A packaging system and packaging method for dental implants

Abstract

The invention relates to a packaging system comprising an enclosure made of glass for protecting dental implants from external influences and a protective layer for protecting the enclosure from contact damage, and a method for packaging said dental implant with the glass enclosure.

Description

[0001] DESCRIPTION

[0002] A PACKAGING SYSTEM AND PACKAGING METHOD FOR DENTAL IMPLANTS

[0003] Technical Field of the Invention

[0004] The invention relates to a packaging system comprising an enclosure made of glass for protecting dental implants from external influences and a protective layer for protecting the enclosure from contact damage, and a method for packaging said dental implant with the glass enclosure.

[0005] State of the Art of the Invention

[0006] Dental implants have been used to replace complete or partial tooth loss since their invention by Per Ingvar Branemark. Although they can be manufactured from different materials (e.g. peek, ceramic, zirconia, tantalum), the most preferred material is titanium and titanium alloys. The surfaces of the first implants manufactured were machined. Over time, many studies have been performed to modify the surface chemistry and topography to improve osseointegration properties. There were 2 known methods applied to improve the osseointegration properties: a) Additive Techniques: TPS (Titanium Plasma Spray), Hydroxyapatite coating b) Subtractive Technique: Sandblasting with different media (A12O3, TiO2, CaO) and acid etching (using different acids, process times, and temperatures)

[0007] Today, the majority of dental implant manufacturers use implant material surfaces that have been roughened with the help of subtractive techniques. Titanium, which is used as a dental implant material, is resistant to corrosion thanks to the naturally occurring TiO2 layer on its surface, is bio-compatible, and has a load-bearing capacity due to osseointegration. It can establish a structural and functional bond between the surface of the implant and the surrounding bone tissue without forming fibrous tissues. Titanium

[0008] Researchers have been studying implant biomaterials for decades, discovering and developing optimal biocompatible materials that can be used as implants and provide high levels of osseointegration and durability. Compared to other metallic biomaterials, pure titanium and alloys thereof show extremely high mechanical strength, low coefficient of elasticity, high fatigue strength and corrosion resistance, and are highly biocompatible. Thanks to its superior mechanical and physicochemical properties, titanium stands out among all materials, including stainless steel, in cases where biocompatibility and clinical preference is of concern.

[0009] Titanium aging

[0010] Biological aging can be defined as the physiochemical degradation of the implant surface over time. A titanium implant is considered to have insufficient osseointegration if, after an appropriate healing period, the bone-implant contact remains below 100%. This is associated with the inevitable buildup of carbon, which results in the attachment of airborne hydrocarbons to the titanium implant surface. This results in reduced hydrophilicity and loss of surface charge. Ultimately, physiochemical and biological properties are impaired. For example, osteoconductivity is reduced, osteogenic activity is attenuated, and the absorption of serum proteins is reduced.

[0011] Osseointegration

[0012] According to Branemark's observations in the 1950s, titanium implanted in a rabbit bone integrates perfectly with the bone and cannot be removed without breaking the bone. Another discovery Branemark made after this was that titanium can be tolerated by the human body and slowly integrate with the host bone structure; this phenomenon was called "osseointegration".

[0013] Osseointegration (OI) can be defined as the direct structural and functional bond between the host hard tissue and the load-bearing implant surface at the histologic level. In the case of bone augmentation, which does not require any soft tissue intervention between the bone and the implant interface, the implants are fixed to the host tissue with permanent durability and hardness. Osseointegration is essential for the primary durability of implants. It is therefore a very important factor to be taken into account before subsequent treatments.

[0014] Osseointegration mechanism

[0015] During osseointegration (01), bone formation develops through bonding, settling, spreading of young bone cells, and their subsequent maturation. In the next stage, mineralization occurs around the released proteins. Many biological events identical to bone healing occur around the bone-implant interface.

[0016] The healing process starts within a few seconds as soon as the blood comes into contact with the surface of the implant. Clotting cascades are initiated by platelets. Subsequently, phagocytic cells also migrate to the damaged area.

[0017] In the first few days after implant surgery, neutrophils are maximized in number to remove dead cells and bacterial debris. Macrophages accompany the degradation process, releasing more cytokines and attracting osteogenic and endothelial precursors into the healing environment. At the same time, angiogenesis occurs within the fibrin network as clots are removed. The fibrin network acts as a scaffold for the colonization of young bone cells and mesenchymal stem cells (MSCs) in the first few days.

[0018] When precursor bone cells arrive, the formation of the network and the continuation of mineralization are initiated through contact bone formation. In the second week, the knitted bone tissue begins to remodel on the implant surface and is replaced by a layered mature bone over the next three months.

[0019] Hydrophilicity

[0020] Hydrophilicity can be defined as the ability of surfaces to be wetted by aqueous solutions. When a water droplet falls on a hydrophobic surface, the shape of the droplet is maintained; when it falls on a hydrophilic surface, the droplet spreads. The angle between the solid surface and the tangent line of the liquid phase at the interface of solid-liquid phases is called the contact angle. When the contact angle is less than 5 degrees, the surface is called "hydrophilic". When the contact angle approaches 0 degrees, the water completely wets the surface and this is called super hydrophilicity. However, according to previous studies in the literature, regardless of surface topography and surface modification technique, the deterioration of the osteoconductivity of a titanium surface over time leads to a loss in the biomechanical strength of Bone Implant Contact (BIC) compared to a freshly prepared titanium surface. Due to the gas-permeable packaging of conventional titanium implants, hydrocarbons that penetrate the environment accumulate on the implant surfaces within 4 weeks, turning hydrophilic surfaces into hydrophobic surfaces.

[0021] Studies have shown that aging of the titanium surface causes a decrease in the binding of serum proteins to the implant surface and a decrease in osteogenic cell activity due to the accumulation of hydrocarbons in the air on the implant surfaces. As the amount of hydrocarbons increases, the zeta potential of the titanium surface changes from electropositive to electronegativity, thus preventing the adhesion of negatively charged blood protein and extracellular matrix to the surface. As the titanium surface ages over time, hydrophobicity increases significantly and the contact angle increases to over 40 degrees at 2 weeks of aging and over 60 degrees at 4 weeks of aging.

[0022] 1. Polymer Type

[0023] The gas permeability of polymer-based packaging is an important factor, especially in the protection of food, pharmaceutical, medical, and other sensitive products. The gas permeability properties of polymers can affect the shelf life of the packaging product, as the passage of gases such as oxygen, water vapor, carbon dioxide can lead to deterioration or drying of the contents. The gas permeability of polymer-based packaging varies depending on several factors:

[0024] Different types of polymers permeate gases to different degrees. In general, polymers have less gas permeability with polyaromatic structures and regular structures. For Example:

[0025] Different types of polymers permeate gases to different degrees. In general, polymers are polyaromatic structures and have less gas permeability with regular structures. For Example:

[0026] • Polyethylene (PE): It is known for its low gas permeability, but does not completely block the passage of gases such as oxygen and carbon dioxide. • Polypropylene (PP): It has a slightly higher gas permeability than PE.

[0027] • Polyvinyl chloride (PVC): Gas permeability is higher than PE and PP.

[0028] • Nylon (PA): It can be highly permeable, especially to the passage of oxygen, so it is often used for high-performance packaging.

[0029] • Ethylene- vinyl alcohol (EVOH): It shows very low permeability to oxygen transmission and is therefore widely used, especially in oxygen barrier packaging.

[0030] • Polyethylene terephthalate (PET): It provides a good barrier against the passage of oxygen and carbon dioxide, but has a higher water vapor permeability.

[0031] 2. Polymer Structure

[0032] • Crystalline and Amorphous Structures: Crystalline polymers generally have lower gas permeability, while amorphous structures are more permeable. For example, polyethylene with high crystallinity has low gas permeability, while polystyrene, like amorphous structures, is more permeable.

[0033] • Amount and Thickness of Polymer: As the thickness increases, the passage of gases becomes more difficult. But this can also affect the cost and durability of the packaging.

[0034] 3. Gas Type

[0035] Different gases pass through different polymers at different speeds. While oxygen generally passes through polymers more easily, the passage of carbon dioxide and water vapor varies depending on the structure and properties of the polymer.

[0036] • Oxygen: Most polymers have high oxygen permeability, therefore oxygen barrier materials are preferred to limit the passage of oxygen in food packaging.

[0037] • Water Vapor: The permeability of polymers to water vapor is often different from the permeability to oxygen. Differences between polymers can affect the rate at which water vapor passes through the package. 4. Environmental Factors

[0038] • Temperature and Humidity: As the temperature increases, the gas permeability of polymers can increase. In addition, the humidity level of the environment can also affect the permeability properties of the polymer. High humidity can increase permeability in some polymers.

[0039] 5. Application Areas

[0040] • Pharmaceutical Products: Medicines are also products that generally need to be protected from oxygen and moisture, therefore materials with low gas permeability are used.

[0041] • Medical Applications: The gas permeability of packaging for medical devices and products can be critical for maintaining sterility.

[0042] 6. Test Methods

[0043] Several test methods are used to determine gas permeability:

[0044] • Manometric Test: It is a method for measuring the rate at which gas passes through a polymer film.

[0045] • Volumetric Method: It measures the volume of gas passing through a polymer surface over a given period of time.

[0046] • Measurement with Waves: It is used especially for oxygen permeability.

[0047] The gas permeability of polymer-based packaging varies depending on the type of polymer used, its structure, thickness, and environmental conditions. The selection of suitable polymers and barrier properties for protecting the product targeted by the packaging is crucial for the success of the packaging. Polymers with barrier properties, especially against external factors such as oxygen and moisture, are widely used in the food and pharmaceutical industries. Document with publication no. US5755575A describes a packaging method for sterile and contamination-free storage of implants. Here, the implant is positioned in a sealable capsule made of the same material as the implant and then the capsule is placed in a hermetically sealable outer enclosure. By hermetically sealing said outer enclosure, the package thus obtained is sterilized.

[0048] Although these solutions protect dental implants against hydrocarbon contamination, they pose major problems during their transportation. These implants are used in doctors' offices, not where they are manufactured. Therefore, every product is transported from one place to another at least once. Glass-based products often break and become contaminated during this type of transportation, and as a result, their sterilization is compromised, making them unsuitable for use on patients.

[0049] As a result, all the above-mentioned problems have made it imperative to make an innovation in the relevant field.

[0050] Objects of the Invention

[0051] The main object of the invention is to prevent hydrocarbon contamination or reduce the contamination rate of dental implants throughout their shelf life.

[0052] The main object of the invention is to provide a dental packaging system structure suitable for transportation while providing protection against hydrocarbon contamination.

[0053] The object of the invention is to increase the healing process and quality of the implant by maintaining the surface activity and surface cleanliness of the implant when it is first produced.

[0054] Descriptions of the Drawings Describing the Invention

[0055] The figures and the related descriptions used in order to better describe the device designed with this invention are as follows.

[0056] Fig- 1- Cross-sectional view of the packaging system subject to the invention Fig. la. Exploded image of the packaging system subject to the invention

[0057] Fig. 2. Exploded image of the packaging system subject to the invention Fig. 2a. Exploded image of the packaging system subject to the invention.

[0058] Definitions of the Elements / Features / Parts of the Invention

[0059] In order to better describe the device developed with this invention, the features and parts in the figures are numbered and the equivalent of each number is given below.

[0060] 10. Enclosure

[0061] 11. Lower body

[0062] 12. Upper body

[0063] 13. Intermediate portion

[0064] 20. Dental implant

[0065] 21. Implant fixture

[0066] 22. Retainer

[0067] 23. Implant carrier screw

[0068] 24. Implant carrier

[0069] 25. Implant carrier tip

[0070] 26. Retainer slot

[0071] 27. Cap

[0072] 30. Tube

[0073] 40. Protective layer

[0074] V. Closed volume

[0075] Detailed Description of the Invention

[0076] The subject of the invention relates to a packaging system comprising an enclosure made of glass for protecting dental implants and a method for packaging the dental implant with the glass enclosure.

[0077] The present invention discloses a packaging system comprising a dental implant (20) contained in a glass enclosure (10). The present glass enclosure (10) forms a closed volume (V) that completely cuts off the dental implant (20) from contact with the external environment. As a result, despite the applications of the present art, gas permeability is reduced to a negligible amount or completely eliminated.

[0078] It is important for gas permeability that the glass enclosure (10) is monolithic. The definition of monolithic here refers to glass structures that are provided completely in one piece or joined to each other as monolithic. The definition of monolithic here indicates that there are no caps or similar removable elements to form the enclosed volume (V).

[0079] The present enclosure (10) describes the construction of ampoules made of inorganic oxide glass that are fully insulated from the outside for the long-term storage of dental implants (20).

[0080] In the preferred embodiment of the invention, the glass is described as being a silicate-based glass, and in the even more preferred embodiment of the invention, said glass is described as being sodium silicate glass. The material used may be any of the following families: quartz glass, soda lime silicate glass, borosilicate glass, neutral borosilicate glass, aluminosilicate glasses, or aluminoborosilicate glass compositions from the silicate glass family.

[0081] By applying a thin film barrier layer as a coating on the inner and / or outer wall of the capsule, it may be possible to reduce gas permeability and increase long-term chemical resistance. Accordingly, layers of AI2O3, ZrCh, SiCh, SnCh, TiCh, SiOxCy, SiOxNy or SiOxCyNz composition that exhibit optical thin film properties can be coated by chemical vapor deposition or physical vapor deposition method. To achieve higher barrier properties, multiple materials selected from the examples herein, preferably AI2O3, TiCh, AI2O3, TiCh or derivatives thereof, can be alternately coated to form multilayer thin film structures and epitaxial coatings can be obtained by atomic layer deposition technique with atom-level control. In addition, OLED encapsulation, thin film encapsulation techniques can also be used to coat said enclosure (10).

[0082] In addition, plastic films coated with thin films of metals such as aluminum can also be coated on top of the outer wall of the glass enclosure.

[0083] In an embodiment of the invention, a protective layer (40) of flexible material wraps at least around the circumference of the dental implant (20). Accordingly, a protective layer (40) made of a resilient material surrounds at least the circumference of the dental implant (20) to prevent fracture and / or cracking by absorbing most of the impacts of the dental implant (20) on the glass enclosure (10).

[0084] In an embodiment of the invention, there is at least one attenuation zone. Here, the attenuation zone refers to a region with lower strength than the rest of the glass enclosure (10) and allows the glass enclosure (10) to be easily broken open from the relevant region. The attenuation zone can be achieved by notch cutting or single point cutting of the glass enclosure (10).

[0085] With reference to figs. 1 and la; the glass enclosure (10) is preferably in the form of an ampoule, however this geometrical choice should not be interpreted as a restrictive requirement. Any form that can provide a closed volume (V) in which the dental implant (20) can be placed is suitable for use in the invention. For example, a prismatic structure can also be used as an enclosure (10) as long as it is made of glass.

[0086] Here, dental implant (20) refers to at least one dental implant fixture (21).

[0087] In a preferred embodiment, the dental implant (20) comprises a tube (30). This tube (30) has a cylindrical form and wraps around at least the implant fixture (21). The tube (30) is preferably made of metal, especially titanium. Here, the cylindrical shape of the tube (30) also helps the dental implant (20) to sit securely in the base of the enclosure. In addition, preferably the diameter of the tube is arranged so that it is very close to the diameter of the enclosure (10), thereby minimizing the possibility of movement of the tube (30) and the implant (20) within the enclosure (10). Preferably, the diameter of the area of the enclosure (10) closest to the tube (30) is selected to be 1-2% larger than the diameter of the tube (30). For example, the diameter of the tube (30) is 6 mm, while the diameter of the closest part of the enclosure (10) to the tube (30) is 6.1 mm. The tube (30) can preferably be closed with a cap (27).

[0088] This protective layer (40) is positioned to surround the dental implant (20) or tube (30), if present. Here, the protective layer (40) can absorb impacts, which may occur in certain areas, by surrounding at least part of the dental implant (20). Preferably, the protective layer is arranged to cover the lateral surface of the dental implant (20), for example the entire lateral surface of the tube (30). For example, a protection layer (40) in cylindrical form can be used here. In the most preferred embodiment, the protective layer (40) is arranged to completely surround said dental implant. It is of great importance that the protective layer (40) is made of flexible material for impact damping. Accordingly, the protective layer (40) may preferably be made of any polymer, elastomer, rubber derivative, composite material, elastic textile, and gel-based material that exhibits elastic behavior. In addition, the material selection of the protective layer (40) is done with a group comprising thermoplastic elastomer, thermoplastic polyurethane, silicone elastomer, natural rubber, nitrile rubber, chloroprene rubber, ethylene-propylene-diene rubber, styrene-butadiene rubber, flexible polyvinyl chloride, low-density polyethylene, flexible polypropylene, elastomer-added composite polymer, elastic textile material, silicone-coated fabric, hydrogel, or polyurethane gel.

[0089] The protective layer (40) can be positioned freely, i.e., unstretched, around said implant. However, in the preferred embodiment, the protective layer (40) is stretched over the dental implant (20) in a stretched form, thereby providing surface-to-surface contact and enhancing protection.

[0090] Another important parameter is the wall thickness of the protective layer (40). The wall thickness of the protective layer (40) is selected according to the distance between the dental implant (20) and the glass enclosure and the expected impact absorption performance of the protective layer (40) (the type of material is also important here). Studies have shown that the wall thickness in the free state (unstretched state) should be between 0.2-1.2 mm. Although different wall thicknesses are possible, the optimum values are in the range mentioned here.

[0091] In order to determine the effectiveness of the protective layer (40), two different packaging assemblies were subjected to the following tests respectively.

[0092] 1. ASTM D4169-23el : Standard Practice for Performance Testing of Shipping Containers and Systems.

[0093] 2. ASTM D642-20: Standard Test Method for Determining Compressive Resistance of Shipping Containers, Components, and Unit Loads.

[0094] 3. ASTM D6653 / D6653M -13(2021): Standard Test Methods for Determining the Effects of High Altitude on Packaging Systems by Vacuum Method.

[0095] 4. ASTM D5276-19 (2023): Standard Test Method for Drop Test of Loaded Containers by Free Fall. 5. ASTM D999-08 (2023): Standard Test Methods for Vibration Testing of Shipping Containers.

[0096] The first group does not have said protective layer (40) in any way. Said group was subjected to testing in a parcel. In the first group, there were a total of 37 ampoule-shaped enclosures (10). The glass enclosure (10) samples were examined for damage after the transportation tests. As a result of the visual inspection, 18 of the glass ampoules were observed to be broken.

[0097] In the second group, all packaging systems contain a protective layer (40). In the second group, a total of 33 glass enclosure samples (10) provided in ampoule form were examined for damage after the transportation tests. Upon visual inspection, it was observed that none of the glass ampoules were broken or damaged.

[0098] Accordingly, the structure in which the protective layer (40) is provided proves its effectiveness in terms of ensuring safety during transportation.

[0099] With reference to Fig. 2 and 2a; here, the implant fixture (21) is a cylindrical structure that is inserted into the jawbone and is appropriately threaded around the outer circumference. The implant carrier (24) also has a cylindrical structure and is sized to fit inside the fixture. Here, the implant carrier screw (23) enters through the top of the implant carrier (24) and fixes the parts together.

[0100] In an embodiment of the invention, said implant fixture (21) comprises a female slot. The implant carrier tip (25) for said female slot is arranged as a male tip. The implant carrier tip (25) is inserted into this slot. The implant carrier (24) has a channel on the inside. The implant carrier screw (23) passes through this channel and the implant carrier screw (23) screws the implant carrier (24) into the implant fixture (21). The implant carrier tip (25) has a retainer slot (26). The retainer slot (26) is preferably arranged as a circumferential channel on the implant carrier (24). Said retainer (22) has an opening in the center and flexible flaps around this opening. With the help of the opening, the retainer (22) is passed through the implant carrier (24) and inserted into the retainer slot (26). The assembled dental implant (20) is then inserted into the tube (30). Here, the dental fixture (21) remains in a suspended position without contacting the enclosure (10) and the tube (30). To ensure this, the retainer (22) is also placed inside the tube (30). When the flaps of the said retainer (22) are inserted into the tube (30), its flaps, which tend to open, hold the implant carrier (24) and thus the implant fixture (21) in a suspended position.

[0101] In an embodiment of the invention, the dental implant (20) is made of titanium. Alternatively, it is possible to use a dental implant (20) made of PEEK, tantalum, zirconia, or ceramic.

[0102] Furthermore, said dental implant (20) may be stored in the enclosure (10) in assembled form as described above, or its parts may be stored separately, however, keeping it in assembled form makes it possible to use the volume of the enclosure (10) more efficiently.

[0103] The ampoule-shaped structure also contains a lower body (11) in cylindrical form, preferably forming the base. An upper body (12) at the top part of said lower body (11) having a diameter narrower than said lower body (11), and an intermediate portion (13) connecting said lower body (11) and upper body (23) and having a diameter narrower than said upper body (12) are provided. The upper body (12) is completely closed at the end. The upper body (12) can be arranged as partially cylindrical.

[0104] In embodiments including an attenuation portion, the attenuation portion may be provided circumferentially on the intermediate portion (13).

[0105] In an embodiment of the invention, wherein the enclosure (10) is provided in the form of an ampoule, the size of the tube (30) is arranged so that it is above the intermediate portion (13). The length of the tube in which the implant fixture (21) is placed is sized so that it remains above the attenuation portion. In this way, the possible microscopic glass particles formed when the enclosure (10) is broken will not reach the entrance of the tube (30) and therefore will not contact the implant fixture (21). The present embodiment prevents potential health problems that may arise during and after implantation and microscopic glass particles that may remain on the implant fixture (21).

[0106] Here, preferably the implant fixture (21) partially extends into the lower body (11), while the retainer (22), the implant carrier screw, (23) and the implant carrier (24) extend into the upper body (12). In addition, as can be seen in Fig. 1 and la, the tops of the implant (20) and tube (30) can be sized to be below the intermediate portion (13). Here it is advantageous to size the dental implant (20) so that its length is below the attenuation portion. That is, if the attenuation portion is located below the tube (30), there is no clean fracture when the ampoule is broken on the end user side, which may cause harm to the user or complicate the operation. Accordingly, the arrangement of the length of the dental implant (20) to be below the attenuation portion as shown in Fig. la provides an advantage especially for the end user against potential hazards.

[0107] The present invention also relates to a method for producing said packaging system.

[0108] Here, a glass enclosure (10) having an opening is first provided. The dental implant (20) is inserted into the enclosure (10) through the opening in the glass enclosure (10). At this point, a closed volume is created in two different ways to protect the dental implant (20) from external influences. Here, before the dental implant (20) is placed in the glass enclosure (10), the protective layer (40) is placed around the dental implant or the protective layer (40) is stretched over it in a tensile state.

[0109] The tube drawing method can be used to create the closed volume. Here, the glass enclosure (10) is heated to the formable temperature. Preferably, flame heating or induction heating method can be selected for heating. Then it is pulled with a tube so that the opening closes while retaining its shape. The opening closes when the tube is withdrawn. Accordingly, the dental implant (20) remains in a closed volume (V) in the glass enclosure (10).

[0110] In another embodiment, the glass enclosure (10) is heated to a formable temperature and another heated piece of glass is inserted into the opening so that this piece closes the opening, thereby maintain the dental implant (20) in a closed volume (V).

[0111] Preferably, the volume (V) in the glass enclosure (10) can be filled with liquid or gas without closing said opening. Neon, krypton, radon, oxygen, helium, xenon, argon, or nitrogen can be used as gases and saline solution, saline solution derivatives, or deionized distilled water as liquids.

[0112] After said opening is closed, the present enclosure (10) is allowed to cool down. Here, a cold environment can be used, or the glass can be left to cool naturally.

Claims

AMENDED CLAIMS received by the International Bureau on 16 Jan. 2026 (16.01.2026)1. A packaging system, characterized in that it comprises: a dental implant (20) and an enclosure (10) made of monolithic glass, which forms a closed volume (V) completely enclosing said dental implant (20).

2. A packaging system according to claim 1, characterized in that it comprises at least one protective layer (40) made of flexible material positioned between the glass enclosure (10) and the dental implant (20).

3. A packaging system according to claim 2, characterized in that it comprises said protective layer (40) provided to completely surround at least the lateral surface of the dental implant (20).

4. A packaging system according to claim 2, characterized in that it comprises said protective layer (40) provided to completely surround the surface of the dental implant (20).

5. A packaging system according to any one of the preceding claims, characterized in that it comprises said protective layer (40) provided in surface-to-surface contact with the outer surface of the dental implant (20).

6. A packaging system according to any one of the preceding claims, characterized in that it comprises said protective layer (40) in a tensile state.

7. A packaging system according to any one of the preceding claims, characterized in that it comprises said protective layer (40) made of any polymer, elastomer, rubber derivative, composite material, elastic textile, gel-based material exhibiting elastic behavior.

8. A packaging system according to claim 7, characterized in that it comprises said protective layer (40) made of thermoplastic elastomer, thermoplastic polyurethane, silicone elastomer, natural rubber, nitrile rubber, chloroprene rubber, ethylene-propylene- diene rubber, styrene-butadiene rubber, flexible polyvinyl chloride, low-densitypolyethylene, flexible polypropylene, elastomer-added composite polymer, elastic textile material, silicone-coated fabric, hydrogel, or polyurethane gel.

9. A packaging system according to any one of the preceding claims, characterized in that it comprises said protective layer (40) having a wall thickness of 0.2-1.2 mm in a unstretched state.

10. A packaging system according to any one of the preceding claims, characterized in that it comprises a cylindrical tube (30) enclosing at least said implant (20).

11. A packaging system according to claim 10, characterized in that it comprises said tube (30) made of titanium.

12. A packaging system according to claim 1, characterized in that it comprises said enclosure (10) provided in a prismatic form.

13. A packaging system according to claim 1, characterized in that it comprises said enclosure (10) provided in an ampoule form.

14. A packaging system according to claim 1, characterized in that it comprises a cylindrical lower body (11), an upper body (12) at least partially provided in a cylindrical shape and having a diameter narrower than said lower body (11), and an intermediate portion (13) connecting said lower body (11) and upper body (12) and having a diameter narrower than said upper body (12).

15. A packaging system according to any one of the preceding claims, characterized in that it comprises an attenuation zone for breaking and opening the glass enclosure (10).

16. A packaging system according to claim 15, characterized in that it comprises the attenuation zone provided in the intermediate portion (13) for opening the glass enclosure (10).

17. A packaging system according to claim 15 or 16, characterized in that it comprises said dental implant (20) provided such that its length remains below the attenuation zone.

18. A packaging system according to claim 1, characterized in that it comprises said enclosure (10) made of inorganic oxide glass.

19. A packaging system according to claim 1, characterized in that it comprises said enclosure (10) made of a silicate-based glass, alkali silicate, sodium silicate glass, soda-lime silica glass, boron silicate glass, alumina silicate, phosphor silica, or quartz glass.

20. A packaging system according to claim 1, characterized in that it comprises gas provided in the closed volume (V).

21. A packaging system according to claim 20, characterized in that it comprises said gas selected from neon, krypton, radon, oxygen, helium, xenon, argon, or nitrogen.

22. A packaging system according to claim 1, characterized in that it comprises liquid provided in a closed volume (V).

23. A packaging system according to claim 22, characterized in that it comprises said liquid selected from saline solution, derivatives of saline solution, or deionized distilled water.

24. A packaging system according to claim 1, characterized in that said enclosure (10) comprises a coating to reduce or prevent gas permeability.

25. A packaging system according to claim 24, characterized in that said enclosure (10) comprises a thin film barrier layer as a coating on the inner and / or outer wall thereof.

26. A packaging system according to claim 24, characterized in that said enclosure (10) comprises film layers with a content of AI2O3, ZrCb, SiCh, SnCh, TiCh, SiOxCy, SiOxNy or SiOxCyNz.

27. A packaging system according to claim 24, characterized in that said enclosure (10) comprises a coating in the form of metal-film-coated plastic films.

28. A packaging system according to any one of claims 24-27, characterized in that said enclosure (10) comprises a multilayer coating.

29. A production method for a packaging system according to any one of the preceding claims, characterized by:Surrounding at least part of the circumference of the dental implant (20) with a protective layer (40) made of elastic material,Placing the dental implant (20) in an enclosure (10) made of glass having at least one opening,Applying enough heat to the glass enclosure (10) to make at least part of it formable, Shaping the formable part of the enclosure (10) so as to form a closed volume (V) by closing said opening, or inserting another piece of glass into said opening by heating so as to form a closed volume (V).

30. A method according to claim 29, characterized in that the heated enclosure (10) is shaped to form a closed volume (V) by tube drawing.

31. A method according to claim 29, characterized in that said opening portion is heated and said end of another piece of glass having an end corresponding to said opening portion is heated and the end and the opening are joined to form a volume (V).

32. A method according to claim 29, characterized in that the dental implant (20) is placed inside the enclosure (10) in a mounted state.

33. A method according to claim 29, characterized in that the dental implant (20) is placed inside the enclosure (10) in a disassembled state.

34. A method according to claim 29, characterized in that said enclosure (10) is filled with gas before the opening is closed.

35. A method according to claim 34, characterized in that said gas is neon, krypton, radon, oxygen, helium, xenon, argon, or nitrogen.

36. A method according to claim 29, characterized in that said enclosure (10) is filled with liquid before the opening is closed.

37. A method according to claim 36, characterized in that said liquid is a saline solution, saline solution derivatives, or deionized distilled water.

38. A method according to claim 29, characterized in that at least a part of said enclosure (10) is attenuated for an easy break.

39. A method according to claim 38, characterized in that said attenuation is provided by notched cutting or single point cutting.

40. A method according to claim 29, characterized in that the inner and / or outer wall of said enclosure (10) is coated.

41. A method according to claim 40, characterized in that said enclosure (10) is coated with layers having a composition of AI2O3, ZrCh, SiCh, SnCh, TiCh, SiOxCy, SiOxNy or SiOxCyNz.

42. A method according to claim 40 or 41, characterized in that said enclosure (10) is coated by chemical vapor deposition, physical vapor deposition methods, atomic layer deposition OLED encapsulation, and thin film encapsulation.

43. A method according to claim 40, characterized in that said enclosure (10) is coated with metal-film with coated plastic films.

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