7-fluoro-tetrahydroisoquinoline derivatives and uses thereof

7-fluoro-tetrahydroisoquinoline derivatives serve as effective positive allosteric modulators of the D1 dopamine receptor, improving treatment of disorders like schizophrenia and Parkinson's disease by enhancing receptor modulation with improved drug-like properties.

WO2026114347A1PCT designated stage Publication Date: 2026-06-04IGNIS THERAPEUTICS (SUZHOU) LTD
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
IGNIS THERAPEUTICS (SUZHOU) LTD
Filing Date
2025-11-28
Publication Date
2026-06-04

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Abstract

The present disclosure relates to compounds which are the positive allosteric modulators of human D1 dopamine receptor as well as pharmaceutical compositions comprising these compounds and methods of treatment of diseases or medical conditions treated via modulation of human D1 dopamine receptor by administration of these compounds or the pharmaceutical compositions.
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