A mixing container for parenteral nutrition

Abstract

A mixing container for parenteral nutrition Described herein is a blow molded mixing container for parenteral nutrition. The mixing container comprises a container body having a first compartment and a second compartment separated by a first partition wall. The first compartment stores a first medical liquid and the second compartment stores a second medical liquid. The mixing container comprises a pierceable lid for sealing the first compartment and the second compartment towards a proximal end of the mixing container body. The mixing container further comprises a closure assembly mounted at the proximal end of the mixing container body. The closure assembly comprises a first piercing member and a second piercing member configured to puncture the pierceable lid. A mixing space for mixing the first medical liquid and the second medical liquid for parenteral nutrition is provided between the pierceable lid and the closure assembly. The closure assembly is movable from an initial first position, in which the pierceable lid is intact, to a second position, in which the first piercing member and the second piercing member puncture the pierceable lid allowing the flowing of the first liquid and the second liquid into the mixing space.

Description

[0001] Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0002] A mixing container for parenteral nutrition

[0003] Field of invention

[0004] The invention relates to a mixing container for storing and mixing liquid constituents to form parenteral nutrition.

[0005] Background of the invention

[0006] Liquid constituents for parenteral nutrition typically comprise fat, glucose and amino acids. There are known compounders for mixing parenteral nutrition. Such compounders can mix individual compositions of parenteral nutrition. However, such devices can only be operated economically if large amounts of parenteral nutrition are needed at the location of the compounder.

[0007] However, it is generally not possible to store a liquid comprising all these three constituents already mixed for a longer period. Therefore, it is desired to store the constituents separately and they are mixed when the parenteral nutrition is required to be administered or infused to the patient.

[0008] However, mixing of the liquids for infusion requires an external mixing system and the administration of the mixed liquid becomes cumbersome.

[0009] Patent application WO 2006 / 010411 Al (patent applicant: Fresenius Kabi Deutschland GmbH) describes a muti-chamber-concept in which the constituents are stored in one bag having several chambers or compartments and wherein the chambers are separated by peelable seals. Each constituent is stored in one separated chamber of the bag. In detail it is presented a 3-chamber-bag having parenteral nutrition constituents of glucose solution, amino acid solution and lipid emulsion stored individually in separated chambers. Prior to patient administration, pressure is applied on the bag, for instance by rolling the bag, to open the peelable seals and to enable mixing of the constituents. The mixed parenteral nutrition is administered to the patient.

[0010] Summary of the Invention

[0011] It is an object of the present invention to provide an alternative portable and compact container system for storing liquid constituents for parenteral nutrition. Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0012] It is another object of the present invention to enable mixing of the liquid constituents to form parenteral nutrition in a simple and efficient manner.

[0013] The aforesaid objects are achieved by the solution provided in claim 1 of the present invention. Various embodiments of the invention are subject of the dependent claims, of the description and of the drawings.

[0014] Accordingly, the present invention generally discloses a mixing container comprising a container body having at least a first compartment and a second compartment separated by a first partition wall. The first compartment stores a first liquid and the second compartment stores a second liquid. The mixing container comprises a pierceable lid for sealing the first compartment and the second compartment towards a proximal end of the container body. A closure assembly is mounted at the proximal end of the container body. The closure assembly comprises a first piercing member and a second piercing member configured to puncture the pierceable lid. A mixing space for mixing the first liquid and the second liquid is provided between the pierceable lid and the closure assembly. The closure assembly is movable from an initial first position, in which the pierceable lid is closed or intact respectively, to a second position, in which the first piercing member and the second piercing member puncture the pierceable lid allowing the flow and / or mixing of the first liquid and the second liquid into the mixing space. Upon puncturing of the pierceable lid, the first piercing member is received in the first compartment comprising the first liquid and the second piercing member is received in the second compartment comprising the second liquid. In an embodiment, the first liquid and the second liquid comprise amino acids, glucose and / or fat.

[0015] The present invention claims a mixing container for parenteral nutrition, comprising : a container body having a first compartment for storing a first parenteral nutrition liquid and a second compartment for storing a second parenteral nutrition liquid, wherein the first compartment stores a first liquid and the second compartment stores a second liquid; a pierceable lid for sealing the first compartment and the second compartment towards a proximal end of the container body; a closure assembly mounted at the proximal end of the container body, wherein the closure assembly comprises a first piercing member and a second piercing member configured to puncture the pierceable lid; a mixing space for mixing the first liquid and the second liquid for parenteral nutrition is provided between the pierceable lid and the closure assembly, Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO wherein the closure assembly is movable from an initial first position, in which the pierceable lid is closed / intact, to a second position, in which the first piercing member and the second piercing member puncture the pierceable lid allowing the mixing / flow of the first liquid and the second liquid into the mixing space.

[0016] The container of the present invention is preferably embodied as a bottle, in particular as a bottle for medical or parenteral nutrition. Preferably the container is a container made of plastic. One example for a plastic material comprises polyolefin, as for instance polyethylene (PE), in particular low-density-polyethylene (LDPE) and / or polypropylene (PP).

[0017] Preferably the container is a blow molded container. In one example the bottle is a BFS- bottle. This is a bottle which is produced by Blow-Fill-Seal method (BFS). In another example the bottle is a SBM-bottle. This is a bottle which is produced by Stretch-Blow- Molding method (SBM).

[0018] In an embodiment, the container body comprises a first compartment, a second compartment and a third compartment for storing a third parenteral nutrition liquid. The first compartment preferably stores a first liquid, the second compartment stores a second liquid and the third compartment stores a third liquid. In an embodiment, the first liquid, the second liquid and the third liquid comprise amino acids, glucose and / or fat respectively. In this embodiment, the container body comprises the first partition wall separating the first compartment and the second compartment and at least a second partition wall separating the second compartment and the third compartment.

[0019] According to one embodiment, the first compartment, the second compartment and / or the third compartment extend longitudinally, substantially throughout the length of the mixing container. Preferably, the first partition wall and / or the second partition wall extend substantially throughout the length of mixing container.

[0020] In an embodiment, the closure assembly comprises a first piercing member, a second piercing member and a third piercing member configured to be received in the first compartment, the second compartment and the third compartment respectively upon puncturing of the pierceable lid. The piercing members are selected from a needle, knife, spike or any other suitable piercing member known in the art. The first piercing member, the second piercing member and / or the third piercing member are positioned slightly above the pierceable lid in the initial first position of the closure assembly. The first piercing member is assigned to the first compartment, the second piercing member is assigned to Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO the second compartment and / or the third piercing member is assigned to the third compartment. Preferably the first piercing member pierces and opens the lid section of the first compartment, the second piercing member pierces and opens the lid section of the second compartment and / or the third piercing member pierces and opens the lid section of the third compartment.

[0021] The closure assembly preferably further comprises an adapter mounted on the proximal end of the container body and a cap secured on a top portion of the adapter. The first piercing member, the second piercing member and / or the third piercing member are preferably affixed to a head portion of the cap and protrude in a downward direction. According to one embodiment, the first piercing member, the second piercing member and / or the third piercing member are mounted to a lower side of the adapter and / or to a lower side of the cap and protrude in a downward direction.

[0022] The cap comprises a cap body and at least one connecting device that is arranged on the cap body. The cap body, on a top surface, preferably comprises two connecting devices for connecting various conveying devices during an infusion. The connecting devices each comprise a sealing element which is received in a holding device in the form of a positive locking holder on the cap body and is held in a clamping manner on the holding device. The sealing elements serve the purpose of closing openings on the top surface of the cap body to the outside. The connecting devices are connectable to the corresponding conveying devices which are able to be positioned against an outside surface of the sealing element. The connecting devices preferably are each covered by a break-off part in an initial state and are closed to the outside in such a manner that the openings with the sealing elements, arranged therein are not accessible from the outside and are protected against contamination. The interior formed by the break-off parts is preferably sterile. The break-off parts are connected to the cap body at a predetermined breaking point such that the break-off part detaches from the cap body along the predetermined breaking point. A possible embodiment of the cap is described in patent application WO 2018 / 060333 Al. The content of this patent application concerning the construction and function of the cap is incorporated herein by reference.

[0023] In one embodiment, the closure assembly further comprises a tamper evident member towards the proximal end of the container body. The tamper evident member is configured to be removed before puncturing of the pierceable lid. In this embodiment, the tamper evident member is configured as a ring or ring member, preferably covering the outer side of the adapter. Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0024] In one further embodiment, the adapter comprises an upper portion and a lower portion. The upper portion and the lower portion of the adapter in particular are frusto-conical shaped. The adapter comprises a fold line passing through the junction of the upper portion and the lower portion. The tamper evident member is preferably configured as a cover within the closure assembly.

[0025] In an embodiment, the cap is pushed from a top or a top surface to move the closure assembly to the second position such that the first piercing member, the second piercing member and / or the third piercing member move axially downward. The upper portion and the lower portion of the adapter are configured to be folded about the fold line to allow axial downward movement of the closure assembly including the first piercing member, the second piercing member and / or the third piercing member.

[0026] The aforementioned construction of the adapter is not limiting with respect to the present invention. A person skilled in the art would appreciate that the adapter can have any other suitable construction and shape known in the art to allow the folding of the adapter when the cap is pushed in a downward direction. For example, the adapter can have an accordion like body which allows folding of the adapter when the cap is pushed in a downward direction.

[0027] In another embodiment of the present invention, the adapter comprises a large diameter lower portion and a small diameter upper portion such that a diameter of the adapter gradually transitions from large diameter to a small diameter in an upward direction. A middle portion of the adapter comprises continuous transition of diameter. Said middle portion is, preferably, uniformly curved and comprises continuous variable diameter. The adapter is shaped as a type of funnel. The adapter is mounted on the proximal end of the container body by coupling the lower portion with the proximal end of the container body.

[0028] The cap is mounted on the upper portion of the adapter. According to the present embodiment, the tamper evident member is configured as a ring. Said ring is positioned proximal to a bottom surface of the adapter in the first initial position of the closure assembly. The closure assembly is preferably rotated and moved axially in a downward direction to the second position of the closure assembly. The adapter of the closure assembly is preferably coupled to the container body through a threaded engagement. Upon rotating the closure assembly, the closure assembly also moves in an axial downward direction. In this embodiment, the first piercing member, the second piercing member and / or the third piercing member are affixed to the adapter and protrude in a downward direction from the adapter. The piercing members are also selected from a needle, knife, Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO spike or any other suitable piercing member known in the art. The tamper evident ring is positioned to rest on an outer shoulder of the container body in an initial first position of the closure assembly. In other words, the tamper evident member is sandwiched between the bottom surface of the adapter and the outer shoulder. Said outer shoulder is formed towards the proximal end of the container body.

[0029] In an embodiment, the adapter of the closure assembly is coupled to the container body through complementary thread formation. Complementary threads are formed on an outer surface, towards the proximal end, of the container body and an inner surface of lower portion of the adapter. Thus, upon rotating the closure assembly, the closure assembly also moves in an axial direction. In an embodiment, a clockwise direction rotation of the closure assembly results in a downward motion of the closure assembly and an anticlockwise direction rotation of the closure assembly results in an upward motion of the closure assembly. The closure assembly is preferably rotated in a clockwise direction to move the closure assembly to the second position. In the second position of the closure assembly, the first piercing member, the second piercing member and / or the third piercing member puncture the pierceable lid. The first liquid, the second liquid and / or the third liquid from the first compartment, the second compartment and / or the third compartment flow into the mixing space upon puncturing of the pierceable lid. Said liquids mix with each other in the mixing space to form the parenteral nutrition. Said parenteral nutrition is accessible for infusion through the cap.

[0030] In one embodiment of the container body, the first compartment, the second compartment and / or the third compartment of the container body are sandwiched. Preferably, the first partition wall and the second partition wall are substantially parallel to each other. The first partition wall and the second partition wall form three elongated chambers within the container body. In said configuration, the second, here middle, compartment is sandwiched between the first compartment and the third compartment of the container body.

[0031] In one further embodiment of the container body, the first compartment, the second compartment and / or the third compartment are concentric. Preferably, the first partition wall and the second partition wall are concentric as well.

[0032] In one further embodiment of the container body, the first compartment, the second compartment and / or the third compartment form circular sectors. The compartments form a type of cake pieces. Preferably, the first partition wall, the second partition wall and / or the third partition wall are joined along their longitudinal axis to form a star-shaped cross Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO section. The first partition wall, the second partition wall and the third partition wall form the first compartment, the second compartment and the third compartment.

[0033] In an embodiment, the container body of the mixing container is produced from a preform using stretch blow molding process. The preform for stretch blow molding process comprises a first compartment and a second compartment separated by a first partition wall of the preform.

[0034] In an embodiment, the preform comprises a first compartment, a second compartment and a third compartment. The preform comprises a first partition wall and a second partition wall. The first partition wall separates the first compartment and the second compartment of the preform. The second partition wall separates the second compartment and the third compartment of the preform. In said configuration, the second compartment is sandwiched between the first compartment and the third compartment.

[0035] In another embodiment, the preform comprises a first partition wall, a second partition wall and a third partition wall. The first partition wall, the second partition wall and the third partition wall are joined along their longitudinal axis to form a star-shaped cross section. The first compartment, the second compartment and / or the third compartment of the container body are or form circular sectors.

[0036] In one further embodiment of the preform, the first compartment, the second compartment and / or the third compartment form concentric sectors. The first compartment, the second compartment and / or the third compartment are formed by a first partition wall and a second partition. The first partition wall and the second partition wall are concentric.

[0037] The first partition wall, the second partition wall and / or the third partition wall of the preform magnify or transform respectively into the first partition wall, the second partition wall and / or the third partition wall of the container body upon production of the mixing container using stretch blow molding process. Accordingly, the first compartment, the second compartment and / or the third compartment of the preform magnify or transform respectively into the first compartment, the second compartment and / or the third compartment of the container body upon production of the mixing container using stretch blow molding.

[0038] In an alternative embodiment, the container body of the mixing container is produced using blow fill seal process. In this case the mixing container comprises a, preferably Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO cylindrical, container body. According to the process, a plastic resin is heated and extruded to form a tube comprising an outer wall of the container body, a first partition wall and preferably a second partition wall for a 3-compartment design. The outer wall, the first partition wall and / or the second partition wall are concentric. The outer wall, the first partition wall and / or the second partition wall of the tube form a first compartment, a second compartment and / or a third compartment. The first compartment, the second compartment and the third compartment of the tube are concentric.

[0039] Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0040] Brief description of drawings

[0041] The idea underlying the invention shall be explained in greater detail below with reference to the illustrative embodiments represented in the figures, wherein:

[0042] Figure l.a illustrates a side view, for instance a front view, of a mixing container in upside-down configuration according to a first embodiment of the present invention;

[0043] Figure l.b illustrates on the left side a perspective view of a preform for production of the container body of the mixing container as shown in Figure l.a (without a closure assembly) and on the right side a perspective sectional view of the container body of the mixing container shown in figure l.a and produced from the preform (shown on the left side);

[0044] Figure l.c illustrates a side view, for instance a front view, of the mixing container as shown in figure l.a with the closure assembly in a first upper position (left side) in which the mixing container is still closed and with the closure assembly in a second lower position (right side) in which the mixing container is opened,

[0045] Figures l.d illustrates a corresponding cross-sectional view of the closure assembly shown in figure l.c in a first upper position (left side) in which the mixing container is still closed and in a second lower position (right side) in which the mixing container is opened.

[0046] Figure 2. a illustrates a side view, for instance a front view, of a mixing container in upside-down configuration according to a second embodiment of the present invention;

[0047] Figure 2.b illustrates on the left side a perspective view of a preform for production of the container body of the mixing container as shown in Figure 2. a (without a closure assembly) and on the right side a perspective sectional view of the container body of the mixing container shown in figure 2. a and produced from the preform (shown on the left side);

[0048] Figure 2.c illustrates a side view, for instance a front view, of the mixing container shown in figure 2. a with the closure assembly in a first upper position (left side) in which the mixing container is still closed and with the closure device in a second lower position (right side) in which the mixing container is opened.

[0049] Figures 2.d illustrates a corresponding cross-sectional view of the closure assembly shown in figure 2.c in a first upper position (left side) in which the mixing container is still closed and in a second lower position (right side) in which the mixing container is opened. Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0050] Figure 3. a illustrates a side view, for instance a front view, of a mixing container in upside-down configuration according to a third embodiment of the present invention;

[0051] Figure 3.b illustrates on the left side a perspective view of a preform for production of the container body of the mixing container as shown in Figure 3. a (without a closure assembly) and on the right side a perspective sectional view of the container body of the mixing container shown in figure 3. a and produced from the preform (shown on the left side).

[0052] Figure 4. a illustrates a side view, for instance a front view, of an upside-down mixing container according to a fourth embodiment of the present invention.

[0053] Figure 4.b illustrates a cross-sectional view of the mixing container according to Figure 4. a.

[0054] Figure 4.c illustrates a perspective sectional view of container body of the mixing container according to Figure 4. a (with the closure assembly in a pre-assembled state).

[0055] Figures 4.d illustrates a cross sectional view of the closure assembly shown in figure 4. a in a first upper position in which the mixing container is still closed.

[0056] Figures 4.e illustrates a cross sectional view of the closure assembly shown in figure 4. a in a second lower position in which the mixing container is opened.

[0057] Detailed description of drawings

[0058] Figure l.a shows a side view, for instance a front view, of a mixing container 100 in an upside-down configuration for storing liquid constituents of parenteral nutrition separately. The mixing container 100 comprises a container body 112 having a plurality of compartments 102, 104, 106 for storing respective different, preferably liquid, constituents of parenteral nutrition. The mixing container 100 comprises a closure assembly 200 mounted at a proximal end 108 of the container body 112. The closure assembly 200 is mounted on a neck portion 120 of the container body 112.

[0059] Figure l.b (left side) shows a preform 110 used to produce the container body 112 of the mixing container 100 shown in figure l.a through stretch blow molding process. The preform 110 comprises preferably an essentially cylindrical or conical body 112'. The preform 110 comprises a plurality of partition walls 114', 116', 118' fixedly joined to each Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO other along a central longitudinal axis of the preform 110. The partition walls 114', 116', 118' extend substantially throughout the length of the preform 110. Said plurality of partition walls 114', 116', 118' form a plurality of compartments 102', 104', 106' of the preform 110. At the bottom of the preform body 112' a hanger 140 is positioned. This hanger 140 is used to hang the later produced container 100 in upside down orientation, for instance to a rack, for patient infusion.

[0060] In the shown embodiment, the preform 110 comprises three partition walls 114', 116', 118' fixedly joined to each other along a central longitudinal axis of the preform 110. In the presented example the three partition walls 114', 116', 118' are joined such that they are positioned substantially at an angle of 120 degree from each other. Said shown three partition walls 114', 116', 118' form three compartments 102', 104', 106' such that the three compartments preferably have equal volumes. The formed compartments 102', 104', 106' are embodied as circular sectors or so-called cake pieces. The size of the compartments 102', 104', 106' is chosen dependent on the required volume of each parenteral nutrition constituents. Accordingly, the compartments 102', 104', 106' can have different volumes as well (not shown in the figures). The preform 110 is for instance produced by injection molding.

[0061] Figure l.b (right side) shows the interior of the container body 112 produced from the preform 110 using stretch blow molding process shown on the left side of figure l.b. The preform 110 undergoes stretch blow molding process such that the plurality of partition walls 114', 116', 118' transform into a plurality of partition walls 114, 116, 118 of the container body 112. Furthermore, the plurality of compartments 102', 104', 106' of the preform 110 transform into the plurality of compartments 102, 104, 106 of the container body 112. The formed compartments 102, 104, 106 take the form of the preform 110. The formed compartments 102, 104, 106 of this embodiment take the form of cake pieces or, even if the formed container body 112 is not circular, are embodied or formed as essentially circular sectors.

[0062] In the shown embodiment, the container body 112 comprises three compartments 102, 104, 106. Said compartments 102, 104, 106 include, as an example, a first liquid, a second liquid and a third liquid. Preferably, the first liquid comprises amino acids, the second liquid comprises glucose and the third liquid comprises fat.

[0063] Figure l.c illustrates a side view, for instance a front view, of the container 100 shown in figure l.a with the closure assembly 200 in a first upper position (left side) in which the Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO container 100 is still closed and in a second lower position (right side) in which the container 100 is opened.

[0064] Figure l.d illustrates a corresponding cross-sectional view of the closure assembly 200 shown in figure l.c in a first upper position (left side) in which the container 100 is still closed (position 1) and in a second lower position (right side) in which the container 100 is opened (position 2).

[0065] The closure assembly 200 comprises a cap 202. In the illustrated embodiment, the cap 202 comprises a cap body 204 which, on a top surface, comprises two connecting devices 208, 210 for connecting various conveying devices (not shown) during an infusion or for injection an additive into the container. The connecting devices 208, 210 each comprise a sealing element which is received in a holding device in the form of a positive locking holder on the cap body 204 and is held in a clamping manner on the holding device (not shown in the figures). The sealing elements serve the purpose of closing openings on the top surface of the cap body 204 to the outside. The connecting devices 208, 210 are connectable to the corresponding conveying devices which are able to be positioned against an outside surface of the sealing element. The connecting devices 208, 210 are each covered by a break-off part 224, 226 in an initial state, and are closed to the outside in such a manner that the openings with the sealing elements arranged therein are not accessible from the outside and are protected against contamination. The interior formed by the break-off parts 224, 226 is preferably sterile. The break-off parts 224, 226 are connected to the cap body 204 at a predetermined breaking point such that the break-off part detaches from the cap body 204 along the predetermined breaking point. Arrows in the break-off parts 224 and 226 identify the ports as a port 208 for infusion (left side) and as a port 210 for injection (right side). A possible embodiment of the cap 202 (without piercing members) is described in patent application WO 2018 / 060333 Al (patent applicant: Fresenius Kabi Deutschland GmbH). The content of this patent application concerning the construction and function of the cap is incorporated herein by reference.

[0066] The closure assembly 200 further comprises a plurality of piercing members 228, 230, 232 such that the piercing members 228, 230, 232 are affixed to a head portion of the cap 202 and protrude in a downward direction. The plurality of piercing members 228, 230, 232 are configured to puncture a pierceable lid 236 of the mixing container 100. The pierceable lid 236 is provided at a top end of the compartments 102, 104, 106 for sealing the plurality of compartments 102, 104, 106. As an example, the pierceable lid 236 is a thin plastic layer of foil. The pierceable lid 236 is fixed to the container body 112 after Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO filling. For instance, the pierceable lid 236 can be fixed to the top end of the container body 112 by gluing or welding.

[0067] The plurality of piercing members 228, 230, 232 are positioned slightly above the pierceable lid 236 in an initial first position of the closure assembly 200. A mixing space 150 for mixing the first liquid, the second liquid and the third liquid for parenteral nutrition is provided between the pierceable lid 236 and the closure assembly 200. The mixing space 150 is the space where the parenteral nutrition constituents are merging. It is not necessary that the entire mixing or the mixing as such takes place in the mixing space 150.

[0068] In the present embodiment, the closure assembly 200 comprises three piercing members 228, 230, 232 corresponding to the three compartments 102, 104, 106. The piercing members 228, 230, 232 are selected from a needle, knife, spike or any other suitable piercing member known in the art. In the shown example the fat emulsion is assigned to the first compartment 102, the glucose solution is assigned to the second compartment 104 and the amino acid solution is assigned to the third compartment 106. A different liquid distribution can be applied as well.

[0069] The closure assembly 200 comprises an adapter 238 mounted on the proximal end, preferably the neck portion 120, of the container body 112. The adapter 238 comprises an upper portion 240 and a lower portion 242. The shown upper portion 240 and the lower portion 242 of the adapter 238 are frusto-conical shaped. The adapter 238 comprises a fold line 244 passing through the junction of the upper portion 240 and the lower portion 242.

[0070] The closure assembly 200 further comprises a tamper evident member 227 towards the proximal end of the container body 112. The tamper evident member 227 is configured as a cover within the closure assembly 200. The tamper evident member 227 is positioned above the pierceable lid 236 in an initial first position of the closure assembly 200. The tamper evident member 227 is embodied as a ring covering the adapter 238.

[0071] In the initial first position of the closure assembly 200 as shown in the left side of Figure l.d, the pierceable lid 236 is closed or still intact. The tamper evident member 227 is configured as a cover and is positioned within the closure assembly 200, preferably along the fold line 244 of the adapter 238 according to the embodiment shown in Figures l.d (left side). The tamper evident member 227 is intact in the first position of the closure assembly 200 accordingly. Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0072] In operation, the cap 202 is pushed from a top surface to move the closure assembly 200 from the first position to the second position after removing the tamper evident member 227 (right figure in Figure l.d). The plurality of piercing members 228, 230, 232 moves axially downward when the closure assembly 200 moves from the first position to the second position. To allow said downward movement of the closure assembly 200 and the plurality of piercing members 228, 230, 232, the upper portion 240 and the lower portion 242 of the adapter 238 are configured to be folded about the fold line 244. When said downward movement of the closure assembly 200 is initiated, the upper portion 240 and the lower portion 242 are folded, preferably, in a vertical direction along the fold line 244 such that an outer edge of the upper portion 240 at least partially overlaps with an outer edge of the lower portion 242. The closure assembly 200 moves to the second position such that the upper portion 240 and the lower portion 242 of the adapter 238 are folded along the fold line 244.

[0073] The aforementioned construction of the adapter 238 is not limiting with respect to the present invention. A person skilled in the art would appreciate that the adapter can have any other suitable construction and shape known in the art to allow the folding of the adapter when the cap 202 is pushed in a downward direction. For example, the adapter can have an accordion like body which allows folding of the adapter when the cap is pushed in a downward direction.

[0074] In the second position of the closure assembly 200, the plurality of piercing members 228, 230, 232 puncture the pierceable lid 236. The plurality of liquids from the plurality of compartments 102, 104, 106 flow into the mixing space 150 upon puncturing of the pierceable lid 236. The liquids mix with each other for instance in the mixing space 150 to form the parenteral nutrition. Said parenteral nutrition is accessible for infusion through the cap 202.

[0075] The piercing members 228, 230, 232 are positioned in accordance with the position of the compartments 102, 104, 106. In the shown embodiment, the closure assembly 200 comprises three piercing members 228, 230, 232 corresponding to the three compartments 102, 104, 106. Each of the three piercing members 228, 230, 232 is positioned axially above a corresponding compartment from the three compartments 102, 104, 106. Each of the three piercing members punctures the pierceable lid 236 and enters the corresponding compartment from the three compartments 102, 104, 106. Each of the three compartments 102, 104, 106 of the mixing container 100 contains the first liquid, the second liquid and the third liquid respectively. Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0076] Figures 2. a to 2.d show a second embodiment of a mixing container 300. The compartments and therefore also the piercing members are arranged in a different configuration. The following description focuses on the differences. For same or similar features, it is referred to the previous description of figures l.a to l.d.

[0077] Figure 2. a illustrates a side view, for instance a front view, of an upside-down mixing container 300 according to second embodiment of the present invention. The mixing container 300 is configured to store liquid constituents of parenteral nutrition separately. The mixing container 300 comprises a container body 312 having a plurality of compartments 302, 304, 306 for storing respective different liquid constituents of parenteral nutrition. The mixing container 300 comprises a closure assembly 400 mounted at a proximal end 308 of the container body 312. Preferably, the closure assembly 400 is mounted on a neck portion 320 of the container body 312.

[0078] Figure 2.b (left side) shows a preform 310 used to produce the container body 312 of the mixing container 300 through stretch blow molding process. The preform 310 comprises preferably an essentially cylindrical or conical body 312'. The preform 310 comprises a plurality of partition walls 314', 316' extending substantially throughout the length of the preform 310. Said plurality of partition walls 314', 316' form a plurality of compartments 302', 304', 306' of the preform 310. In the shown embodiment, the preform 310 comprises two partition walls 314', 316' positioned essentially parallel to each other. Said two partition walls 314', 316' form three sandwiched compartments 302', 304', 306'. In addition, the preform 310 comprises on a bottom side a hanger 340.

[0079] Figure 2.b (right side) shows the container body 312 produced from the preform 310 using stretch blow molding process. The preform 310 undergoes stretch blow molding process such that the plurality of partition walls 314', 316', transform into a plurality of partition walls 314, 316 of the container body 312. Furthermore, the plurality of compartments 302', 304', 306' of the preform 310 transform into the plurality of compartments 302, 304, 306 of the container body 312. In the shown embodiment, the container body 312 comprises three compartments 302, 304, 306. The compartment 304 is sandwiched between the compartments 302 and 306. Said compartments 302, 304, 306 include a first liquid, a second liquid and a third liquid. Preferably, the first liquid comprises amino acids, the second liquid comprises glucose and / or the third liquid comprises fat.

[0080] Figure 2.c illustrates a side view, for instance a front view, of the container 300 shown in figure 2. a with the closure assembly 400 in a first upper position (left side) in which the Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO container 300 is still closed and in a second lower position (right side) in which the container 300 is opened.

[0081] Figures 2.d illustrates a cross sectional view of the closure assembly 400 shown in figure 2. a in a first upper position (left side - position 1) in which the container 300 is still closed and in a second lower position (right side - position 2) in which the container 400 is opened. The closure assembly 400 comprises a cap 402. Preferably, the cap 402 has the same configuration as the aforementioned cap 202 except that the piercing members are differently positioned due to the different compartment position. In the shown example the fat emulsion is assigned to the first compartment 302, the glucose solution is assigned to the second compartment 304 and the amino acid solution is assigned to the third compartment 306. A different liquid distribution can be applied as well.

[0082] The closure assembly 400 comprises a plurality of piercing members 428, 430, 432 such that the piercing members 428, 430, 432 are preferably affixed to a head portion of the cap 402 and protrude in a downward direction. The piercing members 428, 430, 432 are positioned in accordance with the position of the compartments 302, 304, 306 being in a sandwiched configuration. The piercing members 428, 430, 432 are preferably arranged in a row. A mixing space 250 for mixing the first liquid, the second liquid and the third liquid for parenteral nutrition is provided between the pierceable lid 436 and the closure assembly 400.

[0083] Figures 3. a and to 3.b show a third embodiment of a mixing container 500. The compartments and therefore also the piercing members are arranged in a different configuration. The following description focuses on the differences. For same or similar features, it is referred to the previous description of figures l.a to l.d related to the first embodiment and to the previous description of figures 2. a to 2.d related to the second embodiment.

[0084] Figure 3. a shows a side view, for instance a front view, of a mixing container 500 in an upside-down configuration for storing liquid constituents of parenteral nutrition separately. The mixing container 500 comprises a container body 512 having a plurality of concentric compartments 502, 504, 506 for storing respective different liquid constituents of parenteral nutrition. The mixing container 500 comprises a closure assembly 600 mounted at a proximal end 508 of the container body 512. Preferably, the closure assembly 600 is mounted on a neck portion 520 of the container body 512. The closure assembly 600 can also comprises a tamper evident member as shown for the previous embodiments but is not shown in the present figure. Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0085] Figure 3.b (left side) shows a preform 510 used to produce the container body 512 of the mixing container 500 through stretch blow molding process. The preform 510 comprises preferably an essentially cylindrical or conical body 512'. The preform 510 comprises a plurality of partition walls 514', 516' extending substantially throughout the length of the preform 510. Said plurality of partition walls 514', 516' form a plurality of concentric compartments 502', 504', 506' of the preform 510. In addition, the preform 510 comprises on a bottom side a hanger 540.

[0086] Figure 3.b (right side) shows the container body 512 produced from the preform 510 using stretch blow molding process. The preform 510 undergoes stretch blow molding process such that the plurality of partition walls 514', 516' transform into a plurality of partition walls 514, 516 of the container body 512. Furthermore, the plurality of compartments 502', 504', 506' of the preform 510 transform into the plurality of compartments 502, 504, 506 of the container body 512.

[0087] The closure assembly 600 comprises also a cap 602 and an adapter 638.

[0088] In one embodiment the closure assembly 600 is configured the same or similar with the closure assembly 200 as used in the first embodiment (shown in figures l.a to l.d) or similar with the closure assembly 400 as used in the second embodiment (shown in figures 2. a to 2.d). The position of three piercing members (not shown in the figures) is adapted to the position of the three concentric compartments 502, 504 and 506. The piercing members are positioned at different radial positions. For instance, the piercing members are positioned in a row on the same radius.

[0089] In another embodiment, the closure assembly 600 is configured similar with the closure assembly 800 as used in the fourth embodiment. This fourth embodiment is described in the subsequent description and shown in the corresponding figures 4.d and 4.e.

[0090] Figure 4. a to 4.c illustrate a mixing container 700 according to a fourth embodiment of the present invention. The mixing container 700 is configured to store liquid constituents of parenteral nutrition separately. The mixing container 700 comprises a plurality of compartments 702, 704, 706 for storing respective different liquid constituents of parenteral nutrition. The mixing container 700 comprises a container body 712 and closure assembly 800 mounted at a proximal end 708 of the container body 712. In one embodiment (not shown in the figures), the closure assembly 800 is mounted on a neck portion of the container body 712. Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0091] In the shown embodiment, the container body 712 is produced using blow-fill seal (BFS) manufacturing technique. In that, a plastic resin is heated and extruded to form a tube / parison. The extruded tube comprises a plurality of concentric partition walls (not shown). The extruded tube is then enclosed in a mold and the tube is cut above the mold. In the next step the extruded plastic tube is inflated to form the container body 712 within the mold. In the next step the formed container body 712, i.e. the formed compartments 702, 704, 706 of the container body 712, is / are filled via the open top side with the desired plurality of liquids. This process is or can be followed by sealing the top side of the container body 712. The excess portion of the formed seal is removed by cutting. A thin membrane remains or can remain closing the top of the blown, filled and sealed container body 712. Preferably the thin membrane provides the pierceable lid 736. Thereafter, the molded mixing container body 712 is discharged and the closure assembly 800 is mounted with the container body 712.

[0092] In the shown embodiment, the container body 712 includes three concentric compartments 702, 704, 706. Said three concentric compartments are formed by two concentric partition walls 714, 716.

[0093] Figure 4.d shows a cross-sectional view of the closure assembly 800 in the upper position in which the container 700 is still closed (position 1). The closure assembly 800 comprises a cap 802. In a preferred embodiment, the cap 802 is the same or similar with the aforementioned cap 202. A possible embodiment of the cap is described in patent application WO 2018 / 060333 Al. The content of this patent application concerning the construction and function of the cap is incorporated herein by reference.

[0094] The closure assembly 800 further comprises an adapter 838 mounted on the proximal end of the container body 712. The adapter 838 comprises a lower large diameter lower portion 840 and an upper small diameter upper portion 842 such that a diameter of the adapter 838 preferably gradually transitions from large diameter to a small diameter in an upward direction. A middle portion 841 of the adapter 838 comprises a preferably continuous transition of diameter. Said middle portion 841 is, preferably, uniformly curved and comprises continuous variable diameter. The adapter 838 is mounted on the proximal end of the container body 712 by coupling the lower portion 840 with the proximal end. The cap 802 is mounted on the upper portion 842 of the adapter 838. The adapter 838 is essentially funnel-type. Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0095] The closure assembly 800 further comprises a plurality of piercing members 828, 830, 832 such that the piercing members 828, 830, 832 are affixed to the adapter 838 and protrude in a downward direction from the adapter 838. The plurality of piercing members 828, 830, 832 are, preferably, formed on the middle portion 841 of the adapter 838. The plurality of piercing members 828, 830, 832 are configured to puncture the pierceable lid 736.

[0096] The position of three piercing members 828, 830, 832 is adapted to the position of the three concentric compartments 702, 704, 706. The piercing members 828, 830, 832 are positioned at different radial positions. In the shown embodiment, the piercing members 828, 830, 832 are exemplary positioned in a row on the same radius. The pierceable lid 736 is preferably provided by the BFS production process and provided at a top end of the compartments 702, 704, 706 for sealing the plurality of compartments 702, 704, 706. The lid 736 can also be provided as a separate component and fixed to the container body 712 as for instance disclosed for the first embodiment of the present invention. The plurality of piercing members 828, 830, 832 are positioned slightly above the pierceable lid 736 in an initial first position of the closure assembly 800. A mixing space 350 for mixing the first liquid, the second liquid and the third liquid for parenteral nutrition is provided at least between the pierceable lid 736 and the closure assembly 800. In the shown example the fat emulsion is assigned to the first compartment 702, the amino acid solution is assigned to the second compartment 704 and the glucose solution is assigned to the third compartment 706. A different liquid distribution can be applied as well.

[0097] The closure assembly 800 further comprises a tamper evident member 827 towards the proximal end of the container body 712. The tamper evident member 827 is configured as a ring. Said ring is positioned proximal to a bottom surface of the adapter 838 in the first initial position of the closure assembly 800. Said tamper evident member 827 is positioned to rest on an outer shoulder 746 of the container body 712 in an initial first position of the closure assembly 800. In other words, the tamper evident member 827 is sandwiched between the bottom surface of the adapter 838 and the outer shoulder 746. Said outer shoulder 746 is formed towards the proximal end of the container body 712.

[0098] Figure 4.e illustrates another cross sectional view of the closure assembly 800 in a second lower position thereof. In the initial first position of the closure assembly 800 as shown in Figure 4.d, the pierceable lid 736 is closed and intact. The tamper evident member 827 is intact in the first position of the closure assembly 800. In operation, after removing the tamper evident member 827, the closure assembly 800 is here rotated and moved axially in a downward direction to the second position of the closure assembly 800 (position 2). Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0099] The adapter 838 of the closure assembly 800 is preferably coupled to the container body 712 through a threaded engagement. Complementary threads 748 are formed on an outer surface, towards the proximal end, of the container body 712 and an inner surface of lower portion 840 of the adapter 838. Thus, upon rotating the closure assembly 800, the closure assembly 800 also moves in an axial direction. In an embodiment, a clockwise direction rotation of the closure assembly 800 results in a downward motion of the closure assembly 800 and an anti-clockwise direction rotation of the closure assembly 800 results in an upward motion of the closure assembly 800. The closure assembly 800 is rotated in a clockwise direction to move the closure assembly 800 to the second position. In the second position of the closure assembly 800, the plurality of piercing members 828, 830, 832 puncture the pierceable lid 736. The plurality of liquids from the plurality of compartments 702, 704, 706 flow into the mixing space 350 upon puncturing of the pierceable lid 736. The liquids mix with each other in the mixing space 350 to form the parenteral nutrition. Said parenteral nutrition is accessible for infusion through the cap 802.

[0100] It will be understood that the invention may be embodied in other specific forms without departing from the spirit or central characteristics thereof. The present examples and embodiments, therefore, are to be considered in all respects as illustrative and not restrictive, and the invention is not to be limited to the details given herein. Accordingly, features of the above-described specific embodiments can be combined with one another. Further, features described in the summary of the invention can be combined with one another. Furthermore, features of the above-described specific embodiments and features described in the summary of the invention can be combined with one another.

[0101] Reference numbers:

[0102] 100 Mixing container (fist embodiment):

[0103] 102 First compartment

[0104] 104 Second compartment

[0105] 106 Third compartment

[0106] 108 Proximal end

[0107] 112 Container body

[0108] 114 First partition wall

[0109] 116 Second partition wall

[0110] 118 Third partition wall

[0111] 120 Neck portion Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0112] 110 Preform

[0113] 102' First preform compartment

[0114] 104' Second preform compartment

[0115] 106' Third preform compartment

[0116] 112' Preform body

[0117] 114' First preform partition wall

[0118] 116' Second preform partition wall

[0119] 118' Third preform partition wall

[0120] 140 Hanger

[0121] 150 Mixing space

[0122] 200 Closure assembly

[0123] 202 Cap

[0124] 204 Cap body

[0125] 208 Connecting device or infusion port

[0126] 210 Connecting device or injection port

[0127] 224 Break-off part

[0128] 226 Break-off part

[0129] 227 Tamper evident member

[0130] 228 First piercing member

[0131] 230 Second piercing member

[0132] 232 Third piercing member

[0133] 236 Pierceable lid

[0134] 238 Adapter

[0135] 240 Upper adapter portion

[0136] 242 Lower adapter portion

[0137] 244 Adapter fold line

[0138] 300 Mixing container (second embodimentj :

[0139] 302 First compartment

[0140] 304 Second compartment

[0141] 306 Third compartment

[0142] 308 Proximal end Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0143] 312 Container body

[0144] 314 First partition wall

[0145] 316 Second partition wall

[0146] 320 Neck portion

[0147] 310 Preform

[0148] 302' First preform compartment

[0149] 304' Second preform compartment

[0150] 306' Third preform compartment

[0151] 312' Preform body

[0152] 314' First preform partition wall

[0153] 316' Second preform partition wall

[0154] 340 Hanger

[0155] 250 Mixing space

[0156] 400 Closure assembly

[0157] 402 Cap

[0158] 404 Cap body

[0159] 408 Connecting device or infusion port

[0160] 410 Connecting device or injection port

[0161] 424 Break-off part

[0162] 426 Break-off part

[0163] 427 Tamper evident member

[0164] 428 First piercing member

[0165] 430 Second piercing member

[0166] 432 Third piercing member

[0167] 436 Pierceable lid

[0168] 438 Adapter

[0169] 440 Upper adapter portion

[0170] 442 Lower adapter portion

[0171] 444 Adapter fold line

[0172] 500 Mixing container (third embodiment):

[0173] 502 First compartment Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0174] 504 Second compartment

[0175] 506 Third compartment

[0176] 508 Proximal end

[0177] 512 Container body

[0178] 514 First partition wall

[0179] 516 Second partition wall

[0180] 520 Neck portion

[0181] 510 Preform

[0182] 502' First preform compartment

[0183] 504' Second preform compartment

[0184] 506' Third preform compartment

[0185] 512' Preform body

[0186] 514' First preform partition wall

[0187] 516' Second preform partition wall

[0188] 540 Hanger

[0189] 250 Mixing space

[0190] 600 Closure assembly

[0191] 602 Cap

[0192] 638 Adapter

[0193] 700 Mixing container (fourth embodiment') :

[0194] 702 First compartment

[0195] 704 Second compartment

[0196] 706 Third compartment

[0197] 708 Proximal end

[0198] 712 Container body

[0199] 714 First partition wall

[0200] 716 Second partition wall

[0201] 736 Pierceable lid

[0202] 746 Outer shoulder

[0203] 748 Thread or threaded engagement

[0204] 350 Mixing space Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO

[0205] 800 Closure assembly

[0206] 802 Cap

[0207] 838 Adapter

[0208] 840 Adapter lower large diameter portion

[0209] 841 Adapter middle portion

[0210] 842 Adapter upper small diameter portion

[0211] 827 Tamper evident member

[0212] 828 First piercing member

[0213] 830 Second piercing member

[0214] 832 Third piercing member

Claims

Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WOClaims1. A blow molded mixing container (100, 300, 500, 700) for parenteral nutrition, comprising : a container body (112, 312, 512, 712) having a first compartment (102, 302, 502, 702) for storing a first parenteral nutrition liquid and a second compartment (104, 304, 504, 704) for storing a second parenteral nutrition liquid; a pierceable lid (236, 436, 636, 836) for sealing the first compartment (102, 302, 502, 702) and the second compartment (104, 304, 504, 704) towards a proximal end (108, 308, 508, 708) of the container body (112, 312, 512, 712); a closure assembly (200, 400, 600, 800) mounted at the proximal end (108, 308, 508, 708) of the container body (112, 312, 512, 712), wherein the closure assembly (200, 400, 600, 800) comprises a first piercing member (228, 428, 628, 828) and a second piercing member (230, 430, 630, 830) configured to puncture the pierceable lid (236, 436, 636, 836); a mixing space (150, 250, 350) for mixing the first liquid and the second liquid for parenteral nutrition between the pierceable lid (236, 436, 636, 836) and the closure assembly (200, 400, 600, 800), wherein the closure assembly (200, 400, 600, 800) is movable from an initial first position, in which the pierceable lid (236, 436, 636, 836) is intact, to a second position, in which the first piercing member (228, 428, 628, 828) and the second piercing member (230, 430, 630, 830) puncture the pierceable lid (236, 436, 636, 836) allowing the flow of the first liquid and the second liquid into the mixing space (150, 250, 350).

2. The mixing container (100, 300, 500, 700) according to claim 1, wherein the container body (112, 312, 512, 712) comprises a third compartment (106, 306, 506, 706) for storing a third parenteral nutrition liquid and the closure assembly (200, 400, 600, 800) comprises a third piercing member (232, 432, 632, 832) configured to puncture the pierceable lid (236, 436, 636, 836).25Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO3. The mixing container (100, 300, 500, 700) according to one of the preceding claims, wherein the first compartment (102, 302, 502, 702), the second compartment (104, 304, 504, 704) and / or the third compartment (106, 306, 506, 706) extend longitudinally and substantially throughout the length of the container body (112, 312, 512, 712).

4. The mixing container (100, 300, 500, 700) according to one of the preceding claims, wherein, upon puncturing of the pierceable lid (236, 436, 636, 836), the first piercing member (228, 428, 628, 828) is received in the first compartment, the second piercing member (230, 430, 630, 830) is received in the second compartment (104, 304, 504, 704) and / or the third piercing member (232, 432, 632, 832) is received in the third compartment (106, 306, 506, 706).

5. The mixing container (100, 300, 500, 700) according to one of the preceding claims, wherein the closure assembly (200, 400, 600, 800) comprises an adapter (238, 438, 638) mounted on the proximal end (108, 308, 508, 708) of the container body (112, 312, 512, 712) and a cap (202, 402, 602, 802) secured on a top portion of the adapter (238, 438, 638).

6. The mixing container (100, 300, 500, 700) according to one of the preceding claims, wherein a tamper evident member (227, 427, 827) is provided, in particular towards the proximal end (108, 308, 508, 708) of the container body (112, 312, 512, 712), the tamper evident member (227, 427, 827) is configured to be removed before puncturing of the pierceable lid (236, 436, 636, 836).

7. The mixing container (100, 300, 500, 700) according to one of the preceding claims, wherein the tamper evident member (227, 427, 827) is configured as a removable ring member within the closure assembly (200, 400, 600, 800).

8. The mixing container (100, 300, 500, 700) according to one of the preceding claims, wherein the first piercing member (228, 428, 628, 828), the second piercing member (230, 430, 630, 830) and / or the third piercing member (232, 432, 632, 832) are mounted to a lower side of the adapter (238, 438, 638) and / or to a lower side of the cap (202, 402, 602, 802) and protrude in a downward direction.

9. The mixing container (100, 300, 500, 700) according to one of the preceding claims, wherein the cap (202, 402, 602, 802) is pushed from a top surface toFresenius Kabi Deutschland GmbH FK19102-03-PAT-WO move the closure assembly (200, 400, 600, 800) to the second position such that the first piercing member (228, 428, 628, 828), the second piercing member (230, 430, 630, 830) and / or the third piercing member (232, 432, 632, 832) move axially downward.

10. The mixing container (100, 300, 500) according to one of the preceding claims, wherein the adapter (238, 438) comprises an upper portion (240, 440), a lower portion (242, 442) and a fold line (244, 444) passing through a junction of the upper portion (240, 440) and the lower portion (242, 442) wherein the upper portion (240, 440) and the lower portion (242, 442) of the adapter (238, 438) are configured to be folded about the fold line (244, 444) to allow axial downward movement of the closure assembly (200, 400, 600).

11. The mixing container (700) according to one of the preceding claims, wherein the closure assembly (800) is rotated and moved axially in a downward direction to the second position of the closure assembly (800).

12. The mixing container (700) according to one of the preceding claims, wherein the adapter (838) of the closure assembly (800) is coupled to the container body (712) through a threaded engagement (748).

13. The mixing container (300) according to one of the preceding claims, wherein the first compartment (302), the second compartment (304) and / or the third compartment (306) of the container body (312) are sandwiched.

14. The mixing container (500) according to one of the preceding claims, wherein the first compartment (502), the second compartment (504) and / or the third compartment (506) of the container body (512) are concentric.

15. The mixing container (100) according to one of the preceding claims, wherein the first compartment (102), the second compartment (104) and / or the third compartment (106) of the container body (112) form circular sectors.

16. The mixing container (100, 300, 500, 700) according to one of the preceding claims, wherein the first liquid comprises amino acid, the second liquid comprises glucose and / or the third liquid comprises fat.Fresenius Kabi Deutschland GmbH FK19102-03-PAT-WO17. The mixing container (100, 300, 500, 700) according to one of the preceding claims, wherein the mixing container (700) is produced by a blow-fill-seal (BFS) process or the mixing container (100, 300, 500) is produced from a preform (110, 310, 510) using stretch blow molding (SBM) process.

18. Preform (110, 310, 510) for stretch blow molding a mixing container according to one of the preceding claims, comprising at least a first compartment, a second compartment and preferably a third compartment.

19. The preform (110, 310, 510) according to the preceding claim wherein the first compartment, the second compartment and preferably the third compartment of the container body are sandwiched or concentric or form circular sectors.28

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