Method for preparing 8-aminooctanoic acid and use thereof
By reacting ethyl 2-(6-halohexyl)malonate with phthalimide, and combining optimized solvent and acidic conditions, the problems of expensive raw materials and environmental pollution in the existing synthesis of 8-aminooctanoic acid have been solved, and efficient and environmentally friendly industrial production has been achieved.
WO2026113552A1PCT designated stage Publication Date: 2026-06-04HUANGGANG LUBAN PHARM
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Patent Information
- Application Number
- PCT/CN2025/117803
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-11-28
- Filing Date
- 2025-08-29
- Publication Date
- 2026-06-04
AI Technical Summary
Technical Problem
The existing 8-aminooctanoic acid synthesis process suffers from problems such as high raw material prices, excessive waste, significant environmental impact, and unsuitability for large-scale industrial production.
Method used
Compound IV was generated by reacting ethyl 2-(6-halohexyl)malonate with phthalimide, followed by decarboxylation and hydrolysis to obtain 8-aminooctanoic acid. The types and concentrations of solvents, bases and acids were optimized to improve reaction efficiency and product purity.
Benefits of technology
A low-cost, simple, safe, and environmentally friendly synthesis process for 8-aminooctanoic acid has been achieved, which is suitable for large-scale industrial production, with high product yield and easy separation and purification.
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Smart Images
Figure CN2025117803_04062026_PF_FP_ABST
Abstract
Provided is a method for preparing 8-aminooctanoic acid. Starting from diethyl 2-(6-halohexyl)malonate (III), a crude product of 8-aminooctanoic acid is obtained by a condensation reaction with phthalimide, hydrolysis with dilute sulfuric acid, decarboxylation, and deprotection. High-purity 8-aminooctanoic acid is then obtained by recrystallization in a solvent. The method has the advantages of simplified process, easy availability of raw materials, high yield, ease of separation and purification, less waste, cost-efficiency, ease of industrialization, and the like.
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