Nitric oxide and chlorhexidine releasing catheter for anti-platelet and antimicrobial dual functionality

A nitric oxide and chlorhexidine impregnated catheter addresses the limitations of current catheters by providing sustained anti-platelet and antimicrobial functionality, effectively inhibiting platelet activation and eradicating biofilms.

AU2020387925B2Pending Publication Date: 2026-07-23BECTON DICKINSON & CO
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Patent Information

Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
BECTON DICKINSON & CO
Filing Date
2020-11-11
Publication Date
2026-07-23

AI Technical Summary

Technical Problem

Current catheters lack effective long-term antimicrobial and anti-platelet capabilities, leading to catheter-related bloodstream infections and thrombus formation, and existing anti-thrombogenic technologies are either ineffective or costly.

Method used

A catheter impregnated with a nitric oxide releasing compound and chlorhexidine, manufactured through a multi-step process involving impregnation and dip-coating, to provide simultaneous anti-platelet and antimicrobial properties.

Benefits of technology

The catheter effectively releases nitric oxide and chlorhexidine to inhibit platelet activation and eradicate biofilms, reducing infections and thrombus formation over an extended period.

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Abstract

A catheter configured to release nitric oxide and chlorhexidine providing anti-platelet and antimicrobial properties is manufactured by impregnating a thermoplastic polyurethane catheter extrusion with a nitric oxide releasing compound and with chlorhexidine. Thereafter, the impregnated catheter extrusion is coated with a polyurethane coating comprising chlorhexidine and / or a nitric oxide releasing compound. In the impregnating step, the catheter extrusion may be exposed to a solvent having the nitric oxide releasing compound and chlorhexidine dissolved therein. The solvent is removed from the catheter extrusion. In the coating step, the impregnated catheter extrusion may be dip coated in a polymer solution comprising polyurethane and chlorhexidine and / or a nitric oxide releasing compound in a suitable solvent. The nitric oxide releasing compound, impregnated and / or coated, may be selected from s-nitroso-n-acetylpenicillamine (SNAP), s-nitrosoglutathione (GSNO), and mixtures thereof. The chlorhexidine, impregnated and / or coated, may be selected from chlorhexidine diacetate, chlorhexidine base, chlorhexidine gluconate, and mixtures thereof.
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Citation Information

Patent Citations

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