Delayed disintegration-type capsule and method for producing same
By integrating an amphoteric surfactant and specific melting point fats into the capsule core, the disintegration of seamless capsules is delayed and pH-independent, addressing design limitations and ensuring targeted delivery.
CA3139731CActive Publication Date: 2026-07-07MORISHITA JINTAN CO LTD
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Patent Information
- Application Number
- CA3139731
- Authority / Receiving Office
- CA · CA
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2019-06-14
- Filing Date
- 2020-06-12
- Publication Date
- 2026-07-07
- Estimated Expiration
- 2040-06-12
AI Technical Summary
Technical Problem
Existing seamless capsules lack the ability to effectively delay disintegration and offer limited design freedom due to the reliance on film layers that are sensitive to pH changes in the gastrointestinal tract.
Method used
Incorporating an amphoteric surfactant, such as lecithin, into the core of the capsule, combined with fats having specific melting points and a water-soluble natural polymer outermost layer, allows for controlled disintegration independent of pH changes.
Benefits of technology
This approach enables delayed disintegration and enhanced design flexibility, allowing the capsule to maintain integrity through the stomach and small intestine before disintegrating in the large intestine, thus ensuring targeted delivery of active substances.
✦ Generated by Eureka AI based on patent content.
Abstract
An object of the present invention is to provide a technique for delaying disintegration of a capsule by blending a certain component in a core of the capsule, and to increase the degree of freedom in capsule design. The present invention relates to a delayed disintegration-type seamless capsule that is a seamless capsule including a core, one or more intermediate layers formed on the core, and an outermost layer formed on the intermediate layers, wherein the core contains an active substance, an amphoteric surfactant, and a fat having a melting point of 40C or more, at least one layer of the intermediate layers contains a fat having a melting point of 45C or more, and the outermost layer contains a water-soluble natural polymer. The present invention also relates to a method for producing the same.
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