Multi-zone microlens for corneal implantation and application thereof

Abstract

The present application belongs to the technical field of regenerative medicine. Provided is a multi-zone microlens for corneal implantation. The microlens has a circular curved surface and comprises two zones, namely, a first correction zone and a plano zone. The microlens preferably comprises three zones, namely, two vision correction zones and one plano zone, wherein the two vision correction zones each have the function of correcting vision, the diopter of the plano zone is 0D, and a through hole is provided in the center of the microlens. The applicant has discovered through extensive experimentation that providing the through hole in the center of the multi-zone microlens for corneal implantation can reduce the occurrence of post-operative corneal clouding and opacity. After the multi-zone microlens for corneal implantation provided in the present application is implanted, the patient will have clear vision for both near and distant objects, achieving full-range vision clarity. Further provided in the present application is an application of the multi-zone microlens for corneal implantation in vision correction.

Description

Partitioned corneal implantation microlenses and their applications

[0001] This application is based on and claims priority to Chinese Patent Application No. 202411628041.5, filed on November 14, 2024, the entire contents of which are incorporated herein by reference. Technical Field

[0002] This application belongs to the field of regenerative medicine technology. Specifically, the first aspect of this application relates to a microlens for partitioned corneal implantation, and the second aspect of this application relates to the application of the microlens product in products for correcting vision loss. Background Technology

[0003] As we age, or due to poor eye habits, vision declines. Presbyopia is a common vision problem. After age 40, the elasticity of the lens in the eye gradually weakens, and the eye's accommodative ability also gradually diminishes. This is the main cause of presbyopia, resulting in blurred vision when looking at close objects. Symptoms of presbyopia include: 1. Difficulty seeing very small print in low light; 2. Maintaining a greater reading distance when reading books or newspapers makes the eyes feel more comfortable; 3. Inability to sustain prolonged writing, reading, or fine motor work; 4. Greater comfort when reading newspapers without glasses; 5. Easily misreading prices when shopping; 6. Greater requirement for brighter light when reading books or newspapers compared to when younger.

[0004] Besides an unhealthy lens causing vision loss, refractive errors can also lead to decreased vision. For example, when the eye is in a relaxed state, parallel light rays entering the eye focus in front of the retina, resulting in a lack of a clear image on the retina, a condition known as myopia (nearsightedness). An eye exam in this case will indicate the degree of myopia. When the eye is relaxed, parallel light rays entering the eye focus precisely on the retina, forming a clear image; this is called emmetropia (normal vision). If the focus does not fall on the retina, it is called ametropia (non-emmetropia), or refractive error. Therefore, myopia is a symptom of refractive error.

[0005] Intraocular lenses are typically used to correct vision loss caused by unhealthy lens conditions. These lenses are usually inserted into the eye chamber, the eye capsule, or between the iris and the lens. US Patent document US2004 / 0085511A1 discloses an intraocular lens for insertion into the posterior chamber of the eye.

[0006] Intracorneal lenses are typically used to correct vision loss caused by refractive errors. These lenses are inserted into the cornea, not the eye chamber, and are therefore usually smaller than intraocular lenses. Because intracorneal and intraocular lenses are positioned differently relative to the lens, they must have different optical structures to correct vision loss. Chinese patent document CN101896853A discloses an intracorneal lens with a central aperture.

[0007] In the existing technology, no technology has been found that embeds a lens into the cornea to simultaneously correct vision loss caused by unhealthy lens conditions and vision loss caused by refractive errors. Summary of the Invention

[0008] To provide a basic understanding of some aspects of the disclosed embodiments, a brief summary is given below. This summary is not intended as a general commentary, nor is it intended to identify key / important components or describe the scope of protection of these embodiments, but rather as a prelude to the detailed description that follows.

[0009] The first aspect of this application provides a partitioned corneal implantation microlens, the microlens being a circular curved surface, the microlens comprising two regions, namely a first correction region and a plano region, the plano region being surrounded by the first correction region, the first correction region and the plano region being concentric, the first correction region having the function of correcting visual acuity, and the plano region having a refractive power of 0D.

[0010] The partitioned corneal implantable microlens provided in this application includes two regions: a first correction region that corrects visual acuity, and a plano region with a refractive power of 0D that does not correct visual acuity. The first correction region can be used to correct visual acuity loss caused by an unhealthy refractive mediator or by refractive errors. While the plano region does not correct visual acuity, it allows light to enter the eye parallel to the retina for clear imaging when viewing distant objects. Specifically, regardless of whether the first correction region is used to correct visual acuity loss due to an unhealthy refractive mediator or refractive errors, the plano region allows light to enter the eye parallel to the retina for clear imaging. This ensures that while the first correction region corrects visual acuity, the light entering the eye through the plano region maintains the patient's original accommodative ability, thus preventing distance vision loss or compensating for near vision loss. The zonal corneal implantation microlens provided in this application can, when used, change the specific shape of the first corrective zone and the area ratio between the two according to the patient's visual symptoms, thereby maximizing the correction of the patient's vision loss symptoms.

[0011] In a preferred embodiment of this application, the plano zone has a through-hole, which serves two purposes. First, it facilitates surgical marking. Specifically, since the microlens for partitioned corneal implantation provided in this application typically requires the center of the microlens to be on the visual axis during clinical application, otherwise it will affect the clinical effectiveness of visual correction. The through-hole can provide the surgeon with an accurate reference position, making it easier to find the center of the microlens and accurately position it on the visual axis. Second, after extensive experimentation, the applicant has found that setting a through-hole at the center of the microlens for partitioned corneal implantation can reduce postoperative corneal opacity and cloudiness.

[0012] In a preferred embodiment of this application, the plano region of the partitioned corneal implantation microlens provided in this application includes a second correction region. The plano region includes the second correction region, which is circular. The cross-section of the second correction region along the center of the circular curvature is a concave lens cross-section. The second correction region is surrounded by the remaining plano region of the plano region. In this preferred embodiment, the partitioned corneal implantation microlens has three regions: two vision correction regions and one plano region. The two vision correction regions each have the function of correcting vision, and can be used to correct vision loss caused by an unhealthy state of the refractive media, or to correct vision loss caused by refractive errors. The two vision correction regions can also respectively correct vision loss caused by the above two reasons. Although the plano region does not have the function of correcting vision, it allows light to enter the eye parallel to the retina, thereby alleviating the vision correction function of the first and second correction regions, and also compensating for unclear imaging caused by the self-accommodation function of the lens or refractive system. It should be noted that the second correction zone within the plano zone has a through-hole. The through-hole serves two purposes. First, it facilitates surgical marking. Specifically, since the microlens for partitioned corneal implantation provided in this application typically requires the center of the microlens to be on the visual axis during clinical application, otherwise it will affect the clinical effectiveness of visual correction. The through-hole can provide the surgeon with an accurate reference position, making it easier to find the center of the microlens and accurately position it on the visual axis. Second, after extensive experimentation, the applicant has found that setting a through-hole at the center of the microlens for partitioned corneal implantation can reduce postoperative corneal clouding and opacity.

[0013] In a preferred embodiment of this application, the first correction zone of the partitioned corneal implantation microlens provided in this application has the function of correcting vision loss caused by an unhealthy state of the refractive media, and the second correction zone has the function of correcting vision loss caused by refractive errors. Through extensive experimentation, the applicant has learned that although both the first and second correction zones can simultaneously correct vision loss caused by an unhealthy state of the refractive media, and simultaneously correct vision loss caused by refractive errors, when both the first and second correction zones have the function of correcting vision loss caused by an unhealthy state of the refractive media, the partitioned corneal implantation microlens provided in this application can simultaneously correct vision loss caused by an unhealthy state of the refractive media and vision loss caused by refractive errors, enabling patients to achieve full visual clarity post-surgery. Specifically, vision loss due to an unhealthy state of the refractive media causes patients to see distant objects clearly but near objects blurry. Vision loss due to refractive errors causes images to focus in front of or behind the retina, resulting in blurred vision. Therefore, after surgical implantation of the partitioned corneal implantation microlens provided in this application, when viewing near objects, due to iris constriction and pupil shrinkage, the cornea surrounding the first correction zone is appropriately blocked. At this time, all light passing through the first correction zone is corrected, thus compensating for the blurred vision in the plano and second correction zones caused by an unhealthy state of the refractive media and refractive errors, thereby improving postoperative vision. The patient's near vision becomes clearer; when viewing distant objects, the pupil dilates due to iris expansion, and the second corrective zone and plano zone work simultaneously, making the patient's distant vision even clearer. Furthermore, due to the stretching of the ciliary muscle when viewing distant objects, some light can enter the eye through the corneal area outside the edge of the first corrective zone of the lenticule implanted in the partitioned corneal implant, thus increasing the amount of light entering the eye. At the same time, due to the presence of the plano zone, intermediate vision is preserved when viewing distant objects. Through these two aspects, the patient's distant vision becomes clearer after surgery. In this way, the patient has clear vision for both near and distant objects after surgery, ultimately achieving full visual clarity.

[0014] In a preferred embodiment of this application, the microlens for zonal corneal implantation provided in this application has one through-hole, which is circular and concentric with the second correction zone, and the second correction zone is concentric with the plano zone. Through extensive experimentation, the applicant has concluded that, for the number of through-holes located in the second correction zone, multiple through-holes and one through-hole do not significantly differ in reducing postoperative corneal opacity and cloudiness. Furthermore, when the three regions of the microlens for zonal corneal implantation are arranged in the order of "from the center of the microlens outward: second correction zone, plano zone, first correction zone" (i.e., the second correction zone is surrounded by the plano zone, and the plano zone is surrounded by the first correction zone), the microlens for zonal corneal implantation can simultaneously correct visual impairment caused by unhealthy refractive media and visual impairment caused by refractive errors, enabling patients to achieve full visual clarity postoperatively. Specifically, vision loss due to an unhealthy state of the refractive media causes patients to see distant objects clearly but near objects blurry. Vision loss due to refractive errors can cause images to focus in front of or behind the retina, resulting in blurred vision. Therefore, after surgical implantation of the partitioned corneal implantation microlens provided in this application, when viewing near objects, the iris constricts and the pupil narrows, thus appropriately blocking light outside the first correction zone. At this time, light passing through both the first and second correction zones is corrected, compensating for the blurred vision in the plano area caused by the unhealthy state of the refractive media, thereby improving the postoperative vision of the patient. The vision becomes clearer when viewing near objects; when viewing distant objects, due to iris dilation and pupil expansion, the second correction zone and the plano zone work simultaneously, making the patient's vision clearer when viewing distant objects. Furthermore, due to ciliary muscle stretching when viewing distant objects, some light can pass through the area outside the edge of the first correction zone of the segmented corneal implant microlens and enter the eye, increasing the amount of light entering the eye. Simultaneously, the presence of the plano zone preserves intermediate-distance vision when viewing distant objects. Through these two aspects, the patient's vision becomes clearer when viewing distant objects post-surgery. Thus, the patient has clear vision for both near and distant objects post-surgery, ultimately achieving full visual clarity. Therefore, after extensive testing, the applicant concluded that this preferred embodiment is particularly effective in correcting vision loss in patients with both presbyopia and myopia.

[0015] In a non-limiting embodiment of this application, the vision loss caused by the unhealthy state of the refractive medium refers to vision loss caused by the lens due to lack of accommodation, incomplete opacity, or weakened elasticity, such as presbyopia; the vision loss caused by refractive error refers to the inability of parallel light rays to form a clear image on the retina after passing through the eye's refractive system, but instead forming an image in front of or behind the retina, such as hyperopia, myopia, and astigmatism. Thus, the first and second correction zones of the partitioned corneal implantation microlens provided in this application respectively have the function of correcting the above two types of vision loss, thereby enabling patients to achieve full vision after surgery.

[0016] After extensive testing, the applicant concluded that when the cross-section of the first correction zone along the direction of the annular curvature center is a convex lens cross-section, it can effectively correct vision loss caused by the unhealthy state of the refractive media. This is because after the patient undergoes surgery to implant the partitioned corneal implantation microlens provided in this application, especially when the patient is viewing near objects post-surgery, the pupil constricts due to iris contraction, causing the area outside the first correction zone to be appropriately blocked. At this time, the light passing through the first and second correction zones will be corrected. The convex lens function of the first correction zone will compensate for the blurred vision in the plano and second correction zones caused by the unhealthy state of the refractive media, thereby making the patient's near vision clearer post-surgery.

[0017] In a further preferred embodiment of this application, the cross-section of the first correction zone along the center of the annular curvature is a convex lens cross-section, and the cross-section of the second correction zone along the center of the circular curvature is a concave lens cross-section. In this embodiment, the partitioned corneal implantation microlens provided by this application can effectively correct myopia caused by refractive errors, resulting in clear near vision but blurred distance vision. This is because, after the patient undergoes surgery to implant the partitioned corneal implantation microlens provided by this application, especially when the patient is viewing distant objects post-surgery, firstly, due to iris dilation and pupil expansion, the second correction zone, the plano zone, and the first correction zone will all function simultaneously. Furthermore, due to ciliary muscle stretching when viewing distant objects, some light can pass through the partitioned corneal implantation microlens. First, the corneal region outside the edge of the first correction zone of the lens enters the eye, thus increasing the amount of light entering the eye. Second, due to the presence of the plano zone, the original visual accommodation ability caused by the unhealthy state of the refractive media is preserved, thereby compensating for intermediate-distance vision and the total amount of light entering the eye. Third, since the cross-section of the second correction zone along the center of the circular curvature is a concave lens cross-section, it plays the role of a concave lens in correcting myopia, and the aperture is concentric with the second correction zone, which means that the optical center of the second correction zone (i.e., the concave lens) is the aperture. This avoids light reflection caused by the thickness of the cross-section, thereby avoiding glare. Due to these three factors, the patient's vision of distant objects becomes clearer after surgery.

[0018] After extensive experimentation, the applicant concluded that when the cross-section of the first correction zone along the center of the annular curvature is a convex lens cross-section, the cross-section of the second correction zone along the center of the circular curvature is a concave lens cross-section, and the through-hole is circular and concentric with the second correction zone, it is particularly suitable for patients with presbyopia caused by an unhealthy refractive medium and myopia caused by refractive errors. This is because presbyopia causes patients to see distant objects clearly but near objects are blurry, while myopia causes patients to see near objects clearly but distant objects are blurry. Therefore, after the patient undergoes surgery to implant the partitioned corneal implantation microlens provided in this application, when viewing near objects, due to iris contraction and pupil constriction, the area outside the first correction zone is appropriately blocked. At this time, the convex lens function of the first correction zone will compensate for the plano area and the second correction zone. Because presbyopia causes blurred vision, this procedure improves near vision for postoperative patients. When viewing distant objects, the iris dilates and the pupil expands, allowing the concave lens in the second correction zone, the plano lens in the first correction zone, and the convex lens in the first correction zone to work simultaneously, further enhancing distance vision. Furthermore, due to ciliary muscle stretching during distance vision, some light can enter the eye through the area outside the edge of the first correction zone of the segmented corneal implantation microlens, increasing the amount of light entering the eye. Simultaneously, the plano zone preserves the relatively clear intermediate-distance vision that presbyopic patients originally possessed. Through these two aspects, the segmented corneal implantation microlens provided in this application can improve distance vision for postoperative patients. Thus, postoperative patients achieve clear near and distance vision, ultimately realizing full-clear vision after surgery.

[0019] In a preferred embodiment of this application, the number of through holes is one, and the through hole is located at the optical center of the concave lens, i.e., the thinnest part of the concave lens in the second correction zone is 0 mm. Through extensive experimentation, the applicant has found that the diameter of the through hole is related to the occurrence of corneal opacity and cloudiness after surgery. When the surgeon positions the center of the partitioned corneal implantation microlens (i.e., the center of the second correction zone) on the visual axis, and the through hole diameter is 0.01–0.6 mm, it facilitates the positioning of the partitioned corneal implantation microlens on the visual axis during clinical transplantation, while also reducing the occurrence of corneal opacity and cloudiness after surgery.

[0020] In a preferred embodiment of this application, the diameter of the microlens for partitioned corneal implantation is 2.5–5.5 mm, which is related to the individual corneal size of the patient. The applicant has concluded through extensive experiments that the appropriate size of the inlay to be embedded in the human cornea is 2.5–5.5 mm in diameter and 25–63 μm in thickness. According to the correction principle of the microlens for partitioned corneal implantation provided in this application, when the diameter is 3.0–4.0 mm and the thickness is 25–55 μm, it is easier to achieve full-clear vision.

[0021] In a non-limiting preferred embodiment of this application, to prolong the lifespan of the microlens for partitioned corneal implantation and reduce ultraviolet damage to other intraocular tissues, the applicant added azophenyl methacrylate to the microlens. In a non-limiting preferred embodiment of this application, 4-propenoxy-2-hydroxybenzophenone was added to the material used to prepare the microlens for partitioned corneal implantation. In a non-limiting preferred embodiment of this application, both azophenyl methacrylate and 4-propenoxy-2-hydroxybenzophenone were added to the material used to prepare the microlens for partitioned corneal implantation. Through extensive testing, the applicant found that when the material used to prepare the microlens for partitioned corneal implantation is hydroxyethyl methacrylate or methyl methacrylate, and the ultraviolet blocking agent is 4-propenoxy-2-hydroxybenzophenone, the transparency, biocompatibility, sustained antibiotic release effect, and lifespan of the transplanted microlens are all better.

[0022] The second aspect of this application provides the application of a partitioned corneal implantation microlens in a product for correcting vision loss caused by an unhealthy state of the refractive media. The second aspect of this application also provides the application of a partitioned corneal implantation microlens in a product for correcting vision loss caused by refractive errors.

[0023] The partitioned corneal implantation microlens provided in this application includes two regions and a through-hole. Since the first correction region corrects vision loss caused by an unhealthy refractive media or by refractive errors, and the plano region has a refractive power of 0D, after implantation of this partitioned corneal implantation microlens, regardless of whether the first correction region is used to correct vision loss caused by an unhealthy refractive media or by refractive errors, the plano region allows light to enter the eye parallel to the retina, achieving clear imaging. This ensures that while the first correction region corrects vision, light entering the eye through the plano region can maintain the patient's original visual accommodation. The applicant, after extensive experimentation, found that placing a through-hole at the center of the partitioned corneal implantation microlens not only facilitates surgical marking but also reduces postoperative corneal clouding and opacity.

[0024] In a preferred embodiment of this application, the plano zone of the partitioned corneal implantation microlens further includes a second correction zone. In this case, the partitioned corneal implantation microlens has three regions: two vision correction zones and one plano zone. From the center of the partitioned corneal implantation microlens outward, the regions are: the second correction zone, the plano zone, and the first correction zone. That is, the second correction zone is surrounded by the plano zone, and the plano zone is surrounded by the first correction zone. Although the plano zone, which is located between the two correction zones, does not have the function of correcting vision, it can allow light to enter the eye parallel to the retina. Thus, while alleviating the vision correction function of the first correction zone, it can also compensate for the unclear imaging caused by the self-accommodation function of the lens or refractive system. In particular, after implantation in the patient's non-dominant eye, when viewing near objects, due to iris contraction and pupil constriction, the area outside the first correction zone is appropriately blocked. At this time, all light passing through the first correction zone is corrected, thus compensating for the blurred vision in the plano and second correction zones caused by unhealthy refractive media and refractive errors, resulting in clearer near vision post-surgery. When viewing distant objects, due to iris extension and pupil dilation, both the second correction zone and the plano zone function simultaneously. Due to ciliary muscle stretching, some light can pass through the area outside the edge of the first correction zone of the segmented corneal implantation microlens. The increased light entering the eye, combined with the preservation of intermediate-distance vision due to the presence of the plano-optic zone, results in clearer vision for distant objects after surgery, especially for the non-dominant eye. Furthermore, when the eyes perceive objects differently (the clearer image is the dominant eye, and the less clear image is the non-dominant eye), the body actively selects the clearer image as the primary image, appropriately ignoring the less clear image. Therefore, postoperatively, patients experience clear vision for both near and distant objects, ultimately achieving full visual clarity. See Appendix 5 for a visual effect simulation.

[0025] The above general description and the description below are exemplary and illustrative only and are not intended to limit this application. Attached Figure Description

[0026] One or more embodiments are illustrated by way of example with reference to the accompanying drawings. These illustrations and drawings do not constitute a limitation on the embodiments, and wherein:

[0027] Figure 1 is an enlarged schematic diagram of the partitioned corneal implantation microlens provided in this application.

[0028] Figure 2 shows a vertical cross-section through the optical center of the partitioned corneal implantation microlens (three example microlenses) provided in this application.

[0029] Figure 3 is a schematic diagram illustrating the working principle of the partitioned corneal implantation microlens provided in Embodiment 10 of this application when used for near vision after implantation into the patient's cornea.

[0030] Figure 4 is a schematic diagram illustrating the working principle of the partitioned corneal implantation microlens provided in Embodiment 10 of this application when viewing distant objects after implantation into the patient's cornea.

[0031] Figure 5 is a simulation diagram of the binocular vision effect after implantation of the partitioned corneal implantation microlens provided in Embodiment 11 of this application into the patient's cornea. Detailed Implementation

[0032] To provide a more detailed understanding of the features and technical content of the embodiments of this disclosure, the implementation of the embodiments of this disclosure will be described in detail below with reference to the accompanying drawings. The accompanying drawings are for illustrative purposes only and are not intended to limit the embodiments of this disclosure. In the following technical description, for ease of explanation, several details are used to provide a full understanding of the disclosed embodiments. However, one or more embodiments may still be implemented without these details.

[0033] Any reference to prior art in the specification is not and should not be construed as an admission or in any way an implication that such prior art constitutes part of common general knowledge in the application region or any other jurisdiction, or that such prior art could be reasonably understood and regarded as relevant by a person skilled in the art.

[0034] The term "microlens for zonal corneal implantation" in the specification, claims, and accompanying drawings of this disclosure refers to a membrane that can be embedded in the corneal stroma and can correct vision.

[0035] The "surface" mentioned in this disclosure refers to the surface generated by the trajectory of a straight line or curve under certain constraints. The surfaces mentioned in this disclosure include spherical surfaces, cylindrical surfaces, and conical surfaces.

[0036] In this embodiment of the disclosure, "concentric" refers to the situation where the centroids or centers of two or more regions (such as circles) coincide.

[0037] The "optical center" mentioned in the embodiments of this disclosure refers to the optical center in the physical sense. For example, the optical center of a concave lens is the point where the centers of the two refracting surfaces coincide. The characteristic of the optical center is that the direction of light propagation through this point remains unchanged.

[0038] The term "curvature" in this disclosure refers to the curvature of a curve in a mathematical sense, used to indicate the degree of bending of the curve at a certain point. The greater the curvature, the greater the degree of bending of the curve.

[0039] The "concave lens" described in this disclosure refers to a concave lens in the optical sense, meaning a lens that is thinner in the middle and thicker at the edges, forming a concave shape. The concave lens described in this disclosure includes lenses with one flat surface and one concave surface, and lenses with both concave surfaces.

[0040] The "convex lens" described in this disclosure refers to a convex lens in the optical sense, meaning a lens that is thicker in the middle and thinner at the edges, exhibiting a convex shape. The convex lens described in this disclosure includes lenses with one flat surface and another convex surface, as well as lenses with both surfaces being convex. The convex lens is a complete convex lens along the direction perpendicular to the principal optical axis, and also includes incomplete convex lenses along the same direction, including lenses that are half-convex lenses along the same direction, where the thickest part of the convex lens is the same as the thickness of the flat optical region.

[0041] The "refractive media" mentioned in the embodiments of this disclosure refers to medically significant refractive media such as the lens and vitreous body.

[0042] The "unhealthy state of the refractive media" mentioned in this disclosure refers to vision loss caused by a lack of accommodation, incomplete opacity, and reduced elasticity of the lens, such as presbyopia.

[0043] The "refractive error" described in this disclosure refers to the inability of parallel light rays to form a clear image on the retina after passing through the eye's refractive power, instead forming an image in front of or behind the retina.

[0044] The "decreased vision" described in this disclosure refers to the phenomenon where, compared to normal vision of 1.0, vision testing shows that the vision is less than 1.0, resulting in blurred vision and difficulty in distinguishing small or distant objects.

[0045] In this embodiment of the disclosure, "VB12" refers to vitamin B12.

[0046] The “bFGF” mentioned in this disclosure refers to basic fibroblast growth factor.

[0047] It should be noted that, unless otherwise specified, the embodiments and features described in the present disclosure can be combined with each other.

[0048] The following description, in conjunction with the accompanying drawings, further illustrates non-limiting embodiments of the present disclosure, using experimental rabbits instead of human patients to illustrate the specific steps of the parameters and preparation method of the corneal embedded microlens provided in the embodiments of the present disclosure. It should be noted that the following specific embodiments are merely illustrative and should not be construed as limiting the technical solutions of this application.

[0049] Example 1

[0050] This embodiment illustrates a partitioned corneal implantation microlens. The microlens has a circular curved surface and includes two regions: a first corrective region and a plano region. The plano region is surrounded by the first corrective region, and the two regions are concentric. The first corrective region corrects visual acuity, and the plano region has a refractive power of 0D. The first corrective region can be used to correct visual acuity loss caused by an unhealthy state of the refractive media or by refractive errors. The plano region does not correct visual acuity. In use, the partitioned corneal implantation microlens provided in this embodiment can adjust the specific shape and area ratio of the first corrective region and the plano region according to the patient's visual symptoms, thereby maximizing the correction of the patient's visual acuity loss.

[0051] Materials, conditions, and parameters not described in this embodiment can be selected by those skilled in the art through creative effort to implement the procedure by choosing reagents, materials, parameters, and specific settings, thereby obtaining a zonal corneal implantation microlens with vision-correcting effects.

[0052] Example 2

[0053] This embodiment illustrates a partitioned corneal implantation microlens. Based on Embodiment 1, the microlens includes two regions: a "first correction zone" and a "plano zone." The first correction zone corrects vision loss caused by an unhealthy state of the refractive media, while the plano zone does not correct vision. The plano zone is a circle with a diameter of 2 mm and a thickness of 25 μm. Outside the plano zone is a ring-shaped first correction zone. The inner circumference of the first correction zone has the same thickness as the plano zone, and the outer diameter of the first correction zone is 4 mm (i.e., the diameter of the partitioned corneal implantation microlens). The maximum thickness of this partitioned corneal implantation microlens is 54 μm.

[0054] Materials, conditions, and parameters not described in this embodiment can be selected by those skilled in the art through creative effort to implement the procedure by choosing reagents, materials, parameters, and specific settings, thereby obtaining a zonal corneal implantation microlens with vision-correcting effects.

[0055] Example 3

[0056] This embodiment illustrates a partitioned corneal implantation microlens. Based on Embodiment 1, the plano zone further includes a second correction zone. In this case, the partitioned corneal implantation microlens has three regions: two correction zones and one plano zone. The three regions are arranged in the following order from the center outwards: second correction zone, plano zone, and first correction zone. The first correction zone corrects vision loss caused by an unhealthy state of the refractive media, the plano zone does not correct vision, and the second correction zone corrects vision loss caused by refractive errors. The microlens for this partitioned corneal implantation is circular. The second correction zone is a circle with a diameter of 1.5 mm and a maximum thickness of 30 μm. Outside the second correction zone is a ring-shaped plano zone with an outer diameter of 2.5 mm. The thickness of the plano zone is the same as the thickness of the edge of the second correction zone. Outside the plano zone is a ring-shaped first correction zone with an outer diameter of 3.5 mm (i.e., the diameter of the microlens for this partitioned corneal implantation). The maximum thickness of the inner circumference of the first correction zone is the same as the thickness of the plano zone.

[0057] Materials, conditions, and parameters not described in this embodiment can be selected by those skilled in the art through creative effort to implement the procedure by choosing reagents, materials, parameters, and specific settings, thereby obtaining a zonal corneal implantation microlens with vision-correcting effects.

[0058] Example 4

[0059] This embodiment illustrates a partitioned corneal implantation microlens. Based on Embodiment 1, this partitioned corneal implantation microlens has three regions: two correction zones and one plano zone. The three regions are arranged in the following order from the center outwards: second correction zone, plano zone, and first correction zone. The first correction zone corrects vision loss caused by an unhealthy state of the refractive media. The plano zone does not correct vision. The second correction zone also corrects vision loss caused by an unhealthy state of the refractive media. The microlens for this partitioned corneal implantation is circular. The second correction zone is a circle with a diameter of 2 mm and a maximum thickness of 42 μm. Outside the second correction zone is a ring-shaped plano zone with an outer diameter of 2.5 mm. The thickness of the plano zone is the same as the thickness of the edge of the second correction zone. Outside the plano zone is a ring-shaped first correction zone with an outer diameter of 3.2 mm (i.e., the diameter of the microlens for this partitioned corneal implantation). The cross-sectional thickness of the inner circumference of the ring-shaped first correction zone is the same as the thickness of the plano zone.

[0060] Materials, conditions, and parameters not described in this embodiment can be selected by those skilled in the art through creative effort to implement the procedure by choosing reagents, materials, parameters, and specific settings, thereby obtaining a zonal corneal implantation microlens with vision-correcting effects.

[0061] Example 5

[0062] This embodiment illustrates a partitioned corneal implantation microlens. Based on Embodiment 1, this partitioned corneal implantation microlens has three regions: two correction zones and one plano zone. The three regions are arranged in the following order from the center outwards: second correction zone, plano zone, and first correction zone. The first correction zone corrects vision loss caused by an unhealthy state of the refractive media, the plano zone does not correct vision, and the second correction zone corrects vision loss caused by refractive errors. The microlens for this partitioned corneal implantation is circular. The second correction zone is a circle with a diameter of 1.5 mm and a maximum thickness of 54 μm. Outside the second correction zone is a ring-shaped plano zone with an outer diameter of 2 mm and a thickness equal to the edge thickness of the second correction zone. Outside the plano zone is a ring-shaped first correction zone with an outer diameter of 4.5 mm (i.e., the diameter of the microlens for this partitioned corneal implantation). The cross-sectional thickness of the inner circumference of the ring-shaped first correction zone is the same as the thickness of the plano zone.

[0063] Materials, conditions, and parameters not described in this embodiment can be selected by those skilled in the art through creative effort to implement the procedure by choosing reagents, materials, parameters, and specific settings, thereby obtaining a zonal corneal implantation microlens with vision-correcting effects.

[0064] Example 6

[0065] This embodiment illustrates a partitioned corneal implantation microlens. Based on Embodiment 1, and taking Figure 1 as an example, this partitioned corneal implantation microlens has three regions: two correction zones and one plano zone. The three regions are arranged in the following order from the center of the partitioned corneal implantation microlens outwards: second correction zone S3, plano zone S2, and first correction zone S1. The partitioned corneal implantation microlens is circular. The second correction zone S3 is a circle with a diameter of 1.5 mm and is a concave lens. The thickness of the concave lens edge is 45 μm, and the thickness at the optical center is 0 μm. Extending outwards from the optical center, it extends to a circular aperture with a diameter of 0.4 mm. The entire circular aperture is a through-hole SH, i.e., with a thickness of 0 μm. The thickness from the edge of the through-hole SH to the second correction zone gradually increases from 0 μm. Outside the second correction zone S3 is the annular plano zone S2, with an outer diameter of 2.5 mm. The thickness of S2 is the same as the thickness of the edge of the concave lens in the second correction zone S3; outside the plano zone S2 is the annular first correction zone S1, and the cross section of the first correction zone S1 along the direction of the center of the annular curvature is the cross section of a convex lens. The thickness of the convex lens in the first correction zone S1 at the junction with the plano zone S2 is the same as that of the plano zone S2. The outer diameter of the first correction zone S1 is 4.0 mm (i.e., the diameter of the microlens for this partitioned corneal implantation), and the optical center thickness of the convex lens in the first correction zone S1 is 54 μm (i.e., the thickness of the thickest part of the microlens for this partitioned corneal implantation).

[0066] It should be noted that in the three regions of the corneal embedded microlens in this embodiment, the concave and convex lenses respectively include the four cases shown in Figure 2, namely, one of the two surfaces of the concave lens (or convex lens) is a plane and the other is a concave (or convex) surface, and also includes the case where both surfaces are concave (or convex). The convex lens is a complete convex lens along the direction perpendicular to the principal optical axis, and also includes an incomplete convex lens along the direction perpendicular to the principal optical axis, including a convex lens that is half a convex lens along the direction perpendicular to the principal optical axis, in which case the thickest part of the convex lens is the same as the thickness of the plano region.

[0067] Materials, conditions, and parameters not described in this embodiment can be selected by those skilled in the art through creative effort to implement the procedure by choosing reagents, materials, parameters, and specific settings, thereby obtaining a zonal corneal implantation microlens with vision-correcting effects.

[0068] Example 7

[0069] This embodiment illustrates a partitioned corneal implantation microlens. Based on Embodiment 1, this partitioned corneal implantation microlens has three regions: two correction zones and one plano zone. The three regions are arranged in the following order from the center outwards: second correction zone, plano zone, and first correction zone. The partitioned corneal implantation microlens is circular. The second correction zone is a circle with a diameter of 1.5 mm and is a concave lens with an edge thickness of 47 μm and a thickness of 0 μm at the optical center. It then extends outwards from the optical center to a circular aperture with a diameter of 0.35 mm. This entire aperture is a through-hole, meaning its thickness is 0 μm. The thickness gradually increases from the edge of the through-hole to the second correction zone. Outside the second correction zone is a ring-shaped plano zone with an outer diameter of 2.0 mm. The thickness of the plano zone is the same as the thickness of the edge of the concave lens in the second correction zone. Outside the plano zone is a ring-shaped first correction zone. The cross-section of the first correction zone along the center of the ring's curvature is a convex lens cross-section. The thickness of the convex lens in the first correction zone at its junction with the plano zone is the same as that of the plano zone. The outer diameter of the first correction zone is 3.3 mm (i.e., the diameter of this partitioned corneal implantation microlens), and the optical center thickness of the convex lens in the first correction zone is 63 μm (i.e., the thickness at the thickest point of this partitioned corneal implantation microlens). The material used to prepare this partitioned corneal implantation microlens is one or more of the following: hydroxyethyl methacrylate, 2-phenoxyethyl acrylate, ethylene glycol dimethacrylate, methyl methacrylate, polymethyl methacrylate, and styrene acrylate.

[0070] It should be noted that in the three regions of the corneal embedded microlens in this embodiment, the concave and convex lenses respectively include the four cases shown in Figure 2, namely, one of the two surfaces of the concave lens (or convex lens) is a plane and the other is a concave (or convex) surface, and also includes the case where both surfaces are concave (or convex). The convex lens is a complete convex lens along the direction perpendicular to the principal optical axis, and also includes an incomplete convex lens along the direction perpendicular to the principal optical axis, including a convex lens that is half a convex lens along the direction perpendicular to the principal optical axis, in which case the thickest part of the convex lens is the same as the thickness of the plano region.

[0071] Materials, conditions, and parameters not described in this embodiment can be selected by those skilled in the art through creative effort to implement the procedure by choosing reagents, materials, parameters, and specific settings, thereby obtaining a zonal corneal implantation microlens with vision-correcting effects.

[0072] Example 8

[0073] This embodiment illustrates a partitioned corneal implantation microlens. Based on Embodiment 1, the partitioned corneal implantation microlens has three regions: two correction zones and one plano zone. The three regions are arranged in the following order from the center of the partitioned corneal implantation microlens outward: second correction zone, plano zone, and first correction zone. The microlens for this partitioned corneal implantation is circular. The second correction zone is a 2mm diameter circle and is a concave lens with an edge thickness of 48μm and a zero thickness at the optical center. It extends outward from the optical center to a 0.6mm diameter circular aperture, which is a through-hole with a thickness of zero. The thickness of the second correction zone gradually increases from zero at the edge of the aperture. Outside the second correction zone is a ring-shaped plano zone with an outer diameter of 2.5mm and a thickness equal to that of the concave lens edge. Outside the plano zone is a ring-shaped first correction zone. The cross-section of the first correction zone along the direction of the ring's curvature is a convex lens cross-section. The junction of the convex lens and the plano zone in the first correction zone has the same thickness as the plano zone. The outer diameter of the first correction zone is 4mm (the diameter of the microlens for this partitioned corneal implantation), and the optical center thickness of the convex lens in the first correction zone is 62μm (the thickness at the thickest point of the microlens for this partitioned corneal implantation). The material used to prepare the partitioned corneal implant microlens is one or more of the following: hydroxyethyl methacrylate, 2-phenoxyethyl acrylate, ethylene glycol dimethacrylate, methyl methacrylate, polymethyl methacrylate, and styrene acrylate. The ultraviolet blocking agent for the partitioned corneal implant microlens is azophenyl methacrylate and / or 4-propenoxy-2-hydroxybenzophenone.

[0074] It should be noted that in the three regions of the corneal embedded microlens exemplified in this embodiment, the concave lens in the second correction region and the convex lens in the first correction region respectively include the four cases shown in Figure 2, namely, one of the two surfaces of the concave lens (or convex lens) is a plane and the other is a concave (or convex) surface, and also includes the case where both surfaces are concave (or convex). The convex lens is a complete convex lens along the direction perpendicular to the principal optical axis, and also includes an incomplete convex lens along the direction perpendicular to the principal optical axis, including a convex lens that is half a convex lens along the direction perpendicular to the principal optical axis, in which case the thickest part of the convex lens is the same as the thickness of the plano region. Materials, conditions, and parameters not described in this embodiment can be implemented by those skilled in the art with creative effort by selecting reagents, materials, parameters, and specific settings to obtain a partitioned corneal implantation microlens with vision-correcting effects.

[0075] Example 9

[0076] This embodiment illustrates a partitioned corneal implantation microlens. Based on Embodiment 1, this partitioned corneal implantation microlens has three regions: two correction zones and one plano zone. The three regions are arranged in the following order from the center of the partitioned corneal implantation microlens outwards: second correction zone, plano zone, and first correction zone. The partitioned corneal implantation microlens is circular. The second correction zone is a circle with a diameter of 1.5 mm and is a concave lens with an edge thickness of 34 μm and a thickness of 0 μm at the optical center. It then extends outwards from the optical center to a circular aperture with a diameter of 0.3 mm. This entire aperture is a through-hole, meaning its thickness is 0 μm. The thickness gradually increases from the edge of the through-hole to the second correction zone. Outside the second correction zone is a ring-shaped plano zone with an outer diameter of 2.3 mm. The thickness of the plano zone is the same as the thickness of the edge of the concave lens in the second correction zone. Outside the plano zone is the annular first correction zone. The cross-section of the first correction zone along the center of the annular curvature is the cross-section of a convex lens. The thickness of the convex lens in the first correction zone at its junction with the plano zone is the same as that of the plano zone. The outer diameter of the first correction zone is 3.5 mm (i.e., the diameter of this partitioned corneal implantation microlens), and the optical center thickness of the convex lens in the first correction zone is 52 μm (i.e., the thickness at the thickest point of this partitioned corneal implantation microlens). The material used to prepare this partitioned corneal implantation microlens is a combination of hydroxyethyl methacrylate and methyl methacrylate. The ultraviolet blocking agent for this partitioned corneal implantation microlens is 4-propenoxy-2-hydroxybenzophenone.

[0077] Materials, conditions, and parameters not described in this embodiment can be selected by those skilled in the art through creative effort to implement the procedure by choosing reagents, materials, parameters, and specific settings, thereby obtaining a zonal corneal implantation microlens with vision-correcting effects.

[0078] Example 10

[0079] This embodiment illustrates a partitioned corneal implantation microlens. Based on Embodiment 1, this partitioned corneal implantation microlens has three regions: two correction zones and one plano zone. The three regions are arranged in the following order from the center outwards: second correction zone, plano zone, and first correction zone. The partitioned corneal implantation microlens is circular. The second correction zone is a circle with a diameter of 1.6 mm and is a concave lens with an edge thickness of 48 μm. The thickness at the optical center of the concave lens is 0 μm. Extending outwards from the optical center, a circular aperture with a diameter of 0.2 mm is formed. This aperture is entirely through-hole, meaning its thickness is 0 μm. The thickness gradually increases from the edge of the through-hole to the second correction zone. Outside the second correction zone is a ring-shaped plano zone with an outer diameter of 2.2 mm. The thickness of the plano zone is the same as the thickness of the edge of the concave lens in the second correction zone. Outside the plano zone is the annular first correction zone. The cross-section of the first correction zone along the center of the annular curvature is the cross-section of a convex lens. The thickness of the convex lens in the first correction zone at its junction with the plano zone is the same as that of the plano zone. The outer diameter of the first correction zone is 3.4 mm (i.e., the diameter of this partitioned corneal implantation microlens), and the optical center thickness of the convex lens in the first correction zone is 67 μm (i.e., the thickness at the thickest point of this partitioned corneal implantation microlens). The material used to prepare this partitioned corneal implantation microlens is a combination of hydroxyethyl methacrylate and methyl methacrylate, and the ultraviolet blocking agent is azophenyl methacrylate.

[0080] It should be noted that in the three regions of the corneal embedded microlens in this embodiment, the concave lens in the second correction region and the convex lens in the first correction region respectively include the four cases shown in Figure 2, namely, one of the two surfaces of the concave lens (or convex lens) is a plane and the other is a concave (or convex) surface, and also includes the case where both surfaces are concave (or convex). The convex lens is a complete convex lens along the direction perpendicular to the principal optical axis, and also includes an incomplete convex lens along the direction perpendicular to the principal optical axis, including a convex lens that is half a convex lens along the direction perpendicular to the principal optical axis, in which case the thickest part of the convex lens is the same as the thickness of the plano region.

[0081] Example 11

[0082] This embodiment illustrates a partitioned corneal implantation microlens. Based on Embodiment 1, this partitioned corneal implantation microlens has three regions: two correction zones and one plano zone. The three regions are arranged in the following order from the center of the partitioned corneal implantation microlens outwards: second correction zone, plano zone, and first correction zone. This partitioned corneal implantation microlens is circular. The second correction zone is a circle with a diameter of 1.4 mm and is a concave lens with an edge thickness of 37 μm and a thickness of 0 μm at the optical center. It then extends outwards from the optical center to a circular aperture with a diameter of 0.3 mm. This entire aperture is a through-hole, meaning its thickness is 0 μm. The thickness gradually increases from the edge of the through-hole to the second correction zone. Outside the second correction zone is a ring-shaped plano zone with an outer diameter of 2.0 mm. The thickness of the plano zone is the same as the thickness of the edge of the concave lens in the second correction zone. Outside the plano zone is the annular first correction zone. The cross-section of the first correction zone along the center of the annular curvature is the cross-section of a convex lens. The thickness of the convex lens in the first correction zone at the junction with the plano zone is the same as that of the plano zone. The outer diameter of the first correction zone is 3.6 mm (i.e., the diameter of this partitioned corneal implantation microlens), and the optical center thickness of the convex lens in the first correction zone is 55 μm (i.e., the thickness at the thickest point of this partitioned corneal implantation microlens). The material used to prepare this partitioned corneal implantation microlens is a combination of hydroxyethyl methacrylate and methyl methacrylate, and the ultraviolet blocking agent is 4-propenoxy-2-hydroxybenzophenone. The corneal embedded microlens prepared in this embodiment is shown in Figure 2-B of Figure 2. A simulation illustration of its full-clear visual imaging effect is shown in Figure 5.

[0083] Example 12

[0084] This embodiment illustrates the incidence of corneal opacity or cloudiness after the partitioned corneal implantation microlens provided in Embodiment 11 was implanted into the cornea of ​​an animal. Details are as follows:

[0085] I. Experimental Materials and Equipment:

[0086] 1. Twelve rabbits were used in the experiment;

[0087] 2. Experimental materials: 6 microlenses for partitioned corneal implantation provided in Example 11;

[0088] 3. Comparative materials: Six microlenses for partitioned corneal implantation that are exactly the same size as those provided in Example 11, but do not have a central hole;

[0089] 4. Physiological saline, lidocaine hydrochloride, etc.

[0090] 5. Main equipment: surgical microscope, facial incision device, ophthalmic separator, implanter, sling, surgical instruments, slit lamp, ophthalmic B-ultrasound, etc.

[0091] II. Experimental Procedure

[0092] 1. Experimental grouping: 6 rabbits in the control group were numbered and implanted with the control material (a microlens for partitioned corneal implantation without a central hole); 6 rabbits in the experimental group were numbered and implanted with the experimental material (a microlens for partitioned corneal implantation with a central hole provided in Example 11).

[0093] 2. Experimental Procedure: The operated eyes of the rabbits were cleaned before surgery. A corneal stromal capsule was then prepared using a scalpel. After separating the capsule with a separator, a microlens was inserted into the capsule using a surgical implanter. Postoperatively, tobramycin-dexamethasone eye drops were administered according to the instructions. The rabbits were observed for 12 months postoperatively.

[0094] III. Scoring Criteria

[0095] IV. Test Results

[0096] The scores were recorded at 3 months, 6 months, and 12 months post-surgery, as follows:

[0097] V. Experimental Conclusions

[0098] The experimental results showed that the rabbits implanted with the partitioned corneal implantation microlens with a central hole remained completely transparent for 12 consecutive months, without any corneal opacity or clouding. In the control group, three cases of corneal opacity and clouding occurred at 6 months, and these symptoms tended to worsen at 12 months. In conclusion, the partitioned corneal implantation microlens with a central hole provided in Example 11 did not cause corneal opacity or clouding for 12 consecutive months.

[0099] Example 13

[0100] This embodiment illustrates a partitioned corneal implantation microlens with ultraviolet blocking function, and evaluates the application effects of the partitioned corneal implantation microlenses provided in Examples 10 and 11 through aging, transparency, biocompatibility, and sustained antibiotic release tests. Details are as follows:

[0101] Experimental group 1: The partitioned corneal implantation microlens provided in Example 10;

[0102] Experimental group 2: The partitioned corneal implantation microlens provided in Example 11;

[0103] Each experimental group was numbered according to the partitioned corneal implantation microlens provided in the corresponding embodiments.

[0104] I. Aging Test

[0105] The corneal microlenses were aged at 60°C, and samples were taken at 1, 3, 5, 8 and 12 months. The content of ultraviolet blocking agent was measured by spectral analysis to evaluate the aging of the microlenses.

[0106] II. Transparency, Biocompatibility and Sustained Antibiotic Release Tests

[0107] The duration of antibiotic release and the transparency of the microlenses were investigated.

[0108] 1. Test materials:

[0109] 1) Sixteen rabbits were used in the experiment;

[0110] 2) Physiological saline, lidocaine hydrochloride, surgical instruments, slit lamp, ophthalmic B-ultrasound, etc.

[0111] 3) Main equipment: surgical microscope, facial opening device, ophthalmic separator, implanter, sling, etc.

[0112] 2. Experimental process

[0113] The operated eyes of the experimental rabbits were cleaned before surgery. A corneal stromal capsule was prepared using a scalpel. After separating the capsule with a separator, a microlens was pushed into the capsule and centered using a surgical implanter. Dexamethasone eye drops were applied postoperatively.

[0114] Postoperative observation was continued, with antibiotic test results recorded at 8, 12, 18 and 24 hours postoperatively, and transparency was finally recorded at 12 months postoperatively.

[0115] 3. Transparency Scoring Criteria

[0116] 4. Test Results

[0117] 4.1 Aging Status Record

[0118] The results of this experiment show that neither experimental group 1 nor experimental group 2 showed premature aging of the materials.

[0119] 4.2 Transparency and Antibiotic Release Records

[0120] (1) The corneal transparency score at 12 months post-surgery is as follows:

[0121] The results of this experiment show that the corneal transparency of each group was basically the same 12 months after surgery.

[0122] (2) Antibiotic release test results:

[0123] The results of this experiment show that tobramycin was detected in both experimental group 1 and experimental group 2 at 2-8-12 hours. Tobramycin was not detected in experimental group 1 starting at 18 hours after the operation, while it was still detectable in experimental group 2.

[0124] 5. Experimental Conclusions

[0125] The results of this experiment show that no premature aging was observed in group 2, indicating good biocompatibility. The antibiotic release test results show that when the materials used in preparation were group 2 (i.e., "hydroxyethyl methacrylate, methyl methacrylate, and 4-propenoxy-2-hydroxybenzophenone" as described in Example 11), the tobramycin release time of the microlens could exceed 18 hours. Therefore, the material in group 2 is superior.

[0126] Example 14

[0127] This embodiment illustrates several components of the hydration solution and / or preservation solution in a method for preparing a partitioned corneal implantable microlens containing antibiotics, and selects a preferred hydration solution through comparison. Details are as follows:

[0128] The components of the hydration solution and / or preservation solution in this embodiment were prepared and tested according to the following test groups.

[0129] Experimental group 1: Contains tobramycin;

[0130] Experimental group 2: Contains tobramycin, bFGF, and vitamin B2;

[0131] Experimental group 3: No additives (blank control).

[0132] Following the use of the partitioned corneal implantation microlenses (9 in total) provided in Example 11, based on the composition of the hydrated solution described above, the postoperative recovery effect was evaluated after implantation into the cornea of ​​animals. Details are as follows:

[0133] Replace the components of the partitioned corneal implantation microlens provided in Example 11 in the hydrated solution with the corresponding components of the above-mentioned test groups. For parameters not recorded in each test group, please refer to Example 11.

[0134] I. Experimental Materials and Equipment

[0135] 1. Nine rabbits were used in the experiment;

[0136] 2. Reagents: physiological saline, lidocaine hydrochloride, etc.

[0137] 3. Main equipment: surgical microscope, facial opening device, ophthalmic separator, implanter, sling, ophthalmic B-ultrasound, slit lamp, etc.

[0138] II. Experimental Procedure

[0139] The operated eyes of the experimental rabbits were cleaned before surgery. A corneal stromal capsule was then prepared using a scalpel. After separating the capsule with a separator, a microlens was inserted into the capsule using a surgical implanter. Postoperatively, dexamethasone eye drops were administered according to the instructions. The rabbits were observed for 3 months postoperatively. Histological sections were taken at 3 months postoperatively to observe nerve growth.

[0140] Corneal transparency scoring criteria:

[0141] III. Test Results

[0142] 1. Corneal transparency observation record

[0143] The results showed that all experimental groups maintained complete transparency of the rabbit eyes after surgery, indicating that the corresponding components added to experimental groups 1 and 2 did not affect the transparency of the rabbit eyes after surgery.

[0144] 2. Observation and recording of nerve fiber growth

[0145] Slices showed that at 1 month post-surgery, the number of nerves exhibiting tortuosity and increased reflexivity in nerve plexus images had slightly decreased; this phenomenon significantly decreased at 3 months post-surgery, and the nerve plexus tended towards the pre-operative nerve morphology characteristics. Meanwhile, there was little difference between experimental groups 1 and 2, while the nerve recovery status of experimental group 3 was slightly lower than that of the other experimental groups. Therefore, it is evident that adding tobramycin during the hydration step, or simultaneously adding tobramycin, bFGF, and VB2 to the microlens, resulted in better post-operative outcomes.

[0146] It should be noted that the above description is merely a preferred embodiment in the specific implementation of this application, and is not intended to limit the technical solution protected by this application. Any equivalent substitutions or modifications made by those skilled in the art to the inventive concept of the technical solution disclosed in this application should be included within the protection scope of this application.

Claims

1. A zoned micro-lens for a corneal implant, the micro-lens being circularly curved, the micro-lens comprising two zones, characterized in that: The two regions are the first correction zone and the plano zone, respectively. The plano zone is surrounded by the first correction zone. The first correction zone and the plano zone are concentric. The first correction zone has the function of correcting vision. The refractive power of the plano zone is 0D.

2. The zoned corneal implant micro-lens of claim 1, wherein: The flat area has through holes.

3. The microlens for partitioned corneal implantation according to claim 2, characterized in that: The flat light area includes a second correction area, which is circular. The cross-section of the second correction area along the center of the circular curvature is a concave lens cross-section. The second correction area is surrounded by the remaining flat light area of ​​the flat light area.

4. The segmented corneal implantation microlens according to claim 2, characterized in that: The first correction zone has the function of correcting vision loss caused by an unhealthy state of the refractive media, and the second correction zone has the function of correcting vision loss caused by refractive error.

5. The segmented corneal implantation microlens according to claim 3, characterized in that: The number of through holes is one, the through hole is circular and concentric with the second correction area, and the second correction area is concentric with the flat area.

6. The segmented corneal implantation microlens according to claim 3, characterized in that: The cross section of the first correction zone along the direction of the center of the annular curvature is the cross section of a convex lens.

7. The segmented corneal implantation microlens according to claim 6, characterized in that: The optical center of the concave lens is a through hole, and the diameter of the through hole is 0.01 to 0.6 mm.

8. The microlens for partitioned corneal implantation according to claim 1, characterized in that: The diameter of the microlens is 2.5–5.5 mm; the thickness of the microlens is 25–63 μm.

9. The segmented corneal implantation microlens according to claim 1, characterized in that: The segmented corneal implantation microlens has the function of blocking ultraviolet light transmission.

10. The use of the partitioned corneal implantation microlens according to any one of claims 1 to 9 in products for correcting vision loss caused by unhealthy refractive media and in products for correcting vision loss caused by refractive errors.

11. The use of any one of claims 1 to 9 in products for correcting vision loss caused by unhealthy refractive media or in products for correcting vision loss caused by refractive errors.

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