Polymer material and ophthalmic lens

Abstract

According to the present invention, provided are: a polymer material in which a polymer component including a constituent unit derived from a monomer component and a polysaccharide component are composited, wherein the monomer component includes a water-soluble monomer, and the polysaccharide component does not have a polymerizable functional group; and an ophthalmic lens including the polymer material.

Description

Polymer Material and Ophthalmic Lens

[0001] The present invention relates to a polymer material and an ophthalmic lens.

[0002] The surface of the cornea is usually covered with a tear film. The tear film has a liquid layer containing water, mucin, etc. and an oil layer in this order from the corneal side, and plays roles such as supplying nutrition to the cornea, preventing infection, and preventing dryness.

[0003] When a contact lens is worn on the corneal surface, the structure of the tear film may change, and the amount of tears may decrease or the tear film may become unstable, which may lead to a decrease in wearing comfort and a risk of dry eye. Therefore, a contact lens having a high affinity for water and mucin and having a small influence on the tear film is desirable.

[0004] In response to the above demand, attention has been paid to its high water retention, lubricity, etc., and the use of polysaccharides has been studied. For example, producing a contact lens using hyaluronic acid into which a polymerizable functional group has been introduced (Patent Document 1), and attaching hyaluronic acid to the surface layer portion of a contact lens using a preservation solution containing hyaluronic acid (Patent Document 2) have been proposed.

[0005] Japanese Unexamined Patent Application Publication No. 2013 - 56955, WO2006 / 085351A1

[0006] It is unclear to what extent the hyaluronic acid into which the above polymerizable functional group has been introduced maintains the original properties of hyaluronic acid. Also, when using a preservation solution containing hyaluronic acid, the amount of hyaluronic acid attached to the contact lens is limited. Further, when the wearing time becomes long, much of the attached hyaluronic acid may be released, and the effect may be weakened.

[0007] The main object of the present invention is to provide a polymer material containing a non - polymerizable polysaccharide component and capable of favorably exhibiting the characteristics (for example, lubricity) of the polysaccharide component.

[0008] [1] According to one aspect of the present invention, a polymer material is provided which is a composite of a polymer component containing constituent units derived from a monomer component and a polysaccharide component, wherein the monomer component contains a water-soluble monomer and the polysaccharide component does not have polymerizable functional groups. [2] In the polymer material described in [1] above, the polysaccharide component may contain at least one selected from hyaluronic acid or a salt thereof. [3] In the polymer material described in [1] or [2] above, the weight-average molecular weight of the polysaccharide component may be 10,000 to 2,500,000. [4] In the polymer material described in any of [1] to [3] above, the water-soluble monomer may contain a water-soluble monofunctional monomer. [5] In the polymer material described in [4] above, the content of the water-soluble monofunctional monomer in the monomer component may be 25% to 100% by mass. [6] In the polymer material described in [4] or [5] above, the water-soluble monofunctional monomer may include a first water-soluble monofunctional monomer having a hydroxyl group, and the first water-soluble monofunctional monomer may include at least one selected from a first water-soluble monofunctional monomer A having two or more hydroxyl groups and a first water-soluble monofunctional monomer B having one hydroxyl group. [7] In the polymer material described in any of [4] to [6] above, the water-soluble monofunctional monomer may further include a second water-soluble monofunctional monomer that does not have a hydroxyl group. [8] In the polymer material described in [7] above, the content of the second water-soluble monofunctional monomer in the monomer component may be 1% by mass to 75% by mass. [9] In the polymer material described in any of [6] to [8] above, the first water-soluble monofunctional monomer may include the first water-soluble monofunctional monomer A and the first water-soluble monofunctional monomer B.

[10] In the polymer material described in [9] above, the content of the first water-soluble monofunctional monomer A in the monomer component may be 1% by mass to 99% by mass, and the content of the first water-soluble monofunctional monomer B in the monomer component may be 1% by mass to 99% by mass.

[11] In the polymer material according to any one of [6] to

[10] above, the first water-soluble monofunctional monomer may include glycerol monomethacrylate as the first water-soluble monofunctional monomer A.

[12] In the polymer material according to any one of [6] to

[11] above, the first water-soluble monofunctional monomer may include at least one selected from hydroxyethyl methacrylate and hydroxyethyl acrylamide as the first water-soluble monofunctional monomer B.

[13] In the polymer material according to any one of [4] to

[12] above, the water-soluble monomer may further include a water-soluble crosslinked monomer.

[14] In the polymer material according to

[13] above, the content of the water-soluble crosslinked monomer in the monomer component may be 0.1% by mass to 75% by mass.

[15] The polymer material described in any of [1] to

[14] above may be obtained by polymerizing a polymerizable composition containing the monomer component, the polysaccharide component, and a solvent, wherein the solvent may contain water, and the content of water in the total content A of the monomer component, the polysaccharide, and the solvent may be 24% by mass or more.

[16] In the polymer material described in

[15] above, the content of the polysaccharide component in the total content A may be 1% by mass or less.

[17] In the polymer material described in

[15] or

[16] above, the polymerizable composition may further contain a water-soluble polymerization initiator.

[18] The water content of the polymer material described in any of [1] to

[17] above may be 30% or more and 85% or less.

[19] According to another aspect of the present invention, an eye lens is provided comprising the polymer material described in any of [1] to

[18] above.

[0009] According to the present invention, by polymerizing a polymerizable composition containing a monomer component including a water-soluble monomer and a non-polymerizable polysaccharide component, a polymer material can be obtained in which a polymer component having structural units derived from the monomer component and the polysaccharide component are compounded, thereby achieving both excellent lubricity and transparency.

[0010] In this specification, "monomer" means a polymerizable compound having one or more polymerizable functional groups. "Monofunctional monomer" means a polymerizable compound having only one polymerizable functional group. "Crosslinked monomer" means a polymerizable compound having two or more polymerizable functional groups.

[0011] Examples of the polymerizable functional groups mentioned above include (meth)acryloyl group, (meth)acrylamide group, vinyl group, allyl group, etc. Here, "(meth)" means any methyl substitution. Therefore, "(meth)acryloyl" means methacryloyl and / or acryloyl. The same applies to other notations such as "(meth)acrylic".

[0012] In this specification, "water-soluble" means that the solubility in water at 20°C [g / 100g water] is 10 or higher. A water-soluble substance may have a solubility of, for example, 10 or higher or 20 or higher. For example, if a substance and water are mixed at 1 atmosphere and 20°C in a weight ratio of 1:10 (former:latter) and allowed to stand for 1 hour, and a solution with a clear and uniform appearance is obtained, then the substance can be considered a water-soluble substance.

[0013] In this specification, the "~" symbol used to indicate a numerical range includes its upper and lower limits.

[0014] The following describes embodiments of the present invention, but the present invention is not limited to these embodiments.

[0015] According to one aspect of the present invention, a polymer material is provided in which a polymer component containing constituent units derived from a monomer component is compounded with a polysaccharide component, wherein the monomer component includes a water-soluble monomer, and the polysaccharide component does not have polymerizable functional groups. Therefore, the polymer material is a polymer material in which a polymer component containing constituent units derived from a water-soluble monomer is compounded with a polysaccharide component that does not have polymerizable functional groups, and the two polymer components may have a structure in which they are intricately intertwined.

[0016] The light transmittance of the above polymer material at wavelengths of 380 nm to 780 nm may be, for example, 90% or more, preferably 92% or more, and more preferably 95% or more. The above light transmittance can be measured in accordance with ISO 18369-3.

[0017] The tensile modulus (at 20°C) of the above polymer material may be, for example, 0.05 MPa or higher, preferably 0.1 MPa or higher, and more preferably 0.15 MPa or higher. The above tensile modulus may be, for example, 2.0 MPa or lower, or 1.5 MPa or lower.

[0018] The water content of the above polymer material is, for example, 30% or more, preferably 35% or more, more preferably 40% or more, and may be 50% or more or 60% or more. The above water content may be, for example, 85% or less or 80% or less.

[0019] The oxygen permeability coefficient (Dk) of the above polymer material may be, for example, 10 Barre or more, preferably 12 Barre or more, and more preferably 14 Barre or more.

[0020] The coefficient of dynamic friction of the above polymer material may be, for example, 0.001 to 0.05, preferably 0.001 to 0.03, when the sliding speed (V) = 1.0 mm / s. The coefficient of dynamic friction may be, for example, 0.001 to 0.05, preferably 0.001 to 0.03, when V = 2.5 mm / s.

[0021] The contact angle of the above polymer material is, for example, 120° or less, preferably 100° or less, more preferably 90° or less, and may also be 75° or less.

[0022] Because the above polymer material has excellent transparency and lubricity, it can be suitably used in ophthalmic lenses such as contact lenses, intraocular lenses, artificial corneas, corneal onlays, and corneal inlays.

[0023] The polymer material described above can be obtained by polymerizing a polymerizable composition containing the monomer component and the polysaccharide component. The polymerizable composition may further contain additives such as polymerization initiators and solvents.

[0024] A. Monomer component The monomer component includes a water-soluble monomer as described above. The monomer component preferably includes a water-soluble monofunctional monomer and may further include a crosslinked monomer. The crosslinked monomer can function as a crosslinking agent. The crosslinked monomer may be water-soluble or water-insoluble. In one embodiment, the monomer component includes a water-soluble monofunctional monomer and a water-soluble crosslinked monomer.

[0025] A-1. Water-soluble monofunctional monomers Any suitable water-soluble monomer having one polymerizable functional group in the molecule can be used as the water-soluble monofunctional monomer. The solubility of the water-soluble monofunctional monomer in water at 20°C may be, for example, 25 or more or 30 or more.

[0026] The ClogP value of the water-soluble monofunctional monomer is preferably 1.3 or less, and more preferably 0.7 or less. The above ClogP value may be, for example, -0.6 or more. Here, "logP value" is the logarithm of the partition coefficient of 1-octanol / water, and is known as a parameter that represents the hydrophilicity or hydrophobicity of the molecule. "ClogP value" is the logP value calculated by calculation. The ClogP value can be calculated using the fragment method described in the literature (C. Hansch and A. Leo, "Substition Constants for Correlation Analysis in Chemistry and Biology" (John Wiley & Sons, New York, 1969)). The calculation of ClogP values ​​using the fragmentation method can be performed using the commercially available software package Chem Draw (CambridgeSoft Corporation, USA).

[0027] The water-soluble monofunctional monomer typically includes a first water-soluble monofunctional monomer having a hydroxyl group. The first water-soluble monofunctional monomer may exhibit excellent compatibility with polysaccharide components in polymerizable compositions. The water-soluble monofunctional monomer may further include a second water-soluble monofunctional monomer that does not have a hydroxyl group.

[0028] A-1-1. First water-soluble monofunctional monomer As the first water-soluble monofunctional monomer, a first water-soluble monofunctional monomer A having two or more hydroxyl groups and a first water-soluble monofunctional monomer B having only one hydroxyl group can be used individually or in combination.

[0029] In one embodiment, the first water-soluble monofunctional monomer comprises the first water-soluble monofunctional monomer A, preferably comprising both the first water-soluble monofunctional monomer A and the first water-soluble monofunctional monomer B. According to such an embodiment, the effect of improving strength can be suitably obtained.

[0030] As the first water-soluble monofunctional monomer A, any water-soluble monofunctional monomer having two or more hydroxyl groups can be used. The number of hydroxyl groups in the first water-soluble monofunctional monomer A may be, for example, 2 to 8, preferably 2 to 6. The hydroxyl group equivalent (molecular weight / number of hydroxyl groups) of the first water-soluble monofunctional monomer A may be, for example, 50 to 4000, preferably 70 to 2000.

[0031] Examples of the first water-soluble monofunctional monomer A include polyhydric alcohols such as linear or branched polyglycerols with a polymerizable functional group introduced at one of their terminal ends, polyhydroxyalkyl (meth)acrylates having a C2-C5, preferably C3-C4, alkyl group with two or more hydroxyl groups introduced, and polyhydroxyalkyl (meth)acrylamides having a C2-C5, preferably C3-C4, alkyl group with two or more hydroxyl groups introduced. The first water-soluble monofunctional monomer A can be used alone or in combination of two or more.

[0032] Specific examples of the first water-soluble monofunctional monomer A include dihydroxypropyl (meth)acrylate (also referred to as "glycerol mono(meth)acrylate") and 3-hydroxy-2,2-bis(hydroxymethyl)propyl (meth)acrylate (also referred to as "pentaerythritol mono(meth)acrylate"). Among these, glycerol mono(meth)acrylate is preferred.

[0033] Examples of the first water-soluble monofunctional monomer B include hydroxyalkyl (meth)acrylate having an alkyl group having 1 to 5 carbon atoms, preferably 2 to 4 carbon atoms; hydroxyalkyl (meth)acrylamide having an alkyl group having 1 to 5 carbon atoms, preferably 2 to 4 carbon atoms; and polyalkylene glycol mono(meth)acrylate having an alkylene group having 2 to 3 carbon atoms. The first water-soluble monofunctional monomer B can be used alone or in combination of two or more types.

[0034] Specific examples of the first water-soluble monofunctional monomer B include hydroxyethyl (meth)acrylate, hydroxypropyl (meth)acrylate, hydroxybutyl (meth)acrylate, hydroxymethyl (meth)acrylamide, hydroxyethyl (meth)acrylamide, hydroxypropyl (meth)acrylamide, hydroxybutyl (meth)acrylamide, diethylene glycol mono(meth)acrylate, triethylene glycol mono(meth)acrylate, polyethylene glycol mono(meth)acrylate, and the like. Among these, hydroxyethyl (meth)acrylate and hydroxyethyl (meth)acrylamide are preferred.

[0035] In one embodiment, a first water-soluble monofunctional monomer B having a nitrogen atom (for example, a first water-soluble monofunctional monomer B having an amide group) may be used in combination with at least one selected from the first water-soluble monofunctional monomer A and the first water-soluble monofunctional monomer B that does not contain a nitrogen atom. In such embodiments, a transparent polymerizable composition (and consequently a transparent polymer material) can be suitably obtained even when a second water-soluble monofunctional monomer is not used.

[0036] A-1-2. Second water-soluble monofunctional monomer As the second water-soluble monofunctional monomer, monomers that do not have a hydroxyl group and have hydrophilic structures other than hydroxyl groups (for example, amide group, amino group, carboxyl group, alkoxy group, ester bond, ether bond, thioether bond, disulfide bond, cyano group, sulfo group, phosphate group, phosphoryl group, quaternary ammonium salt, etc.) can be used. By using the second water-soluble monofunctional monomer, an effect of improving strength can be suitably obtained. The second water-soluble monofunctional monomer can be used alone or in combination of two or more types.

[0037] In one embodiment, the second water-soluble monofunctional monomer may have a nitrogen atom. By using the second water-soluble monofunctional monomer having a nitrogen atom in combination with the first water-soluble monofunctional monomer having a hydroxyl group, an effect of improving strength can be suitably obtained.

[0038] Specific examples of the second type of water-soluble monofunctional monomer include N-monoalkyl(meth)acrylamides such as (meth)acrylamide, N-monomethyl(meth)acrylamide, N-monoethyl(meth)acrylamide, and N-monopropyl(meth)acrylamide; N,N-dialkyl(meth)acrylamides such as N,N-dimethyl(meth)acrylamide, N,N-diethyl(meth)acrylamide, and N,N-dipropyl(meth)acrylamide; N,N-dialkylaminoethyl(meth)acrylates such as N,N-dimethylaminoethyl(meth)acrylate; N,N-dialkylaminoalkyl(meth)acrylamides such as N,N-dimethylaminopropyl(meth)acrylamide and N,N-diethylaminopropyl(meth)acrylamide; and carbon number(meth)acrylates such as methoxyethyl(meth)acrylate. Examples include alkoxyalkyl (meth)acrylates having 3 or fewer alkoxyalkyl groups; N-vinyl lactams such as N-vinylpyrrolidone, N-vinylpiperidone, and N-vinylcaprolactam; α-methylene lactams such as 1-methyl-3-methylene-2-pyrrolidinone; monomers having quaternary ammonium salts such as [2-[(meth)acryloyloxy]ethyl]trimethylammonium chloride, [3-(acrylamidopropyl]trimethylammonium chloride, and N-(2-acryloyloxyethyl)-benzyl-N,N-dimethylammonium chloride; 2-methacryloyloxyethyl phosphorylcholine; 2-acrylamido-2-methylpropanesulfonic acid; (meth)acrylic acid; maleic anhydride; maleic acid; maleic acid derivatives; fumaric acid; fumaric acid derivatives; and the like. Among these, monomers having an amide group such as N,N-dialkyl(meth)acrylamide, N-vinyl lactam, and α-methylene lactam, and monomers having an amino group such as N,N-dialkylaminoethyl(meth)acrylate and N,N-dialkylaminoalkyl(meth)acrylamide are preferred, and 1-methyl-3-methylene-2-pyrrolidinone, N-vinylpyrrolidone, N,N-dimethyl(meth)acrylamide, and N,N-dimethylaminoethyl(meth)acrylate are more preferred.

[0039] A-2. Water-soluble crosslinked monomers The number of polymerizable functional groups in a water-soluble crosslinked monomer is, for example, 2 to 6, and may be 2, 3, or 4. The polymerizable functional group equivalent (molecular weight / number of polymerizable functional groups) of the water-soluble monomer may be, for example, 40 to 6000, preferably 60 to 5000. The solubility of the water-soluble crosslinked monomer in water at 20°C may be, for example, 25 or more or 30 or more.

[0040] Examples of water-soluble crosslinked monomers include polyalkylene glycol di(meth)acrylates, polyfunctional (meth)acrylates such as those obtained by adding a mono- or polyalkylene glycol to the hydroxyl group of a polyhydric alcohol and introducing (meth)acryloyl groups to two or more of its terminals, and polyfunctional (meth)acrylamides such as those having one or more alkylene chains containing oxygen atoms in the chain and introducing (meth)acrylamide groups to two or more of the terminals of the alkylene chains. The alkylene groups in the above water-soluble crosslinked monomers are preferably alkylene groups having 1 to 4 carbon atoms, more preferably 2 to 3 carbon atoms. Water-soluble crosslinked monomers can be used individually or in combination of two or more.

[0041] Specific examples of water-soluble crosslinked monomers include those obtained by adding mono- or polyethylene glycol to the hydroxyl group of polyhydric alcohols such as polyethylene glycol di(meth)acrylate, glycerol, pentaerythritol, and sorbitol, and introducing polymerizable functional groups to two or more of its ends. For example, sorbitol 6EO-modified acrylate (2.5-functional) is sold under the product name "Aronics M-926" (manufactured by Toagosei Co., Ltd.).

[0042] A-3. Water-insoluble monomers The monomer component may contain water-insoluble monomers, specifically, water-insoluble monofunctional monomers and / or crosslinking monomers, as long as the effects of the present invention can be obtained. Examples of the water-insoluble monofunctional monomers include alkyl (meth)acrylates in which the alkyl group has 1 to 6 carbon atoms, preferably 1, 2, or 3 carbon atoms, and alkoxyalkyl (meth)acrylates having an alkoxyalkyl group with 4 to 6 carbon atoms such as ethoxyethyl (meth)acrylate, N,N-diethylaminoethyl (meth)acrylate, N,N-dimethylaminopropyl (meth)acrylate, and other N,N-dialkylaminoalkyl (meth)acrylates. Examples of the water-insoluble crosslinking monomers include alkanediol di(meth)acrylates in which the alkyl group has 2 to 10 carbon atoms, alkylene glycol di(meth)acrylates in which the alkylene group has 2 to 10 carbon atoms, alkoxy(meth)acrylates having 3 to 6 carbon atoms with an allyl group, N,N'-methylenebis(meth)acrylamide, and the like. The water-insoluble monomers can be used alone or in combination of two or more. The solubility of the water-insoluble monomers in water at 20 °C is typically less than 10, and can be, for example, 1 or more or 2 or more.

[0043] A-4. Content ratio of monomer component When the total content of the monomer component, polysaccharide component, and solvent in the polymerizable composition is defined as "total content A", the content ratio of the monomer component in the total content A can be, for example, 49% by mass to 75% by mass, preferably 54% by mass to 74% by mass, more preferably 59% by mass to 73% by mass.

[0044] The content ratio of the water-soluble monofunctional monomer in the monomer component is, for example, 25% by mass or more, preferably 30% by mass or more, more preferably 35% by mass or more, and can be 50% by mass or more, 60% by mass or more, 70% by mass or more, 80% by mass or more, or 90% by mass or more, and is, for example, 100% by mass or less, preferably 95% by mass or less.

[0045] The content ratio of the first water-soluble monofunctional monomer in the monomer component can be, for example, 25% by mass to 100% by mass, preferably 30% by mass to 95% by mass, more preferably 35% by mass to 90% by mass.

[0046] When the water-soluble monofunctional monomer includes the first water-soluble monofunctional monomer A and the first water-soluble monofunctional monomer B, the content ratio of the first water-soluble monofunctional monomer A in the monomer component can be, for example, 1% by mass to 99% by mass, preferably 5% by mass to 95% by mass, and the content ratio of the first water-soluble monofunctional monomer B can be, for example, 1% by mass to 99% by mass, preferably 5% by mass to 95% by mass. Also, the content mass ratio (the former: the latter) of the first water-soluble monofunctional monomer A and the first water-soluble monofunctional monomer B can be, for example, 1:99 to 99:1, preferably 3:97 to 97:3.

[0047] The content ratio of the second water-soluble monofunctional monomer in the monomer component can be, for example, 1% by mass to 75% by mass, preferably 3% by mass to 70% by mass.

[0048] When the water-soluble monofunctional monomer includes the first water-soluble monofunctional monomer and the second water-soluble monofunctional monomer, the content mass ratio (the former: the latter) can be, for example, 25:75 to 99:1, preferably 40:60 to 95:5.

[0049] The content ratio of the crosslinking monomer in the monomer component is, for example, 75% by mass or less, preferably 70% by mass or less, more preferably 65% by mass or less, and can be 50% by mass or less, 40% by mass or less, 30% by mass or less, 20% by mass or less, or 10% by mass or less, and can be, for example, 0.1% by mass or more, preferably 0.5% by mass or more, more preferably 1% by mass or more, and can be 3% by mass or more or 5% by mass or more. As the crosslinking monomer, either one of the water-soluble crosslinking monomer and the water-insoluble crosslinking monomer can be used alone or both can be used in combination.

[0050] The content of water-insoluble monomers in the monomer component (total content of water-insoluble monofunctional monomers and water-insoluble crosslinked monomers) is not limited as long as the effects of the present invention are obtained, and may be, for example, 20% by mass or less, preferably 15% by mass or less, and more preferably 0% to 10% by mass. The content of water-insoluble crosslinked monomers in the monomer component may be, for example, 20% by mass or less, preferably 0% to 10% by mass. The content of water-insoluble monofunctional monomers in the monomer component may be, for example, 20% by mass or less, preferably 10% by mass or less, and more preferably 0% to 5% by mass.

[0051] In one embodiment, the monomer component may contain 24% to 98.9% by mass of a first water-soluble monofunctional monomer comprising a first water-soluble monofunctional monomer A and a first water-soluble monofunctional monomer B in a mass ratio of 1:99 to 99:1, 1% to 75% by mass of a second water-soluble monofunctional monomer, and 0.1% to 75% by mass of a crosslinked monomer (preferably a water-soluble crosslinked monomer). For example, it may contain 27% to 96.5% by mass of a first water-soluble monofunctional monomer comprising a first water-soluble monofunctional monomer A and a first water-soluble monofunctional monomer B in a mass ratio of 3:97 to 97:3, 3% to 70% by mass of a second water-soluble monofunctional monomer, and 0.5% to 70% by mass of a crosslinked monomer (preferably a water-soluble crosslinked monomer). Specific examples of monomer components include a monomer component containing 50% to 80% by mass of a first water-soluble monofunctional monomer comprising a first water-soluble monofunctional monomer A and a first water-soluble monofunctional monomer B in a mass ratio of 5:95 to 95:5, 10% to 30% by mass of a second water-soluble monofunctional monomer, and 5% to 20% by mass of a crosslinked monomer (preferably a water-soluble crosslinked monomer).

[0052] In one embodiment, the monomer component is substantially free of silicon-containing monomers. The content of silicon-containing monomers in the monomer component may be, for example, 0.5% by mass or less, preferably 0.3% by mass or less, and more preferably 0% to 0.1% by mass.

[0053] B. Polysaccharide Components Examples of polysaccharide components include hyaluronic acid, chondroitin sulfate, xanthan gum, tamarind seed gum, locust bean gum, alginic acid, guar gum, cationized guar gum, hydroxypropyl guar gum, carrageenan, gellan gum, gum arabic, dextran, pectin, karaya gum, agarose, succinoglycan, pullulan, tara gum, glucomannan, psyllium seed gum, agar, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, methylcellulose, cellulose nanofiber, and other polysaccharides and their salts. Among these, hyaluronic acid and its salts are preferred. The salts can be any biocompatible salts, such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts. One type of polysaccharide component may be used alone, or two or more types may be used in combination.

[0054] Hyaluronic acid is a linear high-molecular-weight polysaccharide whose constituent units are disaccharides formed by a β1→4 linkage between N-acetylglucosamine and glucuronic acid. In addition to hyaluronic acid and its salts, hyaluronic acid derivatives and their salts can also be used as hyaluronic acid components. Examples of hyaluronic acid derivatives include acetylated hyaluronic acid, in which a hydroxyl group is replaced with an acetyl group; carboxymethyl hyaluronic acid, in which a carboxyl group is introduced to a hydroxyl group via a methyl group; alkylated hyaluronic acid, in which an alkyl group is introduced via a glycerol skeleton; and hydroxypropyltrimonium hyaluronate, in which a cationization site is introduced.

[0055] The weight-average molecular weight of the polysaccharide component is, for example, 10,000 to 2,500,000, preferably 50,000 to 2,400,000, and more preferably 100,000 to 2,300,000. If the weight-average molecular weight is too low, the retention of the polysaccharide component in the polymer material may decrease. If the weight-average molecular weight is too high, it may be difficult to adjust the viscosity of the polymerizable composition to a desired range. The weight-average molecular weight of the polysaccharide component can be determined by performing liquid chromatography analysis and applying the analysis results to a calibration curve created using multiple polysaccharides (reference substances) with known molecular weights.

[0056] The proportion of polysaccharide components in the total content A of the polymerizable composition is, for example, 1.3% by mass or less, preferably 1% by mass or less, and may be 0.1% to 0.8% by mass, 0.15% to 0.6% by mass, or 0.2% to 0.5% by mass.

[0057] The content ratio of the polysaccharide component in the polymerizable composition may be, for example, 0.1 to 1.8 parts by mass, preferably 0.2 to 1.7 parts by mass, and more preferably 0.3 to 1.6 parts by mass, per 100 parts by mass of the monomer component.

[0058] The polysaccharide component content in the polymerizable composition may be, for example, 0.1 to 6 parts by mass, preferably 0.2 to 5 parts by mass, and more preferably 0.3 to 4 parts by mass, per 100 parts by mass of solvent.

[0059] C. The solvent typically contains water. By mixing polysaccharide components with water-soluble monomers and the like in a water-containing solvent, the solubility of each component, such as the polysaccharide components, can be ensured, and a transparent polymerizable composition can be suitably obtained.

[0060] The water content in the total content A of the polymerizable composition is typically 23.7% by mass or more, for example 24% by mass or more, preferably 25% by mass or more, more preferably 27% by mass or more, and may be 28% by mass or more. When the water content in the polymerizable composition is within the above range, a transparent polymerizable composition can be more preferably obtained.

[0061] In one embodiment, when the content of polysaccharide components in the total content A of the polymerizable composition is X by mass and the content of water is Y by mass, X and Y can satisfy the relationship Y ≥ 10X + 18, preferably Y ≥ 10X + 20, and more preferably Y ≥ 10X + 22 (where Y ≥ 24). When X and Y satisfy the above relationship, a transparent polymerizable composition can be more preferably obtained.

[0062] The solvent may further contain a water-miscible organic solvent, insofar as the effects of the present invention are obtained. Examples of water-miscible organic solvents include C1-C3 alcohols, acetone, dimethylformamide, dimethyl sulfoxide, and acetonitrile. The content of the water-miscible organic solvent in the solvent may be, for example, 20% by mass or less, preferably 15% by mass or less, and more preferably 0% to 10% by mass.

[0063] The solvent content in the total content A of the polymerizable composition is typically 23.7% by mass or more, for example 24% by mass or more, preferably 25% by mass or more, more preferably 27% by mass or more, and may be 28% by mass or more. The above content may be, for example, 50% by mass or less or 40% by mass or less. In one embodiment, when the content of polysaccharide components in the total content A of the polymerizable composition is X% by mass and the content of solvent is Z% by mass, X and Z may satisfy the relationship 50 ≥ Z ≥ 10X + 18, preferably 40 ≥ Z ≥ 10X + 20, and more preferably 38 ≥ Z ≥ 10X + 22 (where Z ≥ 24). If the solvent content is high, the density of the resulting polymer material in the hydrated state will be low, and the polysaccharide retention may decrease.

[0064] D. The additive polymerizable composition may further contain a polymerization initiator and any other suitable additives. The polymerization initiator and other additives are also preferably water-soluble.

[0065] Depending on the polymerization method, photopolymerization initiators and / or thermal polymerization initiators may be used as polymerization initiators, and photopolymerization initiators are preferably used. Examples of water-soluble photopolymerization initiators include carbonyl compounds such as aromatic ketones, acylphosphine oxide compounds, and polymer-type photopolymerization initiators.

[0066] Water-soluble thermal polymerization initiators are available commercially. Alternatively, water-soluble thermal polymerization initiators may be synthesized according to previously reported methods. Examples of commercially available water-soluble thermal polymerization initiators include water-soluble azo polymerization initiators, such as V-050, V-501, VA-044, VA-057, VA-061, and VA-086 from Fujifilm Wako Pure Chemical Industries, Ltd.

[0067] Water-soluble photopolymerization initiators are available commercially. Alternatively, water-soluble photopolymerization initiators may be synthesized according to previously reported methods. Examples of commercially available water-soluble photopolymerization initiators include LAP from Tokyo Chemical Industry Co., Ltd. and Omnirad® 2959 from IGM Resins, Inc.

[0068] The amount of polymerization initiator in the polymerizable composition may be, for example, 0.001 to 2 parts by mass, preferably 0.01 to 1 part by mass, based on 100 parts by mass of the total content of monomer components and polysaccharide components.

[0069] Other additives mentioned above include those conventionally used in ophthalmic lenses, such as cooling agents, viscosity modifiers, surfactants, dyes, UV absorbers, and UV-absorbing dyes. These other additives can be used individually or in combination of two or more.

[0070] The content of other additives in the polymerizable composition may be, for example, 0.01 to 3 parts by mass, preferably 0.01 to 1 part by mass, based on 100 parts by mass of the total content A.

[0071] [Polymerization Method] Any suitable polymerization method can be used to polymerize the above polymerizable composition. For example, photopolymerization or thermal polymerization may be applied.

[0072] In photopolymerization, the wavelength of light irradiated onto the polymerizable composition is appropriately set according to the type of photopolymerization initiator, the composition of the polymerizable composition, etc. The light intensity and irradiation time are appropriately set according to the composition of the polymerizable composition, etc. The light intensity is preferably 0.1 mW / cm². ２ ~100 mW / cm ２ The irradiation time is preferably one minute or more. Light of different illuminances may be irradiated in stages.

[0073] In thermal polymerization, the heating temperature and heating time when heating the polymerizable composition are appropriately set according to the type of thermal polymerization initiator, the composition of the polymerizable composition, etc. The heating temperature is preferably 50°C to 150°C, more preferably 60°C to 140°C. The heating time is preferably 10 minutes to 120 minutes, more preferably 20 minutes to 60 minutes.

[0074] When polymer materials are used for ophthalmic lenses such as contact lenses, the ophthalmic lenses can be manufactured, for example, by the casting method. In the casting method, a mold is used to form voids corresponding to the shape of the ophthalmic lens, and the polymerizable composition is filled into these voids and polymerized.

[0075] Polymerization using the above molding method can yield a polymer material having a desired ophthalmic lens shape. The obtained polymer material may be subjected to mechanical processing such as cutting and polishing as needed. Cutting may be performed over the entire surface of one or both surfaces of the polymer material, or on a portion of one or both surfaces of the polymer material. The polymer material may also be subjected to surface modification treatments such as low-temperature plasma treatment, atmospheric pressure plasma treatment, or corona discharge treatment for the purpose of surface modification.

[0076] Preferably, the polymer material removed from the mold is subjected to an elution treatment to elute unreacted monomer components and reduce their remaining amount. The elution treatment is carried out, for example, by immersing the polymer material in water or an organic solvent (e.g., ethanol, isopropanol) or a mixture thereof as the elution solvent. The immersion time is, for example, 5 minutes to 10 hours, preferably 10 minutes to 5 hours. The immersion temperature is, for example, 4°C to 40°C, preferably 20°C to 30°C. The elution treatment may be carried out, for example, 1 to 8 times, preferably 2 to 6 times, using the same elution solvent or different elution solvents.

[0077] The polymer material after elution treatment can be subjected to sterilization in a sealed package along with the preservative solution. Sterilization methods include heat treatment at 120°C to 126°C for 15 to 25 minutes (e.g., autoclaving) and gamma irradiation. Sterilization may be performed alone or in combination of two or more methods. As the preservative solution, any solution conventionally known for the manufacture of contact lens packages can be appropriately selected.

[0078] The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples. Unless otherwise specified, "parts" and "%" in the examples and comparative examples are based on mass.

[0079] The compounds used in the following experimental examples are listed below. <Polysaccharide components> Sodium hyaluronate Mw = 850,000 to 1,200,000 <First water-soluble monofunctional monomer A> GMA (glycerol monomethacrylate) <First water-soluble monofunctional monomer B> HEMA (hydroxyethyl methacrylate) HEAA (hydroxyethyl acrylamide) <Second water-soluble monofunctional monomer> NMMP (1-methyl-3-methylene-2-pyrrolidinone) DMAA (N,N-dimethylacrylamide) NVP (N-vinyl-2-pyrrolidone) DMAEMA (N,N-dimethylaminoethyl methacrylate) <Water-soluble crosslinked monomers> M-926 (sorbitol 6EO modified acrylate, 2.5-functional) NK ester A-600 (polyethylene glycol diacrylate, EO repeats = 14) NK ester 14G (polyethylene glycol dimethacrylate, EO repeats = 14) <Non-water-soluble monofunctional monomers> DEAEMA (N,N-diethylaminoethyl methacrylate) <Non-water-soluble crosslinked monomer> N,N'-methylenebismethacrylamide N,N'-methylenebisacrylamide FOM-03006 (N-[tris(3-acrylamidopropoxymethyl)methyl]acrylamide) <Water-soluble photoinitiator> LAP (lithium phenyl-2,4,6-trimethylbenzoylphosphinate)

[0080] [Experimental Examples 1 and C1] At room temperature, each component was added to a container and mixed in the proportions shown in Table 1 to obtain a polymerizable composition. The polymerizable composition was poured into a transparent mold (made of polypropylene, corresponding to a contact lens with a diameter of 14.2 mm and a thickness of 0.08 mm) that formed a contact lens-shaped cavity. Next, UV light was irradiated onto the mold using an LED lamp at room temperature to perform photopolymerization. The contact lens-shaped polymer material (hereinafter referred to as the contact lens) was removed from the mold. The contact lens was subjected to an elution treatment (immersion in pH 7.5 phosphate buffer), and then hydrated by immersion in pH 7.5 phosphate buffer again. The hydrated contact lens was sealed in a package with a packaging solution, and then subjected to autoclaving at 121°C for 20 minutes. This obtained the finished contact lens.

[0081] Various evaluations were conducted on polymerizable compositions and finished contact lenses. The evaluation results are shown in Table 1. The evaluation methods are as follows. In each evaluation, for polymer materials other than contact lens shapes, polymer plates polymerized, eluted, and hydrated using molds with corresponding void shapes, similar to the experimental examples above, were used as measurement samples.

[0082] <Appearance> The appearance of the polymerizable composition and the finished contact lenses were observed visually.

[0083] <Moisture Content> The surface moisture of the finished contact lens was lightly wiped off after immersion in a pH 7.5 phosphate buffer solution at 20-23°C. The mass W1 at equilibrium moisture content and the mass W2 of the contact lens after drying in an oven at 105°C for 16-18 hours were measured, and the moisture content was calculated using the following formula: Moisture Content (%) = (W1 - W2) / W1 × 100

[0084] <Tensile Modulus (Young's Modulus)> A dumbbell-shaped sample with a stretched portion width of approximately 1.8 mm and a thickness of approximately 0.1 mm was punched out from a finished contact lens and used as a test sample. Tensile tests were performed in physiological saline solution at 20°C using a Shimadzu Autograph AGS-X precision universal testing machine manufactured by Shimadzu Corporation, and Young's modulus (MPa) was calculated as the tensile modulus from the stress-elongation curve. The tensile speed was set to 100 mm / min.

[0085] <Oxygen Permeability Coefficient (Dk Value)> A circular plate-shaped polymer plate (approximately 250 μm thick) with a diameter of 14.0 mm was used as the measurement sample. As a reference standard, a similar plate-shaped sample was prepared using the material of "Menicon Soft 72" (manufactured by Menicon Corporation), and its Dk value was set to 34. The measurement sample was set on the electrode, and using a Seikaken-type film oxygen permeability meter (manufactured by Rika Seiki Kogyo Co., Ltd.), the current value at equilibrium was set to zero by nitrogen bubbling in physiological saline at 35°C. Next, the current value at equilibrium was recorded by oxygen bubbling. This was also performed for the reference standard. The oxygen permeability coefficient of the lens was calculated according to the following formula. The unit of the oxygen permeability coefficient is (×10 －１１ (cm ２ / sec)・(mLO ２ The formula is (mL × mmHg) = Barrer. Dk value = R × (IS / IR) × (TS / TR) × (PR / PS) Here, the meaning of the symbols in the above formula is as follows: R: Dk value of the reference standard (34) IS: Current value of the sample to be measured (μA) IR: Current value of the reference standard (μA) TS: Average thickness of the sample to be measured (mm) TR: Average thickness of the reference standard (mm) PS: Atmospheric pressure when measuring the sample to be measured (mmHg) PR: Atmospheric pressure when measuring the reference standard (mmHg)

[0086] <Dynamic Friction Coefficient> The finished contact lenses were removed from a pH 7.5 phosphate buffer solution and immersed in physiological saline overnight. At room temperature (approximately 23°C), the test lenses were placed in a hemispherical jig made of plastic resin with the front curved surface facing upwards, and the lenses were fixed in place to prevent movement. The jig was filled with physiological saline to the extent that the surface of the contact lenses was covered, and a friction test was performed using an Anton Paar Nanotribometer NTR3. A 1.5 mm sapphire ball was used as the sliding material, and measurements were taken by linear sliding under conditions of a load of 2.5 mN and a sliding speed of 1.0 mm / s or 2.5 mm / s, and the kinetic friction coefficient was calculated.

[0087] <Contact Angle> After immersing the finished contact lenses in pH 7.5 phosphate buffer solution, the surface moisture was lightly wiped off, and physiological saline solution was dropped onto the front curved surface of each lens. The contact angle (°) of the water droplet was measured using a Drop Master 500 manufactured by Kyowa Interface Chemical Co., Ltd.

[0088] <Feel> Testers lightly drained the finished contact lenses and evaluated the feel when they moved their fingers while lightly pressing them against the lens surface. [Evaluation Criteria] ◎: No resistance, slides smoothly ○: Slight resistance felt, but slides △: Resistance felt, slides slightly

[0089] <Strength> The strength of the contact lenses was evaluated by the testers lightly draining the water from the finished product, pinching the left and right edges of the lens with their fingers and pulling them to the left and right, rubbing the lens surface with two fingers, and bending the lens with their fingers. [Evaluation Criteria] ◎: Does not tear in all of the following cases: pulling, rubbing, and bending ○: Does not tear in both of the following cases: pulling and rubbing, but tears in the following cases: bending △: Does not tear in the following cases: rubbing, but tears in both the following cases: pulling and bending ×: Tears in all of the following cases: pulling, rubbing, and bending

[0090]

[0091] As shown in Table 1, both the polymerizable composition containing sodium hyaluronate and the contact lens in Experimental Example 1, and the polymerizable composition without sodium hyaluronate and the contact lens in Experimental Example 1C, were transparent. The contact lens in Experimental Example 1 showed a lower coefficient of dynamic friction than the contact lens in Experimental Example 1C. Furthermore, the contact lens in Experimental Example 1 exhibited superior lubricity in terms of feel and showed improved strength.

[0092] [Experimental Examples 2-19] Polymerizable compositions were obtained in the same manner as in Experimental Example 1, except that each component was used in the proportions shown in Tables 2-19. Using the polymerizable compositions, finished contact lenses were obtained in the same manner as in Experimental Example 1. Various evaluations were performed on the polymerizable compositions and the finished contact lenses. The results are shown in Tables 2-19.

[0093]

[0094] As shown in Table 2, transparent polymerizable compositions and contact lenses were obtained at sodium hyaluronate concentrations ranging from 0.1% by mass to 1% by mass. As the concentration of sodium hyaluronate increased, the lubricity and elongation tended to increase (making it less likely to tear when pulled).

[0095]

[0096] As shown in Table 3, transparent polymerizable compositions and contact lenses were obtained at sodium hyaluronate concentrations of 0%, 0.5%, and 1% by mass. As the concentration of sodium hyaluronate increased, the lubricity and elongation tended to increase (making it less likely to tear when pulled).

[0097]

[0098] As shown in Table 4, in experimental examples using two types of crosslinking monomers in combination, transparent polymerizable compositions and contact lenses were obtained. There was a tendency for the strength to increase (the elongation when pulled decreased) as the content of the crosslinking monomers increased.

[0099]

[0100] As shown in Table 5, in Experimental Examples 5-1C and 5-2C, in which the content of water-soluble monofunctional monomers was increased and the content of solvent was decreased compared to Experimental Example 3-2, transparent polymerizable compositions were obtained, but precipitates were formed in the polymer material.

[0101]

[0102] As shown in Table 6, in experimental examples where two types of crosslinked monomers were used in combination and the water concentration was varied, in experimental examples 6-1C and 6-2C, where the water content in the total content A of the monomer component, hyaluronic acid component, and solvent was 20.5% by mass, undissolved residue was observed, and a transparent polymerizable composition could not be obtained.

[0103]

[0104] As shown in Table 7, transparent polymerizable compositions and contact lenses were obtained in experimental examples where the type or content ratio of crosslinking monomers was changed.

[0105]

[0106] As shown in Table 8, transparent polymerizable compositions and contact lenses were obtained at sodium hyaluronate concentrations ranging from 0.5% by mass to 1.25% by mass.

[0107]

[0108] As shown in Table 9, transparent polymerizable compositions and contact lenses were obtained in experimental examples where the type or content ratio of crosslinking monomers was changed.

[0109]

[0110] As shown in Table 10, transparent polymerizable compositions and contact lenses were obtained in experimental examples with different monomer component compositions. Experimental Examples 10-1, 10-3, and 10-4 contain a first water-soluble monofunctional monomer A (GMA) and a second water-soluble monofunctional monomer (NMMP), but do not contain the first water-soluble monofunctional monomer B. Experimental Example 10-2 contains a first water-soluble monofunctional monomer A (GMA) and a first water-soluble monofunctional monomer B (HEMA), but does not contain the second water-soluble monofunctional monomer.

[0111]

[0112] As shown in Table 11, transparent polymerizable compositions and contact lenses were obtained in experimental examples with different monomer component compositions.

[0113]

[0114] As shown in Table 12, transparent polymerizable compositions and contact lenses were obtained in experimental examples with different amounts of initiator used.

[0115]

[0116] As shown in Table 13, at sodium hyaluronate concentrations of 0.05% to 0.5% by mass, if the water content in the total content A was less than 21% by mass, undissolved residue was observed, and a transparent polymerizable composition could not be obtained.

[0117]

[0118] As shown in Table 14, when water was used at a sodium hyaluronate concentration of 0.1% to 0.5% by mass, with a total content A of 24.9% by mass or more, a transparent polymerizable composition and contact lenses were obtained.

[0119]

[0120] As shown in Table 15, transparent polymerizable compositions and contact lenses were obtained in experimental examples with different sodium hyaluronate concentrations and monomer compositions. Transparent polymerizable compositions and contact lenses were also obtained in experimental examples where DMAA or NVP was used instead of NMMP, or in combination with NMMP, as the second water-soluble monofunctional monomer.

[0121]

[0122] As shown in Table 16, transparent polymerizable compositions and contact lenses were obtained in experimental examples with different monomer compositions. Transparent polymerizable compositions and contact lenses were also obtained in experimental examples where HEAA was used instead of HEMA, or in combination with HEMA, as the first water-soluble monofunctional monomer B. In experimental example 16-1, the monomer component did not contain the second water-soluble monofunctional monomer.

[0123]

[0124] As shown in Table 17, transparent polymerizable compositions and contact lenses were obtained in experimental examples with different monomer compositions. Transparent polymerizable compositions and contact lenses were also obtained in experimental examples using the first water-soluble monofunctional monomer B (HEAA), which has a nitrogen atom, instead of the second water-soluble monofunctional monomer. In experimental examples 17-1 to 17-4, the monomer component does not contain the second water-soluble monofunctional monomer.

[0125]

[0126] As shown in Table 18, transparent polymerizable compositions and contact lenses were obtained in experimental examples with different monomer compositions. Transparent polymerizable compositions and contact lenses were also obtained in experimental examples using only the first water-soluble monofunctional monomer B (HEMA and HEAA) as the water-soluble monofunctional monomer.

[0127]

[0128] As shown in Table 19, transparent polymerizable compositions and contact lenses were obtained in experimental examples with different monomer compositions. Transparent polymerizable compositions and contact lenses were also obtained in experimental examples in which DEAEMA was used in combination as a non-water-soluble monofunctional monomer. By using DMAEMA or DEAEMA having an amine moiety, an effect of improving strength was obtained, and transparent contact lenses were obtained without using water-soluble crosslinked monomers.

[0129] The polymerizable compositions and polymer materials according to embodiments of the present invention can be suitably used in ophthalmic lenses such as contact lenses, intraocular lenses, artificial corneas, corneal onlays, and corneal inlays.

Claims

1. A polymer material comprising a polymer component containing constituent units derived from a monomer component and a polysaccharide component, wherein the monomer component includes a water-soluble monomer and the polysaccharide component does not have polymerizable functional groups.

2. The polymer material according to claim 1, wherein the polysaccharide component comprises at least one selected from hyaluronic acid or a salt thereof.

3. The polymer material according to claim 1, wherein the weight-average molecular weight of the polysaccharide component is 10,000 to 2,500,000.

4. The polymer material according to claim 1, wherein the water-soluble monomer comprises a water-soluble monofunctional monomer.

5. The polymer material according to claim 4, wherein the content of the water-soluble monofunctional monomer in the monomer component is 25% by mass to 100% by mass.

6. The polymer material according to claim 4, wherein the water-soluble monofunctional monomer comprises a first water-soluble monofunctional monomer having a hydroxyl group, and the first water-soluble monofunctional monomer comprises at least one selected from a first water-soluble monofunctional monomer A having two or more hydroxyl groups and a first water-soluble monofunctional monomer B having one hydroxyl group.

7. The polymer material according to claim 6, wherein the water-soluble monofunctional monomer further comprises a second water-soluble monofunctional monomer that does not have a hydroxyl group.

8. The polymer material according to claim 7, wherein the content of the second water-soluble monofunctional monomer in the monomer component is 1% by mass to 75% by mass.

9. The polymer material according to claim 6, wherein the first water-soluble monofunctional monomer comprises the first water-soluble monofunctional monomer A and the first water-soluble monofunctional monomer B.

10. The polymer material according to claim 9, wherein the content of the first water-soluble monofunctional monomer A in the monomer component is 1% by mass to 99% by mass, and the content of the first water-soluble monofunctional monomer B in the monomer component is 1% by mass to 99% by mass.

11. The polymer material according to claim 6, wherein the first water-soluble monofunctional monomer comprises glycerol monomethacrylate as the first water-soluble monofunctional monomer A.

12. The polymer material according to claim 6, wherein the first water-soluble monofunctional monomer comprises at least one selected from hydroxyethyl methacrylate and hydroxyethyl acrylamide as the first water-soluble monofunctional monomer B.

13. The polymer material according to claim 4, wherein the water-soluble monomer further comprises a water-soluble crosslinked monomer.

14. The polymer material according to claim 13, wherein the content of the water-soluble crosslinked monomer in the monomer component is 0.1% by mass to 75% by mass.

15. A polymer material according to claim 1, obtained by polymerizing a polymerizable composition comprising the monomer component, the polysaccharide component, and a solvent, wherein the solvent contains water, and the proportion of water in the total content A of the monomer component, the polysaccharide, and the solvent is 24% by mass or more.

16. The polymer material according to claim 15, wherein the content ratio of the polysaccharide component in the total content A is 1% by mass or less.

17. The polymer material according to claim 15, wherein the polymerizable composition further comprises a water-soluble polymerization initiator.

18. The polymer material according to claim 1, wherein the water content is 30% or more and 85% or less.

19. An ophthalmic lens comprising the polymer material described in claim 1.

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