Methods, systems, and devices for fluid collection

Abstract

The present disclosure provides methods, systems, and devices for removing a bodily fluid and / or biological sample from a subject to be used for testing, diagnostics, and / or other purposes. The device described herein may safely and effectively remove earwax from a subject's ear in an automated manner.

Description

[0001] METHODS, SYSTEMS, AND DEVICES FOR FLUID COLLECTION

[0002] BACKGROUND

[0003] [1] Earwax, also known by the medical term cerumen, is a waxy substance secreted in the human ear canal that protects the ear. Excess earwax can build up in the ear canal, potentially causing a blockage and can in some cases cause hearing loss. Earwax removal is frequently performed using inefficient manual methods, such as by using a rubber bulb syringe to squirt water or saline solution into the ear canal. Such methods when self-administered may be ineffective and even dangerous if incorrectly performed. A subject may need to visit a healthcare provider’s office to receive effective earwax removal care, frequently also performed manually, which can be costly and inconvenient for the subject as well as difficult for the provider. Thus, there is a need for automated low-cost device and method that efficiently removes earwax or other bodily fluid of a subject at a point-of-care setting.

[0004] SUMMARY

[0005] [2] The invention is defined in the independent claims, and preferred features are set out in the dependent claims. In an aspect, the present disclosure provides a device for receiving a biological sample of a subject, comprising: a lid at least partially covering a first curved body concentric with a second curved body; and a canister vessel removably coupled to the lid, wherein the lid is fluidically coupled to the canister vessel, and wherein the canister vessel is configured to receive the biological sample of the subject. In some embodiments, the device comprises a filter fluidically coupled to the lid, the canister vessel, or a combination thereof. In some embodiments, the filter is disposed in the lid. In some embodiments, the filter is disposed within the first curved body. In some embodiments, the filter is configured to swell when the filter absorbs the biological sample of the subject. In some embodiments, the filter self-seals to the first curved body. In some embodiments, the first curved body concentric with the second curved body provides a flow of a fluid of at least about 14.5 liters per minute between the lid, the filter, the canister vessel, or any combination thereof. In some embodiments, the first curved body concentric with the second curved body provides a laminar flow of fluid between the lid, the filter, the canister vessel, or a combination thereof. In some embodiments, the filter is covered by a third body. In some embodiments, the biological sample comprises ear wax or a bodily fluid of the subject. In some embodiments, the canister vessel, the lid, or any combination thereof is fluidically coupled to a pump. In some embodiments, the canister vessel, the lid, or any combination thereof is fluidically coupled to a valve, wherein the valve is fluidically coupled to the atmosphere. In some embodiments, the valve decreases suction of the pump when the valve is opened.

[0006] [3] Another aspect of the disclosure provides a device for attenuating sound, comprising: a first body comprising an inlet coupled to an output of a pump; a second body comprising an outlet, wherein the second body is coupled to the first body, and wherein an axis of the outlet is offset from an axis of the inlet; and a material disposed within the first body and the second body configured to attenuate sound of the pump. In some embodiments, the material comprises a polymer fiber, foam, cotton, or any combination thereof. In some embodiments, the outlet is fluidically coupled to the atmosphere. In some embodiments, the first body and / or the second body is injection molded. In some embodiments, the sound of the pump is attenuated by at least about 10 decibels (dB). In some embodiments, the first body or the second body comprise a length of about 1 / 32 of a standing wave frequency of the sound of the pump. In some embodiments, the first body or the second body are made of acrylonitrile butadiene styrene (ABS). In some embodiments, the first body is ultrasonically welded to the second body.

[0007] [4] Another aspect of the disclosure provides a device for attenuating sound, comprising: an inlet configured to receive a fluid from a pump of a fluidic system; an outlet; a body comprising an interior fluidically coupled to the inlet and the outlet; and a flow control structure comprising a plurality of elongate channels; wherein the flow control structure is arranged within the interior of the body such that the flow control structure defines a plurality of flow paths from the inlet to the outlet through the elongate channels. Each flow path passes from one end of the elongate channels to another (e.g. opposite) end of the elongate channels at least twice. The flow control structure may be configured to attenuate sound emitted by the pump. As explained herein, the flow control structure defining the flow paths can enable the sound attenuator to be manufactured more reliably and to provide greater control over the sound attenuation achieved.

[0008] [5] The term “elongate channels” as used herein may refer to channels that have a length (in a flow direction) that is significantly longer than a width (perpendicular to the length or flow direction). An elongate channel may be, but is not limited to, a channel whose length is at least 2, at least 3, at least 4, at least 5, at least 10, at least 20, or at least 30 times larger than its width. By virtue of being elongate, elongate channels have two ends (e.g. a first end and a second end). These may be co-located with, near to / adjacent, or separate from, ends of the flow control structure.

[0009] [6] The term “flow path” as used herein refers to a path for fluid (such as the fluid received at the inlet) to flow along. As used herein, flow paths passing “from one end of the elongate channels to another end of the elongate channels at least twice” refers to flow paths that pass from a location near or proximate a first end of the elongate channels, to another location near or proximate a second end of the elongate channels, and then back towards the location near the first end. Each flow path may pass through one elongate channel, or two or more channels.

[0010] [7] In some embodiments, the flow paths pass from one end of the elongate channels to another end of the elongate channels at least three times. In some embodiments, the flow paths comprise one or more sigmoidal portions. As used herein, the term “sigmoidal portion” refers to a portion of the flow path that has a sigmoidal shape. A sigmoidal portion may be referred to as an S-shaped portion (or at least two “U-shaped” portions). In other words, each flow path changes direction or turns at least twice. Each turn in the flow path may have an angle of at least around 45 degrees, at least around 90 degrees, at least around 135 degrees, or at least around 180 degrees. The shape of each flow path may be referred to as tortuous, curved, twisting, meandering, sinusoidal, serpentine or winding. Each flow path may be a curved path or a path formed of linear segments. A flow path may include more than one sigmoidal or S-shaped portions (or more than two “U-shaped” portions). The length of each flow path between the inlet and the outlet may be significantly greater (e.g. at least two, three or four times larger) than a spatial distance between the inlet and the outlet. The sigmoidal portion may be defined by one or more of the elongate channels. In some embodiments, each flow path passes through at least two or at least three of the elongate channels. For example, a flow path may pass through three or more elongate channels in alternating directions, thereby defining a sigmoidal shape.

[0011] Additionally or alternatively, the flow control structure may be arranged such that a sigmoidal portion of a flow path is defined by one or two elongate channels and one or more other parts of the interior of the body (such as a chamber or other conduit).

[0012] [8] In some embodiments, the body comprises: a first chamber fluidically coupled to the inlet via a first portion of the channels; and a second chamber fluidically coupled to the outlet via a second portion of the channels; wherein the first chamber is fluidically coupled to the second chamber via a third portion of the channels; and wherein each flow path passes through the first and second chambers. Each flow path may pass through one of the first portion of channels, one of the second portion of channels, and at least one of the third portion of channels - for example, the fluid flow may (re)circulate between the first and second chambers (via the third portion of channels) before passing to the outlet via the second portion of channels.

[0013] [9] In some embodiments, the flow control structure comprises a matrix of parallel elongate channels. The matrix of channels may be referred to as an array, bed, grid or lattice of channels. The matrix of channels may divide the interior of the body to form the first and second chambers. In other words, the matrix may separate the first and second chambers. Each parallel elongate channel may not intersect any of the other parallel elongate channels.

[0014]

[0010] In some embodiments, the inlet is attached to the first portion of channels at a first end of the matrix, and the outlet is attached to the second portion of channels at a second end of the matrix, wherein the first chamber is adjacent the second end of the matrix and the second chamber is adjacent the first end of the matrix. The inlet may be attached to the first portion of channels such that fluid received at the inlet is directed through the first portion of channels, optionally only through the first portion of channels. The outlet may be attached to the second portion of channels such that the outlet receives fluid from the second portion of channels, optionally only from the second portion of channels. The first chamber may be adjacent the second end of the matrix and the second chamber may be adjacent the first end of the matrix such that the inlet is not in direct fluid communication with the second chamber and the outlet is not in direct fluid communication with the first chamber.

[0015]

[0011] In some embodiments, each channel has a constant cross-section perpendicular to its length, optionally a circular, triangular, hexagonal and / or rectangular cross-section. In some embodiments, each channel has a diameter or width that is no more than 50%, no more than 25% or no more than 10% of a diameter or width of the inlet and / or the outlet. The diameter or width of each channel may be 25% of the diameter or width of the inlet and / or the outlet. A diameter or width of the inlet may be equal to a diameter or width of the outlet. A cross-sectional area of the inlet may be equal to a cross-sectional area of the outlet. This can enable improved sound attenuation while reducing flow attenuation (or backpressure) caused by the device. In some embodiments, an axis of the outlet is offset from an axis of the inlet. In some embodiments, the outlet is fluidically coupled to a surrounding atmosphere. In some embodiments, the outlet is shaped to direct fluid received from the inlet via the flow control structure towards the pump. In some embodiments, the flow control structure is configured to attenuate sound emitted by the pump by at least about 10 dB. In some embodiments, the body comprises a length of about 1 / 32 of a standing wave frequency of sound emitted by the pump. In some embodiments, the device has a monolithic structure. The inlet, outlet, body, and flow control structure may be integrally formed. In some embodiments, the device is formed by 3D printing. In some embodiments, the device is made of acrylonitrile butadiene styrene, ABS. In some embodiments, the fluid from the pump comprises one or more exhaust gases output by the pump. In some embodiments, the inlet is fluidically coupled to the pump.

[0016]

[0012] Another aspect of the disclosure provides a fluidic system for collecting a biological sample, optionally earwax, of a subject, the system comprising: a canister configured to fluidically couple to a suction applicator and collect a biological sample, optionally earwax, received from the suction applicator; a pump fluidically coupled to the canister and configured to generate suction through the canister; and any of the sound attenuation devices described herein, wherein the inlet of the device is fluidically coupled to an outlet of the pump. In some embodiments, the outlet of the sound attenuation device is shaped to direct fluid towards a surface of the pump to provide cooling. The fluidic system may further comprise the suction applicator.

[0017]

[0013] Another aspect of the disclosure provides a method for receiving or obtaining a biological sample of a subject, comprising: receiving or obtaining the biological sample of the subject through a lid into a canister vessel, wherein the lid is fluidically coupled to the canister vessel, wherein the lid comprises a first curved body concentric with a second curved body, and wherein the lid is removably coupled to the canister vessel. In some embodiments, the lid, the canister vessel, or a combination thereof are fluidically coupled to a filter. In some embodiments, the filter is disposed in the lid. In some embodiments, the filter is disposed within the first curved body. In some embodiments, the filter is configured to swell when the filter absorbs the biological sample of the subject. In some embodiments, the filter self-seals to the first curved body. In some embodiments, the first curved body concentric with the second curved body provides a flow of a fluid of at least about 14.5 liters per minute between the lid, the filter, the canister vessel, or any combination thereof. In some embodiments, the first curved body concentric with the second curved body provides a laminar flow of a fluid between the lid, the filter, the canister vessel, or any combination thereof. In some embodiments, the filter is covered by a third body. In some embodiments, the biological sample comprises ear wax or a bodily fluid of the subject. In some embodiments, the lid, the canister vessel, or a combination thereof, is fluidically coupled to a vacuum pump. In some embodiments, the canister vessel, the lid, or a combination thereof is fluidically coupled to a valve, wherein the valve is fluidically coupled to the atmosphere. In some embodiments, the valve decreases suction of the vacuum pump when the valve is opened.

[0018]

[0014] Another aspect of the disclosure provides a method for reducing an auditory output of a pump, comprising: providing a pump fluidically coupled to a sound attenuator, wherein the sound attenuator comprises a first half comprising an inlet and a second half comprising an outlet, and wherein a first central axis of the inlet and a second central axis of the outlet are offset by a distance, and wherein a material is disposed within the first half and the second half of the sound attenuator; and reducing an auditory output of the pump when the pump is fluidically coupled to the sound attenuator and is actuated. In some embodiments, the material comprises a polymer fiber, foam, cotton, or any combination thereof. In some embodiments, the outlet is fluidically coupled to the atmosphere. In some embodiments, the first body or the second body is injection molded. In some embodiments, the auditory output of the pump is attenuated by at least about lOdB. In some embodiments, the first body and / or the second body comprise a length of about 1 / 32 of a standing wave frequency of the auditory output of the pump. In some embodiments, the first body and / or the second body are made of acrylonitrile butadiene styrene (ABS). In some embodiments, the first body is ultrasonically welded to the second body.

[0019]

[0015] Another aspect of the disclosure provides a method for coupling a nozzle with a fluidic system interface, comprising: providing the fluidic system interface, wherein the fluidic system interface comprises a track and a nozzle receptacle; translating a rail mechanically coupled to a canister lid along the track of the fluidic system interface; and coupling a nozzle of the canister lid with the fluidic system interface when a first magnet disposed in the nozzle is at a distance from a second magnet disposed in the fluidic system. In some embodiments, the canister lid is configured to receive a biological sample. In some embodiments, the biological sample comprises ear wax or a bodily fluid. In some embodiments, the canister lid comprises a filter. In some embodiments, the filter self-seals in the canister lid. In some embodiments, the filter is configured to swell when the filter absorbs the biological sample of the subject. In some embodiments, the fluidic system interface is coupled to a pump. In some embodiments, the fluidic system interface is fluidically coupled to a valve, wherein the valve is fluidically coupled to the atmosphere. In some embodiments, the valve decreases suction of the pump when the valve is opened.

[0020]

[0016] Another aspect of the disclosure provides a device configured to couple a probe and / or suction applicator to a fluidic system, comprising: a body comprising a first magnet, wherein the body is configured to mechanically couple to a surface of the probe and / or suction applicator, and wherein the first magnet is configured to couple to a second magnet of the fluidic system. In some embodiments, the body comprises a first body and a second body. In some embodiments, the first body and the second body are comprised of an injection molded material. In some embodiments, the probe and / or suction applicator comprises a suction tubing or a suction rigid body. In some embodiments, the body comprises a curved surface configured to couple to the surface of the probe and / or suction applicator. In some embodiments, the body mechanically couples to a surface of the probe and / or suction applicator with an interference fit, snap fit, or a slip fit. In some embodiments, the body comprises a surface, wherein the surface of the body produces a frictional force when the surface of the probe and / or suction applicator is translated over the surface of the body thereby fixing a position of the body on the probe and / or suction applicator. In some embodiments, the second magnet is disposed adjacent a surface of the fluidic system.

[0021]

[0017] Another aspect of the disclosure provides a method for coupling a probe and / or suction applicator to a fluidic system, comprising: suctioning a subject’s ear with the probe and / or suction applicator; and coupling a first magnet of a body mechanically coupled to a surface of the suction to a second magnet of the fluidic system fluidically coupled to the probe and / or suction applicator. In some embodiments, the body comprises a first body and a second body. In some embodiments, the first body and the second body are comprised of an injection molded material. In some embodiments, the probe and / or suction applicator comprises a suction tubing or a suction rigid body. In some embodiments, the body comprises a curved surface configured to couple to the surface of the probe and / or suction applicator. In some embodiments, the body mechanically couples to a surface of the probe and / or suction applicator with an interference fit, snap fit, or a slip fit. In some embodiments, the body comprises a surface, wherein the surface of the body produces a frictional force when the surface of the probe and / or suction applicator is translated over the surface of the body thereby fixing a position of the body on the probe and / or suction applicator. In some embodiments, the second magnet is disposed adjacent a surface of the fluidic system.

[0022] INCORPORATION BY REFERENCE

[0023]

[0018] All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference.

[0024] BRIEF DESCRIPTION OF THE DRAWINGS

[0025]

[0019] The novel features of the present disclosure are set forth with particularity in the appended claims. A better understanding of the features and advantages of the present disclosure will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the present disclosure are utilized, and the accompanying drawings of which:

[0026]

[0020] FIGs. 1A-1B show components of a sound attenuator used in some embodiments of the devices and methods described herein. FIG. 1A shows a transparent perspective view of a sound attenuator. FIG. IB shows a perspective view of the two components of a sound attenuator and a material disposed within the sound attenuator.

[0027]

[0021] FIGs. 1C-1 to 1C-4 show schematic views of other exemplary sound attenuators.

[0028]

[0022] FIGs. ID-1 to ID-7 show views of a further exemplary sound attenuator. FIG. ID-1 shows a perspective view of a sound attenuator, FIG. ID-2 shows a cutaway view of the sound attenuator of FIG. ID-1, and FIGs. ID-3 to ID-6 show cross-sectional views o the sound attenuator of FIG. ID-1. FIG. ID-7 shows a schematic view of the attenuator of FIG. ID-1 and a pump.

[0029]

[0023] FIGs. 2A-2C show components of the track and magnet canister guide feature. FIG. 2A shows an exterior front view of a track and magnet canister guide feature. FIG. 2B shows a front view of a canister inside the track and magnet guide feature. FIG. 2C shows a cross-sectional view of the track and magnet canister guide feature.

[0030]

[0024] FIGs. 3A-3C show a holding collar coupled to an exterior surface of the fluidic system. FIG. 3A shows a cross-sectional view of the holding collar coupled to the surface of the fluidic system. FIG. 3B shows a perspective view of a suction tube coupled to the holding collar. FIG. 3C shows an exterior perspective view of a suction tube coupled to the holding collar where the holding collar and the suction tube are coupled to the surface of the fluidic system.

[0031]

[0025] FIG. 4 shows a side cross-sectional view and fluid flow diagram of the fluidic system.

[0032]

[0026] FIG. 5 shows a fluid flow schematic between the different components of the fluidic system.

[0033]

[0027] FIG. 6 shows a perspective view of the fluidic system with a suction tube and canister.

[0034]

[0028] FIG. 7 shows a perspective view of the probe and / or suction applicator provided within an otoscope system.

[0035]

[0029] FIG. 8 shows a perspective view of a probe and / or suction applicator coupled to a fluidic system, where the probe and / or suction applicator is inserted into an ear phantom.

[0036]

[0030] FIGs. 9A-9C show sketches of the canister lid. FIG. 9A shows a side cross-sectional view of the canister lid. FIG. 9B shows a bottom view of the canister lid. FIG. 9C shows a side perspective view of the canister lid.

[0037]

[0031] FIGs. 10A-10D show rendered perspective views of the canister lid. FIG. 10A shows a front perspective view of the canister lid. FIG. 10B shows a bottom perspective view of the canister lid. FIG. 10C shows a back perspective view of the canister lid. FIG. 10D shows a side perspective view of the canister lid.

[0038]

[0032] FIG. 11 shows an exploded view of the canister lid.

[0039]

[0033] FIGs. 12A-12D show illustrations of the canister lid. FIG. 12A shows a front perspective view of the canister lid. FIG. 12B shows a bottom perspective view of the canister lid. FIG. 12C shows a back perspective view of the canister lid. FIG. 12D shows a top perspective view of the canister lid.

[0040]

[0034] FIG. 13 shows a rendered bottom perspective view of an assembled canister lid.

[0041] DETAILED DESCRIPTION

[0042]

[0035] Provided herein are devices, methods, and systems for removal of bodily fluids and / or biological sample of a subject, for testing, diagnostics, and / or other purposes. The device described herein may safely and effectively remove earwax from a subject’s ear in an automated manner. The device described herein may remove other bodily fluids and / or a biological sample from other body parts of a subject. The device described herein may also test earwax, bodily fluids and / or other biological samples removed from a subject’s ear using an electronic device in order to provide diagnostic or medical information pertaining to the subject.

[0043]

[0036] The ear canal comprises glands that produce a waxy oil called cerumen, also known as earwax. This wax will frequently make its way to the outside of the ear, where it may fall out or may be removed by washing. However, in some cases, wax can build up and block the ear canal. Earwax buildup is the most common cause of hearing loss. Earwax buildup can also cause other symptoms, including earache, a fullness in the ear or a sense that the ear is plugged, dizziness, and / or noises in the ear (e.g., tinnitus).

[0044]

[0037] Current methods for removing excess earwax include solutions that dissolve earwax, ear irrigation, or in-office earwax removal. Some cerumenolytic solutions (e.g., solutions to dissolve wax), such as saline solution, baby oil, glycerin, mineral oil, or hydrogen peroxide / peroxide- based ear drops can be used to remove ear wax. With these cerumenolytic solutions, a user can put a few drops of the solution in the affected ear and lie on their opposite side to allow for the solution to degrade, dissolve, dislodge and / or detach the ear wax to be removed. Such oils can be used over the counter by an affected user.

[0045]

[0038] Another over the counter method of removing ear wax is ear irrigation. This involves a user using a syringe to rinse out their ear with water or saline solution. Frequently, a user will first use a cerumenolytic solution to dissolve the ear wax, followed by irrigation.

[0046]

[0039] Such over-the-counter solutions can be ineffective or even risky when performed at home by a user. Another solution is in-office earwax removal by a healthcare provider. A provider can remove earwax manually using instruments such as a cerumen spoon, forceps, irrigation, or a suction device.

[0047]

[0040] The present disclosure provides devices, systems, and methods that may solve some of the problems of other earwax removal methods. Notably, the present disclosure provides a device that can remove earwax of a subject in a safe and effective manner by a healthcare provider at a point-of-care location, without requiring an in-office visit. The systems and devices described herein may also use automated, non-manual methods to remove earwax, which may increase effectiveness and ease of earwax removal compared to manual methods.

[0048]

[0041] The present disclosure provides a device for receiving a biological sample of a subject, comprising: (a) a lid at least partially covering a first curved body concentric with a second curved body; and (b) a canister vessel removably coupled to the lid, wherein the lid is fluidically coupled to the canister vessel, and wherein the canister vessel is configured to receive the biological sample of the subject. In some cases, the device may comprise a filter fluidically coupled to the lid, the canister vessel, or a combination thereof. In some cases, the filter may be disposed in the lid. In some cases, the filter may be disposed within the first curved body. In some cases, the filter may be configured to swell when the filter absorbs the biological sample of the subject. In some cases, the filter may self-seal to the first curved body. In some cases, the first curved body concentric with the second curved body may provide a flow of a fluid of at least about 14.5 liters per minute between the lid, the filter, the canister vessel, or any combination thereof. In some cases, the first curved body concentric with the second curved body may provide a laminar flow of fluid between the lid, the filter, the canister vessel, or a combination thereof. In some cases, the filter may be covered by a third body. In some cases, the biological sample may comprise earwax and / or a bodily fluid of the subject. In some cases, the canister vessel and / or lid may be fluidically coupled to a pump. In some cases, the pump may comprise a pump of a fluidic system, described elsewhere herein. In some cases, the canister vessel and / or lid may be fluidically coupled to a valve, wherein the valve may be fluidically coupled to the atmosphere. In some cases, the valve may decrease suction of the pump when the valve is opened.

[0049]

[0042] The present disclosure provides a device for attenuating sound, comprising: (a) a first body comprising an inlet coupled to an output of a pump; (b) a second body comprising an outlet, wherein the second body is coupled to the first body, and wherein an axis of the outlet is offset from an axis of the inlet; and (c) a material disposed within the first body and the second body configured to attenuate a sound of the pump. In some cases, the pump may comprise a pump of a fluidic system. In some cases, the material may comprise a polymer fiber, foam, cotton, or any combination thereof. In some cases, the outlet may be fluidically coupled to the atmosphere. In some embodiments, the first body and / or the second body may be injection molded. In some embodiments, the sound of the pump may be attenuated by at least about lOdB. In some embodiments, the first body or the second body may comprise a length of about 1 / 32 of a standing wave frequency of the sound of the pump. In some embodiments, the first body or the second body may be made of acrylonitrile butadiene styrene (ABS). In some embodiments, the first body may be ultrasonically welded to the second body.

[0043] The present disclosure provides a system for receiving a biological sample of a subject, comprising: (a) a fluidic system interface comprising a track and a nozzle receptacle; and (b) a lid comprising a nozzle and a rail, wherein the lid is configured to be removably coupled to a canister vessel, wherein the rail of the lid is configured to mechanically couple to the track, wherein the nozzle is configured to couple to the nozzle receptacle when a first magnet of the lid is at a distance from a second magnet disposed in the fluidic system, and wherein the canister vessel is configured to receive the biological sample of the subject. In some embodiments, the biological sample comprise earwax and / or a bodily fluid of the subject. In some embodiments, the lid may comprise a filter. In some embodiments, the filter may self-seal in the lid. In some embodiments, the filter is configured to swell when the filter absorbs the biological sample of the subject. In some embodiments, the fluidic system interface is coupled to a pump. In some embodiments, the fluidic system interface is fluidically coupled to a valve, wherein the valve is fluidically coupled to the atmosphere. In some embodiments, the valve decreases suction of the pump when the valve is opened.

[0050]

[0044] The present disclosure provides a method for receiving or obtaining a biological sample of a subject, the method comprising: receiving or obtaining the biological sample of the subject through a lid into a canister vessel, wherein the lid is fluidically coupled to the canister vessel, wherein the lid comprises a first curved body concentric with a second curved body, and wherein the lid is removably coupled to the canister vessel. In some cases, the lid, the canister vessel, or a combination thereof may be fluidically coupled to a filter. In some cases, the filter may be disposed in the lid. In some cases, the filter may be disposed within the first curved body. In some cases, the filter may be configured to swell when the filter absorbs the biological sample of the subject. In some cases, the filter may self-seal to the first curved body. In some cases, the first curved body concentric with the second curved body may provide a flow of a fluid of at least about 14.5 liters per minute between the lid, the filter, the canister vessel, or any combination thereof. In some cases, the first curved body concentric with the second curved body may provide a laminar flow of a fluid between the lid, the filter, the canister vessel, or any combination thereof. In some cases, the filter may be covered by a third body. In some cases, the biological sample may comprise earwax and / or a bodily fluid of the subject. In some cases, the canister vessel, canister lid, or any combination thereof may be fluidically coupled to a vacuum pump. In some cases, the canister vessel, canister lid, or any combination thereof may be fluidically coupled to a valve, wherein the valve may be fluidically coupled to the atmosphere. In some cases, the valve may decrease suction of the vacuum pump when the valve is opened.

[0051]

[0045] The present disclosure provides a method for reducing an auditory output of a pump, the method comprising: (a) providing a pump fluidically coupled to a sound attenuator, wherein the sound attenuator comprises a first half comprising an inlet and a second half comprising an outlet, and wherein a first central axis of the inlet and a second central axis of the outlet are offset by a distance, and wherein a material is disposed within the first half and the second half of the sound attenuator; and (b) reducing an auditory output of the pump when the pump is fluidically coupled to the sound attenuator and is actuated. In some cases, the material disposed within the first half and the second half of the sound attenuator may comprise a polymer fiber, foam, cotton, or any combination thereof. In some cases, the outlet may be fluidically coupled to the atmosphere. In some cases, the first body and / or the second body may be injection molded. In some cases, the auditory output of the pump may be attenuated by at least about lOdB when the pump is fluidically coupled to the sound attenuator and is actuated. In some cases, the first body and / or the second body may comprise a length of about 1 / 32 of a standing wave frequency of the auditory output of the pump. In some cases, the first body and / or the second body may be made of acrylonitrile butadiene styrene (ABS). In some cases, the first body may be ultrasonically welded to the second body.

[0052]

[0046] The present disclosure provides a method for coupling a nozzle with a fluidic system interface, the method comprising: providing the fluidic system interface, wherein the fluidic system interface comprises a track and a nozzle receptacle; translating a rail mechanically coupled to a canister lid along the track of the fluidic system interface; and coupling a nozzle of the canister lid with the fluidic system interface when a first magnet disposed in the nozzle is at a distance from a second magnet disposed in the fluidic system. In some cases, the canister lid may be configured to receive a biological sample. In some cases, the biological sample may comprise earwax and / or a bodily fluid. In some cases, the canister lid may comprise a filter. In some cases, the filter may self-seal in the canister lid. In some cases, the filter may be configured to swell when the filter absorbs the biological sample of the subject. In some cases, the fluidic system interface may be coupled to a pump. In some cases, the fluidic system interface may be fluidically coupled to a valve, wherein the valve may be fluidically coupled to the atmosphere. In some cases, the valve may decrease suction of the pump when the valve is opened.

[0047] The present disclosure provides a device configured to couple a probe and / or suction applicator to a fluidic system, comprising: a body comprising a first magnet, wherein the body is configured to mechanically couple to a surface of the probe and / or suction applicator, and wherein the first magnet is configured to couple to a second magnet of the fluidic system. In some cases, the body may comprise a first body and a second body. In some cases, the first body and the second body may be comprised of an injection molded material. In some cases, the probe and / or suction applicator may comprise a suction tubing or a suction rigid body. In some cases, the body may comprise a curved surface configured to couple to the surface of the probe and / or suction applicator. In some cases, the body may mechanically couple to a surface of the probe and / or suction applicator with an interference fit, snap fit, or a slip fit. In some cases, the body may comprise a surface, wherein the surface of the body may produce a frictional force when the surface of the probe and / or suction applicator is translated over the surface of the body thereby fixing a position of the body on the probe and / or suction applicator. In some cases, the second magnet may be disposed adjacent a surface of the fluidic system.

[0053]

[0048] The present disclosure provides a method for coupling a probe and / or suction applicator to a fluidic system, the method comprising: suctioning a subject’s ear with the probe and / or suction applicator; and coupling a first magnet of a body mechanically coupled to a surface of the probe and / or suction applicator to a second magnet of the fluidic system fluidically coupled to the probe and / or suction applicator. In some cases, the body may comprise a first body and a second body. In some cases, the first body and the second body may be comprised of an injection molded material. In some cases, the probe and / or suction applicator may comprise a suction tubing and / or a suction rigid body. In some cases, the body may comprise a curved surface configured to couple to the surface of the probe and / or suction applicator. In some cases, the body may mechanically couple to a surface of the probe and / or suction applicator with an interference fit, snap fit, or a slip fit. In some cases, the body may comprise a surface, wherein the surface of the body may produce a frictional force when the surface of the probe and / or suction applicator is translated over the surface of the body thereby fixing a position of the body on the probe and / or suction applicator. In some cases, the second magnet may be disposed adjacent a surface of the fluidic system.

[0054]

[0049] The figures described herein show various embodiments of the systems, devices, and / or methods described herein. FIGs. 1A to ID-7 show various examples of sound attenuators configured to reduce an output sound of a pump of a fluidic system when the pump of the fluidic system is actuated. In other words, the sound attenuators may attenuate an output sound intensity of the fluidic system. In general, the sound attenuators disclosed herein each include an inlet for receiving a fluid flow (e.g. exhaust gases) from the pump, a flow control structure between the inlet and the outlet configured to dampen or otherwise attenuate sound emitted by the pump (in the fluid flow), and an outlet. Generally, the flow control structure splits the received fluid flow into a plurality of different flow paths having a tortuous shape (e.g. a meandering, curved, twisting, winding, sigmoidal, sinusoidal, serpentine, S-shaped and / or U-shaped path). This causes the fluid flow to be split and directed along relatively long, twisting paths (relative to the size of the attenuator), causing sound energy in the fluid flow to be dissipated efficiently. The attenuators described herein may be configured to attenuate sound emitted by a pump by at least about 10 dB when coupled to the pump and when the pump is running.

[0055]

[0050] FIGs. 1A-1B show a first example sound attenuator 100. FIG. 1A shows a transparent perspective view of the sound attenuator 100 that may reduce an output sound of a pump of a fluidic system when the pump of the fluidic system is actuated. The sound attenuator 100 may attenuate an output sound intensity of the fluidic system. The sound attenuator 100 may comprise a first body 103 and a second body 101. The sound attenuator may comprise a first channel 104a and a second channel 104b, each of which could be either an inlet or outlet. The first channel 104a and the second channel 104b can be disposed in parallel with one another. In some cases, the first channel 104a and the second channel 104b may be separated by a distance 105. In some cases, the distance may comprise a distance between a first central axis 107a of the first channel 104a and a second central axis 107b of the second channel 104b. The sound attenuator 100 can have a length 106. In some cases, the length 106 of the sound attenuator 100 may comprise a distance of a fraction of one or more wavelength(s) of an output sound of the pump of the fluidic system that the sound attenuator is fluidically coupled to. For example, the length 106 may comprise about 1 / 32 the length of the one or more wavelength(s) of the output sound of the pump of the fluidic system. In some instances, the output sound of the pump may comprise a standing wave output sound.

[0056]

[0051] FIG. IB shows a perspective view of the two halves of the sound attenuator with a polyester material fill. The sound attenuator may comprise a first body 103 and a second body 101. The two bodies of the sound attenuator may be injection molded. The sound attenuator may comprise a material 102 disposed within the first body 103 and / or the second body 101, e.g. within a chamber defined by the first body 103 and / or the second body 101. For example, the material may comprise polyester. In some cases, the first body and / or the second body may be made of acrylonitrile butadiene styrene (ABS). The material may comprise polymer fiber, foam, cotton, or any combination thereof. The sound attenuator material may absorb sound, thereby attenuating it. The sound attenuator may comprise an inlet or outlet (104a, 104b). The offset between the inlet and outlet (104a, 104b), as shown in FIG. 1A, can guide sound to propagate through the sound attenuator material, dampening an intensity of the sound. The sound attenuator may be placed on the output of the pump to dampen the sound outputted by the pump. This may provide a more pleasant experience for a subject when the fluidic system is used to remove a biological sample of the subject, as the fluidic system may not be as loud as it otherwise might be without the sound attenuator.

[0057]

[0052] FIGs. 1C-1 to 1C-4 show other example sound attenuator devices 120. Similarly to the sound attenuator 100 shown in FIGs. 1A and IB, the sound attenuators 120 include a first channel 124a and a second channel 124b, each of which could be either an inlet or outlet. The first channel 124a and the second channel 124b can be disposed in parallel with one another. In some cases, as shown in FIGs. 1C-1 to 1C-3, the first channel 124a and the second channel 124b may be separated by a distance (e.g. a distance between the central axes of the channels).

[0058]

[0053] In contrast to the sound attenuator 100 shown in FIGs. 1A-1B, the sound attenuators 120 of FIGs. 1C-1 to 1C-4 are formed of a single body 121 and each have a flow control structure 122 that includes a plurality of elongate channels 123. The flow control structure 122 is disposed within an interior of the body 121, such that a space or chamber (130a, 130b) is provided at each end of the flow control structure 122. As described below, the flow control structure 122 and the chambers 130a, 130b are arranged such that a fluid flow received at an inlet (e.g. inlet 124a) is directed towards the outlet (e.g. outlet 124b) along flow paths 128 that pass from one end of the channels 123 and the flow control structure 122 to another at least twice. Accordingly, the flow paths 128 can have an S-shaped, U-shaped, meandering, winding, or otherwise twisted shape.

[0059]

[0054] The sound attenuators 120 can have a length 126, which may be a length of the whole attenuator body 121, or a length of part of the attenuator, such as a distance between ends of the flow control structure 122, a length of the elongate channels 123, or a length over which the flow paths pass back and forth. In some cases, the length 126 of the sound attenuator 120 may comprise a distance of a fraction of one or more wavelength(s) of an output sound of the pump of the fluidic system that the sound attenuator is configured to fluidically couple to. For example, the length 126 may comprise about 1 / 32 the length of the one or more wavelength(s) of the output sound of the pump of the fluidic system. In some instances, the output sound of the pump may comprise a standing wave output sound.

[0060]

[0055] As shown, the flow control structure 122 is formed as a matrix of parallel (nonintersecting), elongate channels 123 each having a width or diameter Dcthat is smaller than a diameter Di of the inlet (124a). For example, the diameters Dcmay be selected to partially inhibit the fluid flow through the attenuator. The channel diameters Dcare also typically smaller than a diameter Doof the outlet (124b). The channel diameters Dcmay be no more than around 50%, no more than around 25%, or no more than around 10% of the inlet diameter Di and / or the outlet diameter Do. In attenuators 120 for fluidic systems for collecting a biological sample from a subject (such as earwax), the channel diameters Dcmay be no more than around 5 mm, no more than around 1 mm, or no more than around 0.5 mm, and / or the channel diameters Dcmay be no less than around 10 microns, no less than around 50 microns, no less than around 100 microns, or no less than around 500 microns. As shown, in these examples the inlet diameter Di is approximately equal to the outlet diameter Do, which can reduce flow rate attenuation or backpressure caused by the sound attenuator 120. Those skilled in the art will appreciate that any other diameter sizes may be used, depending on the application and type of pump that the attenuator is to be used with. As used herein, the term “diameter” refers to a width or dimension transverse to a fluid flow, and channels, inlets or outlets having a “diameter” may have any cross-sectional shape, such as circular, triangular, hexagonal, rectangular, or any combination thereof.

[0061]

[0056] The channels 123 are open at each end. Accordingly, as the fluid flow received at the inlet flows through the attenuator 120 and towards the outlet, the flow is divided between a plurality of the channels and directed along a bending (e.g. S-shaped) path 128. In other words, fluid flow within the attenuator 120 (from an inlet to an outlet) changes direction multiple times and diverges and converges multiple times. This causes the attenuator 120 to absorb sound, thereby attenuating the sound. As shown in FIGs. 1C-1 to 1C-3, an offset between the inlet and outlet (124a, 124b), can guide sound to propagate through the device (via the channels 123 of the flow control structure 122), dampening an intensity of the sound. The sound attenuator may be placed on the output of the pump to dampen the sound outputted by the pump. This may provide a more pleasant experience for a subject when the fluidic system is used to remove a biological sample of the subject (such as earwax), as the fluidic system may not be as loud as it otherwise might be without the sound attenuator.

[0062]

[0057] In the example attenuator device 120 shown in FIG. 1C-1, channels or conduits of the inlet and the outlet (124a, 124b) are each attached to separate groups of the (small) channels of the flow control structure 122. In particular, the inlet is attached to a first portion of the channels 123 such that fluid flow received at the inlet is directed into the first portion of channels, and the outlet is attached to a second portion of the channels 123 such that the outlet (only) receives fluid flow from the second portion of channels. A third separate portion of the channels 123 is attached to neither the inlet nor the outlet directly. In this example, a chamber 130a is fluidically coupled to the inlet via the first portion of channels that are attached to the inlet. Another chamber 130b is fluidically coupled to the outlet via the second portion of channels that are attached to the outlet. The chambers 130a, 130b are fluidically coupled to each other via the third portion of channels. Accordingly, multiple flow paths 128 exist from the inlet to the outlet via: the first portion of channels 123, the chamber 130a, the third portion of channels 123, the chamber 130b, and the second portion of channels 123. Thus, the flow paths 128 in this example are generally sigmoidal or S-shaped, and one such flow path 128 is shown using dashed lines in FIG. 1C-1. The flow paths 128 pass between one end of the channels 123 (the end nearest the inlet) and another end of the channels 123 (the end nearest the outlet) at least three times. The skilled person will appreciate that there may be some circulation of fluid within the attenuator, e.g. within each chamber 130a, 130b or between the chambers via two or more of the third portion of channels 123 - this absorbs additional sound energy from the flow and further improves the sound attenuation performance.

[0063]

[0058] Other example attenuators 120 are shown in FIGs. 1C-2 to 1C-4. In FIG. 1C-2, the inlet and outlet are not directly attached to channels of the flow control structure 122, but instead the inlet directs fluid into a first chamber 130a and the outlet receives fluid from a second chamber 130b. Accordingly, fluid flows from the inlet, into the chamber 130a, through one or more of the channels 123 of the flow control structure, into the chamber 130b, and then into the outlet. In this example, the flow paths 128 pass through the flow control structure 122 at least once. Similarly to FIG. 1C-1, the flow paths 128 in this example are also sigmoidal and pass between one end of the elongate channels (nearest the inlet) and the other end of the elongate channels (nearest the outlet) at least three times. Unlike the example of FIG. 1C-1, the flow paths 128 in FIG. 1C-2 pass from the inlet at a first end of the elongate channels 123 to a second end of the elongate channels (nearest the outlet) without passing through any of the channels of the flow control structure. The flow paths pass from the second end of the channels to the first end through the channels 123. They then pass from the first end back to towards the second end (nearest the outlet) without passing through the channels 123.

[0064]

[0059] In FIG. 1C-3, the flow control structure 122 is arranged within the body 121 such that the flow paths 128 from the inlet to the outlet pass between the ends of the elongate channels 123 at least four times - in other words, the flow paths include more than one sigmoidal portion (e.g. three turns as shown). Specifically, the inlet and outlet are located on the same side of the attenuator and a partition 132 within the body is used to define three chambers 130a-c, such that flow paths 128 from the inlet to the outlet pass through the flow control structure 122 at least four times.

[0065]

[0060] In FIG. 1C-4, the inlet 124a and the outlet 124b are positioned without an offset, such that their central axes (not shown) are aligned. Again, the flow control structure 122 is arranged within the body 121 such that three chambers 130a-c are defined therein (in this case using a partition 132) and such that the flow paths 128 from the inlet to the outlet pass between the ends of the elongate channels 123 at least twice (and through the flow control structure 122 at least twice). Specifically, the flow path 128 shown in this example passes from a first end of the channels 123 (the end nearest chambers 130a, 130c), to a second end of the channels (nearest chamber 130b) and back to the first end. In this example, the elongate channels 123 of the flow control structure are oriented perpendicularly to the axes of the inlet and outlet, but other orientations may be used. Although the flow paths shown in the examples of FIGs. 1C-1 to 1C-4 are curved, those skilled in the art will appreciate that the paths may have similar shapes but formed of linear sections.

[0066]

[0061] FIGs. ID-1 to ID-7 show an example sound attenuator device 140. The attenuator 140 is an example implementation of the attenuator 120 shown in FIG. 1C-1. As shown in the perspective view of FIG. ID-1, the attenuator 140 includes a body 141, an inlet 144a and an outlet 144b. The inlet is configured to couple to a pump of a fluidic system to receive a fluid flow (e.g. exhaust gas such as air) from the pump. In this example, the outlet 144b is configured for outputting the received fluid flow to a surrounding atmosphere, but in other examples the outlet of the attenuator may connect to further components of the fluidic system. As shown, the body 141 may include additional features such as attachment points for securing the attenuator, e.g. within a fluidic system.

[0067]

[0062] As shown in the cutaway view of FIG. ID-2 and the corresponding cross-sectional view of FIG. ID-3, the attenuator 140 includes a flow control structure 142 within an interior of the body 141. The flow control structure 142 may correspond to the flow control structures 122 described above, and is formed of a matrix or bed of elongate, parallel channels 143. As shown in FIG. ID-2, these channels 143 are hexagonal, and have a constant cross-section (in the direction perpendicular to their length - as shown in FIGs. ID-4 and ID-5). As shown, the inlet 144a and the outlet 144b are offset and connect directly to different portions or regions of the matrix of channels 143, and at each end of the matrix there is a chamber 150a, 150b. Thus, multiple flow paths (corresponding to the flow paths 128 described above with respect to FIG. 1C-1) are provided between the inlet 144a and the outlet 144b.

[0068]

[0063] The body 141 of the attenuator 140 has a generally monolithic construction. In other words, the components of the attenuator 140 (including the inlet, outlet, body and flow control structure) are integrally formed as a single unit. Accordingly, the attenuator 140 can be formed using additive manufacturing processes, such as 3D-printing. For example, the attenuator 140 may be 3D-printed using a material comprising metal and / or plastic, such as a material comprising one or more of: acrylonitrile butadiene styrene (ABS), polylactic acid (PLA), polyethylene terephthalate glycol (PETG), polycarbonate (PC), nylon 6 (PA6), acrylonitrile styrene acrylate (ASA), a thermoplastic polyurethane (TPU), or any fiber-reinforced versions thereof. However, those skilled in the art will appreciate that the attenuator 140 may be formed of any suitable material. In the example shown in FIGs. ID-1 to ID-7, the construction of the flow control structure 142 has a generally extruded form with a constant cross-section in at least one direction, is well-adapted for additive manufacture such as 3D-printing. This can also enable reliable and repeatable attenuation performance. By selecting dimensions and other parameters of the flow control structure 142, the sound attenuation performance can also be controlled or adjusted reliably.

[0069]

[0064] FIG. ID-4 shows a cross-sectional view of the attenuator 140 from one end of the matrix of channels (along the section line A-A shown in FIG. ID-3) and FIG. ID-5 shows a cross- sectional view of the attenuator 140 from another end of the matrix (along the section line B-B shown in FIG. ID-3). As shown, the inlet 144a is connected to and directs fluid flow into 12 of the channels 143 of the flow control structure 142. The remaining channels 143 are open to (adjacent) the chamber 150b at one end (an end of the matrix of channels that is closest to the inlet 144a). Similarly, the outlet 144b is connected to and receives fluid flow from 19 of the channels 143, which are different from the 12 channels connected to the inlet. The channels 143 other than those connected to the outlet 144b are open to (adjacent) the chamber 150a at an end (an end of the matrix of channels that is closest to the outlet 144b). As shown, many of the channels 143 that are connected to neither the inlet nor the outlet are open to both chambers 150a, 150b at their respective ends. In some examples, the dimensions of the inlet 144a and the outlet 144b (e.g. diameters or widths Di, Do) are selected such that the cross-sectional areas of the inlet 144a and the outlet 144b are equal. This can prevent or reduce flow attenuation or pressure loss caused by the sound attenuator 140, which can avoid increasing the load on fluidic system (e.g. a pump) to which the attenuator is coupled. As shown in FIGs. ID-4 and ID-5, the channels 143 have a hexagonal cross-section, and the diameter or width Dcof each channel is defined as the distance between internal parallel faces. In one implementation, the channel width Dcmay be around 25% of the inlet diameter Di (e.g. a Dcof around 1.5 mm and a Di of around 6 mm), which the inventors have found can maximize sound attenuation while minimizing backpressure loss caused by the attenuator 140. Other relative sizes of channel diameter and inlet diameter also provide improved sound attenuation and reduced pressure losses.

[0070]

[0065] The outlet 144b is fluidically coupled to a surrounding atmosphere, such as an atmosphere surrounding a fluidic system with which the attenuator is being used, or an atmosphere surrounding the attenuator but which is internal to a fluidic system (e.g. within a casing or housing of a fluidic system). FIG. ID-6 shows another cross-sectional view of the attenuator 140 along the section line C-C shown in FIG. ID-4. As shown, the outlet 144b has a curved or bent shape that redirects the fluid flow. This can allow the fluid flow exiting the attenuator 140 to be used for cooling one or more components of the fluidic system, such as the pump. Specifically, the outlet 144b shown in FIG. ID-6 includes a conduit that redirects fluid flow back over the top (as shown in these figures) of the attenuator 140, which causes the fluid flowing through the outlet to be directed (downwardly) back towards the inlet 144a (not shown in FIG. ID-6). This can allow the fluid flow (whose sound has been attenuated) to be directed back towards the component (e.g. pump) that produced the sound in the fluid flow. This can provide a cooling effect, which can allow the component to operate more efficiently. A schematic view of a fluidic system comprising the attenuator 140 installed with a pump 405 is shown in FIG ID-7, both of which may be contained within a housing of the fluidic system. In this example, the inlet 144a receives fluid flow (e.g. exhaust) from an output of the pump, which carries sound generated by the pump 405. The fluid flow passes through the attenuator 140, causing the sound to be attenuated, and the fluid is directed by the outlet 144b (as indicated by the white arrow) back over one or more surfaces of the pump 405. The shape of the outlet 144b and / or the relative positioning of the attenuator 140 and the pump 405 can be adjusted to further control which part(s) of the pump are cooled.

[0071]

[0066] FIG. 2A shows a front view of the track 203 and nozzle receptacle 207 of the fluidic system 308 that may receive and / or couple the rail 205 and / or the nozzle 1001 of the lid 201 within and / or to the fluidic system interface. The lid 201 may be coupled to the fluidic system using magnets. The fluidic system may comprise a track 203, bellows 204 the canister may couple to, and a receptacle 207, which can interface with the lid 201 to form a seal with the bellows 204.

[0072]

[0067] FIG. 2B shows a lid 201 and a canister vessel 202 coupled to the fluidic system through a track 203 and nozzle receptacle 207 of the fluidic system 308. The canister vessel 202 may have a capacity of up to about 200 mL. The lid 201 may comprise a rail 205 configured to translate along, in, and / or through a track 203 of the fluidic system. The lid 201 may comprise one more nozzle(s) (206, 1001). In some cases, a first nozzle 206 of one or more nozzles (206, 1001) may be disposed at a first end of the lid and a second nozzle 1001 of one or more nozzles (206, 1001) may be disposed at a second end of the lid. In some cases, the first nozzle 206 and the second nozzle 1001 may be disposed at a distance from one another of a diameter of the lid.

[0073]

[0068] FIG. 2C shows a cross-sectional view of the canister vessel 202 and lid 201 coupled to the fluidic system 308. In some cases, the lid 201 coupled to the canister vessel 202 may be inserted and / or coupled to the fluidic system 308 by translating a rail 205 of the lid 201 along a track 203 of the fluidic system 308. In some cases, the lid 201 and the canister vessel 202 may fluidically couple to the fluidic system 308 when a first magnet 210 of the lid 201 is within a distance from a second magnet 211 of the fluidic system 308. In some cases, the lid 201 and the canister vessel 202 may fluidically couple to the fluidic system 308 when a first magnet of the lid 210 couples to the second magnet 211 of the fluidic system 308. In some cases, a nozzle 1001 of the lid 201 may couple to a bellows 204 of the fluidic system 308. In some cases, the nozzle 1001 of the lid 201 may fluidically couple the lid 201 and / or canister vessel 202 to the fluidic system 308 when a surface of the nozzle 1001 contacts a surface of the bellows 204. The lid 201 may comprise a cover 1101. The lid 201 may comprise a filter 209, which can prevent water, earwax, etc., from entering into a pump of the fluidic system 308. In some cases, the filter 209 may comprise a porous filter. In some cases, the filter 209 may comprise a plastic filter. FIGs. 9A-9C show drawing schematics of the canister lid 201. FIG. 9A shows a side cross-sectional view of the canister lid 201. FIG. 9B shows a bottom perspective view sketch of the canister lid 201. FIG. 9C shows a side cross-sectional view of the canister lid 201. FIG. 10A shows a front view perspective of the canister lid 201. FIG. 10B shows an underside view of the canister lid 201. FIG. 10C shows a back view of the canister lid 201. FIG. 10D shows a side cross-sectional view of the canister lid 201. FIG. 12A shows a perspective view of the front of the canister lid 201. FIG. 12B shows a bottom perspective view of the underside of the canister lid 201. The canister lid 201 may comprise concentric curved bodies 1201 that create laminar flow between the lid and canister vessel. The canister lid 201 may comprise a support feature (e.g., crossshaped features) 1202 to support the filter when it becomes partially or completely wet, selfseals, and / or needs to withstand the full force of the suction pressure of the pump when is the pump is actuated and / or is on and running. FIG. 12C shows a perspective view of the back of the canister lid 201 where it attaches to the fluidic system and / or a pump of the fluidic system. FIG. 12D shows a top perspective view of the canister lid 201. FIG. 13 shows an illustration of the subassembly of the canister lid 201.

[0074]

[0069] The track and nozzle receptacle may comprise magnets 210, which secure the canister (201, 202) within the fluidic system. When the pump is on and obstructed at the probe and / or suction applicator, pressure may drop within the canister, drawing the canister further into the fluidic system compressing a front housing bellows 204 of the fluidic system along an axis concentric with the one or more nozzles (206, 1001). The bellows 204 may comprise a silicon portion that sits between the front housing and the canister (201, 202). The bellows 204 may be designed to conform to the shape of and create an airtight seal with both the front housing and canister when operating the fluidic system. To counter the compression, the magnets (210, 211) may be placed vertically within the lid 201 and fluidic system 308, respectively, thereby holding the lid and canister inside the fluidic system. When the pump of the fluidic system is turned on, the fluidic system may in some cases experience a blockage and vacuum pressure may increase. This increase in vacuum pressure may increase the pulling force between the bellows 204 and the canister lid 201. This may allow for easier packaging and a less sensitive magnetic interface. Horizontally arranged magnets may not work well over this compression travel, so magnets may be arranged vertically to make the system less sensitive to this bellows compression travel. Vertically-arranged magnets may allow for the canister lid 201 to continue traveling toward the bellows 204, further compressing the bellows 204 until the canister lid 201 can no longer move further into the front housing. This additional bellows compression may allow for a stronger seal with the canister that is less likely to fail under vacuum pressure. Horizontally-arranged magnets may not be optimal for this system because of the relatively long distance over which the bellows 204 can compress. Creating a meaningful pulling force over such a long distance may require very large or strong magnets which may be difficult to incorporate into the fluidic system. Vertically-oriented magnets may be used to solely create a pulling force to start the bellows compression / seal, and further to not impede the travel of the canister / bellows under additional vacuum pressure.

[0075]

[0070] FIG. 3A shows a cross-sectional view of the fluidic system and a coupling system that can hold a suction hose 306 against the fluidic system using magnets. The coupling system may comprise a collar 301, comprising two silicon halves. The collar 301 may comprise a magnet 302 located within the collar, which may couple with a magnet 303 inside the housing of the fluidic system. The collar may comprise a curved surface 305. The coupling system may comprise an object used for internal cable strain relief 309. The coupling system may be useful for maintaining cleanliness of a probe and / or suction applicator between uses of the probe and / or suction application by holding the adapter 304 coupled to the suction hose 306 and the probe and / or suction applicator 307 away from other surfaces or objects while in use.

[0076]

[0071] FIG. 3B shows a perspective view of the adapter 304 that is coupled to the suction hose 306 and the probe and / or suction applicator 307, shown here uncoupled to the probe and / or suction applicator 307. The suction hose 306 may be coupled the collar 301, comprised of two silicon halves. The suction hose 306 may be coupled to an adapter 304 that couples to a probe and / or suction applicator 307 that may be inserted into the subject’s ear.

[0072] FIG. 3C shows a perspective view of the suction hose 306 magnetically attached to the outside of the fluidic system 308. The suction hose 306 may be placed inside the collar 301. The suction hose 306 may be connected to an adapter 304, which may couple the suction hose to a probe and / or suction applicator 307 that may be used to test remove and / or extract a bodily fluid and / or biological sample of a subject’s ear. The probe may be inserted into the subject’s ear or other body part of the subject. The fluidic system may comprise a fluidic system interface 602, e.g., buttons controlling on / off power and suction pressure of the fluidic system.

[0077]

[0073] FIG. 4 shows a cross-sectional view and operation diagram of the fluidic system 308. The fluidic system may couple to a canister (201, 202). The canister may comprise a canister lid 201 and a canister vessel 202. The canister lid may comprise a filter 209, which can prevent water, earwax, etc., from ingressing into the pump 405 of the fluidic system thereby preventing damage to the pump and / or other fluidic system components. The canister vessel and / or canister lid may be secured within the fluidic system using a first magnet 210 disposed in the canister lid 201 coupled to a second magnet 211 disposed in the fluidic system 308. The fluidic system may interface with a collar 301 composed of two silicon halves. The collar may comprise a magnet 302 that couples with a magnet inside the housing of the fluidic system 303. A probe / suction applicator 307 may be inserted into a subject’s ear. The probe / suction applicator 307 may be attached to a suction hose 306, and a biological sample, e.g., water, earwax, etc. 403 may flow from the subject’s ear into the probe / suction applicator 307. The biological sample may then flow through the suction hose 306 to canister lid 201 and into the canister vessel 202. The fluidic system may comprise a dual head pump 405, a battery 407 that powers the fluidic system when it is remotely operated, and capacitors of a circuit (e.g., printed circuit board (PCB)) 408 embedded system that provides one or more electrical signals to the pump to actuate the pump and provide suction to the probe and / or suction applicator. Air may flow through the canister filter 209 and canister lid 201 and into the bellows 204 and dual head pump 405, as indicated by the white arrows shown on FIG. 4. The air may then flow through internal tubing, the dual head pump 405, additional tubing, and a sound attenuator 100, 120, 140, described elsewhere herein, before being expelled inside the fluidic system cavity.

[0078]

[0074] FIG. 5 shows a diagram of different components of the fluidic system and how they work together. A biological sample of e.g., water, earwax, etc., may flow from the subject’s ear into the canister lid 201, as indicated by arrow 403. The fluidic system may comprise a sound attenuator 100, 120, 140 coupled to one or more inlets or outlets of the fluidic system or one or more components or elements thereof. The fluidic system may comprise a pump 405. In some cases, the pump 405 may comprise a dual head pump. The fluidic system may comprise a proportional valve filter 501. Ambient air inside the pump housing may enter into the proportional valve filter 501. The proportional valve filter 501 may be connected to a valve 503, which allows for ambient air 502 (e.g., from an atmosphere external to the fluidic system) to flow into the system, decreasing the suction of the pump 405. The fluidic system may be able to vary vacuum pressure between about 69 kPa and about 92 kPa. The fluidic system may be enclosed in a housing 504. A fluidic connector 505 may connect to the vacuum side of the fluidic circuit. A fluidic connector 506 may connect to the overpressure side of the fluidic circuit. The vacuum side of the fluidic circuit may sit between the canister (201, 202) and the pump 405. The valve 503 may allow this section to slightly open to the atmosphere and allow vacuum pressure to drop. The overpressure side of the fluidic circuit may sit between the pump 405 and the sound attenuator 100, 120, 140. While the vacuum side of the fluidic circuit may allow pressure to drop and encourage airflow into the fluidic system, the overpressure side of the fluidic circuit may increase pressure and encourage air to flow out of the fluidic system. Exhaust air 507 may be flow out of the sound attenuator 100, 120, 140 and into an environment and / or atmosphere inside and / or outside the housing 504. A fluidic connector 508 may couple the valve 503 and the vacuum side of the fluidic circuit.

[0079]

[0075] FIG. 6 shows a perspective view of the exterior of the fluidic system 308 with a canister vessel, canister lid, and suction hose coupled to the fluidic system 308. The fluidic system 308 may couple to a canister (201, 202), the canister comprising a canister lid 201 and a canister vessel 202. The fluidic system may comprise a suction hose 306 coupled to an adapter 304 that may couple to a probe and / or suction applicator 307, where the probe and / or suction applicator may be inserted into a subject’s ear. The fluidic system may comprise an interface 602, e.g., buttons controlling on / off power and / or suction pressure of the fluidic system. The fluidic system may comprise a handle 603 (e.g., a flip-up handle) and a barrel jack 604 for charging a battery 407, described elsewhere herein, and / or providing in-line power to power a pump and / or other electronic components (e.g., control circuitry) of the fluidic system.

[0080]

[0076] FIG. 7 shows a probe and / or suction applicator 307 connected to an otoscope system 701. The otoscope system may be used to measure, quantify, determine, identify, and / or characterize the collected body fluid and / or biological sample, e.g., earwax, of a subject. In some cases, the measurement, quantification, determination, identification, and / or characterization of the bodily fluid and / or biological sample may comprise measuring, quantifying, determining, and / or identifying DNA, RNA, nucleic acid molecules, nucleic acid molecule genomic aberrations (e.g., insertions deletion mutations (INDELS)), single nucleotide polymorphism (SNP), copy number variation, or any combination thereof, of one or more nucleic acid molecules of the bodily fluid and / or biological sample of the subject. In some cases, the measure, quantification, determination, identification, and / or characterization of the bodily fluid and / or biological sample of the subject may comprise measuring, quantifying, determining, and / or identifying proteomic, transcriptomic, methylome, and / or epigenomic markers of the bodily fluid and / or biological sample of the subject.

[0081]

[0077] FIG. 8 shows the fluidic system 308 and otoscope system 701 used with an ear phantom 802. The fluidic system may comprise a suction hose 306 coupled to an adapter 304, where the adapter is coupled to a probe / suction applicator 307 that may be inserted into a subject’s ear.

[0082]

[0078] FIG. 11 shows an exploded view of an assembled canister lid 201. The canister lid 201 may comprise a filter 209, which can prevent water, earwax, etc., from ingressing into the pump of the fluidic system thereby preventing damage to the pump and / or other fluidic system components. A cover 1101 may fit over the filter 209. The canister lid 201 may comprise a canister magnet 210. The canister magnet 210 may be secured within the canister lid 201 using an adhesive 1103. The adhesive 1103 may comprise melt glue, epoxy, cyanoacrylate, RTV, or any other adhesive that is REACH-compliant. The adhesive 1103 may be applied as a viscous liquid and allowed to dry into approximately the shape shown in 1103. The cover 1101 may act to ensure the filter is retained in the canister lid 201. The cover may also create a labyrinth for air and other fluids to flow through and / or around the canister lid 201, to allow bodily fluids and / or biological samples of a subject to separate from air suction and deposit into the canister vessel before reaching the filter 209. Preventing the exposure of the filter to bodily fluids and / or biological samples of the subject may prolong the operating life of the filter. Once this the filter 209 does absorb bodily fluids and / or a biological sample of the subject, the filter may self-seal to a curved body 1201 of the canister lid 201, dropping the suction pressure and / or flow rate of the fluidic system. When flow rates and / or suction of the fluidic system decrease conspicuously and / or under a threshold flow rate and / or suction strength, the user may be instructed to replace the canister lid 201. The canister lid magnet 201 may be designed to attract and / or couple to a magnet 211 disposed within the fluidic system 308, thereby providing a user a tactile sensation that the canister is secure within the fluidic system housing and ready for use.

[0083]

[0079] While the systems, devices, and / or methods described herein have been described in relation to use with an ear, such as to collect cerumen or earwax, the systems, devices, and / or methods described herein may also be applicable for other bodily orifices, openings, or surface areas, including but not limited to, the scalp, the skin, hair, the eyes, the nose, the mouth, the esophagus, the trachea, the urethra, the vagina, the cervix, the anus, the rectum, to name a few.

[0084]

[0080] While preferred embodiments of the present invention have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the invention. It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention. It is intended that the following claims define the scope of the invention and that methods and structures within the scope of these claims and their equivalents be covered thereby.

[0085]

[0081] The disclosure of this application also includes the following numbered clauses:

[0086] 1. A device for receiving a biological sample of a subject, comprising:

[0087] (a) a lid at least partially covering a first curved body concentric with a second curved body; and

[0088] (b) a canister vessel removably coupled to said lid, wherein said lid is fluidically coupled to said canister vessel, and wherein said canister vessel is configured to receive said biological sample of said subject.

[0089] 2. The device of clause 1, further comprising a filter fluidically coupled to said lid, said canister vessel, or a combination thereof.

[0090] 3. The device of clause 2, wherein said filter is disposed in said lid.

[0091] 4. The device of clauses 2 or 3, wherein said filter is disposed within said first curved body.

[0092] 5. The device of any one of clauses 2-4, wherein said filter is configured to swell when said filter absorbs said biological sample of said subject.

[0093] 6. The device of any one of clauses 2-5, wherein said filter self-seals to said first curved body.

[0094] 7. The device of any one of clauses 2-6, wherein said first curved body concentric with said second curved body provides a flow of a fluid of at least about 14.5 liters per minute between said lid, said filter, said canister vessel, or any combination thereof. The device of any one of clauses 2-7, wherein said first curved body concentric with said second curved body provides a laminar flow of fluid between said lid, said filter, said canister vessel, or a combination thereof. The device of any one of clauses 2-8, wherein said filter is covered by a third body. The device of any one of clauses 1-9, wherein said biological sample comprises ear wax or a bodily fluid of said subject. The device of any one of clauses 1-10, wherein said canister vessel, said lid, or any combination thereof is fluidically coupled to a pump. The device of clause 11, wherein said canister vessel, said lid, or any combination thereof is fluidically coupled to a valve, wherein said valve is fluidically coupled to the atmosphere. The device of clause 12, wherein said valve decreases suction of said pump when said valve is opened. A device for attenuating sound, comprising:

[0095] (a) a first body comprising an inlet coupled to an output of a pump;

[0096] (b) a second body comprising an outlet, wherein said second body is coupled to said first body, and wherein an axis of said outlet is offset from an axis of said inlet; and

[0097] (c) a material disposed within said first body and said second body configured to attenuate sound of said pump. The device of clause 14, wherein said material comprises a polymer fiber, foam, cotton, or any combination thereof. The device of clauses 14 or 15, wherein said outlet is fluidically coupled to the atmosphere. The device of any one of clauses 14-16, wherein said first body and / or said second body is injection molded. The device of any one of clauses 14-17, wherein said sound of said pump is attenuated by at least about lOdB. The device of any one of clauses 14-18, wherein said first body or said second body comprise a length of about 1 / 32 of a standing wave frequency of said sound of said pump. The device of any one of clauses 14-19, wherein said first body or said second body are made of acrylonitrile butadiene styrene (ABS). The device of any one of clauses 14-20, wherein said first body is ultrasonically welded to said second body. A system for receiving a biological sample of a subject, comprising:

[0098] (a) a fluidic system interface comprising a track and a nozzle receptacle; and

[0099] (b) a lid comprising a nozzle and a rail, wherein said lid is configured to be removably coupled to a canister vessel, wherein said rail of said lid is configured to mechanically couple to said track, wherein said nozzle is configured to couple to said nozzle receptacle when a first magnet of said lid is at a distance from a second magnet disposed in the fluidic system, and wherein said canister vessel is configured to receive said biological sample of said subject. The system of clause 22, wherein said biological sample comprises ear wax or a bodily fluid of said subject. The system of clauses 22 or 23, wherein said lid comprises a filter. The system of clause 24, wherein said filter self-seals in said lid. The system of clauses 24 or 25, wherein said filter is configured to swell when said filter absorbs said biological sample of said subject. The system of any one of clauses 22-26, wherein said fluidic system interface is coupled to a pump. The system of clause 27, wherein said fluidic system interface is fluidically coupled to a valve, wherein said valve is fluidically coupled to the atmosphere. The system of clause 28, wherein said valve decreases suction of said pump when said valve is opened. A method for receiving or obtaining a biological sample of a subject, comprising: receiving or obtaining said biological sample of said subject through a lid into a canister vessel, wherein said lid is fluidically coupled to said canister vessel, wherein said lid comprises a first curved body concentric with a second curved body, and wherein said lid is removably coupled to said canister vessel. The method of clause 30, wherein said lid, said canister vessel, or a combination thereof are fluidically coupled to a filter. The method of clause 31, wherein said filter is disposed in said lid. The method of clauses 31 or 32, wherein said filter is disposed within said first curved body. The method of any one of clauses 31-33, wherein said filter is configured to swell when said filter absorbs said biological sample of said subject. The method of any one of clauses 31-34, wherein said filter self-seals to said first curved body. The method of any one of clauses 31-35, wherein said first curved body concentric with said second curved body provides a flow of a fluid of at least about 14.5 liters per minute between said lid, said filter, said canister vessel, or any combination thereof. The method of any one of clauses 31-36, wherein said first curved body concentric with said second curved body provides a laminar flow of a fluid between said lid, said filter, said canister vessel, or any combination thereof. The method of any one of clauses 31-37, wherein said filter is covered by a third body. The method of any one of clauses 30-38, wherein said biological sample comprises ear wax or a bodily fluid of said subject. The method of any one of clauses 30-39, wherein said lid, said canister vessel, or a combination thereof, is fluidically coupled to a vacuum pump. The method of clause 40, wherein said canister vessel, said lid, or a combination thereof is fluidically coupled to a valve, wherein said valve is fluidically coupled to the atmosphere. The method of clause 41, wherein said valve decrease suction of said vacuum pump when said valve is opened. A method for reducing an auditory output of a pump, comprising:

[0100] (a) providing a pump fluidically coupled to a sound attenuator, wherein said sound attenuator comprises a first half comprising an inlet and a second half comprising an outlet, and wherein a first central axis of said inlet and a second central axis of said outlet are offset by a distance, and wherein a material is disposed within said first half and said second half of said sound attenuator; and

[0101] (b) reducing an auditory output of said pump when said pump is fluidically coupled to said sound attenuator and is actuated. The method of clause 43, wherein said material comprises a polymer fiber, foam, cotton, or any combination thereof. The method of clauses 43 or 44, wherein said outlet is fluidically coupled to the atmosphere. The method of any one of clauses 43-45, wherein said first body or said second body is injection molded. The method of any one of clauses 43-46, wherein said auditory output of said pump is attenuated by at least about lOdB. The method of any one of clauses 43-47, wherein said first body or said second body comprise a length of about 1 / 32 of a standing wave frequency of said auditory output of said pump. The method of any one of clauses 43-48, wherein said first body and / or said second body are made of acrylonitrile butadiene styrene (ABS). The method of any one of clauses 43-49, wherein said first body is ultrasonically welded to said second body. A method for coupling a nozzle with a fluidic system interface, comprising: providing said fluidic system interface, wherein said fluidic system interface comprises a track and a nozzle receptacle; translating a rail mechanically coupled to a canister lid along said track of said fluidic system interface; and coupling a nozzle of said canister lid with said fluidic system interface when a first magnet disposed in said nozzle is at a distance from a second magnet disposed in said fluidic system. The method of clause 51, wherein said canister lid is configured to receive a biological sample. The method of clause 52, wherein said biological sample comprises ear wax or a bodily fluid. The method of any one of clauses 51-53, wherein said canister lid comprises a filter. The method of clause 54, wherein said filter self-seals in said canister lid. The method of clauses 54 or 55, wherein said filter is configured to swell when said filter absorbs said biological sample of said subject. The method of any one of clauses 51-56, wherein said fluidic system interface is coupled to a pump. The method of clause 57, wherein said fluidic system interface is fluidically coupled to a valve, wherein said valve is fluidically coupled to the atmosphere. The method of clause 58, wherein said valve decreases suction of said pump when said valve is opened. A device configured to couple a probe and / or suction applicator to a fluidic system, comprising: a body comprising a first magnet, wherein said body is configured to mechanically couple to a surface of said probe and / or suction applicator, and wherein said first magnet is configured to couple to a second magnet of said fluidic system. The device of clause 60, wherein said body comprises a first body and a second body. The device of clause 61, wherein said first body and said second body are comprised of an injection molded material. The device of any one of clauses 60-62, wherein said probe and / or suction applicator comprises a suction tubing or a suction rigid body. The device of any one of clauses 60-63, wherein said body comprises a curved surface configured to couple to said surface of said probe and / or suction applicator. The device of any one of clauses 60-64, wherein said body mechanically couples to a surface of said probe and / or suction applicator with an interference fit, snap fit, or a slip fit. The device of any one of clauses 60-65, wherein said body comprises a surface, wherein said surface of said body produces a frictional force when said surface of said probe and / or suction applicator is translated over said surface of said body thereby fixing a position of said body on said probe and / or suction applicator. The device of any one of clauses 60-66, wherein said second magnet is disposed adjacent a surface of the fluidic system. A method for coupling a probe and / or suction applicator to a fluidic system, comprising: suctioning a subject’s ear with said probe and / or suction applicator; and coupling a first magnet of a body mechanically coupled to a surface of said suction to a second magnet of said fluidic system fluidically coupled to said probe and / or suction applicator. The method of clause 68, wherein said body comprises a first body and a second body. The method of clause 69, wherein said first body and said second body are comprised of an injection molded material. The method of any one of clauses 68-70, wherein said probe and / or suction applicator comprises a suction tubing or a suction rigid body. The method of any one of clauses 68-71, wherein said body comprises a curved surface configured to couple to said surface of said probe and / or suction applicator. The method of any one of clauses 68-72, wherein said body mechanically couples to a surface of said probe and / or suction applicator with an interference fit, snap fit, or a slip fit. The method of any one of clauses 68-73, wherein said body comprises a surface, wherein said surface of said body produces a frictional force when said surface of said probe and / or suction applicator is translated over said surface of said body thereby fixing a position of said body on said probe and / or suction applicator. The method of any one of clauses 68-74, wherein said second magnet is disposed adjacent a surface of the fluidic system.

Claims

1. CLAIMS1. A device for attenuating sound, comprising: an inlet configured to receive a fluid from a pump of a fluidic system; an outlet; a body comprising an interior fluidically coupled to the inlet and the outlet; and a flow control structure comprising a plurality of elongate channels; wherein the flow control structure is arranged within the interior of the body such that the flow control structure defines a plurality of flow paths from the inlet to the outlet through the elongate channels, each flow path passing from one end of the elongate channels to another end of the elongate channels at least twice.

2. The device of claim 1, wherein each flow path comprises a sigmoidal portion and / or passes through at least three of the elongate channels.

3. The device of claim 2, wherein the body comprises: a first chamber fluidically coupled to the inlet via a first portion of the channels; and a second chamber fluidically coupled to the outlet via a second portion of the channels; wherein the first chamber is fluidically coupled to the second chamber via a third portion of the channels; and wherein each flow path passes through the first and second chambers.

4. The device of any preceding claim, wherein the flow control structure comprises a matrix of parallel elongate channels.

5. The device of claim 4 as dependent on claim 3, wherein the inlet is attached to the first portion of channels at a first end of the matrix and the outlet is attached to the second portion of channels at a second end of the matrix, wherein the first chamber is adjacent the second end of the matrix and the second chamber is adjacent the first end of the matrix.

6. The device of any preceding claim, wherein each channel has a constant cross-section perpendicular to its length, optionally a circular or hexagonal cross-section.

7. The device of any preceding claim, wherein each channel has a diameter that is no more than 50%, no more than 25% or no more than 10% of a diameter of the inlet and / or the outlet.

8. The device of any preceding claim, wherein an axis of the outlet is offset from an axis of the inlet.

9. The device of any preceding claim, wherein the outlet is fluidically coupled to a surrounding atmosphere.

10. The device of claim 9, wherein the outlet is shaped to direct fluid received from the inlet via the flow control structure towards the pump.

11. The device of any preceding claim, wherein the flow control structure is configured to attenuate sound emitted by the pump by at least about 10 dB.

12. The device of any preceding claim, wherein the body comprises a length of about 1 / 32 of a standing wave frequency of sound emitted by the pump.

13. The device of any preceding claim, wherein the device has a monolithic structure and / or is formed by 3D printing.

14. The device of any preceding claim, wherein the device is made of acrylonitrile butadiene styrene, ABS.

15. The device of any preceding claim, wherein the fluid from the pump comprises one or more exhaust gases output by the pump.

16. The device of any preceding claim, wherein the inlet is fluidically coupled to the pump.

17. A device for attenuating sound, comprising:(a) a first body comprising an inlet coupled to an output of a pump;(b) a second body comprising an outlet, wherein said second body is coupled to said first body, and wherein an axis of said outlet is offset from an axis of said inlet; and(c) a material disposed within said first body and said second body configured to attenuate sound of said pump.

18. The device of claim 17, wherein said material comprises a polymer fiber, foam, cotton, or any combination thereof.

19. The device of claims 17 or 18, wherein said outlet is fluidically coupled to the atmosphere.

20. The device of any one of claims 17 to 19, wherein said first body and / or said second body is injection molded.

21. The device of any one of claims 17 to 20, wherein said sound of said pump is attenuated by at least about lOdB.

22. The device of any one of claims 17 to 21, wherein said first body or said second body comprise a length of about 1 / 32 of a standing wave frequency of said sound of said pump.

23. The device of any one of claims 17 to 22, wherein said first body or said second body are made of acrylonitrile butadiene styrene, ABS; and / or wherein said first body is ultrasonically welded to said second body.

24. A fluidic system for collecting earwax of a subject, the system comprising: a canister configured to fluidically couple to a suction applicator and collect earwax received from the suction applicator; a pump fluidically coupled to the canister and configured to generate suction through the canister; and the sound attenuation device of any preceding claim, wherein the inlet of the device is fluidically coupled to an outlet of the pump.

25. The fluidic system of claim 24, wherein the outlet of the sound attenuation device is shaped to direct fluid towards a surface of the pump to provide cooling.

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