Proline derivative, and pharmaceutical composition thereof and use thereof

Abstract

The present disclosure relates to a proline derivative, and a pharmaceutical composition thereof and the use thereof, and belongs to the technical fields of chemistry and medicine.

Description

Proline derivatives and their pharmaceutical compositions and uses

[0001] This application claims priority to the following earlier applications:

[0002] The full text of the aforementioned prior application is incorporated herein by reference. Technical Field

[0003] This disclosure relates to proline derivatives, pharmaceutical compositions thereof, and uses, and belongs to the field of chemical and pharmaceutical technology. Background Technology

[0004] Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid polypeptide that, along with GLP-1, belongs to the two major endogenous insulins in the human body. It is secreted by K cells in the duodenal and jejunal intestinal mucosa of the small intestine. Dietary nutrients such as carbohydrates and fats are effective stimulants for human GIP secretion. The GIP receptor GIPR (glucose-dependent insulinotropic polypeptide receptor) belongs to the B1 subfamily of the G protein-coupled receptor (GPCR) superfamily. It consists of an extracellular N-terminus, an intracellular C-terminus, and seven transmembrane domains, and is highly expressed in pancreatic B cells. Activation of GIPR triggers an insulinotropic response. GIPR binds to its ligand GIP, which in turn binds to Gsα (the activating α subunit of G protein), inducing adenylate cyclase activation and increasing cytoplasmic cAMP (cyclic adenosine monophosphate) levels. Increased cAMP levels can cause the regulatory subunit of PKA (protein kinase A) to dissociate from its catalytic subunit, translocate to the nucleus, and promote CREB phosphorylation. This leads to increased GH (insulin-induced hypoglycemic growth hormone) expression, stimulating insulin production and lowering blood glucose. Conversely, when blood glucose levels are low, GIPR activation can enhance the effects of glucagon, increasing glucagon secretion and raising blood glucose levels to regulate blood sugar.

[0005] The physiological functions of GIP are not limited to regulating insulin secretion; it also participates in a variety of other physiological processes. For example, GIP can promote fat synthesis in adipocytes and inhibit fat breakdown, thereby affecting energy storage and metabolism. Furthermore, GIP has shown protective effects on the cardiovascular system, improving cardiomyocyte function and reducing damage after myocardial infarction.

[0006] Therefore, it is urgent to conduct in-depth research on the biological characteristics of GIP and its receptor, and to develop new drugs with good activity. Summary of the Invention

[0007] To address the aforementioned technical problems, the first set of solutions provided in this disclosure consists of: compounds represented by formula (I), their stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts:

[0008] in,

[0009] X 1 X 5 They are either the same or different, and are selected independently from CH, C, and N;

[0010] X 2 X 3 X 4 Same or different, selected independently from CR 1 R 2 NR 3 and N;

[0011] R 1 and R 2 They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups, C 3-20 Cycloalkyloxy, C 1-20 Alkyloxy, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, 3-20 membered heterocyclic oxy group;

[0012] R 3 Selected from H, unsubstituted or optionally substituted groups: C 1-20 Alkyl, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups;

[0013] Or, when present, R on the same atom 1 and R 2 Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups;

[0014] Or, when present, R on different atoms 1 R 2 R 3The two atoms bonded to it together form the following unsubstituted or optionally substituted groups: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups;

[0015] Each The same or different, independently representing single or double bonds, are conditions that are related to... The bonded groups conform to the valence bond rule;

[0016] Y 1 Selected from O, S and NH;

[0017] A is selected from C 6-20 Aryl, C 3-20 Cycloalkyl, 3-20 membered heterocyclic, 3-20 membered heteroaryl, wherein, when present, the atom in A bonded to the NH on the left or the B on the right is C or N;

[0018] Each R a Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14(OR) 15 );

[0019] B is selected from C. 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 6-20 Aryl, C 3-20 Cycloalkyl, 3-20 membered heterocyclic, 3-20 membered heteroaryl, wherein when present, the atom in B bonded to the left-hand group A is C or N;

[0020] Each R b Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0021] Or, when they exist, two R a Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic;

[0022] Or, when they exist, two R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic;

[0023] Or, when it exists, R a R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic;

[0024] Y 2 Selected from O, S and NH;

[0025] C is selected from C 6-20 Aryl, C 3-20 Cycloalkyl, 3-20 membered heterocyclic, 3-20 membered heteroaryl;

[0026] Each R c Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(=O)R 4 -C(=O)OR 5 -OC(=O)R 6 -S(=O)(=NH)R 7-S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0027] Or, when they exist, two R c Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic;

[0028] R f1 R f2 Identical or different, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic;

[0029] R 4 R 5 R 6 R 7 R 8 R 9 R 10 R 11 R 12 R 13 R 14 R 15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 Aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2;

[0030] m, n, and p may be the same or different, and are independently selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.

[0031] According to embodiments in the context of this disclosure, when the group (C) 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 When described as "optionally substituted" or "substituted," it means that any of the groups can be replaced by one, two, or more groups selected from R. d The group is substituted.

[0032] According to the implementation scheme of this disclosure, each R d Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(=O)R d4 -C(=O)OR d5 -OC(=O)R d6 -S(=O)(=NH)R d7 -S(=O)2R d7 -S(=O)2OR d8 -OS(=O)2R d9 -B(OR) d10 (OR) d11 -P(=O)R d12 R d13 -P(O)(OR) d14 (OR) d15 );

[0033] Among them, R d4 R d5 R d6 R d7 R d8 R d9 R d10 R d11 R d12 R d13 R d14 R d15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 Aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2.

[0034] According to the implementation scheme of this disclosure, when each R d When replaced, it can be selected from one, two or more of R. e Substitution of groups;

[0035] Among them, each R e Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(=O)R e4 -C(=O)OR e5 -OC(=O)R e6 -S(=O)(=NH)R e7 -S(=O)2R e7 -S(=O)2OR e8 -OS(=O)2R e9 -B(OR) e10 (OR) e11 -P(=O)R e12 R e13 -P(O)(OR) e14 (OR) e15 );

[0036] Among them, R e4 R e5 R e6 R e7 R e8 R e9 Re10 R e11 R e12 R e13 R e14 R e15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 Aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2.

[0037] According to embodiments of this disclosure, the halogen is selected from F, Cl, Br or I.

[0038] According to the implementation scheme of this disclosure, X 1 X 5 They are either the same or different, and are selected independently from CH and N.

[0039] According to the implementation scheme of this disclosure, X 2 X 3 X 4 Same or different, selected independently from CR 1 R 2 NR 3 CR 1 and N;

[0040] R 1 and R 2 They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-12 Alkyl, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group, C 3-12 Cycloalkyloxy, C 1-12 Alkyloxy, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12Cycloalkynyloxy group, 3-12 membered heterocyclic oxy group;

[0041] R 3 Selected from H, unsubstituted or optionally substituted groups: C 1-12 Alkyl, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic groups;

[0042] Or, when present, R on the same atom 1 and R 2 Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic groups;

[0043] Or, when present, R on different atoms 1 R 2 R 3 The two atoms bonded to it together form the following unsubstituted or optionally substituted groups: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group.

[0044] According to the implementation scheme of this disclosure, each The same or different, independently representing single or double bonds, are conditions that are related to... The bonded groups conform to the valence bond rule. Preferably, One or two of them One is a double bond, the others are single bonds. For example, Selected from 1, 2, 3 or 4 selected from R 1 R 2 and R 3 The substituents replace the following groups: or Selected from 1, 2, 3 or 4 selected from R 1 R 2 and R 3 The substituents replace the following groups:

[0045] According to the implementation scheme of this disclosure, A is selected from C. 6-12 Aryl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic, 5-12 membered heteroaryl, such as phenyl (e.g. ), naphthyl, pyridyl (e.g.) ), pyrazinyl (e.g.) ), pyrimidine group (such as ), pyridazinyl (e.g.) ), cyclohexyl, piperidinyl, piperazinyl, quinolinyl, benzimidazolyl, benzothiophene, benzofuranyl, hexahydropyrimidinyl, hexahydropyridazinyl, 1,2-dihydropyridinyl (e.g. ), 1,4-dihydropyridyl, morpholinyl; or, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic, and 5-12 membered heteroaryl groups can be selected from bicyclic groups, such as fused rings, bridged rings, or spirocyclic groups, for example, spiro[3.3]heptyl (e.g. ), spiro[3,4]octyl (e.g. ), spiro[3.5]nonyl (e.g. ), spiro[4.4]nonyl (e.g. ), spiro[4.5]decyl (e.g. ), spiro[5.5]undecyl (e.g. ).

[0046] According to the implementation scheme of this disclosure, each R a Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR)11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0047] For example, each R a Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxetyl, oxetyl, oxetyl, -P(=O)(C) 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl group, -S(=O)2NH2, -COOH.

[0048] Or, according to another embodiment of this disclosure, each R a The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, C 3-6 Cycloalkyl, 3-6 membered heterocycloalkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-6 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-6 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-S-, C 3-6 cycloalkyl-S-, C 3-6 cycloalkyl-C 1-6 Alkyl-S-, C 1-6 Alkyl-3-6-membered heterocyclic group -S-,C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-6Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-6 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl)2、-COOH.

[0049] Or, according to another embodiment of this disclosure, each R a The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl)2、-COOH.

[0050] Or, according to another embodiment of this disclosure, each R aThe following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thioaziridine, tetrahydrofuranyl, pyrrolylyl, tetrahydropyranyl, piperidinyl, piperazine, morpholinyl, thiomorpholinyl, phenyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio. Methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylamino, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, =NH, =NCH3, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH.

[0051] According to the implementation scheme of this disclosure, B is selected from C. 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 6-12 Aryl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic, 5-12 membered heteroaryl, such as vinyl, ethynyl, propynyl, phenyl (e.g.) ), naphthyl, pyridyl (e.g.) ), pyrazinyl (e.g.) ), pyrimidine group (such as ), pyridazinyl (e.g.) ), quinolinyl, benzimidazolyl, benzothiophene, benzofuranyl, cyclohexyl, piperidinyl, piperazinyl, hexahydropyrimidinyl, hexahydropyridazinyl, 1,2-dihydropyridinyl (e.g. ), 1,4-dihydropyridyl, morpholinyl; or, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic, and 5-12 membered heteroaryl groups can be selected from bicyclic groups, such as fused rings, bridged rings, or spirocyclic groups, for example, spiro[3.3]heptyl (e.g. ), spiro[3,4]octyl (e.g. ), spiro[3.5]nonyl (e.g. ), spiro[4.4]nonyl (e.g. ), spiro[4.5]decyl (e.g. ), spiro[5.5]undecyl (e.g. ).

[0052] According to embodiments of this disclosure, B is selected from 5-12 heteroaryl groups, such as furanyl, thiophene, isoxazolyl, isothiazolyl, oxazolyl, thiazolyl, pyrazolyl, pyrroleyl, triazolyl, tetrazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyrazinyl, and pyridazinyl.

[0053] According to the embodiments of this disclosure, B can also be selected from 3-12 membered heterocyclic groups, for example...

[0054] According to the implementation scheme of this disclosure, each R b Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0055] For example, each R bIdentical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxetyl, oxetyl, oxetyl, -P(=O)(C) 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl), S(=O)(=NH)C 1-6 Alkyl group, -S(=O)2NH2, -COOH.

[0056] Or, according to another embodiment of this disclosure, each R b The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, C 3-6 Cycloalkyl, 3-6 membered heterocycloalkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-6 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-6 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-S-, C 3-6 cycloalkyl-S-, C 3-6 cycloalkyl-C 1-6 Alkyl-S-, C 1-6 Alkyl-3-6-membered heterocyclic group -S-,C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-6 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-6 Alkyl-C 3-6 cycloalkyl, -S(=O)2C1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl)2、-COOH.

[0057] Or, according to another embodiment of this disclosure, each R b The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl)2、-COOH.

[0058] Or, according to another embodiment of this disclosure, each R bThe following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thioaziridine, tetrahydrofuranyl, pyrrolylyl, tetrahydropyranyl, piperidinyl, piperazine, morpholinyl, thiomorpholinyl, phenyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propionyl, etc. Thio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropyl NH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, =NH, =NCH3, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH.

[0059] Alternatively, according to an embodiment of this disclosure, when present, two R a Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic groups, such as azircyclopentenyl, etc. For example

[0060] Alternatively, according to an embodiment of this disclosure, when present, two R a Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic groups, such as azircyclopentenyl, etc. For example

[0061] Alternatively, according to an embodiment of this disclosure, when present, two R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic groups, such as azircyclopentenyl, etc. For example

[0062] Alternatively, according to an embodiment of this disclosure, when present, two R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic groups, such as azircyclopentenyl, etc. For example

[0063] Alternatively, according to an embodiment of this disclosure, when present, R a R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 heteroaryl, 3-12 heterocyclic.

[0064] Alternatively, according to an embodiment of this disclosure, when present, R a R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic.

[0065] According to the implementation scheme of this disclosure, the combination schemes A and B are as follows:

[0066] According to the implementation scheme of this disclosure, the combination scheme of A and B can also be as follows:

[0067] According to the implementation scheme of this disclosure, Y 2 Selected from O, S and NH;

[0068] According to the implementation scheme of this disclosure, C is selected from C. 6-12 Aryl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic, 5-12 membered heteroaryl, such as phenyl (e.g. ), naphthyl, pyridyl (e.g.) ), pyrazinyl (e.g.) ), pyrimidine group (such as ), pyridazinyl (e.g.) ), quinolinyl, benzimidazolyl, benzothiophene, benzofuranyl, cyclohexyl, piperidinyl, piperazinyl, hexahydropyrimidinyl, hexahydropyridazinyl, 1,2-dihydropyridinyl (e.g. ), 1,4-dihydropyridyl, morpholinyl; or, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic, and 5-12 membered heteroaryl groups can be selected from bicyclic groups, such as fused rings, bridged rings, or spirocyclic groups, for example, spiro[3.3]heptyl (e.g. ), spiro[3,4]octyl (e.g. ), spiro[3.5]nonyl (e.g. ), spiro[4.4]nonyl (e.g. ), spiro[4.5]decyl (e.g. ), spiro[5.5]undecyl (e.g. );

[0069] Each R c Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(=O)R 4 -C(=O)OR 5 -OC(=O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9-B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0070] For example, each R c Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxecyclobutyl, oxecyclopentyl, oxecyclohexyl, morpholinyl, -P(=O)(C 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH;

[0071] Alternatively, according to an embodiment of this disclosure, when present, two R c Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 heteroaryl, 3-12 heterocyclic.

[0072] Or, according to another embodiment of this disclosure (I), each R c The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, C 3-6 Cycloalkyl, 3-6 membered heterocycloalkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-6 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-6 Alkyloxy, C 1-6Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-S-, C 3-6 cycloalkyl-S-, C 3-6 cycloalkyl-C 1-6 Alkyl-S-, C 1-6 Alkyl-3-6-membered heterocyclic group -S-,C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-6 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-6 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl group 2, -COOH;

[0073] Alternatively, according to an embodiment of this disclosure, when present, two R c Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic.

[0074] Or, according to another embodiment of this disclosure (I), each R cThe following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl)2、-COOH.

[0075] Or, according to another embodiment of this disclosure, each R c The following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxaziridine, thioaziridine, tetrahydrofuranyl, pyrrolylyl, tetrahydropyranyl, piperidinyl, piperazine, morpholinyl, 2,6-dimethylmorpholinyl, thiomorpholinyl, phenyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio. Ethylthio, propanethio, methylamino, ethylamino, propane, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, =NH, =NCH3, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH.

[0076] According to the implementation scheme of this disclosure, R f1 R f2 Identical or different, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 heteroaryl, 3-12 heterocyclic.

[0077] According to the implementation scheme of this disclosure, Rf1 R f2 Identical or different, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, phenyl, 5-6 membered heteroaryl, 3-6 membered heterocyclic.

[0078] According to the implementation scheme of this disclosure, R f1 R f2 Identical or different, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 2-4 alkenyl, C 2-4 alkynyl group, C 3-6 Cycloalkyl groups, 3-6 membered heterocyclic groups.

[0079] According to the implementation scheme of this disclosure, R f1 R f2 Identical or different, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl, vinyl, ethynyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxacyclobutyl, oxacyclopentyl, oxacyclohexyl.

[0080] According to the implementation scheme of this disclosure, R 4 R 5 R 6 R 7 R 8 R 9 R 10 R 11 R 12 R 13 R 14 R 15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 Aryloxy group, 5-12-membered heteroaryloxy group, 3-12-membered heterocyclic oxy group, NH2.

[0081] According to the implementation scheme of this disclosure, R 4 R 5 R 6 R 7 R 8 R 9 R 10 R 11 R 12 R 13 R 14 R 15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, C 6-6 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic, C 1-6 Alkyloxy, C 2-6 alkenyloxy group, C 2-6 alkynyloxy group, C 3-6 Cycloalkyloxy, C 3-6 Cycloalkenyloxy, C 3-6 Cycloalkynyloxy group, C 6-6 Aryloxy group, 5-6 membered heteroaryloxy group, 3-6 membered heterocyclic oxy group, NH2.

[0082] According to the implementation scheme of this disclosure, R 4 R 5 R 6 R 7 R 8 R 9 R 10 R 11 R 12 R 13 R 14 R 15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl, Halogenated C 2-6 Alkyl, C 1-6 Alkyloxy group, halogenated C 1-6Alkyloxy group.

[0083] According to the implementation scheme of this disclosure, R 4 R 5 R 6 R 7 R 8 R 9 R 10 R 11 R 12 R 13 R 14 R 15 They are the same or different, and are selected independently from H or C. 1-6 Alkyl (e.g., methyl).

[0084] According to the embodiments of this disclosure, m, n, and p may be the same or different, and are independently selected from 0, 1, 2, 3, 4, 5, or 6.

[0085] According to embodiments of this disclosure, the “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0086] According to embodiments of this disclosure, the compound represented by formula (I) has the following structure:

[0087] Among them, Y 1 Y 2 X 1 X 2 X 3 X 4 X 5 A, B, C, R a R b R c R f1 R f2 m, n, and p have the definitions described above.

[0088] According to embodiments of this disclosure, the compound represented by formula (I) has the following structure:

[0089] Among them, Y 1 Y 2 A, B, C, R a R b R c R f1 R f2 The definitions of m, n, and p are as above;

[0090] Each R g They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups, C 3-20 Cycloalkyloxy, C 1-20 Alkyloxy, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, 3-20 membered heterocyclic oxy group;

[0091] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups;

[0092] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups;

[0093] v can be the same or different, and can be independently selected from 0, 1, 2, 3, 4 or 5;

[0094] Each t1 and t2 may be the same or different, and is independently selected from 0, 1, 2, 3, 4 or 5.

[0095] According to the implementation scheme of this disclosure, each R g They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-12 Alkyl, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group, C 3-12 Cycloalkyloxy, C 1-12 Alkyloxy, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, 3-12 membered heterocyclic oxy group;

[0096] Or, when present, two R atoms on the same atomg Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic groups;

[0097] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group.

[0098] According to the implementation scheme of this disclosure, each R g They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl, C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, 3-6 membered heterocyclic, C 3-6 Cycloalkyloxy, C 1-6 Alkyloxy, C 3-6 Cycloalkyloxy, C 3-6 Cycloalkenyloxy, C 3-6 Cycloalkynyloxy group, 3-6 membered heterocyclic oxy group;

[0099] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalynyl, 3-6 membered heterocyclic groups;

[0100] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalynyl, 3-6 membered heterocyclic groups;

[0101] According to the embodiments of this disclosure, t1 and t2 may be the same or different, and are independently selected from 0, 1, 2 or 3.

[0102] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0103] Alternatively, according to another embodiment of this disclosure, each R gThe following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, C 3-6 Cycloalkyl, 3-6 membered heterocycloalkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-6 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-6 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-S-, C 3-6 cycloalkyl-S-, C 3-6 cycloalkyl-C 1-6 Alkyl-S-, C 1-6 Alkyl-3-6-membered heterocyclic group -S-,C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-6 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-6 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6Alkyl, -P(=O)(C 1-6 Alkyl group 2, -COOH;

[0104] Alternatively, according to another embodiment of this disclosure, each R g The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl group 2, -COOH;

[0105] Or, according to another embodiment of this disclosure, each R g The following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thioaziridine, tetrahydrofuranyl, pyrrolylyl, tetrahydropyranyl, piperidinyl, piperazine, morpholinyl, thiomorpholinyl, phenyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propionyl, etc. Thio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropyl NH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, =NH, =NCH3, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH.

[0106] According to embodiments of this disclosure, in compounds (II-1) to (XIV-3) described above, R g It can be located on a tertiary carbon atom adjacent to the N atom in the ring.

[0107] According to embodiments of this disclosure, in compounds (II-1) to (XIV-3) described above,

[0108] A is selected from the following groups that can be substituted: C6-10 Aryl, C 3-10 cycloalkyl, 3-10 membered heterocyclic, 5-10 membered heteroaryl;

[0109] B is selected from the following groups that can be substituted: C 2-6 alkynyl group, C 6-10 Aryl, C 3-10 cycloalkyl, 3-10 membered heterocyclic, 5-10 membered heteroaryl;

[0110] C is selected from the following groups that can be substituted: C 6-10 Aryl, C 3-10 cycloalkyl, 3-10 membered heterocyclic, 5-10 membered heteroaryl;

[0111] Y 1 Selected from O and S;

[0112] Y 2 Selected from O and S;

[0113] Each R a The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl group 2, -COOH;

[0114] Or, when they exist, two R a Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0115] Each R b The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl group 2, -COOH;

[0116] Or, when they exist, two R bTogether with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0117] Each R c The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C 3-6Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl group 2, -COOH;

[0118] Or, when they exist, two R c Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0119] Each R g The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl group 2, -COOH;

[0120] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, 3-6 membered heterocyclic groups;

[0121] Or, when present, two R atoms on the same atom g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0122] Or, when present, two R atoms on different atomsg Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, 3-6 membered heterocyclic groups;

[0123] Or, when present, two R atoms on different atoms g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0124] R f1 R f2 Identical or different, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl, vinyl, ethynyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxetyl, oxetyl, oxetyl;

[0125] Each m, n, p, v, t1, t2 is the same or different, and is independently selected from 0, 1, 2, or 3.

[0126] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0127] According to embodiments of this disclosure, in compounds (II-1) to (XIV-3) described above,

[0128] A is selected from the following groups that can be substituted: C 6-10 Aryl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic, 5-6 membered heteroaryl;

[0129] B is selected from the following groups that can be substituted: C 2-6 alkynyl group, C 6-10 Aryl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic, 5-6 membered heteroaryl;

[0130] C is selected from the following groups that can be substituted: C 6-10 Aryl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic, 5-6 membered heteroaryl.

[0131] According to embodiments of this disclosure, in compounds (II-1) to (XIV-3) described above,

[0132] A is selected from the following groups that are optionally substituted: phenyl, naphthyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyridin-2(1H)-one;

[0133] B is selected from the following optionally substituted groups: phenyl, naphthyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyridin-2(1H)-one, Ethynyl, spiro[3.3]heptyl, spiro[3.4]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl,

[0134] Alternatively, B is selected from furanyl, thiophenyl, isoxazolyl, isothiazolyl, oxazolyl, thiazolyl, pyrazolyl, pyrroleyl, triazolyl, tetrazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyrazinyl, and pyridazinyl.

[0135] C is selected from the following optionally substituted groups: phenyl, naphthyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyridin-2(1H)-keto, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, Cyclohexyl, piperidinyl.

[0136] According to embodiments of this disclosure, in compounds (II-1) to (XIV-3) described above,

[0137] A is selected from the following groups that can be substituted:

[0138] B is selected from the following groups that can be substituted: Of the above groups, the right half contains This indicates that an R is connected to the right end. b ;

[0139] Alternatively, B may be selected from the following groups that can be substituted: Of the above groups, the right half contains This indicates that an R is connected to the right end. b ;

[0140] C is selected from the following groups that can be substituted: Of the above groups, the right half contains This indicates that an R is connected to the right end. c .

[0141] According to embodiments of this disclosure, in compounds (II-1) to (XIV-3) described above,

[0142] A is selected from the following groups that can be substituted:

[0143] B is selected from the following groups that can be substituted: Of the above groups, the right half contains This indicates that an R is connected to the right end. b ;

[0144] C is selected from the following groups that can be substituted: Of the above groups, the right half contains This indicates that an R is connected to the right end. c .

[0145] According to embodiments of this disclosure, in compounds (II-1) to (XIV-3) described above,

[0146] The combination schemes of A and B are as follows:

[0147] In the above group combination, the right half contains This indicates that an R is connected to the right end. b .

[0148] According to embodiments of this disclosure, in compounds (II-1) to (XIV-3) described above,

[0149] Each R aThe following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolylyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino. Propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropyl NH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0150] Each R b The following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolylyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino. Dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylamino, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2NHCF3, -S(=O)2N(CH3)2, =NH, =NCH3, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH,

[0151] Each R cThe following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolylyl, piperidinyl, morpholinyl, 2,6-dimethylmorpholinyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamine. , ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylamino, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2NHCF3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0152] Each R g The following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolylyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino , isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylamino, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, =NH, =NCH3, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0153] Or, when present, two R atoms on the same atom gTogether with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl groups, 3-6 membered heterocyclic groups;

[0154] Or, when present, two R atoms on the same atom g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0155] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl groups, 3-6 membered heterocyclic groups;

[0156] Or, when present, two R atoms on different atoms g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0157] According to embodiments of this disclosure, in compounds (II-1) to (XIV-3) described above,

[0158] Each R a The following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, are unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopropylamino, aziridine, oxaziridine, thionidine, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -COOH;

[0159] Each R bThe following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, ... Dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylamino, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2NHCF3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH,

[0160] Each R c The following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolylyl, piperidinyl, morpholinyl, 2,6-dimethylmorpholinyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamine. , propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylamino, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, =NH, =NCH3, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0161] Each R gThe following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxaziridine, thiocyclobutyl, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -COOH;

[0162] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl groups, 3-6 membered heterocyclic groups;

[0163] Or, when present, two R atoms on the same atom g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0164] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl groups, 3-6 membered heterocyclic groups;

[0165] Or, when present, two R atoms on different atoms g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0166] According to embodiments of this disclosure, the compound represented by formula (I) has the following structure:

[0167] Among them, Y 1 Y 2 R a R b R c R gThe definitions of m, n, p, and v are as above;

[0168] R h Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0169] R i Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(=O)R 4 -C(=O)OR 5 -OC(=O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0170] U 1 U 8 U 9 They are either the same or different, and are selected independently from CH and N;

[0171] U 2 —U 3 "Selected from the following groups:"

[0172] U 4 —U 5 "Selected from the following groups:"

[0173] U 6 —U 7 "Selected from the following groups:"

[0174] Each t1 and t2 may be the same or different, and is independently selected from 0, 1, 2, 3, 4 or 5.

[0175] According to the implementation scheme of this disclosure, R h Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0176] For example, R h Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxetyl, oxetyl, oxetyl, -P(=O)(C) 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH;

[0177] For example, R h Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, SF3, SF5, and the following groups, either unsubstituted or optionally substituted: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, oxacyclobutyl, oxacyclopentyl, oxacyclohexyl, -P(=O)(CH3)2, -C(=O)CH3, -S(=O)(=NH)CH3, S(=O)2NH2, -COOH.

[0178] Alternatively, according to another embodiment of this disclosure, R h Selected from H, halogens, CN, OH, SH, NH2, SF3, SF5, and the following groups with no or optional substitution: C 1-6 Alkyl, C 3-6 Cycloalkyl, 3-6 membered heterocycloalkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-6 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-6 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-S-, C 3-6 cycloalkyl-S-, C 3-6 cycloalkyl-C 1-6 Alkyl-S-, C 1-6 Alkyl-3-6-membered heterocyclic group -S-,C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-6 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-6 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2、-N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C1-6 Alkyl)2、-COOH.

[0179] Alternatively, according to another embodiment of this disclosure, R h Selected from H, halogens, CN, OH, SH, NH2, SF3, SF5, and unsubstituted or optionally substituted groups of the following: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiohexacyclobutyl, tetrahydrofuranyl, pyrrolylyl, tetrahydropyranyl, piperidinyl, piperazine, morpholinyl, thiomorpholinyl, phenyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamine , propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropyl NH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH.

[0180] According to the implementation scheme of this disclosure, R h Selected from the following groups that are substituted or optionally substituted: C 1-6 Alkyl-NH-S(=O)2-, Halogenated C 1-6 Alkyl-NH-S(=O)2-, C 1-6 Alkyl NH-C(O)-, (C 1-6 alkyl)2N-C(O)-、 For example, R h Selected from CF3-NH-S(=O)2-,

[0181] According to the implementation scheme of this disclosure, R h and adjacent R b Together with adjacent atoms, they form the following groups that are unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic;

[0182] For example, R h and adjacent R bTogether with adjacent atoms, they form the following groups that are unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0183] For example, R h and adjacent R b Together with adjacent atoms, they form unsubstituted or optionally substituted groups such as: azircyclopentenyl, e.g. For example, R h and adjacent R b Together with adjacent atoms, they form the following groups that are unsubstituted or optionally substituted:

[0184] According to the implementation scheme of this disclosure, R i Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(=O)R 4 -C(=O)OR 5 -OC(=O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0185] For example, R i Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), C 3-6 Cycloalkyl groups (e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl), 3-6 membered heterocyclic groups (e.g., aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine), -P(=O)(C 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH;

[0186] For example, R i Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), C 3-6 Cycloalkyl groups (e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl), 3-6 membered heterocyclic groups (e.g., aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine), -P(=O)(C 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl group, -S(=O)2NH2, -COOH.

[0187] Or, according to another embodiment of this disclosure, R i Selected from H, halogens, OH, SH, NH2, SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl, C 3-6 Cycloalkyl, 3-6 membered heterocycloalkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-6 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-6Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-S-, C 3-6 cycloalkyl-S-, C 3-6 cycloalkyl-C 1-6 Alkyl-S-, C 1-6 Alkyl-3-6-membered heterocyclic group -S-,C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-6 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-6 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2、-N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl)2、-COOH.

[0188] Or, according to another embodiment of this disclosure, R i Selected from H, halogens, OH, SH, NH2, SF3, SF5, C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2、-N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl)2、-COOH.

[0189] Or, according to another embodiment of this disclosure, R iSelected from H, halogens, CN, OH, SH, NH2, SF3, SF5, and unsubstituted or optionally substituted groups of the following: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thioheridine, tetrahydrofuranyl, pyrrolylyl, tetrahydropyranyl, piperidinyl, piperazine, morpholinyl, 2,6-dimethylmorpholinyl, thiomorpholinyl, phenyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino. , Ethylamino, Propylamino, Isopropylamino, Dimethylamino, Diethylamino, Dipropylamino, Diisopropylamino, CyclopropylNH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH.

[0190] Or, according to another embodiment of this disclosure, R i and adjacent R c Together with adjacent atoms, they form the following groups that are unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic;

[0191] For example, R i and adjacent R c Together with adjacent atoms, they form the following groups that are unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic.

[0192] According to the embodiments of this disclosure, each t1 and t2 may be the same or different, and is independently selected from 0, 1, 2 or 3.

[0193] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0194] According to embodiments of this disclosure, the above-mentioned (XI-1) to (X-XVIVI-3) compounds have the following structures:

[0195] Y 1 Selected from O and S;

[0196] Y 2 Selected from O and S;

[0197] U 1 U 8 U 9 They are either the same or different, and are selected independently from CH and N;

[0198] U 2 —U 3 "Selected from the following groups:"

[0199] U 4 —U 5 "Selected from the following groups:"

[0200] U 6 —U 7 "Selected from the following groups:"

[0201] Each R a Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxetyl, oxetyl, oxetyl, -P(=O)(C) 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH;

[0202] Each R b Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxetyl, oxetyl, oxetyl, -P(=O)(C) 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl), S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH;

[0203] Each R c Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxecyclobutyl, oxecyclopentyl, oxecyclohexyl, morpholinyl, -P(=O)(C 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH;

[0204] Each R g They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl, C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, 3-6 membered heterocyclic, C 3-6 Cycloalkyloxy, C 1-6 Alkyloxy, C 3-6 Cycloalkyloxy, C 3-6 Cycloalkenyloxy, C 3-6 Cycloalkynyloxy group, 3-6 membered heterocyclic oxy group;

[0205] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalynyl, 3-6 membered heterocyclic groups;

[0206] Or, when present, two R atoms on different atomsg Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalynyl, 3-6 membered heterocyclic groups;

[0207] R h Selected from SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxetyl, oxetyl, oxetyl, -P(=O)(C) 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl), S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH;

[0208] R i Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), C 3-6 Cycloalkyl groups (e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl), 3-6 membered heterocyclic groups (e.g., aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine), -P(=O)(C 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH;

[0209] Each m, n, p, v, t1, t2 is the same or different, and is independently selected from 0, 1, or 2.

[0210] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0211] According to embodiments of this disclosure, the above-mentioned (XI-1) to (X-XVIVI-3) compounds have the following structures:

[0212] Y 1Selected from O and S;

[0213] Y 2 Selected from O and S;

[0214] U 1 U 8 U 9 They are either the same or different, and are selected independently from CH and N;

[0215] U 2 —U 3 "Selected from the following groups:"

[0216] U 4 —U 5 "Selected from the following groups:"

[0217] U 6 —U 7 "Selected from the following groups:"

[0218] Each R a The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl group 2, -COOH;

[0219] Or, when they exist, two R a Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0220] Each R b The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl group 2, -COOH;

[0221] Or, when they exist, two Rb Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0222] Each R c The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl group 2, -COOH;

[0223] Or, when they exist, two R c Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0224] Each R g The following groups, whether identical or different, are independently selected from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2, =NH, =NC 1-6 Alkyl, -N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl group 2, -COOH;

[0225] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, 3-6 membered heterocyclic groups;

[0226] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, 3-6 membered heterocyclic groups;

[0227] R hSelected from H, halogens, CN, OH, SH, NH2, SF3, SF5, and the following groups with no or optional substitution: C 1-6 Alkyl, C 3-6 Cycloalkyl, 3-6 membered heterocycloalkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-6 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-6 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-S-, C 3-6 cycloalkyl-S-, C 3-6 cycloalkyl-C 1-6 Alkyl-S-, C 1-6 Alkyl-3-6-membered heterocyclic group -S-,C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-6 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-6 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2、-N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl group 2, -COOH;

[0228] Or, R h and adjacent R b Together with adjacent atoms, they form the following groups that are unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0229] R i Selected from H, halogens, OH, SH, NH2, SF3, SF5, C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 6-10 Aryl, 5-6 quinone heteroaryl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 cycloalkyl, -S(=O)2C 1-6 Alkyl group, -S(=O)2C 3-6 cycloalkyl, -S(=O)2C 1-3 Alkyl-C 3-6Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2, -S(=O)2NH2, -S(=O)2NH(C 1-6 Alkyl), -S(=O)2N(C 1-6 Alkyl)2、-N=S(=O)(C 1-6 Alkyl)2、-S(=O)(=NH)C 1-6 Alkyl, -S(=O)(=NC 1-6 Alkyl)C 1-6 Alkyl group, -S(=O)(=N-CN)C 1-6 Alkyl, -P(=O)(C 1-6 Alkyl group 2, -COOH;

[0230] Or, R i and adjacent R c Together with adjacent atoms, they form the following groups that are unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0231] Each m, n, p, v, t1, t2 is the same or different, and is independently selected from 0, 1, or 2.

[0232] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0233] According to embodiments of this disclosure, the above-mentioned (XI-1) to (X-XVIVI-3) compounds have the following structures:

[0234] Y 1 Selected from O and S;

[0235] Y 2 Selected from O and S;

[0236] U 1 U 8 U 9 They are either the same or different, and are selected independently from CH and N;

[0237] U 2 —U 3 "Selected from the following groups:"

[0238] U 4 —U 5 "Selected from the following groups:"

[0239] U6 —U 7 "Selected from the following groups:"

[0240] Each R a The following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolylyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino. Propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropyl NH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0241] Each R b The following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolylyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino , isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylamino, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, =NH, =NCH3, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0242] Each R c The following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolylyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethyl... Amino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropyl NH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0243] Each R g The following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolylyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino , isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylamino, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, =NH, =NCH3, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0244] Or, when present, two R atoms on the same atomg Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl groups, 3-6 membered heterocyclic groups;

[0245] Or, when present, two R atoms on the same atom g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0246] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl groups, 3-6 membered heterocyclic groups;

[0247] Or, when present, two R atoms on different atoms g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0248] R h Selected from H, halogens, CN, OH, SH, NH2, SF3, SF5, and unsubstituted or optionally substituted groups of the following: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolylyl, piperidinyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino Amino, dipropylamino, diisopropylamino, cyclopropyl NH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2NHCF3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH,

[0249] R iSelected from H, halogens, CN, OH, SH, NH2, SF3, SF5, with no substitution or optional substitution of the following groups: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolylyl, piperidinyl, morpholinyl, 2,6-dimethylmorpholinyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino. Isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylamino, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0250] Or R i and adjacent R c Together with adjacent atoms, they form the following groups that are unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0251] Each m, n, p, v, t1, t2 is the same or different, and is independently selected from 0, 1, or 2.

[0252] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0253] According to embodiments of this disclosure, the above-mentioned (XI-1) to (X-XVIVI-3) compounds have the following structures:

[0254] Y 1 Selected from O and S;

[0255] Y 2 Selected from O and S;

[0256] U 1 U 8 U 9 They are either the same or different, and are selected independently from CH and N;

[0257] U 2 —U 3 "Selected from the following groups:"

[0258] U 4 —U 5 "Selected from the following groups:"

[0259] U 6 —U 7 "Selected from the following groups:"

[0260] Each R a The following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, are unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopropylamino, aziridine, oxaziridine, thionidine, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -COOH;

[0261] Each R b The following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino. Isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylamino, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0262] Each R cThe following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, and unsubstituted or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino. Dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylamino, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, =NH, =NCH3, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0263] Each R g The following groups, selected independently from H, halogen, OH, SH, NH2, cyano, nitro, oxo (=O), thio (=S), SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxaziridine, thiocyclobutyl, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -COOH;

[0264] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl groups, 3-6 membered heterocyclic groups;

[0265] Or, when present, two R atoms on the same atom g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0266] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl groups, 3-6 membered heterocyclic groups;

[0267] Or, when present, two R atoms on different atoms g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0268] R h Selected from H, halogens, CN, OH, SH, NH2, SF3, SF5, and unsubstituted or optionally substituted groups of the following: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino Diisopropylamino, Cyclopropyl NH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2NHCF3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH,

[0269] R iSelected from H, halogens, CN, OH, SH, NH2, SF3, SF5, and unsubstituted or optionally substituted groups of the following: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolylyl, piperidinyl, morpholinyl, 2,6-dimethylmorpholinyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, di... Methylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylamino, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0270] Or R i and adjacent R c Together with adjacent atoms, they form the following groups that are unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0271] Each m, n, p, v, t1, t2 is the same or different, and is independently selected from 0, 1, or 2.

[0272] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0273] According to embodiments of this disclosure, the above-mentioned (XI-1) to (X-XVIVI-3) compounds have the following structures:

[0274] Y 1 Selected from O and S;

[0275] Y 2 Selected from O and S;

[0276] U 1 U 8 U 9 They are either the same or different, and are selected independently from CH and N;

[0277] U 2 —U 3 "Selected from the following groups:"

[0278] U 4 —U 5 "Selected from the following groups:"

[0279] U 6 —U 7 "Selected from the following groups:"

[0280] Each R a The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -COOH;

[0281] Each R b The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, and without or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino. Diethylamino, dipropylamino, diisopropylamino, cyclopropyl NH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0282] Each R cThe following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, whether identical or different, and unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino Dipropylamino, diisopropylamino, cyclopropyl NH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, =NH, =NCH3, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0283] Each R g The following groups, selected independently from H, halogen, OH, NH2, cyano, oxo (=O), thio (=S), SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxaziridine, thiocyclobutyl, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -COOH;

[0284] Or, when present, two R atoms on the same atom g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0285] Or, when present, two R atoms on different atoms g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0286] R h Selected from H, halogens, CN, OH, NH2, SF3, SF5, and unsubstituted or optionally substituted groups of the following: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, di... Isopropylamine group, cyclopropyl NH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2NHCF 3. -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH,

[0287] R i Selected from H, halogens, CN, OH, NH2, SF3, SF5, and unsubstituted or optionally substituted groups of the following: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolylyl, piperidinyl, morpholinyl, 2,6-dimethylmorpholinyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethyl... Amino, diethylamino, dipropylamino, diisopropylamino, cyclopropyl NH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH;

[0288] Each m, n, p, v, t1, t2 is the same or different, and is independently selected from 0, 1, or 2.

[0289] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0290] According to embodiments of this disclosure, the above-mentioned (XI-1) to (X-XVIVI-3) compounds, R g It can be located on a tertiary carbon atom adjacent to the N atom in the ring.

[0291] According to embodiments of this disclosure, the above-mentioned compounds (XI-1) to (XI-3), (X-VIII-1) to (X-VIII-3), (X-IX-1) to (X-IX-3), (XX-1) to (XX-3), (X-XI-1) to (X-XI-3), (X-XII-1) to (X-XII-3), (X-XIII-1) to (X-XIII-3), (X-XVI-1) to (X-XVI-3), and (X-XVII-1) to (X-XVII-3) have the following structures:

[0292] Among them, fragments The following structures are selected from those with optional substitution:

[0293] Y 1 Y 2 U 1 U 2 U 3 U 4 U 5 U 6 U 7 U 8 U 9 R a R b R c R g R h R i The definitions of m, n, p, and v are as above;

[0294] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0295] According to embodiments of this disclosure, the above-mentioned (X-III-1) to (X-III-3), (X-XVIVI-1) to (X-XVIVI-3) compounds have the following structures:

[0296] Among them, fragments The following structures are selected from those with optional substitution:

[0297] Y1 Y 2 U 1 U 2 U 3 U 4 U 5 U 6 U 7 U 8 U 9 R a R b R c R g R h R i The definitions of m, n, p, and v are as above;

[0298] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0299] According to embodiments of this disclosure, the above-mentioned (XI-1) to (X-XVIVI-3) compounds have the following structures:

[0300] Among them, Y 1 Y 2 U 1 U 2 U 3 U 4 U 5 U 6 U 7 U 8 U 9 R a R b R c R g R h The definitions of m, n, p, and v are as above;

[0301] R i Selected from SF3, SF5, and the following groups, either unsubstituted or optionally substituted: 3-6 membered heterocyclic groups (e.g., azirrobutyl, azirropentyl, piperidinyl, oxacyclobutyl, oxacyclopentyl, oxacyclohexyl, morpholinyl), -P(=O)(C 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl group, -S(=O)2NH2.

[0302] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0303] According to embodiments of this disclosure, in the above-mentioned (X-XII-1) to (X-XIII-3) compounds, when Rb When R is a substituent group on S or P in the ring, b Selected from oxo (=O), and the following groups that are unsubstituted or optionally substituted: =NH, =NC 1-6 Alkyl, =NC 3-6 cycloalkyl, =NC(O)C 1-6 Alkyl group, =NS(=O)2C 1-6 Alkyl, C 1-6 Alkyl, C 3-6 cycloalkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, C 1-6 Alkyl-NH-, C 3-6 cycloalkyl-NH-, (C 1-6 alkyl)2N-, (C 3-6 2N-cycloalkyl.

[0304] According to embodiments of this disclosure, in the above-mentioned (X-XII-1) to (X-XIII-3) compounds, when R b When R is a substituent group on S or P in the ring, b Selected from oxo (=O), and the following groups, unsubstituted or optionally substituted: =NH, =NCH3, =Ncyclopropyl, =NC(O)CH3, =NS(=O)2CH3, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-.

[0305] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0306] According to embodiments of this disclosure, the compound represented by formula (I) has the following structure:

[0307] Where Y 1 Selected from O; Y 2 Selected from O;

[0308] U 1 Selected from CH and N;

[0309] U 8 Selected from CH and N;

[0310] U 9 Selected from CH and N;

[0311] U 2 —U3 "Selected from the following groups:"

[0312] U 4 —U 5 "Selected from the following groups:"

[0313] U 6 —U 7 "Selected from the following groups:"

[0314] Each R a The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either identical or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0315] Or, when they exist, two R aTogether with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 Cycloalkyl, C6 aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0316] Each R b The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either identical or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0317] Or, when they exist, two R b Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 Cycloalkyl, C6 aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0318] Each R cThe following groups, which may be identical or different and independently selected from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0319] Or, when they exist, two R c Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 Cycloalkyl, C6 aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0320] Each R g The following groups, which may be identical or different and independently selected from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 Cycloalkyl-NH-,-C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0321] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl groups, 3-6 membered heterocyclic groups;

[0322] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, 3-6 membered heterocyclic groups;

[0323] R h Selected from -COOH,

[0324] R i Selected from H, halogens, CN, OH, NH2, SF3, SF5, C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2;

[0325] Each m, n, p, v is the same or different, and is independently selected from 0, 1, or 2.

[0326] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0327] According to embodiments of this disclosure, in the (X-III-3) or (X-XVIVI-2) compound, each R aThe following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -COOH.

[0328] According to embodiments of this disclosure, in the (X-III-3) or (X-XVIVI-2) compound, each R b The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -COOH.

[0329] According to embodiments of this disclosure, in the (X-III-3) or (X-XVIVI-2) compound, each R c The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -COOH;

[0330] Or, when they exist, two R c Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 4-6Cycloalkyl, phenyl, furanyl, thiophene, pyrrolyl, pyrazolyl, triazolyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, dihydrofuranyl, dihydrothiophene, dihydropyrrolyl, dihydropyranyl.

[0331] According to embodiments of this disclosure, in the (X-III-3) or (X-XVIVI-2) compound, each R g The following groups, selected independently from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, aziridine, oxaziridine, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -COOH;

[0332] Or, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, oxetyl, thiohexacyclobutyl, aziridine, oxetyl, and aziridine;

[0333] Or, when present, two R atoms on different atoms g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0334] According to embodiments of this disclosure, in (X-III-3) or (X-XVIVI-2) compounds, R h Selected from -COOH.

[0335] According to embodiments of this disclosure, in (X-III-3) or (X-XVIVI-2) compounds, R iSelected from H, halogen, CN, OH, NH2, SF3, SF5, and unsubstituted or optionally substituted of the following groups: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, oxaziridine, thioaziridine, tetrahydrofuranyl, pyrrolylyl, piperidinyl, morpholinyl, 2,6-dimethylmorpholinyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2.

[0336] According to embodiments of this disclosure, it is a compound selected from formulas (X-IV-1), (X-IV-2), (X-IV-3), (X-XVIII-1), (X-XVIII-2), and (X-XVIII-3):

[0337] in

[0338] Y 1 Selected from O; Y 2 Selected from O;

[0339] U 1 Selected from CH and N;

[0340] U 8 Selected from CH and N;

[0341] U 9 Selected from CH and N;

[0342] U 2 —U 3 "Selected from the following groups:"

[0343] U 4 —U 5 "Selected from the following groups:"

[0344] U 6 —U 7 "Selected from the following groups:"

[0345] Each R a The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either identical or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0346] Or, when they exist, two R a Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 Cycloalkyl, C6 aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0347] Each R b The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either identical or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0348] Or, when they exist, two R b Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 Cycloalkyl, C6 aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0349] Each R c The following groups, which may be identical or different and independently selected from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0350] Or, when they exist, two R c Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 Cycloalkyl, C6 aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0351] Each R g The following groups, which may be identical or different and independently selected from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 Cycloalkyl-NH-,-C(O)C 1-6Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0352] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl groups, 3-6 membered heterocyclic groups;

[0353] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, 3-6 membered heterocyclic groups;

[0354] R h Selected from -COOH,

[0355] R i Selected from halogens, SF3, SF5, C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2;

[0356] Each m, n, p, v is the same or different, and is independently selected from 0, 1, or 2.

[0357] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0358] According to embodiments of this disclosure, in compounds of formulas (X-IV-1), (X-IV-2), (X-IV-3), (X-XVIII-1), (X-XVIII-2), and (X-XVIII-3), each R a The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -COOH.

[0359] According to embodiments of this disclosure, in compounds of formulas (X-IV-1), (X-IV-2), (X-IV-3), (X-XVIII-1), (X-XVIII-2), and (X-XVIII-3), each R bThe following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -COOH.

[0360] According to embodiments of this disclosure, in compounds of formulas (X-IV-1), (X-IV-2), (X-IV-3), (X-XVIII-1), (X-XVIII-2), and (X-XVIII-3), each R c The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -COOH;

[0361] Or, when they exist, two R c Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 4-6 Cycloalkyl, phenyl, furanyl, thiophene, pyrrolyl, pyrazolyl, triazolyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, dihydrofuranyl, dihydrothiophene, dihydropyrrolyl, dihydropyranyl.

[0362] According to embodiments of this disclosure, in compounds of formulas (X-IV-1), (X-IV-2), (X-IV-3), (X-XVIII-1), (X-XVIII-2), and (X-XVIII-3), each R gThe following groups, selected independently from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, aziridine, oxaziridine, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -COOH;

[0363] Or, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, oxetyl, thiohexacyclobutyl, aziridine, oxetyl, and aziridine;

[0364] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups with no substitution or optional substitution: cyclopentyl, cyclohexyl, oxetyl, thiohexyl, azirtobutyl, oxetyl, thiohexyl, azirtopentyl, oxetyl, thiohexyl, and azirtohexyl.

[0365] According to embodiments of this disclosure, in compounds of formulas (X-IV-1), (X-IV-2), (X-IV-3), (X-XVIII-1), (X-XVIII-2), and (X-XVIII-3), R h Selected from -COOH.

[0366] According to embodiments of this disclosure, in compounds of formulas (X-IV-1), (X-IV-2), (X-IV-3), (X-XVIII-1), (X-XVIII-2), and (X-XVIII-3), R iSelected from H, halogen, CN, OH, NH2, SF3, SF5, and unsubstituted or optionally substituted of the following groups: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, oxaziridine, thioaziridine, tetrahydrofuranyl, pyrrolylyl, piperidinyl, morpholinyl, 2,6-dimethylmorpholinyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2.

[0367] According to embodiments of this disclosure, it is a compound selected from formulas (X-II-1), (X-II-2), (X-II-3), (X-XVIV-1), (X-XVIV-2), and (X-XVIV-3):

[0368] in

[0369] Y 1 Selected from O; Y 2 Selected from O;

[0370] U 1 Selected from CH and N;

[0371] U 8 Selected from CH and N;

[0372] U 9 Selected from CH and N;

[0373] U 2 —U 3 "Selected from the following groups:"

[0374] U 4 —U 5 "Selected from the following groups:"

[0375] U 6 —U 7 "Selected from the following groups:"

[0376] Each R a The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either identical or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0377] Or, when they exist, two R a Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 Cycloalkyl, C6 aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0378] Each R b The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either identical or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0379] Or, when they exist, two R b Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 Cycloalkyl, C6 aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0380] Each R c The following groups, which may be identical or different and independently selected from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0381] Or, when they exist, two R c Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 Cycloalkyl, C6 aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0382] Each R g The following groups, which may be identical or different and independently selected from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 Cycloalkyl-NH-,-C(O)C 1-6Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0383] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl groups, 3-6 membered heterocyclic groups;

[0384] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, 3-6 membered heterocyclic groups;

[0385] R h Selected from -COOH,

[0386] R i Selected from halogens, SF3, SF5, C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2;

[0387] Each m, n, p, v is the same or different, and is independently selected from 0, 1, or 2.

[0388] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0389] According to embodiments of this disclosure, in compounds of formulas (X-II-1), (X-II-2), (X-II-3), (X-XVIV-1), (X-XVIV-2), and (X-XVIV-3), each R a The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -COOH.

[0390] According to embodiments of this disclosure, in compounds of formulas (X-II-1), (X-II-2), (X-II-3), (X-XVIV-1), (X-XVIV-2), and (X-XVIV-3), each R b The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -COOH.

[0391] According to embodiments of this disclosure, in compounds of formulas (X-II-1), (X-II-2), (X-II-3), (X-XVIV-1), (X-XVIV-2), and (X-XVIV-3), each R c The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -COOH;

[0392] Or, when they exist, two R c Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 4-6 Cycloalkyl, phenyl, furanyl, thiophene, pyrrolyl, pyrazolyl, triazolyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, dihydrofuranyl, dihydrothiophene, dihydropyrrolyl, dihydropyranyl.

[0393] According to embodiments of this disclosure, in compounds of formulas (X-II-1), (X-II-2), (X-II-3), (X-XVIV-1), (X-XVIV-2), and (X-XVIV-3), each R g The following groups, selected independently from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, aziridine, oxaziridine, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -COOH;

[0394] Or, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, oxetyl, thiohexacyclobutyl, aziridine, oxetyl, and aziridine;

[0395] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups with no substitution or optional substitution: cyclopentyl, cyclohexyl, oxetyl, thiohexyl, azirtobutyl, oxetyl, thiohexyl, azirtopentyl, oxetyl, thiohexyl, and azirtohexyl.

[0396] According to embodiments of this disclosure, in compounds of formulas (X-II-1), (X-II-2), (X-II-3), (X-XVIV-1), (X-XVIV-2), and (X-XVIV-3), R h Selected from -COOH.

[0397] According to embodiments of this disclosure, in compounds of formulas (X-II-1), (X-II-2), (X-II-3), (X-XVIV-1), (X-XVIV-2), and (X-XVIV-3), R i Selected from H, halogen, CN, OH, NH2, SF3, SF5, and unsubstituted or optionally substituted of the following groups: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, oxaziridine, thioaziridine, tetrahydrofuranyl, pyrrolylyl, piperidinyl, morpholinyl, 2,6-dimethylmorpholinyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2.

[0398] According to embodiments of this disclosure, it is a compound selected from formulas (X-III-1), (X-III-2), (X-III-3), (X-XVIVI-1), (X-XVIVI-2), and (X-XVIVI-3):

[0399] in

[0400] Y 1 Selected from O; Y 2 Selected from O;

[0401] U 1 Selected from CH and N;

[0402] U 8 Selected from CH and N;

[0403] U 9 Selected from CH and N;

[0404] U2 —U 3 "Selected from the following groups:"

[0405] U 4 —U 5 "Selected from the following groups:"

[0406] U 6 —U 7 "Selected from the following groups:"

[0407] Each R a The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either identical or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0408] Or, when they exist, two R aTogether with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 Cycloalkyl, C6 aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0409] Each R b The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either identical or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0410] Or, when they exist, two R b Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 Cycloalkyl, C6 aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0411] Each R cThe following groups, which may be identical or different and independently selected from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0412] Or, when they exist, two R c Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 Cycloalkyl, C6 aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic;

[0413] Each R g The following groups, which may be identical or different and independently selected from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 Cycloalkyl-NH-,-C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0414] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl groups, 3-6 membered heterocyclic groups;

[0415] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, 3-6 membered heterocyclic groups;

[0416] R h Selected from -COOH,

[0417] R i Selected from halogens, SF3, SF5, C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkyl-3-6-membered heterocyclic group, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 3-6 cycloalkyl-C 1-3 Alkyloxy, C 1-6 Alkyl-3-6-membered heterocyclic oxy group, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 cycloalkyl-NH-, C 3-6 cycloalkyl-C 1-3 Alkyl-NH-, C 1-6 Alkyl-3-6-membered heterocyclic groups -NH-, -C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)C 1-3 Alkyl-C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl)2;

[0418] Each m, n, p, v is the same or different, and is independently selected from 0, 1, or 2.

[0419] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0420] According to embodiments of this disclosure, in compounds of formulas (X-III-1), (X-III-2), (X-III-3), (X-XVIVI-1), (X-XVIVI-2), and (X-XVIVI-3), each R aThe following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -COOH.

[0421] According to embodiments of this disclosure, in compounds of formulas (X-III-1), (X-III-2), (X-III-3), (X-XVIVI-1), (X-XVIVI-2), and (X-XVIVI-3), each R b The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -COOH.

[0422] According to embodiments of this disclosure, in compounds of formulas (X-III-1), (X-III-2), (X-III-3), (X-XVIVI-1), (X-XVIVI-2), and (X-XVIVI-3), each R c The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -COOH;

[0423] Or, when they exist, two R cTogether with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 4-6 Cycloalkyl, phenyl, furanyl, thiophene, pyrrolyl, pyrazolyl, triazolyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, dihydrofuranyl, dihydrothiophene, dihydropyrrolyl, dihydropyranyl.

[0424] According to embodiments of this disclosure, in compounds of formulas (X-III-1), (X-III-2), (X-III-3), (X-XVIVI-1), (X-XVIVI-2), and (X-XVIVI-3), each R g The following groups, selected independently from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, aziridine, oxaziridine, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -COOH;

[0425] Or, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, oxetyl, thiohexacyclobutyl, aziridine, oxetyl, and aziridine;

[0426] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups with no substitution or optional substitution: cyclopentyl, cyclohexyl, oxetyl, thiohexyl, azirtobutyl, oxetyl, thiohexyl, azirtopentyl, oxetyl, thiohexyl, and azirtohexyl.

[0427] According to embodiments of this disclosure, in compounds of formulas (X-III-1), (X-III-2), (X-III-3), (X-XVIVI-1), (X-XVIVI-2), and (X-XVIVI-3), R h Selected from -COOH.

[0428] According to embodiments of this disclosure, in compounds of formulas (X-III-1), (X-III-2), (X-III-3), (X-XVIVI-1), (X-XVIVI-2), and (X-XVIVI-3), R iSelected from H, halogen, CN, OH, NH2, SF3, SF5, and unsubstituted or optionally substituted of the following groups: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, oxaziridine, thioaziridine, tetrahydrofuranyl, pyrrolylyl, piperidinyl, morpholinyl, 2,6-dimethylmorpholinyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2.

[0429] This disclosure also provides compounds, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts thereof represented by the formula (YI):

[0430] Among them, X 1 X 2 X 3 X 4 X 5 Y 1 Y 2 A, B, C, R a R b R c R f1 R f2 The definitions of m, n, and p are as described in any of the schemes disclosed herein;

[0431] Each R k1 Or R k2 They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups, C 3-20 Cycloalkyloxy, C 1-20 Alkyloxy, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, 3-20 membered heterocyclic oxy group;

[0432] Or, R k1 and R k2 Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C3-20 Cycloalkynyl, 3-20 membered heterocyclic groups.

[0433] According to embodiments of this disclosure, the compound has the following structure:

[0434] Among them, Y 1 Y 2 A, B, C, R a R b R c R f1 R f2 R g The definitions of m, n, p, v, t1, and t2 are as described in any of the embodiments disclosed herein;

[0435] Each R k1 Or R k2 They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups, C 3-20 Cycloalkyloxy, C 1-20 Alkyloxy, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, 3-20 membered heterocyclic oxy group;

[0436] Or, R k1 and R k2 Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups.

[0437] According to the implementation scheme of this disclosure (YI), each R k1 Or R k2 They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-12 Alkyl, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group, C 3-12 Cycloalkyloxy, C 1-12 Alkyloxy, C 3-12 Cycloalkyloxy, C 3-12Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, 3-12 membered heterocyclic oxy group;

[0438] Or, R k1 and R k2 Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group.

[0439] According to the implementation scheme of this disclosure (YI), each R k1 Or R k2 They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl, C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, 3-6 membered heterocyclic, C 3-6 Cycloalkyloxy, C 1-6 Alkyloxy, C 3-6 Cycloalkyloxy, C 3-6 Cycloalkenyloxy, C 3-6 Cycloalkynyloxy group, 3-6 membered heterocyclic oxy group;

[0440] Or, R k1 and R k2 Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, 3-6 membered heterocyclic group.

[0441] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0442] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), each R k1 Or R k2The same or different, independently selected from H, halogen, hydroxyl, cyano, and the following groups, unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl;

[0443] Or, R k1 and R k2 Together with the atoms they bond to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, and cyclopentyl.

[0444] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), Y 1 Selected from O; Y 2 Selected from O.

[0445] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), A is selected from the following optionally substituted groups:

[0446] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), B is selected from the following optionally substituted groups:

[0447] Of the above groups, the right half contains This indicates that an R is connected to the right end. b R connected to the right endb Selected from: -COOH, Preferably, the R connected at the right end b It is -COOH.

[0448] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), C is selected from optionally substituted groups such as:

[0449] Of the above groups, the right half contains This indicates that an R is connected to the right end. c R connected to the right end c Selected from the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxecyclobutyl, oxecyclopentyl, oxecyclohexyl, morpholinyl, -P(=O)(C 1-6 Alkyl)2、-C(=O)(C 1-6 alkyl).

[0450] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), each R a The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either identical or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-、-C(O)C 1-6 alkyl.

[0451] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), each R a The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3.

[0452] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), each R b The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either identical or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 Cycloalkyl-NH-,-C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -COOH.

[0453] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), each R b The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, tetrahydrofuranyl, pyrrolyl, tetrahydropyranyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -COOH.

[0454] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), each R c The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either identical or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6 Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 Cycloalkyl-NH-,-C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -COOH.

[0455] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), each R cThe following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, tetrahydrofuranyl, pyrrolyl, tetrahydropyranyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -COOH.

[0456] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), R f1 R f2 Identical or different, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl, cyclopropyl, cyclobutyl.

[0457] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), each R g The following groups, which may be identical or different and independently selected from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, and are unsubstituted or optionally substituted: C 1-6 Alkyl, hydroxyl C 1-6 Alkyl, Halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, hydroxy C 3-6 cycloalkyl, halogenated C 3-6Cycloalkyl, 3-6 membered heterocyclic alkyl, hydroxy 3-6 membered heterocyclic alkyl, halogenated 3-6 membered heterocyclic alkyl, C 3-6 cycloalkyl-C 1-3 Alkyl, hydroxyl C 3-6 cycloalkyl-C 1-3 Alkyl, Halogenated C 3-6 cycloalkyl-C 1-3 Alkyl, C 1-6 Alkoxy, hydroxy C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyloxy, hydroxyl C 3-6 Cycloalkyloxy, halogenated C 3-6 Cycloalkyloxy, C 1-6 Alkyl-NH-, (C 1-6 Alkyl)2N-, C 3-6 Cycloalkyl-NH-,-C(O)C 1-6 Alkyl, -C(O)C 3-6 Cycloalkyl, -C(O)NH2, -C(O)NH(C 1-6 Alkyl), -C(O)N(C 1-6 Alkyl group 2, -COOH;

[0458] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl groups, 3-6 membered heterocyclic groups;

[0459] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 Cycloalkyl groups, 3-6 membered heterocyclic groups.

[0460] According to embodiments of this disclosure, in compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), each R gThe following groups, selected independently from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, aziridine, oxaziridine, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -COOH;

[0461] Or, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, oxetyl, thiohexacyclobutyl, aziridine, oxetyl, and aziridine;

[0462] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups with no substitution or optional substitution: cyclopentyl, cyclohexyl, oxetyl, thiohexyl, azirtobutyl, oxetyl, thiohexyl, azirtopentyl, oxetyl, thiohexyl, and azirtohexyl.

[0463] According to embodiments of this disclosure, in the compounds of formulas (YI), (YI-1), (YI-2), (YI-3), (Y-II-1), (Y-II-2), (Y-II-3), (Y-III-1), (Y-III-2), (Y-III-3), (Y-IV-1), (Y-IV-2), (Y-IV-3), (YV-1), (YV-2), (YV-3), (Y-VI-1), (Y-VI-2), (Y-VI-3), each m, n, p, v, t1, t2 is the same or different, and is independently selected from 0, 1, or 2.

[0464] According to embodiments of this disclosure, the compound has the following structure:

[0465] Among them, Y 1 A, B, R a R b R c R f2 R g The definitions of m, n, p, and v are as above;

[0466] U 10 Selected from O, S, NR f3 ;

[0467] U 11 U 12 U 13 U 14 They are either the same or different, and are selected independently from CH and N;

[0468] R f3 Selected from H, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 heteroaryl, 3-20 heterocyclic.

[0469] According to the implementation scheme of this disclosure, R f3 Selected from H, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl, vinyl, ethynyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxacyclobutyl, oxacyclopentyl, oxacyclohexyl.

[0470] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0471] On the other hand, the second set of solutions provided in this disclosure consists of compounds or pharmaceutically acceptable salts thereof represented by formula (3-I):

[0472] in,

[0473] X 1 X 5 Same or different, selected independently from CR 1 C and N;

[0474] X 2 X 3 X 4 Same or different, selected independently from CR 1 R 2 NR 3 and N;

[0475] R 1 and R 2 They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups, C 3-20 Cycloalkyloxy, C 1-20 Alkyloxy, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, 3-20 membered heterocyclic oxy group;

[0476] R 3 Selected from H, unsubstituted or optionally substituted groups: C 1-20 Alkyl, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups;

[0477] Or, when present, R on the same atom 1 and R 2 Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups;

[0478] Or, when present, R on different atoms 1 R 2 R 3 The two atoms bonded to it together form the following unsubstituted or optionally substituted groups: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups;

[0479] Each The same or different, independently representing single or double bonds, are conditions that are related to... The bonded groups conform to the valence bond rule;

[0480] Y 1 Selected from O, S and NH;

[0481] A is selected from C 6-20 Aryl, C 3-20 Cycloalkyl, 3-20 membered heterocyclic, 3-20 membered heteroaryl, wherein, when present, the atom in A bonded to the NH on the left or the B on the right is C or N;

[0482] Each R aIdentical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(O)2R 7 -S(O)2OR 8 -OS(O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0483] B is selected from C. 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 6-20 Aryl, C 3-20 Cycloalkyl, 3-20 membered heterocyclic, 3-20 membered heteroaryl, wherein when present, the atom in B bonded to the left-hand group A is C or N;

[0484] Each R b Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(O)2R 7 -S(O)2OR 8 -OS(O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0485] Or, when they exist, two R a Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic;

[0486] Or, when they exist, two R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic;

[0487] Or, when it exists, R a R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic;

[0488] Y2 Selected from O, S and NH;

[0489] Z is selected from

[0490] C does not exist or is selected from C. 6-20 Aryl, C 3-20 Cycloalkyl, 3-20 membered heterocyclic, 3-20 membered heteroaryl;

[0491] D is selected from C 6-20 Aryl, C 3-20 Cycloalkyl, 3-20 membered heterocyclic, 3-20 membered heteroaryl;

[0492] Each R c Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(=O)R 4 -C(=O)OR 5 -OC(=O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(O)2OR 8 -OS(O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0493] Or, when they exist, two R c Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic;

[0494] R f1 R f2 R f3 Identical or different, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic;

[0495] Or, R f1 and R f3 It forms unsubstituted or optionally substituted 3-20 membered heterocyclic groups with the atoms it is connected to;

[0496] R 4 R 5 R 6 R 7 R 8 R 9 R 10 R 11 R 12 R 13 R 14 R 15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 Aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2;

[0497] m, n, and p may be the same or different, and are independently selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.

[0498] According to an embodiment of this disclosure (3-I), when the group (C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(O)2R 7 -S(O)2OR 8 -OS(O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 When described as "optionally substituted" or "substituted," it means that any of the groups can be replaced by one, two, or more groups selected from R. d The group is substituted.

[0499] According to the implementation scheme of this disclosure (3-I), each R d Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(=O)R d4 -C(=O)OR d5 -OC(=O)R d6 -S(=O)(=NH)R d7 -S(=O)2R d7 -S(O)2OR d8 -OS(O)2R d9 -B(OR) d10 (OR) d11 -P(=O)R d12 R d13 -P(O)(OR) d14 (OR) d15 );

[0500] Among them, R d4 R d5 R d6 R d7 R d8 R d9 R d10 R d11 R d12 R d13 R d14 R d15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 Aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2.

[0501] According to the implementation scheme of this disclosure (3-I), when each R d When replaced, it can be selected from one, two or more of R. e Substitution of groups;

[0502] Among them, each R e Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(=O)R e4 -C(=O)OR e5 -OC(=O)R e6 -S(=O)(=NH)R e7 -S(=O)2R e7 -S(O)2OR e8 -OS(O)2R e9 -B(OR) e10 (OR) e11 -P(=O)R e12 R e13 -P(O)(OR) e14 (OR) e15 );

[0503] Among them, R e4 R e5 R e6 R e7 R e8 R e9 R e10 R e11 R e12 R e13 R e14 R e15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 Aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2.

[0504] According to an embodiment of this disclosure (3-I), the halogen is selected from F, Cl, Br or I.

[0505] According to the implementation scheme of this disclosure (3-I), X 1 X 5 They are either the same or different, and are selected independently from CH and N.

[0506] According to the implementation scheme of this disclosure (3-I), X 2 X 3 X 4 Same or different, selected independently from CR 1 R 2 NR 3 CR 1 C and N;

[0507] R 1 and R 2 They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-12 Alkyl, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group, C 3-12 Cycloalkyloxy, C 1-12 Alkyloxy, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, 3-12 membered heterocyclic oxy group;

[0508] R 3 Selected from H, unsubstituted or optionally substituted groups: C 1-12 Alkyl, C 3-12 cycloalkyl, C3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic groups;

[0509] Or, when present, R on the same atom 1 and R 2 Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic groups;

[0510] Or, when present, R on different atoms 1 R 2 R 3 The two atoms bonded to it together form the following unsubstituted or optionally substituted groups: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group.

[0511] According to the implementation scheme of this disclosure (3-I), each The same or different, independently representing single or double bonds, are conditions that are related to... The bonded groups conform to the valence bond rule. Preferably, One or two of them One is a double bond, the others are single bonds. For example, Selected from 1, 2, 3 or 4 selected from R 1 R 2 and R 3 The substituents replace the following groups:

[0512] According to the implementation scheme of this disclosure (3-I), A is selected from C. 6-12 Aryl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic, 3-12 membered heteroaryl, such as phenyl (e.g. ), naphthyl, pyridyl (e.g.) ), pyrazinyl (e.g.) ), pyrimidine group (such as ), pyridazinyl (e.g.) ), cyclohexyl, piperidinyl, piperazinyl, quinolinyl, benzimidazolyl, benzothiophene, benzofuranyl, hexahydropyrimidinyl, hexahydropyridazinyl, 1,2-dihydropyridinyl (e.g. ), 1,4-dihydropyridyl, morpholinyl; or, the C 3-12Cycloalkyl, 3-12 membered heterocyclic, and 3-12 membered heteroaryl groups can be selected from bicyclic groups, such as fused rings, bridged rings, or spirocyclic groups, for example, spiro[3.3]heptyl (such as... ), spiro[3,4]octyl (e.g. ), spiro[3.5]nonyl (e.g. ), spiro[4.4]nonyl (e.g. ), spiro[4.5]decyl (e.g. ), spiro[5.5]undecyl (e.g. ).

[0513] According to the implementation scheme of this disclosure (3-I), each R a Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)(=NH)R 7 -S(O)2R 7 -S(O)2OR 8 -OS(O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0514] For example, each R aIdentical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azircyclobutyl, azircyclopentyl, azircyclohexyl, oxacyclobutyl, oxacyclopentyl, oxacyclohexyl, -P(=O)(C) 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl group, -S(=O)2NH2, -COOH.

[0515] According to the implementation scheme of this disclosure (3-I), B is selected from C. 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 6-12 Aryl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic, 3-12 membered heteroaryl, such as vinyl, ethynyl, propynyl, phenyl (e.g.) ), naphthyl, pyridyl (e.g.) ), pyrazinyl (e.g.) ), pyrimidine group (such as ), pyridazinyl (e.g.) ), quinolinyl, benzimidazolyl, benzothiophene, benzofuranyl, cyclohexyl, piperidinyl, piperazinyl, hexahydropyrimidinyl, hexahydropyridazinyl, 1,2-dihydropyridinyl (e.g. ), 1,4-dihydropyridyl, morpholinyl; or, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic, and 3-12 membered heteroaryl groups can be selected from bicyclic groups, such as fused rings, bridged rings, or spirocyclic groups, for example, spiro[3.3]heptyl (e.g. ), spiro[3,4]octyl (e.g. ), spiro[3.5]nonyl (e.g. ), spiro[4.4]nonyl (e.g. ), spiro[4.5]decyl (e.g. ), spiro[5.5]undecyl (e.g. ).

[0516] According to the implementation scheme of this disclosure (3-I), each R bIdentical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(O)2R 7 -S(O)2OR 8 -OS(O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0517] For example, each R b Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azircyclobutyl, azircyclopentyl, azircyclohexyl, oxacyclobutyl, oxacyclopentyl, oxacyclohexyl, -P(=O)(C) 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl), S(=O)(=NH)C 1-6 Alkyl group, -S(=O)2NH2, -COOH.

[0518] Alternatively, according to an embodiment of this disclosure (3-I), when present, the two Rs a Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic groups, such as azircyclopentenyl, etc.

[0519] Alternatively, according to an embodiment of this disclosure (3-I), when present, the two Rs b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic groups, such as azircyclopentenyl, etc.

[0520] Alternatively, according to an embodiment of this disclosure (3-I), when present, R a R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 heteroaryl, 3-12 heterocyclic.

[0521] Alternatively, according to an embodiment of this disclosure (3-I), when present, R a R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, C 6-10 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic.

[0522] According to the implementation scheme of this disclosure (3-I), the combination schemes of A and B are as follows:

[0523] According to the implementation scheme of this disclosure (3-I), Y 2 Selected from O, S, and NH.

[0524] According to the implementation scheme of this disclosure (3-I), C does not exist or is selected from C. 3-12 Cycloalkyl, 3-12 membered heterocyclic groups, such as cyclopropyl (e.g.) ), cyclobutyl (e.g.) ), cyclohexyl (such as ), bicyclo[1.1.1]pentyl (e.g. ), piperidinyl (e.g.) ), piperazinyl, hexahydropyrimidinyl, hexahydropyridazinyl, morpholinyl; or, the C 3-12 Cycloalkyl and 3-12 membered heterocyclic groups can be selected from bicyclic groups, such as fused rings, bridged rings, or spirocyclic groups, for example, spiro[3.3]heptyl (e.g. ), spiro[3,4]octyl (e.g. ), spiro[3.5]nonyl (e.g. ), spiro[4.4]nonyl (e.g. ), spiro[4.5]decyl (e.g. ), spiro[5.5]undecyl (e.g. ).

[0525] According to the implementation scheme of this disclosure (3-I), D is selected from C. 6-12 Aryl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic, 3-12 membered heteroaryl, such as phenyl (e.g. ), naphthyl, pyridyl (e.g.) ), pyrazinyl (e.g.) ), pyrimidine group (such as ), pyridazinyl (e.g.) ), quinolinyl, benzimidazolyl, benzothiophene, benzofuranyl, cyclopropyl (e.g. ), cyclobutyl (e.g.) ), cyclopentyl, cyclohexyl (e.g.) ), bicyclo[1.1.1]pentyl (e.g. ), piperidinyl (e.g.) ), piperazinyl, hexahydropyrimidinyl, hexahydropyridazinyl, 1,2-dihydropyridinyl (e.g. ), 1,4-dihydropyridyl, morpholinyl; or, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic, and 3-12 membered heteroaryl groups can be selected from bicyclic groups, such as fused rings, bridged rings, or spirocyclic groups, for example, spiro[3.3]heptyl (e.g. ), spiro[3,4]octyl (e.g. ), spiro[3.5]nonyl (e.g. ), spiro[4.4]nonyl (e.g. ), spiro[4.5]decyl (e.g. ), spiro[5.5]undecyl (e.g. ).

[0526] According to the embodiment of this disclosure (3-I), C does not exist; and D is selected from cyclopropyl (e.g., ), cyclobutyl (e.g.) ), cyclopentyl, cyclohexyl (e.g.) ), bicyclo[1.1.1]pentyl (e.g. ), piperidinyl (e.g.) ), piperazinyl, hexahydropyrimidinyl, hexahydropyridazinyl.

[0527] According to the embodiment of this disclosure (3-I), C does not exist; and D is selected from cyclobutyl (e.g. ), cyclopentyl, cyclohexyl (e.g.) ), bicyclo[1.1.1]pentyl (e.g. ).

[0528] According to the embodiment of this disclosure (3-I), C is selected from cyclopropyl (e.g., ), cyclobutyl (e.g.) ), cyclohexyl (such as ), bicyclo[1.1.1]pentyl (e.g. ), piperidinyl (e.g.) ), piperazinyl, hexahydropyrimidinyl, hexahydropyridazinyl, morpholinyl; and D is selected from C 6-12 Aryl, 3-12-membered heteroaryl, such as phenyl (e.g.) ), naphthyl, pyridyl (e.g.) ), pyrazinyl (e.g.) ), pyrimidine group (such as ), pyridazinyl (e.g.) ), quinolinyl, benzimidazolyl, benzothiophene, benzofuranyl.

[0529] According to the embodiment of this disclosure (3-I), C is selected from cyclopropyl (e.g., ), cyclobutyl (e.g.) ), cyclohexyl (such as ), bicyclo[1.1.1]pentyl (e.g. ); and D is selected from C. 6-12 Aryl, 3-12-membered heteroaryl, such as phenyl (e.g.) ), naphthyl, pyridyl (e.g.) ), pyrazinyl (e.g.) ), pyrimidine group (such as ), pyridazinyl (e.g.) ).

[0530] According to the embodiment of this disclosure (3-I), the combination of C and D is selected from the following groups:

[0531] Each R c Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(=O)R 4 -C(=O)OR 5 -OC(=O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(O)2OR 8 -OS(O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0532] For example, each R c Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), C 1-6 Alkoxy (methoxy, ethoxy, propoxy, isopropoxy), C 1-6Alkylamino (methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino), C 3-6 Cycloalkyl (cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl), C 3-6 Heterocyclic alkyl groups (azacyclobutyl, azacyclopentyl, azacyclohexyl, oxacyclobutyl, oxacyclopentyl, oxacyclohexyl, morpholinyl), C 6-10 Aryl (e.g., phenyl), -P (=O)(C 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH;

[0533] Or, when they exist, two R c Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 heteroaryl, 3-12 heterocyclic.

[0534] According to the implementation scheme of this disclosure (3-I), R f1 R f2 R f3 Identical or different, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl, vinyl, ethynyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azircyclobutyl, azircyclopentyl, azircyclohexyl, oxacyclobutyl, oxacyclopentyl, oxacyclohexyl;

[0535] Or, R f1 and R f3 The atoms bonded to it form unsubstituted or optionally substituted 3-10 membered heterocyclic groups, such as azirmonobutylene (e.g., ...). ), 8-azaspiro[4.5]decyl (e.g. The optional substitution is optional substitution by a group selected from the following groups: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), C 6-10Aryl (e.g., phenyl groups optionally substituted with methyl, trifluoromethyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, cyclopropyl, cyclobutyl, monoheteropropyl, or azirrobutyl), 5-6 membered heteroaryl (e.g., furanyl, thiophene, pyridinyl, or pyrimidinyl groups optionally substituted with methyl, trifluoromethyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, cyclopropyl, cyclobutyl, monoheteropropyl, or azirrobutyl).

[0536] According to the implementation scheme of this disclosure (3-I), R f1 and R f3 The atoms connected to each other form

[0537] According to the implementation scheme of this disclosure (3-I), R 4 R 5 R 6 R 7 R 8 R 9 R 10 R 11 R 12 R 13 R 14 R 15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 Aryloxy group, 5-12-membered heteroaryloxy group, 3-12-membered heterocyclic oxy group, NH2.

[0538] According to the implementation scheme of this disclosure (3-I), R 4 R 5 R 6 R 7 R 8 R 9 R 10 R 11 R 12 R 13R 14 R 15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, C 6-6 Aryl, 5-6 membered heteroaryl, 3-6 membered heterocyclic, C 1-6 Alkyloxy, C 2-6 alkenyloxy group, C 2-6 alkynyloxy group, C 3-6 Cycloalkyloxy, C 3-6 Cycloalkenyloxy, C 3-6 Cycloalkynyloxy group, C 6-6 Aryloxy group, 5-6 membered heteroaryloxy group, 3-6 membered heterocyclic oxy group, NH2.

[0539] According to the implementation scheme of this disclosure (3-I), R 4 R 5 R 6 R 7 R 8 R 9 R 10 R 11 R 12 R 13 R 14 R 15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl, Halogenated C 2-6 Alkyl, C 1-6 Alkyloxy group, halogenated C 1-6 Alkyloxy group.

[0540] According to the implementation scheme of this disclosure (3-I), R 4 R 5 R 6 R 7 R 8 R 9 R 10 R 11 R 12 R 13 R 14 R 15 They are the same or different, and are selected independently from H or C. 1-6 Alkyl (e.g., methyl).

[0541] According to the implementation of this disclosure (3-I), m, n, and p are the same or different, and are independently selected from 0, 1, 2, 3, 4, 5, or 6.

[0542] According to an embodiment of this disclosure (3-I), the “substituted” or “optionally substituted” group has the definition in the context of this specification.

[0543] According to an embodiment of this disclosure (3-I), the compound has the following structure:

[0544] Among them, Y 1 Y 2 X 1 X 2 X 3 X 4 X 5 A, B, R a R b R f2 , m, n, Z have the definitions described above.

[0545] According to an embodiment of this disclosure (3-I), the compound has the following structure:

[0546] Among them, Y 1 Y 2 A, B, C, D, R a R b R c R f1 R f2 R f3 The definitions of m, n, and p are as described in scheme (3-I);

[0547] Each R g They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups, C 3-20 Cycloalkyloxy, C 1-20 Alkyloxy, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, 3-20 membered heterocyclic oxy group;

[0548] Or, when present, two R atoms on the same atomg Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups;

[0549] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups;

[0550] v can be the same or different, and can be selected independently from 0, 1, 2, 3, 4 or 5.

[0551] According to the implementation scheme of this disclosure (3-I), each R g They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-12 Alkyl, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group, C 3-12 Cycloalkyloxy, C 1-12 Alkyloxy, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, 3-12 membered heterocyclic oxy group;

[0552] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic groups;

[0553] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group.

[0554] According to the implementation scheme of this disclosure (3-I), each R g They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-6Alkyl, C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, 3-6 membered heterocyclic, C 3-6 Cycloalkyloxy, C 1-6 Alkyloxy, C 3-6 Cycloalkyloxy, C 3-6 Cycloalkenyloxy, C 3-6 Cycloalkynyloxy group, 3-6 membered heterocyclic oxy group;

[0555] Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalynyl, 3-6 membered heterocyclic groups;

[0556] Or, when present, two R atoms on the same atom g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0557] Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalynyl, 3-6 membered heterocyclic groups;

[0558] Or, when present, two R atoms on different atoms g Together with the atoms they are bonded to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine.

[0559] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0560] According to an embodiment of this disclosure (3-I), the compound has the following structure:

[0561] Among them, Y 1 Y 2 C, R a R b Rc R g R f1 R f3 The definitions of m, n, p, and v are as described in scheme (3-I);

[0562] R h Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(O)2R 7 -S(O)2OR 8 -OS(O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0563] R i Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(=O)R 4 -C(=O)OR 5 -OC(=O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(O)2OR 8 -OS(O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0564] U 1 U 8 U 9 They are either the same or different, and are selected independently from CH and N;

[0565] U 2 —U 3 "Selected from the following groups:"

[0566] U 4 —U 5 "Selected from the following groups:"

[0567] U 6 —U 7 "Selected from the following groups:"

[0568] Each t1 is either the same or different, and is independently selected from 0, 1, 2, 3, 4 or 5.

[0569] According to the implementation scheme of this disclosure (3-I), R h Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(O)2R 7 -S(O)2OR 8 -OS(O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0570] For example, R h Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azircyclobutyl, azircyclopentyl, azircyclohexyl, oxacyclobutyl, oxacyclopentyl, oxacyclohexyl, -P(=O)(C) 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl), S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)₂NH₂, -COOH. Alternatively, R... h Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and C. 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azircyclobutyl, azircyclopentyl, azircyclohexyl, oxacyclobutyl, oxacyclopentyl, oxacyclohexyl, -P(=O)(C) 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl), S(=O)(=NH)C 1-6 Alkyl, -S(=O)2NH2, -COOH, unsubstituted or optionally substituted with the following groups: pyridinyl, pyrazinyl, pyridazinyl, furanyl, thiopheneyl, pyrimidinyl, isoxazolyl, isothiazolyl, oxazolyl, thiazolyl, pyrazolyl, furazonyl, pyrroleyl, triazolyl, tetrazolyl, 1,2,4-thiadiazolyl, pyridazinyl; the substituent is selected from halogen, hydroxyl, mercapto, cyano, nitro, oxo(=O), thio(=S), SF3, SF5, C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl); preferably, the substituents are selected from hydroxyl, amino, or C. 1-3 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl).

[0571] According to the implementation scheme of this disclosure (3-I), R i Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(=O)R 4 -C(=O)OR 5 -OC(=O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(O)2OR8 -OS(O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 );

[0572] For example, R i Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), C 1-6 Alkoxy (methoxy, ethoxy, propoxy, isopropoxy), C 1-6 Alkylamino (methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino), C 3-6 Cycloalkyl (cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl), C 3-6 Heterocyclic alkyl groups (azacyclobutyl, azacyclopentyl, azacyclohexyl, oxacyclobutyl, oxacyclopentyl, oxacyclohexyl, morpholinyl), C 6-10 Aryl (e.g., phenyl), -P (=O)(C 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6Alkyl, -S(=O)2NH2, -COOH; the optional substituents are selected from the following groups: F, Cl, Br, I, OH, SH, CN, NO2, N3, SF5, SF3, NH2, oxo(=O), -NHCH3, -N(CH3)2, -C(O)CH3, COOH, -CO2CH3, -CONH2, -CONHCH3, -CON(CH3)2, -CH2OH, =NH, =NCH3, -P(=O)(OH)2, -P(=O)(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, -S(=O)2CH3, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl alkyl, pentyl, isopentyl, neopentyl, trifluoromethyl, difluoromethyl, cyclopropyl, cyclobutyl, cyclopentyl, methoxy, ethoxy, propoxy, methylthio, ethylthio, propylthio, cyclopropoxy, cyclopropylthio, cyclopropylamino, aziridinyl, aziridine, oxacyclobutyl, thiohexacyclobutyl, tetrahydrofuranyl, pyrrolyl, tetrahydropyranyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperazinyl, homopiperidinyl, aziridineheptyl Oxyheptanyl, phenyl, naphthyl, furanyl, thiophene, oxazolyl, thiazolyl, imidazole, pyrazolyl, isothiazolyl, isoxazolyl, triazolyl, benzofuranyl, benzothiophene, benzoimidazolyl, benzothiazolyl, benzoisothiazolyl, benzooxazolyl, benzoisooxazolyl, benzooxazinyl, benzotriazolyl, quinolinyl, oxazolopyridyl, isoxazolopyridyl, pyrrolopyridyl, furanolopyridyl, thiopheneolopyridyl;

[0573] Preferably, the optional substituents are selected from the following groups: F, Cl, Br, I, OH, SF5, SF3, NH2, oxo(=O), -NHCH3, -N(CH3)2, -C(O)CH3, COOH, -CO2CH3, -CONH2, -CONHCH3, -CON(CH3)2, -CH2OH, =NH, =NCH3, -P(=O)(OH)2, -P(=O)(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, -S(=O)2CH3, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, trifluoromethyl, difluoromethyl, cyclopropyl, cyclobutyl, cyclopentyl.

[0574] According to the implementation of this disclosure (3-I), each t1 is the same or different, and is independently selected from 0, 1, 2 or 3.

[0575] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0576] According to the implementation scheme of this disclosure (3-I), R h Selected from -H, -COOH, -CH2CF3, -CHF2, -S(=O)(=N)CH3, -P(=O)(CH3)2, -S(=O)2NH2, -CF3, methyl, amino,

[0577] According to the implementation scheme of this disclosure (3-I), R h Selected from -COOH.

[0578] According to the implementation scheme of this disclosure (3-I), R a Selected from halogens (e.g., fluorine, chlorine, or bromine), oxo (=O), thio (=S), SF3, SF5, C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), C 1-6 Alkoxy (methoxy, ethoxy, propoxy, isopropoxy), NH2, -NHC 1-6 Alkyl, -N(C) 1-6 Alkyl)2, -SC 1-6 Alkyl; for example, R a Selected from fluorine, methyl, cyano, methoxy, isopropyl, and methylthio.

[0579] According to the implementation scheme of this disclosure (3-I), R b Selected from halogens (e.g., fluorine, chlorine, or bromine), oxo (=O), thio (=S), SF3, SF5, C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), C 1-6 Alkoxy (methoxy, ethoxy, propoxy, isopropoxy), NH2, -NHC 1-6 Alkyl, -N(C) 1-6 Alkyl)2, -SC 1-6 Alkyl; for example, R b Selected from fluorine, methyl, cyano, methoxy, isopropyl, and methylthio.

[0580] According to the implementation scheme of this disclosure (3-I), U 1 U 8 U 9They are either the same or different, and are selected independently from CH and N;

[0581] U 2 —U 3 "Selected from the following groups:"

[0582] U 4 —U 5 "Selected from the following groups:"

[0583] U 6 —U 7 "Selected from the following groups:"

[0584] Each t1 is either the same or different, and is independently selected from 0, 1 or 2.

[0585] The “substituted” or “optionally substituted” groups have the definition in the context of this specification.

[0586] According to the implementation scheme of this disclosure (3-I), Selected from

[0587] According to the implementation scheme of this disclosure (3-I), R i Selected from halogens, SF3, SF5, C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), C 1-6 Alkoxy (methoxy, ethoxy, propoxy, isopropoxy), halogenated C 1-6 Alkoxy (-OCF3), C 1-6 Alkylamino (methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino), 2-propenyl, C 3-6 Cycloalkyl (cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl), C 3-6 Heterocyclic alkyl groups (azacyclobutyl, azacyclopentyl, azacyclohexyl, oxacyclobutyl, oxacyclopentyl, oxacyclohexyl, morpholinyl), C 6-10 Aryl (e.g., phenyl), -P (=O)(C 1-6 Alkyl)2 (e.g., -P(=O)(methyl)2), -C(=O)(C)2 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl, -S(=O)2NH2, -COOH hydroxyl, mercapto, cyano, nitro, oxo (=O), thio (=S)

[0588] According to embodiments of formula (I) or (3-I), the compound has the structures shown in (3-XI-1) to (3-XI-65) as follows:

[0589] Among them, Y 1 Y 2 , R f1 R f2 R i and R h The definition is as described above;

[0590] R n The definition of R is the same as above. c ;

[0591] R l R j R k R m Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)(=NH)R 7 -S(O)2R 7 -S(O)2OR 8 -OS(O)2R 9-B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 ).

[0592] According to the embodiments of this disclosure, in the structures shown in (3-XI-1) to (3-XI-65), R l R j R k R m They may be the same or different, and are independently selected from H, halogens (such as F), CN, OH, SH, NH2, SF3, SF5, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, thiocyclobutyl, tetrahydrofuranyl, pyrrolidine, piperidinyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, di... Ethylamino, dipropylamino, diisopropylamino, cyclopropyl NH-, -C(O)CH3, -S(=O)2CH3, -C(O)NH2, -C(O)NHCH3, -C(O)N(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2NHCF3, -S(=O)2N(CH3)2, -N=S(=O)(CH3)2, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, -S(=O)(=N-CN)CH3, -P(=O)(CH3)2, -COOH.

[0593] According to the embodiments of this disclosure, in the structures shown in (3-XI-1) to (3-XI-65), Y 1 Selected from O, S, and NH.

[0594] According to the embodiments of this disclosure, in the structures shown in (3-XI-1) to (3-XI-65), Y 2 Selected from O, S, and NH.

[0595] According to the embodiments of this disclosure, in the structures shown in (3-XI-1) to (3-XI-65), Y 1 and Y 2 Selected from O; or, Y 1 and Y 2 Selected from S; or, Y 1 Selected from O, Y 2 Selected from S; or, Y1 Selected from S, Y 2 Selected from O.

[0596] According to the embodiments of this disclosure, in the structures shown in (3-XI-1) to (3-XI-65), Selected from

[0597] According to the embodiments of this disclosure, in the structures shown in (3-XI-1) to (3-XI-65), R f1 R f2 They may be the same or different, and are independently selected from H, methyl, ethyl, and isopropyl.

[0598] According to the embodiments of this disclosure, in the structures shown in (3-XI-1) to (3-XI-65), R i Selected from halogens, SF3, SF5, C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), C 1-6 Alkoxy (methoxy, ethoxy, propoxy, isopropoxy), halogenated C 1-6 Alkoxy (-OCF3), C 1-6 Alkylamino (methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino), 2-propenyl, C 3-6 Cycloalkyl (cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl), C 3-6 Heterocyclic alkyl groups (azacyclobutyl, azacyclopentyl, azacyclohexyl, oxacyclobutyl, oxacyclopentyl, oxacyclohexyl, morpholinyl), C 6-10 Aryl (e.g., phenyl), -P (=O)(C 1-6 Alkyl)2 (e.g., -P(=O)(methyl)2), -C(=O)(C)2 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl, -S(=O)2NH2, -COOH hydroxyl, mercapto, cyano, nitro, oxo (=O), thio (=S)

[0599] According to the embodiments of this disclosure, in the structures shown in (3-XI-1) to (3-XI-65), R h Selected from -H, -COOH, -CH2CF3, -CHF2, -S(=O)(=N)CH3, -P(=O)(CH3)2, -S(=O)2NH2, -CF3, methyl, amino,

[0600] According to the embodiments of this disclosure, in the structures shown in (3-XI-1) to (3-XI-65), R n Selected from H, F, methyl, ethyl, isopropyl, CN, CF3, SF3, SF5, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, amino, methylamino, dimethylamino, ethylamino, and propylamino.

[0601] According to the embodiments of this disclosure, in the structures shown in (3-XI-1) to (3-XI-65), R l R j R k R m Same, H;

[0602] Or, R l R j R k For H, R m Selected from F, methyl, ethyl, isopropyl, CN, CF3, SF3, SF5, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, amino, methylamino, dimethylamino, ethylamino, propylamino;

[0603] Or, R m R j R k For H, R l Selected from F, methyl, ethyl, isopropyl, CN, CF3, SF3, SF5, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, amino, methylamino, dimethylamino, ethylamino, propylamino;

[0604] Or, R m R l R k For H, R j Selected from F, methyl, ethyl, isopropyl, CN, CF3, SF3, SF5, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, amino, methylamino, dimethylamino, ethylamino, propylamino;

[0605] Or, R m R l R j For H, R k Selected from F, methyl, ethyl, isopropyl, CF3, CN, SF3, SF5, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, amino, methylamino, dimethylamino, ethylamino, and propylamino.

[0606] According to embodiments of this disclosure, the compound is selected from the compounds shown in Table 1, their stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts thereof:

[0607] Table 1

[0608] According to an embodiment of this disclosure (3-I), the compound is selected from the compounds in Table 2 or their stereoisomers or racemates:

[0609] Table 2

[0610] This disclosure also provides a method for preparing the compound of formula (I) or a pharmaceutically acceptable salt thereof, comprising: reacting compounds II-1, II-2 and II-3 to obtain the compound of formula (I) or a pharmaceutically acceptable salt thereof:

[0611] Among them, X 1 X 2 X 3 X 4 X 5 Y 1 Y 2 A, B, C, R a R b R c m, n, and p have the definitions described above;

[0612] L 1 L 2 They are selected independently from leaving groups, such as halogens.

[0613] According to embodiments of this disclosure, compound II-1 may react with compound II-2 first, and then with compound II-3; or, compound II-1 may react with compound II-3 first, and then with compound II-2.

[0614] This disclosure also provides a method for preparing the compound of formula (3-I) or a pharmaceutically acceptable salt thereof, comprising: reacting compounds 3-II-1, 3-II-2 and 3-II-3 to obtain the compound of formula (3-I) or a pharmaceutically acceptable salt thereof:

[0615] Among them, X 1 X 2 X 3 X 4 X 5 Y 1 Y 2 A, B, Z, R a R b R f2 m and n have the definitions described above;

[0616] L 1 L 2 They are selected independently from leaving groups, such as halogens.

[0617] According to an embodiment of this disclosure (3-1), compound 3-II-1 may react with compound 3-II-2 first, and then with compound 3-II-3; or, compound 3-II-1 may react with compound 3-II-3 first, and then with compound 3-II-2.

[0618] According to embodiments of this disclosure, the preparation method further includes reacting the compound represented by formula (I) or (3-I) under salt-forming conditions to obtain a pharmaceutically acceptable salt thereof.

[0619] According to embodiments of this disclosure, the preparation method can be carried out in an organic solvent, preferably in the presence of a base.

[0620] According to embodiments of this disclosure, the preparation method further includes the step of protecting the undesirable functional groups with a protecting group, and removing the protecting group after the reaction is complete. The protecting group may be a hydroxyl protecting group, an amino protecting group, or other groups known in the art.

[0621] This disclosure also provides a pharmaceutical composition comprising at least one of the above-described compounds, their stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts.

[0622] According to embodiments of this disclosure, the pharmaceutical composition further comprises pharmaceutically acceptable excipients, such as carriers or excipients.

[0623] According to embodiments of this disclosure, the pharmaceutical composition is used to treat diseases or conditions associated with GIP or GIPR.

[0624] This disclosure also provides the use of at least one of the above-mentioned compounds, their stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts thereof in the preparation of a medicament for treating diseases or conditions associated with GIP or GIPR.

[0625] This disclosure also provides a method for preventing and / or treating diseases or conditions associated with GIP or GIPR, comprising administering at least one of the above-described compounds, their stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts thereof to a patient in need.

[0626] This disclosure also provides the use of at least one of the above-mentioned compounds, their stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts thereof in the prevention and / or treatment of diseases or conditions associated with GIP or GIPR.

[0627] According to the technical solution of this disclosure, the diseases or conditions related to GIP or GIPR are selected from at least one of the following:

[0628] Diabetes, such as type 1 diabetes (T1D), type 2 diabetes (T2DM), including prediabetes, idiopathic T1D (Type 1b), latent autoimmune diabetes in adults (LADA), early-onset T2DM (EOD), adolescent atypical diabetes (YOAD), adolescent adult-onset diabetes (MODY), malnutrition-related diabetes, gestational diabetes, hyperglycemia, insulin resistance, hepatic insulin resistance, impaired glucose tolerance, diabetic neuropathy, diabetic nephropathy, kidney diseases [e.g., acute kidney disease, tubular dysfunction, pro-inflammatory changes in proximal tubules, or chronic kidney disease (CKD)], diabetic retinopathy, adipocyte dysfunction, visceral fat deposition, sleep apnea [e.g., obstructive sleep apnea (OSA)], obesity (including hypothalamic obesity and... Monogenic obesity and related comorbidities (e.g., osteoarthritis and urinary incontinence), eating disorders (including bulimia syndrome, bulimia nervosa, and syndromic obesity such as Prad-Willi syndrome and Budd-Bead syndrome), weight gain, such as weight gain due to the use of other medications (e.g., due to the use of steroids and / or antipsychotics, due to the treatment of depression, or due to the use of medications that affect cognitive function), excessive sugar intake, dyslipidemia [including hyperlipidemia, hypertriglyceridemia, elevated total cholesterol, high LDL (low-density lipoprotein) cholesterol and low HDL (high-density lipoprotein) cholesterol], hyperinsulinemia, non-alcoholic fatty liver disease [NAFLD, including fatty liver disease, non-alcoholic ... Fatty degeneration, non-alcoholic steatohepatitis (NASH) and related diseases, fibrosis, cirrhosis and hepatocellular carcinoma, cardiovascular diseases, atherosclerosis (including coronary artery disease), peripheral vascular disease, hypertension, endothelial dysfunction, impaired vascular compliance, heart failure [e.g. congestive heart failure, heart failure with preserved ejection fraction (HFpEF), heart failure with reduced ejection fraction (HFrEF)], myocardial infarction (e.g. necrosis and apoptosis), stroke, hemorrhagic stroke, ischemic stroke, traumatic brain injury, pulmonary hypertension, restenosis after angioplasty, intermittent claudication, postprandial lipemia, metabolic acidosis, ketosis, arthritis, osteoporosis, osteoarthritis, Parkinson's disease, etc. Kimberly's disease, left ventricular hypertrophy, peripheral artery disease, macular degeneration, cataracts, glomerulosclerosis, chronic renal failure, metabolic syndrome, syndrome X, premenstrual syndrome, angina pectoris, thrombosis, atherosclerosis, transient ischemic attack, restenosis, impaired glucose metabolism, impaired fasting glucose status, hyperuricemia, gout, erectile dysfunction, skin and connective tissue diseases, psoriasis, foot ulcers, ulcerative colitis, hyperapolipoprotein B, Alzheimer's disease, schizophrenia, cognitive impairment, inflammatory bowel disease, short bowel syndrome, Crohn's disease, colitis, irritable bowel syndrome, polycystic ovary syndrome (PCOS), and addictions (e.g., alcohol, nicotine, and / or drug addiction).

[0629] Terminology Definitions and Explanations

[0630] Unless otherwise stated, the definitions of groups and terms recorded in this application specification and claims, including definitions as examples, exemplary definitions, preferred definitions, definitions recorded in tables, and definitions of specific compounds in the examples, can be arbitrarily combined and combined with each other. Such combinations and combinations of group definitions and compound structures should be understood as being within the scope of this application specification and / or claims.

[0631] Unless otherwise stated, the numerical ranges described in this specification and claims are equivalent to describing at least each specific integer value therein. For example, the numerical range "1-20" is equivalent to describing each integer value in the numerical range "1-10", namely 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and each integer value in the numerical range "11-20", namely 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20. Furthermore, when certain numerical ranges are described as "numbers", it should be understood that they describe the two endpoints of the range, each integer within the range, and each decimal within the range. For example, "numbers from 0 to 10" should be understood to describe not only each integer of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10, but also at least the sum of each of these integers with 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, and 0.9.

[0632] It should be understood that in the description of 1, 2 or more, "more" should refer to an integer greater than 2, such as an integer greater than or equal to 3, such as 3, 4, 5, 6, 7, 8, 9 or 10.

[0633] The term "halogen" refers to fluorine, chlorine, bromine, and iodine.

[0634] Term "C" 1-20 "Alkyl" should be understood as referring to a straight-chain or branched saturated monovalent hydrocarbon group having 1 to 20 carbon atoms. For example, "C 1-12 "Alkyl" refers to straight-chain and branched alkyl groups having 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12 carbon atoms. 1-10 "Alkyl" refers to straight-chain and branched alkyl groups having 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 carbon atoms. 1-6"Alkyl" means a straight-chain or branched alkyl group having 1, 2, 3, 4, 5, or 6 carbon atoms. The alkyl group is, for example, methyl, ethyl, propyl, butyl, pentyl, hexyl, isopropyl, isobutyl, sec-butyl, tert-butyl, isopentyl, 2-methylbutyl, 1-methylbutyl, 1-ethylpropyl, 1,2-dimethylpropyl, neopentyl, 1,1-dimethylpropyl, 4-methylpentyl, 3-methylpentyl, 2-methylpentyl, 1-methylpentyl, 2-ethylbutyl, 1-ethylbutyl, 3,3-dimethylbutyl, 2,2-dimethylbutyl, 1,1-dimethylbutyl, 2,3-dimethylbutyl, 1,3-dimethylbutyl, or 1,2-dimethylbutyl, or their isomers.

[0635] Term "C" 2-20 "Alkenyl" should be understood to preferably represent a straight-chain or branched monovalent hydrocarbon group containing one, two or more double bonds and having 2 to 20 carbon atoms, preferably "C". 2-12 "Alkenyl". "C" 2-12 "Alkenyl" should be understood to preferably represent a straight-chain or branched monovalent hydrocarbon group containing one, two or more double bonds and having 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms, for example, having 2, 3, 4, 5 or 6 carbon atoms (i.e., C...). 2-6 alkenyl), having 2 or 3 carbon atoms (i.e., C24, C34, C4 ... 2-3Alkenyl). It should be understood that when the alkenyl group contains more than one double bond, the double bonds may be separable or conjugated. The alkenyl group is, for example, vinyl, allyl, (E)-2-methylvinyl, (Z)-2-methylvinyl, (E)-but-2-enyl, (Z)-but-2-enyl, (E)-but-1-enyl, (Z)-but-1-enyl, pent-4-enyl, (E)-pent-3-enyl, (Z)-pent-3-enyl, (E)-pent-2-enyl, (Z)-pent-2-enyl, (E)- Pentyl-1-enyl, (Z)-pentyl-1-enyl, hex-5-enyl, (E)-hex-4-enyl, (Z)-hex-4-enyl, (E)-hex-3-enyl, (Z)-hex-3-enyl, (E)-hex-2-enyl, (Z)-hex-2-enyl, (E)-hex-1-enyl, (Z)-hex-1-enyl, isopropenyl, 2-methylprop-2-enyl, 1-methylprop-2-enyl 2-Methylprop-1-enyl, (E)-1-methylprop-1-enyl, (Z)-1-methylprop-1-enyl, 3-methylbut-3-enyl, 2-methylbut-3-enyl, 1-methylbut-3-enyl, 3-methylbut-2-enyl, (E)-2-methylbut-2-enyl, (Z)-2-methylbut-2-enyl, (E)-1-methylbut-2-enyl, (Z)-1-methyl But-2-enyl, (E)-3-methylbut-1-enyl, (Z)-3-methylbut-1-enyl, (E)-2-methylbut-1-enyl, (Z)-2-methylbut-1-enyl, (E)-1-methylbut-1-enyl, (Z)-1-methylbut-1-enyl, 1,1-dimethylprop-2-enyl, 1-ethylprop-1-enyl, 1-propylvinyl, 1-isopropylvinyl.

[0636] Term "C" 2-20 "Alkyne group" should be understood as representing a straight-chain or branched monovalent hydrocarbon group containing one, two, or more triple bonds and having 2 to 20 carbon atoms, preferably "C". 2-12 "Alkyne group". The term "C" 2-12 "Alkyne" should be understood to preferably represent a straight-chain or branched monovalent hydrocarbon group containing one, two or more triple bonds and having 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms, for example, having 2, 3, 4, 5 or 6 carbon atoms (i.e., "C"). 2-6 The alkynyl group ("C") has 2 or 3 carbon atoms ("C") 2-3The alkynyl group is, for example, ethynyl, prop-1-alkynyl, prop-2-alkynyl, but-1-alkynyl, but-2-alkynyl, but-3-alkynyl, pent-1-alkynyl, pent-2-alkynyl, pent-3-alkynyl, pent-4-alkynyl, hex-1-alkynyl, hex-2-alkynyl, hex-3-alkynyl, hex-4-alkynyl, hex-5-alkynyl, 1-methylprop-2-alkynyl, 2-methylbut-3-alkynyl, 1-methylbut-3-alkynyl, 1-methylbut-2-alkynyl, 3-methylbut-1-alkynyl, 1-ethylprop-2-alkynyl, 3-methylpent-4-alkynyl, 2-methylpent-4-alkynyl, 1-methylpent-4-alkynyl -Alynyl, 2-methylpentan-3-ynyl, 1-methylpentan-3-ynyl, 4-methylpentan-2-ynyl, 1-methylpentan-2-ynyl, 4-methylpentan-1-ynyl, 3-methylpentan-1-ynyl, 2-ethylbutan-3-ynyl, 1-ethylbutan-3-ynyl, 1-ethylbutan-2-ynyl, 1-propylpropan-2-ynyl, 1-isopropylpropan-2-ynyl, 2,2-dimethylbutan-3-ynyl, 1,1-dimethylbutan-3-ynyl, 1,1-dimethylbutan-2-ynyl, or 3,3-dimethylbutan-1-ynyl. In particular, the ynyl group is ethynyl, propan-1-ynyl, or propan-2-ynyl.

[0637] Term "C" 3-20 "Cycloalkyl" should be understood to refer to monovalent monocyclic, bicyclic (e.g., fused, bridged, spirocyclic), or tricyclic alkanes that are saturated or unsaturated (e.g., partially unsaturated), having 3 to 20 carbon atoms, preferably "C". 3-12 cycloalkyl. The term "C" 3-12 "Cycloalkyl" should be understood to refer to a saturated monovalent monocyclic, bicyclic (e.g., bridged, spirocyclic) hydrocarbon ring or tricyclic alkane having 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12 carbon atoms. The C... 3-10 Cycloalkyl groups can be monocyclic hydrocarbon groups, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, or cyclodecyl; or bicyclic hydrocarbon groups, such as borneolyl, indolyl, hexahydroindolyl, tetrahydronaphthyl, decahydronaphthyl, bicyclo[2.1.1]hexyl, bicyclo[2.2.1]heptyl, bicyclo[2.2.1]heptenyl, 6,6-dimethylbicyclo[3.1.1]heptyl, 2,6,6-trimethylbicyclo[3.1.1]heptyl, bicyclo[2.2.2]octyl; or tricyclic hydrocarbon groups, such as adamantyl; or spiro[3.3]heptyl (e.g. ), spiro[3,4]octyl (e.g. ), spiro[3.5]nonyl (e.g. ), spiro[4.4]nonyl (e.g. ), spiro[4.5]decyl (e.g. ), spiro[5.5]undecyl (e.g. ).

[0638] Those skilled in the art should understand that the term "C" 3-20 "Cycloalkyl" does not possess aromaticity. Furthermore, when the above "C" 3-20 When the cycloalkyl group is unsaturated, it can have more than one carbon-carbon double bond and / or more than one carbon-carbon triple bond. Specifically, when the "C" is unsaturated... 3-20 When a cycloalkyl group has a carbon-carbon double bond, it can also be called a "C60" cycloalkyl group. 3-20 "Cycloalkenyl"; when "C 3-20 When a cycloalkyl group has a carbon-carbon triple bond, it can also be called a "C60" cycloalkyl group. 3-20 Cycloynyl group.

[0639] The term "3-20 membered heterocyclic group" refers to a saturated or unsaturated non-aromatic ring or ring system, for example, a 4-, 5-, 6-, or 7-membered monocyclic ring, a 7-, 8-, 9-, 10-, 11-, or 12-membered bicyclic ring (such as a fused ring, bridged ring, or spirocyclic ring), or a 10-, 11-, 12-, 13-, 14-, or 15-membered tricyclic ring system, and contains at least one, for example, 1, 2, 3, 4, 5, or more heteroatoms selected from O, S, and N, wherein N and S may optionally be oxidized to various oxidation states to form nitrides, -S(=O)-, or -S(=O)2- states. Preferably, the heterocyclic group may be selected from "3-12 membered heterocyclic groups". The term "3-12 membered heterocyclic group" means a saturated or unsaturated non-aromatic ring or ring system containing at least one heteroatom selected from O, S, and N. The heterocyclic group can be connected to the rest of the molecule via any one of the carbon atoms or a nitrogen atom (if present). The heterocyclic group can include fused or bridged rings and spirocyclic rings. Specifically, the heterocyclic group can include, but is not limited to: 4-membered rings, such as azirrobutyl or oxobutyl; 5-membered rings, such as tetrahydrofuranyl, dioxacyclopentenyl, pyrrolyl, imidazoalkyl, pyrazolealkyl, or pyrrololinyl; or 6-membered rings, such as tetrahydropyranyl, piperidinyl, morpholinyl, dithiaalkyl, thiomorpholinyl, piperazineyl, or trithiaalkyl; or 7-membered rings, such as diazacycloheptyl. Optionally, the heterocyclic group can be benzofused. The heterocyclic group can be bicyclic, such as, but not limited to, a 5,5-membered ring, like a hexahydrocyclopentano[c]pyrrolo-2(1H)-yl ring, or a 5,6-membered bicyclic ring, such as a hexahydropyrrolo[1,2-a]pyrazinolo-2(1H)-yl ring. The heterocyclic group can be partially unsaturated, meaning it can contain one, two, or more double bonds, such as, but not limited to, dihydrofuranyl, dihydropyranyl, 2,5-dihydro-1H-pyrroloyl, 4H-[1,3,4]thiadiazinyl, 4,5-dihydrooxazolyl, or 4H-[1,4]thiazinyl, or it can be benzofused, such as, but not limited to, dihydroisoquinolinyl. When the 3-20-membered heterocyclic group is linked to other groups to form the compounds of this disclosure, the carbon atom on the 3-20-membered heterocyclic group can be linked to other groups, or the heterocyclic atom on the 3-20-membered heterocyclic group ring can be linked to other groups. For example, when the 3-20 membered heterocyclic group is selected from piperazine, the nitrogen atom on the piperazine group can be attached to other groups. Or when the 3-20 membered heterocyclic group is selected from piperidinyl, the nitrogen atom on the piperidinyl ring and the carbon atom at its para position can be attached to other groups. For example, the substituted 4-10 membered heterocyclic group can be selected from: 1-methylpyrrolyl, 1-ethylpyrrolyl, 1-cyclopropylpyrrolyl, 1-cyclopropylmethylpyrrolyl, 5-methyl-4,5-dihydropyridazine-3(2H)-keto, 1-methylazacyclobutane, 1-methylpiperidinyl, 2,7-diazaspiro[3,5]nonyl, 2,6-diazaspiro[3,4]octyl.

[0640] Term "C" 6-20 "Aryl" should preferably be understood to represent a monocyclic, bicyclic (such as fused ring, bridged ring, spiro ring), or tricyclic hydrocarbon ring having 6 to 20 carbon atoms and possessing monovalent aromaticity or partial aromaticity. It can be a monoaromatic ring or a polyaromatic ring fused together, preferably "C". 6-14 "Aromatic". The term "C" 6-14 "Aryl" should be understood to preferably represent a monovalent aromatic or partially aromatic monocyclic, bicyclic, or tricyclic hydrocarbon ring ("C") having 6, 7, 8, 9, 10, 11, 12, 13, or 14 carbon atoms. 6-14 Aryl), particularly a ring with 6 carbon atoms (“C6 aryl”), such as phenyl; or biphenyl, or a ring with 9 carbon atoms (“C9 aryl”), such as indenyl or indenyl, or a ring with 10 carbon atoms (“C9 aryl”). 10 Aryl groups, such as tetrahydronaphthyl, dihydronaphthyl, or naphthyl, or rings with 13 carbon atoms (“C”). 13 Aryl groups, such as fluorene groups, or rings with 14 carbon atoms (“C”). 14 Aryl), for example, anthracene. When the C 6-20 When the aryl group is substituted, it can be monosubstituted or polysubstituted. Furthermore, there are no restrictions on the substitution site; for example, it can be ortho, para, or meta substituted.

[0641] The term "5-20-membered heteroaryl" should be understood to include monocyclic, bicyclic (e.g., fused, bridged, spirocyclic), or tricyclic aromatic ring systems having 5 to 20 ring atoms and containing 1 to 5 heteroatoms independently selected from N, O, and S, for example, "5-14-membered heteroaryl". The term "5-14-membered heteroaryl" should also be understood to include monocyclic, bicyclic, or tricyclic aromatic ring systems having 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14 ring atoms, particularly 5, 6, 9, or 10 carbon atoms, and containing 1 to 5, preferably 1 to 3, heteroatoms independently selected from N, O, and S, and in each case, may be benzo[a]fused. "Hyperaryl" also refers to a group in which the heteroaryl ring is fused with one, two, or more aryl, alicyclic, or heterocyclic rings, wherein the root or point of the connection is on the heteroaryl ring. Non-limiting examples of the term "heteroaryl" include, for example, pyridyl, pyrazinyl, pyridazinyl, furanyl, thiopheneyl, pyrimidinyl, isoxazolyl, isothiazolyl, oxazolyl, thiazolyl, pyrazolyl, furazonyl, pyrroleyl, triazolyl, tetrazolyl, 1,2,4-Thiadiazolyl, pyridazinyl; and 1-, 2-, 3-, 5-, 6-, 7- or 8-indazinyl, 1-, 3-, 4-, 5-, 6- or 7-isoindolyl, 2-, 3-, 4-, 5-, 6- or 7-indolyl, 2-, 3-, 4-, 5-, 6- or 7-indazolyl, 2-, 4-, 5-, 6-, 7- or 8-purinel, 1-, 2-, 3-, 4-, 6-, 7-, 8- or 9-quinazinyl, 2-, 3-, 4-, 5-, 6-, 7- or 8-quinolinyl, 1-, 3-, 4-, 5-, 6-, 7- or 8-isoquinolinyl, 1-, 4-, 5-, 6-, 7- or 8-phthalazinyl, 2-, 3-, 4-, 5- or 6- Naphthidyl, 2-, 3-, 5-, 6-, 7- or 8-quinazolinyl, 3-, 4-, 5-, 6-, 7- or 8-pyrolinyl, 2-, 4-, 6- or 7-pteridyl, 1-, 2-, 3-, 4-, 5-, 6-, 7- or 8-4aH carbazole, 1-, 2-, 3-, 4-, 5-, 6-, 7- or 8-carbazole carbazole, 1 -, 3-, 4-, 5-, 6-, 7-, 8- or 9-carboline, 1-, 2-, 3-, 4-, 6-, 7-, 8-, 9- or 10-phenanthridyl, 1-, 2-, 3-, 4-, 5-, 6-, 7-, 8- or 9-acridyl, 1-, 2-, 4-, 5-, 6-, 7-, 8- or 9-pyridyl, 2-, 3-, 4-, 5- 6, 8, 9, or 10-phenanthroline, 1, 2, 3, 4, 6, 7, 8, or 9-phenazinyl, 1, 2, 3, 4, 6, 7, 8, 9, or 10-phenthiazinyl, 1, 2, 3, 4, 6, 7, 8, 9, or 10-phenazinyl, 2, 3, 4, 5, 6, or 1-, 3-, 4-, 5-, 6-, 7-, 8-, 9- or 10-benzoisoquinolinyl, 2-, 3-, 4- or thieno[2,3-b]furanyl, 2-, 3-, 5-, 6-, 7-, 8-, 9-, 10- or 11-7H-pyrazino[2,3-c]carbazoleyl, 2-, 3-, 5-, 6- or 7-2H-furano[3 ,2-b]-pyranyl, 2-,3-,4-,5-,7- or 8-5H-pyrido[2,3-d]-o-azinyl, 1-,3- or 5-1H-pyrazolo[4,3-d]-thiazolyl, 2-,4- or 5-1H-imidazo[4,5-d]thiazolyl, 3-,5- or 8-pyrazolo[2,3-d]pyridazinyl, 2-,3- 5- or 6-imidazo[2,1-b]thiazolyl, 1-, 3-, 6-, 7-, 8- or 9-furanzo[3,4-c]cenolinyl, 1-, 2-, 3-, 4-, 5-, 6-, 8-, 9-, 10- or 11-4H-pyrido[2,3-c]carbazolel, 2-, 3-, 6- or 7-imidazo[1,2-b][1,2,4] Triazine, 7-benzo[b]thiophene, 2-, 4-, 5-, 6- or 7-benzozozolyl, 2-, 4-, 5-, 6- or 7-benzimidazolyl, 2-, 4-, 4-, 5-, 6- or 7-benzothiazolyl, 1-, 2-, 4-, 5-, 6-, 7-, 8- or 9-benzoxapinyl, 2-, 4-, 5-, 6-, 7- or 8-benzoazine, 1-, 2-, 3-, 5-, 6-, 7-, 8-, 9-, 10- or 11-1H-pyrrolo[1,2-b][2]benzozapinyl. Typical fused heteroaryl groups include, but are not limited to, 2-, 3-, 4-, 5-, 6-, 7- or 8-quinolinyl, 1-, 3-, 4-, 5-, 6-, 7- or 8-isoquinolinyl, 2-, 3-, 4-, 5-, 6- or 7-indolyl, 2-, 3-, 4-, 5-, 6- or 7-benzo[b]thiophene, 2-, 4-, 5-, 6- or 7-benzozozolyl, 2-, 4-, 5-, 6- or 7-benzimidazolyl, and 2-, 4-, 5-, 6- or 7-benzothiazolyl, benzimidazolyl, benzothiaphene, and benzofuranyl. When the 5-20-membered heteroaryl groups are linked to other groups to form the compounds disclosed herein, the carbon atom on the 5-20-membered heteroaryl ring may be linked to other groups, or the heteroatom on the 5-20-membered heteroaryl ring may be linked to other groups. When the 5-20 membered heteroaryl groups are substituted, they can be monosubstituted or polysubstituted. Furthermore, there are no restrictions on the substitution sites; for example, hydrogen atoms bonded to carbon atoms on the heteroaryl ring can be substituted, or hydrogen atoms bonded to heteroatoms on the heteroaryl ring can be substituted.

[0642] The term "spirocycle" refers to a ring system in which two rings share a single ring atom.

[0643] The term "fused ring" refers to a ring system in which two rings share two cyclic atoms.

[0644] The term "bridged ring" refers to a ring system in which two rings share three or more cyclic atoms.

[0645] Unless otherwise stated, heterocyclic, heteroaryl, or heteroaryl groups include all possible isomers, such as their positional isomers. Thus, for some illustrative, non-limiting examples, forms may include those in which one, two, or more of the following positions (if present) are substituted or bonded to other groups, including pyridin-2-yl, pyridin-2-yl, pyridin-3-yl, pyridin-3-yl, pyridin-4-yl, and pyridin-4-yl; thiophene or thiophene groups include thiophene-2-yl, thiophene-2-yl, thiophene-3-yl, and thiophene-3-yl; pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, and pyrazol-5-yl.

[0646] The term "oxo" refers to the substitution of a non-oxygen atom with a hydrogen atom or a lone pair of electrons by an oxygen atom, for example, After being oxidized, it becomes After being oxidized, it becomes

[0647] Unless otherwise stated, the definitions of terms in this document also apply to groups containing the term, such as C. 1-20 The definition of alkyl also applies to C 1-20 Alkyloxy, C 3-20 cycloalkyl-C 1-20 Alkyl-, Halogenated C 1-20 Alkyl groups, etc.

[0648] Unless otherwise stated, the term "halogenated alkyl" means that 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more H atoms on an alkyl group are replaced by halogens, such as monochloromethyl, dichloromethyl, trichloromethyl, trichloroethyl, trifluorochloro, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, etc.

[0649] Unless otherwise stated, the terms "alkyl", "alkenyl", "alkynyl", "cycloalkyl", "heterocyclic", "aryl", and "heteroaryl" above may be substituted independently in each case.

[0650] Unless otherwise stated, the term "optionally substituted" means that the group may be unsubstituted or substituted by one or more (e.g., 0, 1, 2, 3, 4, or 5 or more, or any range thereof) of the substituents listed for the group, wherein said substituents may be the same or different. In one embodiment, the optionally substituted group has 1 substituent. In another embodiment, the optionally substituted group has 2 substituents. In another embodiment, the optionally substituted group has 3 substituents. In another embodiment, the optionally substituted group has 4 substituents. In another embodiment, the optionally substituted group has 5 substituents. The optionally substituted group may be selected from the following groups: halogen; OH; NH2; CN; NO2; oxo group; C 1-12 Alkyl; C 2-12 alkenyl; C 2-12 alkynyl group; C 3-20 Cycloalkyl; 3-20 membered heterocyclic group; C 6-20 Aryl; 5-20 heteroaryl; C 2-12 alkenyl-C 1-12 Alkylene-; C 2-12 alkynyl-C 1-12 Alkylene-; C 6-20 Aryl-C 1-12alkylene-; 5-20-membered heteroaryl-C 1-12 Alkylene-;-OR′;-C(O)R′;-CO2R′;-OC(O)R′;-S(=O)R′;-S(=O)2R′;-NR″R″’;-CONR″R″′;-OC(O)NR″R″’;-NR″C(O)R′;-S(=O )NR″R″′; -S(=O)2NR″R″′; -NR″S(=O)R′; -NR″S(=O)2R′; -NR′C(O)NR″R″′; -NR′S(=O)NR″R″′; -NR′S(=O)2NR″R″′; -(CH2) 1-6 -R′;-(CH2) 1-6 -OR′;-(CH2) 1-6 -NR″R″′;-(CH2) 1-6 -SR′;-(CH2) 1-6 -SiR′R″R″′;-(CH2) 1-6 -OC(O)R′;-(CH2) 1-6 -C(O)R′;-(CH2) 1-6 -CO2R′; or -(CH2) 1-6 CONR″R″′; Each R′, R″, and R″′ independently refers to the following group: hydrogen; C 1-12 Alkyl; C 2-12 alkenyl; C 2-12 alkynyl group; C 3-20 Cycloalkyl; 3-20 membered heterocyclic group; C 6-20 Aryl; 5-20 heteroaryl; C 2-12 alkenyl-C 1-12 Alkylene-; C 2-12 alkynyl-C 1-12 Alkylene-; C 6-20 Aryl-C 1-12 alkylene-; 5-20-membered heteroaryl-C 1-12 Alkylene-; C 1-12 Alkyl acyl; C 2-12 alkenyl acyl; C 2-12 Entyl acyl group; C 3-20 Cycloalkyl acyl; 3-20 membered heterocyclic acyl; C 6-20 Aryl acyl; 5-20 membered heteroaryl acyl; C 1-12 alkylsulfonyl; C 2-12 alkenylsulfonyl; C 2-12 alkynylsulfonyl; C 3-20 Cycloalkylsulfonyl; 3-20 membered heterocyclic sulfonyl; C 6-20 arylsulfonyl; 5-20 membered heteroarylsulfonyl; C 1-12 alkylsulfinyl; C 2-12alkenylsulfinyl; C 2-12 alkynyl sulfinyl; C 3-20 Cycloalkyl sulfinyl; 3-20 membered heterocyclic sulfinyl; C 6-20 Arylsulfinyl group; 5-20 membered heteroarylsulfinyl group; when R” and R”′ are attached to the same nitrogen atom, it can combine with the nitrogen atom to form a 3-, 4-, 5-, 6-, or 7-membered ring, wherein the ring atom is optionally substituted with N, O, or S and the ring is optionally substituted with halogen, OH, CN, or C. 1-12 Alkyl, C 1-12 Alkoxy or oxo groups may be used for substitution. Optional substituents may also be selected from groups such as SF5 and SF3.

[0651] In some embodiments, specific examples of "optionally substituted" substituents are selected from the following groups: F, Cl, Br, I, OH, SH, CN, NO2, N3, SF5, SF3, NH2, oxo(=O), and the following optional substituents: -NHCH3, -N(CH3)2, -C(O)CH3, COOH, -CO2CH3, -CONH2, -CONHCH3, -CON(CH3)2, -CH2OH, =NH, =NCH3, -P(=O)(OH)2, -P(=O)(CH3)2, -S(=O)2NH2, -S(=O)2NHCH3, -S(=O)2N(CH3)2, -S(=O)2CH3, -S(=O)(=NH)CH3, -S(=O)(=NCH3)CH3, methyl, ethyl, propyl, isopropyl, butyl, isobutyl alkyl, tert-butyl, pentyl, isopentyl, neopentyl, trifluoromethyl, difluoromethyl, cyclopropyl, cyclobutyl, cyclopentyl, methoxy, ethoxy, propoxy, methylthio, ethylthio, propylthio, cyclopropoxy, cyclopropylthio, cyclopropylamino, aziridinyl, azacyclic butyl, oxacyclic butyl, thiocyclic butyl, tetrahydrofuranyl, pyrrolylyl, tetrahydropyranyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperazinyl, homopiperidinyl, azacyclic Heptyl, oxacycloheptyl, phenyl, naphthyl, furanyl, thiophene, oxazolyl, thiazolyl, imidazole, pyrazolyl, isothiazolyl, isoxazolyl, triazolyl, benzofuranyl, benzothiophene, benzoimidazolyl, benzothiazolyl, benzoisothiazolyl, benzooxazolyl, benzoisooxazolyl, benzooxazinyl, benzotriazolyl, quinolinyl, oxazolopyridyl, isoxazolopyridyl, pyrrolopyridyl, furanolopyridyl, thiophenopyridyl.

[0652] In the context of this disclosure, the "-", "--", "---" or "---" on the substituent base are used interchangeably. All of these are intended to label the substituents for the chemical bonds that are linked.

[0653] Those skilled in the art will understand that the compounds of this disclosure can exist in the form of various pharmaceutically acceptable salts. If these compounds have a basic center, they can form acid addition salts; if these compounds have an acidic center, they can form base addition salts; if these compounds contain both an acidic center (e.g., a carboxyl group) and a basic center (e.g., an amino group), they can also form inner salts.

[0654] The compounds disclosed herein may exist as solvates (such as hydrates), wherein the compounds of this disclosure contain a polar solvent, particularly, for example, water, methanol, or ethanol, as a structural element of the lattice of the compound. The amount of the polar solvent, particularly water, may be stoichiometric or non-stoichiometric. Unless otherwise stated, the compounds of this disclosure should be understood to encompass their solvates.

[0655] As used herein, the term "pharmaceutically acceptable" means a substance (such as a carrier or diluent) that does not affect the biological activity or properties of the compounds disclosed herein and is relatively non-toxic, i.e., that the substance can be administered to an individual without causing an adverse biological response or interacting adversely with any component contained in the composition.

[0656] Those skilled in the art will understand that the compounds of this disclosure can exist in the form of various pharmaceutically acceptable salts. If these compounds have a basic center, they can form acid addition salts; if these compounds have an acidic center, they can form base addition salts; if these compounds contain both an acidic center (e.g., a carboxyl group) and a basic center (e.g., an amino group), they can also form inner salts.

[0657] Unless otherwise stated, the compounds disclosed herein should be understood to encompass their tautomers. The term "tautomer" refers to a functional group isomer resulting from the rapid movement of an atom between two positions in a molecule. The compounds of this disclosure can exhibit tautomerism. Tautomers can exist in two or more interconvertible forms. Proton-transfer tautomers arise from the migration of covalently bonded hydrogen atoms between two atoms. Tautomers generally exist in equilibrium form, and attempts to isolate a single tautomer usually yield a mixture whose physicochemical properties are consistent with those of the mixture of compounds. The equilibrium position depends on the intramolecular chemical characteristics. For example, in many aliphatic aldehydes and ketones such as acetaldehyde, the keto form is dominant; while in phenols, the enol form is dominant. This disclosure includes all tautomer forms of the compounds.

[0658] Based on their molecular structure, the compounds disclosed herein can be chiral, and therefore may exist in various enantiomeric forms. Thus, these compounds can exist in racemic or optically active forms. The compounds disclosed herein cover isomers of each chiral carbon in the R or S configuration, or mixtures thereof, or racemates. The compounds or intermediates of this disclosure can be isolated as enantiomeric compounds by chemical or physical methods known to those skilled in the art, or used in this form for synthesis. In the case of racemic amines, diastereomers are obtained from the mixture by reaction with an optically active resolving agent. Examples of suitable resolving agents are optically active acids, such as tartaric acid in both R and S forms, diacetyltartaric acid, dibenzoyltartaric acid, mandelic acid, malic acid, lactic acid, suitable N-protected amino acids (e.g., N-benzoylproline or N-benzenesulfonylproline), or various optically active camphorsulfonic acids. Chromatographic enantiomer separation can also be advantageously performed using optically active resolving agents (e.g., dinitrobenzoylphenylglycine immobilized on silica gel, cellulose triacetate, or other carbohydrate derivatives, or chiral derivatized isobutylene ester polymers). Suitable eluents for this purpose are aqueous or alcoholic solvent mixtures, such as hexane / isopropanol / acetonitrile. The corresponding stable isomers can be separated according to known methods, such as extraction, filtration, or column chromatography.

[0659] Unless otherwise stated, the compounds disclosed herein should be understood to encompass their isotopic labels. "Isotope" refers to all isotopes of atoms appearing in the compounds of this disclosure. Isotopes include those atoms having the same atomic number but different mass numbers. Examples of isotopes suitable for inclusion in the compounds of this disclosure are hydrogen, carbon, nitrogen, oxygen, phosphorus, fluorine, and chlorine, respectively, for example, but not limited to, [examples of isotopes]. 2 H, 3 H, 13 C 14 C 15 N、 18 O、 31 P, 32 P, 35 S, 18 F and 36 C1. The isotopically labeled compounds of this disclosure can generally be prepared by conventional techniques known to those skilled in the art or by methods similar to those described in the appended examples, using appropriate isotopically labeled reagents instead of non-isotopically labeled preparations. Such compounds have a variety of potential uses, for example, as standards and reagents in the determination of biological activity. In the case of stable isotopes, such compounds have the potential to advantageously alter biological, pharmacological, or pharmacokinetic properties.

[0660] The term "prodrug" refers to a compound of this disclosure that can be converted into a biologically active form under physiological conditions or by solvation. The prodrugs of this disclosure are prepared by modifying a functional group in the compound; this modification can be performed conventionally or removed in vivo to yield the parent compound. Prodrugs comprise compounds formed by attaching a hydroxyl or amino group to any group in the compound of this disclosure. When a prodrug of this disclosure is administered to a mammalian individual, the prodrug is cleaved to form a free hydroxyl group and a free amino group.

[0661] The term "patient" refers to any animal, including mammals, preferably mice, rats, other rodents, rabbits, dogs, cats, pigs, cattle, sheep, horses, or primates, with humans being the most preferred.

[0662] The term “therapeutic effective amount” refers to the amount of an active compound or drug that researchers, veterinarians, physicians, or other clinicians are searching for in tissues, systems, animals, individuals, or humans to elicit a biological or medical response. It includes one or more of the following: (1) prevention of disease: e.g., prevention of disease, disorder, or condition in individuals susceptible to disease, disorder, or symptom but not yet experiencing or exhibiting the pathology or symptoms of the disease; (2) suppression of disease: e.g., suppression of disease, disorder, or symptom in individuals experiencing or exhibiting the pathology or symptoms of the disease, disorder, or symptom (i.e., prevention of further development of the pathology and / or symptoms); (3) relief of disease: e.g., relief of disease, disorder, or symptom in individuals experiencing or exhibiting the pathology or symptoms of the disease, disorder, or symptom (i.e., reversal of the pathology and / or symptoms). Beneficial effects

[0663] Compared to existing GIPR antagonist compounds, the compounds disclosed herein or their pharmaceutically acceptable salts exhibit significant advantages in several aspects, such as: (1) better GIPR antagonistic activity, achieving more potent receptor blocking at the cellular level; (2) superior pharmacokinetic properties, such as higher oral bioavailability and a longer elimination half-life, thus supporting once-daily oral dosing regimens; (3) higher safety, such as lower binding capacity to hERG potassium channels, suggesting a lower risk of potential cardiotoxicity; and (4) more significant synergistic therapeutic effects when used in combination with GLP-1 receptor agonists, specifically including inducing more significant weight loss in animal models, or achieving similar or even better hypoglycemic and weight control effects with lower doses of GLP-1 agonists, thereby potentially reducing GLP-1 agonist-related adverse reactions. Detailed Implementation

[0664] The technical solutions of this disclosure will be further described in detail below with reference to specific embodiments. It should be understood that the following embodiments are merely illustrative and explanatory of this disclosure and should not be construed as limiting the scope of protection of this disclosure. All technologies implemented based on the above content of this disclosure are covered within the scope of protection intended by the claims of this application.

[0665] Unless otherwise stated, the instruments and reagents used in the following examples are commercially available products or can be prepared by methods known in the art.

[0666] Example 1

[0667] Proline derivative compound 1-1: (R)-N 1 -(4-Isopropylphenyl)-N 2 -(4-(1-oxoisoindolin-5-yl)phenyl)pyrrolidine-1,2-dicarboxamide

[0668] Synthesis route:

[0669] Step 1: Preparation of ((4-isopropylphenyl)carbamoyl)-D-proline (1-1-A): At room temperature, compound SM1 (2.14 g, 1 eq) was dissolved in tetrahydrofuran (20 mL). After stirring and cooling to 0 °C, N-methylmorpholine (2.05 mL, 1.4 eq) and D-proline (SM2, 2.5 g, 1.6 eq) were added sequentially. The reaction mixture was then slowly heated to room temperature and stirred for 2 h. After the reaction was complete, a saturated sodium bicarbonate aqueous solution was added to the reaction system to adjust the pH to 7-8 to quench the reaction. The mixture was extracted with ethyl acetate, and the organic phase was separated. The aqueous phase was adjusted to pH 2 with dilute hydrochloric acid and stirred continuously for 20 minutes. The mixture was filtered under reduced pressure, the filter cake was washed with water, and the filter cake was dried at low temperature to obtain compound 1-1-A (3.1 g). The crude product was used directly in the next reaction without further purification.

[0670] Step-2: (R)-N 1 -(4-Isopropylphenyl)-N 2Preparation of 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaboran-2-yl)phenyl)pyrrolidine-1,2-dicarboxamide (1-1-B): Compound 1-1-A (1.5 g, 1 eq) and pinacol 4-aminophenylboronic acid (SM3, 1.2 g, 1.1 eq) were dissolved in 15 mL of dichloromethane at room temperature. After stirring and cooling to 0 °C, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI, 1.4 g, 1.4 eq) was added. The mixture was slowly heated to room temperature with stirring and reacted for 16 hours. The reaction was characterized by LCMS. After quenching with water, the mixture was extracted three times with dichloromethane. The combined organic phases were washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and evaporated to dryness. The resulting product was purified by normal-phase column chromatography to obtain intermediate 1-1-B (1.2 g).

[0671] Step-3: (R)-N 1 -(4-Isopropylphenyl)-N 2 Preparation of 1,2-dicarboxamide (4-(1-oxoisoindoline-5-yl)phenyl)pyrrolidine-1,2-dicarboxamide): Compound 1-1-B (120 mg, 1 eq), potassium carbonate (104 mg, 3 eq), 1,1′-bis(diphenylphosphino)ferrocene palladium(II) chloride (Pd(dppf)Cl2, 18 mg, 0.1 eq), and 5-bromo-2,3-dihydroisoindoline-1-one (SM4, 53 mg, 2 eq) were sequentially added to a dioxane / water mixture (v / v = 6 / 1, 7 mL). Under nitrogen protection, the mixture was heated to 100 °C and stirred for 12 h until the reaction was complete. The reaction solution was diluted with ethyl acetate, and the organic phase was washed sequentially with water and saturated sodium chloride aqueous solution. The ethyl acetate phase was dried over anhydrous sodium sulfate, filtered, and concentrated. The resulting mixture was purified by normal-phase column chromatography to obtain compound 1-1 (70 mg).

[0672] MS:[M+1] + :483.2. 1 H NMR(400MHz,DMSO-d6)δ(ppm):10.12(s,1H),8.52(s,1H),8.19(s,1H),7.83(s ,1H),7.75-7.68(m,6H),7.41-7.39(m,2H),7.09(d,J=8.0Hz,2H),4.49-4.46( m,1H),4.41(s,2H),3.66-3.64(m,1H),3.53-3.50(m,1H),2.82-2.79(m,1H),2 .20-2.17(m,1H),2.04-2.00(m,1H),1.97-1.93(m,2H),1.16(d,J=8.0Hz,6H).

[0673] Example 2

[0674] Proline derivative compounds 1-2: (R)-3-fluoro-4′-(1-((4-(pentafluorothio)phenyl)aminocarbamate)pyrrolidine-2-ylcarbamate)-[1,1′-biphenyl]-4-carboxylic acid

[0675] Synthesis route:

[0676] Step 1: Preparation of ((4-(pentafluorothio)phenyl)carbamoyl)-D-proline (1-2-A): At 0°C, N,N′-carbonyldiimidazole (162 mg, 1 eq) was added to an acetonitrile solution of 4-(pentafluorothio)aniline (SM1, 219 mg, 1.0 eq). The mixture was stirred and slowly heated to room temperature for a cumulative reaction time of 2 hours. The reaction system was then evaporated to dryness, and the concentrate was dissolved in 5 mL of tetrahydrofuran. D-proline (SM2, 120 mg, 1 eq) and N-methylmorpholine (260 mg, 2 eq) were dissolved in tetrahydrofuran. After stirring and cooling to 0°C, the above-mentioned concentrate in tetrahydrofuran solution was added. The reaction was allowed to proceed for 4 hours until completion. The reaction system was quenched by adjusting the pH to 7-8 with saturated sodium bicarbonate aqueous solution. The mixture was extracted with ethyl acetate to separate the organic phase. The aqueous phase was adjusted to pH 2 with dilute hydrochloric acid and stirred continuously for 20 minutes. The mixture was filtered under reduced pressure, the filter cake was washed with water, and the filter cake was dried at low temperature to obtain compound 1-2-A (180 mg). The crude product was not further purified and was used directly in the next reaction step.

[0677] Step-2: Preparation of methyl(R)-3-fluoro-4′-(1-((4-(pentafluorothio)phenyl)carbamoyl)pyrrolidine-2-ylcarbamoyl)-[1,1′-biphenyl]-4-carboxylate (1-2-B): At room temperature, compound 1-2-A (180 mg, 1 eq) and compound SM3 (220 mg, 1.8 eq) were dissolved in 5 mL of dichloromethane. After stirring and cooling to 0 °C, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI, 133 mg, 1.4 eq) was added. The mixture was slowly heated to room temperature with stirring and reacted for 16 hours. After the reaction was characterized by LCMS, the reaction was quenched with water, and then extracted three times with dichloromethane. The organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered, evaporated to dryness, and purified by normal-phase column chromatography to obtain intermediate 1-2-B (200 mg).

[0678] Step 3: Preparation of (R)-3-fluoro-4′-(1-((4-(pentafluorothio)phenyl)carbamoyl)pyrrolidine-2-ylcarboxamido)-[1,1′-biphenyl]-4-carboxylic acid (1-2): Intermediate 1-2-B (200 mg, 1 eq) was dissolved in a mixture of methanol (4 mL) and water (1 mL) at room temperature. Lithium hydroxide monohydrate (43 mg, 3 eq) was added with stirring at room temperature, and the reaction was stirred for 4 hours until the reaction was complete. The reaction system was placed in an ice-water bath, and the pH was adjusted to 3 with dilute hydrochloric acid. The mixture was extracted three times with ethyl acetate, and the organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and evaporated to dryness. The organic phase was purified by normal-phase column chromatography and reversed-phase column chromatography to obtain compound 1-2 (100 mg).

[0679] MS:[M+1]+:574.1. 1 H NMR (400MHz, DMSO-d6) δ (ppm): 13.16 (s, 1H), 10.20 (s, 1H), 8.80 (s, 1H), 7.92 (t, J = 8.0, 1H), 7.78-7.73 (m, 8H), 7.64-7 .62(m,1H),7.60(s,1H),4.52-4.49(m,1H),3.70-3.66(m,1H),3.60-3.56(m,1H),2.23-2.21(m,1H),2.07-1.93(m,3H).

[0680] Example 3

[0681] Proline derivative compounds 1-3: (R)-N 1 -(4-Isopropylphenyl)-N 2 -(4-(2-keto-1-(2,2,2-trifluoroethyl)-1,2-dihydropyridin-4-yl)phenyl)pyrrolidine-1,2-dicarboxamide

[0682] Synthesis route:

[0683] Step 1: Preparation of 4-bromo-1-(2,2,2-trifluoroethyl)pyridine-2(1H)-one (1-3-A): At room temperature, 4-bromo-2-hydroxypyridine (SM1, 348 mg, 1 eq) and potassium carbonate (828 mg, 6 eq) were suspended in ultradry N,N-dimethylformamide (DMF, 10 mL). After stirring thoroughly for 5 minutes at room temperature, an ultradry DMF solution (1 mL) of 2,2,2-trifluoroethyltrifluoromethanesulfonate (SM2, 556 mg, 1.2 eq) was slowly added dropwise. The reaction was carried out at room temperature for 16 hours. After the reaction was completed, the mixture was quenched with water, extracted three times with ethyl acetate, and the organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered, evaporated to dryness, and purified by normal-phase column chromatography to obtain compound 1-3-A (320 mg).

[0684] Step-2: (R)-N 1 -(4-Isopropylphenyl)-N 2 Preparation of -(4-(2-keto-1-(2,2,2-trifluoroethyl)-1,2-dihydropyridin-4-yl)phenyl)pyrrolidine-1,2-dicarboxamide (1-3): Compound 1-3 was prepared by replacing SM4 with 1-3-A according to Step-3 of Compound 1-1.

[0685] MS:[M+1] + :527.2. 1 H NMR(400MHz,DMSO-d6)δ(ppm):10.20(s,1H),8.19(s,1H),7.73-7.71(m,5H), 7.43-7.39(m,2H),7.13-7.07(m,2H),6.75(d,J=2.4Hz,1H),6.71-6.69(m,1H) ,4.90-4.83(m,2H),4.49-4.45(m,1H),3.67-3.62(m,1H),3.54-3.48(m,1H),2 .84-2.77(m,1H),2.23-2.16(m,1H),2.06-1.89(m,3H),1.16(d,J=6.8Hz,6H).

[0686] Example 4

[0687] Proline derivative compounds 1-4: (2R)-N 2 -(3′-Fluoro-4′-(S-methylsulfinimide)-[1,1′-biphenyl]-4-yl)-N 1 -(4-isopropylphenyl)pyrrolidine-1,2-dicarboxamide

[0688] Synthesis route:

[0689] Step 1: Preparation of 1-(methylsulfinimide)-4-bromo-2-fluorobenzene (1-2-B): At room temperature, 4-bromo-2-fluorothioanisole (SM1, 221 mg, 1 eq) and ammonium carbamate (156 mg, 2 eq) were added to ultradry methanol (5 mL). After stirring thoroughly at 0 °C for 5 minutes, diacetyliodobenzene (644 mg, 2 eq) was slowly added. The mixture was allowed to rise naturally to room temperature with stirring for 1 hour until the reaction was complete. The reaction was quenched with water, extracted three times with ethyl acetate, and the organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered, evaporated to dryness, and purified by normal-phase column chromatography to obtain compound 1-4-A (140 mg).

[0690] Step-2: (2R)-N 2 -(3′-Fluoro-4′-(S-methylsulfinimide)-[1,1′-biphenyl]-4-yl)-N 1 Preparation of (4-isopropylphenyl)pyrrolidine-1,2-dicarboxamide (1-4): Compound 1-4 was prepared by replacing SM4 with 1-4-A according to Step-3 of Compound 1-1.

[0691] MS:[M+1] + :523.2. 1 H NMR (400MHz, DMSO-d6) δ (ppm): 10.17 (s, 1H), 8.19 (s, 1H), 7.89 (t, J = 8.0Hz, 1 H),7.81-7.69(m,6H),7.42-7.38(m,2H),7.10-7.08(m,2H),4.70(d,J=1.6Hz ,1H),4.49-4.46(m,1H),3.68-3.62(m,1H),3.54-3.48(m,1H),3.20(s,3H),2 .84-2.77(m,1H),2.22-2.19(m,1H),2.05-1.90(m,3H),1.16(d,J=6.8Hz,6H).

[0692] Example 5

[0693] Proline derivative compounds 1-5: (R)-N 2 -(4′-(dimethylphosphoryl)-3′-fluoro-[1,1′-biphenyl]-4-yl)-N 1 -(4-isopropylphenyl)pyrrolidine-1,2-dicarboxamide

[0694] Synthesis route:

[0695] Step-1: (R)-N 2 -(4′-(dimethylphosphoryl)-3′-fluoro-[1,1′-biphenyl]-4-yl)-N 1 Preparation of (4-isopropylphenyl)pyrrolidine-1,2-dicarboxamide (1-5): Following the procedure in Step-3 of Example 1, 5-bromo-2,3-dihydroisoindole-1-one was replaced with (4-bromo-2-fluorophenyl)dimethylphosphine oxide to prepare compounds 1-5.

[0696] MS:[M+1]+:522.2. 1 H NMR(400MHz,DMSO-d6)δ(ppm):10.16(s,1H),8.19(s,1H),7.82-7.75(m,5H), 7.70-7.68(m,1H),7.65-7.61(m,1H),7.41-7.39(m,2H),7.09(d,J=8.4Hz,2H ),4.49-4.46(m,1H),3.68-3.63(m,1H),3.54-3.49(m,1H),2.82-2.79(m,1H) ,2.20-2.17(m,1H),2.04-1.92(m,3H),1.74-1.71(m,6H),1.17-1.15(m,6H)..

[0697] Example 6

[0698] Proline derivative compounds 1-6: (R)-3-fluoro-4′-(2-((4-isopropylphenyl)carbamoyl)pyrrolidine-1-carboxamido)-[1,1′-biphenyl]-4-carboxylic acid

[0699] Synthesis route:

[0700] Step 1: Preparation of (R)-2-((4-isopropylphenyl)carbamoyl)pyrrolidine-1-carboxylic acid tert-butyl ester (1-6-A): At room temperature, compound SM1 (500 mg, 1 eq) and (tert-butoxycarbonyl)-D-proline (SM2, 876 mg, 1.1 eq) were dissolved in 15 mL of dichloromethane. After stirring and cooling to 0 °C, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI, 990 mg, 1.4 eq) was added. The mixture was slowly heated to room temperature with stirring and reacted for 16 hours. After the reaction was characterized by LCMS, the reaction was quenched with water, and then extracted three times with dichloromethane. The organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered, evaporated to dryness, and purified by normal phase column chromatography to obtain intermediate 1-6-A (600 mg, yield: 48.8%).

[0701] Step 2: Preparation of (R)-N-(4-isopropylphenyl)pyrrolidine-2-carboxamide (1-6-B): At room temperature, compound 1-6-A (600 mg, 1 eq) was dissolved in 15 mL of dichloromethane. After stirring and cooling to 0 °C, hydrochloric acid (4 M in 1,4-dioxane, 5 mL) was added dropwise. The mixture was slowly heated to room temperature with stirring and reacted for 6 hours. The reaction was characterized by LCMS to indicate completion. The reaction system was concentrated under reduced pressure to obtain the hydrochloride salt of intermediate 1-6-B (400 mg, yield: 95.3%).

[0702] Step 3: Preparation of (R)-3-fluoro-4′-(2-((4-isopropylphenyl)carbamoyl)pyrrolidine-1-carboxamido)-[1,1′-biphenyl]-4-carboxylic acid methyl ester: At room temperature, 4′-amino-3-fluoro-[1,1′-biphenyl]-4-carboxylic acid methyl ester (SM3, 350 mg, 1.0 eq) was dissolved in acetonitrile (5 mL). N,N′-carbonyldiimidazole (278 mg, 1.2 eq) was added to the reaction system at 0 °C. The reaction solution was naturally heated back to room temperature and reacted for 2 h. The reaction system was then evaporated to dryness under reduced pressure, and the concentrate was dissolved in 5 mL of tetrahydrofuran. Compound 1-7-B (365 mg, 1.1 eq) was dissolved in tetrahydrofuran, and N-methylmorpholine (433 mg, 3.0 eq) was added to the system. The mixture was cooled to 0 °C, and the concentrated tetrahydrofuran solution of the compound was added to the system of compound 1-7-B with stirring. The reaction mixture was stirred until the reactants reacted completely. The reaction system was diluted with dichloromethane, and water (25 mL) was added. The mixture was extracted three times with dichloromethane, and the organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and evaporated to dryness. The solution was purified by normal-phase column chromatography to give intermediate 1-6-C (120 mg, yield: 16.7%).

[0703] Step 4: Preparation of (R)-3-fluoro-4′-(2-((4-isopropylphenyl)carbamoyl)pyrrolidine-1-carboxamido)-[1,1′-biphenyl]-4-carboxylic acid (1-6): At room temperature, compound 1-6-C (120 mg, 1.0 eq) was dissolved in a mixed solution of methanol (4 mL) and water (1 mL), and sodium hydroxide (20 mg, 2.0 eq) was added to the reaction system. The mixture was reacted at room temperature for 4 h until the reactants were completely reacted. The reaction solution was adjusted to pH 3 with dilute hydrochloric acid and stirred for about 20 minutes. 25 mL of ethyl acetate was added, and the organic phase was washed with water and saturated sodium chloride aqueous solution, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by column chromatography to give compound 1-6 (37 mg, yield: 31.7%).

[0704] MS:[M+1] +:490.2.1H NMR(400MHz,DMSO-d6)δ(ppm):13.14(s,1H),9.90(s,1H),8.46(s,1H),7.9 1-7.87(m,1H),7.70-7.65(m,4H),7.60-7.57(m,2H),7.53-7.50(m,2H),7. 17-7.15(m,2H),4.49-4.46(m,1H),3.68-3.66(m,1H),3.56-3.54(m,1H),2 .85-2.81(m,1H),2.19-2.16(m,1H),2.03-1.91(m,3H),1.18-1.16(m,6H).

[0705] Example 7

[0706] Proline derivative compounds 1-7: (R)-4′-(1-((4-(dimethylphosphoryl)phenyl)carbamoyl)pyrrolidine-2-carboxamido)-3-fluoro-[1,1′-biphenyl]-4-carboxylic acid

[0707] Synthesis route:

[0708] Step-1 to Step-3: Preparation of (R)-4′-(1-((4-(dimethylphosphoryl)phenyl)carbamoyl)pyrrolidine-2-carboxamido)-3-fluoro-[1,1′-biphenyl]-4-carboxylic acid (1-7): Following the procedures in Step-1 to Step-3 of Example 2, 4-(pentafluorothio)aniline was replaced with (4-aminophenyl)dimethylphosphine oxide to prepare compounds 1-7.

[0709] MS:[M+1] + :524.1. 1 H NMR (400MHz, DMSO-d6) δ (ppm): 13.16 (s, 1H), 10.20 (s, 1H), 8.56 (s, 1H), 7.90-7.86 (m, 1H), 7.74-7.66 (m, 6H), 7.62-7.58 (m,4H),4.52-4.49(m,1H),3.69-3.67(m,1H),3.60-3.55(m,1H),2.23-2.21(m,1H),2.05-1.93(m,3H),1.60-1.57(m,6H).

[0710] Example 8

[0711] Proline derivative compounds 1-8: (R)-N 2-(3′-Fluoro-4′-aminosulfonyl-[1,1′-biphenyl]-4-yl)-N 1 -(4-isopropylphenyl)pyrrolidine-1,2-dicarboxamide

[0712] Synthesis route:

[0713] Step-1: (R)-N 2 -(3′-Fluoro-4′-aminosulfonyl-[1,1′-biphenyl]-4-yl)-N 1 Preparation of (4-isopropylphenyl)pyrrolidine-1,2-dicarboxamide (1-8): Following the procedure in Step-3 of Example 1, 5...

Claims

Compounds represented by formula (I), their stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts, in, X 1 , X 5 are the same or different, independently of one another, selected from CH, C and N; X 2 , X 3 , X 4 identically or differently, independently of one another, selected from CR 1 R 2 , NR 3 and N; R 1 and R 2 are identical or different and independently of each other selected from the group consisting of H, halogen, hydroxyl, thiol, cyano, nitro, and unsubstituted or optionally substituted: C 1-20 alkyl, C 3-20 cycloalkyl, C 3-20 cycloalkenyl, C 3-20 cycloalkynyl, 3-20 membered heterocyclyl, C 3-20 cycloalkoxy, C 1-20 alkoxy, C 3-20 cycloalkoxy, C 3-20 cycloalkenylalkoxy, C 3-20 cycloalkynylalkoxy, 3-20 membered heterocyclylalkoxy; R 3 Selected from H, unsubstituted or optionally substituted groups: C 1-20 Alkyl, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups; Or, when present, R on the same atom 1 and R 2 Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups; Or, when present, R on different atoms 1 R 2 R 3 The two atoms bonded to it together form the following unsubstituted or optionally substituted groups: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups; Each The same or different, independently representing single or double bonds, are conditions that are related to... The bonded groups conform to the valence bond rule; Y 1 Selected from O, S and NH; A is selected from C 6-20 Aryl, C 3-20 Cycloalkyl, 3-20 membered heterocyclic, 3-20 membered heteroaryl, wherein, when present, the atom in A bonded to the NH on the left or the B on the right is C or N; Each R a Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 ); B is selected from C. 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 6-20 Aryl, C 3-20 Cycloalkyl, 3-20 membered heterocyclic, 3-20 membered heteroaryl, wherein when present, the atom in B bonded to the left-hand group A is C or N; Each R b Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 ); Or, when they exist, two R a Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic; Or, when they exist, two R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic; Or, when it exists, R a R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic; Y 2 Selected from O, S and NH; C is selected from C 6-20 Aryl, C 3-20 Cycloalkyl, 3-20 membered heterocyclic, 3-20 membered heteroaryl; Each R c Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(=O)R 4 -C(=O)OR 5 -OC(=O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 ); Or, when they exist, two R c Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic; R f1 R f2 Identical or different, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2- 20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic; R 4 R 5 R 6 R 7 R 8 R 9 R 10 R 11 R 12 R 13 R 14 R 15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 Aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2; m, n, and p may be the same or different, and are independently selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10. The compound, its stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts thereof as claimed in claim 1, wherein, X 1 X 5 They are either the same or different, and are selected independently from CH and N; X 2 X 3 X 4 Same or different, selected independently from CR 1 R 2 NR 3 CR 1 and N; R 1 and R 2 They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-12 Alkyl, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group, C 3-12 Cycloalkyloxy, C 1-12 Alkyloxy, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, 3-12 membered heterocyclic oxy group; R 3 Selected from H, unsubstituted or optionally substituted groups: C 1-12 Alkyl, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic groups; When present, R on the same atom 1 and R 2 Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic groups; Or, when present, R on different atoms 1 R 2 R 3 The two atoms bonded to it together form the following unsubstituted or optionally substituted groups: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group. The compound, its stereoisomer, deuterated product, solvate, prodrug, metabolite, or pharmaceutically acceptable salt thereof as claimed in claim 1 or 2, wherein, One or two of them One is a double bond, the others are single bonds; for example, Selected from 1, 2, 3 or 4 selected from R 1 R 2 and R 3 The substituents replace the following groups: The compound, its stereoisomer, deuterated product, solvate, prodrug, metabolite, or pharmaceutically acceptable salt thereof as described in any one of claims 1-3, wherein: Selected from 1, 2, 3 or 4 selected from R 1 R 2 and R 3 The substituents replace the following groups: The compound, its stereoisomer, deuterated product, solvate, prodrug, metabolite, or pharmaceutically acceptable salt thereof as described in any one of claims 1-4, wherein, A is selected from C 6-12 Aryl, C 3-12 Cycloalkyl, 3-12-membered heterocyclic, 5-12-membered heteroaryl, such as phenyl, naphthyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, cyclohexyl, piperidinyl, piperazinyl, hexahydropyrimidinyl, hexahydropyridazinyl, 1,2-dihydropyridinyl (e.g.) ), 1,4-dihydropyridyl, morpholinyl; or, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic, and 5-12 membered heteroaryl groups can be selected from bicyclic groups, such as fused rings, bridged rings, or spirocyclic groups, for example, spiro[3.3]heptyl, spiro[3.4]octyl, spiro[4.4]nonyl, spiro[4.5]decyl, and spiro[5.5]undecyl; Each R a Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 ); B is selected from C. 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 6-12 Aryl, C 3-12 Cycloalkyl, 3-12-membered heterocyclic, 5-12-membered heteroaryl, such as vinyl, ethynyl, propynyl, phenyl, naphthyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, cyclohexyl, piperidinyl, piperazinyl, hexahydropyrimidinyl, hexahydropyridazinyl, 1,2-dihydropyridinyl (e.g.) ), 1,4-dihydropyridyl, morpholinyl; or, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic, and 5-12 membered heteroaryl groups can be selected from bicyclic groups, such as fused rings, bridged rings, or spirocyclic groups, for example, spiro[3.3]heptyl, spiro[3.4]octyl, spiro[4.4]nonyl, spiro[4.5]decyl, and spiro[5.5]undecyl; Each R b Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 ); When they exist, two R a Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic groups, such as azircyclopentenyl, etc. Or, when they exist, two R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic groups, such as azircyclopentenyl, etc. Or, when it exists, R a R b Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 heteroaryl, 3-12 heterocyclic. The compound, its stereoisomer, deuterated product, solvate, prodrug, metabolite, or pharmaceutically acceptable salt according to any one of claims 1-5, wherein, Y 2 Selected from O, S and NH; C is selected from C 6-12 Aryl, C 3-12 Cycloalkyl, 3-12-membered heterocyclic, 5-12-membered heteroaryl, such as phenyl, naphthyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, cyclohexyl, piperidinyl, piperazinyl, hexahydropyrimidinyl, hexahydropyridazinyl, 1,2-dihydropyridinyl (e.g.) ), 1,4-dihydropyridyl, morpholinyl; or, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic, and 5-12 membered heteroaryl groups can be selected from bicyclic groups, such as fused rings, bridged rings, or spirocyclic groups, for example, spiro[3.3]heptyl, spiro[3.4]octyl, spiro[4.4]nonyl, spiro[4.5]decyl, and spiro[5.5]undecyl; Each R c Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 aryloxy group, 5-12 membered heteroaryloxy group, 3-12 membered heterocyclic oxy group, NH2, -C(=O)R 4 -C(=O)OR 5 -OC(=O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 ); Or, when they exist, two R c Together with the atoms it is attached to, it forms the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic; R 4 R 5 R 6 R 7 R 8 R 9 R 10 R 11 R 12 R 13 R 14 R 15 The same or different groups, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-12 Alkyl, C 2-12 alkenyl, C 2-12 alkynyl group, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, C 6-12 Aryl, 5-12 membered heteroaryl, 3-12 membered heterocyclic, C 1-12 Alkyloxy, C 2-12 alkenyloxy group, C 2-12 alkynyloxy group, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, C 6-12 Aryloxy group, 5-12-membered heteroaryloxy group, 3-12-membered heterocyclic oxy group, NH2; m, n, and p may be the same or different, and are independently selected from 0, 1, 2, 3, 4, 5, or 6. The compound, its stereoisomer, deuterated product, solvate, prodrug, metabolite, or pharmaceutically acceptable salt thereof as described in any one of claims 1-6, wherein, The compound has the structure shown in the following formula: Among them, Y 1 Y 2 X 1 X 2 X 3 X 4 X 5 A, B, C, R a R b R c R f1 R f2 m, n, and p have the definitions described in any one of claims 1-4. The compound, its stereoisomer, deuterated product, solvate, prodrug, metabolite, or pharmaceutically acceptable salt thereof as claimed in any one of claims 1-7, wherein, The compound has the structure shown in the following formula: in, Each R g They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups, C 3-20 Cycloalkyloxy, C 1-20 Alkyloxy, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, 3-20 membered heterocyclic oxy group; Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups; Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups; v can be the same or different, and can be independently selected from 0, 1, 2, 3, 4 or 5; Y 1 Y 2 A, B, C, R a R b R c R f1 R f2 The definitions of m, n, and p are as described in any one of claims 1-7. The compound, its stereoisomer, deuterated product, solvate, prodrug, metabolite, or pharmaceutically acceptable salt thereof as claimed in any one of claims 1-8, wherein, The compound has the structure shown in the following formula: in, Each R g They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups, C 3-20 Cycloalkyloxy, C 1-20 Alkyloxy, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, 3-20 membered heterocyclic oxy group; Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups; Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups; v can be the same or different, and can be independently selected from 0, 1, 2, 3, 4 or 5; Each t1 and t2 may be the same or different, and is independently selected from 0, 1, 2, 3, 4 or 5; Y 1 Y 2 A, B, C, R a R b R c R f1 R f2 The definitions of m, n, and p are as described in any one of claims 1-8. The compound, its stereoisomer, deuterated product, solvate, prodrug, metabolite, or pharmaceutically acceptable salt thereof as claimed in claim 8 or 9, wherein: Each R g They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-12 Alkyl, C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group, C 3-12 Cycloalkyloxy, C 1-12 Alkyloxy, C 3-12 Cycloalkyloxy, C 3-12 Cycloalkenyloxy, C 3-12 Cycloalkynyloxy group, 3-12 membered heterocyclic oxy group; Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic groups; Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-12 cycloalkyl, C 3-12 Cycloalkenyl, C 3-12 Cycloalkynyl, 3-12 membered heterocyclic group. The compound, its stereoisomer, deuterated product, solvate, prodrug, metabolite, or pharmaceutically acceptable salt thereof as claimed in claim 10, wherein: Each R g They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl, C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, 3-6 membered heterocyclic, C 3-6 Cycloalkyloxy, C 1-6 Alkyloxy, C 3-6 Cycloalkyloxy, C 3-6 Cycloalkenyloxy, C 3-6 Cycloalkynyloxy group, 3-6 membered heterocyclic oxy group; Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, 3-6 membered heterocyclic groups; Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, 3-6 membered heterocyclic group. The compound, its stereoisomer, deuterated product, solvate, prodrug, metabolite, or pharmaceutically acceptable salt thereof as described in any one of claims 1-11, wherein, The compound has the structures shown below (XI-1) to (X-XVIVI-3): Among them, R h Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3- 20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(O)R 4 -C(O)OR 5 -OC(O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 ); R i Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 2-20 alkenyl, C 2-20 alkynyl group, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, C 6-20 Aryl, 5-20 membered heteroaryl, 3-20 membered heterocyclic, C 1-20 Alkyloxy, C 2-20 alkenyloxy group, C 2-20 alkynyloxy group, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, C 6-20 aryloxy group, 5-20 membered heteroaryloxy group, 3-20 membered heterocyclic oxy group, NH2, -C(=O)R 4 -C(=O)OR 5 -OC(=O)R 6 -S(=O)(=NH)R 7 -S(=O)2R 7 -S(=O)2OR 8 -OS(=O)2R 9 -B(OR) 10 (OR) 11 -P(=O)R 12 R 13 -P(O)(OR) 14 (OR) 15 ); U 1 U 8 U 9 They are either the same or different, and are selected independently from CH and N; U 2 —U 3 "Selected from the following groups:" U 4 —U 5 "Selected from the following groups:" U 6 —U 7 "Selected from the following groups:" Each t1 and t2 may be the same or different, and is independently selected from 0, 1, 2, 3, 4 or 5; Y 1 Y 2 R a R b R c R g The definitions of m, n, p, and v are as described in any one of claims 1-11. The compound, its stereoisomer, deuterated product, solvate, prodrug, metabolite, or pharmaceutically acceptable salt thereof as described in any one of claims 1-12, wherein, Y 1 Selected from O and S; Y 2 Selected from O and S; U 1 U 8 U 9 They are either the same or different, and are selected independently from CH and N; U 2 —U 3 "Selected from the following groups:" U 4 —U 5 "Selected from the following groups:" U 6 —U 7 "Selected from the following groups:" Each R a Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxetyl, oxetyl, oxetyl, -P(=O)(C) 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH; Each R b Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxetyl, oxetyl, oxetyl, -P(=O)(C) 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl), S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH; Each R c Identical or different, independently selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxecyclobutyl, oxecyclopentyl, oxecyclohexyl, morpholinyl, -P(=O)(C 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH; Each R g They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl, C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, 3-6 membered heterocyclic, C 3-6 Cycloalkyloxy, C 1-6 Alkyloxy, C 3-6 Cycloalkyloxy, C 3-6 Cycloalkenyloxy, C 3-6 Cycloalkynyloxy group, 3-6 membered heterocyclic oxy group; Or, when present, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, 3-6 membered heterocyclic groups; Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, 3-6 membered heterocyclic groups; R h Selected from SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxetyl, oxetyl, oxetyl, -P(=O)(C) 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl), S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH; R i Selected from halogens, hydroxyl groups, mercapto groups, cyano groups, nitro groups, oxo (=O), thio (=S), SF3, SF5, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), C 3-6 Cycloalkyl groups (e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl), 3-6 membered heterocyclic groups (e.g., aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine, aziridine), -P(=O)(C 1-6 Alkyl)2、-C(=O)(C 1-6 Alkyl group), -S(=O)(=NH)C 1-6 Alkyl groups, -S(=O)2NH2, -COOH; Each m, n, p, v, t1, t2 is the same or different, and is independently selected from 0, 1, or 2. The compound, its stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts thereof as claimed in claim 1, wherein, The compound has a structure as shown in formula (YI): Among them, each R k1 or R k2 They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-20 Alkyl, C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups, C 3-20 Cycloalkyloxy, C 1-20 Alkyloxy, C 3-20 Cycloalkyloxy, C 3-20 Cycloalkenyloxy, C 3-20 Cycloalkynyloxy group, 3-20 membered heterocyclic oxy group; Or, R k1 and R k2 Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-20 cycloalkyl, C 3-20 Cycloalkenyl, C 3-20 Cycloalkynyl, 3-20 membered heterocyclic groups; X 1 X 2 X 3 X 4 X 5 Y 1 Y 2 A, B, C, R a R b R c R f1 R f2 The definitions of m, n, and p are as described in any one of claims 1-13. The compound, its stereoisomer, deuterated product, solvate, prodrug, metabolite, or pharmaceutically acceptable salt thereof as claimed in claim 14, wherein, The compound has the structures shown in formulas (YI-1) to (YV-3): Among them, each R k1 or R k2 Whether the same or different, each R k1 or R k2 They may be the same or different, and are independently selected from H, halogen, hydroxyl, mercapto, cyano, nitro, and the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl, C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3-6 Cycloalkynyl, 3-6 membered heterocyclic, C 3-6 Cycloalkyloxy, C 1-6 Alkyloxy, C 3-6 Cycloalkyloxy, C 3-6 Cycloalkenyloxy, C 3-6 Cycloalkynyloxy group, 3-6 membered heterocyclic oxy group; Or, R k1 and R k2 Together with the atoms they bond to, they form the following groups, either unsubstituted or optionally substituted: C 3-6 cycloalkyl, C 3-6 Cycloalkenyl, C 3- 6-cyclic alkynyl group, 3-6 membered heterocyclic group; X 1 X 2 X 3 X 4 X 5 Y 1 Y 2 A, B, C, R a R b R c R f1 R f2 The definitions of m, n, and p are as described in any one of claims 1-14. The compound, its stereoisomer, deuterated product, solvate, prodrug, metabolite, or pharmaceutically acceptable salt thereof as claimed in claim 14 or 15, wherein, Y 1 Selected from O; Y 2 Selected from O; A is selected from the following groups that can be substituted: B is selected from the following groups that can be substituted: Of the above groups, the right half contains This indicates that an R is connected to the right end. b R connected to the right end b Selected from: -COOH, C is selected from the following groups that can be substituted: Of the above groups, the right half contains This indicates that an R is connected to the right end. c R connected to the right end c Selected from the following groups, either unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl groups (e.g., monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aziridine, aziridine, piperidinyl, oxecyclobutyl, oxecyclopentyl, oxecyclohexyl, morpholinyl, -P(=O)(C 1-6 Alkyl)2、-C(=O)(C 1-6 alkyl); Each R a The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3; Each R b The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, are either unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, tetrahydrofuranyl, pyrrolyl, tetrahydropyranyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -COOH; Each R c The following groups, selected independently from H, halogen, OH, NH2, cyano, SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylamino, aziridine, oxacyclobutyl, tetrahydrofuranyl, pyrrolyl, tetrahydropyranyl, piperidinyl, piperazine, morpholinyl, thiomorpholinyl, methoxy, ethoxy, propoxy, isopropoxy, methylthio, ethylthio, propylthio, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -COOH; R f1 R f2 Identical or different, independently selected from H, and the following groups, unsubstituted or optionally substituted: C 1-6 Alkyl groups (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl), halogenated C 1-6 Alkyl, cyclopropyl, cyclobutyl; Each R g The following groups, selected independently from H, halogen, OH, NH2, cyano, oxo (=O), SF3, SF5, without substitution or optionally substituted, are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, hydroxymethyl, hydroxyethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, aziridine, oxaziridine, tetrahydrofuranyl, pyrrolyl, methoxy, ethoxy, propoxy, isopropoxy, methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, diisopropylamino, cyclopropylNH-, -C(O)CH3, -C(O)NH2, -COOH; Or, two R atoms on the same atom g Together with the atoms they bond to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, cyclopentyl, oxetyl, thiohexacyclobutyl, aziridine, oxetyl, and aziridine; Or, when present, two R atoms on different atoms g Together with the atoms they bond to, they form the following groups with no substitution or optional substitution: cyclopentyl, cyclohexyl, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, aziridine, oxetyl, thiohexyl, thiohexyl, and aziridine. Each R k1 or R k2 The same or different, independently selected from H, halogen, hydroxyl, cyano, and the following groups, unsubstituted or optionally substituted: methyl, ethyl, propyl, isopropyl, monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl, trifluoropropyl, cyclopropyl, cyclobutyl, cyclopentyl; Or, R k1 and R k2 Together with the atoms they bond to, they form the following groups with no substitution or optional substitution: cyclopropyl, cyclobutyl, and cyclopentyl; Each m, n, p, v, t1, t2 is the same or different, and is independently selected from 0, 1, or 2. The compound of claim 1, its stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts thereof, wherein the compound is selected from the compounds shown in Table 1 or Table 2, their stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts thereof. A pharmaceutical composition wherein, The pharmaceutical composition comprises at least one of the compounds of any one of claims 1-17, their stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts thereof. Use of at least one of the compounds, stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts thereof, as described in any one of claims 1-17, or the pharmaceutical composition of claim 18, in the preparation of a medicament for the prevention and / or treatment of diseases or conditions associated with GIP or GIPR. A method for preventing and / or treating a disease, the method comprising administering to a subject a therapeutically effective amount of a compound of any one of claims 1-17, its stereoisomers, deuterated derivatives, solvates, prodrugs, metabolites, or pharmaceutically acceptable salts thereof, or a pharmaceutical composition of claim 18, wherein the disease is preferably a disease or condition associated with GIP or GIPR.

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