Turmeric and Creatine Compositions, Method for Preparing Them, and Use of Said Compositions as a Food Supplement

Description

1 / 20 “Turmeric and Creatine Compositions, Method for Preparing Them, as well as the Use of Said Compositions as a Food Supplement” Field of Invention

[0001] The present invention relates to a bioactive composition for dietary supplementation of creatine and turmeric in the recommended daily supplementation amounts and, optionally, additional bioactive ingredients.

[0002] The aforementioned composition is further prepared to maximize the stability and bioavailability of creatine and turmeric in solid and semi-solid presentation forms.

[0003] The present invention also relates to a substantially waterless process for manufacturing said composition and to its use as a food supplement for improving physical performance, as well as for recovery and maintenance of muscle health. Fundamentals of the Invention

[0004] The growing interest in health and physical performance has driven the adoption of dietary practices aimed at optimizing the performance of individuals who engage in physical exercise. One of these nutritional strategies is the use of dietary supplements to complement nutritional needs, facilitating adequate calorie intake and promoting the ideal balance of macronutrients and micronutrients essential for the body. However, despite the wide variety of supplements available on the market, many still fail to offer formulations that are properly balanced and contain ingredients capable of providing physiological benefits.

[0005] Creatine, for example, is widely recognized for its role in muscle energy metabolism and has been used to improve strength, increase muscle mass, and accelerate post-exercise recovery. Studies show that Petition 870240110444, dated 12 / 26 / 2024, page 11 / 36 2 / 20 Creatine supplementation can reduce fatigue, aid in the recovery of muscle injuries, and promote a cellular environment conducive to protein synthesis, facilitating muscle repair and growth after exercise. However, creatine faces challenges of instability in aqueous environments and at high temperatures, where it can degrade into creatinine, an inactive form that is not absorbed by the body, compromising its effectiveness in liquid or reconstitution formulations.

[0006] Another ingredient of growing interest for supplementation is turmeric, traditionally used as a dye, but which has been receiving attention due to its bioactive components, such as curcumin. Curcumin has potent antioxidant and anti-inflammatory properties, and is associated with several health benefits. However, the use of turmeric as a dietary supplement faces significant limitations, mainly related to its low bioavailability and solubility, which prevents its active constituents from being adequately absorbed by the body.

[0007] When combined, creatine and turmeric can offer a synergistic set of benefits for health and physical performance. Creatine, with its ability to improve muscle strength and accelerate recovery, complements the anti-inflammatory and antioxidant properties of curcumin, present in turmeric. Together, these substances can not only enhance muscle growth and recovery, but also reduce inflammation and oxidative stress, promoting a healthier environment for athletic performance and post-exercise recovery. In addition, turmeric may help mitigate some of the stability challenges of creatine, improving the overall effectiveness of supplementation.

[0008] Several compositions have attempted to combine bioactive ingredients to improve physical performance and muscle recovery, such as patent documents US 2011 / 064720, WO 2020 / 225608 and WO 2017 / 059101. However, these Petition 870240110444, dated 12 / 26 / 2024, page 12 / 36 3 / 20 formulations often treat creatine as a secondary or optional component, without exploring its full potential, and do not offer solutions for effectively combining creatine and turmeric in a stable and bioactive way, so as to provide all the benefits of the combination of active ingredients.

[0009] US patent 2011 / 064720 discloses three compositions that combine turmeric and resveratrol, in powder form for reconstitution into liquid or capsules, aimed at improving muscle recovery and physical performance. Furthermore, the document reveals the process for preparing said compositions for use as dietary supplements. Although creatine is mentioned, it is used in concentrations lower than the recommended daily dose for supplementation, being treated as an optional secondary component in the formulations, and does not assume a central role in the proposed efficacy for muscle recovery.

[0010] Document WO 2020 / 225608 refers to the use of a dietary supplement composed of turmeric combined with sulforaphane, intended to enhance physical performance during exercise. The document does not present any composition containing creatine as a component.

[0011] Document WO 2017 / 059101 discloses single-dose compositions and a food supplement intended to improve physical performance. The compositions in said document comprise proteins and carbohydrates in a weight ratio of approximately 0.5:1.

[0012] None of the prior art compositions provide dietary supplementation of creatine and turmeric in recommended daily supplementation amounts. Thus, it is evident that the technical problems of solubility, stability, and degradation of these bioactive compounds during the processing of a composition are technical obstacles that require innovative solutions.

[0013] It is against this backdrop that the invention in question arises, which provides a bioactive composition that combines creatine and turmeric in a matrix. Petition 870240110444, dated 12 / 26 / 2024, page 13 / 36 4 / 20 stable and effective, maximizing the bioavailability, absorption and efficacy of the two bioactive compounds, providing improvements in physical performance and muscle recovery. Objectives of the invention

[0014] The main objective of the invention is to provide a composition for food supplementation comprising creatine and turmeric as main bioactive ingredients in the recommended daily supplementation amounts. The composition of the present invention further comprises additional bioactive ingredients selected from the group comprising: amino acids, essential minerals and proteins of plant or animal origin. In addition, the composition of the present invention comprises at least one adjuvant selected from the group comprising acidifier, bulking agent, anti-caking agent, thickener, emulsifier, humectant, antioxidant, flavoring, sweetener, flavor enhancer, stabilizer and consistency or shape alterer.

[0015] Furthermore, one of the objectives of the invention is to provide a process for preparing the composition for food supplementation, in which said process occurs substantially without the addition of water.

[0016] It is also one of the objectives of the invention to manufacture a food supplement using the aforementioned bioactive composition and aimed at the recovery and maintenance of muscle health. Summary of the Invention

[0017] The objectives mentioned above are, in their entirety, achieved by the bioactive composition for food supplementation, by the process for its preparation, and by the use of the present invention.

[0018] According to the present invention, the bioactive composition comprises creatine and turmeric in the recommended daily supplementation amounts. Petition 870240110444, dated 12 / 26 / 2024, page 14 / 36 5 / 20

[0019] In one embodiment of the invention, the composition for food supplementation further comprises additional bioactive ingredients selected from the group comprising amino acids, essential minerals, proteins of plant or animal origin and combinations thereof.

[0020] In a preferred embodiment of the present invention, the composition for food supplementation further comprises adjuvants selected from the group comprising acidifier, bulking agent, anti-caking agent, thickener, emulsifier, humectant, antioxidant, flavoring, sweetener, flavor enhancer, stabilizer and consistency or shape alterer.

[0021] In a preferred embodiment of the invention, the composition for food supplementation is in a solid or semi-solid form.

[0022] Also according to the invention, the process for preparing the composition for food supplementation does not include a step of adding water.

[0023] The invention also relates to the use of the bioactive composition for the manufacture of a food supplement to aid in the recovery and maintenance of muscle health. Detailed Description of the Invention

[0024] In view of the objectives of the present invention, a composition for food supplementation comprising bioactive ingredients and adjuvants, a process for manufacturing said composition and its use as a food supplement is disclosed herein.

[0025] In one embodiment of the present invention, the dietary supplement composition comprises creatine and turmeric as the main bioactive ingredients, wherein creatine and turmeric are present in the composition in the recommended daily supplement amounts. Petition 870240110444, dated 12 / 26 / 2024, page 15 / 36 6 / 20

[0026] The term bioactive ingredient, as presented here, refers to a substance that has a metabolic or physiological action in the human body resulting in a positive effect on health.

[0027] The expression “recommended daily supplementation amount” refers to the recommended daily intake / supplementation of nutrients, bioactive ingredients, enzymes and / or probiotics so that these substances have the proposed beneficial effects. According to Normative Instruction No. 28 / 2018 of the National Health Surveillance Agency - Anvisa, the recommended daily dose for creatine supplementation is 3000 mg and 80 mg to 130 mg of curcumin to result in benefits to physical performance.

[0028] The ingredients of the composition may be used in free form or as salt or hydrate thereof, with the respective forms considered within the scope of the present invention.

[0029] As used herein, creatine refers to creatine, creatine monohydrate, anhydrous creatine, creatine HCl, micronized creatine, creatine nitrate, creatine phosphate, among others, and combinations thereof.

[0030] As used herein, turmeric refers to turmeric, extract of turmeric rhizomes, standardized turmeric extract, Long Vida turmeric, turmeric associated with a dispersion system, tetrahydrocurcuminoids obtained from turmeric extract, as well as their curcuminoids such as, for example, curcumin, desmethoxycurcumin, bis-desmethoxycurcumin, among others, and combinations thereof.

[0031] In a preferred embodiment of the invention, turmeric is associated with a dispersion system to increase its bioavailability. Non-exhaustive examples of curcumin with increased bioavailability include HydroCurc® and the active ingredient Long Vida. Petition 870240110444, dated 12 / 26 / 2024, p. 16 / 36 7 / 20

[0032] In another preferred embodiment of the invention, the creatine is creatine monohydrate and has a particle size between 80 and 400 mesh, equivalent to 180 μm and 37 μm, respectively, preferably 200 mesh or 75 μm.

[0033] In one embodiment of the invention, the said composition for food supplementation further comprises additional bioactive ingredients and adjuvants.

[0034] In a preferred embodiment of the invention, the additional bioactive ingredients are selected from the group comprising amino acids, essential minerals, plant or animal-derived proteins, and combinations thereof.

[0035] In another preferred embodiment of the invention, the adjuvants are selected from the group comprising acidifier, bulking agent, anti-caking agent, thickener, emulsifier, humectant, antioxidant, flavoring, sweetener, flavor enhancer, stabilizer, consistency or shape alterer and combinations thereof.

[0036] In one embodiment of the invention, the amino acid is selected from the group comprising arginine, beta-alanine, glutamine, isoleucine, leucine, valine, beta-hydroxy-beta-methylbutyrate (HMB) and its salt, namely: calcium hydroxymethylbutyrate (HMB Ca), tryptophan, taurine, threanine, citrulline, methionine, glycine, proline, alanine and combinations thereof, preferably arginine, L-arginine, L-arginine L-spartate and L-arginine hydrochloride.

[0037] In another embodiment of the invention, the essential mineral is selected from the group comprising magnesium, zinc, calcium, iron, chromium and salts, oxides or hydrates thereof; for example, magnesium chloride, magnesium bisglycinate, magnesium dimalate, magnesium citrate, magnesium acetyltaurate, magnesium malate, magnesium creatine, magnesium taurate, magnesium l-threonate, calcium hydroxide, calcium carbonate, calcium citrate, calcium malate, calcium oxide, calcium chloride, calcium phosphates, calcium sulfate, calcium lactate, Petition 870240110444, dated 12 / 26 / 2024, page 17 / 36 8 / 20 calcium benzoate, calcium ascorbate, calcium sorbate, calcium lactate gluconate, calcium propionate, calcium acetate, calcium caseinate, calcium cyclamate, calcium pantothenate, calcium stearate, calcium stearyl lactylate, calcium tartrate, zinc gluconate, iron bisglycinate, chromium picolinate and combinations thereof; preferably a magnesium salt, oxide or hydrate.

[0038] In one embodiment of the invention, the vegetable protein is a plant-based protein selected from the group comprising rice protein, pea protein, broad bean protein, chickpea protein, lentil protein and soy protein and combinations thereof.

[0039] In another embodiment of the invention, the animal protein is selected from the group comprising whey protein concentrate (WPC), milk protein concentrate, micellar casein, calcium caseinate, sodium caseinate, collagen, hydrolyzed collagen, collagen peptides, whey protein isolate (WPI) and combinations thereof.

[0040] In one embodiment of the invention, the acidifier is selected from the group comprising tartaric acid, citric acid, fumaric acid, malic acid, lactic acid, acetic acid, succinic acid, phosphoric acid, glutamic acid, adipic acid, sodium fumarates, hydrochloric acid, tripotassium citrate, potassium citrate, trisodium citrate, sodium bicarbonate, potassium bicarbonate, potassium carbonate, sodium carbonate, calcium hydroxide, potassium hydroxide and combinations thereof.

[0041] In one embodiment of the invention, the bulking agent is selected from the group comprising mannitol, microcrystalline cellulose, sorbitol, maltodextrin, dextrin, starch, lactose, inulin, pectin, polydextrose, xylitol, fructose, glycerol, maltitol syrup, sorbitol syrup, isomalt, maltitol and combinations thereof. Petition 870240110444, dated 12 / 26 / 2024, page 18 / 36 9 / 20

[0042] In one embodiment of the invention, the anti-caking agent is selected from the group comprising silicon dioxide, magnesium stearate, tricalcium phosphate, magnesium silicate (talc), calcium carbonate, modified starch, microcrystalline cellulose, isomalt, fatty acid salts, calcium silicate, calcium carbonate, magnesium carbonate, sodium carbonate, magnesium bicarbonate, sodium bicarbonate and magnesium oxide and combinations thereof.

[0043] In one embodiment of the invention, the thickener is selected from the group comprising guar gum, acacia gum, gum arabic, xanthan gum, gellan gum, polydextrose, carrageenan, carboxymethylcellulose, fructooligosaccharides (FOS), galactooligosaccharides (GOS), beta-glucan, inulin and combinations thereof.

[0044] In one embodiment of the invention, the emulsifier is selected from the group comprising lecithin such as soy lecithin and sunflower lecithin, mono- and diglycerides of fatty acids, polysorbate 80, sodium stearoyl lactylate, gum arabic and combinations thereof.

[0045] In one embodiment of the invention, the humectant is selected from the group comprising glycerin, polydextrose, sorbitol, propylene glycol, xylitol, maltitol, honey, natural extracts, triacetin, erythritol and combinations thereof.

[0046] In one embodiment of the invention, the antioxidant is selected from the group comprising tocopherols, ascorbic acid, potassium sorbate, ferulic acid, green tea extract, butylated hydroxyanisole, citric acid, natural extracts (e.g., rosemary), butylated hydroxytoluene (BHT), sodium ascorbate, potassium ascorbate, lecithin and ascorbyl palmitate and combinations thereof.

[0047] In one embodiment of the invention, the flavoring is selected from the group comprising mango flavor, peach flavor, orange flavor, tangerine flavor, yellow fruit flavor, mango powder, coffee flavor, cocoa powder and combinations thereof. Petition 870240110444, dated 12 / 26 / 2024, page 19 / 36 10 / 20

[0048] In one embodiment of the invention, the sweetener is selected from the group comprising sucralose, acesulfame K, steviol glycosides, thaumatin, erythritol, sorbitol, mannitol and combinations thereof.

[0049] In one embodiment of the invention, the flavoring is selected from the group comprising orange crispy, cocoa nibs, chocolate (sugar-free, white, milk, semi-sweet, among others), peanut brittle, dulce de leche, cocoa powder, vanillin, menthol, strawberry flavoring and combinations thereof.

[0050] In one embodiment of the invention, the stabilizer is selected from the group comprising maltitol syrup, sorbitol syrup, tapioca syrup, xanthan gum, guar gum, pectin, gelatin, modified starch, glucose syrup, fructose syrup, glycerin, glycerol, agave syrup and combinations thereof.

[0051] In one embodiment of the invention, the consistency or shape changer is selected from the group comprising sunflower oil, carboxymethylcellulose, coconut oil, cocoa butter, medium-chain triglycerides (MCTs) and combinations thereof.

[0052] In a preferred embodiment of the invention, the food supplement composition is in a solid or semi-solid form that can be reconstituted in liquid or is ready for consumption. Non-exhaustive examples of such forms include powder, granules, flakes, sachets, capsules, tablets, food bars, chewable tablets, orodispersible films, biscuits, cookies, gums, and snacks.

[0053] In a preferred embodiment of the invention, the solid or semi-solid presentation forms further comprise packaging of the final product with low hygroscopic materials that form a barrier against moisture. Furthermore, during the manufacturing process of the composition, the environment has controlled relative humidity, for example, with the use of a dehumidifier. Petition 870240110444, dated 12 / 26 / 2024, page 20 / 36 11 / 20

[0054] In a preferred embodiment of the invention, the composition for food supplementation is a composition in powder form for reconstitution in liquid.

[0055] In another preferred embodiment of the invention, the food supplement composition is a composition in the form of a food bar, even more preferably a ready-to-eat protein bar.

[0056] In one embodiment of the invention, the composition for food supplementation in the form of a liquid-reconstitutable powder comprises creatine, turmeric, at least one source of essential mineral, at least one source of amino acid, and adjuvants.

[0057] In a preferred embodiment of the invention, the composition for food supplementation in the form of a liquid-reconstitution powder comprises creatine, turmeric, at least one source of an essential mineral, at least one source of an amino acid, at least one sweetener, at least one bulking agent, at least one acidifier, at least one anti-caking agent, at least one thickener and at least one flavoring.

[0058] In a preferred embodiment of the invention, the composition for food supplementation in the form of a powder for reconstitution in liquid comprises: Creatine monohydrate in an amount of 35% to 55% by weight; Turmeric in an amount of 1% to 2.5% by weight; a source of essential minerals in an amount of 8.5% to 11% by weight; a source of amino acids in an amount of 10% to 15% by weight; sweetener in an amount of 0.1% to 0.3% by weight; bulking agent in an amount of 0.5% to 20% by weight; acidifier in an amount of 0% to 22% by weight; anti-caking agent in an amount of 0% to 5% by weight; Thickener in an amount of 0% to 5% by weight; Petition 870240110444, dated 12 / 26 / 2024, page 21 / 36 12 / 20 flavoring in an amount of 0% to 4% by weight; based on the total weight of the composition.

[0059] In one embodiment of the invention, the dietary supplement composition in the form of a liquid-reconstitutable powder provides a supplemental amount per dosage form of 3000 mg of creatine monohydrate, 80 mg of curcumin, 1000 mg of arginine and 130 mg of magnesium.

[0060] In one embodiment of the invention, the composition in powder form has a pH between 3.0 and 6.5 after reconstitution in water.

[0061] In a preferred embodiment of the invention, the creatine particle has a size ranging from 80 to 400 mesh (equivalent to 180 μm and 75 μm, respectively).

[0062] In a preferred embodiment of the invention, the mineral source particle has a size ranging from 10 to 300 micrometers.

[0063] In one embodiment of the invention, the composition for food supplementation in the form of a ready-to-eat food bar comprises creatine, turmeric, at least one vegetable protein source, collagen peptides, at least one other animal protein source and adjuvants.

[0064] In one embodiment of the invention, the composition for food supplementation in the form of a ready-to-eat food bar comprises creatine, turmeric, at least one vegetable protein source, collagen peptides, at least one other animal protein source, at least one sweetener, at least one stabilizer, at least one emulsifier, at least one humectant, at least one flavoring, at least one consistency or shape alterant, at least one antioxidant and at least one flavoring agent.

[0065] In a preferred embodiment of the invention, the composition for food supplementation in the form of a ready-to-eat food bar comprises: Petition 870240110444, dated 12 / 26 / 2024, page 22 / 36 13 / 20 creatine monohydrate in an amount of 5% to 10% by weight; Turmeric in an amount of 0.2% to 0.50% by weight; a source of plant-based protein in an amount of 5% to 20% by weight; collagen peptides in an amount of 20% to 30% by weight; another source of animal protein in an amount of 5% to 15% by weight; sweetener in an amount of 0% to 0.3% by weight; stabilizer in an amount of 15% to 35% by weight; emulsifier in an amount of 0.3% to 1% by weight; humectant in an amount of 3% to 10% by weight; flavoring in an amount of 1% to 7.5% by weight; consistency or shape alterant in an amount of 3% to 8% by weight; antioxidant in an amount of 0.05% to 1% by weight; and flavoring in an amount of 0% to 4% by weight; based on the total weight of the composition.

[0066] In one embodiment of the invention, the food supplement composition in the form of a food bar provides a supplemental amount per dosage form of 3000 mg of creatine monohydrate, 80 mg of curcumin, and 15.4 mg of protein.

[0067] In one embodiment of the invention, the process for preparing the composition for food supplementation comprises reducing the impact of water on the composition formed due to the instability of creatine in aqueous environments.

[0068] In one embodiment of the invention, the process for preparing the composition for food supplementation in powder form comprises the steps of: - Weigh and portion the ingredients; - Classify the initial fractions of creatine and amino acids and transfer them to a mixing machine; Petition 870240110444, dated 12 / 26 / 2024, page 23 / 36 14 / 20 - classify the source of essential minerals and also transfer it to the mixing equipment; - Perform an initial mixing for a specified period of time; - To prepare a premix of the adjuvants, sweetener with a portion of the acidifier and bulking agent, along with thickener and anti-caking agent, then classify the premixes and transfer them to the mixer; - Sort the remaining ingredients in the following order: second part of the acidifier, flavoring, and turmeric, and transfer to the mixer; - Sort the second fractions of creatine and amino acid source and transfer to the mixer; - perform a second mixing for a specified period of time; and - to package the final product.

[0069] In a preferred embodiment of the invention, the process for preparing the solid powder composition comprises dividing the quantities of creatine, amino acid and acidifier into two fractions.

[0070] In one embodiment of the invention, the process for preparing the composition for food supplementation in the form of a food bar comprises the following steps: I. Divide, mix all the powdered ingredients and set aside - except for the creatine; ii. Divide and mix the liquid adjuvants, the humectant, stabilizer and emulsifier, and heat gently; iii. add the consistency or shape changer in (ii) and mix; iv. add a portion of (i) to the syrup formed in (iii) and mix; v. homogenize and add the creatine and mix until the desired consistency is reached; vi. shape and cover with the flavoring coating; and Petition 870240110444, dated 12 / 26 / 2024, p. 24 / 36 15 / 20 vii. packaging the final product.

[0071] In one embodiment of the invention, the composition is used as a food supplement.

[0072] In a preferred embodiment of the invention, the composition is used as a food supplement acting in the recovery and maintenance of muscle health.

[0073] The present invention is described below with reference to the following examples, which are not intended to limit the scope of the present invention in any way.

[0074] In order to provide a more complete understanding of the modalities described here, the following examples are presented. It should be understood that these examples are for illustrative purposes only and should not be interpreted as being exhaustive. Example 1: Compositions comprising creatine and turmeric in a stable and bioactive form.

[0075] In a preferred embodiment, the powdered food supplement composition of the present invention comprises the ingredients in Table 1 below. Table 1 - Illustrative composition of the powder composition Description of Material Function % w / v Creatine Monohydrate Bioactive ingredient 35% to 55% Turmeric (Hydrocurc) Bioactive ingredient 1% to 2.5% Magnesium Bisglycinate Bioactive ingredient 8.5% to 11% Petition 870240110444, dated 12 / 26 / 2024, p. 25 / 36 16 / 20 L-arginine Bioactive ingredient 10% to 15% Sucralose Sweetener 0.1% to 0.3% Mannitol Bulking agent 0.5% to 20% Tartaric acid Acidifier 0% to 22% Anhydrous citric acid Acidifier 0% to 22% Silicon dioxide Anti-caking agent 0% to 5% Guar gum Thickener 0% to 5% Mango flavor Flavoring 0% to 4% Peach flavor Flavoring 0% to 4% Orange flavor Flavoring 0% to 4% Total 100 *This corresponds to a composition of 7.3 mg of product dissolved in 200 mL of water.

[0076] In another embodiment of the invention, the composition for food supplementation in the form of a food bar of the present invention comprises the ingredients in Table 2 below. Table 2 - Example composition of the solid composition in the form of a food bar. Material Description Function % w / v Petition 870240110444, dated 12 / 26 / 2024, page 26 / 36 17 / 20 Creatine Monohydrate Bioactive ingredient 5% to 10% Turmeric (Hydrocurc) Bioactive ingredient 0.2% to 0.50% Rice protein Bioactive ingredient 5% to 20% Pea protein Bioactive ingredient 5% to 20% Whey protein concentrate Bioactive ingredient 5% to 15% Collagen peptides Bioactive ingredient 20% to 30% Sucralose Sweetener 0% to 0.3% Maltitol syrup Stabilizer 15% to 35% Soy lecithin Emulsifier 0.3% to 1% Glycerin Humectant 3% to 10% Orange crisp Flavoring 1% to 7.5% Sunflower oil Consistency or shape alterant 3% to 8% Orange flavor Flavoring 0% 4% Coffee Flavoring, 0% to 4% Masking Flavoring, 0% to 4% Coating Flavoring QSP Petition 870240110444, dated 12 / 26 / 2024, page 27 / 36 18 / 20 DL-Alpha-Tocopherol Antioxidant 0.05% to 1% Total 100 Example 2: Process for preparing the composition comprising creatine and turmeric according to the invention.

[0077] In a preferred embodiment, the preparation of the powder composition of Example 1 was carried out in the following steps: (a) Weigh and divide the ingredients. For the ingredients creatine and arginine, the total amount weighed was divided into two equal fractions, each comprising approximately half the total mass of each ingredient. For the ingredient citric acid, the total amount was divided into two fractions in a 1:9 ratio (the first portion of citric acid contains approximately 10% and the second portion of citric acid contains approximately 90%); (b) classify the first fractions of creatine and arginine and transfer to the mixer; (c) classify the magnesium bisglycinate ingredient and then transfer it to the mixer, decreasing the direct contact surface of the creatine with the acids, preventing degradation of the bioactive ingredient; (d) mix the ingredients from steps (b) and (c); (e) perform the manual premixing of the ingredients, sucralose and the first portion of citric acid; (f) classify the mixture obtained in step (e) and transfer it to the mixer; (g) classify the tartaric acid ingredients and the second portion of citric acid and then transfer to the mixer; (h) mix the ingredients from steps (f) and (g) together with the first mixture; Petition 870240110444, dated 12 / 26 / 2024, page 28 / 36 19 / 20 (i) perform manual premixing of the ingredients, mannitol, silicon dioxide and guar gum; (j) classify the mixture obtained in step (h) and transfer it to the mixer; (k) classify the ingredients in the following order: flavorings and turmeric and transfer to the mixer; (l) classify the second fractions of creatine and arginine and transfer to the mixer; (m) to mix all the ingredients; (n) proceed with packaging the final product.

[0078] The premixes and the order in which the raw materials passed through the sieving screens were carried out considering the concentrations, physicochemical characteristics, compatibility and functions of the ingredients, in order to guarantee their quality, good processability and uniformity of the final product.

[0079] In a preferred embodiment, the preparation of the composition in the form of a food bar in Example 1 was carried out in the following steps: (a) Fractionate the solid ingredients creatine, turmeric, rice proteins, pea proteins, animal protein (WPC), collagen peptides, sucralose, orange crisp and flavorings and set aside; (b) mix the ingredients turmeric, sucralose, antioxidant and masking (flavoring); (c) add the ingredients rice proteins, pea proteins, animal protein (WPC), collagen peptides and flavorings to the mixture obtained in item (b) and set aside; (d) mix the liquid ingredients glycerin, maltitol syrup and soy lecithin in a system heated to a temperature between 80 and 110 °C; (e) stop heating the system and add the sunflower oil to the mixture obtained in step (d); Petition 870240110444, dated 12 / 26 / 2024, pp. 29 / 36 20 / 20 (f) perform the broth mixing; (g) add the powder obtained in step (c) to the broth formed in (e) and proceed with mixing until a semi-solid mass is formed; (h) add and mix the creatine under the dough from step (g) and mix until homogeneous; (i) shape the dough obtained in (h) by pressing and rolling it, and then add the orange crisp; (j) cool the system and perform the bar cutting; (k) cover the bars obtained in (j) with a covering; and (l) package the final product.

[0080] Having described the embodiments of the composition, use and manufacturing process, it should be understood that the scope of protection in question also covers variations not described, but derived or equivalent. Petition 870240110444, dated 12 / 26 / 2024, pages 30 / 36

Claims

1 / 5 CLAIMS 1. Composition for food supplementation CHARACTERIZED by the fact that it comprises turmeric and creatine in recommended daily supplementation amounts, wherein the amount of turmeric is about 0.2% to 2.5% by weight and the creatine is about 5% to 55% by total weight of the composition.

2. Composition, according to claim 1, CHARACTERIZED in that it further comprises additional bioactive ingredients selected from the group consisting of amino acids, essential minerals, proteins of animal origin, proteins of vegetable origin or a combination thereof.

3. Composition, according to claim 1 or 2, CHARACTERIZED in that it comprises adjuvants selected from the group consisting of acidifier, bulking agent, anti-caking agent, thickener, emulsifier, humectant, antioxidant, flavoring, sweetener, flavor enhancer, stabilizer, consistency or shape alterer, or a combination thereof.

4. Composition, according to any one of claims 1 to 3, CHARACTERIZED in that it is in a solid or semi-solid form, reconstitutable in liquid or ready for consumption.

5. Composition for liquid reconstitution food supplementation CHARACTERIZED by the fact that it comprises turmeric, creatine, at least one amino acid, at least one essential mineral and adjuvants.

6. Liquid reconstitution composition according to claim 5, CHARACTERIZED in that the particle size of the creatine is between 80 and 400 mesh or 180 μm and 37 μm.

7. Liquid reconstitution composition, according to claim 5 or 6, CHARACTERIZED in that the essential mineral is a magnesium source selected from the group comprising magnesium bisglycinate, magnesium dimalate, magnesium citrate, magnesium acetyltaurate, magnesium malate, magnesium creatine, magnesium taurate, magnesium chloride, magnesium threonate and combinations thereof.

8. Liquid reconstitution composition according to any one of claims 5 to 7, CHARACTERIZED in that the amino acid is L-arginine or a salt thereof.

9. Liquid reconstitution composition, according to any one of claims 5 to 8, CHARACTERIZED in that the adjuvant is at least one selected from: a sweetener selected from sucralose, acesulfame K, steviol glycosides, thaumatin, erythritol, sorbitol, mannitol and combinations thereof; a bulking agent selected from mannitol, microcrystalline cellulose, sorbitol, maltodextrin, dextrin, starch, lactose, inulin, pectin, polydextrose, xylitol, fructose, glycerol, maltitol syrup, sorbitol syrup, isomalt, maltitol and combinations thereof;An acidifying agent selected from tartaric acid, citric acid, fumaric acid, malic acid, lactic acid, acetic acid, succinic acid, phosphoric acid, glutamic acid, adipic acid, sodium fumarate, hydrochloric acid, tripotassium citrate, potassium citrate, trisodium citrate, sodium bicarbonate, potassium bicarbonate, potassium carbonate, sodium carbonate, calcium hydroxide, potassium hydroxide and combinations thereof. An anti-caking agent selected from silicon dioxide, magnesium stearate, tricalcium phosphate, magnesium silicate (talc), calcium carbonate, modified starch, microcrystalline cellulose, isomalt, fatty acid salts, calcium silicate, calcium carbonate, magnesium carbonate, sodium carbonate, magnesium bicarbonate, sodium bicarbonate and magnesium oxide and combinations thereof;a thickener selected from guar gum, acacia gum, gum arabic, xanthan gum, gellan gum, polydextrose, carrageenan, carboxymethylcellulose, Petition 870240110444, dated 12 / 26 / 2024, page 32 / 36 3 / 5 fructooligosaccharides, galactooligosaccharides, beta-glucan, inulin and combinations thereof; and / or a flavoring selected from the group comprising mango flavor, peach flavor, orange flavor, tangerine flavor, yellow fruit flavor, mango powder, coffee flavor, cocoa powder and combinations thereof.

10. Liquid reconstitution composition, according to any one of claims 5 to 9, CHARACTERIZED in that the pH of the composition after reconstitution in water is between 3.0 and 6.

5.

11. Composition for food supplementation CHARACTERIZED by the fact that it comprises turmeric, creatine, proteins of vegetable and animal origin, and adjuvants.

12. Composition, according to claim 11, CHARACTERIZED in that: the vegetable proteins are selected from the group comprising rice protein, pea protein, broad bean protein, chickpea protein, lentil protein, soy protein and combinations thereof; and the animal proteins are selected from the group comprising whey protein concentrate, milk protein concentrate, micellar casein, calcium daisylate and sodium caseinate, collagen, hydrolyzed collagen, collagen peptides, Whey Protein Isolate (WPI) and combinations thereof.

13. Composition, according to claim 11 or 12, CHARACTERIZED in that the adjuvant is at least one selected from: a sweetener selected from sucralose, acesulfame K, steviol glycosides, thaumatin, erythritol, sorbitol, mannitol and combinations thereof; a stabilizer selected from maltitol syrup, sorbitol syrup, tapioca syrup, xanthan gum, guar gum, pectin, gelatin, modified starch, glucose syrup, fructose syrup, glycerin, glycerol, agave syrup and combinations thereof; an emulsifier selected from soy lecithin, sunflower lecithin, mono- and diglycerides of fatty acids, polysorbate 80, sodium stearoyl lactylate, gum arabic and combinations thereof; a humectant selected from glycerin, polydextrose, sorbitol, propylene glycol, xylitol, maltitol, honey, natural extracts, triacetin, erythritol and combinations thereof;A flavoring selected from among orange crisps, cocoa nibs, sugar-free chocolate, white chocolate, milk chocolate, semi-sweet chocolate, peanut brittle, dulce de leche, cocoa powder, vanillin, menthol, strawberry flavoring, and combinations thereof; a consistency or shape alterant selected from among sunflower oil, carboxymethylcellulose, coconut oil, glycerin, cocoa butter, medium-chain triglycerides (MCTs), and combinations thereof; an antioxidant selected from among tocopherols, ascorbic acid, potassium sorbate, ferulic acid, green tea extract, butylated hydroxyanisole, citric acid, natural extracts, butylated hydroxytoluene, sodium ascorbate, potassium ascorbate, lecithin, and ascorbyl palmitate, and combinations thereof; and a flavoring selected from the group comprising mango flavoring, peach flavoring, orange flavoring, tangerine flavoring, yellow fruit flavoring, mango powder, coffee flavoring, cocoa powder, and combinations thereof.

14. Composition for food supplementation, according to any one of claims 1 to 13, CHARACTERIZED in that turmeric is associated with a dispersion system to increase its bioavailability.

15. Process for preparing compositions for food supplementation, as defined in any of claims 1 to 14, CHARACTERIZED by the fact that it occurs without the addition of water. Petition 870240110444, dated 12 / 26 / 2024, pp. 34 / 36 5 / 5 16. Use of the compositions, as defined in any of claims 1 to 14, CHARACTERIZED by the fact that it is for the manufacture of a food supplement for the recovery and maintenance of muscle health. Petition 870240110444, dated 12 / 26 / 2024, pp. 35 / 36