Time-release capsule

Abstract

The time-release capsule is a new method of producing oral drug capsules that is designed with the main purpose of keeping the blood dose of the drug stable in the body. This capsule is a normal capsule on the surface, but in fact, several smaller capsules are next to each other, each of which opens in the stomach at a different time and releases a certain dose of the drug, as a result of this method, the dose of the drug in the blood remains constant and the side effects of changing the dose are prevented. This capsule can be used in the treatment of addiction withdrawal, people sensitive to dose changes, oral insulins, etc. Used. And of course, another unique feature of this capsule is the possibility of using several drugs in one capsule at the same time, and this feature is independent of whether the drug is solid or liquid. In general, the different ways to benefit from this capsule depend on your needs and creativity.

Description

Time-Release Capsule

[0001] The invention relates to Medicine drugs, Pharmacology and oral medications.

[0002] The invention ahead is a type of medicinal capsules widely used in the pharmaceutical industry, with millions of people using capsules every day for various reasons. These everyday capsules contain medication and a coating of different materials that opens up in the stomach after ingestion, releasing the medication. Of course, daily capsules have their own advantages and disadvantages that can have an impact on the therapeutic process based on the needs of the producer and consumer. Therefore, a suitable solution must be provided for each need. The invention in front of you is a new type of drug capsules that can create new methods in treatment and healthcare services. Different types of capsules have been created over time with different designs and objectives entering the market, each having its own unique disadvantages and of course their own specific solutions as well. This invention has unique features that can solve many problems and introduce new ideas into the pharmaceutical industry.

[0003] This capsule is a capsule with an exterior appearance similar to regular capsules. The main difference of this drug from others lies in its internal structure. Inside this capsule, 4 to 6 spherical capsules are placed. Each spherical capsule has a different wall thickness from other capsules, ranging from very thin to very thick. For example, the second capsule has double the thickness of the first capsule, the third capsule has double the thickness of the second, and so on. The drug of interest is inside all of these spherical capsules, along with a certain amount of compressed air. The reason for the presence of air will be discussed further. All the spherical capsules are placed next to each other inside the main capsule, and within them, there is also the drug.

[0004] The functioning process of this capsule is as follows: After swallowing the capsule and it entering the stomach, like regular capsules, its coating softens and slowly opens. Once the main capsule coating is opened, the drug and spherical capsules are released. The initial dose of the drug is absorbed by the body with the disappearance of the main coating, and its effect begins. The initial dose is the same drugs that had filled the space between the spherical capsules. Next, it is the turn for the spherical capsules to open. As mentioned, inside the spherical capsules, there is both drug and air. The reason for the presence of air in these capsules is to keep them floating on the surface of the stomach acid and prevent them from passing to the small intestine. This way, all the spherical capsules remain in the stomach until they are opened.

[0005] Now it's time for the spherical capsules to open. Different thicknesses used for each capsule cause them to open at different times and release their contents. Initially, the first capsule with less thickness opens and releases its drug. After the first capsule opens and the drug is absorbed, we will observe that the drug dose in the blood remains reasonably constant, not suddenly increasing or decreasing. This process repeats for the subsequent spherical capsules. The timing, number of spherical capsules, and wall thickness are flexible and can be used for drugs three times a day, four times a day, etc. This function ensures that when the last spherical capsule opens, it's time for consumption of the next main capsule. By taking the next capsule, the drug dose in the body remains constant, preventing any sinusoidal effects of drug dose.

[0006] Sometimes, in the use of medicines, the continuation of use and delivery of drugs to the body at a fixed dose is very important. Because if forgetfulness occurs while taking a dose of the drug, the treatment process will be disrupted. On the other hand, by taking one capsule or pill, the dose of the drug in the blood will increase at the initial time, and at the end of the time (until the next capsule is taken again), the dose in the blood will decrease, which means that the effect of the drug will be greater at one time and less at another time, and as a result of this sinusoidal effect, the effectiveness of the drug will decrease.

[0007] In the process of addiction withdrawal, due to the reduction of addictive substances in the blood, the need for using addictive drugs increases. In the path of addiction recovery, sometimes drugs with lower intensity are used to prevent withdrawal symptoms, which, due to the cyclical effect of the drugs on the blood and during consumption, provides more satisfaction to these individuals. However, towards the end of consumption, as the dose decreases, the intense need returns, leading to inappropriate behaviors.

[0008] The exact same issue is also a problem for the oral insulins that scientists are trying to produce, because the effect of insulin is greater at the beginning of the use and less at the end of it, which will cause behavioral and functional disorders.

[0009] On the other hand, sometimes for the treatment of diseases, we need to use multiple medications simultaneously, which can lead to confusion and forgetfulness in drug intake, resulting in disruption of the treatment process.

[0010] The main goal of this invention is to address the issue of sinusoidal effects of consumed doses. By its unique design in the production of oral capsules, this invention will ensure the constant blood dose levels of medications throughout the prescribed period, eliminating high or low mood fluctuations in individuals. This method of capsule production can be utilized in addiction treatment processes, therapeutic treatment of individuals with cognitive impairment, excessive drug sensitivity, multiple medications and, In the not-so-distant future, it can also be employed in the production of oral insulins.

[0011] One solution to all the mentioned problems exists, and that is maintaining a steady level of medication in the bloodstream. By reducing these sinusoidal changes, many problems can be solved to a great extent. By dividing the compositions inside the capsule and releasing each part gradually, this goal can be achieved. In this method, we will benefit from the capsule in the capsule process, where a large capsule serves as the main reservoir, accommodating the initial dose along with smaller capsules. The smaller capsules also have different walls, each with unique thickness and material to release the dose at the appropriate and predicted time. This simple method can solve several problems and, in addition, can generate new ideas for producing and delivering drugs in a different and more profitable way.

[0012] A) Maintaining a steady dosage of medication in patients for the duration prescribed by the physician.

[0013] B) Assisting in drug addiction withdrawal for addicted patients by reducing the dosage of narcotics, maintaining their essential need for the medication, thereby reducing cravings and dependency on drugs.

[0014] C) Minimizing the effects of dose alterations in blood levels of medications in sensitive and at-risk individuals by reducing sinusoidal fluctuations in drug dosages.

[0015] D) Utilization in future therapeutic methods for diabetes with oral insulin.

[0016] E) Simple manufacturing method with low production costs yielding highly valuable and efficient results.

[0017] F) possibility to enjoyment of multiple drugs in one capsule.

[0018] The drawn images illustrate the overall structure of this invention and the subsequent stages after ingestion. By examining these images, a precise design of this invention, its functioning method, and its specific features can be understood. Four images have been designed for further insight; in images one and two, the structure of this invention can be observed, while in images three and four, the operation of this invention is visible.Fig.1

[0019] - An overview of the capsule structure reveals a large capsule containing smaller capsules within.

[0020] - An image of the small capsules arranged in order of wall thickness is displayed.

[0021] - A general view of the large capsule opening in the stomach immediately after ingestion is shown. In this image, the release of the initial dose and smaller capsules can be observed.

[0022] Fig.4 - A view from inside the stomach shows the floating of the small capsules, demonstrating the sequence of opening based on wall thickness and material.

[0023] In Figure one, you can see an overall view of the main structure of this invention. A large capsule that resembles ordinary capsules, divided into two essential parts inside. The first part is the initial dose medication spread throughout the capsule (3), and the second part is small capsules placed inside the main capsule in a specific quantity (1 and 2). The dosage amount of the drug in each of the small capsules is equal. Inside each of the small capsules, there is a certain amount of compressed air along with the drug, forming the contents of the capsules. This compressed air causes these capsules to float on the stomach acid and not enter the small intestine. The thickness of the walls of the capsules varies from each other, and this difference in thickness and material causes each capsule to open at different times, preventing the sudden entry of the drug dose into the bloodstream.

[0024] Figure number two shows the thickness of the walls of small capsules. On one side, there is a capsule with a strong and thick wall, while on the other side, there is a capsule with a weak and thin wall. The important feature is that each of these capsules can be filled with a different drug, which is very specific and effective in its own way.

[0025] Shape number three is the process of opening the main capsule. By consuming the capsule, initially, the main wall is opened, and the initial dose of the drug along with small capsules are released. In this shape, you can observe this process well.

[0026] In Figure number four, the process of opening small capsules is also shown. Each of these capsules opens at different times and releases their contents. As you can see, the capsule first becomes thin-walled, and eventually, the capsule with a thick wall will open.Examples

[0027] Generally, capsules are made from various materials, including soft gelatin capsules that dissolve quickly and hard gelatin capsules. This invention combines soft and hard capsule structures, focusing on the stomach acid tolerance time for opening. The main shell utilizes a soft gelatin structure that starts to open upon entering the stomach, releasing its contents. On the other hand, spherical capsules use a harder material, with different thicknesses for each capsule determining the amount of digestible plastic in them. Thinner walls have more gelatin to plastic ratio, while thicker walls have more digestible plastic to ensure longer dissolution time and prevent rapid opening. These capsules can hold various drugs and are versatile depending on the medication and manufacturer, with varying numbers of spherical capsules used accordingly.

[0028] This capsule has the potential to be used with a wide range of oral medications, making it suitable for use in both public and private sectors of the pharmaceutical industry. By addressing a significant market need in various countries, mass production of this product is anticipated. Due to the constant and high consumption of oral medications for various diseases and the unique characteristics of this product, reaching global markets is not far-fetched.

[0029] U.S. PATENT DOCUMENTS :

[0030] 4,792,451 20 / 1988 Kim

[0031] US 2020 / 0155466 A1 21 / 2020 Houtz, II

[0032] US 2017 / 0292011 A1 12 / 2017 WATANABE et al.

[0033] US 8,413,968 B2 9 / 2013 AI-Anzi

Claims

This medication consists of a large main capsule with a normal coating and several spherical capsules inside it, each containing medication, with no connection between them and being independent of each other.Based on claim number 1, each of the spherical capsules has varying wall thickness, ranging from thin to thick.According to claim number 1, there is medication inside the main capsule and between the spherical capsules.According to claim number 2, the spherical capsules contain both medication and air.According to claim number 1, the main capsule has lower resistance to stomach acid compared to the spherical capsules.

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