Preparation process for melatonin by combined enzymatic hydrolysis extraction of tomato raw materials
The combined enzymatic hydrolysis and purification process effectively addresses low extraction efficiency and impurity issues in melatonin extraction from tomatoes, achieving high-purity melatonin suitable for health foods.
WO2026115533A2PCT designated stage Publication Date: 2026-06-04ZIRAOUI NOUR-EDDINE
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- ZIRAOUI NOUR-EDDINE
- Filing Date
- 2026-04-20
- Publication Date
- 2026-06-04
AI Technical Summary
Technical Problem
Existing methods for extracting melatonin from tomatoes face low extraction efficiency due to encapsulation by cell wall components, melatonin degradation, and high impurity content, limiting industrial application and purity.
Method used
A combined enzymatic hydrolysis process using tomatoes, black ginger, and rice germ polyamines, along with pectinase and cellulase, followed by gel chromatography purification and stabilization, to disrupt cell walls, enhance melatonin release, and achieve high purity.
Benefits of technology
The process results in high-purity melatonin with a content of 98.2-99.1% and low impurity content of <1.5%, suitable for health foods, with improved extraction efficiency and stability.
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Smart Images
Figure IB2026053864_04062026_PF_FP_ABST
Abstract
The invention discloses a process for preparing melatonin from tomato raw materials via combined enzymatic hydrolysis extraction, belonging to the technical field of melatonin preparation. The process comprises: S1, preparing materials including 100–680 parts of tomatoes, 10–120 parts of black ginger, 20–120 parts of rice germ polyamines, 10–100 parts of pectinase, 5–50 parts of cellulase, 10–30 parts of a compound enzyme preparation, 3–30 parts of an extraction solvent, 2–55 parts of a pH regulator, 1–40 parts of a stabilizer, 10–110 parts of gel chromatography packing, and 100–2000 parts of deionized water; and S2, pretreating raw materials, wherein tomatoes are processed into slurry and black ginger is processed into powder (80–120 mesh).The process improves product stability and storage life, and is green, safe, simple, controllable, suitable for industrial production, and economical, providing an efficient route for high-purity melatonin preparation.
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