Customized skin care regimes

Abstract

Provided herein are methods for providing customized skin regimen for a subject based on factors include one or more of an individual's demographics, phenotypic skin appearance, and concerns of the individual (e.g., as determined through a skin questionnaire). The skin regimen includes suggestions for one or more of topicals, supplements, and life style of the subject.

Description

Attorney Docket No.: VIB-030WOCUSTOMIZED SKIN CARE REGIMESCROSS-REFERENCE

[0001] This application claims the benefit of and priority to U.S. Provisional Patent Application No. 63 / 714,828, filed October 31, 2024, which is incorporated by reference in its entirety herein.BACKGROUND

[0002] Flawless skin is universally desired by people, as they are constantly on the quest to find the “best” skin products to achieve even-toned, clear, and radiant skin. This has led to an exponential rise of unverified advice or products to achieve good skin in the market. A person’s skin health is dependent on factors such as susceptibility to skin irritants, allergies, immune function, genetic makeup, oxidative stress, collagen degradation, elastin degradation, and a variety of other factors. Commercial products have been created and developed to address common skin concerns such as pigmentation, acne, wrinkling, skin sagging, skin aging, etc., that correlate to the numerous skin health factors. However, although commercially available skin care products have attempted to cater to different skin types, these products generally lack the ability to improve the skin on personal level.SUMMARY

[0003] Disclosed herein are customized skin regimens (e.g., formulations) that can help improve an individual’s skin health based on a particular individual’s skin profile. Such customized skin regimen can effectively provide personalized skin products, dietary, supplement, and lifestyle suggestions along with routine monitoring strategies in accordance an individual’s skin profile.

[0004] Disclosed herein are customized skin regimens that can help improve an individual’s skin health based on a customized skin profile. Such customized skin regimen can effectively provide customized skin products in accordance with a phenotypic assessment of the individual’s skin profile.

[0005] Disclosed herein, in certain embodiments, is a method for treating a skin condition of a subject, the method comprising administering a customized skin regimen to the skin of the subject, wherein the customized skin regimen was determined for the subject by: for one or more skin activity categories, each skin activity category comprising at least one compound being considered for inclusion in the customized skin regimen: obtaining or having obtained one or more images captured of the subject’s skin; determining a phenotype score for one or more skin activity categories for the subject using the one or more images; assigning a IPTS / 200163675.3 |Attorney Docket No.: VIB-030WO phenotype treatment category to each of the one or more skin activity categories for the subject based on the phenotype score; and for the phenotype treatment category, determining a fixed value for each of a plurality of elements of the skin activity category using the corresponding treatment category.

[0006] Disclosed herein, in certain embodiments, is a method for determining a customized skin regimen for a subject, the method comprising: for one or more skin activity categories, each skin activity category comprising at least one compound being considered for inclusion in the customized skin regimen: obtaining or having obtained one or more images captured of the subject’s skin; determining a phenotype score for one or more skin activity categories for the subject using the one or more images; and assigning a phenotype treatment category to each of the one or more skin activity categories for the subject based on the phenotype score and for the phenotype treatment category, determining a fixed value for each of a plurality of elements of the skin activity category using the corresponding treatment category.

[0007] In some embodiments, the one or more skin activity categories comprise an anti-aging and wrinkle reduction category, a lymphatic drainage category, a skin firming and elasticity category, a brightening and pigmentation category, a UV / oxidative damage / DNA / cell damage category, an anti-inflammatory and soothing category, and a hydration and skin barrier repair category.

[0008] In some embodiments, the phenotype treatment category is determined to be a moderate category or a severe category.

[0009] In some embodiments, determining the phenotype score for the skin activity category comprises determining a first value from the one or more images of the subject’s skin and determining a second value from a questionnaire including a set of questions related to the skin activity category. In some embodiments, determining the phenotype score for the skin activity category comprises determining a phenotype treatment category score for the skin activity category by getting a sum of the first value determined from the image and the second value determined from the questionnaire and determining the phenotype treatment category for each skin activity category based on the sum of the first value and the second value.

[0010] In some embodiments, the at least one compound for each skin activity category comprises one or more peptide, vitamin, mineral, acid, prebiotic or probiotic.

[0011] In some embodiments, the one or more peptide for the anti-aging and wrinkle reduction category comprise one or more of palmitoyl pentapeptide-4 (Matrixyl), acetyl dipeptide- 1 cetyl ester (Idealift), acetyl hexapeptide-8 (Argireline), acetyl hexapeptide- 30IPTS / 200163675.3 2Attorney Docket No.: VIB-030WG(InylineO-Peptide), acetyl hexapeptide- 51 amide (Juveleven), Argirelox (Pentapeptide 18+Argireline), SNAP 8-acetyl octapeptide- 3, Pal-Tripeptide 5, GHK Cu, Reproage™, Synake, palmitoyl pentapeptide 38 or Tripeptide-29.

[0012] In some embodiments, the one or more peptide for the lymphatic drainage category comprises eyeseryl-acetyl tetrapeptide-5 or Dipeptide-2.

[0013] In some embodiments, one or more peptide for the skin firming and elasticity category comprise one or more of palmitoyl hexapeptide- 12 (Biopeptide EL), palmitoyl oligopeptide (Bio-bustyl), myristoyl pentapeptide- 8 (SymPeptide 222), palmitoyl oligopeptide (Biopeptide CL), acetyl heptapeptide 4 (Fensebiome), triptide-10 citrulline (Decorinyl), hexapeptide- 10 (Serilesine), acetyl tetrapeptide- 11 (Syniorage), acetyl hexapeptide-38 (Adifyline), hexapeptide- 11 (Peptide Vinci 2), acetyl dipeptide- 13 diphenylglycine (Relistase), Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate), or acetyl tetrapeptide- 2 (Uplevity).

[0014] In some embodiments, the one or more peptides for the hydration and skin barrier repair category comprise one or more of Decapeptide-4, acetyl hexapeptide-37 (Diffuporine), Oligopeptide-24 (EGF-like peptide), FSS Ceramide 3, sodium pea, or APT-GPF.

[0015] In some embodiments, the one or more peptides for the anti-inflammatory and soothing category comprise one or more of acetyl hexapeptide-49 (Delisens), palmitoyl tetrapeptide-7, acetyl tetrapeptide- 15 (Skinasensyl), polyquaternium-51, allantoin, hesperdine methyl chaicone, acetyl tetrapeptide-40 (TELANGYN), acetyl dipeptide-3 aminohexanoate (Bodyfensine), Oligopeptide- 10, or Acetyl Tetrapeptide-2 (Syn-UP).

[0016] In some embodiments, the one or more peptides for the brightening and pigmentation category comprise one or more of Hexapeptide- 2, Nonapeptide- 1 (Melanostatine), Decapeptide 12, Oligopeptide-34, Oligopeptide-51 or Tetrapeptide-30.

[0017] In some embodiments, the one or more peptides for the UV / Oxidative Damage / DNA / Cell damage category comprise one or more of DAP tripeptide 33, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), ferulic acid, acetyl tetrapeptide-22 (Thermostressine), acetyl heptapeptide- 1, or tripeptide-9 citrulline (dGlyage).

[0018] In some embodiments, the at least one compound comprises one or more prebiotic or probiotic. In some embodiments, the one or more prebiotic and probiotic comprise one or more of Pepha active, beta glucan, Bacillus extract, sea kelp extract, or alpaflor sebum.IPTS / 200163675.3 3Attorney Docket No.: VIB-030WO

[0019] In some embodiments, the at least one compound further comprises one or more vitamins. In some embodiments, the one or more vitamins comprises one or more of D- Panthenol, magnesium ascorbyl phosphate, tocopherols, or niacinamide.

[0020] In some embodiments, the customized skin regimen further comprises one or more base compound.

[0021] In some embodiments, the method further comprises: obtaining or having obtained one or more demographics of the subject; and determining the customized skin regimen for the subject based on the demographics of the subject. In some embodiments, the demographics comprise one or more of an age or gender of the subject.

[0022] In some embodiments, the method further comprises: obtaining or having obtained an image of a face from the subject; grading severities of one or more phenotypic parameters for the face of the subject based on the image; and determining the customized skin regimen for the subject based on the severity of the one or more phenotypic parameters. In some embodiments, the phenotypic parameters comprise one or more of wrinkles, periorbitalaround eyes (puffy eyes), nasolabial folds (laugh lines), worry lines, uneven skin tone / pigmentation, or age spots (liver spots).

[0023] In some embodiments, the method further comprises: obtaining or having obtained one or more responses to a skin questionnaire from the subject; and determining the customized skin regimen for the subject based on the one or more responses from the subject. In some embodiments, the skin questionnaire comprises one or more questions related to skin goals, type of skin, sun exposure, or skin proneness to external factors.

[0024] Disclosed herein, in some embodiments, is a method for providing a customized skin regimen to a subject, the method comprising: administering the customized skin regimen to the subject, wherein the customized skin regimen is determined according to the method of any one of the embodiments discloses herein.

[0025] Disclosed herein, in some embodiments, is a customized skin regimen, wherein the customized skin regimen is determined according to the method of any one of the embodiments disclosed herein.

[0026] In some embodiments, based on the phenotype score, the phenotype treatment category for: (a) the anti-aging and wrinkle reduction category is moderate or severe; (b) the lymphatic drainage category is moderate or severe; (c) the skin firming and elasticity category is moderate or severe; (d) the brightening and pigmentation category is moderate or severe; (e) the UV / oxidative damage / DNA / cell damage category is moderate or severe; (f)IPTS / 200163675.3 4Attorney Docket No.: VIB-030WG the anti-inflammatory and soothing category is moderate or severe ; and / or (g) the hydration and skin barrier repair category is moderate or severe.

[0027] In some embodiments, the anti-aging and wrinkle reduction category is moderate. In some embodiments, the composition comprises one or more of palmitoyl pentapeptide-4 (Matrixyl), acetyl dipeptide- 1 cetyl ester (Idealift), acetyl hexapeptide-8 (Argireline), acetyl hexapeptide-30 (InylineO-Peptide), acetyl hexapeptide- 51 amide (Juveleven), Argirelox (Pentapeptide 18+ Argireline), SNAP 8-acetyl octapeptide- 3, Pal-Tripeptide 5, GHK Cu, Reproage™, Synake, and palmitoyl pentapeptide 38. In some embodiments, the composition comprises one or more of: (a) 0.5%- 1% palmitoyl pentapeptide-4 (Matrixyl), (b) 3% acetyl dipeptide- 1 cetyl ester (Idealift), (c) 3%-6% acetyl hexapeptide-8 (Argireline), (d) 3%-4% acetyl hexapeptide-30 (InylineO-Peptide), (e) 0.5%-1.4% acetyl hexapeptide- 51 amide (Juveleven), (f) 3%-6% Argirelox (Pentapeptide 18+ Argireline), (g) l%-2% SNAP 8-acetyl octapeptide-3, (h) l%-2% Pal-Tripeptide 5, (i) 0.1%-0.3% GHK Cu, (j) 0.1%- 1% Reproage™, (k) l%-2% Synake, (1) 2%-3% palmitoyl pentapeptide 38, and / or (m) 0.1%- 0.5% Tripeptide-29. In some embodiments, the anti-aging and wrinkle reduction category is severe. In some embodiments, the composition comprises one or more of palmitoyl pentapeptide-4 (Matrixyl), acetyl dipeptide- 1 cetyl ester (Idealift), acetyl hexapeptide-8 (Argireline), acetyl hexapeptide-30 (InylineO-Peptide), acetyl hexapeptide- 51 amide (Juveleven), Argirelox (Pentapeptide 18+ Argireline), SNAP 8-acetyl octapeptide-3, Pal- Tripeptide 5, GHK Cu, Reproage™, Synake, and palmitoyl pentapeptide 38. In some embodiments, the composition comprises one or more of: (a) l%-3% palmitoyl pentapeptide-4 (Matrixyl), (b) 4% acetyl dipeptide-1 cetyl ester (Idealift), (c) 6.1%- 10% acetyl hexapeptide-8 (Argireline), (d) 4. l%-5% acetyl hexapeptide-30 (InylineO-Peptide), (e) 1.5%- 2% acetyl hexapeptide-51 amide (Juveleven), (f) 6.1%- 10% Argirelox (Pentapeptide 18+Argireline), (g) 2%-4% SNAP 8-acetyl octapeptide-3, (h) 2. l%-3% Pal-Tripeptide 5, (i) 0.3%-0.5% GHK Cu, (j) 1.1%-2% Reproage™, (k) 2.1%-4% Synake, (1) 3.1%-4% palmitoyl pentapeptide 38, and / or (m) 0.6%- 1% Tripeptide-29.

[0028] In some embodiments, the lymphatic drainage category is moderate. In some embodiments, the composition comprises one or more of eyeseryl-acetyl tetrapeptide- 5, Caffeine, and / or Dipeptide-2. In some embodiments, wherein the composition comprises one or more of: (a) l%-5% eyeseryl-acetyl tetrapeptide-5, (b) 0.5%-2% Caffeine, and / or (c) 0.5% -2% Dipeptide-2.

[0029] In some embodiments, the lymphatic drainage category is severe. In some embodiments, the composition comprises one or more of eyeseryl-acetyl tetrapeptide-5, IPTS / 200163675.3 CAttorney Docket No.: VIB-030WOCaffeine, and / or Dipeptide-2. In some embodiments, the composition comprises one or more of: (a) 5.1%- 10% eyeseryl-acetyl tetrapeptide- 5, (b) 2. l%-3% Caffeine, and / or (c) 2%-5% Dipeptide-2.

[0030] In some embodiments, the hydration and skin barrier repair category is moderate. In some embodiments, the composition comprises one or more of Decapeptide-4, acetyl hexapeptide-37 (Diffuporine), Oligopeptide-24 (EGF-like peptide), FSS Ceramide 3, sodium pea, and / or APT-GPF. In some embodiments, the composition comprises one or more of: (a) l%-3% Decapeptide-4, (b) 0.5%- 1% acetyl hexapeptide-37 (Diffuporine), (c) 0.01%-0.05% Oligopeptide-24 (EGF-like peptide), (d) l%-3% FSS Ceramide 3, (e) l%-3% sodium pea, and / or (f) 0.1 %-0.4% APT-GPF.

[0031] In some embodiments, the hydration and skin barrier repair category is severe. In some embodiments, the composition comprises one or more of Decapeptide-4, acetyl hexapeptide-37 (Diffuporine), Oligopeptide-24 (EGF-like peptide), FSS Ceramide 3, sodium pea, and / or APT-GPF. In some embodiments, the composition comprises one or more of: (a) 3.1%-5% Decapeptide-4, (b) l.l%-2% acetyl hexapeptide-37 (Diffuporine), (c) 0.06%-l% Oligopeptide-24 (EGF-like peptide), (d) 3.1%5% FSS Ceramide 3, € 3.1%5% sodium pea, and / or (e) 0.4%-l% APT-GPF.

[0032] In some embodiments, the anti-inflammatory and soothing category is moderate. In some embodiments, the composition comprises one or more of acetyl hexapeptide-49 (Delisens), palmitoyl tetrapeptide-7, acetyl tetrapeptide- 15 (Skinasensyl), polyquaternium-51, allantoin, hesperdine methyl chaicone, acetyl tetrapeptide-40 (TELANGYN), acetyl dipeptide-3 aminohexanoate (Bodyfensine), Oligopeptide- 10, Acetyl Tetrapeptide-2 (Syn- UP), or Hydroxypropyl Tetrahydropyrantriol (Proxylane). In some embodiments, the composition comprises one or more of: (a) 2%-3% acetyl hexapeptide-49 (Delisens), (b) 1%- 2% palmitoyl tetrapeptide-7, (c) 0.3%-0.5% acetyl tetrapeptide- 15 (Skinasensyl), (d) 0.5%- 1.5% polyquaternium-51, (e) 0. l%-0.5% allantoin, (f) 0.1%-0.3% hesperdine methyl chaicone, (g) 0.1%-1% acetyl tetrapeptide-40 (TELANGYN), (h) 2%-3.5% acetyl dipeptide- 3 aminohexanoate (Bodyfensine), (i) Oligopeptide- 10, (j) 0.5%- 1% % Acetyl Tetrapeptide-2 (Syn-UP), and / or (k) 0.5%-l% Hydroxypropyl Tetrahydropyrantriol (Proxylane).

[0033] In some embodiments, the anti-inflammatory and soothing category is severe. In some embodiments, the composition comprises one or more of acetyl hexapeptide-49 (Delisens), palmitoyl tetrapeptide-7, acetyl tetrapeptide- 15 (Skinasensyl), polyquaternium-51, allantoin, hesperdine methyl chaicone, acetyl tetrapeptide-40 (TELANGYN), acetyl dipeptide-3 aminohexanoate (Bodyfensine), Oligopeptide- 10, Acetyl Tetrapeptide-2 (Syn-UP), or IPTS / 200163675.3 f.Attorney Docket No.: VIB-030WOHydroxypropyl Tetrahydropyrantriol (Proxylane). In some embodiments, the composition comprises one or more of: (a) 3. l%-5% acetyl hexapeptide-49 (Delisens), (b) 2. l%-3% palmitoyl tetrapeptide-7, (c) 0.6%-2% acetyl tetrapeptide- 15 (Skinasensyl), (d) 1.6%-5% polyquaternium-51, (e) 0.6%-2% allantoin, (f) 0.4%-0.6% hesperdine methyl chaicone, (g) 1.1%-2% acetyl tetrapeptide-40 (TELANGYN), (h) 3.6%-5% acetyl dipeptide-3 aminohexanoate (Bodyfensine), (i) Oligopeptide- 10, j) 1.1%-3% Acetyl Tetrapeptide-2 (Syn-UP), and / or 1.1%-2% Hydroxypropyl Tetrahydropyrantriol (Proxylane).

[0034] In some embodiments, the brightening and pigmentation category is moderate. In some embodiments, the composition comprises one or more of Hexapeptide-2, Nonapeptide- 1 (Melanostatine), Decapeptide 12, Oligopeptide-34, or Oligopeptide-51. In some embodiments, the composition comprises one or more of: (a) 0. l%-0.5% of Hexapeptide-2, (b) 0. l%-5% Nonapeptide-1 (Melanostatine), (c) 2%-6% Decapeptide 12, (d) Oligopeptide- 34, and / or (e) Oligopeptide-51, and / or (f) 0.5%-2% Tetrapeptide-30.

[0035] In some embodiments, the brightening and pigmentation category is severe. In some embodiments, the composition comprises one or more of Hexapeptide-2, Nonapeptide-1 (Melanostatine), Decapeptide 12, Oligopeptide-34, or Oligopeptide-51. In some embodiments, the composition comprises one or more of: (a) 0.6%- 1 % of Hexapeptide-2, (b) 5. l%-10% Nonapeptide-1 (Melanostatine), (c) 6. l%-10% Decapeptide 12, (d) Oligopeptide- 34, (e) Oligopeptide-51, and / or (f) 2%-5% Tetrapeptide-30.

[0036] In some embodiments, the UV / Oxidative Damage / DNA / Cell damage category is moderate. In some embodiments, the composition comprises one or more of DAP tripeptide 33, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), ferulic acid, acetyl tetrapeptide-22 (Thermostressine), acetyl heptapeptide- 1, or tripeptide-9 citrulline (dGlyage). In some embodiments, the composition comprises one or more of: (a) 0.5%- 1 % DAP tripeptide 33, (b) 0. l%-0.5% Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), (c) 0. l%-0.5% ferulic acid, (d) 2%-3% acetyl tetrapeptide-22 (Thermostressine), (e) 0. l%-5% acetyl heptapeptide- 1, and / or (f) 2%-3% tripeptide-9 citrulline (dGlyage).

[0037] In some embodiments, the UV / Oxidative Damage / DNA / Cell damage category is severe. In some embodiments, the composition comprises one or more of DAP tripeptide 33, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), ferulic acid, acetyl tetrapeptide-22 (Thermostressine), acetyl heptapeptide- 1, or tripeptide-9 citrulline (dGlyage). In some embodiments, the composition comprises one or more of: (a) 1.1%-5% DAP tripeptide 33, (b) 0.6%- 1% Pepha-tight (Nannochloropsis Oculata (Algae) Extract andIPTS / 200163675.3 7Attorney Docket No.: VIB-030WOPullulan), (c) 0.6%-l% ferulic acid, (d) 3. l%-5% acetyl tetrapeptide-22 (Thermostressine), (e) 5.1%- 10% acetyl heptapeptide- 1, and / or (f) 3. l%-5% tripeptide-9 citrulline (dGlyage).

[0038] In some embodiments, the skin firming and elasticity category is moderate. In some embodiments, the composition comprises one or more of palmitoyl hexapeptide- 12 (Biopeptide EL), palmitoyl oligopeptide (Bio-bustyl), myristoyl pentapeptide- 8 (SymPeptide 222), palmitoyl oligopeptide (Biopeptide CL), acetyl heptapeptide 4 (Fensebiome), triptide- 10 citrulline (Decorinyl), hexapeptide- 10 (Serilesine), acetyl tetrapeptide- 11 (Syniorage), acetyl hexapeptide-38 (Adifyline), hexapeptide- 11 (Peptide Vinci 2), acetyl dipeptide- 13 diphenylglycine (Relistase), Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate), or acetyl tetrapeptide- 2 (Uplevity).

[0039] In some embodiments, the composition comprises one or more of: (a) 3%-6% palmitoyl hexapeptide- 12 (Biopeptide EL), (b) 0.2%-0.5% palmitoyl oligopeptide (Bio- bustyl), (c) 0.01%-0.05% myristoyl pentapeptide- 8 (SymPeptide 222), (d) 0. l%-0.5% acetyl heptapeptide 4 (Fensebiome), (e) l%-3% triptide-10 citrulline (Decorinyl), (f) l%-5% hexapeptide- 10 (Serilesine), (g) 1350 ppm - 1500 ppm acetyl tetrapeptide- 11 (Syniorage), (h) 0.1%-l% acetyl hexapeptide-38 (Adifyline), (i) 0.5%-l% hexapeptide- 11 (Peptide Vinci 2), (j) l%-2% acetyl dipeptide- 13 diphenylglycine (Relistase), (k) 0.1%-0.5% Syn-TacksSyn- Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate), and / or (1) 0.1%- 1% acetyl tetrapeptide- 2 (Uplevity).

[0040] In some embodiments, the skin firming and elasticity category is severe. In some embodiments, the composition comprises one or more of palmitoyl hexapeptide- 12 (Biopeptide EL), palmitoyl oligopeptide (Bio-bustyl), myristoyl pentapeptide- 8 (SymPeptide 222), palmitoyl oligopeptide (Biopeptide CL), acetyl heptapeptide 4 (Fensebiome), triptide- 10 citrulline (Decorinyl), hexapeptide- 10 (Serilesine), acetyl tetrapeptide- 11 (Syniorage), acetyl hexapeptide-38 (Adifyline), hexapeptide- 11 (Peptide Vinci 2), acetyl dipeptide- 13 diphenylglycine (Relistase), Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate), or acetyl tetrapeptide- 2 (Uplevity). In some embodiments, the composition comprises one or more of: (a) 6.1%- 10% palmitoyl hexapeptide- 12 (Biopeptide EL), (b) 0.6%- 1% palmitoyl oligopeptide (Bio- bustyl), (c) 0.06%-0.1% myristoyl pentapeptide- 8 (SymPeptide 222), (d) 0.6%- 1% acetyl heptapeptide 4 (Fensebiome), (e) 3. l%-5% triptide-10 citrulline (Decorinyl), (f) 5.1%- 10% hexapeptide- 10 (Serilesine), acetyl tetrapeptide- 11 (Syniorage), (g) l.l%-2% acetyl hexapeptide-38 (Adifyline), (h) 1.1%-1.5% hexapeptide- 11 (Peptide Vinci 2), (i) 2.1%-4% IPTS / 200163675.3 OAttorney Docket No.: VIB-030WG acetyl dipeptide-13 diphenylglycine (Relistase), j) 0.6%-l% Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate), and / or (k) 1.1%-2% acetyl tetrapeptide- 2 (Uplevity).

[0041] In some embodiments, the skin firming and elasticity category is moderate. In some embodiments, the composition comprises one or more of Pepha active, beta glucan, Bacillus extract, sea kelp extract, or alpaflor sebum. In some embodiments, the composition comprises one or more of: (a) l%-3% Pepha active, (b) l%-3% beta glucan, (c) 0.5%- 1 % Bacillus extract, (d) 0.5%- 1% sea kelp extract, and / or (e) 0.5%- 1% alpaflor sebum.

[0042] In some embodiments, the skin firming and elasticity category is severe. In some embodiments, the composition comprises one or more of Pepha active, beta glucan, Bacillus extract, sea kelp extract, or alpaflor sebum. In some embodiments, the composition comprises one or more of: (a) 3. l%-5% Pepha active, (b) 3. l%-5% beta glucan, (c) 1.1%-2% Bacillus extract, (d) 1.1%-2% sea kelp extract, and / or (e) l%-2% alpaflor sebum.

[0043] In some embodiments, the skin firming and elasticity category is moderate. In some embodiments, the composition comprises one or more of D-Panthenol, magnesium ascorbyl phosphate, tocopherols, or niacinamide. In some embodiments, the composition comprises one or more of: (a) 0.5%- 1% D-Panthenol, (b) 0.2%-l% magnesium ascorbyl phosphate, (c) 0.1% tocopherols, and / or (d) 0.1%-2% niacinamide.

[0044] In some embodiments, the skin firming and elasticity category is severe. In some embodiments, the composition comprises one or more of D-Panthenol, magnesium ascorbyl phosphate, tocopherols, or niacinamide. In some embodiments, the composition comprises one or more of: (a) 1.1%-2% D-Panthenol, (b) 1.1%-2% magnesium ascorbyl phosphate, (c) 0.2% tocopherols, and / or (d) 2. l%-5% niacinamide.

[0045] In some embodiments, the composition comprises a peptide, wherein the peptide is one or more of Hexapeptide- 11, GHK-Cu, Palmitoyl Pentapeptide-4 (Pal-KTTKS), Palmitoyl Tetrapeptide-7 (Pal-GQPR), Dipeptide-2, Palmitoyl Pentapeptide-4, decapeptide- 12, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxy threonine, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Acetyl Tetrapeptide-5, Heptapeptide-4, Acetyl Hexapeptide-51 Amide, Acetyl Hexapep tide-30, Acetyl Hexapeptide- 8 (Argireline), acetyl hexapeptide-3 (Argireline), Acetylarginyltryptophyl Diphenylglycine, Acetyl Hexapeptide-37, Hexapeptide- 10, Acetyl Octapeptide-3, Tetrapeptide- 1, Tetrapeptide- 2, Acetyl Tetrapeptide-2, Acetyl Hexapeptide-38, Acetyl Dipeptide-3 Aminohexanoate, Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide-49, Pentapeptide 18, Tripeptide 29, IPTS / 200163675.3 QAttorney Docket No.: VIB-030WONonapeptide- 1, Tripeptide 5, Palmitoyl Tripeptide-5, Diaminopropionoyl (DAP) Tripeptide- 33, beta glucan, and / or bacillus extract.

[0046] In some embodiments, the composition comprises a retinoid, wherein the retinoid is one or more of retinol, retinal, tretinoin (retinoic acid), isotretinoin, alitretinoin, adapalene, bexarotene, tazarotene, and / or Trifarotene.

[0047] In some embodiments, the composition comprises an omega-3 fatty acid, wherein the omega-3 fatty acid is one or more of Alpha-linolenic acid (ALA), Eicosapentaenoic acid (EPA), and / or Docosahexaenoic acid (DHA).

[0048] In some embodiments, the composition comprises an Alpha hydroxy acid, wherein the Alpha hydroxy acid is one or more of glycolic acid, lactic acid, mandelic acid, and / or citric acid.

[0049] In some embodiments, a phenotypic parameter is wrinkles, Periorbital-around eyes (puffy eyes), Nasolabial folds (Laugh lines), worry lines, Uneven Skin tone / Pigmentation, and / or Age spots (Liver spots) and the composition comprises one or more of Tretinoin, Zeaxanthin, Retinol, Retinoids, Vitamin C, Hyaluronic acid, Caffeine, Phytonadione, Vitamin E, Astaxanthin, Hyaluronic acid, Peptides, Niacinamide, Azelaic acid, Soybean extract, Kojic acid, Aloesin, and / or Turmeric. In some embodiments, the customized skin regimen further comprises one or more of Zeaxanthin, Collagen, Vitamin C, Resveratrol, Vitamin E, Vitamin C, Hyaluronic acid, Glutathione, Niacinamide, and / or Coenzyme Q10.

[0050] In some embodiments, a skin questionnaire question is: (a) UV and the composition comprises one or more of Zinc oxide, titanium oxide, Polypodium leucotomos, Vitamin E, Vitamin C, and / or Niacinamide; (b) Anti-wrinkling and the composition comprises one or more of Tretinoin, Zeaxanthin, Retinol, Vitamin C, Hyaluronic acid, Collagen, Resveratrol, and / or Vitamin E; (c) Anti-pigmentation and the composition comprises one or more of Niacinamide, Azelaic acid, Vitamin C, Soybean extract, Retinoids, Kojic acid, Vitamin E, Aloesin, Turmeric, and / or Glutathione (d) Moisturization and the composition comprises one or more of Hyaluronic acid, Glycerin, Shea butter, Jojoba oil, Hyaluronan, Ceramides, and Collagen; (e) Radiant complexion and the composition comprises one or more of Vitamin C and / or Niacinamide, (f) Dry skin and the composition comprises Glycerin; (g) Combinational skin and the composition comprises Hyaluronic acid; (h) Acne-prone skin and the composition comprises Benzoyl peroxide; (i) Sun exposure and the composition comprises Zinc oxide and / or Titanium dioxide; (j) Sensitive skin - stinging or burning and the composition comprises Niacinamide; (k) Sun and Humidity and the composition comprises one or more of Vitamin E, Zinc oxide, Astaxanthin, and / or Omega-3 fatty acids; (1) Wind andIPTS / 200163675.3 1 nAttorney Docket No.: VIB-030WG cold and the composition comprises one or more of Petroleum jelly, Omega-3 fatty acids, and / or Probiotics.

[0051] In some embodiments, the customized skin regimen further comprises an excipient or carrier. In some embodiments, the excipient or carrier is one or more of water, Caprylyl Glycol, butylene glycol, ultra low molecular weight (ulmw) hyaluronic acid, middle molecular weight (MMW) hyaluronic acid, and / or dimethyl isosorbide

[0052] Discloses herein, in certain embodiments, is a customized skin regimen, wherein the customized skin regimen comprises one or more supplement or topical medication, or a supplement and a topical medication.

[0053] In some embodiments, the one or more topical medication and / or supplement comprise one or more of B-vitamins, Vitamin Bl, Vitamin B2, Vitamin B3, Vitamin B6, Vitamin B 12, vitamin C, vitamin D, vitamin E, vitamin F, peptides, retinoids, copper peptides, copper, zinc, collagen or collagen peptides, omega-3 fatty acids, hyaluronic acids, niacinamide, zinc, proline, glycine, vitamin E, alpha hydroxy acids, ginseng, green tea or green tea extract, capsaicin, zinc, probiotics, resveratrol, glycine, proline, green tea or green tea extract, silicon, niacinamide, silicon, vitamin A, aloe vera, Hydroquinone, Azelaic acid, Kojic acid, Cysteamine, Lignin peroxidase, Ellagic acid, L-Cystine, L-Glutathione, Polypodium leucotomos, Melatonin, Arbutin, Coenzyme Q10, Vitamin F, Kumazasa extract, Magnesium ascorbyl phosphate, Magnesium oil, ceramides, hyaluronan, procyanidin, probiotics, Galactooligosaccharides, Alpha-linolenic acid, Gamma-linolenic acid, Methylsulfonylmethane, Curcumin, Red ginseng, Aloe vera extract, Dexpanthenol, Polyphenols, Beta carotene, Flavanols, zinc, Lutein, Lycopene, Silymarin, Baicalin, Epigallocatechin gallate, Nicotinamide riboside, Nicotinamide mononucleotide, Zeaxanthin, Caffeine, Phytonadione, Astaxanthin, Soybean extract, Aloesin, Turmeric, Glycerin, Shea butter, Jojoba oil, Benzoyl peroxide, Conjugated Linoleic Acid, Berberine Extract, Quercetin, Calcium D-glucarate, Zinc oxide and / or Titanium dioxide.

[0054] In some embodiments, the peptide is one or more of Hexapeptide- 11, GHK-Cu, Palmitoyl Pentapeptide-4 (Pal-KTTKS), Palmitoyl Tetrapeptide-7 (Pal-GQPR), Dipeptide-2, Palmitoyl Pentapeptide-4, decapeptide- 12, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Acetyl Tetrapeptide-5, Heptapeptide-4, Acetyl Hexapeptide- 51 Amide, Acetyl Hexapeptide-30, Acetyl Hexapeptide-8 (Argireline), acetyl hexapeptide-3 (Argireline), Acetylarginyltryptophyl Diphenylglycine, Acetyl Hexapeptide-37, Hexapeptide- IPTS / 200163675.3 | |Attorney Docket No.: VIB-030WO10, Acetyl Octapeptide- 3, Tetrapeptide- 1, Tetrapeptide- 2, Acetyl Tetrapeptide-2, Acetyl Hexapep tide-38, Acetyl Dipeptide-3 Aminohexanoate, Tripeptide- 10 Citrulline (Decorinyl), Acetyl Hexapeptide-49, Pentapeptide 18, Tripeptide 29, Nonapeptide- 1, Tripeptide 5, Palmitoyl Tripeptide-5, Diaminopropionoyl (DAP) Tripep tide-33, beta glucan, and / or bacillus extract.

[0055] In some embodiments, the retinoid is one or more of retinol, retinal, tretinoin (retinoic acid), isotretinoin, alitretinoin, adapalene, bexarotene, tazarotene, and / or Trifarotene.

[0056] In some embodiments, the omega-3 fatty acid is one or more of Alpha-linolenic acid (ALA), Eicosapentaenoic acid (EPA), and / or Docosahexaenoic acid (DHA).

[0057] In some embodiments, the Alpha hydroxy acid is one or more of glycolic acid, lactic acid, mandelic acid, and / or citric acid.

[0058] In some embodiments, the customized skin regimen further comprises an excipient or carrier. In some embodiments, the excipient or carrier is one or more of water, Caprylyl Glycol, butylene glycol, ultra low molecular weight (ulmw) hyaluronic acid, middle molecular weight (MMW) hyaluronic acid, and / or dimethyl isosorbide.

[0059] In some embodiments, the customized skin regimen provided herein comprises a composition comprising any of the ingredients provided in any one of Tables 9-32, and / or comprises the composition provided in any one of Tables 9-32.

[0060] In some embodiments, the customized skin regimen provided herein comprises a composition comprising: (a) Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Acetyl Hexapeptide- 51 Amide (Juveleven™ Peptide Solution), Glycerin, Tripeptide-33 (DAP-Tripeptide-33), Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol, Ferulic Acid, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Panthenol, Copper Tripeptide- 1 (GHK-Cu), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Parfum (Sunkiss), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (MMW Hyaluronic Acid), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3); (b) Water (aqua), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Decapeptide- 12, Nonapeptide- 1, Tripeptide-33 (DAP-Tripeptide-33), Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide- 10 Citrulline (Decorinyl), IPTS / 200163675.3Attorney Docket No.: VIB-030WOHexapeptide- 11, Acetyl Octapeptide-3 (SNAP-8), PEG-16 Macadamia Glycerides, Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Sorbitol (Sorbitol 70), Acetyl Hexapeptide- 51 Amide (Juveleven™ Peptide Solution), Glycerin, Copper Tripeptide-1 (GHK-Cu), Acetyl Tetrapeptide- 15, Butylene Glycol, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Dimethyl Isosorbide, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Allantoin, Sodium Hyaluronate (MMW Hyaluronic Acid), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3 / NP); (c) Water (aqua), Acetyl Hexapeptide-8 (Argireline), Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Acetyl Octapeptide-3 (SNAP-8), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Hexapeptide- 11, Decapeptide- 12, Hexapeptide-49 (Delisens Solution), Decapeptide-4 (Reproage), Glycerin, Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG-16 Macadamia Glycerides, Tetrapeptide- 2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Syn- TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol, Palmitoyl Hexapeptide- 38 (Adifyline), Butylene Glycol, Dimethyl Isosorbide, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide-1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3); (d) Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Sorbitol, Nonapeptide- IPTS / 200163675.3 1Attorney Docket No.: VIB-030WG1, Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide- 30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Glycerin, Acetyl Hexapeptide-8 (Argireline), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide-2 (Uplevity), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low Molecular Weight), Ahnfeltiopsis concinna Extract (APT- GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Pentapeptide-3, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Sodium Phytate, Myristoyl Pentapeptide- 8; (e) Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide-10 Citrulline (Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide-2 (Uplevity), Parfum (Fragrance), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low Molecular Weight), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Sodium Phytate, Myristoyl Pentapeptide- 8; (f) Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide-10 Citrulline (Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn- Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, IPTS / 200163675.3Attorney Docket No.: VIB-030WOPepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide-2 (Uplevity), Parfum (Fragrance), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low Molecular Weight), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Sodium Phytate, Myristoyl Pentapeptide- 8; (g) Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide- 10 Citrulline (Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn- Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Pentapeptide-4, Dipeptide-2, Magnesium Ascorbyl Phosphate, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide-2 (Uplevity), Parfum (Fragrance), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex), Sodium Phytate; (h) Water (aqua), Tripeptide- 10 Citrulline (Decorinyl), Acetyl Tetrapeptide-5 (Eyeseryl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Magnesium Ascorbyl Phosphate, Acetyl Hexapeptide- 30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide- 7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide-2 (Uplevity), Parfum (Fragrance), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Clearthix S (Algin and Cellulose Gum), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic IPTS / 200163675.3 1 CAttorney Docket No.: VIB-030WOAcid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex), Sodium Phytate, Myristoyl Pentapeptide- 8; (i) Water (aqua), Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide-8 (Argireline), Acetyl Octapeptide- 3 (SNAP-8), Glycerin, Hexapeptide- 11, Decapeptide- 12, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapep tide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), PEG- 16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Palmitoyl Pentapep tide-38, Butylene Glycol, Dimethyl Isosorbide, Acetyl Hexapeptide- 38 (Adifyline), Tripeptide-33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer- 6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Eeaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate, Ceramide NP (Ceramide 3 / NP); (j) Water (aqua), Inyline (Tripeptide- 1 and Palmitoyl Tripeptide- 1 and Palmitoyl Tetrapeptide-7 and Acetyl Dipeptide- 1 Cetyl Ester, Nonapeptide- 1, Acetyl Hexapeptide-30), Hexapeptide-49 (Delisens), Tripeptide-10 Citrulline (Decorinyl), Acetyl Octapeptide-3 (SNAP-8), Hexapeptide- 11, Glycerin, Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, PEG-16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Sorbitol (Sorbitol 70), Butylene Glycol, Dimethyl Isosorbide, Magnesium Ascorbyl Phosphate, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta- Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Clearthix S (Algin and Cellulose Gum), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate,IPTS / 200163675.3 1 f.Attorney Docket No.: VIB-030WOGlyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Caffeine, Ceramide NP (Ceramide 3 / NP), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate; (k) Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Acetyl Hexapeptide- 51 Amide (Juveleven™ Peptide Solution), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Tripeptide-33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin Methyl Chaicone, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Ferulic Acid, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP); (1) Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Tripeptide- 33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin Methyl Chaicone, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Ferulic Acid, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP); (m) Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract andIPTS / 200163675.3 1 7Attorney Docket No.: VIB-030WOPentylene Glycol and Citric Acid), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Tripeptide- 33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Ferulic Acid, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP); (n) Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapep tide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Arginine / Lysine Polypeptide, Tripeptide- 33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP), Ferulic Acid; (o) Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapep tide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Glycerin, Acetyl Hexapeptide-38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Oligopeptide- 10, Tripeptide-33 (DAP- Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 IPTS / 200163675.3 1 OAttorney Docket No.: VIB-030WGOleate, and Sodium Surfactin), Parfum (Fragrance), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP), Ferulic Acid; (p) Water (aqua), Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide-8 (Argeriline), Acetyl Octapeptide- 3 (SNAP-8), Glycerin, Hexapeptide- 11, Decapeptide- 12, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), PEG- 16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Palmitoyl Pentapep tide-38, Butylene Glycol, Dimethyl Isosorbide, Hydroxypropyl Tetrahydropyrantriol (Proxylane), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Acetyl Hexapep tide-38 (Adifyline), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate, Ceramide NP (Ceramide 3 / NP); (q) Water (aqua), Acetyl Hexapeptide-8 (Argireline), Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Glycerin, Acetyl Octapeptide-3 (SNAP-8), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Hexapeptide- 11, Decapeptide- 12, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Hydroxypropyl Tetrahydropyrantriol (Proxylane), Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Palmitoyl Pentapep tide-38, Acetyl Hexapeptide- 38 (Adifyline), Butylene Glycol, Dimethyl Isosorbide, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, IPTS / 200163675.3 1 QAttorney Docket No.: VIB-030WOBacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3 / NP); (r) Water (aqua), Acetyl Tetrapeptide- 5 (Eyeseryl), Sorbitol (Sorbitol 70), Nonapeptide- 1, Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide- 30 (Inyline Solution), Glycerin, Acetyl Hexapeptide-8 (Argireline), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide-2 (Uplevity), Hexapeptide- 10 (Sirulisene), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Oligopeptide- 10, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Myristoyl Pentapeptide- 8; (s) Water (aqua), Palmitoyl Tripeptide- 1 (Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Acetyl Tetrapeptide- 5 (Eyeseryl), Acetyl Hexapeptide- 30 (Inyline), Nonapeptide- 1, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Acetyl Octapeptide-3 (SNAP-8), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Pentapeptide-4, Dipeptide-2, Magnesium Ascorbyl Phosphate, Decapeptide-4 (Reproage), Tetrapeptide-2 (Uplevity), Tetrapep tide-30, Macrocystis Pyrifera (Kelp) Extract, Panthenol (D-Panthenol), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Parfum (Fragrance), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, IPTS / 200163675.3 OhAttorney Docket No.: VIB-030WGHesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Phytate, Ceramide NP (Ceramide 3 / NP); (t) Water (aqua), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Tripeptide-10 Citrulline (Decorinyl), Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Acetyl Tetrapeptide-5 (Eyeseryl), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide- 2 (Uplevity), Parfum (Fragrance), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Hexapeptide- 11, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Phytate, Myristoyl Pentapeptide- 8; (u) Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Glycerin, Nonapeptide- 1, Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Hexapeptide-49, Tetrapeptide-30, Tripeptide-10 Citrulline (Decorinyl), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Palmitoyl Tetrapeptide-7, Dipeptide-2, Magnesium Ascorbyl Phosphate, Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Tripeptide-33 (DAP-Tripeptide-33), Macrocystis Pyrifera (Kelp) Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Acetyl Tetrapeptide- 15, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Decapeptide-4 (Reproage peptide), Tetrapeptide-2 (Uplevity), Palmitoyl Pentapeptide-4, Parfum (Fragrance), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Ferulic Acid, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex), Allantoin, Clearthix S (Algin and Cellulose Gum), Sodium Phytate; (v) Water (aqua), Acetyl Hexapeptide-8 (Argeriline), Acetyl Hexapeptide-30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Glycerin, Acetyl Octapeptide-3 (SNAP-8), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Palmitoyl Tripeptide-5, Decapeptide- IPTS / 200163675.3 21Attorney Docket No.: VIB-030WO12, Palmitoyl Tripeptide-38, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Nonapeptide- 1, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG-16 Macadamia Glycerides, Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide-29, Hexapeptide- 11, Tripeptide-33 (DAP- Tripeptide-33), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Tetrapeptide- 2 (Uplevity), Acetyl Hexapeptide-38 (Adifyline), Butylene Glycol, Dimethyl Isosorbide, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Copper Tripeptide- 1 (GHK-Cu), Syn- TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3 / NP); (w) Water (aqua), Decorinyl (Tripeptide- 1 and Palmitoyl Tripeptide- 1 and Palmitoyl Tetrapeptide-7 and Acetyl Dipeptide- 1 Cetyl Ester, Tripeptide- 10 Citrulline), Hexapeptide-49 (Delisens Solution), Acetyl Hexapeptide- 30 (Inyline), Hexapeptide-11, Acetyl Octapeptide-3 (SNAP-8), Nonapeptide- 1, Palmitoyl Tripeptide-5, Dipeptide-2, Acetyl Tetrapeptide- 15, Tetrapeptide-2 (Uplevity), PEG-16 Macadamia Glycerides, Hydroxypropyl Tetrahydropyrantriol (Proxylane), Parfum (Fragrance), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide-29, Palmitoyl Pentapeptide-4, Tripeptide-33 (DAP-Tripeptide-33), Sorbitol (Sorbitol 70), Glycerin, Decapeptide-4 (Reproage), Butylene Glycol, Dimethyl Isosorbide, Magnesium Ascorbyl Phosphate, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta- Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Copper Tripeptide- 1 (GHK-Cu), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Caffeine, Ceramide NP (Ceramide 3 / NP), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate; or (x) Water (aqua), Inyline (Tripeptide- 1 and Palmitoyl Tripeptide- 1 and Palmitoyl Tetrapeptide-7 and Acetyl Dipeptide- 1 Cetyl Ester, Nonapeptide- 1, Acetyl Hexapeptide-30), Hexapeptide-49 (Delisens), Tripeptide- 10 Citrulline (Decorinyl), Acetyl Octapeptide-3 (SNAP-8), Hexapeptide-11, Glycerin, Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, IPTS / 200163675.3 22Attorney Docket No.: VIB-030WGPalmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, PEG- 16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Sorbitol (Sorbitol 70), Oligopeptide- 10, Butylene Glycol, Dimethyl Isosorbide, Magnesium Ascorbyl Phosphate, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Clearthix S (Algin and Cellulose Gum), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Caffeine, Ceramide NP (Ceramide 3 / NP), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate.

[0061] In various embodiments, methods disclosed herein further comprise additionally administering the customized skin regimen one or more times to the subject. In various embodiments, the customized skin regimen is additionally administered one or more times to the subject without re-determining the customized skin regimen. Additionally disclosed herein is a customized skin regimen determined according to any of the methods disclosed herein.BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

[0062] These and other features, aspects, and advantages of the present disclosure will become better understood with regard to the following description, and accompanying drawings, where:

[0063] FIG. 1 depicts a system overview for determining a customized skin regimen for an individual, in accordance with an embodiment.

[0064] FIG. 2 provides a diagram showing the information used to determine a customized skin regimen, in accordance with an embodiment.

[0065] FIG. 3 illustrates an example computing device for implementing system and methods described in FIGs. 1-2.DETAILED DESCRIPTIONDefinitions

[0066] Terms used in the claims and specification are defined as set forth below unless otherwise specified.IPTS / 200163675.3 23Attorney Docket No.: VIB-030WO

[0067] Abbreviations used in this application include the following:

[0068] The term “topical” is a medication pertaining to the skin, such as a topical anti- infective agent applied to a certain area of skin and affecting only the area to which it is applied. The topical or topical medication includes a large range of classes including creams, foams, gels, lotions, and ointments to treat ailments of the skin.

[0069] The term “supplement” is a product taken to supplement a person’s diet.

[0070] The term “skin product” is any product intended to cleanse or beautify the skin. Depending on its purpose and effect, it can be cosmetics or medications.

[0071] The term “ameliorating” refers to any therapeutically beneficial result in the treatment of a disease state, e.g., a skin aliment, lessening in the severity or progression, remission, or cure thereof.

[0072] The term “sufficient amount” means an amount sufficient to produce a desired effect, e.g., an amount sufficient to change skin health condition of a subject.

[0073] The term “therapeutically effective amount” is an amount that is effective to ameliorate a symptom of a disease. A therapeutically effective amount can be a “prophylactically effective amount” as prophylaxis can be considered therapy.

[0074] It must be noted that, as used in the specification and the appended claims, the singular forms “a,” “an” and “the” include plural referents unless the context explicitly dictates otherwise.Overview

[0075] Due to people’s awareness of good skin health, skin products have been massively increased but still cannot fill the gap in improving skin health on an individual level. To address the unique needs of an individual’s skin, various elements that affect the skin’s properties, such as e.g., genetic factors, immune function, oxidative stress, collagen degradation, elastin degradation can be investigated for purposes of determining a customized skin regimen.

[0076] Reference is made to FIG. 1 which depicts a system overview for determining a customized skin regimen for an example individual 110, in accordance with an embodiment. FIG. 1 introduces an individual 110 who may undergo one or more assessments 120 to determine factors that are informative for determining a customized regimen. As described herein, example factors include one or more of individual’s demographics, phenotypic skin appearance, and concerns of the individual (e.g., as determined through a skin questionnaire).IPTS / 200163675.3 24Attorney Docket No.: VIB-030WG

[0077] Genetics is highly implicated in skin aging. Skin aging is a gradual phenomenon characterized by wrinkling, loss of elasticity, laxity, rough-textured appearance, etc. Skin aging is based on both intrinsic and extrinsic factors. Intrinsic skin aging (e.g., chronological aging) may be caused by genetics, cellular metabolism, hormones, and metabolic processes. This process is mainly characterized by functional alterations rather than by overall morphological changes. For example, dry and pale skin with fine wrinkles may indicate a certain degree of laxity and a variety of benign neoplasms. Exogenous or extrinsic factors affecting skin aging may include chronic light exposure, pollution, ionizing radiation, chemicals, toxins, and lifestyle factors (e.g., smoking, sleeping patterns, diet, and daily skincare habits). Extrinsic skin aging is also referred to as photoaging with visible manifestations including coarse wrinkles, solar elastosis, pigment irregularities, etc. Contrary to intrinsic skin aging, extrinsic skin aging is characterized by prominent morphologic and physiologic changes and may result in premature aging of the skin. Extrinsic aging accounts for about 80% of visible skin aging with the signs superimposing the signs of intrinsic skin aging at chronically exposed areas of the body.

[0078] The sign of wrinkles in extrinsic skin aging or photoaging relates to the weakening bond between the dermis and epidermis, which may be caused by marked loss of fibrillinpositive structures and reduced content of collagen type VII (Col-7). The distribution of collagen is altered in older skin with an increased ratio of Col-3 to Col-1. Glycosaminoglycans (GAGs), the primary moisture-retaining dermal skin matrix constituents, may be associated with abnormal elastotic material and thus be unable to function effectively. Assessing these fundamental components may help with understanding the status of one’s skin.

[0079] Lifestyle factors such as nutrient intake also play a major role in skin health. Nutritional antioxidants including vitamin C, vitamin E, carotenoids, copper, and selenium may promote skin health by scavenging free radicals. For example, free radicals generated from endogenous metabolic pathways or exogenous factors may lead to oxidative stress, where the exogenous factors include at least exposure to UV radiation, ionizing radiation, pollution, alcohol intake, or smoking. Oxidative stress results in the loss of functional characteristics and regenerative potential, exacerbating skin aging. Sleep routine is another important factor affecting skin health since good sleep routines contribute to lower trans- epidermal water loss, better skin recovery, and lower intrinsic skin aging scores.

[0080] Given that various endogenous and exogenous factors are affecting skin conditions, the present disclosure proposes methods and protocols that comprehensively assess skin IPTS / 200163675.3 QCAttorney Docket No.: VIB-030WO health based on factors such as an individual’s demographics, phenotypic skin appearance, and concerns of the individual (e.g., as determined through a skin questionnaire) to create a customized skincare regimen, thereby effectively improving an individual’s skin health.

[0081] In some embodiments, the methods described herein measure and evaluate the phenotypic appearance of an individual’s skin. In some embodiments, a digital system is used to analyze the phenotypic features of the skin.

[0082] In some embodiments, a ‘Skin Health’ questionnaire is also designed to gauge the individual’s skin concerns, lifestyle factors, health comorbidities, and skincare goals. The methods provided herein take the results from the biomarker and genetics tests along with the inferences from the questionnaire to provide a customized skin regimen. The methods may include providing customized skin products, dietary and lifestyle suggestions, skincare suggestions, and recommendations for regular skin monitoring strategies.

[0083] FIG. 1 further introduces a skin regimen system 130. Generally, the skin regimen system 130 analyzes the various factors and determines a customized skin regimen 140 that is customized for the individual 110. Example compositions of customized skin regimens are disclosed herein. In various embodiments, the customized skin regimen is provided to the individual 110. For example, the individual 110 can self-apply the customized skin regimen e.g., topically.Example Factors for Determining Customized Skin Regimen

[0084] FIG. 2 provides an overview of the various aspects of skin that are assessed to determine the customized skin regimen disclosed herein. Customized skin regimens, including products, supplements, and lifestyle practices, may be created based on factors such as demographics, phenotypic assessment, and experienced symptoms from the skin questionnaire to tailor the skincare routine for an individualDemographics

[0085] The effect of demographics can be considered and addressed in the methods disclosed herein. Demographics can be a component used in providing a customized skin regimen. Changes in demographics such as age and gender can alter a subject’s skin conditions. Thus, demographics can be factored into the evaluation of the skin regimen, for determining topicals applied to a particular area of the skin, for determining supplementing nutrients, and for monitoring the progress of the implemented topicals and dietary / supplement interventions in a subject.IPTS / 200163675.3 26Attorney Docket No.: VIB-030WO

[0086] An individual’s age is a critical factor affecting skin health. Advancing age is associated with structural and functional changes in extracellular matrix components such as collagens, elastin, and proteoglycans that are required to provide tensile strength, elasticity, and hydration to the skin. The accompanied phenotypic changes are loss of plump and smooth skin, visible veins and bone structure, and increased scarring.

[0087] Gender is another key factor influencing skin health. An individual’s skin is influenced by sex-related differences in anatomy, physiology, epidemiology, and the manifestations of several diseases. Skin parameters such as hydration, trans epidermal water loss, sebum, microcirculation, pigmentation, and thickness are generally higher in men while skin pH is higher in women. These differences may be related to hormones. For example, sebum content can be elevated in men because sebum is highly influenced by sex hormones.

[0088] These sex-related differences may also play a role in disease susceptibility with infectious diseases being presented more in men but psychosomatic problems, pigmentary disorders, certain autoimmune and allergic diseases being more prevalent among women. However, the mechanisms that underlie sex-related differences in skin diseases are yet to be elucidated.

[0089] In some embodiments, the methods disclosed herein further comprise obtaining or having obtained demographics of the subject, and determining the customized skin regimen for the subject based on the demographics of the subject.

[0090] In some embodiments, the demographics comprise one or more of an age or gender of the subject.Skin Questionnaire

[0091] Individuals have various concerns as well as goals with respect to their skin. Dermatology studies state that patients’ participation in medical decision-making has been associated with higher satisfaction with their care, which results in higher compliance to skin regimens and better skin health outcomes. Therefore, individuals’ concerns must be taken into consideration, and their needs must be met while creating customized products for individuals.

[0092] In some aspects, a skin questionnaire is employed to query an individual’s concerns and needs. The questionnaire addresses various factors such as skin goals, type of skin, sun exposure, and skin proneness to external factors, sensitivity to skin products, etc. It also takes into account whether individuals are undergoing or have undergone skin treatments or cosmetic procedures because certain treatments and cosmetic procedures may alter the skin’sIPTS / 200163675.3 27Attorney Docket No.: VIB-030WO structure and composition, which can in turn affect the skin’s ability to absorb and react to skincare products.

[0093] The skin questionnaire can assist with the selection of suitable skin topical and / or supplement forms to ameliorate certain symptoms and overall improve the subject’s skin health. The skin questionnaire may comprise the following questions: if any of the following goals was a primary goal for the subject’s skin: UV protection, anti- wrinkling, antipigmentation, moisturization, radiant complexion; if the subject’s skin was dry; if dry, was the skin mild dry, very dry, or extremely dry; if the subject had specific oily areas on his / her face while the rest of the areas may experience a certain level of dryness; if the subject’s skin was prone to acne; the amount of time (1 hour, 1-2 hours, or > 2 hours) the subject got sun exposure every day; if the subject has ever or is currently receiving skin treatments; if receiving or has received skin treatments, list the treatments; if the subject has stinging or burning after applying any / most skin products; if the subject has excessive scratching, excessive peeling, pus and oozing; if the subject has excessive scratching, excessive peeling, pus and oozing, then see a dermatologist; any external factors affecting the subject’s skin including sun & humidity, wind & cold, or others; if the subject has a proper sleep cycle; if the subject noticed fine lines or wrinkles on the skin; if the subject noticed fine lines or wrinkles, the depth of the wrinkles; how firm and plump the subject’s skin felt when touched by the subject; if the subject’s skin was prone to acne; if the subject experienced stinging or burning sensations on the skin; if the subject noticed uneven skin tone or dark spots on the skin; if the subject’s skin was dry; how the subject’s skin felt after cleansing, was the skin tight, normal, hydrated; the amount of exposure of the subject’s skin to high humidity or wind; the amount the subject’s skin was exposed to sun / light per day; the amount the subject used sunscreen or sun protection (e.g., SPF); the amount the subject experiences puffiness or swelling of the subject’s skin, particularly the skin around the eyes or face.

[0094] The questionnaire can help determine the presence of complications or symptoms associated with altered topical and / or supplement levels, susceptibility to side effects that may be associated with topicals and / or supplements, presence of comorbidities and their symptoms, or ongoing medication usage by the subject. The questionnaire can assess these aspects using direct questions which could be answered with either a ‘yes’ or a ‘no.’ The questionnaire can also receive the subject’s selections for certain questions.

[0095] In some embodiments, a grading system can be further applied to generate a questionnaire score for the skin questionnaire. Points can be assigned to each selected answer, as illustrated in Table 1. For example, if the question is ‘How often do you notice IPTS / 200163675.3 noAttorney Docket No.: VIB-030WO fine lines or wrinkles on your skin,’ the answer can be ‘Never,’ ‘Occasionally,’ ‘Frequently,’ and ‘Always.’ The four different answers have respective points of 1, 2, 3, and 4. For other questions included in the questionnaire, each answer also has a corresponding point assigned in advance. Based on the answers feedback from the questionnaire, one or more questionnaire scores can be then generated. For example, if the questions are categorized into different categories, a questionnaire score may be obtained for each categories (e.g., sum of the points corresponding to the selected answers to all questions included in the category). In some embodiments, an overall questionnaire score can be generated based on the selected answers to all questions included in the questionnaire.

[0096] Responses to the skin questionnaire or the determined questionnaire score(s) can determine appropriate suggestions for topicals, supplements, and lifestyle of the subject. Table 2 provides exemplary responses for the skin questionnaire and the customized topical, supplement, and lifestyle recommendations.

[0097] For example, if an individual aims to seal the moisture of his / her skin, different forms of topicals are available to help the individual achieve his / her goal. Hyaluronic acid can act as a barrier to prevent water loss through evaporation, reduces trans epidermal water loss (TEWL), and improves the skin’s ability to retain moisture. Similarly, to prevent dryness and dehydration, glycerin can be applied to create a thin, occlusive layer to help seal in moisture and prevent water loss through evaporation, shea butter resembles the natural lipids found in the skin to enhance moisture retention, while jojoba oil resembles the natural sebum to form a non-greasy protective barrier on the skin’s surface to prevent trans epidermal water. In the meantime, the individual is also recommended to intake supplements such as hyaluronan, ceramides, and collagen to incorporate with the above-mentioned skin barriers to strengthen the skin and improve moisture retention. Lastly, if the individual is taking long hot baths, he / she may want to take quicker shower with colder water. If the individual is not using a humidifier, he / she may try to use it. This kind of lifestyle suggestions as well as the use of topicals and / or supplements can be personalized and used by specific persons to meet their specific skin needs.

[0098] In general, the combination of skin biomarker testing, demographic considerations, and the skin questionnaire can enable improving the individual’s overall skin health.

[0099] In some embodiments, the methods disclosed herein further comprise obtaining or having obtained one or more responses to a skin questionnaire from the subject and determining the customized skin regimen for the subject based on the one or more responses from the subject. The customized skin regimen includes one or more suggestions for IPTS / 200163675.3 -)QAttorney Docket No.: VIB-030WO topicals, supplements, or lifestyles determined based on the one or more responses, and the one or more suggestions can be selected from Table 2.

[0100] In some embodiments, the skin questionnaire comprises one or more questions related to skin goals, type of skin, sun exposure, or skin proneness to external factors.Phenot pic Assessment

[0101] The phenotypic appearance of the skin is an obvious indicator of skin health, which is another factor considered and addressed in the methods disclosed herein. A visual evaluation may provide the status of the skin and also represent tangible improvements expected by individuals. Such visual evaluations help with addressing visible skin concerns, and have widely been used in diagnosis as well as experimental dermatology. However, a crucial, visual assessment can be subjective and differs from one assessor to the other. To overcome this drawback, a digital system is proposed herein in this disclosure to analyze the phenotypic features of the skin.

[0102] In some embodiments, the system disclosed herein may involve capturing images of an individual’s skin. The captured image can be of the individual’s skin from any anatomical location of the individual. In various embodiments, the captured image is of the individual’s face. These images may be taken at different angles. For example, the images can be taken from the front of the face and from two sides of the face. Using the images, the inbuilt system may grade the severity of each phenotypic parameter. A consensus on the degree of severity may be determined with the help of experts in the field. In some embodiments, the system disclosed herein may provide a questionnaire to an individual in the phenotypic appearance assessment, as described in the above ‘Skin Questionnaire’ section. Based on the feedback from the questionnaire, the inbuilt system may grade the severity of each phenotypic parameter.

[0103] In some embodiments, the phenotype score is based on the combination of the image and the questionnaire.

[0104] Table 3 illustrates an exemplary grading system for grading the severity of phenotypic parameters from seven different categories, namely, an anti-aging and wrinkle reduction category, a lymphatic drainage category, a skin firming and elasticity category, a brightening and pigmentation category, a UV / oxidative damage / DNA / cell damage category, an anti-inflammatory and soothing category, and a hydration and skin barrier repair category. As illustrated in Table 3, the inbuilt grading system includes a picture-based grading algorithm and a questionnaire-based algorithm. The picture-based grading algorithmIPTS / 200163675.3 30Attorney Docket No.: VIB-030WO provides a scale of 1-10 (where 1 is the best and 10 is the worst) for each of the seven categories based on the image evaluation from different aspects. The questionnaire-based algorithm provides a score for each category based on the information collected form the questionnaire. As can be seen in Table 3, instead of the scale of 1-10 for all seven categories, the questionnaire-based algorithm provides different scales for different categories, for example, a scale of 0-3 for ‘lymphatic drainage’, ‘skin firming and elasticity’, and ‘brightening and pigmentation’, a scale of 0-6 for ‘anti-aging and wrinkle reduction’, ‘UV / Oxidative Damage / DNA / Cell damage’, and, ‘anti-inflammatory and soothing’, and a scale of 0-8 for ‘hydration and skin barrier repair”.

[0105] In some embodiments, the inbuilt system disclosed herein further generates a phenotype treatment category for each of the seven categories. For example, based on the points obtained from the picture-based grading and questionnaire-based grading (e.g., the sum of the two grading outcomes), a phenotype treatment category is further determined for the subject under the assessment for each of the seven categories. Table 4 illustrates an exemplary grading principle for determining the phenotype treatment category of a subject under the assessment. In the exemplary grading illustrated in Table 4, the phenotype treatment category of the subject under the assessment can be determined to have a moderate treatment category phenotype or severe treatment category phenotype. However, it should be noted that the phenotype treatment category (i.e., moderate or severe) can have other different ranges, which is not limited in the disclosure. In some embodiments, the determined phenotype treatment category for different categories may be different, which can provide information which category(ies) should be focused when determining the customized topical, supplements and lifestyle suggestions. For example, if ‘brightening and pigmentation’ has a determined phenotype treatment category of “severe” while all other six categories have a determined phenotype of “moderate,” the determined customized topical, supplements and lifestyle suggestions are more focused on the skin brightening and pigmentation.

[0106] Table 5 shows exemplary suggestions for topical, supplements, and lifestyles, which are generated based on phenotypic assessment over a set of phenotypic parameters such as wrinkles, periorbital- around eyes, etc. The suggestions may be determined based on the graded severity of each phenotypic parameter. For example, when determining topical supplementation, a higher severity may cause the system to provide a higher concentration of topical ingredients. It should be noted, however, that an increase in topical ingredients will only take place up to one or more safe, advisable limits.IPTS / 200163675.3 31Attorney Docket No.: VIB-030WO

[0107] In some embodiments, the methods disclosed herein further comprise obtaining or having obtained an image of a face from a subject, grading severities of one or more phenotypic parameters for the face of the subject based on the image, and determining the customized skin regimen for the subject based on the severity of the one or more phenotypic parameters. In some embodiments, the grading is point-based and have a scale of 1-10 where 1 represents the best and 10 represents the worst.

[0108] In some embodiments, the methods disclosed herein further comprising obtaining or having obtaining feedback for a questionnaire sent to a subject, grading severities of one or more phenotypic parameters for the subject based on the feedback of the questionnaire, and determining the customized skin regimen for the subject based on the severity of the one or more phenotypic parameters.

[0109] In some embodiments, the methods disclosed herein further comprising obtaining or having obtaining a phenotype score for one or more categories for a subject and determining the customized skin regimen for the subject based on the phenotype score of the one or more categories. In one example, the aforementioned phenotype treatment category may be used as the phenotype score for each of the seven categories described above.

[0110] In some embodiments, the phenotypic parameters comprise one or more of wrinkles, periorbital- around eyes (i.e., puffy eyes), nasolabial folds (i.e., laugh lines), worry lines, uneven skin tone or pigmentation, or age spots (i.e., liver spots). In some embodiments, the phenotypic parameters are categorized into seven different categories as shown in Table 3 and Table 4.

[0111] In some embodiments, determining the phenotype score for the skin activity category comprises determining a first value from the image of the subject and a second value from a questionnaire including a set of questions related to the skin activity category.

[0112] In some embodiments, determining the phenotype score for the skin activity category comprises determining a phenotype treatment category (i.e., “moderate” or “severe”) for the skin activity category by getting a sum of the first value determined from the image and the second value determined from the questionnaire and determining the phenotype treatment category (i.e., “moderate” or “severe”) for each category based on the sum of the first value and the second value.

[0113] Table 6 shows exemplary suggested ranges for topicals and / or supplements for use in the composition to be applied to improve skin health, wherein the suggested ranges are generated based on the assessed phenotype treatment category (i.e., “moderate” or “severe”) determined for each of the seven categories as described hereinabove.IPTS / 200163675.3 32Attorney Docket No.: VIB-030WGMethods for Determining Customized Skin Regimen and Compositions of Customized Skin Regimens

[0114] Disclosed herein are methods for determining customized skin regimens for individuals based on factors (e.g., demographic, questionnaire, and phenotype) described herein.

[0115] Customized formulas can be prepared in bulk quantities to address common skin phenotypes. Using data collected from the customer’s images and questionnaire, a phenotype assessment is performed and the subject can be assigned a numerical value for each phenotypic category (e.g., lymphatic drainage, skin firming and elasticity, anti-aging and wrinkle reduction, brightening and pigmentation, UV / oxidative damage / DNA / cell damage, anti-inflammatory and soothing, hydration and skin barrier repair). Using the output from the phenotype assessment, the subjects can be ranked in each of 7 categories. The ranking in each of the 7 categories can be rated as Moderate or Severe based on the numerical score, e.g., a score of 1-7 is Moderate, while a score of 8-18 is severe, as shown in Table 4. Individual skin care formulations for the combination of moderate and severe phenotypes can be premade resulting in e.g., 128 pre-made formulations that can be given to subjects.Example Methods for Determining Customized Skin Regimen

[0116] Disclosed herein are methods for determining customized skin regimens for individuals based on factors described herein. In various embodiments, methods can involve determining a customized skin regimen that includes particular quantities of one or more of the active element provided in any of Tables 6-8. In various embodiments, the customized skin regimen includes a set of base compound, as illustrated in Table 8. Each base compound has a corresponding range, and these base compounds are classified into six categories e.g., polymer / solubilizing / gelling / emulsifier agents, humectant and emollient, preservative, chelating agent, penetration enhancers, and parfum. For a customized skin regime, at least one base compound is selected from each category. The exact amount of each selected base compound can be adjusted if necessary. In some embodiments, more than one base compound can be used, e.g., at least two, three, four, five, or more base compounds.

[0117] In some embodiments, the customized skin regimen includes a one or more of Cellulose, Algin, Xanthan Gum, PEG Macademia Glycerides, Polyacrylate Crosspolymer 6, Ammonium Acryloyldimethyltaurate / VP Copolymer, Caprylyl Glycol, Lecithin, Carbomer, Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Seppic SepiZen (Polyacrylate Crosspolymer-6), Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer (Sepinov), Aristoflex (Ammonium Acryloyldimethyltaurate / VPIPTS / 200163675.3 33Attorney Docket No.: VIB-030WGCopolymer), Clearthix S (Algin and Cellulose Gum), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Glycerin, Sorbitol, Sorbitol 70, Sodium Hylauronate, SodiumHyaluronate (Ultra Low Molecular Weight), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Sodium Hyaluronate (Medium Molecular Weight), PEG- 16 Macadamia Glycerides, Phenoxyethanol, Ethylhexylglycerin, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Phytate, Disodium EDTA, Butylene Glycol, Pentylene Glycol, Sodium Lauryl sulfate, Dimethylisosorbide, or parfum.

[0118] In various embodiments, methods for determining customized skin regimens for individuals comprises analyzing one or more factors from the individual described herein. In particular embodiments, methods for determining customized skin regimens for individuals comprises analyzing one or more of an individual’s (A) demographics, (B) phenotypic assessment, and (C) skin questionnaire information. In some embodiments, methods for determining customized skin regimes involve analyzing phenotypic assessment (e.g., one or more of an image and / or a skin questionnaire).

[0119] In various embodiments, methods for determining customized skin regimens involves obtaining or having obtained information about an individual’s demographics, phenotypic data (e.g., an image), and / or skin questionnaire information.

[0120] In particular embodiments, methods for determining customized skin regimens involves obtaining or having obtained an image captured of the subject’s skin. Phenotypic data can be obtained by performing methods described herein under the “Phenotypic Assessment” heading. Skin questionnaire information can be obtained by performing methods described herein under the “Skin Questionnaire” heading.

[0121] In various embodiments, methods for determining customized skin regimens involves obtaining or having obtained such information for each of one or more skin activity categories, examples of which include an anti-aging and wrinkle reduction category, a lymphatic drainage category, a skin firming and elasticity category, a brightening and pigmentation category, a UV / oxidative damage / DNA / cell damage category, an antiinflammatory and soothing category, and a hydration and skin barrier repair category. For example, methods for determining customized skin regimens involves obtaining or having obtained phenotypic data and / or skin questionnaire information for each of one or more skin activity categories. Examples of skin activity categories, as well as active elements of those skin activity categories, are described in Tables 6 to 7. As an example, assume 7 differentIPTS / 200163675.3 34Attorney Docket No.: VIB-030WO skin activity categories. Thus, methods may involve obtaining or having obtained phenotypic data and / or skin questionnaire information for each of the 7 different skin activity categories.

[0122] In various embodiments, certain information can be used across different skin activity categories. As another example, phenotypic information (such as an image) or questionnaire information can be used across different skin activity categories. Thus, a single image and / or a single questionnaire can be sufficient and methods need not involve obtaining multiple images and / or multiple questionnaires.

[0123] In various embodiments, methods for determining customized skin regimens involves determining one or more of a phenotype score and a skin questionnaire score for the skin activity category for the subject using the one or more of phenotypic information and skin questionnaire information. Generally, for an example subject, the phenotype score and skin questionnaire score for each skin activity category may be different. Thus, a customized skin regimen including specifically determined amounts of individual elements can be determined for the subject. Each of the phenotypic information and skin questionnaire information are described in turn.

[0124] Referring to the phenotypic information, it can be used to determine a phenotype score (also referred to herein as a “Phenotypic Treatment Category (z.e., ‘moderate’ or ‘severe’)”) that is useful for determining quantities of active elements to be included in a customized skin regimen. In various embodiments, the phenotypic information includes an image of the individual, such as an image of the individual’s skin. In particular embodiments, the phenotypic information includes an image of the individual’s face. In various embodiments, methods include analyzing the phenotypic information to convert the phenotypic information into a quantitative score that can be used, at least in part, to determine the phenotype score. In some embodiments, analyzing the phenotypic information can involve manually analyzing the phenotypic information and assigning quantitative scores for each of the skin activity categories. In some embodiments, analyzing the phenotypic information can involve applying an automated process (e.g., a machine learning or image recognition process) to analyze the phenotypic information and assigning quantitative scores for each of the skin activity categories. In various embodiments, the quantitative score can be between a minimum of 1 and a maximum of 10. For example, a score of 1 can be indicative of an optimal condition for the skin activity category whereas a score of 10 can be indicative of a worst condition for the skin activity category. An example of quantitative scores from an image for individual skin activity categories is shown in Table 3.IPTS / 200163675.3 35Attorney Docket No.: VIB-030WO

[0125] Additionally, referring to the skin questionnaire information, it can be used to determine a phenotype score (also referred to herein as a “Phenotypic Treatment Category (z.e., ‘moderate’ or ‘severe’)”) that is useful for determining quantities of active elements to be included in a customized skin regimen. In various embodiments, methods include analyzing the skin questionnaire information to convert provided answers into a quantitative score that can be used, at least in part, to determine the phenotype score. In various embodiments, the quantitative score can be between a minimum of 1 and a maximum of 3. In various embodiments, the quantitative score can be between a minimum of 1 and a maximum of 6. In various embodiments, the quantitative score can be between a minimum of 1 and a maximum of 8. An example of quantitative scores from a questionnaire for individual skin activity categories is shown in Table 3. Furthermore, example questions of the questionnaire are shown in Table 1 along with assigned points corresponding to particular answers.

[0126] In various embodiments, for a particular skin activity category, methods involve combining the quantitative score from the phenotypic information and the quantitative score from the questionnaire to generate the phenotype score (corresponding to the phenotype treatment category of “moderate” or “severe”). For example, methods can involve arithmetically combining (e.g., summing) the quantitative score from the phenotypic information and the quantitative score from the questionnaire. In various embodiments, the arithmetically combined quantitative scores are mappable to a corresponding phenotype score, which correspond to a phenotype treatment category of “moderate” or “severe.” For example, if the arithmetically combined quantitative score falls within a particular score range, then the score is mapped to a corresponding phenotype score for that particular score range, which correspond to a phenotype treatment category of “moderate” or “severe.” An example is shown in Table 4 where each points range (for a particular skin activity category) corresponds to a particular phenotype score (e.g., phenotype treatment category (z.e., “moderate” or “severe”) as referred to in Table 4).

[0127] In various embodiments, fixed values for each active element in a skin activity category can range between 0 and 10%. For example, a fixed value can be any of 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%,3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%,4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%,5.8%, 5.9%, 6.0%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7.0%, 7.1%,7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8.0%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%,IPTS / 200163675.3 IAttorney Docket No.: VIB-030WO8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, 10.0%. As an example, Table 7 shows the fixed values for active elements in the anti-aging and wrinkle reduction skin activity category, given a treatment category (e.g., “moderate” or “severe”). Although Table 7 depicts one example of fixed values of active elements, one skilled in the art would understand that there are various other combinations of fixed values that can be used (e.g., between 0 and 10%) for the various active elements.

[0128] Given fixed values for each active element in a skin activity category for each phenotype treatment category (e.g., “moderate” or “severe”), methods can involve combining certain fixed values for each active element. In various embodiments, for each active element of the plurality of active elements, methods involve combining fixed values across one or more of the phenotype score and skin questionnaire score to obtain the phenotype treatment category (z.e., “moderate” or “severe”) and to determine a percentage of the element to be included in the customized skin regimen.Customized Skin Regimens and Methods of Use

[0129] In one aspect, provided herein are methods for treating a skin condition of a subject, the method comprising administering a customized skin regimen (e.g., a formulation) to the skin of the subject, wherein the customized skin regimen was determined for the subject by: for one or more skin activity categories, each skin activity category comprising at least one compound being considered for inclusion in the customized skin regimen: obtaining or having obtained one or more images captured of the subject’s skin; determining a phenotype score for one or more skin activity categories for the subject using the one or more images; assigning a phenotype treatment category to each of the one or more skin activity categories for the subject based on the phenotype score; and for the phenotype treatment category, determining a fixed value for each of a plurality of elements of the skin activity category using the corresponding treatment category.

[0130] In some embodiments, the customized skin regimen is administered one or more times to the subject. In some embodiments, the customized skin regimen is administered one time, two times, three times, four times, five times, six times, seven times, eight times, nine times, ten times or more.

[0131] In some embodiments, the customized skin regimen is additionally administered one or more times to the subject without re-determining the customized skin regimen.

[0132] The customized skin regimen (e.g., formulation) can comprise any topical or supplement (z.e., active ingredient) provided in Tables 2, 5, 6, 7 or 9-32. In someIPTS / 200163675.3 37Attorney Docket No.: VIB-030WG embodiments, the skin care regimen comprises one or more topical or supplement (z.e., active ingredient) selected from Tables 2, 5, 6, 7 or 9-32. In some embodiments, the skin care regimen comprises one or more, two or more, three or more, four or more, five or more, six or more, seven or more, eight or more, nine or more, ten or more, eleven or more, twelve or more, thirteen or more, fourteen or more, fifteen or more, sixteen or more, seventeen or more, eighteen or more, nineteen or more, or twenty or more topical or supplement (z.e., active ingredient) selected from Tables 2, 5, 6, 7 or 9-32.

[0133] Table 7 provides additional information about the topicals and / or supplements (z.e., active ingredients) for use in the composition to be applied to improve skin health. Provided in Table 7 is the name of the topical and supplement (z.e., active ingredient), an exemplary vendor, the sequence or chemical structure of the topicals and supplements (z.e., active ingredients), the CAS number, and if available, the INCI name.

[0134] The customized skin regimen can also comprise any of the base ingredients provided in Table 8. In some embodiments, the skin care regimen comprises one or more base ingredients selected from Table 8. In some embodiments, the skin care regimen comprises one or more, two or more, three or more, four or more, five or more, six or more, seven or more, eight or more, nine or more, ten or more, eleven or more, twelve or more, thirteen or more, fourteen or more, fifteen or more, sixteen or more, seventeen or more, eighteen or more, nineteen or more, or twenty or more base ingredients selected from Table 8.

[0135] Table 8 provides the category and names of the base ingredients for use in the composition to be applied to improve skin health.

[0136] In some embodiments, the composition comprises a topical skin care composition or medication. Exemplary topicals include, but are not limited to, vitamin C, peptides, retinoids, copper peptides, hyaluronic acid, niacinamide, alpha hydroxy acids (AHA), ginseng, green tea extract, and capsaicin. In some embodiments, the composition comprises a supplemental skin care composition. Exemplary supplemental compositions include, but are not limited to, collagen and collagen peptides, vitamin C, omega-3 fatty acids, copper, zinc, omega-3 fatty acids, proline, glycine, vitamin E, curcumin, resveratrol, Eicosapentaenoic acid, Docosahexaenoic acid, vitamin D, probiotics, silicon, ginseng, aloe vera.

[0137] Peptides that can be used in the composition and method described herein are provided in Table 7. In some embodiments, the peptide is one or more of Hexapeptide- 11, GHK-Cu, Palmitoyl Pentapeptide-4 (Pal-KTTKS), Palmitoyl Tetrapeptide-7 (Pal-GQPR), Dipeptide-2, Palmitoyl Pentapeptide-4 (Matrixyl), decapeptide- 12, Dipeptide IPTS / 200163675.3Attorney Docket No.: VIB-030WGDiaminobutyroyl Benzylamide Diacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Acetyl Tetrapeptide-5, Heptapeptide-4, Acetyl Hexapeptide-51 Amide, Acetyl Hexapep tide-30, Acetyl Hexapeptide- 8 (Argireline), acetyl hexapeptide-3 (Argireline), Acetylarginyltryptophyl Diphenylglycine, Acetyl Hexapeptide-37, Hexapeptide- 10, Acetyl Octapeptide-3, Tetrapeptide- 1, Tetrapeptide- 2, Acetyl Tetrapeptide-2, Acetyl Hexapeptide-38, Acetyl Dipeptide-3 Aminohexanoate, Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide-49, Pentapeptide 18, Tripeptide 29, Nonapeptide- 1, Tripeptide 5, Palmitoyl Tripeptide-5, Diaminopropionoyl (DAP) Tripeptide- 33, beta glucan, and / or bacillus extract, Hexapeptide- 2, Hexapeptide-11, Palmitoyl Hexapeptide- 12, Palmitoyl Oligopeptide, Myristoyl Pentapeptide-8, Oligopeptide- 10, Oligopeptide-24, Oligopeptide-34, Oligopeptide-51, Decapeptide-4, Syn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyloyl Hydroxy threonine and Palmitoyl Dipeptide- 6 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 11, Acetyl Tetrapeptide- 15, Acetyl Tetrapeptide-22, Acetyl Tetrapeptide-40, Acetyl Heptapeptide- 1, Reproage (Disodium Phosphate, Acetyl Hexapeptide- 8, Sodium Phosphate, Caprylyl Glycol), Acetyl Dipeptide- 1 Cetyl Ester, Tripeptide-9 Citrulline (dGlyage), Argirelox™ (Pentapeptide 18 and Argireline), Synake, Palmitoyl Pentapeptide 38, Sodium pyrrolidone carboxylic acid (pea), Dipeptide Diaminobutyroyl Benzylamide Diacetate.

[0138] Retinoids that can be used in the composition and method described herein are provided in Table 7. In some embodiments, the retinoid is one or more of retinol, retinal, tretinoin (retinoic acid), isotretinoin, alitretinoin, adapalene, bexarotene, tazarotene, and / or Trifarotene.

[0139] Omega-3 fatty acids that can be used in the composition and method described herein are provided in Table 7. In some embodiments, the omega-3 fatty acid is one or more of Alpha-linolenic acid (ALA), Eicosapentaenoic acid (EPA), and / or Docosahexaenoic acid (DHA).

[0140] Alpha hydroxy acids (AHAs) that can be used in the composition and method described herein are provided in Table 7. In some embodiments, the Alpha hydroxy acid is one or more of glycolic acid, lactic acid, mandelic acid, and / or citric acid.

[0141] The topical and / or supplemental compositions can be formulated in an appropriate carrier or excipient. Exemplary carriers include, but are not limited to, water, Caprylyl Glycol, butylene glycol, ultra low molecular weight (ulmw) hyaluronic acid, middle molecular weight (MMW) hyaluronic acid, and dimethyl isosorbide.IPTS / 200163675.3 OQAttorney Docket No.: VIB-030WO

[0142] Tables 9-32 provide the compositions of twenty-four exemplary formulations (z.e., customized skin formulations 1-24 or regimes) for use in being applied to patient skin to improve skin health.

[0143] In some embodiments, the customized skin regimen comprises any of the ingredients provided in Tables 9-32. In some embodiments, the skin care regimen comprises one or more ingredients selected from Tables 9-32. In some embodiments, the skin care regimen comprises one or more, two or more, three or more, four or more, five or more, six or more, seven or more, eight or more, nine or more, ten or more, eleven or more, twelve or more, thirteen or more, fourteen or more, fifteen or more, sixteen or more, seventeen or more, eighteen or more, nineteen or more, twenty or more, twenty-one or more, twenty-two or more, twenty-three or more, twenty-four or more, twenty-five or more, twenty- six or more, twenty-seven or more, twenty-eight or more, twenty-nine or more, thirty or more, thirty-one or more, thirty-two or more, thirty-three or more, thirty-four or more, thirty-five or more, thirty-six or more, thirty-seven or more, thirty-eight or more, thirty-nine or more, forty or more, forty-one or more, forty-two or more, forty-three or more, forty-four or more, forty- five or more, forty-six or more, forty-seven or more, forty-eight or more ingredients selected from Tables 9-32. In some embodiments, the customized skin care regimen comprises the composition of Tables 9-32.

[0144] In some embodiments, the customized skin care regimen comprises the composition of Table 9. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Acetyl Hexapeptide-51 Amide (Juveleven™ Peptide Solution), Glycerin, Tripeptide-33 (DAP-Tripeptide-33), Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol, Ferulic Acid, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta- Glucan, Bacillus Ferment (Bacillus Extract), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Panthenol, Copper Tripeptide- 1 (GHK-Cu), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (MMW Hyaluronic Acid), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3). In some embodiments, the customized skin care regimen comprises Water (aqua), Nonapeptide- 1, IPTS / 200163675.3 / i nAttorney Docket No.: VIB-030WOHexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Acetyl Hexapeptide-51 Amide (Juveleven™ Peptide Solution), Glycerin, Tripeptide-33 (DAP-Tripeptide-33), Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol, Ferulic Acid, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta- Glucan, Bacillus Ferment (Bacillus Extract), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Panthenol, Copper Tripeptide- 1 (GHK-Cu), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (MMW Hyaluronic Acid), Pephatight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3). In some embodiments, the customized skin care regimen optionally comprises parfum.

[0145] In some embodiments, the customized skin care regimen comprises the composition of Table 10. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Decapeptide- 12, Nonapeptide- 1, Tripeptide-33 (DAP-Tripeptide-33), Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide- 10 Citrulline (Decorinyl), Hexapeptide- 11, Acetyl Octapeptide-3 (SNAP-8), PEG-16 Macadamia Glycerides, Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Sorbitol (Sorbitol 70), Acetyl Hexapeptide-51 Amide (Juveleven™ Peptide Solution), Glycerin, Copper Tripeptide- 1 (GHK-Cu), Acetyl Tetrapeptide- 15, Butylene Glycol, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D- Panthenol), Dimethyl Isosorbide, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Allantoin, Sodium Hyaluronate (MMW Hyaluronic Acid), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen comprises Water (aqua), Argirelox (Acetyl Hexapeptide-8 and IPTS / 200163675.3Attorney Docket No.: VIB-030WOPentapeptide- 18), Decapeptide- 12, Nonapeptide- 1, Tripeptide-33 (DAP-Tripeptide-33), Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide- 10 Citrulline (Decorinyl), Hexapeptide- 11, Acetyl Octapeptide-3 (SNAP-8), PEG-16 Macadamia Glycerides, Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Sorbitol (Sorbitol 70), Acetyl Hexapeptide- 51 Amide (Juveleven™ Peptide Solution), Glycerin, Copper Tripeptide-1 (GHK-Cu), Acetyl Tetrapeptide- 15, Butylene Glycol, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Dimethyl Isosorbide, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Allantoin, Sodium Hyaluronate (MMW Hyaluronic Acid), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), HydroxyethylAcrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen optionally comprises parfum.

[0146] In some embodiments, the customized skin care regimen comprises the composition of Table 11. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Acetyl Hexapeptide-8 (Argireline), Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Acetyl Octapeptide-3 (SNAP-8), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Hexapeptide- 11, Decapeptide- 12, Hexapeptide-49 (Delisens Solution), Decapeptide-4 (Reproage), Glycerin, Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG-16 Macadamia Glycerides, Tetrapeptide- 2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Syn- TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol, Palmitoyl Hexapeptide-38 (Adifyline), Butylene Glycol, Dimethyl Isosorbide, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide-1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / CaprylIPTS / 200163675.3 42Attorney Docket No.: VIB-030WOGlucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3). In some embodiments, the customized skin care regimen comprises Water (aqua), Acetyl Hexapeptide-8 (Argireline), Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Acetyl Octapeptide-3 (SNAP-8), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Hexapeptide- 11, Decapeptide- 12, Hexapeptide-49 (Delisens Solution), Decapeptide-4 (Reproage), Glycerin, Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG-16 Macadamia Glycerides, Tetrapeptide- 2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Syn- TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol, Palmitoyl Hexapeptide- 38 (Adifyline), Butylene Glycol, Dimethyl Isosorbide, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3). In some embodiments, the customized skin care regimen optionally comprises parfum.

[0147] In some embodiments, the customized skin care regimen comprises the composition of Table 12. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Sorbitol, Nonapeptide- 1, Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide- 30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn- Ake), Glycerin, Acetyl Hexapeptide-8 (Argireline), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide- 2 (Uplevity), Polyacrylate IPTS / 200163675.3 43Attorney Docket No.: VIB-030WOCrosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low Molecular Weight), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Pentapeptide- 3, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Sodium Phytate, Myristoyl Pentapeptide- 8. In some embodiments, the customized skin care regimen comprises Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Sorbitol, Nonapeptide- 1, Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn- Ake), Glycerin, Acetyl Hexapeptide-8 (Argireline), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide-2 (Uplevity), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low Molecular Weight), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Pentapeptide- 3, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Sodium Phytate, Myristoyl Pentapeptide- 8. In some embodiments, the customized skin care regimen optionally comprises parfum.

[0148] In some embodiments, the customized skin care regimen comprises the composition of Table 13. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide-10 Citrulline (Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide- 5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide-2 (Uplevity), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium IPTS / 200163675.3 / | / |Attorney Docket No.: VIB-030WOAscorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low Molecular Weight), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Sodium Phytate, Myristoyl Pentapeptide- 8. In some embodiments, the customized skin care regimen comprises Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide- 10 Citrulline (Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn- Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide-2 (Uplevity), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low Molecular Weight), Ahnfeltiopsis concinna Extract (APT- GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Sodium Phytate, Myristoyl Pentapeptide- 8. In some embodiments, the customized skin care regimen optionally comprises parfum.

[0149] In some embodiments, the customized skin care regimen comprises the composition of Table 14. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide- 10 Citrulline (Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide-2 (Uplevity), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low Molecular Weight), Ahnfeltiopsis concinna Extract (APT-GPF), IPTS / 200163675.3 ,KAttorney Docket No.: VIB-030WOButylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Sodium Phytate, Myristoyl Pentapeptide- 8. In some embodiments, the customized skin care regimen comprises Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide- 10 Citrulline (Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn- Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide-2 (Uplevity), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low Molecular Weight), Ahnfeltiopsis concinna Extract (APT- GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Sodium Phytate, Myristoyl Pentapeptide- 8. In some embodiments, the customized skin care regimen optionally comprises parfum.

[0150] In some embodiments, the customized skin care regimen comprises the composition of Table 15. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide- 10 Citrulline (Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Pentapeptide-4, Dipeptide-2, Magnesium Ascorbyl Phosphate, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha- tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide-2 (Uplevity), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Ammonium Acryloyldimethyltaurate / VP Copolymer IPTS / 200163675.3 A f.Attorney Docket No.: VIB-030WG(Aristoflex), Sodium Phytate. In some embodiments, the customized skin care regimen comprises Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide- 10 Citrulline (Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn- Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Pentapeptide-4, Dipeptide-2, Magnesium Ascorbyl Phosphate, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide-2 (Uplevity), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT- GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex), Sodium Phytate. In some embodiments, the customized skin care regimen optionally comprises parfum.

[0151] In some embodiments, the customized skin care regimen comprises the composition of Table 16. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Tripeptide- 10 Citrulline (Decorinyl), Acetyl Tetrapeptide-5 (Eyeseryl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Magnesium Ascorbyl Phosphate, Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn- Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide-2 (Uplevity), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Clearthix S (Algin and Cellulose Gum), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex), IPTS / 200163675.3 AAttorney Docket No.: VIB-030WGSodium Phytate, Myristoyl Pentapeptide- 8. In some embodiments, the customized skin care regimen comprises Water (aqua), Tripeptide- 10 Citrulline (Decorinyl), Acetyl Tetrapeptide-5 (Eyeseryl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Magnesium Ascorbyl Phosphate, Acetyl Hexapeptide- 30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapep tide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide-2 (Uplevity), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Clearthix S (Algin and Cellulose Gum), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex), Sodium Phytate, Myristoyl Pentapeptide- 8. In some embodiments, the customized skin care regimen optionally comprises parfum.

[0152] In some embodiments, the customized skin care regimen comprises the composition of Table 17. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide-8 (Argireline), Acetyl Octapeptide-3 (SNAP-8), Glycerin, Hexapeptide-11, Decapeptide- 12, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide- 5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), PEG-16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Palmitoyl Pentapep tide-38, Butylene Glycol, Dimethyl Isosorbide, Acetyl Hexapeptide- 38 (Adifyline), Tripeptide-33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta- Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and IPTS / 200163675.3 A OAttorney Docket No.: VIB-030WOPhenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Ferulic Acid, Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate, Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen comprises Water (aqua), Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide-8 (Argireline), Acetyl Octapeptide-3 (SNAP-8), Glycerin, Hexapeptide- 11, Decapeptide- 12, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), PEG- 16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Syn-TacksSyn- Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Palmitoyl Pentapeptide-38, Butylene Glycol, Dimethyl Isosorbide, Acetyl Hexapeptide- 38 (Adifyline), Tripeptide-33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta- Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Ferulic Acid, Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate, Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen optionally comprises parfum.

[0153] In some embodiments, the customized skin care regimen comprises the composition of Table 18. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Inyline (Tripeptide- 1 and Palmitoyl Tripeptide- 1 and Palmitoyl Tetrapeptide-7 and Acetyl Dipeptide- 1 Cetyl Ester, Nonapeptide- 1, Acetyl Hexapeptide-30), Hexapeptide-49 (Delisens), Tripeptide-10 Citrulline (Decorinyl), Acetyl Octapeptide-3 (SNAP-8), Hexapeptide- 11, Glycerin, Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, PEG- 16 Macadamia Glycerides, IPTS / 200163675.3 / IQAttorney Docket No.: VIB-030WGTetrapeptide- 2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Sorbitol (Sorbitol 70), Butylene Glycol, Dimethyl Isosorbide, Magnesium Ascorbyl Phosphate, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Clearthix S (Algin and Cellulose Gum), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Caffeine, Ceramide NP (Ceramide 3 / NP), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate. In some embodiments, the customized skin care regimen comprises Water (aqua), Inyline (Tripeptide- 1 and Palmitoyl Tripeptide- 1 and Palmitoyl Tetrapeptide-7 and Acetyl Dipeptide- 1 Cetyl Ester, Nonapeptide- 1, Acetyl Hexapeptide-30), Hexapeptide-49 (Delisens), Tripeptide-10 Citrulline (Decorinyl), Acetyl Octapeptide-3 (SNAP-8), Hexapeptide- 11, Glycerin, Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, PEG-16 Macadamia Glycerides, Tetrapeptide- 2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Sorbitol (Sorbitol 70), Butylene Glycol, Dimethyl Isosorbide, Magnesium Ascorbyl Phosphate, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta- Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Clearthix S (Algin and Cellulose Gum), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Caffeine, Ceramide NP (Ceramide 3 / NP), Ferulic Acid, Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate. In some embodiments, the customized skin care regimen optionally comprises parfum.

[0154] In some embodiments, the customized skin care regimen comprises the composition of Table 19. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Acetyl Hexapeptide- 51 Amide IPTS / 200163675.3Attorney Docket No.: VIB-030WG(Juveleven™ Peptide Solution), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Tripeptide- 33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin Methyl Chaicone, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Ferulic Acid, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen comprises Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Acetyl Hexapeptide-51 Amide (Juveleven™ Peptide Solution), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Tripeptide-33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin Methyl Chaicone, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Ferulic Acid, Pepha- tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), HydroxyethylAcrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen optionally comprises parfum.

[0155] In some embodiments, the customized skin care regimen comprises the composition of Table 20. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Tripeptide-33 (DAP-Tripeptide- 33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus IPTS / 200163675.3 C 1Attorney Docket No.: VIB-030WGExtract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin Methyl Chaicone, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Ferulic Acid, Pepha- tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen comprises Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Tripeptide- 33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin Methyl Chaicone, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Ferulic Acid, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen optionally comprises parfum.

[0156] In some embodiments, the customized skin care regimen comprises the composition of Table 21. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Tripeptide-33 (DAP-Tripeptide- 33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl IPTS / 200163675.3 CQAttorney Docket No.: VIB-030WOGlutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Ferulic Acid, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen comprises Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapep tide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide-38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Tripeptide-33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Ferulic Acid, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen optionally comprises parfum.

[0157] In some embodiments, the customized skin care regimen comprises the composition of Table 22. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide-38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Arginine / Lysine Polypeptide, Tripeptide-33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta- Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), IPTS / 200163675.3 COAttorney Docket No.: VIB-030WOPepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP), Ferulic Acid. In some embodiments, the customized skin care regimen comprises Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Arginine / Lysine Polypeptide, Tripeptide-33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP), Ferulic Acid. In some embodiments, the customized skin care regimen optionally comprises parfum.

[0158] In some embodiments, the customized skin care regimen comprises the composition of Table 23. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Glycerin, Acetyl Hexapeptide-38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Oligopeptide- 10, Tripeptide-33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta- Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide IPTS / 200163675.3 C / 1Attorney Docket No.: VIB-030WO3 / NP), Ferulic Acid. In some embodiments, the customized skin care regimen comprises Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Glycerin, Acetyl Hexapeptide- 38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Oligopeptide- 10, Tripeptide-33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP), Ferulic Acid. In some embodiments, the customized skin care regimen optionally comprises parfum.

[0159] In some embodiments, the customized skin care regimen comprises the composition of Table 24. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide-8 (Argeriline), Acetyl Octapeptide-3 (SNAP-8), Glycerin, Hexapeptide-11, Decapeptide- 12, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide- 5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), PEG-16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Palmitoyl Pentapep tide-38, Butylene Glycol, Dimethyl Isosorbide, Hydroxypropyl Tetrahydropyrantriol (Proxylane), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Acetyl Hexapeptide- 38 (Adifyline), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, IPTS / 200163675.3 CCAttorney Docket No.: VIB-030WGPolyglyceryl-6 Oleate, and Sodium Surfactin), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate, Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen comprises Water (aqua), Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide-8 (Argeriline), Acetyl Octapeptide- 3 (SNAP-8), Glycerin, Hexapeptide- 11, Decapeptide- 12, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapep tide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), PEG- 16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Palmitoyl Pentapep tide-38, Butylene Glycol, Dimethyl Isosorbide, Hydroxypropyl Tetrahydropyrantriol (Proxylane), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Acetyl Hexapeptide-38 (Adifyline), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate, Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen optionally comprises parfum.

[0160] In some embodiments, the customized skin care regimen comprises the composition of Table 25. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Acetyl Hexapeptide-8 (Argireline), Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Glycerin, Acetyl Octapeptide-3 (SNAP-8), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Hexapeptide- 11, Decapeptide- 12, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide- 5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG-16 Macadamia Glycerides, Hydroxypropyl Tetrahydropyrantriol (Proxylane), Tetrapeptide-2 (Uplevity), IPTS / 200163675.3Attorney Docket No.: VIB-030WOAcetyl Tetrapeptide-5 (Eyeseryl), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Palmitoyl Pentapep tide-38, Acetyl Hexapeptide- 38 (Adifyline), Butylene Glycol, Dimethyl Isosorbide, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen comprises Water (aqua), Acetyl Hexapeptide-8 (Argireline), Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Glycerin, Acetyl Octapeptide-3 (SNAP-8), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Hexapeptide- 11, Decapeptide- 12, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide- 5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG-16 Macadamia Glycerides, Hydroxypropyl Tetrahydropyrantriol (Proxylane), Tetrapeptide- 2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Palmitoyl Pentapep tide-38, Acetyl Hexapeptide- 38 (Adifyline), Butylene Glycol, Dimethyl Isosorbide, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen optionally comprises parfum.IPTS / 200163675.3 7Attorney Docket No.: VIB-030WG

[0161] In some embodiments, the customized skin care regimen comprises the composition of Table 26. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Sorbitol (Sorbitol 70), Nonapeptide- 1, Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide-30 (Inyline Solution), Glycerin, Acetyl Hexapeptide-8 (Argireline), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide- 2 (Uplevity), Hexapeptide- 10 (Sirulisene), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Oligopeptide- 10, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Myristoyl Pentapeptide- 8. In some embodiments, the customized skin care regimen comprises Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Sorbitol (Sorbitol 70), Nonapeptide- 1, Tripeptide- 10 Citrulline (Decorinyl), Acetyl Hexapeptide-30 (Inyline Solution), Glycerin, Acetyl Hexapeptide-8 (Argireline), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide- 2 (Uplevity), Hexapeptide- 10 (Sirulisene), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Oligopeptide- 10, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Myristoyl Pentapeptide- 8. In some embodiments, the customized skin care regimen optionally comprises parfum.

[0162] In some embodiments, the customized skin care regimen comprises the composition of Table 27. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Palmitoyl Tripeptide- 1 (Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, IPTS / 200163675.3 COAttorney Docket No.: VIB-030WGAcetyl Tetrapeptide-5 (Eyeseryl), Acetyl Hexapeptide- 30 (Inyline), Nonapeptide- 1, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Acetyl Octapeptide-3 (SNAP-8), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn- Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Pentapeptide-4, Dipeptide-2, Magnesium Ascorbyl Phosphate, Decapeptide-4 (Reproage), Tetrapeptide-2 (Uplevity), Tetrapep tide-30, Macrocystis Pyrifera (Kelp) Extract, Panthenol (D-Panthenol), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Phytate, Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen comprises Water (aqua), Palmitoyl Tripeptide- 1 (Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Acetyl Tetrapeptide-5 (Eyeseryl), Acetyl Hexapeptide- 30 (Inyline), Nonapeptide- 1, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Acetyl Octapeptide-3 (SNAP-8), Amidinobenzyl Benzylsulfonyl D- Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Pentapeptide-4, Dipeptide-2, Magnesium Ascorbyl Phosphate, Decapeptide-4 (Reproage), Tetrapeptide-2 (Uplevity), Tetrapeptide-30, Macrocystis Pyrifera (Kelp) Extract, Panthenol (D-Panthenol), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Phytate, Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen optionally comprises parfum.

[0163] In some embodiments, the regimen comprises the composition of Table 28. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Tripeptide-10 Citrulline (Decorinyl), Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Acetyl Tetrapeptide-5 (Eyeseryl), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-SerylIPTS / 200163675.3 CQAttorney Docket No.: VIB-030WGHomophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapep tide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide-2 (Uplevity), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Hexapeptide- 11, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Phytate, Myristoyl Pentapeptide- 8. In some embodiments, the customized skin care regimen comprises Water (aqua), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Tripeptide-10 Citrulline (Decorinyl), Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Acetyl Tetrapeptide-5 (Eyeseryl), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide- 7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide-2 (Uplevity), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Hexapeptide- 11, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Phytate, Myristoyl Pentapeptide- 8. In some embodiments, the customized skin care regimen optionally comprises parfum.

[0164] In some embodiments, the customized skin care regimen comprises the composition of Table 29. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Glycerin, Nonapeptide- 1, Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Hexapeptide-49, Tetrapeptide-30, Tripeptide-10 Citrulline (Decorinyl), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Palmitoyl Tetrapeptide-7, Dipeptide-2, Magnesium Ascorbyl Phosphate, Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and IPTS / 200163675.3Attorney Docket No.: VIB-030WGPentylene Glycol and Citric Acid), Tripeptide-33 (DAP-Tripeptide-33), Macrocystis Pyrifera (Kelp) Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Acetyl Tetrapeptide- 15, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Decapeptide-4 (Reproage peptide), Tetrapeptide- 2 (Uplevity), Palmitoyl Pentapeptide-4, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Ferulic Acid, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT- GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex), Allantoin, Clearthix S (Algin and Cellulose Gum), Sodium Phytate. In some embodiments, the customized skin care regimen comprises Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Glycerin, Nonapeptide- 1, Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Hexapeptide-49, Tetrapeptide-30, Tripeptide-10 Citrulline (Decorinyl), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Palmitoyl Tetrapeptide-7, Dipeptide-2, Magnesium Ascorbyl Phosphate, Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Tripeptide-33 (DAP-Tripeptide-33), Macrocystis Pyrifera (Kelp) Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Acetyl Tetrapeptide- 15, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Decapeptide-4 (Reproage peptide), Tetrapeptide-2 (Uplevity), Palmitoyl Pentapeptide-4, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Ferulic Acid, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex), Allantoin, Clearthix S (Algin and Cellulose Gum), Sodium Phytate. In some embodiments, the customized skin care regimen optionally comprises parfum.

[0165] In some embodiments, the customized skin care regimen comprises the composition of Table 30. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Acetyl Hexapeptide-8 (Argeriline), Acetyl Hexapeptide- 30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Glycerin, Acetyl Octapeptide-3 (SNAP-8), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Palmitoyl Tripeptide-5, Decapeptide- 12, Palmitoyl Tripep tide-38, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Nonapeptide- 1, IPTS / 200163675.3 A lAttorney Docket No.: VIB-030WOPalmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Acetyl Tetrapeptide- 5 (Eyeseryl), Tripeptide-29, Hexapeptide-11, Tripeptide-33 (DAP-Tripeptide-33), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Tetrapeptide-2 (Uplevity), Acetyl Hexapeptide- 38 (Adifyline), Butylene Glycol, Dimethyl Isosorbide, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Copper Tripeptide- 1 (GHK-Cu), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide- 5 Diaminobutyroyl Hydroxy threonine and Palmitoyl Dipeptide- 5 Diaminohydroxybutyrate), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen comprises Water (aqua), Acetyl Hexapeptide-8 (Argeriline), Acetyl Hexapeptide- 30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Glycerin, Acetyl Octapeptide-3 (SNAP-8), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Palmitoyl Tripeptide-5, Decapeptide- 12, Palmitoyl Tripeptide-38, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Nonapeptide- 1, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Acetyl Tetrapeptide- 5 (Eyeseryl), Tripeptide-29, Hexapeptide-11, Tripeptide-33 (DAP-Tripeptide-33), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Tetrapeptide-2 (Uplevity), Acetyl Hexapeptide- 38 (Adifyline), Butylene Glycol, Dimethyl Isosorbide, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Copper Tripeptide- 1 (GHK-Cu), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide- 5 Diaminobutyroyl Hydroxy threonine and Palmitoyl Dipeptide- 5 Diaminohydroxybutyrate), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3 / NP). In some embodiments, the customized skin care regimen optionally comprises parfum.IPTS / 200163675.3 f.'fAttorney Docket No.: VIB-030WO

[0166] In some embodiments, the customized skin care regimen comprises the composition of Table 31. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Decorinyl (Tripeptide- 1 and Palmitoyl Tripeptide- 1 and Palmitoyl Tetrapeptide-7 and Acetyl Dipeptide- 1 Cetyl Ester, Tripeptide- 10 Citrulline), Hexapeptide-49 (Delisens Solution), Acetyl Hexapeptide-30 (Inyline), Hexapeptide- 11, Acetyl Octapeptide-3 (SNAP-8), Nonapeptide- 1, Palmitoyl Tripeptide-5, Dipeptide-2, Acetyl Tetrapeptide- 15, Tetrapeptide-2 (Uplevity), PEG- 16 Macadamia Glycerides, Hydroxypropyl Tetrahydropyrantriol (Proxylane), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide-29, Palmitoyl Pentapeptide-4, Tripeptide-33 (DAP- Tripep tide-33), Sorbitol (Sorbitol 70), Glycerin, Decapeptide-4 (Reproage), Butylene Glycol, Dimethyl Isosorbide, Magnesium Ascorbyl Phosphate, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Copper Tripeptide- 1 (GHK-Cu), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Caffeine, Ceramide NP (Ceramide 3 / NP), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate. In some embodiments, the customized skin care regimen comprises Water (aqua), Decorinyl (Tripeptide- 1 and Palmitoyl Tripeptide- 1 and Palmitoyl Tetrapeptide-7 and Acetyl Dipeptide- 1 Cetyl Ester, Tripeptide- 10 Citrulline), Hexapeptide-49 (Delisens Solution), Acetyl Hexapeptide-30 (Inyline), Hexapeptide- 11, Acetyl Octapeptide-3 (SNAP- 8), Nonapeptide- 1, Palmitoyl Tripeptide-5, Dipeptide-2, Acetyl Tetrapeptide- 15, Tetrapeptide-2 (Uplevity), PEG- 16 Macadamia Glycerides, Hydroxypropyl Tetrahydropyrantriol (Proxylane), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide-29, Palmitoyl Pentapeptide-4, Tripeptide-33 (DAP-Tripeptide-33), Sorbitol (Sorbitol 70), Glycerin, Decapeptide-4 (Reproage), Butylene Glycol, Dimethyl Isosorbide, Magnesium Ascorbyl Phosphate, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D- Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Copper Tripeptide- 1 (GHK-Cu), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Caffeine, Ceramide NP (Ceramide 3 / NP), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate. In some embodiments, the customized skin care regimen optionally comprises parfum.IPTS / 200163675.3 AOAttorney Docket No.: VIB-030WO

[0167] In some embodiments, the customized skin care regimen comprises the composition of Table 32. In some embodiments, the customized skin care regimen comprises one or more ingredients selected from the group consisting of: Water (aqua), Inyline (Tripeptide- 1 and Palmitoyl Tripeptide- 1 and Palmitoyl Tetrapeptide-7 and Acetyl Dipeptide- 1 Cetyl Ester, Nonapeptide- 1, Acetyl Hexapeptide-30), Hexapeptide-49 (Delisens), Tripeptide-10 Citrulline (Decorinyl), Acetyl Octapeptide-3 (SNAP-8), Hexapeptide- 11, Glycerin, Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, PEG- 16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Sorbitol (Sorbitol 70), Oligopeptide- 10, Butylene Glycol, Dimethyl Isosorbide, Magnesium Ascorbyl Phosphate, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D- Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Tripeptide-33 (DAP- Tripep tide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Clearthix S (Algin and Cellulose Gum), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Caffeine, Ceramide NP (Ceramide 3 / NP), Ferulic Acid, Hydroxy ethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate. In some embodiments, the customized skin care regimen comprises Water (aqua), Inyline (Tripeptide- 1 and Palmitoyl Tripeptide- 1 and Palmitoyl Tetrapeptide-7 and Acetyl Dipeptide- 1 Cetyl Ester, Nonapeptide- 1, Acetyl Hexapeptide-30), Hexapeptide-49 (Delisens), Tripeptide-10 Citrulline (Decorinyl), Acetyl Octapeptide-3 (SNAP-8), Hexapeptide- 11, Glycerin, Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, PEG- 16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Sorbitol (Sorbitol 70), Oligopeptide- 10, Butylene Glycol, Dimethyl Isosorbide, Magnesium Ascorbyl Phosphate, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Clearthix S (Algin and Cellulose Gum), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Caffeine, IPTS / 200163675.3Attorney Docket No.: VIB-030WOCeramide NP (Ceramide 3 / NP), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate. In some embodiments, the customized skin care regimen optionally comprises parfum.

[0168] In some embodiments, the composition and method described herein comprise a plurality of elements for each skin activity category. In some embodiments, the plurality of elements for each skin activity category comprises one or more peptides, one or more prebiotics, one or more probiotics, and / or one or more vitamins.

[0169] In some embodiments, the plurality of elements for each skin activity category comprises one or more peptides.

[0170] In some embodiments, the one or more peptides for the anti-aging and wrinkle reduction category comprise one or more of palmitoyl pentapeptide-4 (Matrixyl), acetyl dipeptide- 1 cetyl ester (Idealift), acetyl hexapeptide-8 (Argireline), acetyl hexapeptide- 30 (InylineO-Peptide), acetyl hexapeptide- 51 amide (Juveleven), Argirelox (Pentapeptide 18+ Argireline), SNAP 8-acetyl octapeptide- 3, Pal-Tripeptide 5, GHK Cu, Reproage™, Synake, palmitoyl pentapeptide 38 or Tripeptide-29.

[0171] In some embodiments, the one or more peptides for the skin firming and elasticity category comprise one or more of palmitoyl hexapeptide- 12 (Biopeptide EL), palmitoyl oligopeptide (Bio-bustyl), myristoyl pentapeptide- 8 (SymPeptide 222), acetyl heptapeptide 4 (Fensebiome), triptide- 10 citrulline (Decorinyl), hexapeptide- 10 (Serilesine), acetyl tetrapeptide- 11 (Syniorage), acetyl hexapeptide- 38 (Adifyline), hexapeptide- 11 (Peptide Vinci 2), acetyl dipeptide- 13 diphenylglycine (Relistase), Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate), or acetyl tetrapeptide- 2 (Uplevity).

[0172] In some embodiments, the one or more peptides for the hydration and skin barrier repair category comprise one or more of Decapeptide-4, acetyl hexapeptide-37 (Diffuporine), Oligopeptide-24 (EGF-like peptide), FSS Ceramide 3, sodium pea, or APT-GPF.

[0173] In some embodiments, the one or more peptides for the anti-inflammatory and soothing category comprise one or more of acetyl hexapeptide-49 (Delisens), palmitoyl tetrapeptide-7, acetyl tetrapeptide- 15 (Skinasensyl), polyquaternium-51, allantoin, hesperdine methyl chaicone, acetyl tetrapeptide-40 (TELANGYN), acetyl dipeptide-3 aminohexanoate (Bodyfensine), Oligopeptide- 10, or Acetyl Tetrapeptide-2 (Syn-UP).

[0174] In some embodiments, the one or more peptides for the brightening and pigmentation category comprise one or more of Hexapeptide-2, Nonapeptide- 1 (Melanostatine), Decapeptide 12, Oligopeptide-34, or Oligopeptide-51.IPTS / 200163675.3Attorney Docket No.: VIB-030WO

[0175] In some embodiments, the one or more peptides for the lymphatic drainage category comprise eyeseryl-acetyl tetrapeptide-5.

[0176] In some embodiments, the one or more peptides for the UV / Oxidative Damage / DNA / Cell damage category comprise one or more of DAP tripeptide 33, Pepha- tight, ferulic acid, acetyl tetrapeptide-22 (Thermostressine), acetyl heptapeptide- 1, or tripeptide- 9 citrulline (dGlyage).

[0177] In some embodiments, the customized skin regimen further comprises one or more prebiotic and / or probiotic.

[0178] In some embodiments, the one or more prebiotic and probiotic comprise one or more of Pepha active, beta glucan, Bacillus extract, sea kelp extract, or alpaflor sebum.

[0179] In some embodiments, the customized skin regimen further comprises one or more vitamins.

[0180] In some embodiments, the one or more vitamins comprises one or more of D- Panthenol, magnesium ascorbyl phosphate, tocopherols, or niacinamide.

[0181] The supplement or topical can be formulated at an effective amount in the skin care regimen composition. Exemplary effective concentrations for active elements, such as any active element disclosed in any of Tables 6-7 can be can be 0.1 %- 10% volume by volume (vol / vol), 0.1-10% wt / vol, or 0.1-10% wt / wt. For example, the concentration can be about 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, or 10% vol / vol, wt / vol, or wt / wt.

[0182] Exemplary effective amounts of active elements, such as any active element disclosed in any of Tables 6-7, can also be between about 0.5-1500 mg / day. For example, 0.5 mg / day, 1 mg / day, 2 mg / day, 3 mg / day, 4 mg / day, 5 mg / day, 6 mg / day, 7 mg / day, 8 mg / day, 9 mg / day, 10 mg / day, 20 mg / day, 25 mg / day, 30 mg / day, 35 mg / day, 40 mg / day, 45 mg / day, 50 mg / day, 55 mg / day, 60 mg / day, 65 mg / day, 70 mg / day, 75 mg / day, 80 mg / day, 85 mg / day, 90 mg / day, 95 mg / day, 100 mg / day, 110 mg / day, 120 mg / day, 130 mg / day, 140 mg / day, 150 mg / day, 160 mg / day, 170 mg / day, 180 mg / day, 190 mg / day, 200 mg / day, 250 mg / day, 250 mg / day, 275 mg / day, 300 mg / day, 325 mg / day, 350 mg / day, 375 mg / day, 400 mg / day, 425 mg / day, 450 mg / day, 475 mg / day, 500 mg / day, 525 mg / day, 550 mg / day, 575 mg / day, 600 mg / day, 625 mg / day, 650 mg / day, 675 mg / day, 700 mg / day, 725 mg / day, 750 mg / day, 775 mg / day, 800 mg / day, 825 mg / day, 850 mg / day, 875 mg / day, 900 mg / day, 925 mg / day, 950 mg / day, 975 mg / day, 1000 mg / day, 1025 mg / day, 1050 mg / day, 1075 mg / day, 1100 mg / day, 1125 mg / day, 1150 mg / day, 1175 mg / day, 1200 mg / day, 1225 mg / day, 1250 mg / day, 1275 mg / day, 1300 mg / day, 1325 mg / day, 1350 mg / day, 1375 mg / day, 1400 mg / day, 1425 mg / day, 1450 mg / day, 1475 mg / day, 1500 mg / day, or between about 0.5-1 IPTS / 200163675.3 f-f.Attorney Docket No.: VIB-030WO mg / day, 1-5 mg / day, 5-10 mg / day, 10-15 mg / day, 15-20 mg / day, 25-30 mg / day, 35-40 mg / day, 45-50 mg / day, 55-60 mg / day, 65-70 mg / day, 60-75 mg / day 75-80 mg / day, 85-90 mg / day, 95-100 mg / day, 100-105 mg / day, 105-100 mg / day, 110-115 mg / day, 115-120 mg / day, 125-130 mg / day, 135-140 mg / day, 145-150 mg / day, 155-160 mg / day, 165-170, 170- 180 mg / day, 175-80 mg / day, 185-90 mg / day, 195-200 mg / day, 200-205 mg / day, 205-210 mg / day, 210-215 mg / day, 215-220 mg / day, 225-230 mg / day, 235-240 mg / day, 245-250 mg / day, 255-260 mg / day, 265-270 mg / day, 275-280 mg / day, 285-290 mg / day, 295-300 mg / day, 300-305 mg / day, 305-310 mg / day, 310-315 mg / day, 315-320 mg / day, 325-330 mg / day, 335-340 mg / day, 345-350 mg / day, 355-360 mg / day, 365-370 mg / day, 375-380 mg / day, 385-390 mg / day, 395-400 mg / day, 400-405 mg / day, 405-410 mg / day, 410-415 mg / day, 415-420 mg / day, 425-430 mg / day, 435-440 mg / day, 445-450 mg / day, 455-460 mg / day, 465-470 mg / day, 475-480 mg / day, 485-490 mg / day, 495-500 mg / day, 500-505 mg / day, 505-510 mg / day, 510-515 mg / day, 515-520 mg / day, 525-530 mg / day, 535-540 mg / day, 545-550 mg / day, 555-560 mg / day, 565-570 mg / day, 575-580 mg / day, 585-590 mg / day, 595-600 mg / day, 600-605 mg / day, 605-610 mg / day, 610-615 mg / day, 615-620 mg / day, 625-630 mg / day, 635-640 mg / day, 645-650 mg / day, 655-660 mg / day, 665-670 mg / day, 675-680 mg / day, 685-690 mg / day, 695-700 mg / day, 700-750 mg / day, 750-800 mg / day, 85-900 mg / day, 950-1000 mg / day, 1000-1100 mg / day, 1100-1200 mg / day, 1200- 1300 mg / day, 1300-1400 mg / day, or 1400-1500 mg / day, or any amount in between.Exemplary effective amounts can also be between about 1-400 mcg / day, such as 1 mcg / day, 2 mcg / day, 2.4 mcg / day, 3 mcg / day, 4 mcg / day, 5 mcg / day, 6 mcg / day, 7 mcg / day, 8 mcg / day, 9 mcg / day, 10 mcg / day, 20 mcg / day, 25 mcg / day, 30 mcg / day, 35 mcg / day, 40 mcg / day, 45 mcg / day, 50 mcg / day, 55 mcg / day, 60 mcg / day, 65 mcg / day, 70 mcg / day, 75 mcg / day, 80 mcg / day, 85 mcg / day, 90 mcg / day, 95 mcg / day, 100 mcg / day, 110 mcg / day, 120 mcg / day, 130 mcg / day, 140 mcg / day, 150 mcg / day, 160 mcg / day, 170 mcg / day, 180 mcg / day, 190 mcg / day, 200 mcg / day, 250 mcg / day, 300 mcg / day, 350 mcg / day, or 400 mcg / day or any amount in between.

[0183] In some embodiments, the composition described herein comprises a concentration of water (aqua) between about 5%-95% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of water (aqua) is between about 5%- 10%, between about 10%- 15%, between about 15%-20%, 20%-25%, between about 25%-30%, between about 30%-35%, between about 35%-40%, between about 40%-45%, between about 45%-50%, between about 50%-55%, between about 55%-60%, between about 60%-65%, between about 65%-70%, between about 70%-75%, between about 75%-80, between about 80%-85%, IPTS / 200163675.3Attorney Docket No.: VIB-030WO between about 85%-90%, or between about 90%-95% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of water (aqua) is 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95% vol / vol, wt / vol, or wt / wt.

[0184] In some embodiments, the composition described herein comprises a concentration of Palmitoyl Pentapeptide-4 (Matrixyl) between about 0.5-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl Pentapeptide-4 (Matrixyl) is between about 0.5%-1.0%, between about 1%-1.5%, between about 1.5%-2.0%, between about 2.0%-2.5%, between about 2.5%-3.0%, between about 3.0%-3.5%, between about 3.5%-4.0%, between about 4.0%-4.5%, or between about 4.5%-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl Pentapeptide-4 (Matrixyl) is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%,1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%,3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%,4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0185] In some embodiments, the composition described herein comprises a concentration of Palmitoyl Pentapeptide-4 (Matrixyl) between about 5.1% and 10.0%. In some embodiments, the concentration of Palmitoyl Pentapeptide-4 (Matrixyl) is between about 5.1%-5.5%, between about 5.5%-6.0%, between about 6.0%-6.5%, between about 6.5%-7.0%, between about 7.0%-7.5%, between about 7.5%-8.0%, between about 8.0%- 8.5%, between about 8.5%-9.0%, between about 9.0%-9.5%, or between about 9.5%-10.0% vol / vol, wt / vol, or wt / wt. In some embodiments, the concentration of Palmitoyl Pentapeptide- 4 (Matrixyl) is 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6.0%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8.0%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, or 10.0% vol / vol, wt / vol, or wt / wt.

[0186] In some embodiments, the composition described herein comprises a concentration of Acetyl Dipeptide- 1 Cetyl Ester (Idealift) between about 3.0-4.0%. In some embodiments the concentration of Acetyl Dipeptide- 1 Cetyl Ester (Idealift) is between about 3.0%-3.5%, between about 3.5%-4.0 %, between about 4.0%-4.5%, or between about 4.5%- 5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Dipeptide- 1 Cetyl Ester (Idealift) is 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, or 4.0% vol / vol, wt / vol, or wt / wt.

[0187] In some embodiments, the composition described herein comprises a concentration of Acetyl Hexapeptide-8 (Argireline) between about 3.0-6.0% vol / vol, wt / vol, IPTS / 200163675.3 QAttorney Docket No.: VIB-030WO or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-8 (Argireline) is between about 3.0%-3.5%, between about 3.5%-4.0%, between about 4.0%-4.5%, between about 4.5%-5.0%, between about 5.0%-5.5%, or 5.5%-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-8 (Argireline) is 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.46%, 3.5%, 3.56%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.03% 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, or 6.0% vol / vol, wt / vol, or wt / wt.

[0188] In some embodiments, the composition described herein comprises a concentration of Acetyl Hexapeptide-8 (Argireline) between about 6.1% and 10.0%. In some embodiments, the concentration of Acetyl Hexapeptide-8 (Argireline) is between about 6.1%- 6.5%, between about 6.5%-7.0%, between about 7.0%-7.5%, between about 7.5%-8.0%, between about 8.0%-8.5%, between about 8.5%-9.0%, between about 9.0%-9.5%, or between about 9.5%-10.0%. In some embodiments, the concentration of Acetyl Hexapeptide-8 (Argireline) is 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, 7.4%, 7.43%, 7.49%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8.0%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, or 10.0% vol / vol, wt / vol, or wt / wt.

[0189] In some embodiments, the composition described herein comprises a concentration of Acetyl Hexapeptide- 30 (InylineO-Peptide) between about 3.0-4.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-30 (InylineO-Peptide) is between about 3.0%-3.5%, between about or 3.5%-4.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-30 (InylineO-Peptide) is 3.0%, 3.1%, 3.2%, 3.28%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 3.95%, 3.958%, or 4.0% vol / vol, wt / vol, or wt / wt.

[0190] In some embodiments, the composition described herein comprises a concentration of Acetyl Hexapeptide-30 (InylineO-Peptide) between about 4.0-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-30 (InylineO-Peptide) is between about 4.0%-4.5%, or 4.5%-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-30 (InylineO-Peptide) is 4.0%, 4.01%, 4.03%, 4.09%, 4.1%, 4.12%, 4.17%, 4.2%, 4.3%, 4.32%, 4.34%, 4.35%, 4.37%, 4.4%, 4.45%, 4.5%, 4.56%, 4.6%, 4.7%, 4.71%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0191] In some embodiments, the composition described herein comprises a concentration of Acetyl Hexapeptide- 51 Amide (Juveleven) between about 0.5-1.5% vol / vol, IPTS / 200163675.3 Z.QAttorney Docket No.: VIB-030WO wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-51 Amide (Juveleven) is between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%- 0.9%, between about 0.8%- 1.0%, between about 0.9%-l.1%, between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%-1.4% or between about 1.3%- 1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-51 Amide (Juveleven) is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.48%, or 1.5% vol / vol, wt / vol, or wt / wt.

[0192] In some embodiments, the composition described herein comprises a concentration of Acetyl Hexapeptide-51 Amide (Juveleven) between about 1.5-2.2% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-51 Amide (Juveleven) is between about 1.5%-1.7%, between about 1.6%- 1.8%, between about 1.7%- 1.9%, between about 1.8%-2.0%, between about 1.9%-2.1%, or between about 2.0%-2.2% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-51 Amide (Juveleven) is 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.12%, 2.14%, or 2.2% vol / vol, wt / vol, or wt / wt.

[0193] In some embodiments, the composition described herein comprises a concentration of Argirelox (Pentapeptide 18+Argireline) between about 3.0-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Argirelox (Pentapeptide 18+Argireline) is between about 3.0%-3.5%, between about 3.5%-4.0%, between about 4.0%-4.5%, between about 4.5%-5.0%, between about 5.0%-5.5%, or 5.5%-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Argirelox (Pentapeptide 18+Argireline) is 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.73%, 4.8%, 4.9%, 5.0%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 5.937%, or 6.0% vol / vol, wt / vol, or wt / wt.

[0194] In some embodiments, the composition described herein comprises a concentration of Argirelox (Pentapeptide 18+Argireline) between about 6.1% and 10.0%. In some embodiments, the concentration of Argirelox (Pentapeptide 18+Argireline) is between about 6. l%-6.5%, between about 6.5%-7.0%, between about 7.0%-7.5%, between about 7.5%-8.0%, between about 8.0%-8.5%, between about 8.5%-9.0%, between about 9.0%- 9.5%, or between about 9.5%-10.0%. In some embodiments, the concentration of Argirelox (Pentapeptide 18+Argireline) is 6.1%, 6.2%, 6.26%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.85%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, 7.4%, 7.41%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8.0%, 8.01%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4%, 9.42%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, or 10.0% vol / vol, wt / vol, or wt / wt.IPTS / 200163675.3 7QAttorney Docket No.: VIB-030WO

[0195] In some embodiments, the composition described herein comprises a concentration of SNAP 8-acetyl octapeptide-3 between about 3.0-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of SNAP 8-acetyl octapeptide-3 is between about 1.0%-1.5%, between about 1.5%-2.0%, between about 2.0%-2.5%, between about 2.5%-3.0%, between about 3.0%-3.5%, between about 3.5%-4.0%, between about 4.0%- 4.5%, between about 4.5%-5.0%, between about 5.0%-5.5%, or 5.5%-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of SNAP 8-acetyl octapeptide-3 is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.64%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.22%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 2.97%, 3.0%, 3.1%, 3.16%, 3.18%, 3.2%, 3.23%, 3.3%, 3.4%, 3.5%, 3.6%, 3.65%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, or 6.0% vol / vol, wt / vol, or wt / wt.

[0196] In some embodiments, the composition described herein comprises a concentration of SNAP 8-acetyl octapeptide-3 between about 6.1% and 10.0%. In some embodiments, the concentration of SNAP 8-acetyl octapeptide-3 is between about 6.1%- 6.5%, between about 6.5%-7.0%, between about 7.0%-7.5%, between about 7.5%-8.0%, between about 8.0%-8.5%, between about 8.5%-9.0%, between about 9.0%-9.5%, or between about 9.5%-10.0%. In some embodiments, the concentration of SNAP 8-acetyl octapeptide-3 is 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8.0%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, or 10.0% vol / vol, wt / vol, or wt / wt.

[0197] In some embodiments, the composition described herein comprises a concentration of Pal-Tripeptide 5 between about 1.0-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Pal-Tripeptide 5 is between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%-1.4%, between about 1.3%- 1.5%, between about 1.5%-1.7%, between about 1.6%-1.8%, between about 1.7%-1.9%, or between about 1.8%- 2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Pal-Tripeptide 5 is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0% vol / vol, wt / vol, or wt / wt.

[0198] In some embodiments, the composition described herein comprises a concentration of Pal-Tripeptide 5 between about 2.1-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Pal-Tripeptide 5 is between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.5%, between about 2.4%-2.6%, between about IPTS / 200163675.3 71Attorney Docket No.: VIB-030WG2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%- 3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Pal-Tripeptide 5 is 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0199] In some embodiments, the composition described herein comprises a concentration of GHK Cu between about 0.5-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of GHK Cu is between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, between about 0.8%-1.0%, between about 0.9%- 1.1%, between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%- 1.5%, between about 1.4%-1.6%, between about 1.5%- 1.7%, between about 1.6%-1.8%, between about 1.7%-1.9%, or between about 1.8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of GHK Cu is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0% vol / vol, wt / vol, or wt / wt.

[0200] In some embodiments, the composition described herein comprises a concentration of GHK Cu between about 2.1-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of GHK Cu is between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.4%, between about 2.4%-2.5%, between about 2.6%- 2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of GHK Cu is 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0201] In some embodiments, the composition described herein comprises a concentration of Reproage is between about 0.1-1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Reproage is between about 0.1%-0.3%, between about 0.2%-0.4%, between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%- 0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, or between about 0.8%-1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Reproage is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0202] In some embodiments, the composition described herein comprises a concentration of Reproage is between about 1.1-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Reproage is between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%- 1.5%, between about 1.4%-1.6%, between about 1.5%- 1.7%, between about 1.6%- 1.8%, between about 1.7%-1.9%, or between about 1.8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Reproage is 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0% vol / vol, wt / vol, or wt / wt.IPTS / 200163675.3 77Attorney Docket No.: VIB-030WO

[0203] In some embodiments, the composition described herein comprises a concentration of Synake between about 1.0-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Synake is between about 1.0%-1.2%, between about 1.1%- 1.3%, between about 1.2%-1.4%, between about 1.3%-1.5%, between about 1.5%-1.7%, between about 1.6%-1.8%, between about 1.7%-1.9%, or between about 1.8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Synake is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0% vol / vol, wt / vol, or wt / wt.

[0204] In some embodiments, the composition described herein comprises a concentration of Synake between about 2.1-4.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Synake is between about 2. l%-2.3%, between about 2.2%- 2.4%, between about 2.3%-2.4%, between about 2.4%-2.5%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0%, between about 2.9%-3.1%, between about 3.0%-3.2%, between about 3.1%-3.3%, between about 3.2%-3.4%, between about 3.3%-3.5%, between about 3.4%-3.6%, between about 3.5%-3.7%, between about 3.6%- 3.8%, between about 3.7%-3.9%, or between about 3.8%-4.0%. In some embodiments the concentration of Synake is 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, or 4.0% vol / vol, wt / vol, or wt / wt.

[0205] In some embodiments, the composition described herein comprises a concentration of Palmitoyl Tripeptide 38 between about 2.0-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl Tripeptide 38 is between about 2.0%- 2.2%, between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl Tripeptide 38 is 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0206] In some embodiments, the composition described herein comprises a concentration of Palmitoyl Tripeptide 38 between about 3.1-4.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl Tripeptide 38 is between about 3.1%- 3.3%, between about 3.2%-3.4%, between about 3.3%-3.5%, between about 3.4%-3.6%, between about 3.5%-3.7%, between about 3.6%-3.8%, between about 3.7%-3.9%, or between about 3.8%-4.0%. In some embodiments the concentration of Palmitoyl Tripeptide 38 is 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, or 4.0% vol / vol, wt / vol, or wt / wt.

[0207] In some embodiments, the composition described herein comprises a concentration of Palmitoyl Hexapeptide- 12 (Biopeptide EL) between about 3.0-6.0% vol / vol, IPTS / 200163675.3 70Attorney Docket No.: VIB-030WO wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl Hexapeptide- 12 (Biopeptide EL) is between about 3.0%-3.5%, between about 3.5%-4.0%, between about 4.0%-4.5%, between about 4.5%-5.0%, between about 5.0%-5.5%, or 5.5%-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl Hexapeptide- 12 (Biopeptide EL) is 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, or 6.0% vol / vol, wt / vol, or wt / wt.

[0208] In some embodiments, the composition described herein comprises a concentration of Palmitoyl Hexapeptide- 12 (Biopeptide EL) between about 6.1% and 10.0%. In some embodiments, the concentration of Palmitoyl Hexapeptide- 12 (Biopeptide EL) is between about 6. l%-6.5%, between about 6.5%-7.0%, between about 7.0%-7.5%, between about 7.5%-8.0%, between about 8.0%-8.5%, between about 8.5%-9.0%, between about 9.0%-9.5%, or between about 9.5%-10.0%. In some embodiments, the concentration of Palmitoyl Hexapeptide- 12 (Biopeptide EL) is 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8.0%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, or 10.0% vol / vol, wt / vol, or wt / wt.

[0209] In some embodiments, the composition described herein comprises a concentration of Palmitoyl Oligopeptide (Bio-bustyl) between about 0.2%-0.5%. In some embodiments, the concentration of Palmitoyl Oligopeptide (Bio-bustyl) is between about 0.200%-0.225%, between about 0.225%-0.250%, between about 0.250%-0.275%, between about 0.275%-0.300%, between about 0.300%-0.325%, between about 0.325%-0.350%, between about 0.350%-0.375%, between about 0.375%-0.400%, between about 0.400%- 0.425%, between about 0.425%-0.450%, between about 0.450%-0.475%, or between about 0.475%-0.500%. In some embodiments, the concentration of Palmitoyl Oligopeptide (Bio- bustyl) is 0.200%, 0.225%, 0.250%, 0.275%, 0.300%, 0.325%, 0.350%, 0.375%, 0.400%, 0.425%, 0.450%, 0.475%, or 0.500% vol / vol, wt / vol, or wt / wt.

[0210] In some embodiments, the composition described herein comprises a concentration of Palmitoyl Oligopeptide (Bio-bustyl) between about 0.600%-1.000%. In some embodiments, the concentration of Palmitoyl Oligopeptide (Bio-bustyl) is between about 0.600%-0.625%, between about 0.625%-0.650%, between about 0.650%-0.675%, between about 0.675%-0.700%, between about 0.700%-0.725%, between about 0.725%- 0.750%, between about 0.750%-0.775%, between about 0.775%-0.800%, between about 0.800%-0.825%, between about 0.825%-0.850%, between about 0.850%-0.875%, between IPTS / 200163675.3 74Attorney Docket No.: VIB-030WO about 0.875%-0.900%, between about 0.900%-0.925%, between about 0.925%-0.950%, between about 0.950%-0.975%, or between about 0.975%-1.000%. In some embodiments, the concentration of Palmitoyl Oligopeptide (Bio-bustyl) is 0.600%, 0.625%, 0.650%, 0.675%, 0.700%, 0.725%, 0.750%, 0.775%, 0.800%, 0.825%, 0.850%, 0.875%, 0.900%, 0.925%, 0.950%, 0.975%, or 1.000% vol / vol, wt / vol, or wt / wt.

[0211] In some embodiments, the composition described herein comprises a concentration of Myristoyl Pentapeptide- 8 (SymPeptide 222) between about 0.001%-0.006%. In some embodiments, the concentration of Myristoyl Pentapeptide- 8 (SymPeptide 222) is between about 0.0010%-0.0015%, between about 0.0015%-0.0020%, between about 0.0020%-0.0025%, between about 0.0025%-0.0030%, between about 0.0030%-0.0035%, between about 0.0035%-0.0040%, between about 0.0040%-0.0045%, between about 0.0045%-0.0050%, between about 0.0050%-0.0055%, or between about 0.0055%-0.0060%. In some embodiments, the concentration of Myristoyl Pentapeptide- 8 (SymPeptide 222) is 0.0010%, 0.0015%, 0.0020%, 0.0025%, 0.0030%, 0.0035%, 0.0040%, 0.0045%, 0.0050%, 0.0055%, or 0.0060%.

[0212] In some embodiments, the composition described herein comprises a concentration of Myristoyl Pentapeptide- 8 (SymPeptide 222) between about 0.01%-0.08%. In some embodiments, the concentration of Myristoyl Pentapeptide- 8 (SymPeptide 222) is between about 0.010%-0.015%, between about 0.015%-0.020%, between about 0.020%- 0.025%, between about 0.025%-0.030%, between about 0.030%-0.035%, between about 0.035%-0.040%, between about 0.040%-0.045%, between about 0.045%-0.050%, between about 0.050%-0.055%, between about 0.055%-0.060%, between about 0.060%-0.065%, between about 0.065%-0.070%, between about 0.070%-0.075%, between about 0.075%- 0.080%. In some embodiments, the concentration of Myristoyl Pentapeptide- 8 (SymPeptide 222) is 0.010%, 0.015%, 0.020%, 0.025%, 0.030%, 0.035%, 0.040%, 0.045%, 0.050%, 0.055%, 0.060%, 0.065%, 0.060%, 0.065%, 0.080% vol / vol, wt / vol, or wt / wt.

[0213] In some embodiments, the composition described herein comprises a concentration of Myristoyl Pentapeptide- 8 (SymPeptide 222) between about 0.04%-0.1%. In some embodiments, the concentration of Myristoyl Pentapeptide- 8 (SymPeptide 222) is between about 0.040%-0.045%, between about 0.045%-0.050%, between about 0.050%- 0.055%, between about 0.055%-0.060%, between about 0.060%-0.065%, between about 0.065%-0.070%, between about 0.070%-0.075%, between about 0.075%-0.080%, between about 0.080%-0.085%, between about 0.085%-0.090%, between about 0.090%-0.095%, or between about 0.095%-0.100%. In some embodiments, the concentration of Myristoyl IPTS / 200163675.3Attorney Docket No.: VIB-030WOPentapeptide- 8 (SymPeptide 222) is 0.040%, 0.045%, 0.050%, 0.055%, 0.060%, 0.065%, 0.070%, 0.075%, 0.080%, 0.085%, 0.090%, or 0.100% vol / vol, wt / vol, or wt / wt.

[0214] In some embodiments, the composition described herein comprises a concentration of Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan) between about 0.01%-0.06%. In some embodiments, the concentration of Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan) is between about 0.010%-0.015%, between about 0.015%-0.020%, between about 0.020%-0.025%, between about 0.025%- 0.030%, between about 0.030%-0.035%, between about 0.035%-0.040%, between about 0.040%-0.045%, between about 0.045%-0.050%, between about 0.050%-0.055%, or between about 0.055%-0.060%. In some embodiments, the concentration of Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan) is 0.010%, 0.015%, 0.020%, 0.025%, 0.030%, 0.035%, 0.040%, 0.045%, 0.050%, 0.055%, or 0.060% vol / vol, wt / vol, or wt / wt.

[0215] In some embodiments, the composition described herein comprises a concentration of Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan) between about 0.06%-0.1%. In some embodiments, the concentration of Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan) is between about 0.060%-0.065%, between about 0.065%-0.070%, between about 0.070%-0.075%, between about 0.075%- 0.080%, between about 0.080%-0.085%, between about 0.085%-0.090%, between about 0.090%-0.095%, or between about 0.095%-0.100%. In some embodiments, the concentration of Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan) is 0.060%, 0.065%, 0.070%, 0.075%, 0.080%, 0.085%, 0.090%, or 0.100% vol / vol, wt / vol, or wt / wt.

[0216] In some embodiments, the composition described herein comprises a concentration of Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan) between about 0.1 %-0.5%. In some embodiments, the concentration of Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan) is between about 0.10%-0.15%, between about 0.15%-0.20%, between about 0.20%-0.25%, between about 0.25%-0.30%, between about 0.30%-0.35%, between about 0.35%-0.40%, between about 0.40%-0.45%, or between about 0.45%-0.50%. In some embodiments, the concentration of Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan) is 0.10%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, or 0.50% vol / vol, wt / vol, or wt / wt.

[0217] In some embodiments, the composition described herein comprises a concentration of Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan) between about 0.5%- 1.0%. In some embodiments, the concentration of Pepha-tight IPTS / 200163675.3 f.Attorney Docket No.: VIB-030WO(Nannochloropsis Oculata (Algae) Extract and Pullulan) is between about 0.50%-0.55%, between about 0.55%-0.60%, between about 0.60%-0.65%, between about 0.65%-0.70%, between about 0.70%-0.75%, between about 0.75%-0.80%, between about 0.80%-0.85%, between about 0.85%-0.90%, between about 0.90%-0.95%, or between about 0.95%-1.00%. In some embodiments, the concentration of Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan) is 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, or 1.00% vol / vol, wt / vol, or wt / wt.

[0218] In some embodiments, the composition described herein comprises a concentration of Hydroxypropyl Tetrahydropyrantriol (Proxylane) between about 0.5-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hydroxypropyl Tetrahydropyrantriol (Proxylane) is between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, between about 0.8%-1.0%, between about 0.9%- 1.1%, between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%- 1.5%, between about 1.4%- 1.6%, between about 1.5%-1.7%, between about 1.6%- 1.8%, between about 1.7%- 1.9%, or between about 1.8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hydroxypropyl Tetrahydropyrantriol (Proxylane) is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0% vol / vol, wt / vol, or wt / wt.

[0219] In some embodiments, the composition described herein comprises a concentration of Acetyl Heptapeptide 4 (Fensebiome) between about 0. l%-0.5%. In some embodiments, the concentration of Acetyl Heptapeptide 4 (Fensebiome) is between about 0.10%-0.15%, between about 0.15%-0.20%, between about 0.20%-0.25%, between about 0.25%-0.30%, between about 0.30%-0.35%, between about 0.35%-0.40%, between about 0.40%-0.45%, or between about 0.45%-0.50%. In some embodiments, the concentration of Acetyl Heptapeptide 4 (Fensebiome) is 0.10%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, or 0.50% vol / vol, wt / vol, or wt / wt.

[0220] In some embodiments, the composition described herein comprises a concentration of Acetyl Heptapeptide 4 (Fensebiome) between about 0.5%- 1.0%. In some embodiments, the concentration of Acetyl Heptapeptide 4 (Fensebiome) is between about 0.50%-0.55%, between about 0.55%-0.60%, between about 0.60%-0.65%, between about 0.65%-0.70%, between about 0.70%-0.75%, between about 0.75%-0.80%, between about 0.80%-0.85%, between about 0.85%-0.90%, between about 0.90%-0.95%, or between about 0.95%-1.00%. In some embodiments, the concentration of Acetyl Heptapeptide 4IPTS / 200163675.3 77Attorney Docket No.: VIB-030WO(Fensebiome) is 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, or 1.00% vol / vol, wt / vol, or wt / wt.

[0221] In some embodiments, the composition described herein comprises a concentration of Triptide-10 Citrulline (Decorinyl) between about 1.0-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Triptide- 10 Citrulline (Decorinyl) is between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%- 1.5%, between about 1.5%-1.7%, between about 1.6%- 1.8%, between about 1.7%- 1.9%, between about 1.8%-2.0%, between about 2.0%-2.2%, between about 2.1%- 2.3%, between about 2.2%-2.4%, between about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Triptide- 10 Citrulline (Decorinyl) is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0222] In some embodiments, the composition described herein comprises a concentration of Triptide- 10 Citrulline (Decorinyl) between about 3.1-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Triptide- 10 Citrulline (Decorinyl) is between about 3.1%-3.3%, between about 3.2%-3.4%, between about 3.3%-3.5%, between about 3.4%-3.6%, between about 3.5%-3.7%, between about 3.6%-3.8%, between about 3.7%-3.9%, between about 3.8%-4.0%, between about 3.9%-4.1%, between about 4.0%- 4.2%, between about 4.1%-4.3%, between about 4.2%-4.4%, between about 4.3%-4.5%, between about 4.4%-4.6%, between about 4.5%-4.7%, between about 4.6%-4.8%, between about 4.7%-4.9%, or between about 4.8%-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Triptide-10 Citrulline (Decorinyl) is 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0223] In some embodiments, the composition described herein comprises a concentration of Hexapeptide- 10 (Serilesine) between about 1.0%-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hexapeptide- 10 (Serilesine) is between about 1.0%- 1.5%, between about 1.5%-2.0%, is between about 2.0%-2.5%, between about 2.5%-3.0%, is between about 3.0%-3.5%, between about 3.5%-4.0%, between about 4.0%- 4.5%, between about 4.5%-5.0%, between about 5.0%-5.5%, or 5.5%-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hexapeptide- 10 (Serilesine) is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, IPTS / 200163675.3 70Attorney Docket No.: VIB-030WO3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0224] In some embodiments, the composition described herein comprises a concentration of Hexapeptide- 10 (Serilesine) between about 5.1% and 10.0%. In some embodiments, the concentration of Hexapeptide- 10 (Serilesine) is between about 5.1%-5.5%, between about 5.5%-6.0%, between about 6.0%-6.5%, between about 6.5%-7.0%, between about 7.0%-7.5%, between about 7.5%-8.0%, between about 8.0%-8.5%, between about 8.5%-9.0%, between about 9.0%-9.5%, or between about 9.5%-10.0%. In some embodiments, the concentration of Hexapeptide- 10 (Serilesine) is 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6.0%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8.0%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, or 10.0% vol / vol, wt / vol, or wt / wt.

[0225] In some embodiments, the composition described herein comprises a concentration of Acetyl Tetrapeptide- 11 (Syniorage) between about 1350 ppm (parts per million)- 1500 ppm. In some embodiments the concentration of Acetyl Tetrapeptide- 11 (Syniorage) is between about 1350 ppm-1375 ppm, between about 1375 ppm-1400 ppm, between about 1400 ppm- 1425 ppm, between about 1425 ppm- 1450 ppm, between about 1450 ppm- 1475 ppm, or between about 1475 ppm- 1500 ppm. In some embodiments the concentration of Acetyl Tetrapeptide- 11 (Syniorage) is 1350 ppm, 1375 ppm, 1400 ppm, 1425 ppm, 1450 ppm, 1475 ppm, or 1500 ppm.

[0226] In some embodiments, the composition described herein comprises a concentration of Acetyl Hexapeptide- 38 (Adifyline) is between about 0.1-1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-38 (Adifyline) is between about 0.1%-0.3%, between about 0.2%-0.4%, between about 0.3%- 0.5%, between about 0.4%-0.6%, between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, or between about 0.8%- 1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-38 (Adifyline) is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.74%, 0.79%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0227] In some embodiments, the composition described herein comprises a concentration of Acetyl Hexapeptide-38 (Adifyline) is between about 1.1-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-38 (Adifyline) is between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%- 1.5%, between about 1.4%- 1.6%, between about 1.5%-1.7%, between about 1.6%- 1.8%, IPTS / 200163675.3 7QAttorney Docket No.: VIB-030WO between about 1.7%- 1.9%, or between about 1.8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide- 38 (Adifyline) is 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0% vol / vol, wt / vol, or wt / wt.

[0228] In some embodiments, the composition described herein comprises a concentration of Acetyl Hexapeptide- 38 (Adifyline) is between about 2.0-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-38 (Adifyline) is between about 2.0%-2.2%, 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.5%, between about 2.4%-2.6%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-38 (Adifyline) is 2.0%, 2.1%, 2.12%, 2.14%, 2.14%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0229] In some embodiments, the composition described herein comprises a concentration of Hexapeptide- 11 (Peptide Vinci 2) between about 0.5%-1.0%. In some embodiments, the concentration of Hexapeptide- 11 (Peptide Vinci 2) is between about 0.50%-0.55%, between about 0.55%-0.60%, 0.60%-0.65%, between about 0.65%-0.70%, between about 0.70%-0.75%, between about 0.75%-0.80%, between about 0.80%-0.85%, between about 0.85%-0.90%, between about 0.90%-0.95%, or between about 0.95%-1.00%. In some embodiments, the concentration of Hexapeptide- 11 (Peptide Vinci 2) is 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, or 1.00% vol / vol, wt / vol, or wt / wt.

[0230] In some embodiments, the composition described herein comprises a concentration of Hexapeptide- 11 (Peptide Vinci 2) is between about 1.1-1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hexapeptide- 11 (Peptide Vinci 2) is between about 1.10%- 1.15%, between about 1.15%-1.20%, between about 1.20%-1.25%, between about 1.25%-1.30%, between about 1.30%-1.35%, between about 1.35%-1.40%, between about 1.40%-1.45%, or between about 1.45%- 1.50% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hexapeptide- 11 (Peptide Vinci 2) is 1.10%, 1.15%, 1.20%, 1.25%, 1.30%, 1.35%, 1.40%, 1.45%, or 1.50% vol / vol, wt / vol, or wt / wt.

[0231] In some embodiments, the composition described herein comprises a concentration of Hexapeptide- 11 between about 1.0-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hexapeptide- 11 is between about 1.0%- 1.2%, between about 1.1%- 1.3%, between about 1.2%-1.4%, between about 1.3%- 1.5%, between about 1.5%- 1.7%, between about 1.6%- 1.8%, between about 1.7%-1.9%, between about 1.8%- 2.0%, between about 2.0%-2.2%, between about 2. l%-2.3%, between about 2.2%-2.4%, IPTS / 200163675.3 onAttorney Docket No.: VIB-030WO between about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hexapeptide- 11 is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0232] In some embodiments, the composition described herein comprises a concentration of Acetyl Dipeptide- 13 Diphenylglycine (Relistase) between about 1.0-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Dipeptide- 13 Diphenylglycine (Relistase) is between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%-1.5%, between about 1.5%- 1.7%, between about 1.6%-1.8%, between about 1.7%-1.9%, or between about 1.8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Dipeptide- 13 Diphenylglycine (Relistase) is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0%. In some embodiments, the concentration of Acetyl Dipeptide- 13 Diphenylglycine (Relistase) is 1.0% vol / vol, wt / vol, or wt / wt.

[0233] In some embodiments, the composition described herein comprises a concentration of Acetyl Dipeptide- 13 Diphenylglycine (Relistase) between about 2.1-4.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Dipeptide- 13 Diphenylglycine (Relistase) is between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.4%, between about 2.4%-2.5%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0%, between about 2.9%-3.1%, between about 3.0%-3.2%, between about 3.1%-3.3%, between about 3.2%-3.4%, between about 3.3%- 3.5%, between about 3.4%-3.6%, between about 3.5%-3.7%, between about 3.6%-3.8%, between about 3.7%-3.9%, or between about 3.8%-4.0%. In some embodiments the concentration of Acetyl Dipeptide-13 Diphenylglycine (Relistase) is 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, or 4.0% vol / vol, wt / vol, or wt / wt.

[0234] In some embodiments, the composition described herein comprises a concentration of Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate) between about 0.1%- 0.5%. In some embodiments, the concentration of Syn-TacksSyn-Tacks (palmitoyl dipeptide- 5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate) is between about 0.10%-0.15%, between about 0.15%-0.20%, between about 0.20%-0.25%, between about 0.25%-0.30%, between about 0.30%-0.35%, between about 0.35%-0.40%, IPTS / 200163675.3 01Attorney Docket No.: VIB-030WG between about 0.40%-0.45%, or between about 0.45%-0.50%. In some embodiments, the concentration of Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate) is 0.10%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, or 0.50% vol / vol, wt / vol, or wt / wt.

[0235] In some embodiments, the composition described herein comprises a concentration of Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate) between about 0.6%- 1.0%. In some embodiments, the concentration of Syn-TacksSyn-Tacks (palmitoyl dipeptide- 5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate) is between about 0.60%-0.65%, between about 0.65%-0.70%, between about 0.70%-0.75%, between about 0.75%-0.80%, between about 0.80%-0.85%, between about 0.85%-0.90%, between about 0.90%-0.95%, or between about 0.95%-1.00%. In some embodiments, the concentration of Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate) is 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, or 1.00% vol / vol, wt / vol, or wt / wt.

[0236] In some embodiments, the composition described herein comprises a concentration of Acetyl Tetrapeptide-2 (Uplevity) is between about 0.1- 1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Tetrapeptide-2 (Uplevity) is between about 0.1%-0.3%, between about 0.2%-0.4%, between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, or between about 0.8%- 1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Tetrapeptide-2 (Uplevity) is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0237] In some embodiments, the composition described herein comprises a concentration of Acetyl Tetrapeptide-2 (Uplevity) is between about 1.1-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Tetrapeptide-2 (Uplevity) is between about 1.1%-1.3%, between about 1.2%-1.4%, between about 1.3%- 1.5%, between about 1.4%- 1.6%, between about 1.5%-1.7%, between about 1.6%- 1.8%, between about 1.7%- 1.9%, or between about 1.8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Tetrapeptide-2 (Uplevity) is 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0% vol / vol, wt / vol, or wt / wt.

[0238] In some embodiments, the composition described herein comprises a concentration of Copper Tripeptide- 1 (GHK-Cu) is between about 0.1- 1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Copper Tripeptide- 1 (GHK-Cu) is IPTS / 200163675.3 0Attorney Docket No.: VIB-030WO between about 0.1%-0.3%, between about 0.2%-0.4%, between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, or between about 0.8%- 1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Copper Tripeptide-1 (GHK-Cu) is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0239] In some embodiments, the composition described herein comprises a concentration of Decapeptide-4 (Reproage) is between about 0.1-1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Decapeptide-4 (Reproage) is between about 0.1%-0.3%, between about 0.2%-0.4%, between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%- 0.9%, or between about 0.8%- 1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Decapeptide-4 (Reproage) is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0240] In some embodiments, the composition described herein comprises a concentration of Decapeptide-4 between about 1.0-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Decapeptide-4 is between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%-1.4%, between about 1.3%- 1.5%, between about 1.5%- 1.7%, between about 1.6%- 1.8%, between about 1.7%-1.9%, between about 1.8%- 2.0%, between about 2.0%-2.2%, between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Decapeptide-4 is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0241] In some embodiments, the composition described herein comprises a concentration of Decapeptide-4 between about 3.1-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Decapeptide-4 is between about 3.1%-3.3%, between about 3.2%-3.4%, between about 3.3%-3.5%, between about 3.4%-3.6%, between about 3.5%-3.7%, between about 3.6%-3.8%, between about 3.7%-3.9%, between about 3.8%- 4.0%, between about 3.9%-4.1%, between about 4.0%-4.2%, between about 4.1%-4.3%, between about 4.2%-4.4%, between about 4.3%-4.5%, between about 4.4%-4.6%, between about 4.5%-4.7%, between about 4.6%-4.8%, between about 4.7%-4.9%, or between about 4.8%-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration ofIPTS / 200163675.3 83Attorney Docket No.: VIB-030WODecapeptide-4 is 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0242] In some embodiments, the composition described herein comprises a concentration of Dimethyl Isosorbide is between about 0.1- 1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Dimethyl Isosorbide is between about 0.1%-0.3%, between about 0.2%-0.4%, between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, or between about 0.8%- 1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Dimethyl Isosorbide is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0243] In some embodiments, the composition described herein comprises a concentration of Dimethyl Isosorbide is between about 1.1-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Dimethyl Isosorbide is between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%-1.5%, between about 1.4%- 1.6%, between about 1.5%- 1.7%, between about 1.6%-1.8%, between about 1.7%- 1.9%, or between about 1 ,8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Dimethyl Isosorbide is 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0% vol / vol, wt / vol, or wt / wt.

[0244] In some embodiments, the composition described herein comprises a concentration of Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake) between about 1.0-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake) is between about 1.0%-1.2%, between about 1.1%-1.3%, between about 1.2%-1.4%, between about 1.3%- 1.5%, between about 1.5%- 1.7%, between about 1.6%-1.8%, between about 1.7%- 1.9%, between about 1.8%-2.0%, between about 2.0%-2.2%, between about 2. l%-2.3%, between about 2.2%- 2.4%, between about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn- Ake) is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0245] In some embodiments, the composition described herein comprises a concentration of Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake) between about 3.0-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake) is between about 3.0%-3.3%, IPTS / 200163675.3 0 / 1Attorney Docket No.: VIB-030WO between about 3.2%-3.4%, between about 3.3%-3.5%, between about 3.4%-3.6%, between about 3.5%-3.7%, between about 3.6%-3.8%, between about 3.7%-3.9%, between about 3.8%-4.0%, between about 3.9%-4.1%, between about 4.0%-4.2%, between about 4.1%- 4.3%, between about 4.2%-4.4%, between about 4.3%-4.5%, between about 4.4%-4.6%, between about 4.5%-4.7%, between about 4.6%-4.8%, between about 4.7%-4.9%, or between about 4.8%-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake) is 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0246] In some embodiments, the composition described herein comprises a concentration of Dipeptide- 2between about 1.0-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Dipeptide-2 is between about 1.0%-1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%-1.5%, between about 1.5%- 1.7%, between about 1.6%- 1.8%, between about 1.7%-1.9%, between about 1.8%-2.0%, between about 2.0%-2.2%, between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Dipeptide-2 is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0247] In some embodiments, the composition described herein comprises a concentration of Dipeptide-2 between about 3.0-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Dipeptide-2 is between about 3.0%-3.3%, between about 3.2%-3.4%, between about 3.3%-3.5%, between about 3.4%-3.6%, between about 3.5%- 3.7%, between about 3.6%-3.8%, between about 3.7%-3.9%, between about 3.8%-4.0%, between about 3.9%-4.1%, between about 4.0%-4.2%, between about 4.1%-4.3%, between about 4.2%-4.4%, between about 4.3%-4.5%, between about 4.4%-4.6%, between about 4.5%-4.7%, between about 4.6%-4.8%, between about 4.7%-4.9%, or between about 4.8%- 5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Dipeptide-2 is 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0248] In some embodiments, the composition described herein comprises a concentration of Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract) is between about 0.1-1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of IPTS / 200163675.3 OCAttorney Docket No.: VIB-030WOAlpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract) is between about 0.1%- 0.3%, between about 0.2%-0.4%, between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, or between about 0.8%- 1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract) is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0249] In some embodiments, the composition described herein comprises a concentration of Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract) is between about 1.0-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract) is between about 1.0%- 1.3%, between about 1.2%- 1.4%, between about 1.3%-1.5%, between about 1.4%- 1.6%, between about 1.5%- 1.7%, between about 1.6%-1.8%, between about 1.7%- 1.9%, or between about 1 ,8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract) is 1.0% 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0%.

[0250] In some embodiments, the composition described herein comprises a concentration of Plantaserve E (Ethylhexylglycerin and Phenoxyethanol) is between about 0.1-1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Plantaserve E (Ethylhexylglycerin and Phenoxyethanol) is between about 0.1%-0.3%, between about 0.2%- 0.4%, between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, or between about 0.8%- 1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Plantaserve E (Ethylhexylglycerin and Phenoxyethanol) is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0%.

[0251] In some embodiments, the composition described herein comprises a concentration of Acetyl Hexapeptide-37 (Diffuporine) between about 0.5%- 1.0%. In some embodiments, the concentration of Acetyl Hexapeptide-37 (Diffuporine) is between about 0.50%-0.55%, between about 0.55%-0.60%, 0.60%-0.65%, between about 0.65%-0.70%, between about 0.70%-0.75%, between about 0.75%-0.80%, between about 0.80%-0.85%, between about 0.85%-0.90%, between about 0.90%-0.95%, or between about 0.95%-1.00%. In some embodiments, the concentration of Acetyl Hexapeptide-37 (Diffuporine) is 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, or 1.00% vol / vol, wt / vol, or wt / wt.

[0252] In some embodiments, the composition described herein comprises a concentration of Acetyl Hexapeptide-37 (Diffuporine) is between about 1.1-2.0% vol / vol, IPTS / 200163675.3 QAttorney Docket No.: VIB-030WG wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-37 (Diffuporine) is between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%- 1.5%, between about 1.4%- 1.6%, between about 1.5%-1.7%, between about 1.6%- 1.8%, between about 1.7%- 1.9%, or between about 1.8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-37 (Diffuporine) is 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0% vol / vol, wt / vol, or wt / wt.

[0253] In some embodiments, the composition described herein comprises a concentration of Oligopeptide-24 (EGF-like peptide) between about 0.01%-0.05%. In some embodiments, the concentration of Oligopeptide-24 (EGF-like peptide) is between about 0.010%-0.015%, between about 0.015%-0.020%, between about 0.020%-0.025%, between about 0.025%-0.030%, between about 0.030%-0.035%, between about 0.035%-0.040%, between about 0.040%-0.045%, or between about 0.045%-0.050%. In some embodiments, the concentration of Oligopeptide-24 (EGF-like peptide) is 0.010%, 0.015%, 0.020%, 0.025%, 0.030%, 0.035%, 0.040%, or 0.050% vol / vol, wt / vol, or wt / wt.

[0254] In some embodiments, the composition described herein comprises a concentration of Oligopeptide-24 (EGF-like peptide) between about 0.06%-l%. In some embodiments, the concentration of Oligopeptide-24 (EGF-like peptide) is between about 0.060%-0.1%, between about 0.1%-0.2%, between about 0.2%-0.3%, between about 0.3%- 0.4%, between about 0.4%-0.5%, between about 0.5%-0.6%, between about 0.6%-0.7%, between about 0.7%-0.8%, between about 0.8%-0.9%, between about 0.9%- 1%, or between about 0.095%-0.100%. In some embodiments, the concentration of Oligopeptide-24 (EGF- like peptide) is 0.060%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0255] In some embodiments, the composition described herein comprises a concentration of FSS Ceramide 3 between about 1.0-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of FSS Ceramide 3 is between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%-1.4%, between about 1.3%- 1.5%, between about 1.5%- 1.7%, between about 1.6%- 1.8%, between about 1.7%-1.9%, between about 1.8%- 2.0%, between about 2.0%-2.2%, between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of FSS Ceramide 3 is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.IPTS / 200163675.3 07Attorney Docket No.: VIB-030WO

[0256] In some embodiments, the composition described herein comprises a concentration of FSS Ceramide 3 between about 3.1-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of FSS Ceramide 3 is between about 3.1%-3.3%, between about 3.2%-3.4%, between about 3.3%-3.5%, between about 3.4%-3.6%, between about 3.5%-3.7%, between about 3.6%-3.8%, between about 3.7%-3.9%, between about 3.8%- 4.0%, between about 3.9%-4.1%, between about 4.0%-4.2%, between about 4.1%-4.3%, between about 4.2%-4.4%, between about 4.3%-4.5%, between about 4.4%-4.6%, between about 4.5%-4.7%, between about 4.6%-4.8%, between about 4.7%-4.9%, or between about 4.8%-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of FSS Ceramide 3 is 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0257] In some embodiments, the composition described herein comprises a concentration of Ceramide NP (Ceramide 3) between about 0.01%-0.05%. In some embodiments, the concentration of Ceramide NP (Ceramide 3) is between about 0.010%- 0.015%, between about 0.015%-0.020%, between about 0.020%-0.025%, between about 0.025%-0.030%, between about 0.030%-0.035%, between about 0.035%-0.040%, between about 0.040%-0.045%, or between about 0.045%-0.050%. In some embodiments, the concentration of Ceramide NP (Ceramide 3) is 0.010%, 0.015%, 0.020%, 0.025%, 0.030%, 0.035%, 0.040%, or 0.050% vol / vol, wt / vol, or wt / wt.

[0258] In some embodiments, the composition described herein comprises a concentration of Ceramide NP (Ceramide 3) between about 0.05%-0.1%. In some embodiments, the concentration of Ceramide NP (Ceramide 3) is between about 0.050%- 0.055%, between about 0.055%-0.060%, between about 0.060%-0.065%, between about 0.065%-0.070%, between about 0.070%-0.075%, between about 0.075%-0.080%, between about 0.080%-0.085%, between about 0.085%-0.090%, between about 0.090%-0.095%, or between about 0.095%-0.100%. In some embodiments, the concentration of Ceramide NP (Ceramide 3) is 0.060%, 0.065%, 0.070%, 0.075%, 0.080%, 0.085%, 0.090%, or 0.100% vol / vol, wt / vol, or wt / wt.

[0259] In some embodiments, the composition described herein comprises a concentration of Sodium pea between about 1.0-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Sodium pea is between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%-1.5%, between about 1.5%- 1.7%, between about 1.6%- 1.8%, between about 1.7%-1.9%, between about 1.8%-2.0%, between about 2.0%-2.2%, between about 2. l%-2.3%, between about 2.2%-2.4%, between IPTS / 200163675.3 OOAttorney Docket No.: VIB-030WG about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Sodium pea is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0260] In some embodiments, the composition described herein comprises a concentration of Sodium pea between about 3.1-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Sodium pea is between about 3.1%-3.3%, between about 3.2%-3.4%, between about 3.3%-3.5%, between about 3.4%-3.6%, between about 3.5%- 3.7%, between about 3.6%-3.8%, between about 3.7%-3.9%, between about 3.8%-4.0%, between about 3.9%-4.1%, between about 4.0%-4.2%, between about 4.1%-4.3%, between about 4.2%-4.4%, between about 4.3%-4.5%, between about 4.4%-4.6%, between about 4.5%-4.7%, between about 4.6%-4.8%, between about 4.7%-4.9%, or between about 4.8%- 5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Sodium pea is 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0261] In some embodiments, the composition described herein comprises a concentration of APT - GPF between about 0.5-1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of APT - GPF is between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, between about 0.8%-1.0%, between about 0.9%- 1.1%, between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, or between about 1.3%- 1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of APT - GPF is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, or 1.4% vol / vol, wt / vol, or wt / wt.

[0262] In some embodiments, the composition described herein comprises a concentration of APT - GPF between about 1.6-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of APT - GPF is between about 1.6%- 1.8%, between about 1.7%- 1.9%, between about 1.8%-2.0%, between about 2.0%-2.2%, between about 2.1%- 2.3%, between about 2.2%-2.4%, between about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of APT - GPF is 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.IPTS / 200163675.3 89Attorney Docket No.: VIB-030WO

[0263] In some embodiments, the composition described herein comprises a concentration of Acetyl Hexapeptide-49 (Delisens) between about 2.0-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-49 (Delisens) is between about 2.0%-2.2%, between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-49 (Delisens) is 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0264] In some embodiments, the composition described herein comprises a concentration of Acetyl Hexapeptide-49 (Delisens) between about 3.1-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-49 (Delisens) is between about 3.1%-3.3%, between about 3.2%-3.4%, between about 3.3%-3.5%, between about 3.4%-3.6%, between about 3.5%-3.7%, between about 3.6%-3.8%, between about 3.7%-3.9%, between about 3.8%-4.0%, between about 3.9%-4.1%, between about 4.0%- 4.2%, between about 4.1%-4.3%, between about 4.2%-4.4%, between about 4.3%-4.5%, between about 4.4%-4.6%, between about 4.5%-4.7%, between about 4.6%-4.8%, between about 4.7%-4.9%, or between about 4.8%-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Hexapeptide-49 (Delisens) is 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0265] In some embodiments, the composition described herein comprises a concentration of Hexapeptide-49 (Delisens) between about 0.1%-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hexapeptide-49 (Delisens) is between about 0. l%-0.5%, between about 0.5%-1.0%, between about 1.0%- 1.5%, between about 1.5%-2.0%, is between about 2.0%-2.5%, between about 2.5%-3.0%, is between about 3.0%- 3.5%, between about 3.5%-4.0%, between about 4.0%-4.5%, between about 4.5%-5.0%, between about 5.0%-5.5%, or 5.5%-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hexapeptide-49 (Delisens) is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%,2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%,3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%,5.0%, 5.5%, or 6.0% vol / vol, wt / vol, or wt / wt.

[0266] In some embodiments, the composition described herein comprises a concentration of Palmitoyl Tripeptide-38 between about 2.0-3.0% vol / vol, wt / vol, or wt / wt.IPTS / 200163675.3 QHAttorney Docket No.: VIB-030WOIn some embodiments the concentration of Palmitoyl Tripeptide-38 is between about 2.0%- 2.2%, between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl Tripeptide-38 is 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0267] In some embodiments, the composition described herein comprises a concentration of Palmitoyl tetrapeptide-7 between about 1.0-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl tetrapeptide-7 is between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%-1.4%, between about 1.3%- 1.5%, between about 1.4%- 1.6%, between about 1.5%-1.7%, between about 1.6%- 1.8%, between about 1.7%- 1.9%, or between about 1.8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl tetrapeptide-7 is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0% vol / vol, wt / vol, or wt / wt.

[0268] In some embodiments, the composition described herein comprises a concentration of Palmitoyl tetrapeptide-7 between about 2.0-4.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl tetrapeptide-7 is between about 2.0%- 2.2%, between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.4%, between about 2.4%-2.5%, between about 2.6%-2.8%, between about 2.7%-2.9%, between about 2.8%-3.0%, between about 3.0%-3.2%, between about 3.2%-3.4%, between about 3.4%-3.6%, between about 3.6%-3.8%, or between about 3.8%-4.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl tetrapeptide-7 is 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, or 4.0% vol / vol, wt / vol, or wt / wt.

[0269] In some embodiments, the composition described herein comprises a concentration of Acetyl Tetrapeptide- 15 (Skinasensyl) between about 0.3%-0.5%. In some embodiments, the concentration of Acetyl Tetrapeptide- 15 (Skinasensyl) is between about 0.300%-0.325%, between about 0.325%-0.350%, between about 0.350%-0.375%, between about 0.375%-0.400%, between about 0.400%-0.425%, between about 0.425%-0.450%, between about 0.450%-0.475%, or between about 0.475%-0.500%. In some embodiments, the concentration of Acetyl Tetrapeptide- 15 (Skinasensyl) is 0.200%, 0.225%, 0.250%, 0.275%, 0.300%, 0.325%, 0.350%, 0.375%, 0.400%, 0.425%, 0.450%, 0.475%, or 0.500% vol / vol, wt / vol, or wt / wt.IPTS / 200163675.3 91Attorney Docket No.: VIB-030WG

[0270] In some embodiments, the composition described herein comprises a concentration of Acetyl Tetrapeptide- 15 (Skinasensyl) between about 0.600%-1.000%. In some embodiments, the concentration of Acetyl Tetrapeptide- 15 (Skinasensyl) is between about 0.600%-0.625%, between about 0.625%-0.650%, between about 0.650%-0.675%, between about 0.675%-0.700%, between about 0.700%-0.725%, between about 0.725%- 0.750%, between about 0.750%-0.775%, between about 0.775%-0.800%, between about 0.800%-0.825%, between about 0.825%-0.850%, between about 0.850%-0.875%, between about 0.875%-0.900%, between about 0.900%-0.925%, between about 0.925%-0.950%, between about 0.950%-0.975%, or between about 0.975%-1.000%. In some embodiments, the concentration of Acetyl Tetrapeptide- 15 (Skinasensyl) is 0.600%, 0.625%, 0.650%, 0.675%, 0.700%, 0.725%, 0.750%, 0.775%, 0.800%, 0.825%, 0.850%, 0.875%, 0.900%, 0.925%, 0.950%, 0.975%, or 1.000% vol / vol, wt / vol, or wt / wt.

[0271] In some embodiments, the composition described herein comprises a concentration of Acetyl Tetrapeptide- 15 (Skinasensyl) between about 1.0%-3.0%. In some embodiments, the concentration of Acetyl Tetrapeptide- 15 (Skinasensyl) is between about 1.0%- 1.5%, between about 1.5%-2.0%, between about 2.0%-2.5%, between about 2.5%- 3.0%. In some embodiments, the concentration of Acetyl Tetrapeptide- 15 (Skinasensyl) is 1.0%, 1.5%, 2.0%, 2.5%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0272] In some embodiments, the composition described herein comprises a concentration of Ahnfeltiopsis concinna Extract (APT-GPF) between about 0. l%-0.5%. In some embodiments, the concentration of Ahnfeltiopsis concinna Extract (APT-GPF) is between about 0.1%-0.2%, between about 0.2%-0.3%, between about 0.3%-0.4%, or between about 0.4%-0.5%,. In some embodiments, the concentration of Ahnfeltiopsis concinna Extract (APT-GPF) is 0.1%, 0.2%, 0.3%, 0.4%, or 0.5% vol / vol, wt / vol, or wt / wt.

[0273] In some embodiments, the composition described herein comprises a concentration of Ahnfeltiopsis concinna Extract (APT-GPF) between about 0.1%-1.0%. In some embodiments, the concentration of Ahnfeltiopsis concinna Extract (APT-GPF) is between about 0.1%-0.2%, between about 0.2%-0.3%, between about 0.3%-0.4%, between about 0.4%-0.5%, between about 0.5%-0.6%, between about 0.6%-0.7%, between about 0.7%-0.8%, between about 0.8%-0.9%, or between about 0.9%-0.1%. In some embodiments, the concentration of Ahnfeltiopsis concinna Extract (APT-GPF) is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0274] In some embodiments, the composition described herein comprises a concentration of Clearthix S (Algin and Cellulose Gum) between about 0.1%-1.0%. In some IPTS / 200163675.3 QQAttorney Docket No.: VIB-030WG embodiments, the concentration of Clearthix S (Algin and Cellulose Gum) is between about 0.1%-0.2%, between about 0.2%-0.3%, between about 0.3%-0.4%, between about 0.4%- 0.5%, between about 0.5%-0.6%, between about 0.6%-0.7%, between about 0.7%-0.8%, between about 0.8%-0.9%, or between about 0.9%-0.1%. In some embodiments, the concentration of A Clearthix S (Algin and Cellulose Gum) is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0275] In some embodiments, the composition described herein comprises a concentration of Palmitoyl Tripeptide-5 between about 1.0-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl Tripeptide-5 is between about 1.0%-1.2%, between about 1.1%-1.3%, between about 1.2%-1.4%, between about 1.3%- 1.5%, between about 1.5%- 1.7%, between about 1.6%-1.8%, between about 1.7%- 1.9%, between about 1.8%-2.0%, between about 2.0%-2.2%, between about 2. l%-2.3%, between about 2.2%- 2.4%, between about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Palmitoyl Tripeptide-5 is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0276] In some embodiments, the composition described herein comprises a concentration of Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid) between about 1.0-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid) is between about 1.0%-1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%-1.5%, between about 1.5%- 1.7%, between about 1.6%- 1.8%, between about 1.7%-1.9%, between about 1.8%-2.0%, between about 2.0%-2.2%, between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%- 2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid) is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0277] In some embodiments, the composition described herein comprises a concentration of Polyacrylate Crosspolymer-6 (Seppic SepiZen) between about 0.5%-1.0%.IPTS / 200163675.3 QOAttorney Docket No.: VIB-030WOIn some embodiments, the concentration of Polyacrylate Crosspolymer-6 (Seppic SepiZen) is between about 0.50%-0.55%, between about 0.55%-0.60%, 0.60%-0.65%, between about 0.65%-0.70%, between about 0.70%-0.75%, between about 0.75%-0.80%, between about 0.80%-0.85%, between about 0.85%-0.90%, between about 0.90%-0.95%, or between about 0.95%-1.00%. In some embodiments, the concentration of Polyacrylate Crosspolymer-6 (Seppic SepiZen) is 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, or 1.00% vol / vol, wt / vol, or wt / wt.

[0278] In some embodiments, the composition described herein comprises a concentration of Sodium Hyaluronate (Medium Molecular Weight) between about 0.1%- 0.5%. In some embodiments, the concentration of Sodium Hyaluronate (Medium Molecular Weight) is between about 0.10%-0.15%, between about 0.15%-0.20%, between about 0.20%- 0.25%, between about 0.25%-0.30%, between about 0.30%-0.35%, between about 0.35%- 0.40%, between about 0.40%-0.45%, or between about 0.45%-0.50%. In some embodiments, the concentration of Sodium Hyaluronate (Medium Molecular Weight) is 0.10%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, 0.45%, or 0.50% vol / vol, wt / vol, or wt / wt.

[0279] In some embodiments, the composition described herein comprises a concentration of Sodium Hyaluronate (MMW Hyaluronic Acid) between about 0. l%-0.5%. In some embodiments, the concentration of Sodium Hyaluronate (MMW Hyaluronic Acid) is between about 0.10%-0.15%, between about 0.15%-0.20%, between about 0.20%-0.25%, between about 0.25%-0.30%, between about 0.30%-0.35%, between about 0.35%-0.40%, between about 0.40%-0.45%, or between about 0.45%-0.50%. In some embodiments, the concentration of Sodium Hyaluronate (MMW Hyaluronic Acid) is 0.10%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, 0.45%, or 0.50% vol / vol, wt / vol, or wt / wt.

[0280] In some embodiments, the composition described herein comprises a concentration of Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder) between about 0.5-1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder) is between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%- 0.9%, between about 0.8%- 1.0%, between about 0.9%-l.1%, between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%-1.4%, or between about 1.3%-1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder) is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, or 1.4% vol / vol, wt / vol, or wt / wt.IPTS / 200163675.3 94Attorney Docket No.: VIB-030WO

[0281] In some embodiments, the composition described herein comprises a concentration of Sodium Hyaluronate (Ultra Low Molecular Weight) between about 0.1%- 0.5%. In some embodiments, the concentration of Sodium Hyaluronate (Ultra Low Molecular Weight) is between about 0.10%-0.15%, between about 0.15%-0.20%, between about 0.20%- 0.25%, between about 0.25%-0.30%, between about 0.30%-0.35%, between about 0.35%- 0.40%, between about 0.40%-0.45%, or between about 0.45%-0.50%. In some embodiments, the concentration of Sodium Hyaluronate (Ultra Low Molecular Weight) is 0.10%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, 0.45%, or 0.50% vol / vol, wt / vol, or wt / wt.

[0282] In some embodiments, the composition described herein comprises a concentration of Sodium Phytate between about 0.01%-0.05%. In some embodiments, the concentration of Sodium Phytate is between about 0.010%-0.015%, between about 0.015%- 0.020%, between about 0.020% -0.025%, between about 0.025%-0.030%, between about 0.030%-0.035%, between about 0.035%-0.040%, between about 0.040%-0.045%, or between about 0.045%-0.050%. In some embodiments, the concentration of Sodium Phytate is 0.010%, 0.015%, 0.020%, 0.025%, 0.030%, 0.035%, 0.040%, or 0.050% vol / vol, wt / vol, or wt / wt.

[0283] In some embodiments, the composition described herein comprises a concentration of Sodium Phytate between about 0.05%-0.1%. In some embodiments, the concentration of Sodium Phytate is between about 0.050% -0.055%, between about 0.055%- 0.060%, between about 0.060%-0.065%, between about 0.065%-0.070%, between about 0.070%-0.075%, between about 0.075%-0.080%, between about 0.080%-0.085%, between about 0.085%-0.090%, between about 0.090%-0.095%, or between about 0.095%-0.100%. In some embodiments, the concentration of Sodium Phytate is 0.060%, 0.065%, 0.070%, 0.075%, 0.080%, 0.085%, 0.090%, or 0.100% vol / vol, wt / vol, or wt / wt.

[0284] In some embodiments, the composition described herein comprises a concentration of Sorbitol between about 0. l%-8.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Sorbitol is between about 0. l%-0.5%, between about 0.5%- 1.0%, between about 1.0%- 1.5%, between about 1.5%-2.0%, is between about 2.0%- 2.5%, between about 2.5%-3.0%, is between about 3.0%-3.5%, between about 3.5%-4.0%, between about 4.0%-4.5%, between about 4.5%-5.0%, between about 5.0%-5.5%, 5.5%- 6.0%, between about 6.0%-6.5%, 6.5%-7.0%, between about 7.0%-7.5%, or 7.5%-8.0%. . In some embodiments the concentration of Sorbitol is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, IPTS / 200163675.3 QCAttorney Docket No.: VIB-030WO3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.5%, 6.0%, 6.5%, 7.0%, 7.5%, or 8.0% vol / vol, wt / vol, or wt / wt.

[0285] In some embodiments, the composition described herein comprises a concentration of Polyquaternium-51 between about 0.5-1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Polyquaternium-51 is between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, between about 0.8%- 1.0%, between about 0.9%- 1.1%, between about 1.0%-1.2%, between about 1.1%- 1.3%, between about 1.2%- 1.4%, or between about 1.3%- 1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Polyquaternium-51 is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, or 1.4% vol / vol, wt / vol, or wt / wt.

[0286] In some embodiments, the composition described herein comprises a concentration of Polyquaternium-51 between about 1.6-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Polyquaternium-51 is between about 1.6%-2.0%, between about 2.0%-2.5%, between about 2.5%-3.0%, between about 3.0%-3.5%, between about 3.5%-4.0%, between about 4.0%-4.5%, or between about 4.5%-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Polyquatemium-51 is 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0287] In some embodiments, the composition described herein comprises a concentration of Allantoin between about 0. l%-0.5%. In some embodiments, the concentration of Allantoin is between about 0.10%-0.15%, between about 0.15%-0.20%, between about 0.20%-0.25%, between about 0.25%-0.30%, between about 0.30%-0.35%, between about 0.35%-0.40%, between about 0.40%-0.45%, or between about 0.45%-0.50%. In some embodiments, the concentration of Allantoin is 0.10%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, or 0.50% vol / vol, wt / vol, or wt / wt.

[0288] In some embodiments, the composition described herein comprises a concentration of Allantoin between about 0.6%-2.0%. In some embodiments, the concentration of Allantoin is between about 0.60%-0.70%, between about 0.70%-0.80%, between about 0.80%-0.90%, between about 0.90%-1.00%, between about 1.00%-l.10%, between about 1.20%-1.30%, between about 1.30%-1.40%, between about 1.40%-1.50%, between about 1.50%-1.60%, between about 1.60%-1.70%, between about 1.70%-1.80%, between about 1.80%- 1.90%, or between about 1.90%-2.00%. In some embodiments, theIPTS / 200163675.3 96Attorney Docket No.: VIB-030WG concentration of Allantoin is 0.60%, 0.70%, 0.80%, 0.90%, 1.00%, 1.10%, 1.20%, 1.30%, 1.40%, 1.50%, 1.60%, 1.70%, 1.80%, 1.90%, or 2.00% vol / vol, wt / vol, or wt / wt.

[0289] In some embodiments, the composition described herein comprises a concentration of Hesperdine Methyl Chaicone between about 0.3-1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hesperdine Methyl Chaicone is between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, between about 0.8%-1.0%, between about 0.9%- 1.1%, between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, or between about 1.3%- 1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hesperdine Methyl Chaicone is 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, or 1.4% vol / vol, wt / vol, or wt / wt.

[0290] In some embodiments, the composition described herein comprises a concentration of Hesperdine Methyl Chaicone between about 0.1%-1.0%. In some embodiments, the concentration of Hesperdine Methyl Chaicone is between about 0.1%- 0.2%, between about 0.2%-0.3%, between about 0.3%-0.4%, between about 0.4%-0.5%, between about 0.5%-0.6%, between about 0.6%-0.7%, between about 0.7%-0.8%, between about 0.8%-0.9%, or between about 0.9%-0.1%. In some embodiments, the concentration of Hesperdine Methyl Chaicone is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0291] In some embodiments, the composition described herein comprises a concentration of Arginine / Lysine Polypeptide between about 0.3-1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Arginine / Lysine Polypeptide is between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, between about 0.8%-1.0%, between about 0.9%- 1.1%, between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, or between about 1.3%- 1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Arginine / Lysine Polypeptide is 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, or 1.4% vol / vol, wt / vol, or wt / wt.

[0292] In some embodiments, the composition described herein comprises a concentration of Beta-Glucan between about 0.3- 1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Beta-Glucan is between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%- 0.9%, between about 0.8%- 1.0%, between about 0.9%-l.1%, between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%-1.4%, or between about 1.3%-1.5% vol / vol, IPTS / 200163675.3 Q7Attorney Docket No.: VIB-030WG wt / vol, or wt / wt. In some embodiments the concentration of Beta-Glucan is 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, or 1.4% vol / vol, wt / vol, or wt / wt.

[0293] In some embodiments, the composition described herein comprises a concentration of Bacillus Ferment (Bacillus Extract) between about 0.3-1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Bacillus Ferment (Bacillus Extract) is between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, between about 0.8%- 1.0%, between about 0.9%- 1.1%, between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, or between about 1.3%- 1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Bacillus Ferment (Bacillus Extract) is 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, or 1.4% vol / vol, wt / vol, or wt / wt.

[0294] In some embodiments, the composition described herein comprises a concentration of Butylene Glycol between about 0.3-1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Butylene Glycol is between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, between about 0.8%- 1.0%, between about 0.9%-l.1%, between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%-1.4%, or between about 1.3%-1.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Butylene Glycol is 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, or 1.4% vol / vol, wt / vol, or wt / wt.

[0295] In some embodiments, the composition described herein comprises a concentration of Hesperdine Methyl Chaicone between about 1.6-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hesperdine Methyl Chaicone is between about 1.6%- 1.8%, between about 1.7%-1.9%, between about 1.8%-2.0%, between about 2.0%-2.2%, between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%- 2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hesperdine Methyl Chaicone is 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0296] In some embodiments, the composition described herein comprises a concentration of Acetyl Tetrapeptide-40 (TELANGYN) between about 0.1-1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Tetrapeptide-40 (TELANGYN) is between about 0.1%-0.3%, between about 0.2%-0.4%, between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%-0.7%, between about 0.6%- IPTS / 200163675.3 QOAttorney Docket No.: VIB-030WG0.8%, between about 0.7%-0.9%, or between about 0.8%- 1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Tetrapep tide-40 (TELANGYN) is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0297] In some embodiments, the composition described herein comprises a concentration of Acetyl Tetrapeptide-40 (TELANGYN) between about 1.1-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Tetrapeptide-40 (TELANGYN) is between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%- 1.5%, between about 1.4%- 1.6%, between about 1.5%-1.7%, between about 1.6%- 1.8%, between about 1.7%- 1.9%, or between about 1.8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Tetrapeptide-40 (TELANGYN) is 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0% vol / vol, wt / vol, or wt / wt.

[0298] In some embodiments, the composition described herein comprises a concentration of Acetyl Dipeptide-3 Aminohexanoate (Bodyfensine) between about 2.0-3.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Dipeptide-3 Aminohexanoate (Bodyfensine) is between about 2.0%-2.2%, between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, between about 2.8%-3.0%, between about 2.9%-3.1%, between about 3.0%-3.2%, between about 3.1%-3.3%, between about 3.2%- 3.4%, or between about 3.3%-3.5% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Dipeptide-3 Aminohexanoate (Bodyfensine) is 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, or 3.5% vol / vol, wt / vol, or wt / wt.

[0299] In some embodiments, the composition described herein comprises a concentration of Acetyl Dipeptide-3 Aminohexanoate (Bodyfensine) between about 3.6-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Dipeptide-3 Aminohexanoate (Bodyfensine) is between about 3.6%-3.8%, between about 3.7%-3.9%, between about 3.8%-4.0%, between about 3.9%-4.1%, between about 4.0%-4.2%, between about 4.1%-4.3%, between about 4.2%-4.4%, between about 4.3%-4.5%, between about 4.4%-4.6%, between about 4.5%-4.7%, between about 4.6%-4.8%, between about 4.7%- 4.9%, or between about 4.8%-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Dipeptide-3 Aminohexanoate (Bodyfensine) is 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.IPTS / 200163675.3 99Attorney Docket No.: VIB-030WO

[0300] In some embodiments, the composition described herein comprises a concentration of Acetyl Tetrapeptide-2 (Syn-UP) between about 0.5%-1.0%. In some embodiments, the concentration of Acetyl Tetrapeptide-2 (Syn-UP) is between about 0.50%- 0.55%, between about 0.55%-0.60%, 0.60%-0.65%, between about 0.65%-0.70%, between about 0.70%-0.75%, between about 0.75%-0.80%, between about 0.80%-0.85%, between about 0.85%-0.90%, between about 0.90%-0.95%, or between about 0.95%-1.00%. In some embodiments, the concentration of Acetyl Tetrapeptide-2 (Syn-UP) is 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, or 1.00% vol / vol, wt / vol, or wt / wt.

[0301] In some embodiments, the composition described herein comprises a concentration of Acetyl Tetrapeptide-2 (Syn-UP) is between about 1.1-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Tetrapeptide-2 (Syn-UP) is between about 1.1%-1.3%, between about 1.2%-1.4%, between about 1.3%- 1.5%, between about 1.4%- 1.6%, between about 1.5%-1.7%, between about 1.6%- 1.8%, between about 1.7%- 1.9%, between about 1.8%-2.0%, 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.5%, between about 2.4%-2.6%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0%. In some embodiments the concentration of Acetyl Tetrapeptide-2 (Syn-UP) is 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0%.

[0302] In some embodiments, the composition described herein comprises a concentration of Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex) between about 0.1%-1.0%. In some embodiments, the concentration of Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex) is between about 0.1%-0.2%, between about 0.2%-0.3%, between about 0.3%-0.4%, between about 0.4%-0.5%, between about 0.5%-0.6%, between about 0.6%-0.7%, between about 0.7%-0.8%, between about 0.8%- 0.9%, or between about 0.9%-0.1%. In some embodiments, the concentration of Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex) is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0%.

[0303] In some embodiments, the composition described herein comprises a concentration of Hexapeptide-2 between about 0. l%-0.5%. In some embodiments, the concentration of Hexapeptide-2 is between about 0.10%-0.15%, between about 0.15%- 0.20%, between about 0.20%-0.25%, between about 0.25%-0.30%, between about 0.30%- 0.35%, between about 0.35%-0.40%, between about 0.40%-0.45%, or between about 0.45%- 0.50%. In some embodiments, the concentration of Hexapeptide-2 is 0.10%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, or 0.50% vol / vol, wt / vol, or wt / wt.IPTS / 200163675.3 1 nnAttorney Docket No.: VIB-030WG

[0304] In some embodiments, the composition described herein comprises a concentration of Hexapeptide-2 between about 0.6%-1.0%. In some embodiments, the concentration of Hexapeptide-2 is between about 0.60%-0.65%, between about 0.65%- 0.70%, between about 0.70%-0.75%, between about 0.75%-0.80%, between about 0.80%- 0.85%, between about 0.85%-0.90%, between about 0.90%-0.95%, or between about 0.95%- 1.00%. In some embodiments, the concentration of Hexapeptide-2 is 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, or 1.00% vol / vol, wt / vol, or wt / wt.

[0305] In some embodiments, the composition described herein comprises a concentration of Nonapeptide- 1 (Melanostatine) between about 0.1%-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Nonapeptide- 1 (Melanostatine) is between about 0. l%-0.5%, between about 0.5%-1.0%, between about 1.0%- 1.5%, between about 1.5%-2.0%, is between about 2.0%-2.5%, between about 2.5%-3.0%, is between about 3.0%- 3.5%, between about 3.5%-4.0%, between about 4.0%-4.5%, between about 4.5%-5.0%, between about 5.0%-5.5%, or 5.5%-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Nonapeptide- 1 (Melanostatine) is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%,0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%,2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%,3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%,4.9%, 5.0%, 5.5%, or 6.0% vol / vol, wt / vol, or wt / wt.

[0306] In some embodiments, the composition described herein comprises a concentration of Nonapeptide- 1 (Melanostatine) between about 5.1% and 10.0%. In some embodiments, the concentration of Nonapeptide- 1 (Melanostatine) is between about 5.1%- 5.5%, between about 5.5%-6.0%, between about 6.0%-6.5%, between about 6.5%-7.0%, between about 7.0%-7.5%, between about 7.5%-8.0%, between about 8.0%-8.5%, between about 8.5%-9.0%, between about 9.0%-9.5%, or between about 9.5%-10.0%. In some embodiments, the concentration of Nonapeptide- 1 (Melanostatine) is 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6.0%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%,6.8%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8.0%, 8.1%,8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%,9.6%, 9.7%, 9.8%, 9.9%, or 10.0% vol / vol, wt / vol, or wt / wt.

[0307] In some embodiments, the composition described herein comprises a concentration of Glycerin between about 0.1%-7.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Glycerin is between about 0. l%-0.5%, between about 0.5%- 1.0%, between about 1.0%- 1.5%, between about 1.5%-2.0%, is between about 2.0%- IPTS / 200163675.3 i niAttorney Docket No.: VIB-030WO2.5%, between about 2.5%-3.0%, is between about 3.0%-3.5%, between about 3.5%-4.0%, between about 4.0%-4.5%, between about 4.5%-5.0%, between about 5.0%-5.5%, 5.5%- 6.0%, between about 6.0%-6.5%, or 6.5%-7.0%. In some embodiments the concentration of Glycerin is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.5%, 6.0%, 6.5%, or 7.0%.

[0308] In some embodiments, the composition described herein comprises a concentration of Decapeptide- 12 between about 0. l%-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Decapeptide- 12 is between about 0. l%-0.5%, between about 0.5%- 1.0%, between about 1.0%-1.5%, between about 1.5%-2.0%, is between about 2.0%-2.5%, between about 2.5%-3.0%, is between about 3.0%-3.5%, between about 3.5%- 4.0%, between about 4.0%-4.5%, between about 4.5%-5.0%, between about 5.0%-5.5%, or 5.5%-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Decapeptide- 12 is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0309] In some embodiments, the composition described herein comprises a concentration of Decapeptide- 12 between about 5.1% and 10.0%. In some embodiments, the concentration of Decapeptide- 12 is between about 5.1%-5.5%, between about 5.5%-6.0%, between about 6.0%-6.5%, between about 6.5%-7.0%, between about 7.0%-7.5%, between about 7.5%-8.0%, between about 8.0%-8.5%, between about 8.5%-9.0%, between about 9.0%-9.5%, or between about 9.5%-10.0%. In some embodiments, the concentration of Decapeptide- 12 is 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6.0%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8.0%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, or 10.0% vol / vol, wt / vol, or wt / wt.

[0310] In some embodiments, the composition described herein comprises a concentration of Decapeptide 12 between about 2.0-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Decapeptide 12 is between about 2.0%-2.5%, between about 2.5%-3.0%, between about 3.0%-3.5%, between about 3.5%-4.0%, between about IPTS / 200163675.3 102Attorney Docket No.: VIB-030WO4.0%-4.5%, between about 4.5%-5.0%, between about 5.0%-5.5%, or 5.5%-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Decapeptide 12 is 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, or 6.0% vol / vol, wt / vol, or wt / wt.

[0311] In some embodiments, the composition described herein comprises a concentration of Decapeptide 12 between about 6.0% and 10.0%. In some embodiments, the concentration of Decapeptide 12 is between about 6.0%-6.5%, between about 6.5%-7.0%, between about 7.0%-7.5%, between about 7.5%-8.0%, between about 8.0%-8.5%, between about 8.5%-9.0%, between about 9.0%-9.5%, or between about 9.5%-10.0%. In some embodiments, the concentration of Decapeptide 12 is 6.0%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8.0%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, or 10.0% vol / vol, wt / vol, or wt / wt.

[0312] In some embodiments, the composition described herein comprises a concentration of Acetyl Tetrapeptide-5 (Eyeseryl) between about 1.0%-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Tetrapeptide-5 (Eyeseryl) is between about 1.0%- 1.5%, between about 1.5%-2.0%, is between about 2.0%-2.5%, between about 2.5%-3.0%, is between about 3.0%-3.5%, between about 3.5%-4.0%, between about 4.0%-4.5%, between about 4.5%-5.0%, between about 5.0%-5.5%, or 5.5%-6.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Acetyl Tetrapeptide-5 (Eyeseryl) is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0313] In some embodiments, the composition described herein comprises a concentration of Acetyl Tetrapeptide-5 (Eyeseryl) between about 5.1% and 10.0%. In some embodiments, the concentration of Acetyl Tetrapeptide-5 (Eyeseryl) is between about 5.1%- 5.5%, between about 5.5%-6.0%, between about 6.0%-6.5%, between about 6.5%-7.0%, between about 7.0%-7.5%, between about 7.5%-8.0%, between about 8.0%-8.5%, between about 8.5%-9.0%, between about 9.0%-9.5%, or between about 9.5%-10.0%. In some embodiments, the concentration of Acetyl Tetrapeptide-5 (Eyeseryl) is 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6.0%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8.0%, 8.1%, IPTS / 200163675.3 103Attorney Docket No.: VIB-030WG8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, or 10.0% vol / vol, wt / vol, or wt / wt.

[0314] In some embodiments, the composition described herein comprises a concentration of Caffeine between about 0.1-1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Caffeine is between about 0.1%-0.3%, between about 0.2%-0.4%, between about 0.3%-0.5%, between about 0.4%-0.6%, between about 0.5%- 0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, or between about 0.8%-1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Caffeine is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0315] In some embodiments, the composition described herein comprises a concentration of Caprylyl / Capryl Glucoside & Water & Sodium Cocoyl Glutamate & Glyceryl Caprylate & Citric Acid & Poly glyceryl- 6 Oleate & Sodium Surfactin (Naturesolv) between about 0.1-1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Caprylyl / Capryl Glucoside & Water & Sodium Cocoyl Glutamate & Glyceryl Caprylate & Citric Acid & Poly glyceryl- 6 Oleate & Sodium Surfactin (Naturesolv) is between about 0.1%-0.3%, between about 0.2%-0.4%, between about 0.3%-0.5%, between about 0.4%- 0.6%, between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, or between about 0.8%- 1.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Caprylyl / Capryl Glucoside & Water & Sodium Cocoyl Glutamate & Glyceryl Caprylate & Citric Acid & Poly glyceryl- 6 Oleate & Sodium Surfactin (Naturesolv) is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0% vol / vol, wt / vol, or wt / wt.

[0316] In some embodiments, the composition described herein comprises a concentration of Caffeine between about 0.5-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Caffeine is between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, between about 0.8%-1.0%, between about 0.9%- 1.1%, between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%- 1.5%, between about 1.4%-1.6%, between about 1.5%- 1.7%, between about 1.6%-1.8%, between about 1.7%-1.9%, or between about 1.8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Caffeine is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0% vol / vol, wt / vol, or wt / wt.

[0317] In some embodiments, the composition described herein comprises a concentration of Caffeine between about 2.1-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Caffeine is between about 2. l%-2.3%, between about IPTS / 200163675.3 1 fj / 1Attorney Docket No.: VIB-030WO2.2%-2.4%, between about 2.3%-2.4%, between about 2.4%-2.5%, between about 2.6%- 2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Caffeine is 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0318] In some embodiments, the composition described herein comprises a concentration of DAP Tripeptide 33 between about 0.5-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of DAP Tripeptide 33 is between about 0.5%-0.7%, between about 0.6%-0.8%, between about 0.7%-0.9%, between about 0.8%- 1.0%, between about 0.9%- 1.1%, between about 1.0%-1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%- 1.5%, between about 1.5%-1.7%, between about 1.6%- 1.8%, between about 1.7%- 1.9%, between about 1.8%-2.0%, between about 2.0%-2.2%, between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.5%, between about 2.5%-2.7%, between about 2.6%-2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of DAP Tripeptide 33 is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0319] In some embodiments, the composition described herein comprises a concentration of DAP Tripeptide 33 between about 3.1-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of DAP Tripeptide 33 is between about 3.1%-3.3%, between about 3.2%-3.4%, between about 3.3%-3.5%, between about 3.4%-3.6%, between about 3.5%-3.7%, between about 3.6%-3.8%, between about 3.7%-3.9%, between about 3.8%-4.0%, between about 3.9%-4.1%, between about 4.0%-4.2%, between about 4.1%- 4.3%, between about 4.2%-4.4%, between about 4.3%-4.5%, between about 4.4%-4.6%, between about 4.5%-4.7%, between about 4.6%-4.8%, between about 4.7%-4.9%, or between about 4.8%-5.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of DAP Tripeptide 33 is 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5.0% vol / vol, wt / vol, or wt / wt.

[0320] In some embodiments, the composition described herein comprises a concentration of Pepha-tight between about 1.0-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Pepha-tight is between about 1.0%-1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%-1.5%, between about 1.4%- 1.6%, between about 1.5%- 1.7%, between about 1.6%-1.8%, between about 1.7%- 1.9%, or between about 1 ,8%-2.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration IPTS / 200163675.3 | Q5Attorney Docket No.: VIB-030WO of Pepha-tight is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0% vol / vol, wt / vol, or wt / wt.

[0321] In some embodiments, the composition described herein comprises a concentration of Pepha-tight between about 2.1-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Pepha-tight is between about 2. l%-2.3%, between about 2.2%-2.4%, between about 2.3%-2.4%, between about 2.4%-2.5%, between about 2.6%- 2.8%, between about 2.7%-2.9%, or between about 2.8%-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Pepha-tight is 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0% vol / vol, wt / vol, or wt / wt.

[0322] In some embodiments, the composition described herein comprises a concentration of Ferulic acid between about 0.01%-0.1%. In some embodiments, the concentration of Ferulic acid is between about 0.010%-0.015%, between about 0.015%- 0.020%, between about 0.020% -0.025%, between about 0.025%-0.030%, between about 0.030%-0.035%, between about 0.035%-0.040%, between about 0.040%-0.045%, between about 0.045%-0.050%, between about 0.050% -0.055%, between about 0.055% -0.060%, between about 0.060%-0.065%, between about 0.065%-0.070%, between about 0.070%- 0.075%, between about 0.075%-0.080%, between about 0.080% -0.085%, between about 0.085%-0.090%, or between about 0.095%-0.100%. In some embodiments, the concentration of Ferulic acid is 0.010%, 0.015%, 0.020%, 0.025%, 0.030%, 0.035%, 0.040%, 0.045%, 0.050%, 0.055%, 0.065%, 0.070%, 0.075%, 0.080%, 0.085%, 0.090%, 0.095%, or 0.100%.

[0323] In some embodiments, the composition described herein comprises a concentration of Ferulic acid between about 0.1%-1.0%. In some embodiments, the concentration of Ferulic acid is between about 0.1%-0.2%, between about 0.2%-0.3%, between about 0.3%-0.4%, between about 0.4%-0.5%, between about 0.5%-0.6%, between about 0.6%-0.7%, between about 0.7%-0.8%, between about 0.8%-0.9%, or between about 0.9%-0.1%. In some embodiments, the concentration of Ferulic acid is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0%.

[0324] In some embodiments, the composition described herein comprises a concentration of Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer (Sepinov) between about 0.01%-0.1%. In some embodiments, the concentration of Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer (Sepinov) is between about 0.010%-0.015%, between about 0.015%-0.020%, between about 0.020% -0.025%, between about 0.025%-0.030%, between about 0.030%-0.035%, between about 0.035%- 0.040%, between about 0.040% -0.045%, between about 0.045%-0.050%, between about IPTS / 200163675.3 106Attorney Docket No.: VIB-030WO0.050%-0.055%, between about 0.055%-0.060%, between about 0.060%-0.065%, between about 0.065%-0.070%, between about 0.070%-0.075%, between about 0.075%-0.080%, between about 0.080%-0.085%, between about 0.085%-0.090%, or between about 0.095%- 0.100%. In some embodiments, the concentration of Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer (Sepinov) is 0.010%, 0.015%, 0.020%, 0.025%, 0.030%, 0.035%, 0.040%, 0.045%, 0.050%, 0.055%, 0.065%, 0.070%, 0.075%, 0.080%, 0.085%, 0.090%, 0.095%, or 0.100%.

[0325] In some embodiments, the composition described herein comprises a concentration of Hydroxypropyl Tetrahydropyrantriol (Proxylane) between about 0.5%-1.0%. In some embodiments, the concentration of Hydroxypropyl Tetrahydropyrantriol (Proxylane) is between about 0.50%-0.55%, between about 0.55%-0.60%, 0.60%-0.65%, between about 0.65%-0.70%, between about 0.70%-0.75%, between about 0.75%-0.80%, between about 0.80%-0.85%, between about 0.85%-0.90%, between about 0.90%-0.95%, or between about 0.95%-1.00%. In some embodiments, the concentration of Hydroxypropyl Tetrahydropyrantriol (Proxylane) is 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, or 1.00% vol / vol, wt / vol, or wt / wt.

[0326] In some embodiments, the composition described herein comprises a concentration of Hydroxypropyl Tetrahydropyrantriol (Proxylane) is between about 1.0-3.0% vol / vol, wt / vol, or wt / wt. In some embodiments the concentration of Hydroxypropyl Tetrahydropyrantriol (Proxylane) is between about 1.0%- 1.2%, between about 1.1%-1.3%, between about 1.2%- 1.4%, between about 1.3%-1.5%, between about 1.4%- 1.6%, b...

Claims

1. Atorney Ref: VIB-030USPRClaims1. A method for treating a skin condition of a subject, the method comprising administering a customized skin regimen to the skin of the subject, wherein the customized skin regimen was determined for the subject by: for one or more skin activity categories, each skin activity category comprising at least one compound being considered for inclusion in the customized skin regimen: obtaining or having obtained one or more images captured of the subject’s skin; determining a phenotype score for one or more skin activity categories for the subject using the one or more images; assigning a phenotype treatment category to each of the one or more skin activity categories for the subject based on the phenotype score; and for the phenotype treatment category, determining a fixed value for each of a plurality of elements of the skin activity category using the corresponding treatment category.

2. A method for determining a customized skin regimen for a subject, the method comprising: for one or more skin activity categories, each skin activity category comprising at least one compound being considered for inclusion in the customized skin regimen: obtaining or having obtained one or more images captured of the subject’s skin; determining a phenotype score for one or more skin activity categories for the subject using the one or more images; and ; assigning a phenotype treatment category to each of the one or more skin activity categories for the subject based on the phenotype score and for the phenotype treatment category, determining a fixed value for each of a plurality of elements of the skin activity category using the corresponding treatment category.

3. The method of claim 1 or 2, wherein the one or more skin activity categories comprise an anti-aging and wrinkle reduction category, a lymphatic drainage category, a skin firming and elasticity category, a brightening and pigmentation category, a UV / oxidative damage / DNA / cell damage category, an anti-inflammatory and soothing category, and a hydration and skin barrier repair category.IPTS / 200163675.3 217Atorney Ref: VIB-030USPR4. The method of any of claims 1-3, wherein the phenotype treatment category is determined to be a moderate category or a severe category.

5. The method of any of claims 1-4, wherein determining the phenotype score for the skin activity category comprises determining a first value from the one or more images of the subject’s skin and determining a second value from a questionnaire including a set of questions related to the skin activity category.

6. The method of claim 5, wherein determining the phenotype score for the skin activity category comprises determining a phenotype treatment category score for the skin activity category by getting a sum of the first value determined from the image and the second value determined from the questionnaire and determining the phenotype treatment category for each skin activity category based on the sum of the first value and the second value.

7. The method of any one of claims 1-6, wherein the at least one compound for each skin activity category comprises one or more peptide, vitamin, mineral, acid, prebiotic or probiotic.

8. The method of claim 7, wherein the one or more peptide for the anti-aging and wrinkle reduction category comprise one or more of palmitoyl pentapeptide-4 (Matrixyl), acetyl dipeptide- 1 cetyl ester (Idealift), acetyl hexapeptide-8 (Argireline), acetyl hexapeptide- 30 (InylineO-Peptide), acetyl hexapeptide- 51 amide (Juveleven), Argirelox (Pentapeptide 18+Argireline), SNAP 8-acetyl octapeptide-3, Pal-Tripeptide 5, GHK Cu, Reproage™, Synake, palmitoyl pentapeptide 38, or Tripeptide-29.

9. The method of claim 7 or 8, wherein the one or more peptide for the lymphatic drainage category comprises eyeseryl-acetyl tetrapeptide-5 or Dipeptide-2.

10. The method of any one of claims 6-8, wherein the one or more peptide for the skin firming and elasticity category comprise one or more of palmitoyl hexapeptide- 12 (Biopeptide EL), palmitoyl oligopeptide (Bio-bustyl), myristoyl pentapeptide- 8 (SymPeptide 222), palmitoyl oligopeptide (Biopeptide CL), acetyl heptapeptide 4 (Fensebiome), triptide- 10 citrulline (Decorinyl), hexapeptide- 10 (Serilesine), acetyl tetrapeptide- 11 (Syniorage), acetyl hexapeptide-38 (Adifyline), hexapeptide- 11 (Peptide Vinci 2), acetyl dipeptide- 13 diphenylglycine (Relistase), Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate), or acetyl tetrapeptide- 2 (Uplevity).

11. The method of any one of claims 7-9, wherein the one or more peptides for the hydration and skin barrier repair category comprise one or more of Decapeptide-4, acetylIPTS / 200163675.3 218Atorney Ref: VIB-030USPR hexapeptide-37 (Diffuporine), Oligopeptide-24 (EGF-like peptide), FSS Ceramide 3, sodium pea, or APT-GPF.

12. The method of any one of claims 7-11, wherein the one or more peptides for the antiinflammatory and soothing category comprise one or more of acetyl hexapeptide-49 (Delisens), palmitoyl tetrapeptide-7, acetyl tetrapeptide- 15 (Skinasensyl), polyquaternium-51, allantoin, hesperdine methyl chaicone, acetyl tetrapeptide-40 (TELANGYN), acetyl dipeptide-3 aminohexanoate (Bodyfensine), Oligopeptide- 10, or Acetyl Tetrapeptide- 2 (Syn- UP).

13. The method of any one of claims 7-12, wherein the one or more peptides for the brightening and pigmentation category comprise one or more of Hexapeptide-2, Nonapeptide-1 (Melanostatine), Decapeptide 12, Oligopeptide-34, Oligopeptide-51 or Tetrapep tide-30.

14. The method of any one of claims 7-13, wherein the one or more peptides for the UV / Oxidative Damage / DNA / Cell damage category comprise one or more of DAP tripeptide 33, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), ferulic acid, acetyl tetrapeptide-22 (Thermostressine), acetyl heptapeptide- 1, or tripeptide-9 citrulline (dGlyage).

15. The method of any one of claims 1-14, wherein the at least one compound comprises one or more prebiotic or probiotic.

16. The method of claim 15, wherein the one or more prebiotic and probiotic comprise one or more of Pepha active, beta glucan, Bacillus extract, sea kelp extract, or alpaflor sebum.

17. The method of any one of claims 1-16, wherein the at least one compound further comprises one or more vitamins.

18. The method of claim 17, wherein the one or more vitamins comprises one or more of D-Panthenol, magnesium ascorbyl phosphate, tocopherols, or niacinamide.

19. The method of any one of claims 1-18, wherein the customized skin regimen further comprises one or more base compounds.

20. The method of any one of claims 1-19, further comprising: obtaining or having obtained one or more demographics of the subject; and determining the customized skin regimen for the subject based on the demographics of the subject.

21. The method of claim 20, wherein the demographics comprise one or more of an age or gender of the subject.

22. The method of any one of claims 1-21, further comprising: obtaining or having obtained an image of a face from the subject;IPTS / 200163675.3 219Atorney Ref: VIB-030USPR grading severities of one or more phenotypic parameters for the face of the subject based on the image; and determining the customized skin regimen for the subject based on the severity of the one or more phenotypic parameters.

23. The method of claim 22, wherein the phenotypic parameters comprise one or more of wrinkles, periorbital- around eyes (puffy eyes), nasolabial folds (laugh lines), worry lines, uneven skin tone / pigmentation, or age spots (liver spots).

24. The method of any one of claims 1-23, further comprising: obtaining or having obtained one or more responses to a skin questionnaire from the subject; and determining the customized skin regimen for the subject based on the one or more responses from the subject.

25. The method of claim 24, wherein the skin questionnaire comprises one or more questions related to skin goals, type of skin, sun exposure, or skin proneness to external factors.

26. The method of any one of claims 1-25, wherein based on the phenotype score, the phenotype treatment category for:(a) the anti-aging and wrinkle reduction category is moderate or severe;(b) the lymphatic drainage category is moderate or severe;(c) the skin firming and elasticity category is moderate or severe;(d) the brightening and pigmentation category is moderate or severe;(e) the UV / oxidative damage / DNA / cell damage category is moderate or severe;(f) the anti-inflammatory and soothing category is moderate or severe ; and / or(g) the hydration and skin barrier repair category is moderate or severe.

27. The method of claim 26, wherein the anti-aging and wrinkle reduction category is moderate.

28. The method of claim 27, wherein the customized skin regimen comprises one or more of palmitoyl pentapeptide-4 (Matrixyl), acetyl dipeptide- 1 cetyl ester (Idealift), acetyl hexapeptide-8 (Argireline), acetyl hexapeptide-30 (InylineO-Peptide), acetyl hexapeptide- 51 amide (Juveleven), Argirelox (Pentapeptide 18+Argireline), SNAP 8-acetyl octapeptide-3, Pal-Tripeptide 5, GHK Cu, Reproage™, Synake, and palmitoyl pentapeptide 38.

29. The method of claim 28, wherein the customized skin regimen comprises one or more of:(a) 0.5%-l% palmitoyl pentapeptide-4 (Matrixyl),IPTS / 200163675.3 30Atorney Ref: VIB-030USPR(b) 3% acetyl dipeptide- 1 cetyl ester (Idealift),(c) 3%-6% acetyl hexapeptide-8 (Argireline),(d) 3%-4% acetyl hexapeptide- 30 (InylineO-Peptide),(e) 0.5%-1.4% acetyl hexapeptide- 51 amide (Juveleven),(f) 3% -6% Argirelox (Pentapeptide 18+ Argireline),(g) l%-2% SNAP 8-acetyl octapeptide-3,(h) l%-2% Pal-Tripeptide 5,(i) 0.1%-0.3% GHK Cu,(j) 0.1%-l% Reproage™,(k) l%-2% Synake,(l) 2%-3% palmitoyl pentapeptide 38, and / or(m)0.1%-0.5% Tripeptide-29.

30. The method of claim 26, wherein the anti-aging and wrinkle reduction category is severe.

31. The method of claim 30, wherein the customized skin regimen tcomprises one or more of palmitoyl pentapeptide-4 (Matrixyl), acetyl dipeptide- 1 cetyl ester (Idealift), acetyl hexapeptide-8 (Argireline), acetyl hexapeptide-30 (InylineO-Peptide), acetyl hexapeptide- 51 amide (Juveleven), Argirelox (Pentapeptide 18+Argireline), SNAP 8-acetyl octapeptide-3, Pal-Tripeptide 5, GHK Cu, Reproage™, Synake, and palmitoyl pentapeptide 38.

32. The method of claim 31, wherein the customized skin regimen comprises one or more of:(a) l%-3% palmitoyl pentapeptide-4 (Matrixyl),(b) 4% acetyl dipeptide- 1 cetyl ester (Idealift),(c) 6.1%-10% acetyl hexapeptide-8 (Argireline),(d) 4. l%-5% acetyl hexapeptide-30 (InylineO-Peptide),(e) 1.5%-2% acetyl hexapeptide- 51 amide (Juveleven),(f) 6.1%- 10% Argirelox (Pentapeptide 18+Argireline),(g) 2%-4% SNAP 8-acetyl octapeptide-3,(h) 2. l%-3% Pal-Tripeptide 5,(i) 0.3%-0.5% GHK Cu,(j) l.l%-2% Reproage™,(k) 2.1%-4% Synake,(l) 3.1% -4% palmitoyl pentapeptide 38, and / or(m)0.6%-l% Tripeptide-29.IPTS / 200163675.3 221Atorney Ref: VIB-030USPR33. The method of any one of claims 26-32, wherein the lymphatic drainage category is moderate.

34. The method of claim 33, wherein the customized skin regimen comprises one or more of eyeseryl-acetyl tetrapeptide- 5, Caffeine, and / or Dipeptide-2.

35. The method of claim 34, wherein the customized skin regimen comprises one or more of:(a) l%-5% eyeseryl-acetyl tetrapeptide- 5,(b) 0.5%-2% Caffeine, and / or,(c) 0.5%-2% Dipeptide-2.

36. The method of any one of claims 26-32, wherein the lymphatic drainage category is severe.

37. The method of claim 36, wherein the customized skin regimen comprises one or more of eyeseryl-acetyl tetrapeptide- 5, and / or Caffeine.

38. The method of claim 37, wherein the customized skin regimen comprises one or more of:(a) 5.1%-10% eyeseryl-acetyl tetrapeptide- 5,(b) 2. l%-3% Caffeine, and / or,(c) 2%-4% Dipeptide-2.

39. The method of any one of claims 26-38, wherein the hydration and skin barrier repair category is moderate.

40. The method of claim 39, wherein the customized skin regimen comprises one or more of Decapeptide-4, acetyl hexapeptide-37 (Diffuporine), Oligopeptide-24 (EGF-like peptide), FSS Ceramide 3, sodium pea, and / or APT-GPF.

41. The method of claim 40, wherein the customized skin regimen comprises one or more of:(a) l%-3% Decapeptide-4,(b) 0.5%- 1% acetyl hexapeptide-37 (Diffuporine),(c) 0.01%-0.05% Oligopeptide-24 (EGF-like peptide),(d) l%-3% FSS Ceramide 3,(e) l%-3% sodium pea, and / or(f) 0.1%-0.4% APT-GPF.

42. The customized skin regimen of any one of claims 26-38, wherein the hydration and skin barrier repair category is severe.IPTS / 200163675.3 222Atorney Ref: VIB-030USPR43. The method of claim 42, wherein the customized skin regimen comprises one or more of Decapeptide-4, acetyl hexapeptide-37 (Diffuporine), Oligopeptide-24 (EGF-like peptide), FSS Ceramide 3, sodium pea, and / or APT-GPF.

44. The method of claim 43, wherein the customized skin regimen comprises one or more of:(a) 3. l%-5% Decapeptide-4,(b) l.l%-2% acetyl hexapeptide-37 (Diffuporine),(c) 0.06%- 1% Oligopeptide-24 (EGF-like peptide),(d) 3.1%5% FSS Ceramide 3,(e) 3.1%5% sodium pea, and / or(f) 0.4%-l% APT-GPF.

45. The method of any one of claims 26-44, wherein the anti-inflammatory and soothing category is moderate.

46. The method of claim 45, wherein the customized skin regimen comprises one or more of acetyl hexapeptide-49 (Delisens), palmitoyl tetrapep tide-7, acetyl tetrapeptide- 15 (Skinasensyl), polyquatemium-51, allantoin, hesperdine methyl chaicone, acetyl tetrapeptide- 40 (TELANGYN), acetyl dipeptide-3 aminohexanoate (Bodyfensine), Oligopeptide- 10, Acetyl Tetrapeptide-2 (Syn-UP), or Hydroxypropyl Tetrahydropyrantriol (Proxylane).

47. The method of claim 46, wherein the customized skin regimen comprises one or more of:(a) 2%-3% acetyl hexapeptide-49 (Delisens),(b) l%-2% palmitoyl tetrapeptide-7,(c) 0.3%-0.5% acetyl tetrapeptide- 15 (Skinasensyl),(d) 0.5%-1.5% polyquatemium-51,(e) 0.1%-0.5% allantoin,(f) 0.1%-0.3% hesperdine methyl chaicone,(g) 0.1%- 1% acetyl tetrapeptide-40 (TELANGYN),(h) 2%-3.5% acetyl dipeptide-3 aminohexanoate (Bodyfensine),(i) Oligopeptide- 10,(j) 0.5%- 1% % Acetyl Tetrapeptide-2 (Syn-UP), and / or(k) 0.5%- 1% Hydroxypropyl Tetrahydropyrantriol (Proxylane).

48. The method of any one of claims 26-44, wherein the anti-inflammatory and soothing category is severe.IPTS / 200163675.3 223Atorney Ref: VIB-030USPR49. The method of claim 48, wherein the customized skin regimen comprises one or more of acetyl hexapeptide-49 (Delisens), palmitoyl tetrapep tide-7, acetyl tetrapeptide- 15 (Skinasensyl), polyquatemium-51, allantoin, hesperdine methyl chaicone, acetyl tetrapeptide- 40 (TELANGYN), acetyl dipeptide-3 aminohexanoate (Bodyfensine), Oligopeptide- 10, Acetyl Tetrapeptide-2 (Syn-UP), or Hydroxypropyl Tetrahydropyrantriol (Proxylane).

50. The method of claim 49, wherein the customized skin regimen comprises one or more of:(a) 3. l%-5% acetyl hexapeptide-49 (Delisens),(b) 2.1%-3% palmitoyl tetrapeptide-7,(c) 0.6%-2% acetyl tetrapeptide- 15 (Skinasensyl),(d) 1.6%-5% polyquaternium-51,(e) 0.6%-2% allantoin,(f) 0.4%-0.6% hesperdine methyl chaicone,(g) 1.1%-2% acetyl tetrapeptide-40 (TELANGYN),(h) 3.6%-5% acetyl dipeptide-3 aminohexanoate (Bodyfensine),(i) Oligopeptide- 10, and / or(j) 1.1%-3% Acetyl Tetrapeptide-2 (Syn-UP), and / or(k) 1.1%-2% Hydroxypropyl Tetrahydropyrantriol (Proxylane).

51. The method of any one of claims 26-50, wherein the brightening and pigmentation category is moderate.

52. The method of claim 51, wherein the customized skin regimen comprises one or more of Hexapeptide- 2, Nonapeptide- 1 (Melanostatine), Decapeptide 12, Oligopeptide-34, Oligopeptide-51, or Tetrapeptide-30.

53. The method of claim 52, wherein the customized skin regimen comprises one or more of:(a) 0.1%-0.5% of Hexapep tide-2,(b) 0. l%-5% Nonapeptide-1 (Melanostatine),(c) 2%-6% Decapeptide 12,(d) Oligopeptide-34,(e) Oligopeptide-51, and / or(f) 0.5%-2% Tetrapeptide-30.

54. The method of any one of claims 26-50, wherein the brightening and pigmentation category is severe.IPTS / 200163675.3 224Atorney Ref: VIB-030USPR55. The method of claim 54, wherein the customized skin regimen comprises one or more of Hexapeptide- 2, Nonapeptide- 1 (Melanostatine), Decapeptide 12, Oligopeptide-34, Oligopeptide-51, or Tetrapeptide-30.

56. The method of claim 55, wherein the customized skin regimen comprises one or more of:(a) 0.6%-l% of Hexapeptide-2,(b) 5. l%-10% Nonapeptide-1 (Melanostatine),(c) 6.1%- 10% Decapeptide 12,(d) Oligopeptide-34,(e) Oligopeptide-51, and / or(f) 2%-5% Tetrapeptide-30.

57. The method of any one of claims 26-56, wherein the UV / Oxidative Damage / DNA / Cell damage category is moderate.

58. The method of claim 57, wherein the customized skin regimen comprises one or more of DAP tripeptide 33, Pepha-tight, ferulic acid, acetyl tetrapeptide-22 (Thermostressine), acetyl heptapeptide- 1, or tripeptide- 9 citrulline (dGlyage).

59. The method of claim 58, wherein the customized skin regimen comprises one or more of:(a) 0.5%- 1% DAP tripeptide 33,(b) 0. l%-0.5% Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan),(c) 0. l%-0.5% ferulic acid,(d) 2%-3% acetyl tetrapeptide-22 (Thermostressine),(e) 0.1%-5% acetyl heptapeptide- 1, and / or(f) 2%-3% tripeptide-9 citrulline (dGlyage).

60. The method of any one of claims 26-56, wherein the UV / Oxidative Damage / DNA / Cell damage category is severe.

61. The method of claim 60, wherein the customized skin regimen comprises one or more of DAP tripeptide 33, Pepha-tight, ferulic acid, acetyl tetrapeptide-22 (Thermostressine), acetyl heptapeptide- 1, or tripeptide-9 citrulline (dGlyage).

62. The method of claim 61, wherein the customized skin regimen comprises one or more of:(a) 1.1%-5% DAP tripeptide 33,(b) 0.6%- 1% Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan),(c) 0.6%- 1% ferulic acid,IPTS / 200163675.3 225Atorney Ref: VIB-030USPR(d) 3.1%-5% acetyl tetrapeptide-22 (Thermostressine),(e) 5.1%-10% acetyl heptapeptide- 1, and / or(f) 3. l%-5% tripeptide-9 citrulline (dGlyage).

63. The method of any one of claims 26-62, wherein the skin firming and elasticity category is moderate.

64. The method of claim 63, wherein the customized skin regimen comprises one or more of palmitoyl hexapeptide- 12 (Biopeptide EL), palmitoyl oligopeptide (Bio-bustyl), myristoyl pentapeptide- 8 (SymPeptide 222), palmitoyl oligopeptide (Biopeptide CL), acetyl heptapeptide 4 (Fensebiome), triptide- 10 citrulline (Decorinyl), hexapeptide- 10 (Serilesine), acetyl tetrapeptide- 11 (Syniorage), acetyl hexapeptide-38 (Adifyline), hexapeptide- 11 (Peptide Vinci 2), acetyl dipeptide- 13 diphenylglycine (Relistase), Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate), or acetyl tetrapeptide- 2 (Uplevity).

65. The method of claim 64, wherein the customized skin regimen comprises one or more of:(a) 3%-6% palmitoyl hexapeptide- 12 (Biopeptide EL),(b) 0.2%-0.5% palmitoyl oligopeptide (Bio-bustyl),(c) 0.01%-0.05% myristoyl pentapeptide- 8 (SymPeptide 222),(d) 0. l%-0.5% acetyl heptapeptide 4 (Fensebiome),(e) l%-3% triptide-10 citrulline (Decorinyl),(f) l%-5% hexapeptide- 10 (Serilesine),(g) 1350 ppm - 1500 ppm acetyl tetrapeptide- 11 (Syniorage),(h) 0.1%- 1% acetyl hexapeptide-38 (Adifyline),(i) 0.5%-l% hexapeptide- 11 (Peptide Vinci 2),(j) l%-2% acetyl dipeptide-13 diphenylglycine (Relistase),(k) 0.1%-0.5% Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxy butyrate), and / or(l) 0.1%- 1% acetyl tetrapeptide-2 (Uplevity).

66. The method of any one of claims 63-65, wherein the customized skin regimen comprises one or more of Pepha active, beta glucan, Bacillus extract, sea kelp extract, or alpaflor sebum.

67. The method of claim 66, wherein the customized skin regimen comprises one or more of:(a) l%-3% Pepha active,IPTS / 200163675.3 226Atorney Ref: VIB-030USPR(b) l%-3% beta glucan,(c) 0.5%-l% Bacillus extract,(d) 0.5%-l% sea kelp extract, and / or(e) 0.5%- 1% alpaflor sebum.

68. The method of any one of claims 63-67, wherein the customized skin regimen comprises one or more of D-Panthenol, magnesium ascorbyl phosphate, tocopherols, or niacinamide.

69. The method of claim 68, wherein the customized skin regimen comprises one or more of:(a) 0.5%-l% D-Panthenol,(b) 0.2%-l% magnesium ascorbyl phosphate,(c) 0.1% tocopherols, and / or(d) 0.1%-2% niacinamide.

70. The method of any one of claims 26-62, wherein the skin firming and elasticity category is severe.

71. The method of claim 70, wherein the customized skin regimen comprises one or more of palmitoyl hexapeptide- 12 (Biopeptide EL), palmitoyl oligopeptide (Bio-bustyl), myristoyl pentapeptide- 8 (SymPeptide 222), palmitoyl oligopeptide (Biopeptide CL), acetyl heptapeptide 4 (Fensebiome), triptide- 10 citrulline (Decorinyl), hexapeptide- 10 (Serilesine), acetyl tetrapeptide- 11 (Syniorage), acetyl hexapeptide-38 (Adifyline), hexapeptide- 11 (Peptide Vinci 2), acetyl dipeptide- 13 diphenylglycine (Relistase), Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate), or acetyl tetrapeptide- 2 (Uplevity).

72. The method of claim 71, wherein the customized skin regimen comprises one or more of:(a) 6.1%- 10% palmitoyl hexapeptide- 12 (Biopeptide EL),(b) 0.6%- 1% palmitoyl oligopeptide (Bio-bustyl),(c) 0.06%-0.1% myristoyl pentapeptide- 8 (SymPeptide 222),(d) 0.6%- 1% acetyl heptapeptide 4 (Fensebiome),(e) 3. l%-5% triptide-10 citrulline (Decorinyl),(f) 5.1%-10% hexapeptide- 10 (Serilesine),(g) acetyl tetrapeptide- 11 (Syniorage),(h) 1.1%-2% acetyl hexapeptide-38 (Adifyline),(i) 1.1%- 1.5% hexapeptide- 11 (Peptide Vinci 2),IPTS / 200163675.3 007Atorney Ref: VIB-030USPR(j) 2.1%-4% acetyl dipeptide-13 diphenylglycine (Relistase),(k) 0.6%-l% Syn-TacksSyn-Tacks (palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate), and / or(l) 1.1 % - 2 % acetyl tetrapeptide- 2 (U plevity ) .

73. The method of any one of claims 70-72, wherein the customized skin regimen comprises one or more of Pepha active, beta glucan, Bacillus extract, sea kelp extract, or alpaflor sebum.

74. The method of claim 73, wherein the customized skin regimen comprises one or more of:(a) 3. l%-5% Pepha active,(b) 3. l%-5% beta glucan,(c) l.l%-2% Bacillus extract,(d) l.l%-2% sea kelp extract, and / or(e) l%-2% alpaflor sebum.

75. The method of any one of claims 70-74, wherein the customized skin regimen comprises one or more of D-Panthenol, magnesium ascorbyl phosphate, tocopherols, or niacinamide.

76. The method of claim 75, wherein the customized skin regimen comprises one or more of:(a) l.l%-2% D-Panthenol,(b) 1.1%-2% magnesium ascorbyl phosphate,(c) 0.2% tocopherols, and / or(d) 2. l%-5% niacinamide.

77. The method of any one of claims 26-76, wherein the customized skin regimen comprises a peptide, wherein the peptide is one or more of Hexapeptide- 11, GHK-Cu, Palmitoyl Pentapeptide-4 (Pal-KTTKS), Palmitoyl Tetrapeptide-7 (Pal-GQPR), Dipeptide-2, Palmitoyl Pentapeptide-4, decapeptide- 12, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Acetyl Tetrapeptide-5, Heptapeptide-4, Acetyl Hexapeptide- 51 Amide, Acetyl Hexapeptide-30, Acetyl Hexapeptide-8 (Argireline), acetyl hexapeptide-3 (Argireline), Acetylarginyltryptophyl Diphenylglycine, Acetyl Hexapeptide-37, Hexapeptide- 10, Acetyl Octapeptide- 3, Tetrapeptide- 1, Tetrapeptide- 2, Acetyl Tetrapeptide-2, Acetyl Hexapeptide-38, Acetyl Dipeptide-3 Aminohexanoate, Tripeptide- 10 Citrulline (Decorinyl),IPTS / 200163675.3 228Atorney Ref: VIB-030USPRAcetyl Hexapeptide-49, Pentapeptide 18, Tripeptide 29, Nonapeptide- 1, Tripeptide 5, Palmitoyl Tripeptide-5, Diaminopropionoyl (DAP) Tripep tide-33, beta glucan, and / or bacillus extract.

78. The method of any one of claims 26-77, wherein the customized skin regimen comprises a retinoid, wherein the retinoid is one or more of retinol, retinal, tretinoin (retinoic acid), isotretinoin, alitretinoin, adapalene, bexarotene, tazarotene, and / or Trifarotene.

79. The method of any one of claims 26-78, wherein the customized skin regimen comprises an omega-3 fatty acid, wherein the omega-3 fatty acid is one or more of Alphalinolenic acid (ALA), Eicosapentaenoic acid (EPA), and / or Docosahexaenoic acid (DHA).

80. The method of any one of claims 26-79, wherein the customized skin regimen comprises an Alpha hydroxy acid, wherein the Alpha hydroxy acid is one or more of glycolic acid, lactic acid, mandelic acid, and / or citric acid.

81. The method of any one of claims 26-80, wherein a phenotypic parameter is wrinkles, Periorbital- around eyes (puffy eyes), Nasolabial folds (Laugh lines), worry lines, Uneven Skin tone / Pigmentation, and / or Age spots (Liver spots) and the customized skin regimen comprises one or more of Tretinoin, Zeaxanthin, Retinol, Retinoids, Vitamin C, Hyaluronic acid, Caffeine, Phytonadione, Vitamin E, Astaxanthin, Hyaluronic acid, Peptides, Niacinamide, Azelaic acid, Soybean extract, Kojic acid, Aloesin, and / or Turmeric.

82. The method of claim 85, further comprising one or more of Zeaxanthin, Collagen, Vitamin C, Resveratrol, Vitamin E, Vitamin C, Hyaluronic acid, Glutathione, Niacinamide, and / or Coenzyme Q10.

83. The method of any one of claims 26-82, wherein a skin questionnaire question is:(a) UV and the customized skin regimen comprises one or more of Zinc oxide, titanium oxide, Polypodium leucotomos, Vitamin E, Vitamin C, and / or Niacinamide;(b) Anti- wrinkling and the customized skin regimen comprises one or more of Tretinoin, Zeaxanthin, Retinol, Vitamin C, Hyaluronic acid, Collagen, Resveratrol, and / or Vitamin E;(c) Anti-pigmentation and the customized skin regimen comprises one or more of Niacinamide, Azelaic acid, Vitamin C, Soybean extract, Retinoids, Kojic acid, Vitamin E, Aloesin, Turmeric, and / or Glutathione(d) Moisturization and the customized skin regimen comprises one or more of Hyaluronic acid, Glycerin, Shea butter, Jojoba oil, Hyaluronan, Ceramides, and Collagen;IPTS / 200163675.3 229Atorney Ref: VIB-030USPR(e) Radiant complexion and the customized skin regimen comprises one or more of Vitamin C and / or Niacinamide,(f) Dry skin and the customized skin regimen comprises Glycerin;(g) Combinational skin and the customized skin regimen comprises Hyaluronic acid;(h) Acne-prone skin and the customized skin regimen comprises Benzoyl peroxide;(i) Sun exposure and the customized skin regimen comprises Zinc oxide and / or Titanium dioxide;(j) Sensitive skin - stinging or burning and the composition comprises Niacinamide(k) Sun and Humidity and the customized skin regimen comprises one or more of Vitamin E, Zinc oxide, Astaxanthin, and / or Omega-3 fatty acids(l) Wind and cold and the customized skin regimen comprises one or more of Petroleum jelly, Omega-3 fatty acids, and / or Probiotics.

84. The method of any one of claims 26-83, further comprising an excipient or carrier.

85. The method of claim 84, wherein the excipient or carrier is one or more of water, Caprylyl Glycol, butylene glycol, ultra low molecular weight (ulmw) hyaluronic acid, middle molecular weight (MMW) hyaluronic acid, and / or dimethyl isosorbide86. regimenhe method of any one of claims 26-85, wherein the customized skin regimen comprises one or more supplement or topical medication, or a supplement and a topical medication.

87. The method of claim 86, wherein the one or more topical medication and / or supplement comprise one or more of B-vitamins, Vitamin Bl, Vitamin B2, Vitamin B3, Vitamin B6, Vitamin B 12, vitamin C, vitamin D, vitamin E, vitamin F, peptides, retinoids, copper peptides, copper, zinc, collagen or collagen peptides, omega-3 fatty acids, hyaluronic acids, niacinamide, zinc, proline, glycine, vitamin E, alpha hydroxy acids, ginseng, green tea or green tea extract, capsaicin, zinc, probiotics, resveratrol, glycine, proline, green tea or green tea extract, silicon, niacinamide, silicon, vitamin A, aloe vera, Hydroquinone, Azelaic acid, Kojic acid, Cysteamine, Lignin peroxidase, Ellagic acid, L-Cystine, L-Glutathione, Polypodium leucotomos, Melatonin, Arbutin, Coenzyme Q10, Vitamin F, Kumazasa extract, Magnesium ascorbyl phosphate, Magnesium oil, ceramides, hyaluronan, procyanidin, probiotics, Galactooligosaccharides, Alpha-linolenic acid, Gamma-linolenic acid, Methylsulfonylmethane, Curcumin, Red ginseng, Aloe vera extract, Dexpanthenol, Polyphenols, Beta carotene, Flavanols, zinc, Lutein, Lycopene, Silymarin, Baicalin, Epigallocatechin gallate, Nicotinamide riboside, Nicotinamide mononucleotide, Zeaxanthin, Caffeine, Phytonadione, Astaxanthin, Soybean extract, Aloesin, Turmeric, Glycerin, SheaIPTS / 200163675.3 nonAtorney Ref: VIB-030USPR butter, Jojoba oil, Benzoyl peroxide, Conjugated Linoleic Acid, Berberine Extract, Quercetin, Calcium D-glucarate, Zinc oxide and / or Titanium dioxide.

88. The method of claim 87, wherein the peptide is one or more of Hexapeptide- 11, GHK-Cu, Palmitoyl Pentapeptide-4 (Pal-KTTKS), Palmitoyl Tetrapeptide-7 (Pal-GQPR), Dipeptide-2, Palmitoyl Pentapeptide-4, decapeptide- 12, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Acetyl Tetrapeptide-5, Heptapeptide-4, Acetyl Hexapeptide-51 Amide, Acetyl Hexapep tide-30, Acetyl Hexapeptide- 8 (Argireline), acetyl hexapeptide-3 (Argireline), Acetylarginyltryptophyl Diphenylglycine, Acetyl Hexapeptide-37, Hexapeptide- 10, Acetyl Octapeptide-3, Tetrapeptide- 1, Tetrapeptide- 2, Acetyl Tetrapeptide-2, Acetyl Hexapeptide-38, Acetyl Dipeptide-3 Aminohexanoate, Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide-49, Pentapeptide 18, Tripeptide 29, Nonapeptide- 1, Tripeptide 5, Palmitoyl Tripeptide-5, Diaminopropionoyl (DAP) Tripeptide- 33, beta glucan, and / or bacillus extract.

89. The method of claim 87 or 88, wherein the retinoid is one or more of retinol, retinal, tretinoin (retinoic acid), isotretinoin, alitretinoin, adapalene, bexarotene, tazarotene, and / or Trifarotene.

90. The method of any one of claims 87-89, wherein the omega-3 fatty acid is one or more of Alpha-linolenic acid (ALA), Eicosapentaenoic acid (EPA), and / or Docosahexaenoic acid (DHA).

91. The method of any one of claims 87-90, wherein the Alpha hydroxy acid is one or more of glycolic acid, lactic acid, mandelic acid, and / or citric acid.

92. The method of any one of claims 87-91, further comprising an excipient or carrier.

93. The method of claim 92, wherein the excipient or carrier is one or more of water, Caprylyl Glycol, butylene glycol, ultra low molecular weight (ulmw) hyaluronic acid, middle molecular weight (MMW) hyaluronic acid, and / or dimethyl isosorbide.

94. The method of any one of claims 26-93, wherein the customized skin regimen comprises any of the ingredients provided in Tables 9-32, and / or comprises the composition of Tables 9-32.

95. The method of any one of claims 26-94, wherein the customized skin regimen comprises:(a) Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- IPTS / 200163675.3 231Atorney Ref: VIB-030USPR38 (Adifyline), Acetyl Hexapeptide- 51 Amide (Juveleven™ Peptide Solution), Glycerin, Tripeptide-33 (DAP-Tripeptide-33), Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol, Ferulic Acid, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Panthenol, Copper Tripeptide- 1 (GHK-Cu), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Sunkiss), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (MMW Hyaluronic Acid), Pepha- tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3);(b) Water (aqua), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Decapeptide- 12, Nonapeptide- 1, Tripeptide-33 (DAP-Tripeptide-33), Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide- 10 Citrulline (Decorinyl), Hexapeptide- 11, Acetyl Octapeptide-3 (SNAP-8), PEG-16 Macadamia Glycerides, Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Sorbitol (Sorbitol 70), Acetyl Hexapeptide- 51 Amide (Juveleven™ Peptide Solution), Glycerin, Copper Tripeptide- 1 (GHK-Cu), Acetyl Tetrapeptide- 15, Butylene Glycol, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Dimethyl Isosorbide, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Allantoin, Sodium Hyaluronate (MMW Hyaluronic Acid), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3 / NP);(c) Water (aqua), Acetyl Hexapeptide-8 (Argireline), Nonapeptide- 1, AcetylHexapeptide- 30 (Inyline), Tripeptide- 10 Citrulline (Decorinyl), Acetyl Octapeptide-3 (SNAP-8), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), IPTS / 200163675.3 232Atorney Ref: VIB-030USPRHexapeptide- 11, Decapeptide- 12, Hexapeptide-49 (Delisens Solution), Decapeptide-4 (Reproage), Glycerin, Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide- 7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Tetrapeptide- 2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide- 5 Diaminobutyroyl Hydroxy threonine and Palmitoyl Dipeptide- 5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol, Palmitoyl Hexapeptide- 38 (Adifyline), Butylene Glycol, Dimethyl Isosorbide, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D- Panthenol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3);(d) Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Sorbitol, Nonapeptide- 1, Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Glycerin, Acetyl Hexapeptide-8 (Argireline), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide-2 (Uplevity), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low Molecular Weight), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Pentapeptide-3, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Sodium Phytate, Myristoyl Pentapeptide- 8;(e) Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide-10 Citrulline(Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, IPTS / 200163675.3 233Atorney Ref: VIB-030USPRNonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha- tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide-2 (Uplevity), Parfum (Fragrance), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low Molecular Weight), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Sodium Phytate, Myristoyl Pentapeptide- 8;(f) Water (aqua), Acetyl Tetrapeptide- 5 (Eyeseryl), Tripeptide- 10 Citrulline (Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha- tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide-2 (Uplevity), Parfum (Fragrance), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low Molecular Weight), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Sodium Phytate, Myristoyl Pentapeptide- 8;(g) Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide- 10 Citrulline(Decorinyl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl IPTS / 200163675.3 234Atorney Ref: VIB-030USPRHomophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Pentapeptide-4, Dipeptide-2, Magnesium Ascorbyl Phosphate, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha- tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide-2 (Uplevity), Parfum (Fragrance), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex), Sodium Phytate;(h) Water (aqua), Tripeptide- 10 Citrulline (Decorinyl), Acetyl Tetrapeptide-5 (Eyeseryl), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin, Nonapeptide- 1, Magnesium Ascorbyl Phosphate, Acetyl Hexapeptide-30 (Inyline), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide-2 (Uplevity), Parfum (Fragrance), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Clearthix S (Algin and Cellulose Gum), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Poly aery late Crosspolymer-6 (Seppic SepiZen), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT- GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex), Sodium Phytate, Myristoyl Pentapeptide- 8;(i) Water (aqua), Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Tripeptide-10Citrulline (Decorinyl), Acetyl Hexapeptide-8 (Argireline), Acetyl Octapeptide-3 (SNAP-8), Glycerin, Hexapeptide-11, Decapeptide- 12, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl IPTS / 200163675.3 235Atorney Ref: VIB-030USPRTetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), PEG- 16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide- 5 (Eyeseryl), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide- 5 Diaminobutyroyl Hydroxy threonine and Palmitoyl Dipeptide- 5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Palmitoyl Pentapeptide-38, Butylene Glycol, Dimethyl Isosorbide, Acetyl Hexapeptide- 38 (Adifyline), Tripeptide-33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK- Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate, Ceramide NP (Ceramide 3 / NP);(j) Water (aqua), Inyline (Tripeptide- 1 and Palmitoyl Tripeptide- 1 and Palmitoyl Tetrapeptide-7 and Acetyl Dipeptide- 1 Cetyl Ester, Nonapeptide- 1, Acetyl Hexapeptide-30), Hexapeptide-49 (Delisens), Tripeptide-10 Citrulline (Decorinyl), Acetyl Octapeptide-3 (SNAP-8), Hexapeptide- 11, Glycerin, Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, PEG- 16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide- 5 (Eyeseryl), Sorbitol (Sorbitol 70), Butylene Glycol, Dimethyl Isosorbide, Magnesium Ascorbyl Phosphate, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Tripeptide-33 (DAP- Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Clearthix S (Algin and Cellulose Gum), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Caffeine,IPTS / 200163675.3 236Atorney Ref: VIB-030USPRCeramide NP (Ceramide 3 / NP), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate;(k) Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Acetyl Hexapeptide- 51 Amide (Juveleven™ Peptide Solution), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Tripeptide-33 (DAP- Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin Methyl Chaicone, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Ferulic Acid, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP);(l) Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Tripeptide-33 (DAP- Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin Methyl Chaicone, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Ferulic Acid, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP);IPTS / 200163675.3 237Atorney Ref: VIB-030USPR(m) Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Tripeptide-33 (DAP- Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Ferulic Acid, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP);(n) Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Acetyl Hexapeptide- 38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Glycerin, Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Arginine / Lysine Polypeptide, Tripeptide-33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D- Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP), Ferulic Acid;(o) Water (aqua), Nonapeptide- 1, Hexapeptide-49, Palmitoyl Tetrapeptide-7,Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, Glycerin, Acetyl IPTS / 200163675.3 238Atorney Ref: VIB-030USPRHexapeptide- 38 (Adifyline), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Butylene Glycol, Dimethyl Isosorbide, Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Sorbitol (Sorbitol 70), Oligopeptide- 10, Tripeptide-33 (DAP-Tripeptide-33), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Copper Tripeptide- 1 (GHK-Cu), Hesperidin, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Niacinamide, Allantoin, Caffeine, Clearthix S (Algin and Cellulose Gum), Sodium Hyaluronate (Medium Molecular Weight), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), HydroxyethylAcrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ceramide NP (Ceramide 3 / NP), Ferulic Acid;(p) Water (aqua), Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide-8 (Argeriline), Acetyl Octapeptide-3 (SNAP-8), Glycerin, Hexapeptide-11, Decapeptide- 12, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), PEG- 16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide- 5 (Eyeseryl), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide- 5 Diaminobutyroyl Hydroxy threonine and Palmitoyl Dipeptide- 5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Palmitoyl Pentapeptide-38, Butylene Glycol, Dimethyl Isosorbide, Hydroxypropyl Tetrahydropyrantriol (Proxylane), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Acetyl Hexapeptide- 38 (Adifyline), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl- 6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin andIPTS / 200163675.3 239Atorney Ref: VIB-030USPRCellulose Gum), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate, Ceramide NP (Ceramide 3 / NP);(q) Water (aqua), Acetyl Hexapeptide-8 (Argireline), Nonapeptide- 1, Acetyl Hexapeptide- 30 (Inyline), Tripeptide- 10 Citrulline (Decorinyl), Glycerin, Acetyl Octapeptide-3 (SNAP-8), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn- Ake), Hexapeptide- 11, Decapeptide- 12, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Hydroxypropyl Tetrahydropyrantriol (Proxylane), Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide- 5 (Eyeseryl), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Palmitoyl Pentapeptide-38, Acetyl Hexapeptide- 38 (Adifyline), Butylene Glycol, Dimethyl Isosorbide, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3 / NP);(r) Water (aqua), Acetyl Tetrapeptide- 5 (Eyeseryl), Sorbitol (Sorbitol 70),Nonapeptide- 1, Tripeptide-10 Citrulline (Decorinyl), Acetyl Hexapeptide- 30 (Inyline Solution), Glycerin, Acetyl Hexapeptide-8 (Argireline), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Decapeptide- 4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Tetrapeptide-2 (Uplevity), Hexapeptide- 10 (Sirulisene), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene IPTS / 200163675.3 -) / inAtorney Ref: VIB-030USPRGlycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Oligopeptide- 10, Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Poly glyceryl- 6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Myristoyl Pentapeptide- 8;(s) Water (aqua), Palmitoyl Tripeptide- 1 (Decorinyl), Argirelox (Acetyl Hexapeptide- 8 and Pentapeptide- 18), Glycerin, Acetyl Tetrapeptide-5 (Eyeseryl), Acetyl Hexapeptide- 30 (Inyline), Nonapeptide- 1, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Acetyl Octapeptide-3 (SNAP-8), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide- 5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Pentapeptide-4, Dipeptide- 2, Magnesium Ascorbyl Phosphate, Decapeptide-4 (Reproage), Tetrapeptide- 2 (Uplevity), Tetrapep tide-30, Macrocystis Pyrifera (Kelp) Extract, Panthenol (D- Panthenol), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Parfum (Fragrance), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT- GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Phytate, Ceramide NP (Ceramide 3 / NP);(t) Water (aqua), Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Glycerin,Tripeptide-10 Citrulline (Decorinyl), Nonapeptide- 1, Acetyl Hexapeptide-30 (Inyline), Acetyl Tetrapeptide-5 (Eyeseryl), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Dipeptide-2, Decapeptide-4 (Reproage), Macrocystis Pyrifera (Kelp) Extract, Pepha- tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D- Panthenol), Tetrapeptide-2 (Uplevity), Parfum (Fragrance), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Magnesium Ascorbyl Phosphate, Hexapeptide- 11, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl IPTS / 200163675.3 241Atorney Ref: VIB-030USPRChaicone, Caffeine, Ferulic Acid, Clearthix S (Algin and Cellulose Gum), Sodium Phytate, Myristoyl Pentapeptide- 8;(u) Water (aqua), Acetyl Tetrapeptide-5 (Eyeseryl), Glycerin, Nonapeptide- 1, Argirelox (Acetyl Hexapeptide-8 and Pentapeptide- 18), Hexapeptide-49,Tetrapep tide-30, Tripeptide-10 Citrulline (Decorinyl), Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (Syn-Up), Palmitoyl Tetrapeptide-7, Dipeptide-2, Magnesium Ascorbyl Phosphate, Syn-Eye (Palmitoyl Tripeptide-5 and Panthenol and Sodium Hyaluronate and Dunaliella Salina Extract and Pentylene Glycol and Citric Acid), Tripeptide-33 (DAP-Tripeptide-33), Macrocystis Pyrifera (Kelp) Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Acetyl Tetrapeptide- 15, Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Panthenol (D-Panthenol), Decapeptide-4 (Reproage peptide), Tetrapeptide- 2 (Uplevity), Palmitoyl Pentapeptide-4, Parfum (Fragrance), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Ferulic Acid, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Sodium Hyaluronate (Ultra Low + Middle Molecular Weight Hyaluronic Acid Powder), Ahnfeltiopsis concinna Extract (APT-GPF), Butylene Glycol, Dimethyl Isosorbide, Hesperidin Methyl Chaicone, Caffeine, Ammonium Acryloyldimethyltaurate / VP Copolymer (Aristoflex), Allantoin, Clearthix S (Algin and Cellulose Gum), Sodium Phytate;(v) Water (aqua), Acetyl Hexapeptide-8 (Argeriline), Acetyl Hexapeptide- 30 (Inyline), Tripeptide-10 Citrulline (Decorinyl), Glycerin, Acetyl Octapeptide-3 (SNAP-8), Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), Palmitoyl Tripeptide-5, Decapeptide- 12, Palmitoyl Tripep tide-38, Hexapeptide-49 (Delisens), Decapeptide-4 (Reproage), Nonapeptide- 1, Palmitoyl Pentapeptide-4, Dipeptide-2, PEG- 16 Macadamia Glycerides, Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide-29, Hexapeptide- 11, Tripeptide-33 (DAP-Tripeptide-33), Acetyl Tetrapeptide- 15, Sorbitol (Sorbitol 70), Tetrapeptide-2 (Uplevity), Acetyl Hexapeptide- 38 (Adifyline), Butylene Glycol, Dimethyl Isosorbide, Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Copper Tripeptide- 1 (GHK- Cu), Syn-TacksSyn-Tacks (Palmitoyl Dipeptide-5 DiaminobutyroylHydroxy threonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Naturesolv (Caprylyl / Capryl IPTS / 200163675.3 242Atorney Ref: VIB-030USPRGlucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl- 6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Niacinamide, Caffeine, Clearthix S (Algin and Cellulose Gum), Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer (Sepinov), Ferulic Acid, Sodium Phytate, Ceramide NP (Ceramide 3 / NP);(w) Water (aqua), Decorinyl (Tripeptide- 1 and Palmitoyl Tripeptide- 1 and Palmitoyl Tetrapeptide-7 and Acetyl Dipeptide-1 Cetyl Ester, Tripeptide-10 Citrulline), Hexapeptide-49 (Delisens Solution), Acetyl Hexapeptide- 30 (Inyline), Hexapeptide - 11, Acetyl Octapeptide-3 (SNAP-8), Nonapeptide- 1, Palmitoyl Tripeptide-5, Dipeptide-2, Acetyl Tetrapeptide- 15, Tetrapeptide-2 (Uplevity), PEG- 16 Macadamia Glycerides, Hydroxypropyl Tetrahydropyrantriol (Proxylane), Parfum (Fragrance), Acetyl Tetrapeptide-5 (Eyeseryl), Tripeptide-29, Palmitoyl Pentapeptide-4, Tripeptide-33 (DAP-Tripeptide-33), Sorbitol (Sorbitol 70), Glycerin, Decapeptide-4 (Reproage), Butylene Glycol, Dimethyl Isosorbide, Magnesium Ascorbyl Phosphate, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D-Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Pepha-tight (Nannochloropsis Oculata (Algae) Extract and Pullulan), Copper Tripeptide- 1 (GHK-Cu), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Caffeine, Ceramide NP (Ceramide 3 / NP), Ferulic Acid, Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate; or(x) Water (aqua), Inyline (Tripeptide- 1 and Palmitoyl Tripeptide- 1 and PalmitoylTetrapeptide-7 and Acetyl Dipeptide-1 Cetyl Ester, Nonapeptide- 1, Acetyl Hexapeptide-30), Hexapeptide-49 (Delisens), Tripeptide-10 Citrulline (Decorinyl), Acetyl Octapeptide-3 (SNAP-8), Hexapeptide- 11, Glycerin, Decapeptide-4 (Reproage), Tripeptide-29, Palmitoyl Tripeptide-5, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Tetrapeptide- 15, PEG- 16 Macadamia Glycerides, Tetrapeptide-2 (Uplevity), Acetyl Tetrapeptide-5 (Eyeseryl), Sorbitol (Sorbitol 70), Oligopeptide- 10, Butylene Glycol, Dimethyl Isosorbide, Magnesium Ascorbyl Phosphate, Polyacrylate Crosspolymer-6 (Seppic SepiZen), Beta-Glucan, Bacillus Ferment (Bacillus Extract), Alpaflor Sebum (Epilobium Fleischeri Flower / Leaf / Stem Extract), Panthenol (D- Panthenol), Plantaserve E (Ethylhexylglycerin and Phenoxyethanol), Tripeptide-33 (DAP-Tripeptide-33), Copper Tripeptide- 1 (GHK-Cu), Pepha-tight (Nannochloropsis IPTS / 200163675.3 243Atorney Ref: VIB-030USPROculata (Algae) Extract and Pullulan), Clearthix S (Algin and Cellulose Gum), Naturesolv (Caprylyl / Capryl Glucoside, Sodium Cocoyl Glutamate, Glyceryl Caprylate, Citric Acid, Polyglyceryl-6 Oleate, and Sodium Surfactin), Parfum (Fragrance), Allantoin, Sodium Hyaluronate (Medium Molecular Weight), Caffeine, Ceramide NP (Ceramide 3 / NP), Ferulic Acid, Hydroxyethyl Acrylate / S odium Acryloyldimethyl Taurate Copolymer (Sepinov), Sodium Phytate.

96. The method of any one of claims 1 and 3-95, further comprising additionally administering the customized skin regimen one or more times to the subject.

97. The method of claim 96, wherein the customized skin regimen is additionally administered one or more times to the subject without re-determining the customized skin regimen.

98. A customized skin regimen, wherein the customized skin regimen is determined according to a method of any one of claims 2-95.IPTS / 200163675.3 244

Images