Nebulization assistant device and nebulization system

Abstract

The present application relates to the technical field of nebulizer therapy, and in particular, to a nebulization assistant device and a nebulization system. The nebulization assistant device comprises an assistant respirator and an information processing module, and can be used in cooperation with an inhalation administration module for providing a patient with a drug for respiratory administration via nebulization, so as to constitute the nebulization system. The information processing module acquires a respiratory frequency of the patient on the basis of a time series of respiratory sounds collected by a respiratory sound collection unit, and determines a start time of an inflatable garment according to a matching condition between the respiratory frequency of the patient and a drug supply frequency of the inhalation administration module. On the basis of the correlation analysis between respiratory sound / lung sound signals collected by the assistant respirator and drug flow data, the information processing module generates an adjustment instruction regarding the nebulization position, respiratory mode, and / or nebulization drug proportions.

Description

Atomization auxiliary device and atomization system TECHNICAL FIELD

[0001] The present application relates to the technical field of atomization therapy, in particular to an atomization auxiliary device and an atomization system. BACKGROUND

[0002] Atomization therapy is an important clinical intervention method in the field of respiratory diseases and otolaryngology. The core medical equipment involved in the treatment process mainly includes jet atomization device, ultrasonic atomization generator and oxygen-driven atomization system. The existing technology has a delay in the response of atomization parameter control, and usually only the parameter correction can be carried out after the clinical indications or adverse reactions appear. For pediatric patient groups, due to the mismatch between respiratory rhythm and device working cycle, super-dose drug inhalation is often needed to achieve the predetermined treatment effect.

[0003] In the existing technology of respiratory frequency and atomization frequency, CN116212177A discloses an atomization drug delivery system and a control method thereof, the control method comprising: acquiring a breathing signal detected by a breathing sensor located on a first air duct; determining a breathing state through the breathing signal; if the breathing state is an inhalation state, adjusting the frequency of an atomization device in the atomizer through a host of the atomizer to control the atomization device to atomize the stored drug, and transmit the atomized drug into the first air duct; if the breathing state is an exhalation state, adjusting the frequency of the atomization device through the host to control the atomization device to stop atomizing the drug; acquiring the exhaled gas through a lung function tester located on a second air duct, and calculating the vital capacity parameter according to the gas.

[0004] The above-mentioned technical solution focuses on breathing synchronization control, and does not set an atomization effect dynamic monitoring module. Although the existing solution can alleviate the problem of breathing-atomization airflow interference, it lacks a real-time evaluation mechanism for atomization deposition efficiency, and does not integrate multi-dimensional regulation parameters affecting atomization transmission efficiency. The current clinical evaluation system generally has a time lag, and usually needs to observe for several days, combine with cough symptom score and lung function retest to determine the treatment effect. It is urgent to develop a closed-loop management system integrating real-time atomization effect monitoring and intelligent regulation. SUMMARY

[0005] The prior art has emerged from the physiological parameters such as the respiratory rate of the patient to adaptively adjust the oxygen flow rate and the flow rate of the aerosol drug gas to achieve the balance of the inhaled and exhaled amounts to ensure the full absorption of the drug. For example, CN116920229A discloses an old respiratory patient aerosol device, which comprises an aerosol mask, an oxygen source, a sprayer, a gas supply chamber, a breathing detection instrument and a controller. The sprayer is connected with a high-pressure gas pump on one side to disperse the solution contained in the interior through the input gas flow, and is also connected with a spray valve on the other side to output the dispersed drug mist. The spray valve is provided with an aerosol flow meter to detect the real-time dispersion particle size and the aerosol flow rate of the drug mist. The technical solution adjusts the initial gas flow rate according to the change rate of the real-time respiratory rate and the second standard respiratory rate to ensure that the aerosol oxygen supply is consistent with the respiratory rate, that is, the respiratory rate is faster, and a higher gas flow rate is used to generate a higher spray to make the drug better inhaled by the user. The controller adjusts the drug particle size and the drug spraying flow rate to improve the drug utilization rate. However, the process of subtracting the gas flow from the measured exhaled gas in the technical solution essentially obtains the difference between the human exhaled gas flow and the gas flow input into the mask. For a specific human body, the gas inhaled by the human body and the gas exhaled by the human body are not equivalent, that is, the gas flow is not equivalent, so that the measurement of the exhaled gas flow cannot be associated with the amount of drug inhaled into the respiratory tract of the user, and thus an accurate flow adjustment strategy matching the real-time physiological state of the patient cannot be obtained.

[0006] The present application provides an aerosol system, which comprises: an inhalation drug delivery module configured to provide a patient with a drug for administration through the respiratory tract in an aerosol manner, which is provided with a flow detection device to obtain time-dependent drug flow data when the patient uses it; an auxiliary respirator configured to be attached to the body surface of the patient's respiratory tract area to collect time-dependent respiratory sound / pulmonary sound signals when the patient uses it; and an information processing module for generating instructions for adjusting the inhalation drug delivery module based on the information collected by the auxiliary respirator.

[0007] Based on the correlation analysis of the respiratory sound / pulmonary sound signals and the drug flow data collected by the auxiliary respirator, the information processing module generates adjustment instructions for the aerosol position, the breathing mode and / or the aerosol drug ratio.

[0008] Compared with the prior art described above, the information processing module of the present application can perform correlation analysis on the respiratory sound / pulmonary sound signals and the drug flow data collected by the auxiliary respirator, and generate adjustment instructions for the inhalation drug delivery module regarding the aerosol position, the breathing mode and / or the aerosol drug ratio. Based on the above technical features, the problems to be solved by the present application can include: how to adjust the implementation parameters of the aerosol treatment according to the real-time physiological state of the patient, and respond to the changes in the physiological state of the patient in time, and improve the efficiency of the aerosol treatment.

[0009] The present application uses respiratory sound / pulmonary sound signals to evaluate the breathing state of the patient during nebulization, and obtains the effect of the patient during nebulization in real time through the breathing state, such as the relief of sputum wetness. On the one hand, the effect of the patient during nebulization can confirm whether the nebulization program can make the drug reach the target area. On the other hand, the relief or no change of the respiratory tract / lung symptoms of the patient represented by the respiratory sound / pulmonary sound signals can confirm whether the nebulized drug takes effect on the patient.

[0010] The adjustment process relies on respiratory sound / pulmonary sound signals. The data fed back by such signals is the reaction of the area directly acted on by the nebulized drug. Compared with the prior art method of cooperating with the patient during nebulization to improve the nebulization efficiency, the present application can generate adjustment instructions for the nebulization device in real time according to the feedback generated by the directly acted area.

[0011] According to a preferred embodiment, the information processing module is configured to generate a nebulization flow rate adjustment instruction related to the patient's breathing frequency adjustment based on the frequency of the respiratory sound / pulmonary sound signals collected by the auxiliary respirator.

[0012] The prior art has appeared technical solutions for realizing efficient inhalation of liquid medicine in the upper respiratory tract or lungs by synchronizing the breathing frequency of the patient during the breathing process. For example, CN115569275A discloses a medical micro-network type nebulization method and system with synchronized breathing frequency, which includes an electrocardio and respiration monitoring unit, a nebulization control unit, a nebulization driving unit, and a micro-network type nebulization sheet. The electrocardio and respiration monitoring unit monitors the real-time breathing state of the human body, monitors the real-time data of the breathing state of the patient during nebulization treatment, and transmits it to the nebulization control unit. The nebulization control unit extracts real-time feature parameters of the breathing state according to the real-time data of the breathing state of the patient during nebulization, and controls and adjusts the increase or decrease of the driving peak voltage and vibration frequency of the micro-network type nebulization sheet through the boost control driving circuit and the frequency modulation control driving circuit of the nebulization driving unit, so that the driving peak voltage and vibration frequency change with the real-time feature parameters of the breathing state, realizing the real-time synchronization of the nebulization amount and the nebulization rate of the nebulization system with the breathing rhythm. The change period of the nebulization amount and the nebulization rate of the nebulization system of this technical solution can be real-time synchronized with the breathing rhythm of the patient, thereby solving the technical problems that the existing nebulization system cannot adapt to the patient's breathing, resulting in that the liquid medicine cannot be efficiently inhaled into the upper respiratory tract or lungs, and the safe nebulization state of the patient cannot be monitored.

[0013] The present application is provided with an auxiliary respirator for prompting the patient to exhale or inhale. The information processing module controls the auxiliary respirator to generate a corresponding breathing prompt at a preset time (e.g. 0.5s) earlier than the dosing rhythm of the inhalation dosing module, so as to correct the time error caused by the simultaneous action of the patient's inhalation and the dosing action of the nebulizer.

[0014] In existing technologies, the matching of respiratory rate and drug administration rate mostly relies on the patient's self-regulation of breathing rhythm, but ignores the transmission delay caused by the drug administration route, which makes the coordination between the two affected by objective factors such as tubing resistance.

[0015] This application addresses the problem of transmission lag in the drug delivery pathway, ensuring that the coordination between the device's drug delivery frequency and respiratory rate is only affected by the patient's compliance, thus eliminating interference from objective factors such as tubing resistance.

[0016] According to a preferred embodiment, the information processing module is configured as follows:

[0017] Based on the intensity of breath sound / lung sound signals collected by the ventilator, nebulized particle adjustment instructions are generated in relation to changes in the patient's sputum-dampness symptoms.

[0018] According to a preferred embodiment, the information processing module is configured to generate adjustment instructions to alleviate abnormal symptoms caused by nebulization in patients based on abnormal changes in breath sound / lung sound signals collected by the ventilator.

[0019] Compared with the prior art, the information processing module of the present invention can generate nebulized particle adjustment instructions related to changes in the patient's phlegm-dampness symptoms based on the intensity of the breath sound / lung sound signals collected by the ventilator. Based on the above distinguishing technical features, the problem to be solved by the present invention may include: how to adjust the site of drug action under phlegm-dampness symptoms to improve the effectiveness of the corresponding drug in treating specific diseases.

[0020] The diameter of nebulized particles is a crucial factor influencing drug deposition in different parts of the respiratory tract. Existing technologies, such as the personalized, precise positioning, and intelligent control nebulization system disclosed in CN117224786A, adjust the size of nebulized particles by inverting and calculating the inhalation parameters deposited at that location. Numerical simulation combined with nebulization experiments is used to study the deposition patterns of novel compound nebulized drug particles in the human airway, establishing a database of different drug inhalation parameters to evaluate the matching degree between nebulized particle diameter and patients.

[0021] In actual operation, due to individual differences, the calculation model is affected by individual differences (for example, patients with complications, patients with congenital stenosis of the respiratory tract), which increases the error of the atomized particle adjustment, and further causes the problem that the adjusted parameters are not applicable to the patient. Unlike the prior art described above, the present application is based on the dynamic change information of the lung sound / respiratory sound detected in real time to determine whether the current atomized particle size matches the site where it is to be deposited. Specifically, by comparing the lung sound / respiratory sound generated by each site of the same patient before and during atomization, the information processing module can obtain the audio generated by the atomized airflow in the lung sound / respiratory sound by excluding the lung sound / respiratory sound generated by the patient's normal breathing in the audio during atomization. The site where the audio is generated can determine the end point of the atomized airflow, thereby confirming the effect of the current atomization.

[0022] According to a preferred embodiment, the information processing module is configured to connect with the remote medical side, and when the remote medical side receives the patient's single or multiple respiratory sound / lung sound signals collected by the auxiliary respirator, the information processing module controls the inhalation administration module to adjust the drug ratio of the patient's atomization based on the drug ratio instruction sent by the remote medical side.

[0023] The adjustment of the drug ratio involved in the present application is applicable to patients with chronic diseases who need long-term or high-frequency home atomization, such as patients with chronic obstructive pulmonary disease. Such patients have limited mobility and are easily affected by the environment to cause disease manifestations in the lungs that affect the quality of life, such as sputum coughing and wheezing in smog weather. However, due to the influence of mobility, going to the hospital for examination when the disease manifestations appear will reduce the patient's subjective initiative to atomize or the enthusiasm to replace the drug to reduce the impact of disease manifestations on the quality of life.

[0024] The system involved in the present application can realize remote communication with medical personnel responsible for the diagnosis and treatment of patients with chronic diseases under the authorization of the HIS system (Hospital Information System) loaded in the hospital, and adjust the drug ratio of atomization under the guidance of the medical personnel within the allowed permission (for example, sending the patient's affected symptoms to the medical personnel or sending the patient's medical history to the medical personnel under the permission of both parties).

[0025] The present application takes into account the adaptability of the drug to the patient during use, and also takes into account the drug ratio of each atomization in a treatment course, so that the entire atomization treatment course can change with the patient's body changes (for example, the development of respiratory diseases or changes caused by environmental influences), and the changes not only occur during atomization, but also occur before and after single atomization, which makes the system involved in the present application adapt to the development of the patient's condition and improves the atomization effect.

[0026] According to a preferred embodiment, the auxiliary respirator comprises a respiratory sound collecting unit capable of collecting respiratory sounds of the upper respiratory tract and the lungs of the patient.

[0027] According to a preferred embodiment, the auxiliary respirator further comprises an inflatable garment for assisting the patient in adjusting the respiratory frequency, wherein the inflatable garment is configured as a garment capable of being worn on the body of the patient, the garment comprising a garment front, a garment back, and at least an inflatable air bag incorporated in or on the garment front, the garment front and / or the garment back comprising a recess configured to press against the body surface of the patient and to place the respiratory sound collecting unit.

[0028] According to a preferred embodiment, when the inflatable air bag is inflated so that the worn garment presses against the body surface of the patient, the respiratory sound collecting unit placed in the recess is capable of collecting at least the bronchial breath sound, the alveolar breath sound and / or the bronchoalveolar breath sound of the patient.

[0029] According to a preferred embodiment, the inhalation administration module comprises a driving unit, a drug liquid cartridge adjusted by the driving unit, and an atomization unit for aerosolizing the drug liquid, wherein the driving unit comprises a connector assembly arranged between the drug liquid cartridge and the atomization unit, the connector assembly comprising a needle and a liquid suction pump, the needle being capable of piercing a drug bottle clamped on the drug liquid cartridge and causing the drug liquid in the drug bottle to flow into the atomization unit under the action of the liquid suction pump under the adjustment of the information processing module.

[0030] According to a preferred embodiment, the drug liquid cartridge comprises a first drug liquid cartridge and a second drug liquid cartridge, the first drug liquid cartridge and the second drug liquid cartridge being capable of being separately adjusted by the driving unit for administration.

[0031] The present application also provides an atomization assistance device capable of being used in cooperation with an inhalation administration module for providing a patient with a respiratory tract administration of a drug in an atomized manner, comprising an auxiliary respirator and an information processing module. The auxiliary respirator is configured to be attached to the body surface of the patient in the respiratory tract region of the patient to collect the time-dependent respiratory / lung sound signals of the patient in use, wherein the auxiliary respirator comprises an inflatable garment capable of being worn on the body of the patient for assisting the patient in adjusting the respiratory frequency, and a respiratory sound collecting unit arranged on the inflatable garment for collecting the lung / respiratory sound of the patient. The information processing module is used for analyzing and processing the information collected by the auxiliary respirator to generate adjustment instructions. The information processing module acquires the respiratory frequency of the patient based on the time-series data of the respiratory sound collected by the respiratory sound collecting unit, and determines the start time of the inflatable garment according to the matching condition of the respiratory frequency of the patient and the drug supply frequency of the inhalation administration module.

[0032] According to a preferred embodiment, when the information processing module determines that the respiratory frequency of the patient does not match the drug supply frequency of the inhalation administration module, the inflatable garment is turned on to assist the patient in adjusting the respiratory frequency.

[0033] According to a preferred embodiment, the fluid supply unit is capable of inflating and deflating the inflatable air bag of the clothing at the same frequency as the drug supply frequency of the inhalation drug delivery module when the inflatable clothing is in operation. BRIEF DESCRIPTION OF DRAWINGS

[0034] Fig. 1 is a use state diagram of the atomization system provided by the present application;

[0035] Fig. 2 is a hardware connection diagram of the atomization system provided by the present application;

[0036] Fig. 3 is an information interaction schematic diagram of each functional module of the atomization system provided by the present application;

[0037] Fig. 4 is a detection flowchart provided by the present application.

[0038] LIST OF REFERENCE NUMERALS 100: assisted respirator; 110: respiratory sound collection unit; 120: inflatable clothing; 121: clothing; 1211: clothing front; 1212: clothing back; 122: inflatable air bag; 123: fluid supply unit; 200: information processing module; 300: inhalation drug delivery module; 310: driving unit; 320: atomization unit; 330: drug liquid box; 331: first drug liquid box; 332: second drug liquid box; 340: scanning lens. DETAILED DESCRIPTION

[0039] The following will be described in detail with reference to the accompanying drawings.

[0040] Embodiment 1

[0041] The present embodiment provides an atomization system, in particular, a system for evaluating the matching degree of atomization speed, atomization particle and atomization drug ratio with patients based on the real-time treatment effect represented by the results of feedback of children's respiratory sound / pulmonary sound signals when children are atomized.

[0042] The present embodiment provides an atomization system, in particular, a system for evaluating the matching degree of atomization speed, atomization particle and atomization drug ratio with patients based on the real-time treatment effect represented by the results of feedback of adult patients' respiratory sound / pulmonary sound signals when adult patients with respiratory diseases are atomized. In particular, the system involved in the present application is suitable for the elderly with a long-term history of home atomization.

[0043] Fig. 2 shows the functional structure diagram of the present system. In the present application, the assisted respirator 100, the information processing module 200 and the inhalation drug delivery module 300 can establish a communication connection such as data, signals and / or control signals through a wireless network (such as Bluetooth, WIFI, NFC, infrared technology, etc.).

[0044] The present application relates to an assisted breathing device 100. The assisted breathing device 100 comprises a respiratory sound collecting unit 110 for collecting the lung / respiratory sound of a patient, and an inflatable garment 120 for assisting the patient to adjust the breathing frequency. Preferably, the assisted breathing device 100 further comprises a power supply unit for supplying power to the respiratory sound collecting unit 110 and the inflatable garment 120, a communication module for receiving the instructions sent by the information processing module 200, and a microprocessor for converting the data collected by the respiratory sound collecting unit 110 to increase the speed of the communication module for presenting the data to the information processing module 200. The communication module can send the collected information to the information processing module 200 through a cable port, a wireless transmitter or a combination of the above signal transmission methods. Preferably, the information processing module 200 is integrated on an inhalation administration module 300, or integrated on a handheld terminal of the patient, so that the patient can adjust the inhalation administration module 300 through a handheld terminal such as a mobile phone.

[0045] The respiratory sound collecting unit 110 is provided with a stethoscopic collecting circuit and a differential amplification circuit. The stethoscopic collecting circuit and the differential amplification circuit can be set as the collecting circuit disclosed in CN217904638U.

[0046] As shown in FIG. 1, the inflatable garment 120 is configured as a garment 121 that can be worn on the body of the patient, the garment 121 comprising a garment front surface 1211, a garment back surface 1212, and at least one inflatable air bag 122 incorporated in or on the garment front surface 1211, the garment front surface 1211 and / or the garment back surface 1212 comprising a recess configured to be pressed against the body surface of the patient for placing the respiratory sound collecting unit 110.

[0047] The garment 121 can be set as an inflatable vest or other clothing that can be sleeved on the chest to generate a squeezing feeling on the chest of the patient. The inflatable air bag 122 provided on the garment 121 can generate a corresponding inflation or deflation program accompanying the exhalation or inhalation action of the patient. When the patient needs to maintain the inhalation action, the inflatable air bag 122 is in a deflated state, allowing the patient to expand the chest and / or abdominal cavity. When the patient needs to maintain the exhalation action, the inflatable air bag 122 is in an inflated state, allowing the patient to contract the chest and / or abdominal cavity.

[0048] Specifically, the inflatable air bag 122 provided on the garment 121 needs to squeeze the chest of the patient when inflated so that the patient feels the squeezing feeling of the chest, or through the deflation of the inflatable air bag 122, the patient feels the relaxation feeling of the chest, thereby ensuring that the patient can adjust the breathing frequency through the perception.

[0049] When the inflatable air bag 122 is inflated so that the worn garment 121 is pressed against the patient's body surface, the breath sound collection unit 110 placed in the recess can at least collect the patient's bronchial breath sound, alveolar breath sound and / or bronchial alveolar breath sound. Preferably, the garment 121 is provided with a recess at the upper, middle and lower parts of the patient's midclavicular line, the upper and lower parts of the anterior axillary line, and the upper and lower parts of the midaxillary line, or a recess corresponding to the auscultation array disclosed in CN217904638U is provided on the garment 121. Preferably, one breath sound collection unit 110 or multiple breath sound collection units 110 are placed in one recess. The breath sound collection unit 110 is flush with the surface of the garment 121. A connecting piece is provided inside the recess for detachably connecting the breath sound collection unit 110 to the garment 121. The connecting piece can be a button, a hook, a magnetic button, a shelf, a magic tape, etc.

[0050] Another aspect of the present application also relates to an inhalation administration module 300. As shown in FIG. 1 and FIG. 2, the inhalation administration module 300 comprises a driving unit 310, a drug liquid cartridge 330 adjusted by the driving unit 310, and an atomization unit 320 for aerosolizing the drug liquid.

[0051] The drug liquid cartridge 330 is connected to the atomization unit 320 by the driving unit 310 and is controlled by the driving unit 310 to adjust the amount and variety of drugs flowing into the atomization unit 320. Preferably, the drug liquid cartridge 330 comprises a first drug liquid cartridge 331 and a second drug liquid cartridge 332, which can be independently adjusted by the driving unit 310 to administer drugs. Preferably, when mixed administration is required, the driving unit 310 can simultaneously control the flow of drugs in the first drug liquid cartridge 331 and the second drug liquid cartridge 332 into the atomization unit 320. It should be noted that the number of drug liquid cartridges 330 is not limited, and the first drug liquid cartridge 331 and the second drug liquid cartridge 332 are only a preferred embodiment. The number of drug liquid cartridges 330 in the present application can be set to two or more, and each can be independently controlled by the driving unit 310.

[0052] The atomization unit 320 can be a device that changes the physical form of the drug liquid in an ultrasonic or high-speed jet manner, which can spray the incoming drug liquid in the form of aerosol. Preferably, the atomization unit 320 is set as an ultrasonic device. The power of the atomization unit 320 can be controlled and adjusted.

[0053] The driving unit 310 generates corresponding drug liquid adjustment actions upon receiving instructions transmitted by the communication module and sent by the information processing module 200.

[0054] When the medicine box 330 is a holding container based on the manual addition of medicine by the operator as shown in the prior art, the driving unit 310 can be set as a pump which can select the amount of medicine suction by adjusting the power. When the medicine box 330 is set as two or more, the pump of the driving unit 310 can be set corresponding to each medicine box 330, or a controlled valve is set between each medicine box 330 and the atomization unit 320. The transmission speed / amount of the medicine of different medicine boxes 330 is adjusted by adjusting the power of the pump and the opening and closing of the valve.

[0055] Further, considering that the atomization treatment is carried out in a course of treatment, the patient needs to clean the medicine box 330 every time he atomizes, and the application sets a disposable medicine bottle and an inhalation administration module 300 used in cooperation with the medicine bottle.

[0056] As shown in FIG. 1, the driving unit 310 includes a connector assembly arranged between the medicine box 330 and the atomization unit 320. The medicine box 330 is arranged in the shape of a medicine bottle that can be engaged. The connector assembly sleeves the liquid outlet end of the medicine bottle and opens an opening in the engaged liquid outlet end of the medicine bottle by screwing, needle piercing and other means. Preferably, the connector assembly includes a needle and a suction pump. Under the adjustment of the information processing module 200, the needle can pierce the medicine bottle engaged in the medicine box 330 and make the medicine in the medicine bottle flow into the atomization unit 320 under the action of the suction pump. The medicine obtained by this method can avoid pollution caused by contact with air.

[0057] According to a preferred embodiment, the medicine box 330 is provided with a scanning lens 340 corresponding to the position of the bottle body. When the medicine bottle is engaged on the medicine box 330, the scanning lens 340 confirms whether the medicine is correctly selected by obtaining the bottle body information or other information (such as a two-dimensional code) existing on the bottle body.

[0058] Another aspect of the application relates to an information processing module 200. The information processing module 200 can be a smart phone, a smart watch or other wearable device, a tablet computer, a computer, a cloud server or other smart device with CPU and communication module, which can be worn on the body of the guardian of the patient. When the guardian is not around the patient, the conscious adult patient can wear the atomization device by himself and confirm whether the medicine is correctly added based on the scanning lens 340. When the operation procedure is correct, the guardian can remotely control the system to start. The CPU receives the detection signal sent by the auxiliary respirator 100 through the communication module and converts the detection signal into processable data for further generating a signal for controlling the inhalation administration module 300.

[0059] Alternatively, the information processing module 200 can be integrated in the assisted respirator 100 or the inhalation administration module 300. The patient can realize the program adjustment of the atomization process based on the lung sound / respiratory sound feedback during the atomization process by operating the assisted respirator 100 or the inhalation administration module 300.

[0060] In the embodiment, the assisted respirator 100 takes the inflatable vest as an example. As shown in FIG. 1, after the patient wears the assisted respirator 100, the assisted respirator 100 is connected around the patient's chest through the front buckle, zipper and other connecting components.

[0061] After the system is woken up by the external input information, the respiratory sound collecting unit 110 starts to collect the initial lung sound / respiratory sound of the patient without atomization.

[0062] Through the confirmation of the external input information, after the patient correctly wears the inhalation administration module 300, the inhalation administration module 300 starts to work based on the preset program (such as the mixed interferon and physiological saline into the liquid box 330, starting to work with 4 μm atomized particles and 0.8 mL / min spray speed).

[0063] The collected data of the respiratory sound collecting unit 110 is presented to the communication module of the assisted respirator 100 after being processed by the microprocessor of the assisted respirator 100, and is sent to the communication module of the information processing module 200 through the communication module. The CPU of the information processing module 200 processes the relevant information, that is, generates the information such as the respiratory frequency and sputum wetness of the patient based on the sound tone and other ripple curve characteristics of the respiratory sound / lung sound. The CPU generates at least three kinds of judgments by comparing the respiratory sound / lung sound sent at different time periods, including whether there is a situation that needs to stop the atomization and send the early warning broadcast instruction through the set voice broadcast unit; the coordination of the respiratory frequency of the patient and the administration frequency of the inhalation administration module 300; whether the respiratory sound / lung sound of the patient's exacerbation tendency is relieved (such as whether the duration of wheezing sound is reduced).

[0064] Meanwhile, based on the frequency of the inhalation administration module 300, the CPU can control the inflatable garment 120 to inflate (inflation) or deflate (deflation) at a preset time value through the communication module of the assisted respirator 100, wherein the assisted respirator 100 can adjust the inflation and deflation of the inflatable garment 120 by controlling the fluid supply unit 123. For example, when the inhalation administration module 300 sprays the drug into the mouth and nose of the patient, based on the transmission time of the drug in the pipeline, the CPU controls the inflatable garment 120 to relax 0.5s later, so as to correct the time error caused by the synchronization of the inhalation action of the patient and the administration action of the atomizer due to the atomization transmission, and ensure that the inhalation of the patient and the administration are synchronized. At the same time, the time of the inflatable garment 120 relaxation is the time of the administration of the inhalation administration module 300. For example, the inhalation administration module 300 sprays the drug for 3s, the inflatable garment 120 relaxes for 3s, and the inflatable garment 120 inflates for 3s within 3s after the inhalation administration module 300 stops administration, so that the patient continues to exhale within 3s of the inflation of the inflatable garment 120.

[0065] According to a preferred embodiment, the present application also relates to an atomization assistance device comprising the above-mentioned assisted respirator 100 and the above-mentioned information processing module 200, wherein the atomization assistance device can be used in cooperation with the above-mentioned inhalation administration module 300 for providing a patient with a respiratory tract administration drug in an atomization mode.

[0066] Embodiment 2

[0067] The present embodiment provides an atomization administration method for adjusting the breathing frequency, as shown in FIG. 4, which can be used in the atomization assistance device and / or the atomization system described in the previous embodiments. In the present embodiment, the hardware is the same as that in the previous embodiments, except that the control method of the information processing module 200 on the inhalation administration module 300 is different.

[0068] Based on the correlation analysis of the respiratory sound / pulmonary sound signals collected by the assisted respirator 100 and the drug flow data, the information processing module 200 generates adjustment instructions for the breathing mode, as shown in FIG. 3.

[0069] Based on the frequency of the respiratory sound / pulmonary sound signals collected by the assisted respirator 100, the information processing module 200 generates atomization flow rate adjustment instructions related to the adjustment of the breathing frequency of the patient, as shown in FIG. 3.

[0070] Specifically, the information processing module 200 obtains the breathing frequency of the patient based on the time sequence data of the respiratory sound collected by the respiratory sound collection unit 110, and matches the supply frequency of the inhalation administration module 300.

[0071] When the breathing frequency of the patient does not match the supply frequency, the inflatable garment 120 starts to work.

[0072] The fluid supply unit 123 inflates and deflates the inflatable air bag 122 of the clothing 121 at the same frequency as the drug supply frequency. The patient wearing the clothing 121 can synchronize the breathing frequency after feeling the compression and relaxation of the clothing 121, so that the patient's breathing can be automatically matched with the drug supply frequency, thereby achieving the optimal drug supply effect.

[0073] At the same time, considering that the inhalation drug delivery module 300 delivers drugs to the patient in a pipeline manner, adjusting the drug supply frequency and the breathing frequency to be consistent in time will cause errors in the time of drug flow through the pipeline and the time of airflow transmission during patient breathing, resulting in a mismatch between the patient's inhalation action and the inhalation drug delivery module 300's drug delivery action. The information processing module 200 can control the auxiliary respirator 100 to generate a corresponding breathing prompt at a preset time earlier than the inhalation drug delivery module 300's drug delivery rhythm, in order to correct the time error caused by the synchronization of the patient's inhalation action and the inhalator's drug delivery action due to atomization transmission. Preferably, the preset time can be automatically adjusted during device use, that is, the preset time will change as the flow rate of the atomized drug changes. Generally speaking, the faster the flow rate, the shorter the preset time in the same pipeline.

[0074] Embodiment 3

[0075] This embodiment provides an atomization drug delivery method for adjusting the proportion of atomized drugs, as shown in FIG. 4. The atomization drug delivery method can be used in the atomization auxiliary device and / or atomization system described in the previous embodiments. In this embodiment, the information processing module 200 controls the inhalation drug delivery module 300 in a different way, and the other hardware is the same as in the previous embodiments.

[0076] Based on the correlation analysis of the respiratory / lung sound signals collected by the auxiliary respirator 100 and the drug flow data, the information processing module 200 generates adjustment instructions for the proportion of atomized drugs, as shown in FIG. 3.

[0077] For patients who need long-term atomization such as chronic lung obstruction, the information processing module 200 involved in this application can provide the patient's lung / respiratory sound to the medical staff or provide the medical staff with an atomization drug adjustment scheme based on the patient's lung / respiratory sound at different times of atomization by interfacing with the hospital information system (Hospital Information System).

[0078] The information processing module 200 can confirm the atomization effect of the patient by analyzing the timing data of the collected lung / respiratory sound.

[0079] The information processing module 200's judgment of the drug matching degree in the atomization treatment includes two judgment mechanisms, a and b:

[0080] a. After obtaining the respiratory / lung sound collected by the respiratory sound collecting unit 110, the information processing module 200 confirms whether the patient has symptoms other than the treatment ability of the atomized drug based on the standard parameters of the preset respiratory / lung sound.

[0081] b. After obtaining the respiratory / lung sound collected by the respiratory sound collecting unit 110, the CPU of the information processing module 200 issues a query application to the database of the information processing module 200 to obtain the respiratory / lung sound data of the patient in the last atomization process closest in time to the current atomization times;

[0082] By comparing the historical respiratory / lung sound data with the respiratory / lung sound data generated by the current atomization, and combining the treatment ability of the atomized drug, it is determined whether the patient's symptoms related to the treatment ability of the atomized drug are alleviated.

[0083] Preferably, considering the effect of atomization on the patient, the CPU can obtain the respiratory / lung sound data of the patient in three atomizations.

[0084] For example: After the patient completes the fourth atomization, the information processing module 200 judges the respiratory / lung sound data collected by the respiratory sound collecting unit 110 according to programs a and b respectively.

[0085] Program a is the judgment of new symptoms. When the duration or frequency response value of the frequency of the disease-related sound of the respiratory sound collected by the respiratory sound collecting unit 110 is higher than the preset duration or frequency response value of the frequency of the disease-related sound of the respiratory sound, and the symptoms corresponding to the characteristics (such as tracheal spasm, respiratory tract stenosis) are not within the scope of treatment of the atomized drug (such as ambroxol hydrochloride injection with mucus excretion promoting effect), the information processing module 200 generates a scheme for supplementing the atomized drug related to the above-mentioned symptoms (such as expandable bronchus, terbutaline sulfate atomized liquid for relieving bronchospasm) and presents it to the HIS system through the communication module, and the medical staff confirms the executability of the scheme through the HIS system and feeds back to the information processing module 200, at the same time, the medical staff can also inform the patient or his guardian (contact person remaining in the HIS system) to go to the designated hospital to take medicine through the HIS system. After the information processing module 200 obtains the authorization of the medical staff, it can send instructions for adjusting the related drug to the inhalation administration module 300, that is, the next time of atomization, after the adjusted atomized drug (ambroxol hydrochloride injection, terbutaline sulfate atomized liquid) passes through the scanning lens 340 of the inhalation administration module 300 and successfully scans the code, the inhalation administration module 300 provides atomization treatment for the patient based on the drug ratio sent by the information processing module 200.

[0086] Program B is the judgment of old disease development. After obtaining the respiratory sound / pulmonary sound collected by the respiratory sound collection unit 110, the CPU of the information processing module 200 issues a query application to the database of the information processing module 200 to obtain the respiratory sound / pulmonary sound data of at least one atomization process of the patient and the current atomization times in time. By comparing the historical respiratory sound / pulmonary sound data with the respiratory sound / pulmonary sound data generated in this atomization, combined with the treatment ability of the atomized drug, it is judged whether the symptoms related to the treatment ability of the patient and the atomized drug are relieved. When the frequency response value of the wet rale of this time is higher than that of the last time, based on the sputum accumulation problem related to the lung or respiratory tract of the wet rale, the information processing module 200 generates a scheme of replacing the drug liquid with mucous discharge promoting effect or increasing the use amount of ambroxol hydrochloride injection with mucous discharge promoting effect, and presents it to the HIS system through the communication module. The medical staff confirms the executability of the scheme through the HIS system and feeds back to the information processing module 200. When the execution scheme is confirmed to be drug replacement, the medical staff can also inform the patient or his guardian (contact person remaining in the HIS system) to go to the designated hospital to take medicine through the HIS system. After the information processing module 200 obtains the authorization of the medical staff, it can send instructions related to drug adjustment to the inhalation administration module 300, that is, after the adjusted atomized drug (for example: the use amount of ambroxol hydrochloride injection is changed from 1mL to 2mL) passes through the scanning lens 340 of the inhalation administration module 300 and successfully scans the code, the inhalation administration module 300 provides atomization treatment for the patient based on the drug ratio sent by the information processing module 200.

[0087] Embodiment 4

[0088] The present embodiment provides an atomization administration method for adjusting the ratio of atomized drugs, as shown in FIG. 4, which can be used in the atomization auxiliary device and / or atomization system described in the previous embodiments. In the present embodiment, except that the control method of the information processing module 200 to the inhalation administration module 300 is different, the other hardware is the same as in the previous embodiments.

[0089] Based on the correlation analysis of the respiratory sound / pulmonary sound signal collected by the auxiliary respirator 100 and the drug flow data, the information processing module 200 generates adjustment instructions for the atomization position, as shown in FIG. 3.

[0090] The prior art points out that the size of the atomized particles is the main factor affecting the attachment position of the atomized drug: atomized particles with a diameter of more than 10μm can only accumulate in the oral cavity; atomized particles with a diameter of 5-10μm can flow into the throat of the patient; atomized particles with a diameter of 3-5μm can flow into the lung parenchyma and bronchus of the patient; atomized particles with a diameter of 1-3μm can flow into the deep lung of the patient; atomized particles with a diameter of less than 1μm will be exhaled with breathing.

[0091] The respiratory sound collecting unit 110 involved in the present application can acquire the respiratory sound of the patient's respiratory tract and the lung sound of the patient's lung based on auscultation acquisition circuits respectively arranged at the patient's upper respiratory tract and lung, and more specifically, the auscultation acquisition circuits can also acquire the patient's respiratory sound and lung sound at different positions of the patient's chest and back. For example, the auscultation acquisition circuits are arranged at the positions of the suprasternal fossa, suprasternal fossa, throat and / or cervical 6-7 bone joints to collect the respiratory sound of different respiratory tract branches.

[0092] Even if the size of the atomized particles is 3-5 μm in diameter, the depth of the position reached by the drug will vary with individual differences (the state of the respiratory tract mucosa, the diameter of the respiratory tract, etc.). Based on the acquired lung sound / respiratory sound, the present application can timely know the depth of the atomized drug in the patient's respiratory tract and lung during the atomization process, so that the inhalation administration module 300 can make more accurate adjustments within the preset size range of the atomized particles. The adjustment mode includes changing the operating power of the atomization unit 320.

[0093] When the patient is atomizing, the airflow sound of atomization will cause the respiratory sound and lung sound collected by the respiratory sound collecting unit 110 to contain other frequency characteristic sounds. Based on the frequency characteristic sounds collected at different positions, the information processing module 200 can obtain the depth of the atomized drug. Based on the pre-set depth of the drug reaching the patient's lung (pulmonary parenchyma), and only when the sound with the frequency characteristic of the atomized airflow is detected at the lower bronchus, the information processing module 200 can control the atomization unit 320 to adjust the operating power, so that the size of the atomized particles is reduced by one unit. Preferably, one unit is a preset value, which can change the diameter of the atomized particles by 0.5 μm.

[0094] Embodiment 5

[0095] In the continuous multiple atomization process, the lung respiratory sound of the patient will change (such as aggravation or alleviation), which can be reflected in the duration of the wheezing sound of the patient and the main frequency of the wheezing sound. When the patient's trachea containing bronchus, bronchiole or small bronchiole changes partially (such as blockage or aggravation of sputum wetness), the resistance of airflow passing through the above-mentioned parts becomes larger, thereby causing the duration of wheezing sound in lung sound to increase and the pitch of wheezing sound to become higher.

[0096] According to a preferred embodiment, the respiratory sound collecting unit 110 is arranged at positions corresponding to the patient's main bronchus, left bronchus, left lung, right lung and right bronchus. When the lung sound information collected by the respiratory sound collecting unit 110 at some of the positions changes abnormally, the information processing module 200 can control the respiratory sound collecting unit 110 at other positions to stop collecting information, so as to increase the accuracy of information collection.

[0097] For example, when the pitch of wheezing sound collected by the breathing sound collection unit 110 arranged in the left bronchus during the patient's atomization process increases, the information processing module 200 adjusts the atomization particle size or the atomization flow rate based on the data representing the increase of sputum wetness in the left bronchus.

[0098] When the atomization particle size belongs to the particle size that meets the delivery to the bronchus, the information processing module 200 increases the atomization flow rate according to the preset threshold.

[0099] When the atomization particle size does not belong to the particle size that meets the delivery to the bronchus, the information processing module 200 adjusts the power of the atomization unit 320 so that the atomization particle size meets the particle size that meets the delivery to the bronchus.

[0100] The system and device involved in the present application open the collection channel of a specific part for different symptoms to obtain more accurate adjustment effect and prevent interference of signals of other parts.

[0101] Embodiment 6

[0102] This embodiment is a further improvement of the foregoing embodiments, and the repeated contents will not be described again.

[0103] The present embodiment provides an atomization system implementation method based on respiratory-drug supply dynamic coupling, which is especially suitable for drug delivery control of patients with chronic respiratory diseases. The hardware architecture of the atomization system is shown in FIG. 1 and FIG. 2, which includes three parts of the auxiliary respirator 100, the information processing module 200 and the inhalation drug delivery module 300 working cooperatively, wherein the auxiliary respirator 100 contains six-channel breathing sound collection unit 110 (as part of the breathing sound collection array) and inflatable pressure suit 120 (including clothing 121, inflatable air bag 122 and fluid supply unit 123) arranged on the chest and abdomen of the patient, the inhalation drug delivery module 300 integrates the atomization unit 320 (containing first drug liquid box 331 and second drug liquid box 332) of the double drug box structure, the information processing module 200 is connected with the breathing sound sensor through the built-in Bluetooth communication unit, and the data interaction channel is established with the cloud medical information system through the Wi-Fi module.

[0104] The system is characterized by constructing a dynamic coupling mechanism of respiratory phase monitoring and drug delivery timing control. The implementation method includes the following steps:

[0105] S1, respiratory-drug supply synchronization initialization

[0106] Under the resting state of the patient, the breathing sound collection unit 110 collects 30 seconds of breathing sound signals to calculate the initial breathing frequency f b (0) according to the breathing cycle reference value T d (0) collected under the resting state of the patient:

[0107] wherein parameter T b (0) represents the reference value of the respiratory cycle in the resting state of the patient, and the initial respiratory frequency f d (0) is converted by 60 times of the reciprocal of the above value. Exemplarily, if the reference value of the respiratory cycle in the resting state of a patient is 3.2 s, the initial respiratory frequency f d (0) is 18.75 times / min.

[0108] Then, the initial drug supply frequency f d (0) is calculated according to the initial respiratory frequency f d (0) and the synchronization coefficient a: f b (0) = a f d (0).

[0109] wherein the synchronization coefficient a is in the range of 0.9-1.1, which defines the dynamic matching range of the drug supply frequency and the respiratory frequency, and the engineering significance thereof is to balance the treatment safety and the drug delivery efficiency. Exemplarily, if the synchronization coefficient a is 1.05, the initial drug supply frequency of the above patient is 19.69 times / min.

[0110] Meanwhile, the periodic inflation frequency of the inflatable garment 120 is set to be equal to the real-time drug supply frequency f d (t), and the pipeline delay compensation amount At is calculated according to the length of the atomization pipeline and the airflow velocity, so as to ensure that the atomized particles reach the respiratory tract at the early stage of the inspiration phase of the patient. For example, for the atomization pipeline length of 1.2 m and the airflow velocity of 0.8 m / s, the pipeline delay compensation amount At is the quotient of the above two values, i.e. 1.5 s.

[0111] S2, dynamically adjusting the atomization flow and particle

[0112] In the dynamic adjustment stage, a multi-parameter closed-loop control strategy can be adopted, and the information processing module 200 analyzes the respiratory sound intensity signal S lung (t) of the middle lobe of the right lung in real time, and calculates the current atomization output flow Q(t) through a flow control equation: Q(t) = β S lung (t) f d (t).

[0113] wherein β is a sensitivity coefficient preset by the system, which can be 0.1 mL / (s mV); f d (t) is the real-time drug supply frequency, which is the initial drug supply frequency when t = 0. Exemplarily, when the initial intensity of the respiratory sound of the middle lobe of the right lung of the above patient is monitored to be 120 mV, the initial atomization output flow is calculated to be 236.3 mL / min.

[0114] According to the deposition characteristics of particles with different particle sizes, the system establishes a constraint equation of the real-time drug supply frequency and the target particle size:

[0115] wherein k1 is a particle kinetics coefficient, which physically reflects the delivery capacity of particles of a specific size per unit time, and can be taken as 200 μm 2 / minute; d p (t) is the target particle size.

[0116] Preferably, when the target particle size is selected as 5 μm, the frequency distribution instruction is generated, and the bronchial region weight γ1=0.6 and the alveolar region weight γ1=0.4 are controlled in a dual-channel cooperative manner to meet the local drug concentration requirement and the overall respiratory rhythm synchronicity. Exemplarily, when the current target particle size is 5 μm, the real-time drug supply frequency is 8 times / min, which conflicts with the initial drug supply frequency of 19.69 times / min, triggering the weight distribution, and the specific regional frequency distribution scheme is as follows:

[0117] wherein f d,bronchi is the drug supply frequency of the bronchial region; and f d,alveoli is the drug supply frequency of the alveolar region.

[0118] S3, Abnormal state intervention

[0119] An abnormal intervention stage is designed to have a wheezing sound recognition algorithm, when the bronchial respiratory sound amplitude exceeding the threshold value is detected, the frequency adjustment equation is started to generate a correction instruction:

[0120] wherein A wheeze is the abnormal bronchial respiratory sound amplitude; and A normal is the normal bronchial respiratory sound amplitude, and the negative sign of the differential term df d / dt indicates the inhibitory response mechanism of the system to the abnormal state.

[0121] Further, the inflatable garment 120 can activate a high-frequency vibration mode to assist in expectoration in response to the correction instruction, for example, to achieve forced exhalation in the manner of twice the drug supply frequency.

[0122] S4, Remote medical collaboration

[0123] The remote medical collaboration stage realizes controllable updating of treatment parameters, the information processing module 200 uploads the historical drug supply frequency sequence to the hospital information system (HIS), receives the doctor's order parameters, and executes frequency iteration operation, and implements output amplitude limiting protection in combination with the maximum safe frequency threshold.

[0124] Preferably, the system key operating parameters include a synchronization coefficient α (0.9-1.1), a pipeline delay compensation amount Δt (0.3-1.5), a target particle size d pThe weight of the inhalation route is γ0(0.3~0.5), the weight of the intranasal route is γ1(0.4~0.7), and the weight of the bronchial route is γ2(0.1~0.3). The embodiment realizes the technical effects of "time sequence accurate control" and "multi-modal regulation" by constructing a three-layer control architecture of respiratory signal feature extraction, atomization parameter dynamic matching, and remote instruction fusion.

Claims

1. Nebulization assistance device, which can be used in cooperation with an inhalation administration module (300) for providing a patient with a respiratory tract administration of a drug in a nebulized manner, characterized in that, It comprises: an assisted respirator (100) configured to be attached to the body surface of the respiratory tract region of a patient to collect the respiratory sound / pulmonary sound signals of the patient in relation to time when the patient uses it, wherein the assisted respirator (100) comprises an inflatable garment (120) worn on the body of the patient for assisting the patient in adjusting the respiratory frequency, and a respiratory sound collecting unit (110) arranged on the inflatable garment (120) for collecting the pulmonary sound / respiratory sound of the patient; an information processing module (200) for analyzing and processing the information collected by the assisted respirator (100) to generate adjustment instructions, wherein the information processing module (200) acquires the respiratory frequency of the patient based on the time sequence data of the respiratory sound collected by the respiratory sound collecting unit (110), and determines the start time of the inflatable garment (120) according to the matching condition of the respiratory frequency of the patient and the drug supply frequency of the inhalation drug delivery module (300).

2. The atomization assist device of claim 1, wherein, When the information processing module (200) determines that the respiratory frequency of the patient does not match the drug supply frequency of the inhalation drug delivery module (300), the inflatable garment (120) is turned on to assist the patient in adjusting the respiratory frequency.

3. The atomization assist device of claim 1 or 2, wherein, The inflatable garment (120) is configured as a garment (121) that can be worn on the body of the patient, the garment (121) comprising a garment front (1211), a garment back (1212), and an inflatable air bag (122) incorporated in or on the garment front (1211), the inflatable air bag (122) being in communication with a fluid supply unit (123).

4. The atomization assist device of any of claims 1-3, wherein When the inflatable garment (120) is turned on, the fluid supply unit (123) can inflate and deflate the inflatable air bag (122) of the garment (121) at the same frequency as the drug supply frequency of the inhalation drug delivery module (300).

5. The atomization assist device of any of claims 1-4, wherein The garment front (1211) and / or the garment back (1212) comprises a recess configured to be pressed against the body surface of the patient for placing the respiratory sound collecting unit (110).

6. An atomization system characterized by, It comprises: an inhalation drug delivery module (300) configured to provide a patient with a drug for administration through the respiratory tract in a nebulization manner, which is provided with a flow detection device to acquire the drug flow data in relation to time when the patient uses it; an assisted respirator (100) configured to be attached to the body surface of the respiratory tract region of a patient to collect the respiratory sound / pulmonary sound signals of the patient in relation to time when the patient uses it; an information processing module (200) for generating instructions for adjusting the inhalation drug delivery module (300) based on the information collected by the assisted respirator (100), based on the correlation analysis of the respiratory sound / pulmonary sound signals and the drug flow data collected by the assisted respirator (100), the information processing module (200) generates adjustment instructions for the nebulization position, breathing mode and / or nebulization drug ratio.

7. The atomization system of claim 6, wherein, The information processing module (200) is configured to: generate nebulization flow rate adjustment instructions related to the adjustment of the respiratory frequency of the patient based on the frequency of the respiratory sound / pulmonary sound signals collected by the assisted respirator (100).

8. The atomizing system of claim 6 or 7, wherein The information processing module (200) is configured to: Generate the atomization particle adjustment instruction related to the change of the patient's sputum symptom based on the intensity of the respiratory sound / pulmonary sound signal collected by the auxiliary respirator (100).

9. The atomising system according to any one of claims 6 to 8, wherein The information processing module (200) is configured to: Generate the adjustment instruction to alleviate the abnormal symptoms of the patient caused by the atomization based on the abnormal change of the respiratory sound / pulmonary sound signal collected by the auxiliary respirator (100).

10. An atomising system according to any one of claims 6 to 9, wherein The information processing module (200) is configured to: Connect with the remote medical care end, and when the remote medical care end receives the respiratory sound / pulmonary sound signal collected by the auxiliary respirator (100) of the patient for a single time or multiple times, control the inhalation drug delivery module (300) to adjust the drug ratio of the patient based on the drug ratio instruction sent by the remote medical care end.

11. The atomising system according to any one of claims 6 to 10, wherein The auxiliary respirator (100) comprises a respiratory sound collection unit (110) capable of collecting the respiratory sound of the upper respiratory tract and the lung of the patient.

12. The atomizing system according to any one of claims 6 to 11, characterized in that The auxiliary respirator (100) further comprises an inflatable garment (120) for assisting the patient to adjust the respiratory frequency, wherein the inflatable garment (120) is configured as a garment (121) capable of being worn on the body of the patient, the garment (121) comprises a garment front surface (1211), a garment back surface (1212), and an inflatable air bag (122) incorporated at least in or on the garment back surface (1212), and the garment front surface (1211) and / or the garment back surface (1212) comprises a recess configured to be pressed against the body surface of the patient to place the respiratory sound collection unit (110).

13. An atomising system according to any one of claims 6 to 12, wherein When the inflatable air bag (122) is inflated to press the garment (121) worn on the body surface of the patient, the respiratory sound collection unit (110) placed in the recess can at least collect the bronchial breath sound, alveolar breath sound, and / or bronchial alveolar breath sound of the patient.

14. The atomizing system according to any one of claims 6 to 13, characterized in that The inhalation drug delivery module (300) comprises a driving unit (310), a drug liquid box (330) adjusted by the driving unit (310), and an atomization unit (320) for making the drug liquid into aerosol, wherein the driving unit (310) comprises a connector assembly arranged between the drug liquid box (330) and the atomization unit (320), the connector assembly comprises a needle and a liquid suction pump, and the needle can pierce a medicine bottle clamped in the drug liquid box (330) and make the drug liquid in the medicine bottle flow into the atomization unit (320) under the action of the liquid suction pump under the adjustment of the information processing module (200).

15. The atomising system according to any one of claims 6 to 14, wherein The drug liquid box (330) comprises a first drug liquid box (331) and a second drug liquid box (332), and the first drug liquid box (331) and the second drug liquid box (332) can be individually adjusted by the driving unit (310) for drug delivery.

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