Enantiomerically pure R-beta-hydroxybutyrate mixed salt-acid compositions

AU2021216437B2Pending Publication Date: 2026-07-09AXCESS GLOBAL SCIENCES LLC
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Patent Information

Application Number
AU2021216437
Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
Priority Date
2020-02-06
Filing Date
2021-02-08
Publication Date
2026-07-09
Estimated Expiration
2041-02-08

AI Technical Summary

Technical Problem

Transitioning into and sustaining a ketogenic state is challenging due to the difficulty of depleting glucose stores, physical and emotional demands, hypoglycemia, electrolyte imbalances, and negative effects such as muscle aches, spasms, and cognitive issues, and existing compositions like racemic beta-hydroxybutyrate mixtures are inefficient.

Method used

Enantiomerically pure R-beta-hydroxybutyrate mixed salt-acid compositions, combining R-beta-hydroxybutyrate salts with free R-beta-hydroxybutyric acid, provide a rapid absorption rate, optimized electrolyte load, and improved taste, facilitating easier formulation and reducing the need for additional acids to maintain ketosis.

Benefits of technology

The compositions effectively promote and sustain ketosis with reduced electrolyte load, faster absorption, and improved taste, offering benefits like appetite suppression, weight loss, improved cognitive function, and reduced metabolic side effects.

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Abstract

A ketogenic R-beta-hydroxybutyrate mixed salt-acid composition includes enantiomerically pure R-beta-hydroxybutyric acid and one or more enantiomerically pure R-beta-hydroxybutyrate salts. The R-beta-hydroxybutyric acid is more rapidly absorbed and utilized by the body than salts or esters, enhances taste, and reduces the need to include citric acid or other edible acids. The enantiomerically pure R-beta-hydroxybutyrate salt(s) are more slowly absorbed and utilized by the body and can provide one or more electrolytes. Compositions for increasing ketone body level in a subject may contain a dietetically or pharmaceutically acceptable carrier and an R-beta-hydroxybutyrate mixed salt-acid composition. The composition contains less than 100% by molar equivalents of total enantiomerically pure R-beta-hydroxybutyrate salts and more than 0% by molar equivalents of enantiomerically pure R-beta-hydroxybutyric acid.
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Citation Information

Patent Citations

  • Compositions comprising beta-hydroxybutyric acid and salt, and methods of using the same

    US20180021274A1