A traditional chinese medicine composition for improving hypertension

Abstract

This invention discloses a traditional Chinese medicine composition for improving hypertension, belonging to the field of traditional Chinese medicine compound preparation technology. This invention targets the core pathogenesis of hypertension caused by phlegm-dampness obstruction and peripheral microcirculation disorders, leading to abnormal activation of the hypothalamic-sympathetic-cardiac axis and compensatory cardiac hypertensive. The treatment principle is to resolve phlegm and dampness, and invigorate blood circulation. It is formulated with nutmeg, allium macrostemon, amomum villosum, peach kernel, safflower, platycodon grandiflorus, angelica dahurica, and tangerine peel. This combination can dredge the meridians, improve peripheral blood supply, and alleviate cardiac compensatory pumping, thus addressing hypertension caused by phlegm-dampness obstruction at its root. The formula is scientifically formulated, highly safe, and easy to prepare, making it suitable for long-term treatment and industrial promotion.

Description

Technical Field

[0002] This invention relates to the field of traditional Chinese medicine composition technology, specifically to a traditional Chinese medicine composition with the core functions of resolving phlegm and dampness, promoting blood circulation and unblocking the meridians, and targeting hypertension caused by phlegm and dampness obstruction, poor blood circulation, peripheral microcirculation disorders, and compensatory hypertensive ... Background Technology

[0004] Hypertension is a prevalent chronic cardiovascular disease worldwide, characterized by persistently elevated arterial blood pressure. Poor long-term blood pressure control can induce various cardiovascular and cerebrovascular complications such as stroke, coronary heart disease, kidney damage, myocardial hypertrophy, and impaired cardiac function, seriously endangering human health and public health safety. Modern cardiovascular pathology research has confirmed that the hypothalamus, as the blood pressure regulatory center, receives signals of ischemic peripheral microcirculation and regulates cardiac pumping and vascular tone through the sympathetic nervous system. Peripheral microcirculatory disturbances, abnormal blood rheology, hypothalamic-sympathetic-cardiac axis dysregulation, and long-term compensatory high-load cardiac pumping are the core pathological mechanisms of the occurrence and progression of essential hypertension.

[0005] Modern cardiovascular pathology research confirms that when peripheral microcirculatory vessels are narrowed and peripheral tissues experience persistent ischemia and hypoxia, the hypothalamic blood pressure regulation center continuously receives ischemic feedback signals. This triggers an increase in cardiac pumping frequency and pressure via the sympathetic-humoral pathway, placing the heart in a state of compensatory high workload for an extended period. Increased peripheral vascular resistance and impaired blood flow directly increase the heart's ejection load. The heart compensates by increasing myocardial contractility and heart rate, and this long-term compensatory pumping ultimately leads to persistent hypertension, while also causing myocardial hypertrophy and impaired cardiac function. Traditional yin-nourishing and fire-reducing treatments, as well as Western diuretics, cannot improve peripheral microcirculatory ischemia or eliminate the underlying causes of cardiac compensation. They only provide short-term blood pressure reduction, leaving the high-load compensatory heart functioning continuously, and blood pressure is highly susceptible to rebound and fluctuation.

[0006] Traditional Chinese medicine (TCM) categorizes hypertension under "dizziness" and "headache," and clinically classifies it into several patterns, including liver and kidney yin deficiency, yin deficiency with internal heat, phlegm-dampness accumulation, and phlegm-blood stasis obstructing the meridians. TCM clinically often classifies hypertension as liver and kidney yin deficiency or yin deficiency with internal heat, commonly employing methods of nourishing yin and reducing fire, and calming the liver and suppressing yang. Formulas such as Zhi Bai Di Huang Wan and Tian Ma Gou Teng Yin are frequently used with modifications. While yin-nourishing and fire-reducing formulas can temporarily improve symptoms like yin deficiency with internal heat, dizziness, facial flushing, irritability, and insomnia, modern research indicates that these formulas are often greasy and cold in nature. Long-term use can easily impair the spleen, promote dampness, generate phlegm, and worsen phlegm-dampness stagnation. Furthermore, yin-nourishing herbs primarily focus on tonification and cannot improve peripheral microvascular stenosis or microcirculatory disorders, making it difficult to block the pathological cycle of abnormal activation of the hypothalamus-sympathetic-cardiac axis. They can only symptomatically improve the superficial symptoms of yin deficiency with internal heat, and have limited efficacy for phlegm-dampness obstruction type hypertension. They also have drawbacks such as slow onset of action, easy recurrence, and the potential for long-term dampness accumulation and spleen stagnation.

[0007] In Western medicine, diuretics, calcium channel blockers, beta-blockers, and sympathetic nerve inhibitors are commonly used to lower blood pressure. Among these, diuretics are the most widely used, achieving short-term blood pressure reduction by promoting renal sodium and water excretion and reducing blood volume. However, modern clinical research has confirmed that diuretics only act on fluid volume regulation and cannot improve the core problems of systemic peripheral microcirculation narrowing and phlegm and blood stasis. Long-term use can easily lead to hypokalemia, electrolyte imbalance, elevated blood sugar and lipids, and abnormal uric acid metabolism, inducing hyperuricemia and gout. At the same time, diuretics reflexively activate the sympathetic nervous system, stimulating the hypothalamus-sympathetic-cardiac axis to continuously excite, aggravating vasoconstriction and microcirculatory disorders, further increasing the compensatory pumping load on the heart, easily causing rebound blood pressure, unstable fluctuations, and even increasing the risk of refractory hypertension and myocardial hypertrophy. It treats the symptoms but not the root cause, and its long-term safety is poor.

[0008] With the modern diet being rich in fatty and sweet foods and the sedentary lifestyle, phlegm-dampness accumulation, phlegm-blood stasis obstructing the meridians, and microcirculatory disorders have become important pathogenic mechanisms of hypertension. Existing phlegm-resolving and blood-activating compound formulas for lowering blood pressure often simply focus on strengthening the spleen and resolving phlegm or promoting blood circulation and removing blood stasis. They lack a comprehensive design that warms the spleen and regulates qi, relieves spasms and unblocks the meridians, improves peripheral microvascular stenosis, regulates hypothalamic-sympathetic-cardiac axis homeostasis, and reduces the compensatory load on the heart. Therefore, they are insufficient to fundamentally block the pathological cycle of phlegm-dampness stasis obstruction – peripheral ischemia – central overactivation – cardiac compensatory blood pressure increase, resulting in long treatment cycles and easy recurrence of blood pressure.

[0009] Modern TCM clinical research shows that excessive phlegm and dampness can directly increase blood viscosity and slow blood flow. The sticky phlegm obstructs the circulation of blood throughout the body, causing peripheral microcirculation perfusion disorders. Due to the internal generation of phlegm and dampness in the body, the phlegm and dampness are sticky and stagnant, blocking the blood vessels and directly hindering normal blood flow, resulting in obstructed microcirculation perfusion. The normal capillary diameter in the human body is 6-9μm, but after phlegm and dampness blockage, it can constrict to 3-5μm, significantly increasing peripheral vascular resistance. The distal nerve endings in the human body have the longest blood supply pathways and the richest capillary distribution, making them the most prominent sites for ischemia, hypoxia, and nutrient deficiency. The peripheral nerves transmit ischemic signals to the hypothalamus's blood pressure regulation center via afferent nerves. The hypothalamus-sympathetic axis is activated, prompting the heart to compensate by increasing its pumping frequency and pressure to forcibly ensure blood supply to distal tissues. Long-term compensatory pumping eventually leads to persistent hypertension, forming a complete pathological closed loop: phlegm and dampness obstruction → blood flow obstruction → insufficient blood supply to distal nerve endings → hypothalamic central regulation → cardiac compensatory blood pressure increase → persistent hypertension.

[0010] Modern pharmacological studies and clinical literature confirm that the Chinese medicinal materials used in this invention all have clear antihypertensive pharmacological effects: nutmeg volatile oil can inhibit sympathetic nerve excitation, dilate peripheral arterioles, improve peripheral microcirculation, reduce blood viscosity, and regulate the activity of the hypothalamus blood pressure center; the active components of Allium macrostemon can dilate systemic microvessels, inhibit platelet aggregation, reduce peripheral vascular resistance, and improve blood rheological parameters; amomum villosum volatile oil can regulate the homeostasis of the hypothalamus-sympathetic-cardiac axis, dilate capillaries, and reduce vascular lipid and phlegm deposition; peach... The extract of safflower can dilate narrowed microvessels in the distal extremities, restore normal blood vessel diameter, and improve peripheral microcirculation perfusion; safflower yellow pigment can resist thrombosis, improve hemodynamics, accelerate blood flow, and reduce blood flow resistance; platycodon saponins can reduce blood viscosity, inhibit the deposition of phlegm-like substances on the vascular wall, and clear blood vessels; imperatorin in angelica can act on the hypothalamic blood pressure regulation center, calm the central nervous system, and inhibit neurogenic abnormal pressor reflex; volatile oil from tangerine peel can regulate blood lipids, dilate peripheral blood vessels, reduce phlegm and dampness, and relieve blood stasis. Based on the above pathological mechanisms and modern pharmacological evidence, this invention provides a traditional Chinese medicine composition that targets phlegm, unblocks blood vessels, regulates the homeostasis of the central-cardiac-peripheral microcirculation, and is safe and long-lasting in improving hypertension, thus overcoming the shortcomings of existing technologies. Summary of the Invention

[0012] Purpose of the invention

[0013] To address the shortcomings of existing hypertension treatment techniques, such as insufficient targeting of pathogenesis, limited efficacy, poor safety with long-term use, and inability to fundamentally improve phlegm-dampness obstruction of blood and peripheral ischemia, or block the hypothalamic-mediated compensatory blood pressure-raising pathological cycle, this invention provides a traditional Chinese medicine composition for improving hypertension. With phlegm-resolving, dampness-removing, blood-activating, and meridian-clearing as its core treatment principles, this composition resolves phlegm-dampness obstruction in the meridians, clears blood vessels, ensures normal blood circulation, improves distal blood supply to nerve endings, eliminates ischemic feedback signals, stabilizes hypothalamic blood pressure regulation function, and reduces compensatory cardiac pumping pressure. It addresses the root cause of phlegm-dampness obstruction-type hypertension while achieving safe, gentle, and long-term efficacy.

[0014] Technical solution

[0015] A traditional Chinese medicine composition for improving hypertension, comprising the following raw materials in parts by weight:

[0016] Nutmeg 5-10 parts, Allium macrostemon 8-15 parts, Amomum villosum 4-9 parts, Prunus persica 6-12 parts, Carthamus tinctorius 5-10 parts, Platycodon grandiflorus 7-13 parts, Angelica dahurica 6-11 parts, Citrus reticulata 8-14 parts.

[0017] The preferred formulation consists of the following parts by weight of active pharmaceutical ingredients:

[0018] Nutmeg 7 parts, Allium macrostemon 12 parts, Amomum villosum 6 parts, Prunus persica 9 parts, Carthamus tinctorius 7 parts, Platycodon grandiflorus 10 parts, Angelica dahurica 8 parts, Citrus reticulata 11 parts.

[0019] Preparation method

[0020] 1. Weigh each ingredient according to the above-mentioned weight proportions, remove impurities, clean them thoroughly, and dry them for later use;

[0021] 2. Grind the peach kernels and safflower into powder, cut the remaining herbs into sections, mix them together, and soak in purified water for 30-60 minutes;

[0022] 3. First decoction: Add 8-10 times the total weight of the medicinal materials to purified water, bring to a boil over high heat, then simmer over low heat for 40-60 minutes, filter to obtain the decoction;

[0023] 4. Second decoction: Add 5-7 times the total weight of the medicinal materials to purified water, simmer over low heat for 30-40 minutes, and filter to obtain the decoction;

[0024] 5. Combine the decoctions from the two decoctions and concentrate them into a clear paste with a relative density of 1.05-1.15. Depending on the usage requirements, prepare it into an oral liquid, decoction, or granules.

[0025] Compatibility Pharmacological Mechanism

[0026] The formulation of this invention closely addresses the core pathogenesis of phlegm-dampness obstruction, impaired blood circulation, peripheral ischemia, hypothalamic regulation, and cardiac compensatory blood pressure increase. It combines modern research in both traditional Chinese and Western medicine to achieve an organic integration of traditional Chinese medicine compatibility with modern pathology.

[0027] 1. Dried tangerine peel, nutmeg, and amomum: warm the spleen and regulate qi, dry dampness and resolve phlegm, block the internal generation of phlegm and dampness from the source, dissolve viscous phlegm and turbidity in the meridians, reduce the deposition on the blood vessel walls, dredge the blood vessels to ensure normal blood flow, and reduce blood viscosity; among them, nutmeg and amomum can target and regulate the homeostasis of the hypothalamus-sympathetic nerve-heart axis, avoid abnormal activation of the central nervous system, and reduce the compensatory pumping load of the heart.

[0028] 2. Allium macrostemon and Platycodon grandiflorus: promote Yang and dissipate stagnation, regulate Qi, dilate peripheral microvessels, reduce blood viscosity, relieve blood flow resistance caused by phlegm and dampness, improve systemic microcirculation perfusion, clear blockages in the meridians, reduce peripheral vascular resistance, and reduce cardiac ejection load.

[0029] 3. Angelica dahurica: It dries dampness and resolves phlegm, clears the head and eyes, targets the hypothalamus blood pressure regulation center, calms the central nervous system, inhibits abnormal blood pressure feedback caused by peripheral ischemia, stabilizes central regulatory function, and relieves dizziness and headache caused by hypertension.

[0030] 4. Peach kernel and safflower: promote blood circulation, clear blockages, gently dilate narrowed capillaries, restore blood vessels narrowed to 3-5μm to a normal diameter of 6-9μm, specifically improve blood and oxygen supply to the most distal nerve endings, eliminate peripheral ischemia signals, block abnormal activation of the hypothalamus-sympathetic axis, and relieve the compensatory increase in heart pumping frequency and pressure.

[0031] When used together, these herbs work synergistically to resolve phlegm and dampness, promote blood circulation and unblock meridians, improve peripheral blood supply, stabilize hypothalamic central regulation, alleviate cardiac compensatory load, and stabilize blood pressure. They comprehensively block the pathological loop of hypertension caused by phlegm and dampness obstructing blood flow, thus achieving root-cause treatment of hypertension caused by phlegm and dampness obstruction.

[0032] Specific Examples, Clinical Applications, Typical Cases

[0033] Case 1

[0034] The patient was a 56-year-old obese male with a history of consuming rich and fatty foods and a sedentary lifestyle. His chief complaint was dizziness, headache, general heaviness, and numbness and coldness in the extremities for over six months. His self-measured blood pressure fluctuated between 155 / 98 mmHg and 162 / 102 mmHg, leading to a clinical diagnosis of essential hypertension. He had previously taken Western antihypertensive medications, but his blood pressure fluctuated significantly and was prone to rebound, accompanied by chest tightness, excessive phlegm, abdominal distension, and heaviness in the limbs. Traditional Chinese medicine diagnosis indicated internal accumulation of phlegm and dampness, obstruction of the meridians, and impaired peripheral microcirculation, inducing abnormal excitation of the hypothalamus-sympathetic-cardiac axis and compensatory cardiac hypertensive activity.

[0035] The patient was given the preferred formulation of traditional Chinese medicine, taken as a conventional decoction, one dose daily, taken warm in the morning and evening, for 8 consecutive weeks. After the intervention, the patient's symptoms of dizziness, headache, general heaviness, chest tightness, and excessive phlegm completely subsided, and numbness and coldness in the extremities were significantly relieved; blood pressure remained stable at 128 / 82 mmHg to 135 / 85 mmHg. A 3-month follow-up after discontinuation of the medication showed no rebound in blood pressure, normalized spleen and stomach function, no significant adverse reactions, significant recovery of peripheral microcirculation, and a return to homeostasis of the compensatory hyperactivity of the hypothalamus and heart.

[0036] Case 2

[0037] The patient is a 52-year-old female with a preference for sweets and oily foods, a lack of exercise, and a family history of hypertension. She has experienced recurrent dizziness, a heavy feeling in the head, weakness in the limbs, and restless sleep for one year. Outpatient blood pressure measurements show fluctuations between 150 / 95 mmHg and 158 / 99 mmHg. She has intermittently taken Western medicine to lower her blood pressure with limited effectiveness; her blood pressure rises significantly after consuming oily foods or after exertion. Physical examination revealed a large, swollen tongue with a thick, greasy white coating, and a wiry, slippery pulse, indicating insufficient microcirculation perfusion in the extremities. Traditional Chinese medicine diagnosis indicates phlegm-dampness obstruction and poor blood circulation, with peripheral ischemia triggering abnormal activation of the hypothalamus, leading to compensatory cardiac pumping and elevated blood pressure.

[0038] The composition of this invention was administered orally in granule form twice daily for 12 consecutive weeks. After treatment, symptoms of heaviness in the head, dizziness, and weakness in the limbs completely disappeared, and sleep quality significantly improved; blood pressure was stably controlled between 125 / 80 mmHg and 132 / 83 mmHg, blood viscosity decreased, and the extremities warmed up and numbness disappeared. During a six-month follow-up, daily diet and lifestyle were unrestricted, blood pressure remained stable without fluctuation, phlegm-dampness constitution significantly improved, and no compensatory hypertension recurred.

[0039] Case 3

[0040] The patient is a 61-year-old male with a history of hyperlipidemia and peripheral microcirculatory disturbances, and a 3-year history of essential hypertension. His blood pressure fluctuates between 160 / 100 mmHg and 168 / 105 mmHg annually, and is difficult to control with two Western medicine antihypertensive drugs. He also experiences headache, tinnitus, copious and viscous sputum, heaviness in the lower limbs, and numbness and coldness in the fingertips. Western medical examination revealed peripheral capillary stenosis, abnormal hemorheological parameters, and increased peripheral vascular resistance. Traditional Chinese medicine diagnosis indicates phlegm-dampness obstruction of the collaterals, microvascular spasm and stenosis, and persistent peripheral ischemia leading to long-term activation of the hypothalamic-sympathetic-cardiac axis, resulting in compensatory hypertensive work by the heart.

[0041] Without adding any Western antihypertensive drugs, the patient simply took the decoction of the herbal composition of this invention, one dose daily, for 16 consecutive weeks. After the intervention, symptoms such as headache, tinnitus, thick phlegm, and heaviness in the lower limbs were completely relieved, numbness and coldness in the fingertips completely disappeared, and peripheral microcirculation blood supply returned to normal; blood pressure steadily decreased to 130 / 80 mmHg to 136 / 84 mmHg, eliminating the need for high-dose Western medicine maintenance. Follow-up examinations showed significant improvement in hemorheology and peripheral vascular resistance indicators, restoration of abnormal hypothalamic central regulation, and a substantial reduction in cardiac compensatory pumping load. Long-term follow-up showed stable blood pressure control with no recurrence.

[0042] Beneficial effects

[0043] 1. Scientific formulation: All 8 ingredients are commonly used Chinese medicinal herbs, with high safety and no obvious toxic side effects, suitable for long-term conditioning. The formulation is rigorous, with clear distinction between primary and secondary ingredients, addressing both the symptoms and the root cause.

[0044] 2. Clear mechanism: Combining modern Chinese and Western medicine pharmacological research, hypothalamic-sympathetic-cardiac axis regulation theory and microcirculation theory, the pharmacology of single herbs, the pathology of hypertension in Chinese and Western medicine and the limitations of treatment are all supported by authoritative literature. The pharmacology of the formulation is clear and the literature support is sufficient, which fully meets the requirements of patent examination norms.

[0045] 3. High practicality: The preparation process is simple and the dosage forms are diverse, which facilitates industrial production and clinical promotion;

[0046] 4. Precise Targeting: This invention targets the entire pathological chain of phlegm-dampness-microcirculation-central nervous system-heart, which is different from existing single phlegm-resolving, yin-nourishing or Western medicine antihypertensive solutions. The technical solution has outstanding novelty and inventiveness.

[0047] 5. Sufficient clinical evidence: Verified through application in multiple typical cases of phlegm-dampness obstruction type hypertension, the composition of this invention can significantly improve clinical symptoms, stably control blood pressure, repair peripheral microcirculation, and restore the compensatory state of the central nervous system and heart. It has definite curative effect, is safe and reliable, and has good prospects for clinical application and industrialization.

[0048] References

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Claims

1. A traditional Chinese medicine composition for improving hypertension, characterized in that, It is composed of the following raw materials in parts by weight: 5-10 parts nutmeg, 8-15 parts allium macrostemon, 4-9 parts amomum villosum, 6-12 parts peach kernel, 5-10 parts safflower, 7-13 parts platycodon grandiflorus, 6-11 parts angelica dahurica, and 8-14 parts dried tangerine peel.

2. The traditional Chinese medicine composition for improving hypertension according to claim 1, characterized in that, It is composed of the following raw materials in parts by weight: 7 parts nutmeg, 12 parts allium macrostemon, 6 parts amomum villosum, 9 parts peach kernel, 7 parts safflower, 10 parts platycodon grandiflorus, 8 parts angelica dahurica, and 11 parts dried tangerine peel.

3. A method for preparing a traditional Chinese medicine composition for improving hypertension as described in claim 1 or 2, characterized in that, Includes the following steps: (1) Weigh each raw material according to the weight, remove impurities, wash and dry; (2) Crush the peach kernels and safflower, cut the remaining medicinal materials into sections, mix them together and soak them in water for 30-60 minutes; (3) Add water for the first decoction. The amount of water should be 8-10 times the total weight of the medicinal materials. After boiling, simmer for 40-60 minutes and then filter the liquid. (4) Add water for the second decoction. The amount of water should be 5-7 times the total weight of the medicinal materials. Simmer over low heat for 30-40 minutes and then filter the liquid. (5) Combine the decoctions from the two decoctions and concentrate them to make oral liquid, decoction or granules.

4. The use of the traditional Chinese medicine composition for improving hypertension as described in claim 1 or 2 in the preparation of a drug for treating hypertension caused by phlegm-dampness stagnation.