Light irradiation device and light irradiation system

Abstract

A laser beam emitting portion 11 emits a laser beam toward the outside of a light irradiation device 2 in an emission direction Lout that intersects the longitudinal axial direction of the light irradiation device 2. A marker portion 30 has rigidity and radiopacity. The marker portion 30 includes a longitudinal axial direction marker portion 31 and an emission direction marker portion 32. The longitudinal axial direction marker portion 31 extends along the longitudinal axial direction of the light irradiation device 2. The emission direction marker portion 32 protrudes from the longitudinal axial direction marker portion 31 in a direction parallel to the emission direction Lout when the light irradiation device 2 is viewed from a direction extending along the longitudinal axial direction. The emission direction marker portion 32 is located on the proximal side relative to the distal-most end part of the longitudinal axial direction marker portion 31.

Description

Light Irradiation Device and Light Irradiation System

[0001] The present disclosure relates to a light irradiation device and a light irradiation system that are inserted into a living body lumen or the like to irradiate light.

[0002] In recent years, research on photoimmunotherapy, a technology for treating diseases, has been conducted. In photoimmunotherapy, after a drug that accumulates in cells in the diseased area (e.g., cancer cells, etc.) is administered to the living body, light (e.g., near-infrared light, etc.) is irradiated onto the diseased area. As a result, the drug reacts to the light and the cells in the diseased area are destroyed.

[0003] In photoimmunotherapy, a light irradiation device that irradiates laser light from a living body lumen (e.g., blood vessels, etc.) closer to the diseased area rather than irradiating light from the body surface has been proposed. For example, the light irradiation device described in Patent Document 1 has a laser light source at its tip. The laser light is emitted from the light emission part of the laser light source in a direction intersecting the longitudinal axis direction of the light irradiation device. Also, the light irradiation device described in Patent Document 2 includes an optical fiber that transmits the light emitted by the light source to the tip. The tip of the optical fiber is formed at a bent portion. The laser light is emitted from the foremost end of the bent portion of the optical fiber in a direction intersecting the longitudinal axis direction of the light irradiation device.

[0004] Also, when performing treatment by inserting a light irradiation device into a living body lumen, medical staff (e.g., doctors, etc.) can irradiate laser light toward the diseased area while confirming the position of the light irradiation device inside the living body based on a radiation image taken using radiation (e.g., X-rays, etc.). For example, the light irradiation device described in Patent Document 3 includes a radiation-impermeable marker portion at a position close to the light emission portion where the laser light is emitted. In Patent Document 3, the aim is to enable medical staff to grasp the position of the light emission portion based on the position of the marker portion shown in the radiation image.

[0005] Japanese Patent No. 7444519, Japanese Patent No. 7336119, Japanese Unexamined Patent Application Publication No. 2020 - 185257

[0006] When performing treatment using radiographic imaging, if medical professionals can understand not only the position of the light-emitting part from which the laser light is emitted, but also the direction of the laser light emitted from the light-emitting part, it becomes easier to irradiate the laser light to a more accurate location. Furthermore, it is desirable that the light irradiation device can be smoothly inserted into the insertion site of a biological lumen or catheter, etc. With conventional light irradiation devices, it has been difficult to achieve both the proper understanding of the direction of laser light emission and smooth insertion into the insertion site.

[0007] A typical object of this disclosure is to provide a light irradiation device and light irradiation system that allows medical personnel to appropriately understand the direction of laser light emission and that can be smoothly inserted into the insertion site.

[0008] A typical embodiment of the light irradiation device provided in this disclosure is a long-length medical light irradiation device having an elongated external shape, comprising: a rotation transmission member that transmits rotation between a base end and a tip end; a laser beam emission section provided at the tip end of the light irradiation device that emits laser beam in an emission direction intersecting the long axis direction of the light irradiation device, outside the light irradiation direction; and a marker section connected to the rotation transmission member at the tip end of the light irradiation device and having rigidity and radiopaqueness, wherein the marker section comprises a long axis marker section extending along the long axis direction, and an emission direction marker section that protrudes from the long axis marker section in a direction parallel to the emission direction when the light irradiation device is viewed from a direction along the long axis direction, and the emission direction marker section is located closer to the base end than the tip end of the long axis marker section.

[0009] A typical embodiment of the present disclosure provides a light irradiation system for medical use, comprising: a catheter formed in the shape of a long tube; and a long light irradiation device inserted into the lumen of the catheter, wherein the light irradiation device has a long outer shape and comprises: a rotation transmission member that transmits rotation between a proximal end and a tip end; a laser beam emission section provided at the tip of the light irradiation device that emits laser light in an emission direction intersecting the long axis of the light irradiation device, outside the light irradiation direction; and a marker section connected to the rotation transmission member at the tip of the light irradiation device and having rigidity and radiopaqueness, wherein the marker section comprises: a long axis marker section extending along the long axis; and an emission direction marker section that protrudes from the long axis marker section in a direction parallel to the emission direction when the light irradiation device is viewed from a direction along the long axis, wherein the emission direction marker section is located on the proximal end side of the furthest tip of the long axis marker section.

[0010] According to the light irradiation device and light irradiation system described herein, the direction of laser light emission can be appropriately understood by medical personnel, and the device can be smoothly inserted into the insertion site.

[0011] The light irradiation device disclosed herein is a long-length medical light irradiation device comprising a rotation transmission member, a laser light emission section, and a marker section. The rotation transmission member has a long-length shape. The rotation transmission member transmits rotation between its base end and its tip end. The laser light emission section is provided at the tip of the long-length device body. The laser light emission section emits laser light from the outside of the light irradiation device in a direction intersecting the long axis of the light irradiation device (hereinafter referred to as the "emission direction"). The marker section is connected to the rotation transmission member at the tip of the light irradiation device. The marker section is rigid and radiopaque. The marker section comprises a long axis marker section and an emission direction marker section. The long axis marker section extends along the long axis of the light irradiation device. The emission direction marker section protrudes from the long axis marker section in a direction parallel to the emission direction when the light irradiation device is viewed from a direction along the long axis. The emission direction marker section is located closer to the base end than the furthest tip of the long axis marker section.

[0012] When the light irradiation device disclosed herein is inserted into a biological lumen and imaged using radiation, the radiopaque marker portion (long axis marker portion and emission direction marker portion) is captured in the radiation image. Therefore, medical professionals can appropriately determine the emission direction of the laser beam by determining the direction in which the emission direction marker portion protrudes relative to the long axis marker portion from the radiation image. Here, since the marker portion has a moderate rigidity, the emission direction of the laser beam indicated by the emission direction marker portion is more stable compared to when the marker portion is flexible.

[0013] Here, the emission direction marker portion protrudes in a direction intersecting the longitudinal axis. Therefore, when the light irradiation device is inserted into an insertion site such as a biological lumen or catheter, it is conceivable that the emission direction marker portion may get caught within the insertion site. However, the emission direction marker portion of this disclosure is located not at the very tip of the longitudinal axis marker portion, but on the proximal side of the very tip. As a result, the possibility of the emission direction marker portion getting caught within the insertion site is appropriately reduced compared to the case where the emission direction marker portion is located at the very tip of the longitudinal axis marker portion. In other words, if a rigid emission direction marker portion is located at the very tip of the longitudinal axis marker portion, the emission direction marker portion at the very tip is likely to get caught during movement within the insertion site. However, if the emission direction marker portion is located on the proximal side of the longitudinal axis marker portion, the diameter of the rigid portion near the very tip becomes smaller, making it less likely for the emission direction marker portion to get caught on the insertion site when moving through narrow insertion sites, etc. Therefore, the light irradiation device disclosed herein allows medical professionals to appropriately understand the direction of laser light emission and can be smoothly inserted into the insertion site.

[0014] The specific configuration of the laser light emission section can be selected as appropriate. For example, the light irradiation device may be equipped with a small laser light source near its tip. If the laser light source emits laser light directly to the outside of the light irradiation device in the direction of emission, the laser light emission section may be the part of the laser light source from which the laser light is emitted outwards. Alternatively, if the laser light emitted from the laser light source to the outside of the light source is reflected by a light-reflecting member and emitted to the outside of the light irradiation device in the direction of emission, the laser light emission section may be the reflective surface of the light-reflecting member. Furthermore, the light irradiation device may be equipped with an optical fiber that transmits the laser light emitted by the laser light source to the vicinity of the tip of the light irradiation device. In this case, the laser light emission section may be the leading edge of the optical fiber from which the laser light is emitted outwards, or it may be a reflective surface that reflects the laser light emitted from the optical fiber. The number of light emission sections equipped in the light irradiation device may be one or more.

[0015] The direction in which the emission direction marker protrudes can also be appropriately selected. For example, when the emission direction marker is viewed from the long axis, it may protrude from the long axis marker in the same direction as the laser beam emission direction. In this case, the direction in which the emission direction marker protrudes relative to the long axis marker coincides with the laser beam emission direction, making it easier to accurately determine the emission direction. Alternatively, when the emission direction marker is viewed from the long axis, it may protrude from the long axis marker in the opposite direction to the laser beam emission direction. In this case as well, the laser beam emission direction can still be accurately determined.

[0016] The direction of emission of laser light from the laser light emission unit toward the outside of the light irradiation device may be inclined at 80 to 100 degrees (preferably about 90 degrees) with respect to the long axis of the light irradiation device. Furthermore, it is desirable that the angle difference between the extension direction of the long axis marker unit and the protruding direction of the emission direction marker unit be as close as possible to the angle difference of the laser light emission direction with respect to the long axis (for example, 80 to 100 degrees, more preferably about 90 degrees). In this case, medical professionals can more accurately determine the direction of laser light emission by the emission direction marker unit that appears in the radiation image. However, if the protruding direction of the emission direction marker unit is parallel to the direction of laser light emission when viewed from a direction along the long axis of the light irradiation device, medical professionals can still determine the direction of laser light emission even if the angle of the emission direction marker unit with respect to the long axis marker unit is not in the range of 80 to 100 degrees.

[0017] The emission direction marker may be located closer to the base end than the laser beam emission part. In this case, it becomes easier to position the emission direction marker even closer to the base end compared to when the emission direction marker is located closer to the tip end than the laser beam emission part. As a result, the emission direction marker becomes even less likely to get caught in the insertion area.

[0018] However, it is also possible to install the emission direction marker on the tip side of the laser beam emission section. Even in this case, by installing the emission direction marker on the proximal end side of the long axis marker section, the light irradiation device can move more smoothly through the insertion site.

[0019] The emission direction marker portion may be positioned further towards the tip of the rotation transmission member from its leading edge. If the rotation transmission member is made of a radiopaque material, and the emission direction marker portion and the rotation transmission member are not spaced apart, it becomes difficult to determine the protruding direction of the emission direction marker portion by radiographic imaging, making it difficult to determine the emission direction of the laser light. In contrast, by positioning the emission direction marker portion further towards the tip of the rotation transmission member from its leading edge, it becomes easier to appropriately determine the protruding direction of the emission direction marker portion by radiographic imaging. Therefore, treatment can be performed more appropriately.

[0020] However, if the rotational transmission member is made of a material that transmits radiation, it is possible to manufacture the light irradiation device without separating the emission direction marker and the rotational transmission member.

[0021] The emission direction marker portion may be a member surrounding the central axis of the light irradiation device (for example, an annular member, or a partially annular member with a portion open), or a pair of members arranged opposite each other with the central axis in between. In this case, various objects (for example, at least one of a conductor, optical fiber, rotational transmission member, and coolant) can pass inside the emission direction marker portion. Therefore, the emission direction marker portion can be properly installed on the light irradiation device without obstructing the placement or passage of other objects.

[0022] The specific shape of the emission direction marker portion can be selected as appropriate. For example, the emission direction marker portion may be formed in an annular shape (e.g., a circular or polygonal annular shape) surrounding the central axis of the light irradiation device. Alternatively, the emission direction marker portion may be formed in a partially annular shape with a portion of the annular shape open. Furthermore, when the emission direction marker portion is formed by a pair of members, the shape of each member of the pair can be various shapes such as flat or curved.

[0023] A small laser light source that emits laser light may be provided at the tip of the light irradiation device. The rotation transmission member may be a hollow member. The hollow portion of the rotation transmission member may serve as a coolant flow path that allows coolant to pass from the base end to the laser light source. In this case, the hollow portion of the rotation transmission member can be used as a coolant flow path. By flowing coolant through the hollow portion of the rotation transmission member, the heat dissipation of the laser light source is more easily ensured. Furthermore, the emission direction marker portion is formed in a shape that surrounds the central axis of the light irradiation device, or in a pair of shapes that are arranged opposite each other with the central axis in between. As a result, the coolant supplied to the tip side through the hollow portion of the rotation transmission member passes smoothly inside the emission direction marker portion, so that the flow of coolant is less likely to be impaired by the emission direction marker portion. Therefore, the laser light source is more easily cooled appropriately.

[0024] Furthermore, the emission direction marker portion may be located between the tip of the rotation transmission member and the laser light source, which is positioned further forward than the rotation transmission member. In this case, the cooling liquid released from the tip of the hollow portion of the rotation transmission member smoothly passes inside the emission direction marker portion and reaches the laser light source. Therefore, the emission direction marker portion appropriately indicates the emission direction of the laser light while not hindering the cooling of the laser light source by the cooling liquid, nor hindering its movement within the insertion portion of the light irradiation device.

[0025] However, it is also possible to place the annular or other emission direction marker portion closer to the tip than the laser light source. Even in this case, the coolant that has passed near the laser light source will pass inside the emission direction marker portion and flow smoothly toward the tip. Therefore, obstruction of the coolant flow and a decrease in the cooling performance of the laser light source are appropriately suppressed.

[0026] Furthermore, instead of employing a technique that positions the emission direction marker portion closer to the base end than the leading edge of the longitudinal axis marker portion, it is also possible to employ techniques related to the emission direction marker portion, such as an annular shape, in the light irradiation device. In this case, the light irradiation device can also be described as follows.

[0027] A long, rectangular medical light irradiation device comprising: a long, rectangular external shape, a hollow rotation transmission member that transmits rotation between the base end and the tip end; a laser light source provided at the tip of the light irradiation device that emits laser light; a laser light emission section that emits the laser light emitted by the laser light source in an emission direction intersecting the longitudinal axis of the light irradiation device; and a marker section connected to the rotation transmission member at the tip of the light irradiation device, which is rigid and radiopaque, wherein the marker section is along the longitudinal axis A light irradiation device comprising: an extending longitudinal axis marker portion; and an output direction marker portion that protrudes from the longitudinal axis marker portion in a direction parallel to the output direction when the light irradiation device is viewed from a direction along the longitudinal axis, wherein the hollow portion of the rotation transmission member serves as a coolant flow path for passing a coolant that cools the laser light source from the base end side to the laser light source side, and the output direction marker portion is a member surrounding the central axis of the light irradiation device, or a pair of members arranged opposite each other with the central axis in between.

[0028] A small laser light source that emits laser light may be provided at the tip of the light irradiation device. A conductor may be electrically connected to the laser light source. The conductor extends from the base end to the tip end along the rotation transmission member. The conductor may be positioned inside the emission direction marker portion. In this case, there is no need to devise a shape to position the conductor outside the emission direction marker portion, which simplifies the configuration of the light irradiation device 2. However, it is also possible to position the conductor outside the emission direction marker portion.

[0029] Furthermore, if the rotational transmission member is hollow, the conductor may be placed on the outside of the hollow rotational transmission member. In this case, it becomes easier to reduce the diameter of the rotational transmission member. Therefore, it also becomes easier to reduce the overall diameter of the light irradiation device. Moreover, since the overall diameter of the light irradiation device can be reduced, it becomes easier to adjust the flexibility of the light irradiation device (i.e., flexibility in the direction intersecting the extension direction of the device). Therefore, insertion and manipulation of the light irradiation device into a living organism becomes easier. In addition, by placing the conductor on the outside of the rotational transmission member, the placement of the conductor becomes easier compared to when it is placed on the inside.

[0030] The laser beam emitter may be directly or indirectly fixed to a rigid marker section (e.g., a long-axis marker section). In this case, the marker section serves not only to allow medical professionals to understand the direction of laser beam emission, but also to fix the laser beam emitter. Furthermore, by fixing the laser beam emitter to the marker section, the relative relationship between the actual direction of laser beam emitted from the emitter and the direction of laser beam emission indicated by the emission direction marker section is also fixed. Therefore, medical professionals can more easily irradiate the laser beam to a more accurate position.

[0031] Furthermore, as mentioned above, the laser light emission portion may be part of the laser light source. In this case, the laser light source itself may be fixed to the marker portion. Alternatively, both the laser light source and the light reflecting member may be fixed to the marker portion. In addition, the laser light emission portion may be the light emission surface of an optical fiber. In this case, the optical fiber may be fixed to the marker portion.

[0032] Furthermore, various other components can be fixed to the marker portion. For example, at least one of the following may be fixed to the marker portion (e.g., a marker portion along the long axis): an optical sensor for detecting whether light is properly emitted from the laser beam emitter, and a temperature sensor for detecting the temperature near the tip of the light irradiation device. In this case, the marker portion serves not only to allow medical personnel to understand the direction of laser beam emission, but also to hold the component in a stable state.

[0033] At least the area around the tip of the light irradiation device may be covered with a flexible sealing member. At least the portion of the sealing member located in the laser beam path may be made of a material that transmits laser light. In this case, various problems caused by liquid or the like adhering to the laser beam emission part are appropriately suppressed. However, even if the tip of the light irradiation device is covered with a flexible sealing member, the marker portion is rigid, so there is a possibility that the emission direction marker portion may get caught at the insertion site. However, by positioning the emission direction marker portion closer to the base end than the leading edge of the longitudinal axis marker portion, the possibility of the emission direction marker portion getting caught at the insertion site is appropriately reduced.

[0034] Multiple light irradiation devices may be provided. For example, multiple light irradiation devices may be installed spaced apart in the longitudinal direction at the tip of the light irradiation device. In this case, the emission direction marker may be located between the multiple laser beam emitters. The emission direction marker is positioned between the multiple laser beam emitters, rather than at the very tip of the light irradiation device (further forward than the furthest laser beam emitter). As a result, the possibility of the emission direction marker getting caught in the insertion site when inserting the light irradiation device is appropriately reduced. Also, by positioning the emission direction marker between the multiple laser beam emitters, the distance between each laser beam emitter and the emission direction marker is shortened. This makes it easier for medical professionals to accurately grasp the position of each laser beam emitter that is adjacent to the marker in the longitudinal direction, as well as the direction of laser beam emission, by checking the orientation of one emission direction marker on the radiographic image. Therefore, even when irradiating with light using multiple light sources, both smooth insertion and ease of grasping the irradiation position can be achieved.

[0035] However, this is not necessarily the only option, and the placement of the emission direction marker can be changed as appropriate. For example, the emission direction marker may be positioned further towards the tip than all of the multiple laser beam emission sections, or further towards the base than all of the multiple laser beam emission sections. Alternatively, the emission direction marker may be positioned so as to overlap with one of the multiple laser beam emission sections in terms of the long axis (i.e., so that their positions in the long axis are the same). By positioning the emission direction marker so as to overlap with one of the multiple laser beam emission sections in terms of the long axis, it becomes easier to suppress the length of the tip in the long axis, thus facilitating insertion into curved biological tubular lumenes.

[0036] The light irradiation system disclosed herein is a medical light irradiation system comprising a catheter formed in the shape of a long tube and a long light irradiation device inserted into the lumen of the catheter. The light irradiation device comprises a rotation transmission member, a laser light emission section, and a marker section. The rotation transmission member has an elongated shape. The rotation transmission member transmits rotation between its proximal end and its tip end. The laser light emission section is provided at the tip of the long device body. The laser light emission section emits laser light from the outside of the light irradiation device in a direction intersecting the long axis of the light irradiation device (hereinafter referred to as the "emission direction"). The marker section is connected to the rotation transmission member at the tip of the light irradiation device. The marker section is rigid and radiopaque. The marker section comprises a long axis marker section and an emission direction marker section. The long axis marker section extends along the long axis of the light irradiation device. The emission direction marker section protrudes from the long axis marker section in a direction parallel to the emission direction when the light irradiation device is viewed from a direction along the long axis. The ejection direction marker is located closer to the base end than the leading edge of the longitudinal axis marker.

[0037] According to the light irradiation system disclosed herein, medical professionals can appropriately determine the direction of laser beam emission by determining the direction in which the emission direction marker portion protrudes relative to the longitudinal axis marker portion from the radiographic image. Furthermore, the emission direction marker portion is located not at the very tip of the longitudinal axis marker portion, but closer to the proximal end. As a result, the possibility of the emission direction marker portion getting caught at the insertion site is appropriately reduced.

[0038] An outlet may be formed in at least a portion of the tip of the catheter to discharge the cooling fluid from the inside to the outside of the catheter. In this case, the cooling fluid passes near the tip of the light irradiation device and is discharged to the outside through the outlet of the catheter. As a result, the cooling fluid is continuously supplied to the vicinity of the tip of the light irradiation device, making it easier to appropriately suppress the temperature rise near the tip. In addition, the possibility of blood from outside the catheter entering the inside of the tip of the light irradiation device is also appropriately reduced.

[0039] As mentioned above, the coolant may be flowed through the hollow portion of the rotational transmission member of the light irradiation device. Alternatively, the coolant may be flowed through the space between the lumen of the catheter and the light irradiation device.

[0040] The specific form of the outlet can be selected as appropriate. For example, a passage hole for a guidewire may be provided at the tip of the catheter. The guidewire passage hole may also serve as the outlet for the coolant. Alternatively, a separate coolant outlet may be formed at the tip of the catheter, distinct from the guidewire passage hole.

[0041] A drain valve may be provided at the catheter's outlet, allowing fluid to be discharged to the outside of the catheter through the outlet while preventing fluid from flowing in from the outside to the inside of the catheter. In this case, the drain valve prevents blood or other fluids from flowing into the inside of the catheter through the outlet.

[0042] FIG. 0 is a longitudinal sectional view of the light irradiation system 1 in a state where the light irradiation device 2 and the catheter 3 are separated. FIG. 1 is an enlarged longitudinal sectional view of the vicinity of the distal end portion of the light irradiation system 1 in a state where the light irradiation device 2 is attached to the catheter 3 (use state). FIG. 2 is a perspective view of the vicinity of the distal end portion of the light irradiation device 2. FIG. 3 is a perspective view of the vicinity of the distal end portion of the light irradiation device 25 of the first modification. FIG. 4 is a perspective view of the vicinity of the distal end portion of the light irradiation device 26 of the second modification. FIG. 5 is a perspective view of the vicinity of the distal end portion of the light irradiation device 27 of the third modification.

[0043] Hereinafter, typical embodiments in the present disclosure will be described with reference to the drawings. The light irradiation system 1 of the present embodiment is used by being inserted into the lumen of a living body (for example, at least any one of blood vessels, lymph glands, urethra, airway, digestive organs, secretory glands, and reproductive organs). The light irradiation system 1 irradiates light (laser light in this embodiment) to living tissue in a state of being inserted into the lumen of a living body. The light irradiation system can be used for at least any one of therapies such as PDT (Photodynamic Therapy) and NIR-PIT (Near-infrared Photoimmunotherapy).

[0044] As shown in FIGS. 1 and 2, the light irradiation system 1 of the present embodiment includes a light irradiation device 2 and a catheter 3. When the light irradiation system 1 is used, first, the catheter 3 is inserted into the living body lumen. Next, the light irradiation device 2 is inserted into the lumen 311 of the catheter 3 having a long tubular shape. When the insertion is completed, the living tissue is irradiated with light from the light irradiation device 2. However, it is also possible to use only the light irradiation device 2 alone without using the catheter 3.

[0045] In FIGS. 1 and 2, XY axes orthogonal to each other are shown. In these drawings, the lower side of the drawing (+X direction) is defined as the "distal end side", the upper side of the drawing (-X direction) is defined as the "proximal end side", the left side of the drawing (+Y direction) is defined as the "left side", and the right side of the drawing (-Y direction) is defined as the "right side". The light irradiation system 1, the light irradiation device 2, and the catheter 3 are inserted into the living body lumen from the distal end side. The proximal end side is operated by medical staff (for example, a doctor).

[0046] (Light Irradiation Device) Referring to FIGS. 1 to 3, the light irradiation device 2 of the present embodiment will be described. As shown in FIG. 1, the shape of the light irradiation device 2 is elongated. The light irradiation device 2 includes a connector 201, a device main body 210, a laser light emitting unit 11, and the like. The connector 201 is located at the proximal end side of the light irradiation device 2 and is held by the operator. The connector 201 includes a pair of blade portions 202 and a connection portion 203. The connection portion 203 is a substantially cylindrical member. The blade portion 202 is connected to the proximal end portion of the connection portion 203. The device main body 210 is connected to the distal end portion of the connection portion 203. Note that the blade portion 202 and the connection portion 203 may be integrally formed. The device main body 210 is an elongated member. Although details will be described later, the device main body 210 includes a rotation transmission member 20 and a marker portion 30. The laser light emitting unit 11 is a portion that emits laser light in a predetermined wavelength range to the outside of the light irradiation device 2 in an emission direction Lout (see FIGS. 2 and 3) that intersects the longitudinal axis direction of the device main body 210. In the present embodiment, the emission direction Lout of the laser light is a direction that perpendicularly intersects the longitudinal axis direction of the device main body 210. However, the emission direction Lout of the laser light only needs to intersect the longitudinal axis direction of the device main body 210, and does not necessarily need to perpendicularly intersect. The laser light emitting unit 11 is provided at the distal end portion of the elongated device main body 210.

[0047] As shown in FIGS. 2 and 3, the device main body 210 of the light irradiation device 2 includes a rotation transmission member 20. The outer shape of the rotation transmission member 20 is elongated and hollow. The rotation transmission member 20 transmits rotation (torque) between the proximal end side and the distal end side. In the rotation transmission member 20 of the present embodiment, a torque coil (multi-strand multi-layer coil) is used. However, it is also possible to use a rotation transmission member other than the torque coil.

[0048] As shown in FIGS. 2 and 3, the light irradiation device 2 of the present embodiment includes a small laser light source 10 near the distal end portion. The laser light source 10 is directly or indirectly connected to the rotation transmission member 20 at the distal end portion of the elongated device main body 210. In the present embodiment, the laser light source 10 is connected to the rotation transmission member 20 via a marker portion 30 described later.

[0049] The laser light source 10 may, for example, have a semiconductor laser element. The semiconductor laser element may be an end-face emitting laser element that irradiates laser light in a direction horizontal to the substrate, or a vertical-cavity surface emitting laser element that irradiates laser light in a direction perpendicular to the substrate. The light irradiation device 2 may, together with the laser light source 10, include at least one of a mirror, prism, lens, and diffractive optical element that changes the divergence angle of the laser light emitted from the laser light emission unit 11. In this embodiment, the laser light source 10 emits laser light from a light emission surface facing the +Y direction toward the emission direction Lot, and irradiates the outside of the light irradiation device 2. In other words, the laser light emission unit 11 in this embodiment is the light emission surface of the laser light source 10.

[0050] However, the configuration of the laser light emission section can also be changed. For example, the laser light emitted from the laser light source to the outside of the light source can be reflected by a light-reflecting member (e.g., a mirror) to emit the laser light to the outside of the light irradiation device 2 in the emission direction Lout. In this case, the laser light emission section may be the reflective surface of the light-reflecting member. The laser light source 10 may also be covered with a capsule that blocks the inflow of liquid from the outside into the laser light source 10. In this case, at least the portion of the capsule through which the laser light passes may be made of a material that transmits laser light. The light irradiation device 2 may also include an optical fiber that transmits the laser light emitted from the laser light source provided at the base end to the vicinity of the tip of the light irradiation device 2. In this case, the laser light emission section may be the leading edge surface of the optical fiber from which the laser light is emitted to the outside, or it may be a reflective surface that reflects the laser light emitted from the optical fiber.

[0051] The light irradiation device 2 of this embodiment includes a conductor 14. The conductor 14 extends along the device body 210 from the base end to the tip end and is electrically connected to the laser light source 10. The base end of the conductor 14 is connected to a control unit 5 (see Figure 1) which controls the light irradiation device 2. In this embodiment, the conductor 14 is directly connected to the laser light source 10. However, at least one of the conductors may be electrically connected to the laser light source 10 via another conductive member.

[0052] In this embodiment, a flexible insulated conductor is used for the conductor 14. Therefore, the shape of the conductor 14 deforms appropriately in accordance with changes in the shape of the device body 210 of the light irradiation device 2. In this embodiment, the conductor 14 is formed by insulating a metal wiring made of good conductor material such as Cu or Ni with an insulating coating of polyurethane. Alternatively, the metal wiring may be insulatingly coated with an insulating resin such as polyester, polyesterimide, polyamideimide, or polyimide instead of polyurethane. Furthermore, one conductor 14 in this embodiment constructs two or more transmission lines (lines that transmit at least one of power and / or signals to the laser light source 10) to the laser light source 10. As a result, the light irradiation device 2 is driven appropriately. Note that two or more conductors may be connected to the laser light source 10 separately.

[0053] However, it is also possible to change the configuration of the conductor 14. For example, a flexible printed circuit board (FPC board) may be used as the conductor. In this case as well, the shape of the conductor will be appropriately deformed according to the change in the shape of the device body 210 of the light irradiation device 2. Furthermore, a flexible circuit board equipped with multiple transmission lines (for example, a positive transmission line and a negative transmission line) may be used as the conductor. In this case, the number of conductors can be reduced, making it easier to reduce the amount of work required when manufacturing the light irradiation device 2. In addition, it goes without saying that if the laser light is transmitted to the tip using an optical fiber instead of a small laser light source 10 provided at the tip of the device body 210, the conductor 14 can be omitted.

[0054] As shown in Figures 2 and 3, the device body 210 of the light irradiation device 2 includes a marker portion 30. The marker portion 30 is made of a material that is radiopaque. Therefore, when the light irradiation device 2 is inserted into a biological lumen and imaging is performed using radiation, the marker portion 30 is captured in the radiation image. The marker portion 30 is connected directly or indirectly (directly in this embodiment) to the rotation transmission member 20 at the tip of the light irradiation device 2.

[0055] The marker unit 30 comprises a longitudinal axis marker unit 31 and an emission direction marker unit 32. The longitudinal axis marker unit 31 extends along the longitudinal axis of the light irradiation device 2. Therefore, medical professionals can determine the longitudinal axis of the light irradiation device 2 by determining the extension direction of the longitudinal axis marker unit 31 as seen in the radiographic image. The emission direction marker unit 32 protrudes from the longitudinal axis marker unit 31 in a direction parallel to the laser beam emission direction (LOT) when the light irradiation device 2 is viewed from a direction along the longitudinal axis. Therefore, medical professionals can appropriately determine the laser beam emission direction (LOT) by determining the direction in which the emission direction marker unit 32 protrudes relative to the longitudinal axis marker unit 31 from the radiographic image.

[0056] In this embodiment, the marker portion 30 (long axis marker portion 31 and output direction marker portion 32) is formed of a material having appropriate rigidity. Therefore, compared to the case where the marker portion 30 is flexible, the output direction of the laser beam indicated by the output direction marker portion 32 is more stable. In this embodiment, the long axis marker portion 31 and the output direction marker portion 32 are formed integrally. However, the long axis marker portion 31 and the output direction marker portion 32 may be made of separate members. Even in this case, it is sufficient that their relative positions are fixed by directly or indirectly fixing the long axis marker portion 31 and the output direction marker portion 32.

[0057] The emission direction marker portion 32 protrudes in a direction intersecting the long axis of the light irradiation device 2. Therefore, when the light irradiation device 2 is inserted into an insertion site such as a biological lumen or catheter 3, it is conceivable that the emission direction marker portion 32 may get caught within the insertion site. However, in this embodiment, the emission direction marker portion 32 is not located at the very tip of the long axis marker portion 31, but rather on the proximal side of the very tip. As a result, the possibility of the emission direction marker portion 32 getting caught within the insertion site is appropriately reduced compared to the case where the emission direction marker portion 32 is located at the very tip of the long axis marker portion 31. In other words, if a rigid emission direction marker portion 32 were to be located at the very tip of the long axis marker portion 31, the emission direction marker portion 32 at the very tip would be prone to getting caught during its movement within the insertion site. However, if the emission direction marker portion 32 is positioned closer to the base end than the leading edge of the longitudinal axis marker portion 31, the diameter of the rigid portion near the leading edge becomes smaller, making it less likely for the emission direction marker portion 32 to catch on the insertion site when moving through a narrow insertion site. Therefore, the light irradiation device 2 of this embodiment allows medical personnel to appropriately grasp the emission direction of the laser light and can be inserted smoothly into the insertion site.

[0058] In this embodiment, when the light irradiation device 2 is viewed from a direction along the long axis, the emission direction marker portion 32 protrudes from the long axis marker portion 31 in the same direction as the laser light emission direction (i.e., the +Y direction). Therefore, since the direction in which the emission direction marker portion 32 protrudes relative to the long axis marker portion 31 coincides with the laser light emission direction (Lot), the laser light emission direction can be easily determined appropriately. However, when the light irradiation device 2 is viewed from the long axis, the emission direction marker portion 32 may protrude from the long axis marker portion 31 in the opposite direction to the laser light emission direction (Lot). Even in this case, the laser light emission direction (Lot) can still be determined appropriately.

[0059] As described above, in this embodiment, the emission direction (Lot) of the laser light emitted from the laser light emission unit 11 toward the outside of the light irradiation device 2 is inclined perpendicular to the long axis of the light irradiation device 2 (or within a range of 80 to 100 degrees, close to perpendicular). Therefore, the angle difference between the projection direction of the emission direction marker unit 32 and the extension direction of the long axis marker unit 31 is set to perpendicular (or 80 to 100 degrees) so as to match as closely as possible with the angle difference of the laser light emission direction (Lot) with respect to the long axis. In this case, medical professionals can more accurately grasp the laser light emission direction (Lot) by observing the emission direction marker unit 32 in the radiation image. However, when the light irradiation device 2 is viewed from a direction along its long axis, if the protruding direction of the emission direction marker portion 32 is parallel to the emission direction of the laser light (Lot), then medical professionals can determine the emission direction of the laser light (Lot) even if the angle of the emission direction marker portion 32 with respect to the long axis marker portion 31 is not in the range of 80 to 100 degrees.

[0060] As shown in Figures 2 and 3, in the light irradiation device 2 of this embodiment, the emission direction marker portion 32 is located on the proximal end side of the laser light emission portion 11. Therefore, compared to the case where the emission direction marker portion 32 is located on the tip side of the laser light emission portion 11, it becomes easier to position the emission direction marker portion 32 even further towards the proximal end. As a result, the emission direction marker portion 32 becomes even less likely to get caught in the insertion area.

[0061] In the light irradiation device 2 of this embodiment, the emission direction marker portion 32 is provided at a position further towards the tip from the very tip of the rotation transmission member 20 (in this embodiment, the open end 22 on the tip side of the hollow rotation transmission member 20). If the rotation transmission member 20 is made of a material that is radiopaque, and the emission direction marker portion 32 and the rotation transmission member 20 are not spaced apart, it will be difficult to determine the protruding direction of the emission direction marker portion 32 by radiographic imaging, making it difficult to determine the emission direction of the laser light. However, by positioning the emission direction marker portion 32 further towards the tip from the very tip of the rotation transmission member 20, medical professionals can more easily determine the protruding direction of the emission direction marker portion 32 by radiographic imaging. Therefore, treatment can be performed more appropriately.

[0062] As shown in Figure 3, the emission direction marker portion 32 of this embodiment is formed in a shape that surrounds the central axis of the light irradiation device 2. Therefore, various objects can pass inside the emission direction marker portion 32. Thus, the emission direction marker portion 32 is properly installed on the light irradiation device 2 without obstructing the placement or passage of other objects. In this embodiment, the emission direction marker portion 32 is formed in an annular shape. However, the emission direction marker portion 32 may be formed in the shape of a polygonal annular or a partial annular shape.

[0063] In detail, in this embodiment, the hollow portion 21 of the rotational transmission member 20 serves as a coolant flow path that allows coolant to pass from the base end to the laser light source 10. Specifically, an open end 22 is formed at the tip of the rotational transmission member 20, opening the hollow portion 21 outwards (towards the tip). The coolant that has passed through the hollow portion 21 of the rotational transmission member 20 is discharged from the open end 22 toward the laser light source 10. Therefore, by flowing coolant through the hollow portion 21 of the rotational transmission member 20, the heat dissipation of the laser light source 10 is more easily ensured. Furthermore, since the emission direction marker portion 32 is formed in a shape that surrounds the central axis of the light irradiation device, the coolant supplied to the tip side through the hollow portion 21 of the rotational transmission member 20 passes smoothly inside the emission direction marker portion 32. As a result, the flow of coolant is less likely to be impaired by the emission direction marker portion 32. Therefore, the laser light source 10 is more easily cooled appropriately. Furthermore, various liquids that do not affect biological tissues (such as physiological saline) can be used as the coolant.

[0064] As described above, the emission direction marker portion 32 in this embodiment is located between the tip of the rotation transmission member 20 and the laser light source 10, which is positioned further forward than the rotation transmission member 20. However, the cooling liquid released from the tip of the hollow portion 21 of the rotation transmission member 20 smoothly passes inside the emission direction marker portion 32 and reaches the laser light source. Therefore, the emission direction marker portion 32 appropriately indicates the emission direction of the laser light, while not hindering the cooling of the laser light source 10 by the cooling liquid, and also not hindering the movement of the light irradiation device 2 within the insertion portion.

[0065] Furthermore, as shown in Figure 3, in this embodiment, the conductor 14 connected to the laser light source 10 is positioned inside the emission direction marker portion 32. Therefore, there is no need to devise a shape or other method to position the conductor 14 outside the emission direction marker portion 32, which makes it easier to simplify the configuration of the light irradiation device 2.

[0066] As shown in Figure 3, in the light irradiation device 2 of this embodiment, the conductor 14 connected to the laser light source 10 at the tip is located on the outside of the hollow portion 21 of the rotational transmission member 20, rather than inside. Therefore, it becomes easier to reduce the diameter of the rotational transmission member 20 compared to the case where the conductor 14 is inserted through the hollow portion 21 of the rotational transmission member 20. Thus, it also becomes easier to reduce the overall diameter of the light irradiation device 2. Furthermore, since the overall diameter of the light irradiation device 2 can be reduced, it becomes easier to adjust the flexibility of the light irradiation device 2 (i.e., flexibility in the direction intersecting the extension direction of the device). Thus, insertion and manipulation of the light irradiation device 2 into a living body becomes easier. In addition, compared to the case where the conductor 14 is placed in the hollow portion 21 of the rotational transmission member 20, the manufacturing of the light irradiation device 2 also becomes easier. Furthermore, as mentioned above, in the light irradiation device 2 of this embodiment, since the conductor 14 is not inserted through the hollow portion 21 of the rotational transmission member 20, the hollow portion 21 can be appropriately utilized as a coolant flow path.

[0067] As shown in Figure 3, in the light irradiation device 2 of this embodiment, the laser light emission unit 11 (the light emission surface of the laser light source 10 in this embodiment) is directly or indirectly fixed to a rigid marker unit 30 (specifically, a longitudinal axis marker unit 31). In other words, the marker unit 30 serves not only to allow medical personnel to understand the laser light emission direction (Lout), but also to fix the laser light emission unit 11. Furthermore, by fixing the laser light emission unit 11 to the marker unit 30, the relative relationship between the actual emission direction (Lout) of the laser light emitted from the laser light emission unit 11 and the emission direction (Lout) of the laser light indicated by the emission direction marker unit 32 is also fixed. Therefore, medical personnel can more easily irradiate the laser light to a more accurate position.

[0068] Furthermore, in this embodiment, components other than the laser beam emission unit 11 are also fixed to the marker unit 30. For example, in the example shown in Figures 2 and 3, an optical sensor 41 for detecting whether laser light is properly emitted from the laser beam emission unit 11, and a temperature sensor 42 for detecting the temperature near the tip of the light irradiation device 2 are fixed to the marker unit 30 (in this embodiment, the long axis marker unit 31). Therefore, in addition to the function of allowing medical personnel to understand the laser beam emission direction (Lout), the marker unit 30 also serves the function of holding the components in a stable state.

[0069] As shown in Figure 2, the tip of the light irradiation device 2 is covered with a flexible sealing member 16. (Note that in Figure 3, the sealing member 16 is not shown in order to facilitate understanding of its internal structure.) The sealing member 16 seals the laser light emission section 11 (laser light source 10 in this embodiment) inside, thereby suppressing the inflow of liquid into the laser light emission section 11. Furthermore, the sealing member 16 in this embodiment makes it easier to ensure the insulation of the laser light source 10. For example, the sealing member 16 can be made of an organic material such as a resin material, or an inorganic material. It is desirable that the sealing member 16 has antithrombotic properties, flexibility, thermal conductivity, and biocompatibility. For example, the resin material can be polyamide resin, polyimide resin, polyolefin resin, polyester resin, polyurethane resin, polycarbonate resin, polyethylene terephthalate resin, silicone resin, epoxy resin, acrylic resin, and fluororesin. For the inorganic material, for example, a coating obtained by applying a polysilazane solution and silicating it (hereinafter referred to as "polysilazane coating") can be used. A resin layer made of the aforementioned resin material may be provided on the surface of the polysilazane coating. Of the sealing member 16, at least the portion located in the path of the laser light (in this embodiment, the entire sealing member 16) is made of a light-transmitting material. As an example, the sealing member 16 in this embodiment uses a heat-shrinkable tube that shrinks when heat is applied while covering at least the outer circumference of the tip of the light irradiation device 2. Here, even if the tip of the light irradiation device 2 is covered with a flexible sealing member 16, the marker portion 30 is rigid, so there is a possibility that the emission direction marker portion 32 may get caught at the insertion site. However, by positioning the emission direction marker portion 32 on the base end side of the leading edge of the long axis marker portion 31, the possibility of the emission direction marker portion 32 getting caught at the insertion site is appropriately reduced.

[0070] Here, it is desirable that the sealing member 16 be formed with a smooth outer surface (for example, cylindrical) so as not to damage biological tissue. In contrast, the ejection direction marker portion 32 shown in Figure 3 is annular, so it is less likely to create dead space in the internal space of the sealing member 16. This further reduces the possibility that the ejection direction marker portion 32 may get caught at the insertion site.

[0071] Furthermore, annular marker components are readily available on the market in various sizes. Therefore, it is easy to select an appropriate component according to the specifications of the light irradiation device (such as diameter), which contributes to miniaturization of the device and reduction of manufacturing costs.

[0072] (Catheter) The catheter 3 of this embodiment will be described with reference to Figures 1 and 2. As shown in Figure 1, the catheter 3 has the shape of a long tube. The catheter 3 comprises a connector 301, a shaft 310, and a tip 320. The connector 301 is located on the proximal end side of the catheter 3 and is grasped by the operator. The connector 301 comprises a pair of wing portions 302 and a connecting portion 303. The connecting portion 303 is a substantially cylindrical member. The wing portions 302 are connected to the proximal end of the connecting portion 303. The shaft 310 is connected to the tip of the connecting portion 303. The wing portions 302 and the connecting portion 303 may be formed integrally.

[0073] The shaft 310, like the device body 210 of the light irradiation device 2, is preferably antithrombotic, flexible, and biocompatible. The shaft 310 is a long, tubular member extending along the axis O3 (see Figure 1). In this embodiment, the shaft 310 is formed in a hollow cylindrical shape with both the tip and proximal ends open. The lumen 311 inside the shaft 310 functions as a guidewire lumen for inserting a guidewire into the catheter 3 during catheter delivery. After the catheter 3 has been delivered, the lumen 311 functions as a device lumen for inserting the light irradiation device 2 into the catheter 3.

[0074] The tip 320 is connected to the tip of the shaft 310. The tip 320 has an outer shape that narrows in diameter from the proximal end to the tip end in order to allow the catheter 3 to advance smoothly within the lumen of the body. A through hole 321 is formed approximately in the center of the tip 320, penetrating in the direction of the axis O3. The inner diameter of the through hole 321 is smaller than the inner diameter of the lumen 311 of the shaft 310 and also smaller than the outer diameter of the tip portion of the light irradiation device 2. Furthermore, the outer diameter of the device body 210 and the tip portion of the light irradiation device 2 is less than or equal to the inner diameter of the lumen 311 of the catheter 3. At least a portion of the tip 320 (in this embodiment, the entire tip 320) is made of a radiopaque material. Therefore, the position of the tip portion of the catheter 3 can be appropriately determined by imaging using radiation.

[0075] In this embodiment, cooling liquid is supplied not only to the hollow portion 21 of the rotation transmission member 20 in the light irradiation device 2, but also to the lumen 311 of the catheter 3 (the space between the outer surface of the light irradiation device 2 and the inner surface of the lumen 311 of the catheter 3). As a result, malfunctions caused by temperature rise due to the laser light source 10 are further suppressed.

[0076] As shown in Figure 2, the tip side surface (or, in this embodiment, a part of the tip side surface) of the shaft 310 of the catheter 3 is provided with a light-transmitting section 330 that allows the laser light emitted by the laser light emission section 11 of the light irradiation device 2 to pass through to the outside. Therefore, the light irradiation system 1 of this embodiment is capable of selectively irradiating a specific location on a living body with laser light emitted in the emission direction Lot, which intersects the axis O3, by the laser light emission section 11 of the light irradiation device 2.

[0077] The shaft 310 of the catheter 3 is provided with a radiopaque catheter-side marker portion 332 located close to the light-transmitting portion 330. Therefore, when medical professionals use radiation to image the inside of a living body and irradiate living tissue with laser light using the light irradiation device 2, they can align the position of the laser light emission portion 11 of the light irradiation device 2 with the position of the catheter-side marker portion 332 that appears in the captured image, thereby appropriately irradiating the laser light from the light-transmitting portion 330 to the outside. This makes it easier to further improve the accuracy of treatment.

[0078] As shown in Figure 2, the tip of the catheter 3 has an outlet 341 that discharges coolant from inside the lumen 311 to the outside of the catheter 3. Therefore, the coolant supplied to the inside of the catheter 3 (in this embodiment, both the coolant supplied to the hollow portion 21 of the rotation transmission member 20 of the light irradiation device 2 and the coolant supplied to the lumen 311 of the catheter 3) passes near the tip of the light irradiation device 2 where the laser light emission unit 11 is installed and is discharged to the outside of the catheter 3 from the outlet 341. As a result, the coolant is continuously supplied to the vicinity of the laser light emission unit 11, making it easier to further suppress the temperature rise of the laser light emission unit 11 and its vicinity. In addition, the possibility of blood outside the catheter 3 coming into contact with internal components of the catheter 3 (for example, the laser light emission unit 11) is also appropriately reduced. Therefore, blood coagulation due to the heat of the laser light emission unit 11 is less likely to occur.

[0079] In this embodiment, the catheter 3 has a through-hole 321 in the tip 320 through which a guidewire is inserted during catheter delivery, which also serves as a cooling fluid outlet 341. Therefore, both catheter delivery and cooling near the laser beam emission unit 11 are performed appropriately while keeping the catheter 3's configuration simple. However, it is also possible to change the specific configuration of the catheter outlet. For example, the outlet may be formed on the side of the elongated tubular shaft 310, either separately from or together with the through-hole 321 in the tip 320. It is desirable that the outlet be formed further towards the tip of the catheter 3 in the extension direction, beyond the position where the laser beam emission unit 11 is located during use.

[0080] As shown in Figure 2, the outlet 341 of the catheter 3 is provided with an outlet valve 322 that allows liquid to be discharged to the outside of the catheter 3 through the outlet 341, while preventing liquid from flowing in from the outside to the inside of the catheter 3. As a result, the outlet valve 322 prevents blood and other fluids from the outside of the catheter 3 from flowing into the inside of the catheter 3 through the outlet 341.

[0081] (Modifications) The technology disclosed in the above embodiments is merely an example. Therefore, it is possible to modify the technology illustrated in the above embodiments. Referring to Figure 4, some modifications of the above embodiments will be described. Figure 4 is a perspective view of the vicinity of the tip of the light irradiation device 25 of the first modification. The light irradiation device 25 of the first modification and the light irradiation device 2 of the above-described embodiments (see Figures 1 to 3) have different shapes in the emission direction marker portion, but the same configuration can be adopted for other components. Therefore, in the following description, the same numbers will be used for parts that can adopt the same configuration as the above embodiments, and their descriptions will be omitted or simplified.

[0082] As shown in Figure 4, the emission direction marker portion 33 of the light irradiation device 25 in the first modified example is a pair of members arranged opposite each other with the central axis of the light irradiation device 25 in between. In this case as well, similar to the above embodiment, various objects (for example, the conductor 14 and coolant, etc.) can pass inside the pair of emission direction marker portions 33. Therefore, the emission direction marker portion 33 is properly installed on the light irradiation device 25 without obstructing the placement or passage of other objects.

[0083] Figure 5 is a perspective view of the vicinity of the tip of the light irradiation device 26 of the second modified example. Unlike the light irradiation device 2 of the previously described embodiment (see Figures 1 to 3), the light irradiation device 26 of the second modified example uses an optical fiber 17 instead of a laser light source 10 to emit laser light from the tip in the output direction Lot. The other configurations can be those of the previously described embodiment (see Figures 1 to 3).

[0084] As shown in Figure 5, the second modified optical irradiation device 26 includes an optical fiber 17 that transmits laser light emitted by a laser light source (not shown) provided at the base end to the vicinity of the tip of the optical irradiation device 2. The tip of the optical fiber 17 is bent into a predetermined shape, and the laser light emission portion 18 (i.e., the leading edge surface of the optical fiber 17) from which the laser light is emitted to the outside faces the emission direction Lout. As a result, the laser light is emitted from the laser light emission portion 18 toward the emission direction Lout. As described above, the laser light emission portion 18 may be the optical emission surface of the optical fiber 17.

[0085] Furthermore, the optical fiber 17 shown in Figure 5 is positioned on the outside of the hollow portion 21 of the rotational transmission member 20, rather than inside. Therefore, it becomes easier to reduce the diameter of the rotational transmission member 20 compared to the case where the optical fiber 17 is inserted through the hollow portion 21 of the rotational transmission member 20. Consequently, it also becomes easier to reduce the overall diameter of the light irradiation device 26. Moreover, since the overall diameter of the light irradiation device 26 can be reduced, it becomes easier to adjust the flexibility of the light irradiation device 26 (i.e., flexibility in the direction intersecting the extension direction of the device). Consequently, insertion and manipulation of the light irradiation device 26 into a living organism becomes easier. In addition, the manufacturing of the light irradiation device 26 becomes easier compared to the case where the optical fiber 17 is positioned in the hollow portion 21 of the rotational transmission member 20.

[0086] Furthermore, in the example shown in Figure 5, the optical fiber 17 is positioned inside the output direction marker portion 32. Therefore, since there is no need to devise a shape to position the optical fiber 17 outside the output direction marker portion 32, the configuration of the light irradiation device 26 can be easily simplified.

[0087] It is also possible to use only a portion of the configurations illustrated in the above embodiments and modifications in a light irradiation system, light irradiation device, or catheter. For example, as mentioned above, it is also possible to use only the light irradiation devices 2, 25, and 26 independently without using the catheter 3. It is also possible to manufacture the light irradiation devices 2, 25, and 26 by omitting at least one of the light sensor 41 and the temperature sensor 42. At least one of the light sensor 41 and the temperature sensor 42 may be provided on the proximal end side of the emission direction marker portion 32, or on the tip side of the emission direction marker portion 32. Furthermore, in the above embodiment, the light irradiation device 2 is covered up to the tip by the sealing member 16. However, it is also possible to manufacture the light irradiation device 2 without covering at least a portion of the light irradiation device 2 (for example, the tip portion including the laser light source 10 and the marker portion 30, etc.) with the sealing member 16.

[0088] Furthermore, it is possible to modify at least a part of the configuration exemplified in the above embodiments and modifications. For example, as mentioned above, the longitudinal axis marker portion 31 and the ejection direction marker portion 32 can be separate members. In this case, the longitudinal axis marker portion 31 and the ejection direction marker portion 32 may each be connected separately to the rotation transmission member 20. For example, the longitudinal axis marker portion 31 can be connected to the outside of the rotation transmission member 20, and the ejection direction marker portion 32 can be connected to the inside of the hollow portion 21 of the rotation transmission member 20. Also, regardless of whether the longitudinal axis marker portion 31 and the ejection direction marker portion 32 are integrated or not, it is also possible to connect the longitudinal axis marker portion 31 to the inside of the hollow portion 21 of the rotation transmission member 20.

[0089] Figure 6 is a perspective view of the vicinity of the tip of the light irradiation device 27 of the third modified example. The light irradiation device 27 of the third modified example differs from the embodiment described above in that it comprises a plurality of laser light emitting units (laser light sources) arranged spaced apart in the longitudinal direction.

[0090] As shown in Figure 6, the light irradiation device 27 comprises a first laser light source 10A and a second laser light source 10B. The first laser light source 10A is located at the tip of the light irradiation device 2. The second laser light source 10B is located closer to the base end than the first laser light source 10A. The emission direction marker portion 32 is located between the first laser light source 10A and the second laser light source 10B. The long axis marker portion 31 extends in the long axis direction so as to span the first laser light source 10A, the emission direction marker portion 32, and the second laser light source 10B. In the example of Figure 6, the long axis marker portion 31 is provided so as to connect each of these components. According to the light irradiation device 27 shown in Figure 6, the rigid emission direction marker portion 32 is located between the first laser light source 10A and the second laser light source 10B, rather than at the very tip of the light irradiation device 27. As a result, the possibility of the light irradiation device 27 getting caught inside the insertion site when it is inserted into the insertion site is appropriately reduced.

[0091] Furthermore, by positioning the emission direction marker 32 between the first laser light source 10A and the second laser light source 10B, the distance between each laser light source 10A, 10B and the emission direction marker 32 is shortened. As a result, medical professionals can accurately determine the positions of the two laser light sources immediately before and after the emission direction marker 32, as well as the emission direction of the laser light, by confirming the position of the emission direction marker 32 on the radiographic image. In other words, in a light irradiation device 27 equipped with multiple laser light sources 10A, 10B, both smooth insertion and ease of understanding (visibility) of the irradiation position can be achieved.

[0092] As shown in this modified example, by providing multiple laser light sources 10A and 10B at the tip of the light irradiation device 27, the degree of freedom in laser irradiation is improved compared to the case where only one laser light source is provided. Specifically, it becomes easier to adjust at least one of the following: the laser irradiation area, irradiation density, and irradiation direction. As a result, it becomes easier to obtain an appropriate therapeutic effect according to the condition of the affected area. In this case, the control unit 5 may be able to control the emission of laser light from at least some of the multiple laser light sources 10A and 10B independently of the other laser light sources. In this case, the degree of freedom in laser irradiation is further improved. For example, the control unit 5 may adjust the number of laser light sources that emit laser light. For example, it may be possible to select to light both or only one. This may change the laser irradiation area or irradiation density. The control unit 5 may also switch the laser light sources that emit laser light. This may change the area to which the laser light is irradiated without moving the light irradiation device 27. Furthermore, the laser light source emitting the laser beam may be switched not for the purpose of changing the area to which the laser beam is irradiated, but to extend the continuous irradiation time of the laser beam.

[0093] Furthermore, the first laser light source 10A and the second laser light source 10B may emit laser light in the same wavelength range. In this case, laser light in the same wavelength range can be irradiated to a specific area with a greater degree of freedom. For example, treatment can be performed by simultaneously irradiating a wide area of ​​lesions or by appropriately adjusting the irradiation density. As a result, it becomes easier to obtain an appropriate therapeutic effect.

[0094] At least a portion of the first laser light source 10A and the second laser light source 10B may include a laser light source that emits laser light in a wavelength range different from that of the other laser light sources. In this case, for example, laser light in different wavelength ranges can be selectively irradiated (for example, depending on the depth of the lesion or the type of drug used). Alternatively, laser light in different wavelength ranges may be irradiated simultaneously to act on biological tissue.

[0095] The technology relating to this disclosure can also be expressed as follows: (1) A light irradiation device for medical use that is elongated in shape, comprising: a rotation transmission member having an elongated external shape and transmitting rotation between a base end and a tip end; a laser light emission part provided at the tip end of the light irradiation device and emitting laser light in an emission direction intersecting the long axis direction of the light irradiation device, outside the light irradiation direction; and a marker part connected to the rotation transmission member at the tip end of the light irradiation device and having rigidity and radiopaqueness, wherein the marker part comprises: a long axis marker part extending along the long axis direction; and an emission direction marker part protruding from the long axis marker part in a direction parallel to the emission direction when the light irradiation device is viewed from a direction along the long axis direction, wherein the emission direction marker part is located closer to the base end than the tip end of the long axis marker part. (2) The light irradiation device according to (1), wherein the emission direction marker part is located closer to the base end than the laser light emission part. (3) A light irradiation device according to (1) or (2), characterized in that the emission direction marker portion is provided at a position further toward the tip from the tip end of the rotation transmission member. (4) A light irradiation device according to any one of (1) to (3), characterized in that the emission direction marker portion is a member surrounding the central axis of the light irradiation device, or a pair of members arranged opposite each other with the central axis in between. (5) A light irradiation device according to (4), further comprising a laser light source provided at the tip of the light irradiation device for emitting laser light, wherein the rotation transmission member is a hollow member, and the hollow portion of the rotation transmission member becomes a coolant flow path for passing a coolant that cools the laser light source from the base end to the laser light source.(6) A light irradiation device according to (4) or (5), comprising: a laser light source provided at the tip of the light irradiation device for emitting laser light; and a conductor extending from the base end to the tip along the rotation transmission member and electrically connected to the laser light source, wherein the conductor is arranged inside the emission direction marker portion. (7) A light irradiation device according to any one of (1) to (6), wherein the laser light emission portion is fixed directly or indirectly to the rigid marker portion. (8) A light irradiation device according to any one of (1) to (7), wherein at least the area around the tip is covered with a flexible sealing member, wherein at least the portion of the sealing member located in the path of the laser light is made of a material that transmits laser light. (9) A light irradiation device according to any one of (1) to (8), wherein a plurality of laser light emission units are provided at the tip of the light irradiation device, spaced apart in the longitudinal direction, and the emission direction marker unit is located between the plurality of laser light emission units. (10) A light irradiation system for medical use, comprising: a catheter formed in the shape of a long tube; and a long light irradiation device inserted into the lumen of the catheter, wherein the light irradiation device has a long outer shape and includes a rotation transmission member that transmits rotation between its proximal end and tip end; a laser light emission section provided at the tip of the light irradiation device that emits laser light in an emission direction intersecting the long axis of the light irradiation device, outside the light irradiation direction; and a marker section connected to the rotation transmission member at the tip of the light irradiation device and having rigidity and radiopaqueness, wherein the marker section includes a long axis marker section extending along the long axis; and an emission direction marker section that protrudes from the long axis marker section in a direction parallel to the emission direction when the light irradiation device is viewed from a direction along the long axis, wherein the emission direction marker section is located closer to the proximal end than the furthest tip of the long axis marker section.(11) A light irradiation system according to (10), characterized in that at least a part of the tip of the catheter has an outlet formed therein for discharging a cooling liquid from the inside of the catheter to the outside.

[0096] 1. Light irradiation system 2, 25, 26, 27. Light irradiation device 3. Catheter 10, 10A, 10B. Laser light source 11. Laser light emission section 17. Optical fiber 18. Laser light emission section 20. Rotation transmission member 21. Hollow section 30. Marker section 31. Long axis marker section 32, 33. Emission direction marker section 41. Optical sensor 42. Temperature sensor

Claims

1. A medical light irradiation device having an elongated shape, comprising: a rotation transmission member having an elongated external shape and transmitting rotation between a base end and a tip end; a laser light emission part provided at the tip end of the light irradiation device and emitting laser light in an emission direction intersecting the long axis direction of the light irradiation device, outside the light irradiation direction; and a marker part connected to the rotation transmission member at the tip end of the light irradiation device and having rigidity and radiopaqueness, wherein the marker part comprises: a long axis marker part extending along the long axis direction; and an emission direction marker part protruding from the long axis marker part in a direction parallel to the emission direction when the light irradiation device is viewed from a direction along the long axis direction, wherein the emission direction marker part is located closer to the base end than the furthest tip of the long axis marker part.

2. A light irradiation device according to claim 1, characterized in that the emission direction marker portion is located on the proximal end side of the laser light emission portion.

3. A light irradiation device according to claim 1, characterized in that the emission direction marker portion is provided at a position further away from the tip end of the rotation transmission member.

4. A light irradiation device according to claim 1, characterized in that the emission direction marker portion is a member surrounding the central axis of the light irradiation device, or a pair of members arranged opposite each other with the central axis in between.

5. A light irradiation device according to claim 4, further comprising a laser light source provided at the tip of the light irradiation device for emitting laser light, wherein the rotation transmission member is a hollow member, and the hollow portion of the rotation transmission member serves as a coolant flow path for passing a coolant for cooling the laser light source from the base end side to the laser light source side.

6. A light irradiation device according to claim 4, comprising: a laser light source provided at the tip of the light irradiation device for emitting laser light; and a conductor extending along the rotation transmission member from the base end to the tip end and electrically connected to the laser light source, wherein the conductor is arranged inside the emission direction marker portion.

7. A light irradiation device according to claim 1, characterized in that the laser light emitting portion is directly or indirectly fixed to the rigid marker portion.

8. A light irradiation device according to claim 1, wherein at least the area around the tip is covered with a flexible sealing member, and at least the portion of the sealing member located in the path of the laser light is made of a material that transmits laser light.

9. A light irradiation device according to claim 1, wherein a plurality of laser light emission units are provided at the tip of the light irradiation device, spaced apart in the longitudinal direction, and the emission direction marker unit is located between the plurality of laser light emission units.

10. A medical light irradiation system comprising: a catheter formed in the shape of a long tube; and a long light irradiation device inserted into the lumen of the catheter, wherein the light irradiation device has a long outer shape and includes a rotation transmission member that transmits rotation between its proximal end and tip end; a laser light emission section provided at the tip of the light irradiation device that emits laser light in an emission direction intersecting the long axis of the light irradiation device, outside the light irradiation direction; and a marker section connected to the rotation transmission member at the tip of the light irradiation device and having rigidity and radiopaqueness, wherein the marker section includes a long axis marker section extending along the long axis; and an emission direction marker section that protrudes from the long axis marker section in a direction parallel to the emission direction when the light irradiation device is viewed from a direction along the long axis, wherein the emission direction marker section is located closer to the proximal end than the furthest tip of the long axis marker section.

11. A light irradiation system according to claim 10, characterized in that at least a portion of the tip of the catheter has an outlet formed therein for discharging a cooling liquid from the inside of the catheter to the outside.

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