High molecular weight polymers and methods of making the same
Copolymers with mucoadhesive monomers and backbone residues address the limitations of synthetic mucins by mimicking natural mucins, improving intestinal barrier integrity and reducing bacterial translocation.
WO2025250734A1PCT designated stage Publication Date: 2025-12-04UNIV OF FLORIDA RESEARCH FOUNDATION INC +1
Patent Information
- Application Number
- PCT/US2025/031337
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-05-29
- Filing Date
- 2025-05-29
- Publication Date
- 2025-12-04
AI Technical Summary
Technical Problem
Existing synthetic mucins fail to replicate the intricate properties of natural mucins, leading to compromised intestinal barriers and increased susceptibility to infections and inflammation.
Method used
Development of copolymers comprising mucoadhesive monomers with specific residues, such as boronic acid, carboxylic acid, and amines, and backbone monomers like acrylamides, synthesized through UV irradiation and inert gas sparging to achieve molecular weights similar to natural mucins.
Benefits of technology
The copolymers mimic natural mucins, enhancing intestinal barrier function and reducing bacterial translocation, thereby ameliorating gastrointestinal disorders.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure US2025031337_04122025_PF_FP_ABST
Abstract
In one aspect, the disclosure relates to relates to copolymer compounds that include mucoadhesive monomers and methods of making the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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Citation Information
Patent Citations
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