Multicomponent compositions for forming hydrogels and deploying precipitating agents in-situ
A multicomponent hydrogel composition with separate mixtures forming in situ and precipitating agents addresses the challenges of long preparation times and inaccurate deployments, enabling precise placement of radiation spacers and other agents to protect healthy tissues during therapy.
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- CLEASTREAM TECH LTD
- Filing Date
- 2024-12-12
- Publication Date
- 2026-06-18
AI Technical Summary
Radiation therapy can damage healthy tissues surrounding the treatment area, and existing hydrogel spacers for protecting these tissues have long preparation times and inaccurate deployments.
A stable, ready-to-inject multicomponent composition for forming hydrogels in situ, comprising a first mixture with a complexing component and a basic solution, and a second mixture with a branching component and a precipitating agent soluble in an organic solvent but insoluble in aqueous solvent, which are separately stored to prevent premature reaction, and combined in situ to form a hydrogel with the precipitating agent precipitating within the matrix.
The solution allows for rapid, accurate deployment of hydrogels with embedded precipitating agents, such as radiopaque agents, at specific locations within the body, reducing radiation damage to healthy tissues and improving treatment precision.
Smart Images
Figure 1 Figure 2 
Figure 3