Electrical stimulation device for cortical evoked potential capable of acquiring electrical stimulation sequence on the basis of task

Abstract

An electrical stimulation device for a cortical evoked potential capable of acquiring an electrical stimulation sequence on the basis of a task. Different channel sets related to a plurality of functions are constructed and sorted, that is, channels in any channel set that have not undergone electrical stimulation acquire alternative values of the channel sets on the basis of task-related electroencephalogram activation levels, and the alternative values corresponding to different channel sets are sorted to obtain a sequence of the channel sets; channels are sorted on the basis of the task-related electroencephalogram activation levels; and the order of the sorted channels is used as a preset electrical stimulation sequence for a cortical evoked potential. The device can characterize the relevance of channels across different functional areas, and can indicate the importance of the channels in the functional areas, such that a doctor is guided more objectively to obtain more useful electrical stimulation data within a shorter surgical time, so as to determine whether the positions of the channels affect functions and whether resection is allowed.

Description

Electrical stimulation device for obtaining cortical intercortical evoked potentials based on task acquisition of electrical stimulation sequences TECHNICAL FIELD

[0001] The present application belongs to the technical field of physiological electrical signal processing, and particularly relates to an electrical stimulation device for obtaining cortical intercortical evoked potentials based on task acquisition of electrical stimulation sequences. BACKGROUND

[0002] Cortical-cortical evoked potentials (CCEP, referred to as intercortical evoked potentials) can verify the coverage area of an epileptogenic network, especially in lesionectomy surgery to avoid cutting brain tissue that has an impact on function in the functional area. Doctors generally traverse each pair of adjacent electrodes (corresponding to the channels in the present case) on the electrode sheet and apply electrical current stimulation a plurality of times to obtain overall results to determine the relationship between the stimulation site (cortex) and the recording site (cortex). The specific stimulation scheme is as follows: for example, a single pulse stimulation of 10 mA is used, and the number of repetitions is 20. Step 1: apply electrical current to stimulate a certain electrode (pair) on the cortical electrode sheet; Step 2: record the signals of the electrodes on the cortical electrode sheet; Step 3: superimpose and average the waveforms stimulated multiple times for each electrode; Step 4: calculate the Z-score for the superimposed and averaged waveforms of each electrode on the cortical electrode sheet; Step 5: display the network formed by the electrodes with a Z-score > 6 and the stimulation electrode; Step 6: apply electrical current to stimulate other electrodes (pairs) on the cortical electrode sheet, and repeat steps 1 to 5, and display the different networks in the results on the same brain model in different colors to form a brain network.

[0003] Doctors are more desirous of quickly obtaining the electrical stimulation results of the part of interest in a short time to facilitate subsequent surgery. However, in the intraoperative scenario, time is tight, and it is difficult to traverse each pair of adjacent electrodes on the electrode sheet. Therefore, it is particularly important to preset the electrical stimulation sequence according to the surgical requirements before surgery or to adaptively adjust the electrical stimulation sequence according to the surgical progress during surgery.

[0004] As patent number CN104978035B based on somatosensory electric stimulation induced P300 brain-computer interface system and its implementation method, it is disclosed that the different positions on the surface of the human body are encoded to generate an electric stimulation sequence, and the array type electric stimulation electrode is controlled to output electric stimulation according to the electric stimulation sequence. The electric stimulation is transmitted to different positions on the human body via the array type electric stimulation electrode. Although the method relates to the setting method of the electric stimulation sequence, it does not mention the problem of stimulation artifact. For example, in paragraph 0049, the electric stimulation intensity is 1.4±0.1mA, and the duration is 1ms. The stimulation coding sequence has 4, each sequence includes 6 rounds, each round has 4 trials, the stimulation interval is 800ms, the stimulation sequence is random, and before the stimulation starts, the user pays attention to the target stimulation as required, such as A, then the user pays attention to the electric stimulation transmitted to the little finger of the left hand, and ignores the stimulation of the other three fingers. A, B, C, D four types each act as a target stimulation. The main reason is that the electric stimulation is transmitted to different positions on the human body via the array type electric stimulation electrode, and the different parts of the human body include the hands, feet, upper limbs, lower limbs, and other parts of the body trunk. But these parts are far away, there is basically no functional correlation, and there is no need to determine the importance of the channel position of the brain electric activation for task execution, so it is difficult for this kind of stimulation sequence setting method to be applicable to small range of intercortical evoked electricity, especially in lesion resection surgery. Through the channel position to determine whether the important part in the brain function area is allowed to be resected. SUMMARY

[0005] The application provides a method for obtaining an electric stimulation sequence based on a task, and an intercortical evoked electric stimulation device.

[0006] To solve the above technical problems, the embodiment provides a method for obtaining an electric stimulation sequence based on a task, which comprises: constructing a functionally related channel set; sorting the channels according to the brain electric activation of the task; and taking the sorted channel order as a preset electric stimulation sequence of intercortical evoked electricity.

[0007] Further, the channel sorting further comprises: the physical distance of the channel from the lesion area, that is, the same functionally related channel set is sequentially sorted into a second channel subset> a third channel subset> a first channel subset according to the inside, boundary and outside of the lesion area.

[0008] Further, the acquisition method of the brain electric activation comprises: dividing the brain electric signal segment, that is, dividing the brain electric signal segment corresponding to the task time into a baseline segment and a task segment according to the start node of the set task; acquiring data characteristics, that is, calculating the data characteristics of the baseline segment and the task segment respectively; verifying the difference degree of the distribution constituted by the data characteristics of the task segment and the baseline segment, forming a verification matrix with dimensions representing the channel and the task time respectively, to represent the brain electric activation of each channel when performing the same task.

[0009] Further, the method further comprises: when multiple function-related different channel sets are set, ranking the channel sets.

[0010] Further, the channel set ranking comprises: obtaining a candidate value of a channel set according to the brain electrical activation degree of a channel in any channel set which does not perform electrical stimulation; and ranking the candidate values corresponding to different channel sets to obtain a sequence of the channel set.

[0011] Further, the constructing multiple function-related different channel sets comprises: obtaining any function-related initial channel set; comparing multiple function-related initial channel sets; and channel duplication avoidance, that is, selecting one of the repeated channels into the initial channel set to obtain multiple function-related different channel sets, so that there is no repeated channel between the channel sets.

[0012] Further, the method further comprises adjusting the preset electrical stimulation sequence according to the stimulation artifact state of the channel after electrical stimulation; and the adjusting the preset electrical stimulation sequence comprises: step S1, selecting an electrical stimulation channel to perform initial electrical stimulation; step S2, detecting whether the channels in each channel set meet the stimulation artifact state requirement in sequence according to the channel set ranking; if the requirement is met, selecting the channel in the channel set to perform electrical stimulation according to the channel ranking; if the requirement is not met, leaving it empty; and repeating step S2 until the channel reaches the set electrical stimulation number.

[0013] In a second aspect, the present application provides an electrical stimulation device for intercortical evoked potential, comprising: a processor for executing the steps of the method to obtain a preset electrical stimulation sequence for intercortical evoked potential; a human-computer interaction module for setting the electrical stimulation sequence for intercortical evoked potential; and an electrical stimulation module for performing electrical stimulation on the corresponding channel through an electrical stimulation switch.

[0014] Further, the method further comprises a surgical progress evaluation module for evaluating the electrical stimulation progress according to the brain electrical activation degree of the channel which does not perform electrical stimulation; and a prompt module for prompting the channel to perform the next electrical stimulation.

[0015] In a third aspect, the present embodiment provides a computer device comprising a memory, a processor, and a computer program stored in the memory, wherein the processor executes the computer program to implement the steps of the method.

[0016] In a fourth aspect, the present embodiment provides a computer readable storage medium having a computer program stored thereon, wherein the computer program is executed by a processor to implement the steps of the method.

[0017] In a fifth aspect, the present embodiment provides a computer program product comprising a computer program, wherein the computer program is executed by a processor to implement the steps of the method.

[0018] The beneficial effects of the present application are that the electric stimulation device of the present application first establishes a function-related channel set, and then sorts the channels in the channel set according to the brain electrical activation degree of performing a task; the sorted channel sequence is used as a preset electric stimulation sequence before surgery. The electric stimulation sequence of the channel formed by the brain electrical activation degree of performing a task can show the importance of the channel in the functional area, and more objectively guide the doctor to obtain more useful electric stimulation data in a shorter surgery time to determine whether the position of the channel affects the function and whether it is allowed to be resected.

[0019] Other features and advantages of the present application will be set forth in the following description, and in part will become apparent to those skilled in the art from the description, or can be learned by practice of the present application. The objects and other advantages of the present application will be realized and achieved by the structure particularly pointed out in the description, claims and drawings.

[0020] In order to make the above-mentioned objects, features and advantages of the present application more obvious and easy to understand, the following preferred embodiments are specifically described below, and the accompanying drawings are described in detail as follows. BRIEF DESCRIPTION OF DRAWINGS

[0021] In order to more clearly illustrate the specific embodiments of the present application or the technical solutions in the prior art, the following will briefly introduce the drawings needed to be used in the specific embodiments or the prior art description. Obviously, the drawings in the following description are provided by some embodiments, and for those skilled in the art, other drawings can also be obtained without creative labor on the basis of these drawings.

[0022] Fig. 1 is a flowchart of a single-function acquisition electric stimulation sequence provided by some embodiments;

[0023] Fig. 2 is a flowchart of a multi-function acquisition electric stimulation sequence provided by some embodiments;

[0024] Fig. 3 is a CCEP waveform diagram of stimulation electrode i when other stimulation electrodes perform electric stimulation provided by some embodiments;

[0025] Fig. 4 is a CCEP waveform diagram of stimulation electrode j when other stimulation electrodes perform electric stimulation provided by some embodiments;

[0026] Fig. 5 is a position schematic diagram of lesion area electrode sorting provided by some embodiments;

[0027] Fig. 6 is a principle block diagram of an electric stimulation device provided by some embodiments;

[0028] In Fig. 5: electrode sheet 1, first channel subset 11, second channel subset 12, third channel subset 13; lesion area 2. DETAILED DESCRIPTION

[0029] In order to make the purposes, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the present application will be described clearly and completely below with reference to the drawings. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the scope of the present application.

[0030] In the epilepsy lesion resection surgery, the brain function area can be located by existing means such as diffusion tensor imaging (DTI), electrical stimulation (ESM), online spatial-temporal functional mapping, and then the epileptogenic network or the brain tissue having influence on function in the functional area to be avoided from being mistakenly cut can be studied by the cortical-cortical evoked potential (CCEP, referred to as intercortical evoked potential). However, how to determine the electrical stimulation sequence of the channel (also referred to as electrode in the present case) in the intercortical evoked potential has not been unified, and often depends on the experience of the doctor himself. As described above, in order to avoid mistaken cutting, all electrodes on the electrical stimulation electrode sheet are generally traversed. In view of this, as shown in FIGS. 1-5, the present embodiment further provides a method for obtaining an electrical stimulation sequence based on a task, to obtain a preset electrical stimulation sequence of the intercortical evoked potential. Specifically, it comprises: constructing a channel set related to a function; sorting the channels according to the brain electrical activation of the task; and taking the sorted channel sequence as the preset electrical stimulation sequence of the intercortical evoked potential. Generally, a single function-related channel has only one channel set by default, and a channel set can be determined by performing a task, and then the channels in the channel set can be sorted according to the brain electrical activation of the task, which can be forward sorting or reverse sorting, to determine the most important or most relevant channel in the function, and the electrical stimulation is performed preferentially; the essence is to comprehensively consider the dual combination of function importance and channel importance. In actual operation, the operation time can also be set according to the preset electrical stimulation sequence, or in the process of operation, the electrical stimulation of a function-related channel can be terminated at any time according to the brain electrical activation.

[0031] In some optional embodiments, the channel sorting comprises: sorting the brain electrical activation of each channel in the same channel set when performing the same task, to obtain a sequence of the corresponding channel. For example, the channel sorting of the channel set A related to function A is set as A1>A2>A3>A n , the first electrical stimulation A1 is performed on the channel A1, and the second electrical stimulation A1 is preferentially performed on the channel A1 according to the channel sorting, rather than on the channel A2 or the channel A3 or the channel A nThe first electric stimulation is performed on the channel Al, and only when the number of times of performing the electric stimulation Al on the channel Al reaches the set number of times of electric stimulation, the first electric stimulation A2 is performed on the channel A2. In this way, the key channel related to the function is ensured to complete the electric stimulation first, and the effectiveness of the electric stimulation data in determining whether to remove the function-related part is ensured.

[0032] Generally, the doctor pays more attention to the brain tissue near the lesion responsible for what function, so as to confirm whether to remove part of the current non-serious brain tissue in combination with the results of the intercortical induced electric stimulation to prevent postoperative recurrence. Therefore, on the basis of the foregoing sorting, the channels can also be sorted according to the physical distance of the channels from the lesion area, or separately, based on the physical distance of the channels from the lesion area, the lesion area is taken as the center to diverge, the lesion center or the range where the lesion exists is first determined, and then the physical distance of each channel to the lesion center is calculated to generate an electric stimulation sequence from near to far. Specifically, as shown in FIG. 5, the lesion area 2 is covered by the electrode sheet 1, and the same task-related channel set is divided into a first channel subset 11, a second channel subset 12, and a third channel subset 13 according to the inside, the boundary, and the outside of the lesion area. Since the channels falling within the lesion area are considered to have a negative distance from the lesion, they do not participate in the electric stimulation, which can save the operation time, and therefore the sorting standard is configured as the second channel subset > the third channel subset > the first channel subset, and then the channels in each channel subset are sorted according to the distance from the lesion area or the brain electric activation of the task.

[0033] Some optional embodiments of the brain electric activation of the task.

[0034] The acquisition method of the brain electric activation of the task includes: dividing the brain electric signal segment, that is, dividing the brain electric signal segment corresponding to the task time into a baseline segment and a task segment according to the start node of the set task; acquiring data features, that is, calculating the data features of the baseline segment and the task segment respectively; verifying the difference degree of the distribution constituted by the data features of the task segment and the baseline segment to form a verification matrix with dimensions representing the channels and the task time respectively, so as to represent the brain electric activation of each channel when performing the same task.

[0035] In some embodiments, the set task is configured as at least one of an initial electric stimulation, a preset task, and a historical task. Preferably, the channel position of the initial electric stimulation is configured as outside the lesion area and close to the boundary between the lesion area and the functional area, which can be the brain tissue closest to the lesion center and must be determined whether to remove.

[0036] In some embodiments, in the present case, the channel's electroencephalogram activation degree is, for example but not limited to, high gamma activation degree. First, the doctor performs time-domain and space-domain online high-frequency brain function area positioning for the patient, and obtains the high gamma activation degree ranking of the electrodes, which is used as the stimulation sequence of CCEP. Since high gamma and CCEP itself have multiplexing phenomenon on the device, and the two have similar effects (it can be intuitively understood that the channels with high gamma activation degree ranking in the front are also the parts that need to be focused on by the doctor in CCEP), each has advantages and disadvantages in details, therefore, the high gamma activation degree is used to guide the stimulation sequence of the functional positioning results, and the weighted results of the two are closer to the gold standard ESM, and the long task requirements are also avoided. Since the channels are judged by task correlation whether they need to be electrically stimulated, only some electrode pairs are stimulated or the CCEP process is terminated in advance, which saves the operation time and also obtains the position results that the doctor is more concerned about.

[0037] Of course, the high gamma activation degree ranking can also be the high gamma result under known conditions, which can be the result of the task performed on each stimulation electrode, or it can be the doctor's experience-based judgment. For example, patent number CN117952195A - brain network construction method based on task-related electroencephalogram activation degree and display device discloses a construction method of a test matrix, which represents the electroencephalogram activation degree of each channel in the task time through the test matrix or the spatial matrix obtained therefrom.

[0038] FIG. 2 is a flowchart of a multifunctional acquisition of an electrical stimulation sequence according to some embodiments.

[0039] As an optional implementation of the multi-channel set ranking.

[0040] First, a plurality of functionally related different channel sets are constructed, including: acquiring any functionally related initial channel set; comparing a plurality of functionally related initial channel sets; channel duplication avoidance, that is, repeatedly including the channel in the initial channel set according to the electroencephalogram activation degree of the channel in performing different functionally related brain functions, to obtain a plurality of functionally related channel sets, so that there is no repeated channel between the channel sets.

[0041] Optionally, the initial channel set of any function correlation can be obtained preoperatively by various brain function localization techniques, such as by means of diffusion tensor imaging (DTI), electrical stimulation (ESM), online spatial-temporal functional mapping, cortical-cortical evoked potential (CCEP, referred to as intercortical evoked potential), etc. to locate the brain function area, and then different electrical stimulation channels are regarded as or divided into the initial channel set of the same function correlation according to the brain function area or function correlation, as shown in Table 1.

[0042] Table 1 Comparison of various existing localization techniques

[0043] Of course, the initial channel set of the same function correlation can also be deleted or increased by doctor's experience setting (such as desired attention position, lesion area or lesion adjacent area, etc.) or other ways (such as known brain function) to obtain multiple channel sets of different function correlations. In addition, the initial channel set of function correlation can also be obtained during intraoperative electrical stimulation, that is, the electroencephalogram activation of each channel is obtained by initial electrical stimulation, and the function correlation of the channel is obtained by using the electroencephalogram activation, or the channel set is formed in combination with the function area where the channel is located. In the actual surgical process, the electroencephalogram activation of all channels is not necessarily obtained by initial electrical stimulation, and the doctor usually stimulates a series or part of points and lets the patient do a simple task (such as counting) at the same time to obtain the initial effective electrical stimulation result and the corresponding electroencephalogram activation.

[0044] Secondly, since the intercortical evoked potential is a repeated electrical stimulation on the channel without the need to do the task, the initial channel set of different function correlations obtained often has repeated channels, and is not suitable for intercortical evoked electrical stimulation. Therefore, further processing of the initial channel set is required, and the channel set of different function correlations is first determined and it is ensured that there is no repeated channel in each channel set. In the actual processing process, there are various methods for avoiding channel repetition, for example, the upward comparison method can be used for the initial channel set of different function correlations in the order of channel set. First, the initial channel set A' of function A connection is obtained = {A1, A2, A3,.. A n}, the initial channel set B' of function B connection is obtained = {B1, B2, B3..B m}, and the initial channel set C' of function C connection is obtained = {C1, C2, C3,..C x} and set the ordering of the channel sets as initial channel set A' > initial channel set B' > initial channel set C'. In the comparison of multiple function-related initial channel sets, for example, in a pairwise comparison manner, taking initial channel set A' as the reference, assuming that channel A1 is repeated with channel B2, the difference set of initial channel set B' and initial channel set A' is taken (if there are repeated channels, they can be placed in channel set A or channel set B), and the channel set A associated with function A is obtained as A = {A1, A2, A3,..A n} and the channel set B associated with function B is obtained as B = {B1, B3,..B m} ; assuming that channel C1 is repeated with channel A1 and channel C2 is repeated with channel B1, the difference set of initial channel set C' and the union of initial channel set A' and initial channel set B' is taken, and the channel set C associated with function C is obtained as C = {C3,..C x} ; and so on, to construct all function-related channel sets. If the difference set of initial channel set C' and the union of initial channel set A' and initial channel set B' is zero, the channels associated with function C are respectively included in other channel sets or as channel set C, and the repeated channels in other channel sets need to be deleted. Alternatively, all the function-related multiple channel sets can be compared, and the initial channel sets can be divided into single-function channel subsets (i.e., channel sets related to only a single function) and multi-function channel subsets (i.e., channel sets related to multiple functions, which belong to the repeated channels in the pairwise comparison) according to the function-relatedness of the channels. The single-function channel subsets are sorted according to the channel set ordering to form a sequence of channel sets, and the multi-function channel subsets are selected to be included in the corresponding single-function channel subsets (belonging to the same channel set). For example, initial channel set A' is divided into single-function channel subset A'' = {A1, A2, A3} and multi-function channel subset A''' = {A4, A5,..A n} ; initial channel set B' is divided into single-function channel subset B'' = {B1, B2, B3} and multi-function channel subset B''' = {B4, B5,..B n} ; and initial channel set C' is divided into single-function channel subset C'' = {C1, C2, C3} and multi-function channel subset C''' = {C4, C5,..C nThen, the single-function channel subsets A", B", and C" are sorted into channel sets, and the repeated channels in the multi-function channel subsets A"', B"', and C"' are selected into the corresponding channel sets (i.e., the multi-function channel subsets belong to the same initial channel set as the single-function channel subsets). For example, the single-function channel subset A" is included in channel set A, the single-function channel subset B" is included in channel set B, and the repeated channels in the multi-function channel subsets B" and A" are included in channel set A or channel set B. If the multi-function channel subsets do not have corresponding single-function channel subsets, the function-related channel sets can be independently set by comparison. For the channels in the multi-function channel subsets, the channels can be classified into the function-related channel sets or independently set in the function-related channel sets according to the functions corresponding to the highest brain electrical activity values of the channels in performing different tasks.

[0045] Finally, when multiple function-related channel sets are set, the channel sets are sorted. The sorting of the channel sets includes obtaining a candidate value of a channel set for a channel that does not perform electrical stimulation according to the brain electrical activity of the task, such as but not limited to the proportion of the number of channels that do not perform electrical stimulation in the same function-related channel set or the maximum value of the brain electrical activity of the channel that does not perform electrical stimulation when performing the same task. The candidate values of different channel sets are sorted to obtain the sequence of the channel sets.

[0046] When the operation time is sufficient, each channel will eventually be repeated to the set number of electrical stimulations, but when the operation time is relatively tight or temporarily interrupted, the overall operation progress or the determination of the need to remove brain tissue in each function-related area needs to be considered, and therefore the channel set that needs to be preferentially performed can be adjusted according to the channels that do not perform electrical stimulation. For example, the brain electrical activity of the channel that does not perform electrical stimulation is relatively high, which indicates that the important tissue in the function area has not been confirmed whether it can be removed, and needs to be preferentially confirmed. For another example, the proportion of the number of channels that do not perform electrical stimulation in the same function-related channel set is relatively high, which indicates that the progress of the tissue removal operation in the function area is relatively slow, and also needs to be preferentially processed, so as to ensure that each function area can meet the basic removal requirements to meet the lesion removal requirements.

[0047] Generally, before the operation, the doctor will sort the channel set according to the purpose of the operation or the importance of the functional area, so that the more important brain function area can be located first during the operation. Since the task is set according to the required function to determine whether the function is allowed to be removed at the electrode position, and since it is not possible to verify whether the position is also related to other functions, generally only the electrodes and the positions near the electrodes that cannot be removed are verified for the results of the electrical stimulation. Although individuals are different, the approximate range of brain function areas is basically determined. For example, the purpose of the task is to determine the non-removable part related to the language function, and the channel position related to the task will mostly fall into the language function area, and it is also possible to fall into the motor imagination function area. At this time, the channel located in the language function area is preferentially selected when doing electrical stimulation, because the channel is theoretically more related to the language function. Therefore, in addition to considering the brain electrical activation of the channel that has not been subjected to electrical stimulation, the criteria for the channel set sorting also include, but are not limited to, the importance of the functional area, the core area of interest of the doctor, the physical distance of the channel position from the center of the lesion, the functional area where the channel position is located, the number of channels participating in stimulation or the channel ratio, and the specified rules. It is usually related to the physical position and number of channels on the electrode sheet, and can be a common sequence such as clockwise, counterclockwise, row sequence, column sequence, etc. Before the stimulation starts, the doctor manually sets the number of channels participating in the stimulation or the channel ratio, and can also specify a rule so that part of the channels do not participate in the electrical stimulation, forming a specific channel set sorting scheme. No matter which scheme is selected, the actual operation time will be shortened.

[0048] In addition, the electrical stimulation sequence of the channels is set by using a multi-level sorting method in combination with the function-related channels, and a preset electrical stimulation sequence is generated. The priority of the channels performing electrical stimulation by default is channel set sorting>channel sorting, but the priority is not absolutely related, and the priority of any sorting can be closed or adjusted by the man-machine interaction module before or during the operation. Of course, during the electrical stimulation process, the doctor can also manually stop the electrical stimulation of any channel according to the function or task-related channel situation, only obtain the results of the channels that have already performed electrical stimulation, and further reduce the operation time.

[0049] In summary, in the present case, the associated channels corresponding to the function are first determined by the same function, the channel set sorting is formed according to the maximum value of the brain electrical activation of different tasks, the channel sorting is formed according to the brain electrical activation of the same task, the electrical stimulation sequence of the channels in each channel set is determined, and finally the preset electrical stimulation sequence of the intercortical evoked potential is formed.

[0050] As an optional implementation of adjusting the preset electrical stimulation sequence.

[0051] In the intercortical evoked potential, the electrical stimulation often needs to be repeatedly performed on a certain channel (such as 20 times of repeated operation). After the electrical stimulation is performed on a certain channel, because there are different degrees of stimulation artifacts on the channel and other channels functionally associated with the channel (which can belong to the same channel set or belong to different channel sets), because the effective component of the observed post-stimulation signal has a short duration and a weak amplitude, and the stimulation artifact has a long duration, a strong degree and a large amplitude, the stimulation artifact has a great influence on the overall signal. At the same time, there is no effective stimulation artifact removal method, such as it is difficult to fit the stimulation artifact by grasping the law of the stimulation artifact or it is difficult to remove the stimulation artifact without affecting the effective component to be observed after the stimulation. If the electrical stimulation is continued, it will affect the judgment of the intercortical evoked potential signal on the brain function area, and it is easy to cause misjudgment, so generally the next stimulation cannot be performed until the stimulation artifact is eliminated, and then the effective component after the next stimulation is observed and obtained. For example, stimulating electrode 1 and repeating 20 times of electrical stimulation, waiting for the stimulation artifact to be eliminated; stimulating electrode 2 and repeating 20 times of electrical stimulation, waiting for the stimulation artifact to be eliminated; stimulating electrode 3 and repeating 20 times of electrical stimulation, waiting for the stimulation artifact to be eliminated; stimulating electrode 4 and repeating 20 times of electrical stimulation, waiting for the stimulation artifact to be eliminated……, which seriously wastes the operation time.

[0052] Therefore, the preset electrical stimulation sequence can be adjusted according to the stimulation artifact state of the channel after the electrical stimulation. Specifically, the adjustment of the preset electrical stimulation sequence comprises: step S1, selecting an electrical stimulation channel to perform initial electrical stimulation; step S2, detecting whether the channel in each channel set meets the stimulation artifact state requirement in turn according to the channel set order; if the requirement is met, selecting the channel in the channel set to perform electrical stimulation according to the channel order; if the requirement is not met, leaving it empty; repeating step S2 until the channel reaches the set electrical stimulation number.

[0053] Optionally, the stimulation artifact state comprises at least one of a stimulation artifact duration and a stimulation artifact intensity.

[0054] In the case, the stimulation artifact duration and the stimulation artifact intensity are generally set according to the threshold value of the experience value of the electrical stimulation, which can be single or combined as the detection standard of the stimulation artifact state. For example, it can be compared whether the baseline of the current signal is regressed to the baseline level in the known state without stimulation. Similarly, using indicators such as mean, volatility, difference between maximum value and minimum value, frequency spectrum, etc. can also be similarly achieved. In particular, the stimulation artifact in CCEP is generated by hardware (related devices for applying stimulation current on the stimulator), so the duration is usually fixed, and the guide value of the stimulation artifact duration can also be measured before the production of the device, which usually does not change in the clinical scene.

[0055] For example, see FIG. 3 and FIG. 4 (the horizontal axis direction is the time dimension, and the vertical axis direction is the waveform amplitude), by known conditions, it can be determined that the CCEP waveforms of stimulation electrodes i (which can be understood as a single-channel electrode or a certain channel in a multi-channel electrode) and stimulation electrodes j are not at the same time in the time dimension when other stimulation electrodes perform the same electrical stimulation, and the stimulation artifact between the two will not cross-influence the data processing results. Therefore, it can be considered to alternately perform electrical stimulation on stimulation electrodes i and stimulation electrodes j and repeat 20 times to save the time waiting for the stimulation artifact to be eliminated. Specifically, when other stimulation electrodes perform electrical stimulation, if the waveforms (i.e., CCEP waveforms) induced by the two stimulation electrode pairs (assuming that the electrodes appear in pairs, one positive and one negative) are linearly related in the time dimension, i.e., the time difference between the two waveforms after the nth stimulation is still equal to the time difference between the two waveforms after the first stimulation. The results will not affect each other because the CCEP waveform can be considered to be fixed to appear in a certain period of time after stimulation, and the shape of the wave is also basically fixed. Therefore, as long as the CCEP waveforms of the two electrodes are not at the same time in the time dimension, but have a sequence, it can be determined according to the time when the CCEP waveform appears after stimulation which pair of electrodes induced the waveform, and the stimulation artifact will not affect the processing and judgment of the CCEP waveform. If the duration of the stimulation artifact is greater than the time interval of the alternately performed electrical stimulation between different electrodes, then whether to continue waiting for the time or to allow more CCEP waveforms of electrodes that are not at the same time in the time dimension to cross-stimulate can be determined by the intensity threshold of the stimulation artifact, so that the time interval of the alternately performed electrical stimulation is not less than the time waiting for the stimulation artifact to be eliminated.

[0056] For example, the duration of the stimulation artifact is used as the detection standard of the stimulation artifact state. Take the channel set A related to function A as the reference, perform the first electrical stimulation A1 on channel A1; since all channels in the channel set A are associated with function A, it can be determined that all channels in the channel set A have stimulation artifact A1 caused by electrical stimulation A1 at the same time, and the CCEP waveforms of the channels in the channel set A are at the same time in the time dimension, which does not meet the stimulation artifact state requirement. If the channel set B related to function B contains a single-function channel subset B", since the single-function channel subset B" is not related to function A, it is assumed that the CCEP waveforms of the channels in the channel set A and the single-function channel subset B" are not at the same time in the time dimension. At this time, after cross-performing electrical stimulation B1 on channel B1 in the single-function channel subset B", wait for the time interval of the cross-performed electrical stimulation to be greater than the duration of the stimulation artifact A1, and then perform the second electrical stimulation A1 on channel A1. When the number of electrical stimulation A1 performed on channel A1 reaches the set number of electrical stimulation, perform the first electrical stimulation A2 on channel A2.

[0057] Of course, if the multi-functional channel subset B"'is contained in the channel set B related to function B, for example, there is a channel in the multi-functional channel subset B"'which is related to both function A and function B, but because the brain electrical activation of the channel when performing task B is larger than when performing task A, it is considered that the channel is more related to function B, and therefore it is included in the channel set B, at this time the CCEP waveform of the channel and channel A1 are the same time in the time dimension, and the next electrical stimulation can be performed by the stimulation artifact state detection judgment. For example, the stimulation artifact intensity is used as the detection standard of the stimulation artifact state. Channel A1 is subjected to the first electrical stimulation A1 based on channel set A; because all channels in channel set A are associated with function A, it can be determined that all channels in channel set A have stimulation artifacts A1 caused by electrical stimulation A1 to a certain extent, but because the stimulation artifact intensity of each channel in channel set A is different, some channels may be less than the stimulation artifact intensity threshold, for example, channel A2 meets the stimulation artifact state requirement, at this time, according to the channel set sorting, the first electrical stimulation A2 is performed on channel A2, instead of cross-performing electrical stimulation B1 on channel B1 in channel set B, and there is no need to wait for the stimulation artifact duration.

[0058] According to the channel sorting of the stimulation artifact state, it can be ensured that the channel of the next electrical stimulation is not the same time as the CCEP waveform of the last electrical stimulation in the time dimension, and the data processing and result misjudgment of the CCEP waveform can be avoided. However, as the operation proceeds, it may lead to that the number of electrical stimulations performed on each channel is inconsistent. For example, as described above, according to the function-related channel set sorting, that is, channel set A > channel set B > channel set C, in the first round of electrical stimulation, channel A1, channel B1, and channel C3 are subjected to 1 electrical stimulation respectively; in the second round of electrical stimulation, channel A1 may not be subjected to electrical stimulation, at this time, the second electrical stimulation is performed on channel B1; or the first round of electrical stimulation has not been performed on channel C3, but channel A1 has met the stimulation artifact state requirement, and the electrical stimulation of channel A1 is preferentially performed, leading to that the number of electrical stimulations performed on each channel is different, that is, the confirmation progress of the pre-resection tissue related to different functions is inconsistent. Therefore, it is particularly important to evaluate the electrical stimulation progress according to the brain electrical activation of the channel which has not been subjected to electrical stimulation, and to dynamically adjust the channel set, in order to ensure the overall completion of the operation.

[0059] Of course, whether the function-related channel set contains single-function channel or multi-function channel, the next electric stimulation can be executed or skipped by detecting the stimulation artifact state. Only the principle can be expressed as the single-function channel subset or multi-function channel subset. Preferably, the channel set can be divided into single-function channel subset and multi-function channel subset in advance, the stimulation artifact state of the channel in the multi-function channel subset is detected, and the next electric stimulation is directly executed without detecting the stimulation artifact state of the channel in the single-function channel subset.

[0060] At least one embodiment also provides a cortical evoked electric stimulation device, comprising: a processor configured to obtain a sequence of electric stimulation of the cortical evoked electric stimulation; a human-computer interaction module configured to set the sequence of electric stimulation of the cortical evoked electric stimulation; and an electric stimulation module configured to execute electric stimulation on corresponding channels through an electric stimulation switch.

[0061] Optionally, referring to FIG. 6, the cortical evoked electric stimulation device mainly includes three parts: an upper computer, a lower computer, and hardware (i.e., a cortical electric stimulator). The delivery of the sequence of electric stimulation includes the entire process from the operation interface of the upper computer software to the analog switch of each electrode in the cortical electric stimulator. The specific working principle is as follows: the user selects or sets the priority of electric stimulation, such as channel set sorting and specific ways of channel sorting, on the operation interface of the upper computer software, the upper computer generates a preset sequence of electric stimulation of the cortical evoked electric stimulation through the processor, and sends the electric stimulation parameters to the lower computer through a command to make the lower computer adjust the working mode (normal acquisition mode or electric stimulation output mode) of each electrode (including the positive electrode and the negative electrode) in the electric stimulation mode. The lower computer generates the expected stimulation waveform according to the set electric stimulation parameters and channel configuration. The stimulation current flows from the stimulation electrode into the cortex, is conducted to other parts of the cortex through the effective connection path in the brain, and induces the CCEP waveform. Part of the CCEP waveform is recorded by the non-stimulation electrode (or recording electrode) on the cortical electrode sheet, and after the digital-analog conversion processing of the lower computer, the signal is input to the upper computer software, and the waveform is displayed on the upper computer interface after the CCEP processing. After the stimulation of the lower computer ends, the electrodes involved in the stimulation are connected to the bleeder switch for a period of time to complete the charge balance and de-artifact processing, and then the electrodes are restored to the normal acquisition mode.

[0062] Optionally, the electric stimulation switch comprises a collection head box needle plate and a connection switch on the collection head box needle plate; two ends of the connection switch are connected with all the electrodes and the collection probe respectively, and the connection switch provides four working modes for all the electrodes: ① normal collection mode (no stimulation current output), ② positive electrode output for electric stimulation, ③ negative electrode output for electric stimulation, and ④ access to a discharge switch to remove stimulation artifacts. The collection head box needle plate is mainly connected with all the electrodes (including collection channels and stimulation channels) through electrode lines. The collection probe is used for amplifying and collecting weak electrophysiological signals, and the data are transmitted to the upper computer in real time after being processed by the lower computer.

[0063] Further, the surgical progress evaluation module is further included to evaluate the electric stimulation progress according to the electroencephalogram activation degree of the channel without performing electric stimulation.

[0064] Further, the prompting module is further included to prompt the channel for performing next electric stimulation.

[0065] At least one embodiment further provides a computer device comprising a memory, a processor and a computer program stored in the memory, wherein the processor executes the computer program to obtain the preset electric stimulation sequence of the intercortical evoked potential.

[0066] In some embodiments, the surgical progress evaluation module is realized by a processor to perform the specific functions, and the processor module is electrically connected with the display module in a bus mode to execute the channel for next electric stimulation.

[0067] At least one embodiment further provides a computer readable storage medium having a computer program stored thereon, wherein the computer program is executed by a processor to obtain the preset electric stimulation sequence of the intercortical evoked potential.

[0068] At least one embodiment further provides a computer program product comprising a computer program, wherein the computer program is executed by a processor to obtain the preset electric stimulation sequence of the intercortical evoked potential.

[0069] In the description of the embodiments of the present application, unless otherwise explicitly specified and limited, the terms “mounting”, “connection” and “linking” should be understood in a broad sense, for example, can be fixed connection, can also be detachable connection, or integrally connected; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, and can be the communication inside two elements. For those skilled in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0070] In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first", "second", "third" are only for the purpose of description and cannot be understood as indicating or implying relative importance.

[0071] In several embodiments provided in the present application, it should be understood that the disclosed system, device and method can be implemented in other ways. The above-described device embodiments are only illustrative, for example, the division of the units is only a logical function division, and actual implementation can have another division manner, and for example, a plurality of units or components can be combined or integrated into another system, or some features can be ignored or not executed.

[0072] Based on the above ideal embodiments according to the present application, through the above description, relevant personnel can make various changes and modifications without deviating from the scope of the technical idea of the present application. The technical scope of the present application is not limited to the contents of the specification, and must be determined by the scope of the claims.

Claims

1. A method for acquiring an electrical stimulation sequence, characterized in that, include: Construct a set of channels related to the functionality; Channels are sorted according to the EEG activation level of the task; The sorted channel order is used as the preset electrical stimulation sequence for intercortical evoked electrical activity.

2. The method according to claim 1, characterized in that, The channel sorting also includes: the physical distance of the channel from the lesion area, i.e. The sets of channels with the same function are sorted in the order of interior, boundary, and exterior of the lesion area as the second channel subset > the third channel subset > the first channel subset.

3. The acquisition method according to claim 1, characterized in that, The methods for obtaining the brainwave activation level include: Divide the EEG signal segments, that is, divide the EEG signal segments corresponding to the task time into baseline segments and task segments according to the start point of the set task; Obtain data features, that is, calculate the data features of the baseline segment and the task segment respectively; The difference in the distribution of data features between the task segment and the baseline segment was examined to form a test matrix with dimensions representing channels and task time, respectively, to characterize the EEG activation of each channel when performing the same task.

4. The acquisition method according to claim 1, characterized in that, Also includes: When there are multiple sets of different channels with related functions, sort the channel sets.

5. The method according to claim 4, characterized in that, The sorting of the channel set includes: For any channel set that has not undergone electrical stimulation, alternative values ​​for the channel set are obtained based on the EEG activation level of the task; Sort the candidate values ​​corresponding to different channel sets to obtain the sequence of the channel sets.

6. The method according to claim 4, characterized in that, Constructing a collection of different channels related to multiple functions includes: Get the initial set of channels related to any function; Compare multiple functionally related initial channel sets; Channel avoidance involves selecting one duplicate channel and incorporating it into the initial channel set, resulting in multiple functionally related channel sets, so that there are no duplicate channels among the channel sets.

7. The method according to claim 1, characterized in that, It also includes adjusting the preset electrical stimulation sequence based on the stimulation artifact state of the channel after electrical stimulation; The adjustment of the preset electrical stimulation sequence includes: Step S1: Select the electrical stimulation channel and perform the initial electrical stimulation; Step S2: Check whether the channels in each channel set meet the stimulus artifact state requirements according to the channel set sorting. If the requirements are met, then channels in the channel set are selected according to the channel order to perform electrical stimulation; If the requirements are not met, leave it empty; Repeat step S2 until the channel reaches the set number of electrical stimulations.

8. An electrical stimulation device for intercortical evoked electricity, characterized in that, include: A processor for performing the steps of the method as described in any one of claims 1-7 to obtain a preset electrical stimulation sequence for intercortical evoked electrical activity; The human-computer interaction module is used to set the electrical stimulation sequence for intercortical evoked electrical activity; The electrical stimulation module applies electrical stimulation to the channels via an electrical stimulation switching switch.

9. The electrical stimulation device for intercortical evoked electricity according to claim 8, characterized in that, It also includes a progress assessment module, which assesses the progress of electrical stimulation based on the EEG activation levels of channels that have not undergone electrical stimulation. It also includes a prompting module to prompt the channel to perform the next electrical stimulation.

10. A computer device comprising a memory, a processor, and a computer program stored in the memory, characterized in that, The processor executes the computer program to implement the steps of the method as described in any one of claims 1-7.

11. A computer-readable storage medium having a computer program stored thereon, characterized in that, When the computer program is executed by a processor, it implements the steps of the method as described in any one of claims 1-7.

12. A computer program product, comprising a computer program, characterized in that, When the computer program is executed by a processor, it implements the steps of the method as described in any one of claims 1-7.

Images