of the first balloon and the third balloon after expansion.

3. The sequential balloon pulsating blood pump for an artificial uterus according to claim 1, characterized in that: The volume of the fifth balloon after expansion is greater than the volume of the fourth balloon and the sixth balloon after expansion.

4. The sequential balloon pulsating blood pump for an artificial uterus according to claim 1, characterized in that: The controller includes a regulating module, which can adjust the beating frequency and beating intensity of the first airbag assembly and the second airbag assembly according to data provided by the heart acquisition unit.

5. The sequential balloon pulsating blood pump for an artificial uterus according to claim 1, characterized in that: A pressure sensor is further provided in the pump body, and the pressure sensor is in communication connection with the controller. The pressure sensor is used to obtain pressure data of the blood in the pump body and send the pressure data to the controller.

6. The sequential balloon pulsating blood pump for an artificial uterus according to claim 1, characterized in that: Both ends of the catheter are provided with connecting joints for detachably connecting to the fetus's umbilical artery and the oxygenator respectively.

7. The sequential balloon pulsating blood pump for an artificial uterus according to claim 1, characterized in that: The pump body further comprises a temperature regulating device, which is disposed in the pump body and is used to regulate the temperature of the blood in the pump body.

8. A sequential balloon pulsation blood pump system for an artificial uterus, characterized in that: comprising an artificial uterus, an oxygenator, and a sequential balloon pulsating blood pump for an artificial uterus according to any one of claims 1 to 7; The artificial uterus is used to accommodate the fetus, and the two ends of the catheter of the pump body are respectively the inlet end and the outlet end of the blood, and the inlet end is connected to the umbilical artery of the fetus.

9. A control method for a sequential balloon pulsating blood pump for an artificial uterus, characterized in that: The sequential balloon pulsating blood pump for an artificial uterus according to any one of claims 1 to 7, wherein the method comprises: The pump body is arranged in the blood flow circuit of the artificial placenta; Acquire the heart blood supply time and blood ejection time based on the heart acquisition unit, and send the blood supply time and blood ejection time to the controller; The controller adjusts the beating frequency, beating intensity and beating sequence of at least one of the first airbag assembly and the second airbag assembly according to the data provided by the cardiac acquisition unit.

10. The control method for a sequential balloon pulsating blood pump for an artificial uterus according to claim 9, characterized in that: The controller adjusts the beating frequency, beating intensity, and beating sequence of at least one of the first airbag assembly and the second airbag assembly according to the data provided by the heart acquisition unit, including: In the counterpulsation mode, the controller adjusts the beating frequency, beating intensity and beating sequence of the first airbag assembly according to the data provided by the cardiac acquisition unit; In the synchronous mode, the controller adjusts the beating frequency, beating intensity and beating sequence of the first airbag assembly and the second airbag assembly respectively according to the data provided by the heart acquisition unit.

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