Inhibitors of PTPN2 / PTPN1 tyrosine phosphatase
Novel compounds targeting PTPN2 and PTPN1 provide effective inhibition, addressing limitations of existing therapeutics by enhancing cancer and metabolic disease treatment efficacy with reduced side effects.
WO2026132148A1PCT designated stage Publication Date: 2026-06-25KATHOLIEKE UNIV LEUVEN +1
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- KATHOLIEKE UNIV LEUVEN
- Filing Date
- 2025-12-18
- Publication Date
- 2026-06-25
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Abstract
The present invention relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of PTPN2 and / or PTPN1, yet more in particular for the prevention or treatment of cancer or metabolic diseases. The present invention also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds as well as to said compositions or preparations for use as a medicine, more preferably for the prevention or treatment of diseases mediated by activity of PTPN2 and / or PTPN1, yet more in particular for the prevention or treatment of cancer or metabolic diseases. The present invention also relates to processes for the preparation of said compounds.
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