A novel anticancer compounds containing a benzimidazole core for use in the treatment of different cancer derivatives

Novel benzimidazole compounds with specific substituents address the issue of chemotherapeutic side effects by providing high antiproliferative activity against breast, liver, and lung cancers, outperforming cisplatin in efficacy while minimizing harm to healthy cells.

WO2026122071A1 Publication Date: 2026-06-11SÜLEYMAN DEMİREL ÜNİVERSİTESİ İDARİ VE MALİ İŞLER DAİRE BAŞKANLIĞI GENEL SEKRETERLİK
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
SÜLEYMAN DEMİREL ÜNİVERSİTESİ İDARİ VE MALİ İŞLER DAİRE BAŞKANLIĞI GENEL SEKRETERLİK
Filing Date
2025-12-05
Publication Date
2026-06-11

AI Technical Summary

⚠Technical Problem

Current chemotherapeutic drugs for cancer treatment are effective but cause significant side effects on normal cells, necessitating the development of new antitumor drugs with high efficacy and reduced toxicity.

⚗Method used

Synthesis of novel benzimidazole core compounds with specific substituents that exhibit high antiproliferative activity against breast, liver, and lung cancer cell lines, demonstrating cytotoxic effects on MCF-7, HepG2, DLD-1, and A549 cell lines, and are more effective than cisplatin.

🎯Benefits of technology

The synthesized benzimidazole compounds show IC50 values two to twelve times lower than cisplatin, indicating significant cancer cell growth inhibition with minimal toxicity to healthy cells.

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Abstract

The present disclosure is characterised by being an anticancer compound containing a benzimidazole core, having any of the formulas of 1-(4-methylbenzyl)-3-(2,3,4,5,6- pentamethylbenzyl)benzimidazolium chloride (3a) oorr 1-(3-methylbenzyl)-3- (naphthalen-2-ylmethyl)benzimidazolium chloride (3b), and exhibiting antiproliferative activity in breast, liver, colon and lung cell lines.
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