A polydopamine-containing dental removable prosthesis adhesive

Abstract

The present invention relates to a removable prosthesis adhesive which provides for the enhancement of retention in dental removable prostheses.

Description

[0001] DESCRIPTION

[0002] A POLYDOPAMINE-CONTAINING DENTAL REMOVABLE

[0003] PROSTHESIS ADHESIVE

[0004] Technical Field

[0005] The present invention relates to a removable prosthesis adhesive which provides for the enhancement of retention in dental removable prostheses.

[0006] Prior Art

[0007] In complete dentures, retention is the resistance of the prosthesis to forces acting opposite to the path of insertion, which are generally in a perpendicular direction. Anatomical, physical, and mechanical factors play a role in retention.

[0008] 1. Anatomical Factors:

[0009] The width of the alveolar arch, the ridge form, tuberosities, frena, tori, the retromolar pad (for retention in the mandible, 2 / 3 of the retromolar pad should be covered by the prosthesis; therefore, the entire retromolar pad must be captured in the impression), teeth, mucosal thickness, and the shape of the palate determine the anatomical factors. Additionally, the buccal shelf and the mylohyoid ridge play an important role in retention.

[0010] The presence, amount, and location of undercuts, and the rotational paths of insertion obtained by utilizing them, are important for prosthesis retention.

[0011] 2. Physical Factors:

[0012] Adhesion is the attraction between the dissimilar molecules of two different bodies whose surfaces are in contact. Adhesion prevents the prosthesis from dislodging in a vertical direction. However, if horizontal forces are applied, the prosthesis dislodges more easily. Primary adhesion can develop when a pressure impression is taken. In other words, the dentures are retentive during function, but the retention is compromised at rest.

[0013] Cohesion is the electrical attraction between like molecules. In other words, it is the force that binds the molecules of a substance to each other. Viscous, mucin-rich mucous saliva is more cohesive than serous saliva. Cohesive forces also ensure the continuity of the salivary film. In complete dentures, the cohesive effect of saliva also aids in adhesion.

[0014] Interfacial forces are the resistance to separation of two parallel surfaces that have a layer of liquid film between them.

[0015] Surface Tension of Saliva (Capillarity, Meniscus): This is the unidirectional molecular attraction that occurs at a surface. It is effective in cases where the peripheral seal is good. Capillary attraction occurs as a result of the thin space between the intaglio surface of the prosthesis and the mucosal surface acting like a capillary tube, which forms a meniscus

[0016] Viscosity of Saliva: It is the resistance of saliva to flow. This becomes important when the denture base tends to be displaced. However, viscosity beyond a certain limit also adversely affects retention.

[0017] Atmospheric Pressure and Peripheral Seal: This is effective when the denture borders are well sealed, similar to the principle in the Torricelli experiment (covering a glass full of water with paper and inverting it).

[0018] Gravity: This is important for the retention of mandibular (lower) dentures.

[0019] 3. Mechanical Factors:

[0020] The peripheral seal (post dam area), suction, adhesives, balanced occlusion, clasps, the neutral zone, and polished surfaces (Fish stated that contouring the polished surfaces of the prosthesis to achieve maximum contact with the surrounding orofacial muscles leads to a significant increase in retention; in other words, the muscles of the face and mouth are also important for retention)1, neuromuscular control, magnets, and microvalves.

[0021] The AH Line and Post-Dam Area: In complete dentures, or in cases where the base plate of a removable partial denture extends to the posterior region of the maxilla, the aim is to prevent air from entering under the denture base by having the plate slightly compress the tissues in this area.

[0022] For this purpose, the tissue resilience in this region must be evaluated very carefully. Physiologically, it is the junction between the movable and immovable parts of the palate. This region moves when the patient makes an “AH” sound. The clinician identifies this intraorally, transfers it to the model, and the model is then carved along this line to a depth of approximately 1 mm. As a result of this carving process, the finished prosthesis will have a raised bead in the vibrating line (AH line) region, corresponding to the amount that was carved.

[0023] In fact, for finishing the posterior border of the prosthesis, the preparation of the post-dam area is a more correct approach than the method mentioned above. The post-dam area is an addition to the tissue surface of maxillary dentures. Its purpose is to protect the prosthesis against the disruption of the peripheral seal under functional stresses; that is, to prevent air from leaking under the denture base from its posterior border and, consequently, compromising its retention. Another benefit of its preparation is that it compensates for the potential distortion of the posterior part of the maxillary denture that occurs during the polymerization of the acrylic. The width of the post-dam area is, on average, approximately 1.5 mm in the hamular notch region, 5 mm between the midline and the notch, and 2-3 mm in the midline section. The depth of the post-dam area, on the other hand, should be prepared to an average of 1 mm in the center and 1.5 mm towards the lateral aspects. The postdam area can be obtained by the clinician using a direct intraoral method; that is, after a zinc oxide eugenol impression is taken, a special No. 4 Korekta wax is placed on the posterior border of the impression, which is then seated in the patient's mouth and shaped by the patient's functional movements. Alternatively, the area can be identified by the clinician intraorally using a round-tipped instrument and then transferred to the model; in other words, it can be determined by an indirect method. Recently, with the use of light-cured acrylics, this area can also be added to the finished prosthesis intraorally.

[0024] The posterior border of the prosthesis must be on the vibrating line, but it must always be on immovable tissues.

[0025] In complete dentures, stabilization is provided by the tooth arrangement, balanced occlusion, balanced articulation, and selective grinding. The polished surfaces of the prosthesis and the neutral zone are also of great importance for stabilization.

[0026] There are three main types of denture adhesives: powder, cream, and cushion forms. In recent years, liquid forms have also become available.

[0027] However, the cream and powder forms are the most commonly used. Currently, synthetic materials are the most preferred.

[0028] The most popular and successful products are short-acting salt mixtures (such as Carboxymethylcellulose or CMC) and long-acting polymers like polyvinyl methyl ether-maleate or Gantrez. (Example: Calcium / Zinc PVM / MA Copolymer (33%), Paraffinum Liquidum, Cellulose Gum (20%), Petrolatum, Silica, Menthyl Lactate, CI 14720, Aroma, Menthol, CI 16185, Limonene).

[0029] In the presence of water, CMC hydrates and rapidly forms ionic bonds with both the prosthesis and the mucosal epithelium. The CMC itself also swells, filling the voids in between.

[0030] Long-acting Gantrez salts also exhibit molecular cross-linking, resulting in an increase in the cohesive effect. Ultimately, all polymers become completely soluble and can be washed away by saliva. This dissolution is accelerated in the presence of hot liquids.

[0031] Currently, the effect of available denture adhesives on retention occurs in two ways:

[0032] 1. To increase the viscosity and the adhesive and cohesive properties of the saliva between the denture base and the supporting tissues.

[0033] 2. To eliminate the voids between the denture base and the area on which it rests.

[0034] Therefore, it is observed that these products, referred to as adhesives, enhance retention by affecting various properties of saliva, despite not having a significant adhesive property of their own. Consequently, these types of products cannot function optimally in many pathological conditions, especially those where salivary flow is reduced.

[0035] US2020397948A1 discloses dental adhesive hydrogels and their uses.

[0036] CN115998962A discloses a synthesis method for a tissue adhesive composite hydrogel and the application of the 'green series' of the tissue adhesive composite hydrogel in the treatment of peri-implantitis.

[0037] Upon reviewing the studies in the prior art, a need has been identified to develop a removable prosthesis adhesive that allows for the enhancement of retention in dental removable prostheses.

[0038] Objectives of the Invention

[0039] The object of the present invention is to develop a removable prosthesis adhesive that provides for the enhancement of retention in dental removable prostheses.

[0040] Another object of the present invention is to develop a removable prosthesis adhesive that provides excellent adhesion even in a completely moist environment such as the mouth. Another object of the present invention is to develop a removable prosthesis adhesive that exhibits its own adhesive properties, without altering the adhesive properties of saliva.

[0041] Detailed Description of the Invention

[0042] The invention relates to a removable prosthesis adhesive for enhancing the retention of dental removable prostheses, it comprises;

[0043] - Polydopamine.

[0044] Successful attempts have been made to produce mussel-inspired synthetic polymers, such as polydopamine (PDA), through a simple dip-coating method in an aqueous dopamine solution. The results of these studies allow for numerous potential biomedical applications, particularly in dentistry and tissue engineering, due to the challenging and moist environment of the oral cavity.

[0045] As bioadhesive technology has developed, its applications in the dental field have become a significant step in replacing the deteriorated fundamental anatomical structures of the periodontium. This includes regenerating periodontal tissues and the surrounding bone loss near dental implants in cases of periodontitis and peri- implantitis. Current research has primarily focused on functionalized PDA applications related to Guided Bone Regeneration (GBR), which are paired with biocompatible and biodegradable 3D polymer scaffolds made from materials approved by the Food and Drug Administration (FDA), such as polylactic acid (PLA).

[0046] Based on the foregoing, the denture adhesive to be produced contains polydopamine as the main structural material and is composed of various collagen materials (trade secret) which form a scaffold for this substance.

[0047] Due to its hydrophilic and biocompatible nature, its possession of multiple functional groups (amine and catechol), and its facilitation of the preparation of hybrid materials and sensors, PDA can be used as a protein recognition material. In recent years, biosensors prepared with PDA-coated electrodes and multifunctional PDA-coated carbon nanotubes both prepared by the spontaneous oxidative polymerization of dopamine have been the subject of many studies. The adhesive proteins of mussels possess the ability to bind strongly to most organic and inorganic surfaces, thanks to the extraordinary adhesive properties of the catechol and amine functional groups they contain. Dopamine, a small molecule generally known as a neurotransmitter, is a mimic of these adhesive proteins. Therefore, the polydopamine that serves as the main structural unit in the denture adhesive of the invention will not alter the adhesive properties of saliva, but will instead exhibit its own inherent adhesive properties. Its hydrophilic nature will ensure excellent adhesion in a moist environment such as the mouth.

[0048] References:

[0049] 1. The neutral zone in complete dentures Victor E. Beresin, DDS,a and Frank J. Schiesser, DDSb Temple University School of Dentistry, Philadelphia, Pa. THE JOURNAL OF PROSTHETIC DENTISTRY 95; 93-100 FEBRUARY 2006.

Claims

CLAIMS1. A removable prosthesis adhesive for enhancing the retention of dental removable prostheses, characterized in that it comprises Polydopamine.