Body patch sheet

Abstract

The present invention addresses the problem of providing a body patch sheet capable of giving, to a user, a sufficient cool feeling, a comfortable use feeling with less strong stimulation, and a tangible feeling of effectiveness in improving mental clarity. A body patch sheet according to the present invention has a gel layer. The gel layer contains (A) carbon dioxide gas, (B) a TRPM8 agonist, and (C) water. The content of component (A) in the gel layer is 5 g / m2 or more. The content of component (B) in the gel layer is 0.001-0.20 mass%. The thickness of the gel layer is 1.5 mm or more. Component (B) preferably contains: (B1) menthoxypropanediol or menthyl lactate; and (B2) menthol.

Description

Body adhesive sheets

[0001] This invention relates to a sheet for application to the body.

[0002] Articles that provide a cooling sensation when applied to the human body are known. For example, Patent Document 1 proposes a sheet-type coolant that can cool the body by utilizing the latent heat of water when applied to the human body. The present applicant has also previously proposed a sheet-type cosmetic having a gel layer and containing carbon dioxide and menthol, etc. (see Patent Documents 2 and 3).

[0003] Japanese Patent Publication No. 2002-241747 US2020 / 100991A1 US2020 / 054536 A1

[0004] The present invention provides a body adhesive sheet having a gel layer. In one embodiment of the present invention, the gel layer preferably contains the following components (A), (B), and (C): (A) carbon dioxide (B) TRPM8 agonist (C) water. In one embodiment of the present invention, the content of component (A) in the gel layer is 5 g / m² ２ The above is preferable. In one embodiment of the present invention, the content of component (B) in the gel layer is preferably 0.001% by mass or more and 0.20% by mass or less. In one embodiment of the present invention, the thickness of the gel layer is preferably 1.5 mm or more. Detailed description of the invention

[0005] According to the sheet-type preparation described in Patent Document 1, although the temperature of the skin surface directly beneath the application site decreases, the effect of improving blood flow at the application site and the feeling of refreshment in the head are insufficient. The sheet-type cosmetic preparations described in Patent Documents 2 and 3 provide a sufficiently high blood flow promotion effect even when applied to areas where the skin is thin, the density of temperature receptors is high, and the skin is sensitive to hot and cold stimuli. However, depending on the application site, a strong irritation may be felt, which may result in an unpleasant and comfortable feeling during use. Furthermore, if the amount of menthol, a substance that promotes blood circulation, is reduced in order to reduce strong irritation, the feeling of a refreshing effect on the head is difficult to obtain.

[0006] This invention relates to a body-adhesive sheet that is less likely to cause strong irritation, provides a comfortable user experience, and gives the feeling of having a refreshing effect on the head.

[0007] The present invention will be described below based on its preferred embodiments. The body adhesive sheet of the present invention is typically used by being directly applied to human skin. By applying the body adhesive sheet of the present invention to human skin, as described later, a sufficient cooling sensation and comfortable feeling can be perceived without causing strong irritation, the cooling sensation is sustained, and furthermore, the user can perceive the effect of having a clear head. The inventors incorporated a large amount of cooling agent in order to give the user a sufficient cooling sensation, but found that this resulted in excessive sensory stimulation depending on the application site of the sheet. For example, with conventional sheets of this type, it was customary to apply the sheet to the forehead in order to give the user the feeling of having a clear head, but it was found that in such cases, the user may experience excessive sensory stimulation. On the other hand, the idea of ​​giving the user the feeling of having a clear head when the sheet is applied to a part of the body other than the forehead has not existed before.

[0008] The body-adhesive sheet of the present invention has a gel layer. In this invention, the adhesive properties of the gel layer are utilized to directly adhere the body-adhesive sheet to human skin. When the body-adhesive sheet is applied, the gel layer is in direct contact with the human skin, making it possible to absorb the components contained in the gel layer transdermally into the human body. Therefore, in this invention, the gel layer contains the main components of the sheet of the present invention. In particular, the gel layer preferably contains the following components (A), (B), and (C): (A) Carbon dioxide (B) TRPM8 agonist (C) Water These components will be described below.

[0009] In the gel layer of the sheet for body attachment of the present invention, carbon dioxide gas, which is component (A), is contained. When the sheet for body attachment of the present invention is attached to the skin, the blood circulation promoting action is enhanced by the carbon dioxide gas and the action is sustained. A sheet having a gel layer containing carbon dioxide gas is conventionally known. The sheet for body attachment of the present invention has one feature in that the amount of carbon dioxide gas contained in the gel layer is larger than before. Specifically, in the sheet for body attachment of the present invention, the content of carbon dioxide gas in the gel layer is 5 g / m ２ or more, preferably. By containing such a large amount of carbon dioxide gas in the gel layer, a high-concentration carbon dioxide gas can be supplied to the user over a long period of time. As a result, it brings the advantage of enhancing the blood circulation promoting effect and increasing the blood flow rate. These advantages are extremely advantageous from the viewpoint of making the user perceive the effect of feeling refreshed. Moreover, surprisingly, even when the sheet for body attachment of the present invention is attached to a body part other than the forehead, the user can perceive the effect of feeling refreshed. From the viewpoint of making these advantages more prominent, the content of carbon dioxide gas in the gel layer is 5.5 g / m ２ or more, more preferably, and 6 g / m ２ or more, even more preferably. The higher the content of carbon dioxide gas in the gel layer, the more desirable it is from the viewpoint of enhancing the blood circulation promoting effect. On the other hand, from the viewpoint of manufacturing in consideration of the solubility of carbon dioxide gas, the content of carbon dioxide gas in the gel layer is preferably 80 g / m ２ or less, more preferably 60 g / m ２ or less, even more preferably 40 g / m ２ or less, and even more preferably 20 g / m ２ or less. Considering the above points, the content of carbon dioxide gas in the gel layer is preferably 5 g / m ２ or more and 80 g / m ２ or less, more preferably 5.5 g / m ２ or more and 60 g / m ２ or less, even more preferably 6 g / m ２ or more and 40 g / m ２ or less, and even more preferably 6 g / m２ 20g / m or more ２ The following is even more preferable. The method for incorporating carbon dioxide into the gel layer will be described later.

[0010] The amount of carbon dioxide contained in the gel layer can be measured, for example, by the following method. If the viscosity of the gel layer is low (1000 Pa·s or less), the amount of carbon dioxide can be measured using a carbon dioxide electrode at room temperature (25°C) without diluting the gel layer. On the other hand, if the viscosity of the gel layer is high (greater than 1000 Pa·s), the gel layer is placed in a lidded container containing an alkaline solution and thoroughly immersed to trap the carbon dioxide as carbonate in the aqueous solution. Then, the pH of the aqueous solution is made acidic with an acidic buffer solution. The carbon dioxide concentration of the aqueous solution at room temperature (25°C) is measured using a carbon dioxide electrode. The carbon dioxide concentration in the gel layer is calculated based on the obtained carbon dioxide concentration, the mass of the gel layer, and the volume of the aqueous solution. Furthermore, the concentration per unit area (m²) is calculated based on the thickness of the gel layer. ２ The volume of the gel layer per unit area (g / m²) is calculated, and by multiplying this by the carbon dioxide concentration in the gel layer, the amount of carbon dioxide per unit area of ​​the sheet (g / m²) is calculated. ２ Calculate the result.

[0011] As described above, one of the features of the body adhesive sheet of the present invention is that the gel layer contains a large amount of carbon dioxide. The concentration of carbon dioxide in the gel layer is preferably 750 ppm or more, more preferably 1000 ppm or more, and even more preferably 1250 ppm or more, from the viewpoint of enhancing the blood circulation promoting effect and allowing the user to perceive the effect of a clear head. The higher the concentration of carbon dioxide in the gel layer, the easier it is for the user to perceive the effect of a clear head, so this is preferable, but in practical terms, the intended purpose can be sufficiently achieved if the concentration of carbon dioxide in the gel layer is as high as 2500 ppm. In this specification, "ppm" is a value based on mass.

[0012] In order to include a sufficient amount of carbon dioxide in the gel layer, it is advantageous to set a high basis weight of the gel layer. From this perspective, the basis weight of the gel layer should be 1500 g / m². ２ Preferably, it should be 1700 g / m² or more. ２It is even more preferable that the amount be greater than or equal to 1900 g / m². ２ It is even more preferable that the above conditions are met. The higher the basis weight of the gel layer, the more advantageous it is for carbon dioxide content, but a basis weight of 3200 g / m² is preferable. ２ If the concentration is high enough, it becomes possible to incorporate an amount of carbon dioxide into the gel layer sufficient to fully achieve the effects of the present invention. The basis weight of the gel layer can be adjusted by the amount of water, which is component (C), and the type and amount of gelling agent.

[0013] In relation to the basis weight of the gel layer, increasing the thickness of the gel layer is advantageous from the viewpoint of containing a sufficient amount of carbon dioxide in the gel layer. From this viewpoint, the thickness of the gel layer is preferably 1.5 mm or more, more preferably 2 mm or more, and even more preferably 3 mm or more. The higher the thickness of the gel layer, the more advantageous it is for carbon dioxide content. However, if the thickness becomes excessively large, the adhesiveness and feel of the body-adhesive sheet of the present invention may decrease. From this viewpoint, the thickness of the gel layer is preferably 10 mm or less, more preferably 8 mm or less, and even more preferably 6 mm or less. The thickness of the gel layer is measured under no load using a laser displacement meter.

[0014] The TRPM8 agonist, component (B) contained in the gel layer, is an agonist that acts on TRPM8, a cold receptor among the temperature-sensitive TRP channels present in the body. There are no restrictions on the type of TRPM8 agonist; any compound that activates the TRPM8 channel is acceptable. Examples of TRPM8 agonists include menthol such as L-menthol and DL-menthol, menthanediol, cineole, menthyl glyceryl ether, menthyl lactate, menthyl succinate, menthyl glutarate, menthylpyrrolidone carboxylic acid, ethyl menthanecarboxamide, menthanecarbonylglycine ethyl ester, menthyl ethylaminooxalic acid, menthol glycerin acetal, butylcyclohexanone, isopulegol, trimethylisopropylbutanamide, menthoxypropanediol, camphor, ishirin, N-(ethoxycarbonylmethyl)-3-p-menthanecarboxamide, and N-ethyl-p-menthane-3-carboxamide. Alternatively, plant or essential oils such as peppermint oil, spearmint oil, and eucalyptus oil containing TRPM8 agonists may be used. These TRPM8 agonists may be used individually or in combination of two or more types.

[0015] The TRPM8 agonist, through interaction with carbon dioxide as described above, enhances the duration of the blood circulation-promoting effect and provides a cooling sensation to the user. As a result of diligent research, the inventors have found that when the carbon dioxide content in the gel layer is above a predetermined amount, even a relatively small amount of TRPM8 agonist in the gel layer can provide a sufficient blood circulation-promoting effect and produce a refreshing head effect. Furthermore, by using a small amount of TRPM8 agonist, when the body adhesive sheet of the present invention is applied to an area sensitive to cold and pain, such as the forehead, it is possible to provide the user with a pleasant cooling sensation without causing strong irritation, and also to perceive a refreshing head effect. From the viewpoint of reliably exhibiting these advantages, the TRPM8 agonist content in the gel layer is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 0.05% by mass or more. Furthermore, from the viewpoint of preventing excessive irritation to the user caused by the TRPM8 agonist, the TRPM8 agonist content in the gel layer is preferably 0.20% by mass or less, and more preferably 0.15% by mass or less.

[0016] The amount of TRPM8 agonist in the gel layer is determined based on the extent to which the user perceives the cooling sensation, comfortable feel, and refreshing effect caused by the interaction between the large amount of carbon dioxide contained in the gel layer and the TRPM8 agonist. The inventors' research has shown that using a combination of two or more substances as the TRPM8 agonist is advantageous in order to provide users with a balanced perception of these sensations. In particular, using a combination of two substances as the TRPM8 agonist results in a comfortable feel without strong irritation, even when the body adhesive sheet of the present invention is applied to the forehead, a part of the body that is highly sensitive to cold and pain, due to the further interaction between the large amount of carbon dioxide contained in the gel layer and the TRPM8 agonist. Furthermore, even when applied to the forehead or other parts of the body, the user can effectively perceive a refreshing effect.

[0017] In particular, using a combination of two TRPM8 agonists with different TRPA1 activity levels is advantageous because it effectively provides users with a sufficient cooling sensation, a comfortable feel with minimal irritation, and a noticeable head-clearing effect. This advantage becomes even more pronounced when combining a TRPM8 agonist with high TRPA1 activity with a TRPM8 agonist with low TRPA1 activity.

[0018] From the above viewpoint, it is preferable that the TRPM8 agonist contains the following components (B1) and (B2): (B1) menthoxypropanediol or menthyl lactate (B2) menthol, and it is even more preferable that the TRPM8 agonist consists of components (B1) and (B2). Component (B1) is a TRPM8 agonist with low TRPA1 activity. Component (B2) is a TRPM8 agonist with high TRPA1 activity. TRPA1 is a type of ion channel and is a receptor mainly involved in pain sensation, temperature sensation, and responses to chemical stimuli.

[0019] When the TRPM8 agonist contains the above-mentioned components (B1) and (B2), from the viewpoint of providing users with a good balance of sufficient cooling sensation, a comfortable feel with minimal irritation, and a noticeable effect of clearing the head, the mass ratio of component (B2) / component (B1) is preferably 0.05 or higher, more preferably 0.1 or higher, even more preferably 0.25 or higher, and even more preferably 0.8 or higher. From a similar viewpoint, the mass ratio of component (B2) / component (B1) is preferably 10 or less, more preferably 9 or less, even more preferably 8 or less, even more preferably 4 or less, and particularly preferably 3 or less. Taking the above points into consideration, the mass ratio of component (B2) / component (B1) is preferably 0.05 or more and 10 or less, more preferably 0.1 or more and 9 or less, even more preferably 0.25 or more and 8 or less, even more preferably 0.8 or more and 4 or less, and particularly preferably 0.8 or more and 3 or less.

[0020] From the perspective of enabling users to perceive, in a well-balanced manner, a more sufficient sense of coolness, a more comfortable feeling of use with less strong irritation, and a sense of experiencing the effect of making the head feel clearer, in relation to the mass ratio of component (B2) / component (B1), the content of component (B1) in the gel layer is preferably 0.001% by mass or more, more preferably 0.0015% by mass or more, and still more preferably 0.002% by mass or more, provided that the content of the TRPM8 agonist in the gel layer is within the above-described range. From the same perspective, the content of component (B1) in the gel layer is preferably 0.191% by mass or less, more preferably 0.165% by mass or less, and still more preferably 0.143% by mass or less.

[0021] On the other hand, from the perspective of enabling users to perceive, in a well-balanced manner, a more sufficient sense of coolness, a more comfortable feeling of use with less strong irritation, and a sense of experiencing the effect of making the head feel clearer, the content of component (B2) in the gel layer is preferably 0.0005% by mass or more, more preferably 0.005% by mass or more, and still more preferably 0.0075% by mass or more, provided that the content of the TRPM8 agonist in the gel layer is within the above-described range. From the same perspective, the content of component (B2) in the gel layer is preferably 0.182% by mass or less, more preferably 0.159% by mass or less, and still more preferably 0.136% by mass or less.

[0022] Since the gel layer contains water as component (C), it is in the state of a hydrogel. The water contained in the gel layer preferably has a content of 60% by mass or more, more preferably 65% by mass or more, and still more preferably 70% by mass or more, from the perspective of containing a high concentration of carbon dioxide gas in the gel layer. Also, the water content in the gel layer is preferably 90% by mass or less, more preferably 87% by mass or less, and still more preferably 85% by mass or less, from the perspective of maintaining the gel state of the gel layer. Details of the gelling agent for making the gel layer into a hydrogel state will be described later.

[0023] In the body-applied sheet of the present invention, it is preferable that the gel layer further contains the following component (D): (D) ester oil. By containing ester oil in the gel layer, the blood circulation promoting effect can be further enhanced. Examples of ester oils include monoglycerides of saturated or unsaturated fatty acids, diglycerides of saturated or unsaturated fatty acids, and triglycerides of saturated or unsaturated fatty acids. The number of carbon atoms of the fatty acid residue in the glyceride is preferably 2 or more and 18 or less, and more preferably 6 or more and 18 or less. Specific examples of ester oils include monoester oils such as isopropyl myristate, isononyl isononanoate, and isotridecyl isononanoate; diester oils such as neopentyl glycol dicaprate; and triesters composed of triglycerides of saturated or unsaturated fatty acids having 6 or more and 18 or less carbon atoms, such as glyceryl tri(caprylyl / caprate), glyceryl tri(2-ethylhexanoate), and glyceryl trioleate. These ester oils may be used alone or in combination of two or more. Among the above various ester oils, it is preferable to use glyceryl tri(caprylyl / caprate), isopropyl myristate, or isononyl isononanoate from the viewpoint of good compatibility with component (A) and component (B).

[0024] When blending ester oil in the gel layer, the content of ester oil is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, and still more preferably 0.1% by mass or more, from the viewpoint of enhancing the persistence of the cool feeling while alleviating the stimulating feeling of the TRPM8 agonist and imparting the effect of making the head feel refreshed. Also, the content of ester oil in the gel layer is preferably 3% by mass or less, more preferably 2.8% by mass or less, and still more preferably 2.5% by mass or less, from the viewpoint of not suppressing the cool feeling of the TRPM8 agonist too much, not hindering the blood circulation promoting effects of carbon dioxide gas, menthol, etc., and imparting an effective feeling of the effect of making the head feel refreshed.

[0025] Adjusting the content of ester oil, which is component (D), in relation to the content of TRPM8 agonist, which is component (B) as described above, is advantageous in that the skin irritation of TRPM8 agonist is suppressed, the duration of the cooling sensation is improved, and the adsorption of TRPM8 agonist to the pillow is suppressed. From this viewpoint, it is preferable to set the mass ratio of component (B) / component (D) in the gel layer to 0.05 or more, more preferably to 0.06 or more, and even more preferably to 0.07 or more. From a similar viewpoint, it is preferable to set the mass ratio of component (B) / component (D) in the gel layer to 0.5 or less, more preferably to 0.45 or less, even more preferably to 0.4 or less, and even more preferably to 0.3 or less. Considering the above points, it is preferable that the mass ratio of component (B) / component (D) be 0.05 or more and 0.5 or less, more preferably 0.06 or more and 0.45 or less, even more preferably 0.07 or more and 0.4 or less, and even more preferably 0.07 or more and 0.3 or less.

[0026] When component (B) contains the above-mentioned components (B1) and (B2), it is preferable to set the mass ratio of component (B1) / component (D) to 0.01 or more and 0.5 or less, particularly 0.025 or more and 0.45 or less, and especially 0.05 or more and 0.4 or less, from the viewpoint of further enhancing the blood circulation promoting effect, alleviating the stimulating sensation of the TRPM8 agonist, and allowing the user to fully perceive the effect of a clear head. From a similar viewpoint, it is preferable to set the mass ratio of component (B2) / component (D) to 0.05 or more and 0.5 or less, particularly 0.06 or more and 0.45 or less, and especially 0.07 or more and 0.4 or less.

[0027] In addition to the components mentioned above, the gel layer may also contain other components commonly used in cosmetics and pharmaceuticals. Examples of such components include powder components, humectants, water-soluble polymers, thickeners, film-forming agents, UV absorbers, metal ion sequestering agents, alcohols, sugars, amino acid derivatives, organic amines, synthetic resin emulsions, known blood circulation promoters, skin nutrients, vitamins, antioxidants, antioxidant aids, preservatives, pigments, and fragrances.

[0028] The gel layer contains a gelling agent. The gelling agent retains water, which is component (C), thereby obtaining a gel layer made of hydrogel. Preferably, the gelling agent contains a water-soluble anionic polymer. It is also preferable that the gelling agent contains a crosslinking agent for the water-soluble anionic polymer. The water-soluble anionic polymer and its crosslinking agent form a dense network structure that forms the basic framework of the gel layer, and water is retained within this network structure.

[0029] Examples of water-soluble anionic polymers include polymers having carboxyl groups, sulfate groups, and phosphate groups. Specifically, these include poly(meth)acrylic acids, carboxyvinyl polymers and their salts; anionic cellulose derivatives such as carboxymethylcellulose and carboxyethylcellulose and their salts; carrageenan, alginic acid and their salts, and anionic starch derivatives. From the viewpoint of high water retention, sufficient gel strength, and flexibility that can follow the contours of the skin and body movements, it is preferable that the water-soluble anionic polymer contains at least one selected from poly(meth)acrylic acids, carboxymethylcellulose, carrageenan, and their salts. Furthermore, it is even more preferable to use carboxymethylcellulose, sodium carboxymethylcellulose, polyacrylic acid, and sodium polyacrylate because they are relatively inexpensive and readily available industrially.

[0030] The content of the anionic polymer in the gel layer is preferably 0.5% by mass or more and 25% by mass or less, in order to impart sufficient gel strength to the gel layer. From this viewpoint, the content of the anionic polymer in the gel layer is more preferably 3% by mass or more and 10% by mass or less.

[0031] Examples of crosslinking agents for water-soluble anionic polymers include metal ion compounds, cationic polymers, and polyfunctional epoxy compounds. The choice of crosslinking agent should depend on the reactivity between the functional groups of the anionic polymer to be crosslinked and the crosslinking agent.

[0032] Examples of the metal ion compounds include oxides, hydroxides, and salts containing aluminum, magnesium, calcium, or potassium. Specifically, examples include aluminum hydroxide, potassium alum, aluminum sulfate, aluminum oxide, aluminum glycinate, aluminum acetate, aluminum lactate, aluminum stearate, hydrated aluminum silicate, aluminum metasilicate, magnesium aluminometasilicate, magnesium chloride, magnesium stearate, calcium carbonate, calcium hydroxide, kaolin, synthetic hydrotalcite, and potassium hydroxide. These compounds may be used individually or in combination of two or more. When carboxymethylcellulose or a salt thereof is selected as the anionic polymer, it is preferable to use aluminum ion compounds such as magnesium aluminometasilicate and aluminum hydroxide as crosslinking agents. From the viewpoint of sufficiently crosslinking the anionic polymer, the content of the crosslinking agent in the gel layer is preferably 0.01% by mass or more and 10% by mass or less, more preferably 0.05% by mass or more and 5% by mass or less, and even more preferably 0.1% by mass or more and 2% by mass or less.

[0033] The body-adhesive sheet of the present invention may have a gel layer supported on one surface of a sheet substrate. Examples of sheet substrates include woven fabrics, nonwoven fabrics, knitted fabrics, synthetic resin films, and water-resistant paper. Laminate sheets made from a combination of two or more of these can also be used. Specific examples of sheet substrates include woven or nonwoven fabrics containing synthetic fibers such as polyamide, polypropylene, polyester, polyethylene, polystyrene, polyurethane, or polyolefin, or natural fibers such as silk, cotton, linen, rayon, or collagen. In addition, synthetic resin sheets made from polyamide, polypropylene, polyester, polyethylene, and polyurethane, as well as thin film sheets made from pullulan and starch, can also be used. From the viewpoint of ensuring sufficient strength for use, the thickness of the sheet substrate may be approximately 0.05 mm to 2.0 mm under no load.

[0034] The body-adhesive sheet of the present invention may have a release layer laminated on the surface of the gel layer. If the body-adhesive sheet of the present invention has, for example, a sheet substrate and a gel layer disposed on one side thereof, the release layer can be disposed on the side of the gel layer opposite to the side facing the sheet substrate. The release layer is used for the purpose of protecting the gel layer in the body-adhesive sheet before use. When using the body-adhesive sheet, the release layer is peeled off from the gel layer to expose one side of the gel layer, and the sheet is attached to the human body by using the adhesive properties of the gel layer to bring that side into contact with the human body.

[0035] Examples of substrates for the release layer include polyester films such as polyethylene terephthalate film and polybutylene terephthalate film; polyolefin films such as polyethylene film and polypropylene film; and laminated paper in which a synthetic resin film such as polyethylene is laminated onto paper such as kraft paper, glassine paper, or fine paper. It is more preferable that one side of the release layer is hydrophobized, such as by silicone treatment. In this case, the release layer is laminated with the gel layer such that the hydrophobized side faces the gel layer.

[0036] The body-adhesive sheet of the present invention is preferably airtightly contained in a packaging container before use, in order to maintain the concentration of carbon dioxide contained in the gel layer. From this viewpoint, the packaging container is preferably made of a material that is poorly permeable to carbon dioxide. For example, a carbon dioxide permeability of 50 cc / m³ ２ It is preferable that the packaging container is made of a material with a day-atm (ASTM D-1434) or lower.

[0037] To incorporate carbon dioxide into the gel layer, a body-adhesive sheet can be placed inside a packaging container, and the packaging container can be sealed while it is filled with carbon dioxide. A specific method is described, for example, in Japanese Patent Publication No. 2021-31105, an earlier application of the present applicant.

[0038] The body adhesive sheet of the present invention is used by being applied to human skin other than the scalp. Specific application sites include, for example, various parts of the face such as the forehead, cheeks, nose, ears, and mouth, and the upper body such as the neck (especially the nape), shoulders, back, waist, chest, upper arms, and forearms. Applying it to the forehead, neck (especially the nape), or shoulders is particularly preferable as it enhances the effects of the present invention. However, there is no prejudice to applying the body adhesive sheet of the present invention to the lower limbs such as the calves, thighs, ankles, and soles of the feet. Notably, even when the body adhesive sheet of the present invention is not applied to the forehead but to other parts of the body, it is possible to make the user perceive the effect of a clearer head. Moreover, even when the body adhesive sheet of the present invention is applied to other parts of the body other than the forehead, such as the neck or shoulders, it is possible to make the user perceive the effect of a clearer head without perceiving excessively strong stimulation. Of course, even if the body adhesive sheet of the present invention is applied to the forehead, it is possible to make the user perceive the effect of having a clear head. Thus, the body adhesive sheet of the present invention is particularly useful as a sheet for cooling the human head. In this specification, "cooling the human head" is a concept that encompasses not only physically cooling the head by applying the body adhesive sheet of the present invention to the human head (for example, by cooling with the heat of vaporization of water), but also making the user perceive the effect of having a clear head by applying the body adhesive sheet of the present invention to a part of the body other than the head. Therefore, "head cooling sheet" refers to a sheet that is applied to the human body and used to cool the head.

[0039] As mentioned earlier, the body adhesive sheet of the present invention contains a large amount of carbon dioxide in the gel layer, resulting in a higher blood circulation promoting effect compared to conventional water-containing gel sheets. Therefore, even if the sheet is made smaller, it is possible to make the user perceive a pleasant cooling sensation and a feeling of mental clarity. From this perspective, the area of ​​the gel layer in the body adhesive sheet of the present invention is 40 cm². ２ Preferably, it should be 45 cm or more. ２ It is even more preferable that the length be greater than or equal to 50 cm. ２It is even more preferable that the above conditions are met. Furthermore, the area of ​​the gel layer in the body-adhesive sheet of the present invention is 90 cm². ２ Preferably, it is 85 cm ２ More preferably, the following is true: 80 cm ２ The following is even more preferable. The area mentioned above refers to the area of ​​the gel layer in a plan view, even when the body-adhesive sheet of the present invention has a sheet substrate and / or a release layer in addition to the gel layer.

[0040] In relation to the area described above, if the gel layer in the body-adhesive sheet of the present invention is rectangular, the length of one side is preferably 3 cm or more, more preferably 3.5 cm or more, and even more preferably 4 cm or more. Furthermore, the length of one side is preferably 30 cm or less, more preferably 25 cm or less, and even more preferably 22.5 cm or less. Note that the shape of the gel layer in the body-adhesive sheet of the present invention in plan view is not limited to a rectangle, but may be other shapes, such as a circle, an ellipse, or a polygon other than a rectangle. Also, if the body-adhesive sheet of the present invention has a sheet substrate and / or a release layer in addition to the gel layer, the shape of the gel layer and the shape of the sheet substrate and / or release layer may be the same or different.

[0041] With respect to the embodiments described above, the present invention further discloses the following body adhesive sheet: <1> A body adhesive sheet having a gel layer, wherein the gel layer contains the following components (A), (B), and (C): (A) carbon dioxide (B) TRPM8 agonist (C) water, and the content of component (A) in the gel layer is 5 g / m² ２The above, wherein the content of component (B) in the gel layer is 0.001% by mass or more and 0.20% by mass or less, and the thickness of the gel layer is 1.5 mm or more, a sheet for application to the body. <2> The sheet for application to the body according to <1>, wherein the content of component (B) in the gel layer is 0.01% by mass or more and 0.20% by mass or less. <3> The sheet for application to the body according to <1> or <2>, wherein the content of component (B) in the gel layer is 0.05% by mass or more and 0.15% by mass or less. <4> The sheet for application to the body according to any one of <1> to <3>, wherein component (B) contains component (B1) and component (B2): (B1) menthoxypropanediol or menthyl lactate (B2) menthol. <5> The sheet for application to the body according to <4>, wherein the content of component (B1) in the gel layer is 0.001% by mass or more and 0.191% by mass or less. <6> A body adhesive sheet according to <4> or <5>, wherein the content of component (B1) in the gel layer is 0.0015% by mass or more and 0.165% by mass or less. <7> A body adhesive sheet according to any one of <4> to <6>, wherein the content of component (B1) in the gel layer is 0.002% by mass or more and 0.143% by mass or less. <8> A body adhesive sheet according to any one of <4> to <7>, wherein the content of component (B2) in the gel layer is 0.0005% by mass or more and 0.182% by mass or less. <9> A body adhesive sheet according to any one of <4> to <8>, wherein the content of component (B2) in the gel layer is 0.005% by mass or more and 0.159% by mass or less. <10> A body adhesive sheet according to any one of <4> to <9>, wherein the content of component (B2) in the gel layer is 0.0075% by mass or more and 0.136% by mass or less. <11> A body adhesive sheet according to any one of <4> to <10>, wherein the mass ratio of component (B2) / component (B1) is 0.05 or more and 10 or less. <12> A body adhesive sheet according to any one of <4> to <11>, wherein the mass ratio of component (B2) / component (B1) is 0.1 or more and 9 or less. <13> A body adhesive sheet according to any one of <4> to <12>, wherein the mass ratio of component (B2) / component (B1) is 0.25 or more and 8 or less.<14> A body patch according to any one of <4> to <13>, wherein the mass ratio of component (B2) / component (B1) is 0.8 or more and 4 or less. <15> A body patch according to any one of <4> to <14>, wherein component (B1) is menthoxypropanediol and component (B2) is menthol. <16> A body patch according to any one of <1> to <15>, wherein the gel layer further contains the following component (D): (D) ester oil, and the mass ratio of component (B) / component (D) is 0.05 or more and 0.5 or less. <17> A body patch according to <16>, wherein the mass ratio of component (B) / component (D) is 0.06 or more and 0.45 or less. <18> A body patch according to <16> or <17>, wherein the mass ratio of component (B) / component (D) is 0.07 or more and 0.4 or less. <19> A body adhesive sheet according to any one of <16> to <18>, wherein the content of component (D) in the gel layer is 0.01% by mass or more and 3% by mass or less. <20> A body adhesive sheet according to any one of <16> to <19>, wherein the content of component (D) in the gel layer is 0.05% by mass or more and 2.8% by mass or less. <21> A body adhesive sheet according to any one of <16> to <20>, wherein the content of component (D) in the gel layer is 0.1% by mass or more and 2.5% by mass or less. <22> A body patch according to any one of <1> to <3>, wherein component (B) is component (B1) and component (B2): (B1) menthoxypropanediol or menthyl lactate (B2) menthol The gel layer further contains the following component (D): (D) ester oil, and the mass ratio of component (B1) / component (D) is 0.01 or more and 0.5 or less. <23> A body patch according to <22>, wherein the mass ratio of component (B1) / component (D) is 0.025 or more and 0.45 or less. <24> A body patch according to <22> or <23>, wherein the mass ratio of component (B1) / component (D) is 0.05 or more and 0.4 or less.<25> A body patch according to any one of <1> to <3>, wherein component (B) is component (B1) and component (B2): (B1) menthoxypropanediol or menthyl lactate (B2) menthol The gel layer further contains the following component (D): (D) ester oil, and the mass ratio of component (B2) / component (D) is 0.05 or more and 0.5 or less. <26> A body patch according to <25>, wherein the mass ratio of component (B2) / component (D) is 0.06 or more and 0.45 or less. <27> A body patch according to <25> or <26>, wherein the mass ratio of component (B2) / component (D) is 0.07 or more and 0.4 or less. <28> The content of component (A) in the gel layer is 5 g / m². ２ 80g / m or more ２ A body-adhesive sheet as described in any one of the following <1> through <27>.

[0042] <29> The content of component (A) in the gel layer is 5.5 g / m ２ 60g / m or more ２ A body adhesive sheet according to any one of the following <1> to <28>: <30> The amount of component (A) in the gel layer is 6 g / m ２ 40g / m or more ２ A body adhesive sheet as described in any one of the following <1> to <29>: <31> The amount of component (A) in the gel layer is 6 g / m ２ 20g / m or more ２A body adhesive sheet according to any one of the following <1> to <30>. <32> A body adhesive sheet according to any one of <1> to <31>, wherein the concentration of component (A) in the gel layer is 750 ppm or more. <33> A body adhesive sheet according to any one of <1> to <32>, wherein the concentration of component (A) in the gel layer is 1000 ppm or more. <34> A body adhesive sheet according to any one of <1> to <33>, wherein the concentration of component (A) in the gel layer is 1250 ppm or more. <35> A body adhesive sheet according to any one of <1> to <34>, wherein the content of component (C) in the gel layer is 60% by mass or more and 90% by mass or less. <36> A body adhesive sheet according to any one of <1> to <35>, wherein the content of component (C) in the gel layer is 65% by mass or more and 87% by mass or less. <37> A body adhesive sheet according to any one of <1> to <36>, wherein the content of component (C) in the gel layer is 70% by mass or more and 85% by mass or less. <38> A body adhesive sheet according to any one of <1> to <37>, wherein the gel layer contains a gelling agent. <39> A body adhesive sheet according to <38>, wherein the gelling agent contains a water-soluble anionic polymer. <40> A body adhesive sheet according to <39>, wherein the content of the water-soluble anionic polymer in the gel layer is 0.5% by mass or more and 25% by mass or less. <41> A body adhesive sheet according to <39> or <40>, wherein the gelling agent contains a crosslinking agent for the water-soluble anionic polymer. <42> A body adhesive sheet according to <41>, wherein the content of the crosslinking agent in the gel layer is 0.01% by mass or more and 10% by mass or less. <43> The basis weight of the gel layer is 1500 g / m². ２ The above is a body-adhesive sheet as described in any one of <1> to <42>. <44> The basis weight of the gel layer is 1500 g / m². ２ More than 3200g / m ２ A body-adhesive sheet as described in any one of the following <1> to <43>: <45> The basis weight of the gel layer is 1700 g / m² ２ More than 3200g / m ２A body-adhesive sheet as described in any one of the following <1> to <44>: <46> The basis weight of the gel layer is 1900 g / m² ２ More than 3200g / m ２ A body-adhesive sheet according to any one of the following <1> to <45>: <47> A body-adhesive sheet according to any one of the following <1> to <46>, wherein the thickness of the gel layer is 1.5 mm or more and 10 mm or less. <48> A body-adhesive sheet according to any one of the following <1> to <47>, wherein the thickness of the gel layer is 2 mm or more and 8 mm or less. <49> A body-adhesive sheet according to any one of the following <1> to <48>, wherein the thickness of the gel layer is 3 mm or more and 6 mm or less. <50> An area of ​​40 cm² ２ 90cm or more ２ A body-adhesive sheet according to any one of the following <1> to <49>: <51> A body-adhesive sheet according to any one of the following <1> to <50>, wherein the gel layer is supported on one surface of the sheet substrate. <52> A body-adhesive sheet according to any one of the following <1> to <51>, wherein the sheet substrate is a woven fabric, nonwoven fabric, knitted fabric, synthetic resin film, or water-resistant paper. <53> A body-adhesive sheet according to any one of the following <1> to <52>, which is airtightly contained in a packaging container before use. <54> A carbon dioxide permeability of 50 cc / m ２ - The body-adhesive sheet according to <53>, wherein the packaging container is made of a material that is 75% or less of day-atm (ASTM D-1434). <55> The body-adhesive sheet according to any one of <1> to <54>, which is used to cool the head when attached to the human body.

[0043] The present invention will be described in more detail below with reference to examples. However, the scope of the present invention is not limited to these examples. Unless otherwise specified, "%" means "mass%".

[0044] [Examples 1 to 18 and Comparative Examples 1 to 6] Uncrosslinked hydrated gel stock solutions were prepared according to the formulations shown in Tables 1 to 3 below, and body adhesive sheets were made using these hydrated gel stock solutions. Specifically, succinic acid aqueous solution was mixed with sodium carboxymethylcellulose, polyvinyl alcohol, dried aluminum hydroxide, magnesium aluminometasilicate, glycerin, glutamic acid, and methyl parahydroxybenzoate and put into a kneader. Next, propylene glycol in which TRPM8 agonist (component (B)) had been heated and dissolved was added and mixed to prepare an uncrosslinked hydrated gel stock solution. The obtained hydrated gel stock solution was sandwiched between a polyethylene film and a nonwoven fabric, and the thickness of the gel layer was adjusted using a Baker-type applicator. Next, the gel was aged at 50°C for two days to promote the ionic crosslinking reaction of the hydrated gel. In the table, "WS-5," one of the components (B), is the trade name for N-(ethoxycarbonylmethyl)-3-p-menthanecarboxamide, a TRPM8 agonist manufactured by Renessenz LLC. The body-adhesive sheets thus obtained were die-cut into 5 cm x 10 cm rectangles and placed in pillow packaging made of synthetic resin film with aluminum vapor deposition. The air in the packaging was replaced with carbon dioxide by 90% or more by volume before sealing. The carbon dioxide content and concentration in the gel layer of the examples and comparative examples were changed by adjusting the thickness and / or basis weight and / or water content of the gel layer.

[0045] The body adhesive sheets obtained in this manner were removed from their packaging, and the thickness, basis weight, carbon dioxide content, and concentration of the gel layer were promptly measured. The body adhesive sheets removed from their packaging were then promptly applied to the forehead and back of the neck of the subjects. After 180 minutes, the degree of skin irritation, the duration of the cooling sensation, and the perceived effect of refreshing the head were evaluated according to the following criteria, and the rate of increase in blood flow was measured. The subjects were three healthy adult men and women. The results are shown in Tables 1 to 3 below.

[0046] [Low level of skin irritation] ○: Comfortable to use with no irritation. △: Slightly irritating. ×: Causes strong irritation (cannot be worn continuously).

[0047] [Duration of Cooling Sensation] ◎: Cooling sensation lasts for a long time. ○: Cooling sensation lasts. △: Cooling sensation lasts somewhat. ×: Cooling sensation does not last very long.

[0048] [Perceived effect of clearing the mind] ◎: A noticeable feeling of mental clarity. ○: A feeling of mental clarity. △: A slight feeling of mental clarity. ×: No feeling of mental clarity.

[0049] [Increase in Blood Flow] After acclimatizing subjects for 20 minutes in an environment of approximately 25±1°C and 50±5%RH, blood flow in the medial forearm was measured using a laser speckle blood flow meter and recorded as the value before measurement. Blood flow was measured 5 minutes, 30 minutes, 60 minutes, and 120 minutes after each gel sheet was applied to the medial forearm. The percentage increase in blood flow after application was calculated, with the blood flow before application set to 100.

[0050]

[0051]

[0052]

[0053] As is clear from the results shown in Tables 1 to 3, the body adhesive sheets of each example, when applied to the user's skin, can provide a sufficient and continuous cooling sensation without causing excessive irritation, and also allow the user to experience a refreshing effect on their head. This effect is particularly pronounced when two types of compounds are used in combination as TRPM8 agonists. In particular, as is clear from the comparison between Example 1 and Example 16, when menthoxypropanediol and menthol are used as TRPM8 agonists in combination (Example 1), compared to when other combinations are used (Example 16), a sufficient and continuous cooling sensation can be provided without causing excessive irritation to the user, and the user can experience a refreshing effect on their head. Furthermore, while conventional methods increased blood flow by using high concentrations of TRPM8 agonists, as in each example, it can be seen that even when using low concentrations of TRPM8 agonists, increasing the amount of carbon dioxide per unit area increases the amount of blood flow increase. In contrast, in Comparative Example 1, which had a high TRPM8 agonist content, users experienced strong stimulation, and their sense of comfort was diminished. This trend was also observed in Comparative Example 3, which had a higher carbon dioxide content than Comparative Example 1. In Comparative Example 2, which did not contain TRPM8 agonist, users did not experience strong stimulation, but they did not feel the effect of clearing their heads. In Comparative Example 4, which had a low carbon dioxide content, users did not experience strong stimulation due to the low TRPM8 agonist content, but they did not feel the effect of clearing their heads due to the low blood circulation promoting effect of carbon dioxide.

[0054] As described in detail above, the body adhesive sheet of the present invention provides users with sufficient and sustained cooling sensation, a comfortable user experience with minimal irritation, and a noticeable effect of clearing the head.

Claims

1. A body adhesive sheet having a gel layer, wherein the gel layer contains the following components (A), (B), and (C): (A) carbon dioxide (B) TRPM8 agonist (C) water, and the content of component (A) in the gel layer is 5 g / m² ２ The above is true, wherein the content of component (B) in the gel layer is 0.001% by mass or more and 0.20% by mass or less, and the thickness of the gel layer is 1.5 mm or more, for use as a body adhesive sheet.

2. The body patch according to claim 1, wherein component (B) contains component (B1) and component (B2): (B1) menthoxypropanediol or menthyl lactate (B2) menthol.

3. The body adhesive sheet according to claim 2, wherein the mass ratio of component (B2) / component (B1) is 0.05 or more and 10 or less.

4. The body adhesive sheet according to claim 1 or 2, wherein the gel layer further contains the following component (D): (D) ester oil, and the mass ratio of component (B) / component (D) is 0.05 or more and 0.5 or less.

5. The body adhesive sheet according to claim 1 or 2, wherein the concentration of component (A) in the gel layer is 750 ppm or more.

6. The body adhesive sheet according to claim 1 or 2, wherein the content of component (C) in the gel layer is 60% by mass or more and 90% by mass or less.

7. The basis weight of the gel layer is 1500 g / m². ２ The body-adhesive sheet according to claim 1 or 2.

8. Area is 40 cm² ２ 90cm or more ２ The body-adhesive sheet according to claim 1 or 2, which is as follows:

9. A body-adhesive sheet according to claim 1 or 2, which is applied to the human body and used to cool the head.

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