Composition for relieving bloating and treating stomachache and preparation method thereof

Abstract

The present invention discloses a swell-relief and stomachache reliever and a preparation method thereof, relating to the technical field of veterinary medicines; the swell-relief and stomachache reliever comprises the following components in parts by weight: 10-15 parts of Sichuan costus root, 10-15 parts of dried tangerine peel, 7-12 parts of Chuanxiong rhizome, 3.5-7 parts of angelica dahurica, 7-10 parts of fennel seeds, and 3.5-7 parts of clematis root. The present invention also provides a preparation method for the swell-relief and stomachache reliever. The swell-relief and stomachache reliever of the present invention is an effective Chinese patent medicine for treating spleen deficiency, flatulence, and abdominal pain caused by spleen and stomach diseases, so as to prevent and treat spleen and stomach diseases in cattle and sheep, and to protect cattle and sheep breeding.

Description

Technical Field

[0001] The present invention relates to the technical field of veterinary medicines, and in particular to a composition for relieving bloating and treating stomachache and a preparation method thereof. Background Art

[0002] my country is a major producer and consumer of both beef and mutton. Mutton production consistently ranks first in the world, and beef production ranks third, after Brazil and the United States. In recent years, my country's beef and mutton production has continued to grow steadily. In 2015, beef production reached 7 million tons and mutton production reached 4.41 million tons, representing year-on-year increases of 1.6% and 2.9%, respectively. Per capita beef consumption is 5.1 kilograms, about half the global average, and per capita mutton consumption is 3.2 kilograms, about 1.6 times the global average. From the beginning of the new century to 2014, due to various factors, beef and mutton prices rose rapidly, leading to tight supply in some ethnic minority areas and sparking widespread public concern. The main reason for the continued rapid rise in beef and mutton prices is that consumption has outpaced production growth. Beef and mutton consumption has shifted from regional to national, from ethnic minority consumption to universal consumption, and from seasonal consumption to year-round consumption. Overall, consumer demand has accelerated, with total supply exceeding demand.

[0003] Cattle and sheep are both herbivorous mammals. Food is mainly digested through the spleen and stomach. The spleen and stomach are important digestive systems for cattle and sheep. If the spleen and stomach function abnormally, the digestive ability of cattle and sheep will be greatly reduced.

[0004] If there are symptoms of spleen and stomach, it will affect the normal eating of cattle and sheep. In mild cases, it will be detrimental to the growth and development of cattle and sheep, and in severe cases, it will lead to the death of cattle and sheep. There are many types of spleen and stomach diseases in cattle and sheep, and there are many treatments. The illness of cattle and sheep will cause considerable economic losses to farmers, and it will not promote the sustainable development of the farm. The more common disease in cattle and sheep farming is spleen and stomach disease. Spleen and stomach disease in cattle and sheep will damage the breeding efficiency and hinder the development of the farm. With the expansion of the scale of many farms, although it has brought considerable profits, the incidence of spleen and stomach disease in cattle and sheep has also increased significantly. Therefore, actively analyzing the causes and taking effective treatment measures are the key.

[0005] In the development of the cattle and sheep farming industry, spleen and stomach diseases are common, with high incidence and significant negative impacts. This requires strengthening the prevention and treatment of spleen and stomach diseases in cattle and sheep, researching their causes, and developing targeted treatment strategies to ensure the overall benefits of cattle and sheep farming. From a Traditional Chinese Medicine perspective, the spleen and stomach are fundamental to the generation of Qi and blood in cattle and sheep. Diseased spleen and stomach conditions can affect appetite, reduce rumination, and lead to lethargy, which is detrimental to their healthy growth and development. Without proactive treatment, mortality rates can also increase. Cattle and sheep have interconnected internal organs, and damage to the spleen and stomach can also lead to other diseases. Therefore, proactive treatment of spleen and stomach diseases and their rapid recovery is the best way to ensure economic returns for farmers.

[0006] But, mainly now clinically, grass-roots veterinarians differentiate and prescribe, there is no standardized Chinese patent medicine, current grass-roots veterinarians are fewer and fewer, and the veterinarian who understands Chinese veterinary theory and technology is even less, can not meet the needs of preventing and treating spleen and stomach diseases in cattle and sheep. For this reason, around the gastrointestinal diseases such as spasmodic hernia, wind hernia, flatulence, rheumatic pain in ruminants, under the guidance of Chinese veterinary theory, the design of prescription is carried out. Determine this prescription on the basis of clinical differentiation of symptoms and treatment, on the basis of effectively, carry out new Chinese veterinary medicine research, with it provide basis and new Chinese veterinary medicine for clinical prevention and treatment of spleen and stomach diseases in cattle and sheep. At present, there is no effective Chinese patent medicine for treating spleen deficiency and abdominal pain caused by spleen and stomach diseases in China. Summary of the Invention

[0007] In order to solve the above technical problems, the purpose of the present invention is to provide a Xiaozhang Weitongshu and a preparation method thereof. The Xiaozhang Weitongshu is an effective Chinese patent medicine for treating spleen deficiency, bloating and abdominal pain caused by spleen and stomach diseases, so as to prevent and treat spleen and stomach diseases in cattle and sheep, and to protect cattle and sheep breeding.

[0008] The technical solution of the present invention for solving the above technical problems is as follows: providing a bloating and stomach pain reliever, comprising the following components in parts by weight: 10-15 parts of Sichuan costus root, 10-15 parts of dried tangerine peel, 7-12 parts of Chuanxiong, 3.5-7 parts of angelica dahurica, 7-10 parts of fennel and 3.5-7 parts of clematis.

[0009] Furthermore, the bloating and stomach pain relief product comprises the following components in parts by weight: 13 parts of Sichuan costus root, 13 parts of dried tangerine peel, 9 parts of Chuanxiong rhizome, 5 parts of angelica dahurica, 8 parts of fennel and 6 parts of clematis root.

[0010] The present invention also provides a preparation method of the above-mentioned Xiaozhang Weitongshu, comprising the following steps:

[0011] (1) Add water to decoct Radix Aucklandiae Root, dried tangerine peel, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Fennel and Radix Clematis Root for 3 times, combine the extracts, filter, concentrate, then add a precipitant, stir, let stand, filter, and collect the filtrate; collect the distillate for later use;

[0012] (2) Separate the volatile oil from the distillate obtained in step (1), then mix the volatile oil with an equal amount of Tween-80, add it to the distillate and mix it, adjust the pH to 4-7, filter, package, seal and sterilize in sequence to obtain Xiaozhang Weitongshu injection.

[0013] Oral liquid can also be prepared, specifically as follows: in step (2), the volatile oil in the distillate obtained in step (1) is separated, and then an equal amount of Tween-80 and the volatile oil are mixed and evenly mixed, and then added to the water extract concentrate, and 0.1-0.6% preservative is added, and the pH is adjusted to 5.5-7, filtered, and sterilized to obtain the Xiaozhangweitongshu oral liquid.

[0014] Furthermore, the preservative is sodium benzoate.

[0015] Furthermore, in step (2), sterilize at 100°C for 20-40 minutes.

[0016] Furthermore, in step (1), the mixture is concentrated to 0.5-0.8 of the original volume.

[0017] The present invention has the following beneficial effects:

[0018] 1. The Xiaozhang Weitongshu of the present invention is an effective Chinese patent medicine for treating spleen deficiency, flatulence and abdominal pain caused by spleen and stomach diseases, which can prevent and treat spleen and stomach diseases in cattle and sheep, and protect cattle and sheep breeding. At the same time, under the guidance of Chinese veterinary theory, the dialectical design of prescriptions is carried out; new Chinese veterinary medicines are studied to provide effective Chinese patent veterinary medicines for clinical use, which can prevent and treat spleen and stomach diseases in cattle and sheep, and protect cattle and sheep breeding. It is beneficial to promote cattle and sheep breeding and improve economic benefits. It is expected that the sales volume of a single product will reach more than 20 million in three years. In addition, Chinese veterinary medicines can promote the reduction and replacement of antibiotics, which is beneficial to the production of green food and meet people's demand for healthy food. At the same time, the research and development of new Chinese veterinary medicines can improve competitiveness and be beneficial to innovation and development.

[0019] 2. Costus root in Xiaozhang Weitongshu is known to promote qi and relieve pain. Costus root is used to treat abdominal distension and pain, indigestion, flank discomfort, liver and gallbladder pain, and diarrhea, with remarkable efficacy; it is the primary herb. Tangerine peel strengthens the spleen and appetite, expels dampness and resolves phlegm. Its unique aroma improves appetite, promotes digestive juice secretion, enhances intestinal function, and relieves symptoms such as abdominal distension, loss of appetite, anorexia, vomiting, and diarrhea; it is the primary herb. Chuanxiong rhizome promotes blood circulation, dispels stasis, dispels wind, and relieves pain; it is an adjuvant. Fennel warms the middle and regulates qi, harmonizing the stomach. The aromatic oil in fennel accelerates digestive juice secretion, speeds up gastrointestinal motility, and eliminates food stagnation, thereby relieving symptoms such as nausea and vomiting caused by stomach cold and abdominal pain; it is an adjuvant. Notopterygium root can relieve exterior symptoms, dispel cold, expel wind and dampness, and relieve pain; it is an adjuvant. Smilax glabra generally has the effects of dispelling wind and dampness, unblocking meridians and relieving pain, and antibacterial. It has a good effect on clearing gastrointestinal stagnation; adjuvant. DETAILED DESCRIPTION

[0020] The principles and features of the present invention are described below. The examples are intended only to illustrate the present invention and are not intended to limit the scope of the present invention. In the examples, where specific conditions are not specified, conventional conditions or manufacturer-recommended conditions were used. Reagents or instruments used where the manufacturer is not specified are conventional products that can be purchased commercially.

[0021] Example 1

[0022] A medicine for relieving bloating and stomach pain comprises the following components in parts by weight: 10 kg of Radix Aucklandiae Root, 10 kg of dried tangerine peel, 7 kg of Rhizoma Chuanxiong, 3.5 kg of Angelica dahurica, 7 kg of Fennel and 3.5 kg of Radix Clematis.

[0023] The preparation method of the above-mentioned Xiaozhang Weitongshu comprises the following steps:

[0024] (1) Add water to decoct Radix Aucklandiae Root, dried tangerine peel, Rhizoma Chuanxiong, Rhizoma Angelicae Pubescentis, Fennel and Clematidis Radix for 3 times, combine the extracts, filter, and concentrate to 0.5 of the original volume, then add a precipitant, stir, let stand, filter, and collect the filtrate; collect the distillate for later use;

[0025] (2) Separate the volatile oil from the distillate obtained in step (1), then mix the volatile oil with an equal amount of Tween-80, add the mixture to the distillate and mix well, adjust the pH to 4-7, filter, package, seal, and sterilize at 100°C for 30 minutes to obtain Xiaozhang Weitongshu injection.

[0026] Example 2

[0027] A medicine for relieving bloating and stomach pain comprises the following components in parts by weight: 13 kg of Radix Aucklandiae Root, 13 kg of dried tangerine peel, 9 kg of Rhizoma Chuanxiong, 5 kg of Angelica dahurica, 8 kg of Fennel and 6 kg of Radix Clematis.

[0028] The preparation method of the above-mentioned Xiaozhang Weitongshu comprises the following steps:

[0029] (1) Add water to decoct Radix Aucklandiae Root, dried tangerine peel, Rhizoma Chuanxiong, Rhizoma Angelicae Pubescentis, Fennel and Clematidis Radix for 3 times, combine the extracts, filter, and concentrate to 0.6 of the original volume, then add a precipitant, stir, let stand, filter, and collect the filtrate; collect the distillate for later use;

[0030] (2) Separate the volatile oil from the distillate obtained in step (1), then mix the volatile oil with an equal amount of Tween-80, add the mixture to the distillate and mix well, adjust the pH to 4-7, filter, package, seal, and sterilize at 100°C for 30 minutes to obtain Xiaozhang Weitongshu injection.

[0031] Example 3

[0032] A medicine for relieving bloating and stomach pain comprises the following components in parts by weight: 14 kg of Radix Aucklandiae Root, 14 kg of dried tangerine peel, 11 kg of Rhizoma Chuanxiong, 6 kg of Angelicae Pubescentis, 9 kg of Fennel and 6 kg of Radix Clematis.

[0033] The preparation method of the above-mentioned Xiaozhang Weitongshu comprises the following steps:

[0034] (1) Add water to decoct Radix Aucklandiae Root, dried tangerine peel, Rhizoma Chuanxiong, Rhizoma Angelicae Pubescentis, Fennel and Clematidis Radix for 3 times, combine the extracts, filter, and concentrate to 0.7 of the original volume, then add a precipitant, stir, let stand, filter, and collect the filtrate; collect the distillate for later use;

[0035] (2) Separate the volatile oil from the distillate obtained in step (1), then mix it with an equal amount of Tween-80 and the volatile oil, add it to the water extract concentrate, and add 0.1-0.6% of a preservative (sodium benzoate), adjust the pH to 5.5-7, filter, and obtain Xiaozhang Weitongshu oral liquid.

[0036] Example 4

[0037] A medicine for relieving bloating and stomach pain comprises the following components in parts by weight: 15 kg of Radix Aucklandiae Root, 15 kg of dried tangerine peel, 12 kg of Rhizoma Chuanxiong, 7 kg of Angelicae Pubescentis, 10 kg of Fennel Seed and 7 kg of Radix Clematis.

[0038] The preparation method of the above-mentioned Xiaozhang Weitongshu comprises the following steps:

[0039] (1) Add water to decoct Radix Aucklandiae Root, dried tangerine peel, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Fennel and Radix Clematis Root for 3 times, combine the extracts, filter, and concentrate to 0.8 of the original volume, then add a precipitant, stir, let stand, filter, and collect the filtrate; collect the distillate for later use;

[0040] (2) Separate the volatile oil from the distillate obtained in step (1), then mix it with an equal amount of Tween-80 and the volatile oil, add it to the water extract concentrate, and add 0.1-0.6% of a preservative (sodium benzoate), adjust the pH to 5.5-7, filter, and obtain Xiaozhang Weitongshu oral liquid.

[0041] Test example

[0042] The experimental animals were Simmental beef cattle, which were provided by a livestock company in Zalantun City, Inner Mongolia. According to the principle of "same breed and similar weight", 27 cattle with an average weight of 200kg±5kg were randomly selected from the fattening group. They were randomly divided into 9 groups, with 3 cattle in each group, namely A1, B1, C1, D1, A2, B2, C2, D2, and E groups. After the cattle were divided into pens and fed normally for 7 days, they were replaced with conventional feed from another manufacturer and moist green and juicy alfalfa. After 2 days of use, all of them developed rumen bloating, did not ruminate, and did not eat. Percussion of the swollen area revealed tympanic sounds, and auscultation revealed forestomach sluggishness.

[0043] Group A1 received an intramuscular injection of 20 mL of the sterilized Xiaozhang Weitongshu injection from Example 1; Group B1 received an intramuscular injection of 20 mL of the sterilized Xiaozhang Weitongshu injection from Example 2; Group C1 received an intramuscular injection of 20 mL of neostigmine methylsulfate injection produced by a certain company and meeting national standards (a control group for a similar product); Group D1 received an intramuscular injection of 20 mL of a sterile solution without traditional Chinese medicine (a negative control group); and Group E received no treatment (a blank control group). For patients with severe flatulence and forestomachal atony, another injection was administered eight hours later. If the effect was unsatisfactory, the injection was continued the next day.

[0044] Group A1: After a single intramuscular injection, the patient recovered normal rumination and appetite 1-2 hours later.

[0045] Group B1: One intramuscular injection of the drug was performed. Two of the animals recovered to normal rumination and appetite after 1-2 hours. The other animal recovered after two intramuscular injections.

[0046] Group C1: Two cows recovered to normal after 4 intramuscular injections, and one cow died of food accumulation and flatulence.

[0047] Group D1: All three cows died of bloating.

[0048] Group E: All three cows died of bloating.

[0049] Conclusion: Both A1 and B1 Chinese herbal injections are effective in treating rumen flatulence and non-rumination in cattle, but the effect of the formula used in group A1 is the most prominent. Compared with the similar product group C1, the effects of groups A1 and B1 are better than those of group C1.

[0050] Group A2 was then gavage-administered 500 mL of Xiaozhang Weidongshu oral solution from Example 3; Group B2 was gavage-administered 500 mL of Xiaozhang Weidongshu oral solution from Example 4; Group C2 was gavage-administered 500 mL of a vitamin B complex solution produced by a certain company and meeting national standards (a control group for a similar product); Group D2 was gavage-administered 500 mL of a test solution without added traditional Chinese medicine ingredients (a negative control group); and Group E received no treatment (a blank control group). For patients with severe flatulence and forestomachal atony, the drug was administered again 8 hours later. If the effect was unsatisfactory, gavage administration was continued the next day.

[0051] Group A2: After a single gavage, the patient recovered normal rumination and appetite 1-2 hours later.

[0052] Group B2: After one gavage administration, two of the animals recovered to normal rumination and appetite 1-2 hours later, and the other one recovered after two gavage administrations.

[0053] Group C2: One cow recovered to normal after 3 oral administrations, one cow recovered to normal after 5 oral administrations, and one cow died of food accumulation and flatulence.

[0054] Group D2: All three cows died of bloating.

[0055] Group E: All three cows died of bloating.

[0056] Conclusion: Both A2 and B2 oral Chinese medicine solutions are effective in treating rumen bloating and reflux in cattle, but the effect of A2 is the most prominent. Compared with the similar product C2, both A2 and B2 are better than C2.

[0057] Therefore, the Xiaozhang Weitongshu of the present invention is an effective Chinese patent medicine for treating spleen deficiency, flatulence and abdominal pain caused by spleen and stomach diseases, and can prevent and treat spleen and stomach diseases in cattle and sheep.

[0058] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A composition for relieving bloating and treating stomachache, characterized in that: The invention is prepared from the following components in parts by weight: 10-15 parts of Sichuan costus root, 10-15 parts of dried tangerine peel, 7-12 parts of chuanxiong rhizome, 3.5-7 parts of angelica dahurica, 7-10 parts of fennel and 3.5-7 parts of clematis root.

2. The composition for relieving bloating and treating stomachache according to claim 1, characterized in that: The invention is prepared from the following components in parts by weight: 13 parts of Sichuan costus root, 13 parts of dried tangerine peel, 9 parts of chuanxiong rhizome, 5 parts of angelica dahurica, 8 parts of fennel and 6 parts of clematis root.

3. The method for preparing the composition for relieving bloating and treating stomachache according to any one of claims 1 to 2, characterized in that: The following steps are involved: (1) Add water to decoct Radix Aucklandiae Root, dried tangerine peel, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Fennel and Radix Clematis Root for 3 times, combine the extracts, filter, concentrate, then add a precipitant, stir, let stand, filter, and collect the filtrate; collect the distillate for later use; (2) Separate the volatile oil from the distillate obtained in step (1), then mix an equal amount of Tween-80 with the volatile oil, add it to the distillate and mix it, adjust the pH to 4-7, filter, package, seal and sterilize in sequence to obtain an injection of a composition for relieving bloating and treating stomach pain.

4. The method for preparing the composition for relieving bloating and treating stomachache according to claim 3, wherein: In step (2), the volatile oil in the distillate obtained in step (1) is separated, and then an equal amount of Tween-80 and the volatile oil is mixed and evenly added to the aqueous extract concentrate, and 0.1-0.6% of a preservative is added, and the pH is adjusted to 5.5-7, filtered, and sterilized to obtain an oral liquid composition for relieving bloating and treating stomach pain.

5. The method for preparing the composition for relieving bloating and treating stomachache according to claim 4, wherein: The preservative is sodium benzoate.

6. The method for preparing the composition for relieving bloating and treating stomachache according to claim 3, wherein: In step (2), sterilize at 100°C for 20-40 minutes.

7. The method for preparing the composition for relieving bloating and treating stomachache according to claim 3, wherein: In step (1), concentrate to 0.5-0.8 of the original volume.