Traditional Chinese medicine composition for treating IgA nephropathy with deficiency of both qi and yin and heat toxin invading throat, preparation method and application thereof

Abstract

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating IgA nephropathy of the type of deficiency of both qi and yin and invasion of heat toxin into the throat as well as a preparation method and application thereof. The traditional Chinese medicine composition comprises ginseng, lotus leaves, momordica grosvenori, burdock roots, platycodon grandiflorum, fat sea, lilies and white monodesma, wherein the mass ratio of the ginseng, lotus leaves, momordica grosvenori, burdock roots, platycodon grandiflorum, fat sea, lilies and white monodesma is (1-2):(0.5-1.5):(1-2):(0.5-1.5):(0.4-1.4):(0.4-1.4):(0.6-1.6):(0.6-1.6). Clinical tests show that the traditional Chinese medicine composition can not only significantly improve the symptoms of IgA nephropathy such as shortness of breath, lazy speech, soreness of the waist and knees, spontaneous sweating, hot hands and feet, headache and the like of patients with IgA nephropathy of the type of deficiency of both qi and yin and invasion of heat toxin into the throat, but also significantly improve the symptoms of throat discomfort such as sore throat, dry throat, throat itching, cough, expectoration, foreign body sensation in the throat and the like, and has good safety.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating IgA nephropathy of qi and yin deficiency and heat toxicity invading the pharynx, as well as a preparation method and application thereof. Background Art

[0002] IgA nephropathy is the most common primary glomerulitis in my country and the most common cause of end-stage renal disease. 15% to 20% of IgA nephropathy patients develop end-stage renal failure within 10 years of diagnosis, and 30% to 50% within 20 years of diagnosis. Modern medicine has varying understandings of the pathogenesis of IgA nephropathy, and its treatment does not advocate the use of hormones or immunosuppressants. Currently, there is no specific treatment. The mucosa of patients with IgA nephropathy is highly sensitive to pathogens. Excessive secretion of IgA1 after tonsil infection is a key step in the initiation of IgA nephropathy. Pharyngeal inflammation can trigger acute exacerbations of IgA nephropathy. Therefore, treating pharyngeal inflammation is a crucial part of preventing and treating IgA nephropathy.

[0003] Traditional Chinese medicine emphasizes on syndrome differentiation and treatment. Traditional Chinese medicine will carry out syndrome differentiation and treatment according to the different clinical manifestations of IgA nephropathy patients, and has certain advantages in the treatment of IgA nephropathy. Although there are many throat-clearing drugs in clinical practice, it is difficult to improve the symptoms of IgA nephropathy such as shortness of breath, laziness, soreness of waist and knees, spontaneous sweating, hot palms and soles, and headache in patients with IgA nephropathy using throat-clearing drugs alone; in addition, for the symptoms of throat discomfort such as sore throat, dry throat, itchy throat, cough, sputum, and foreign body sensation in patients with IgA nephropathy of qi and yin deficiency and heat-toxicity in the throat, the therapeutic effect of existing throat-clearing drugs is not ideal. Therefore, it is necessary to develop a Chinese medicine composition that can effectively treat the symptoms of IgA nephropathy of qi and yin deficiency and heat-toxicity in the throat and the accompanying throat discomfort symptoms. Summary of the Invention

[0004] The first purpose of the present invention is to provide a traditional Chinese medicine composition for treating IgA nephropathy of qi and yin deficiency and heat toxicity in the pharynx. The second purpose of the present invention is to provide a method for preparing the traditional Chinese medicine composition. The third purpose of the present invention is to provide an application of the traditional Chinese medicine composition.

[0005] According to a first aspect of the present invention, a traditional Chinese medicine composition for treating IgA nephropathy of qi and yin deficiency and heat-toxic invading pharynx type is provided, wherein the raw materials of the composition include: ginseng, lotus leaf, momordica grosvenori, burdock root, platycodon, sterculia lychnophora, lily, and cogongrass root, wherein the mass ratio of ginseng, lotus leaf, momordica grosvenori, burdock root, platycodon, sterculia lychnophora, lily, and cogongrass root is (1-2): (0.5-1.5): (1-2): (0.5-1.5): (0.4-1.4): (0.4-1.4): (0.6-1.6): (0.6-1.6).

[0006] The present invention believes that the root cause of IgA nephropathy is deficiency of both Qi and Yin, and its symptoms are exogenous wind-heat. When the wind-heat evil is felt, symptoms of IgA nephropathy such as shortness of breath, laziness to speak, soreness of waist and knees, spontaneous sweating, hot palms and soles, headache, as well as symptoms of throat discomfort such as sore throat, dry throat, itchy throat, cough, sputum, and foreign body sensation in the throat appear.

[0007] In the Chinese medicine composition of the present invention, ginseng replenishes qi and strengthens the body, nourishes vital energy, enters the lung and spleen meridians, and can replenish the qi of the lung and spleen, and is the main drug. The four herbs of burdock root, platycodon, pteridophyte and momordica grosvenori are used together to have the effects of relieving sore throat, clearing away heat and moistening the lungs, and are collectively the ministerial drugs. With lily and imperata root, the two can nourish yin and moisten dryness, clear away heat and detoxify, and promote diuresis and quench thirst. A small amount of lotus leaf is used as an adjuvant drug, which has the fragrance of raising yang, strengthening the spleen and removing dampness, and preventing excessive damage to the spleen and stomach due to coldness. The whole prescription plays the effects of clearing heat and relieving sore throat, replenishing qi and nourishing yin, and can not only significantly improve the IgA nephropathy symptoms such as shortness of breath, laziness, soreness of waist and knees, spontaneous sweating, hot palms and soles, headache, etc. in patients with qi and yin deficiency and heat-toxic invading throat type IgA nephropathy, but can also significantly improve the symptoms of throat discomfort such as sore throat, dry throat, itchy throat, cough, expectoration, and foreign body sensation in the throat.

[0008] The raw material sources of the present invention are as follows:

[0009] Ginseng: The dried root of Panax ginseng (Camey) in the Araliaceae family. Cultivated ginseng is called "garden ginseng," while wild ginseng is called "mountain ginseng." It has a sweet, slightly bitter, neutral flavor. It enters the spleen, lung, and heart meridians.

[0010] Lotus leaf: The leaves of the perennial herbaceous plant Nelumbo nucifera, Nelumbo nucifera. Bitter, neutral. Activates the Liver, Spleen, and Stomach meridians.

[0011] Momordica grosvenori: The dried fruit of the Cucurbitaceae plant Momordica grosvenori. It is sweet and cool, and enters the lung and large intestine meridians.

[0012] Burdock root: The root of the dicotyledonous plant Burdock (Asteraceae). Bitter and cold. Enters the Lung, Heart, and Liver meridians.

[0013] Platycodon grandiflorum (Jacq.) A.DC. (Campanaceae) is a plant that originates from the dried root. It has a bitter, pungent, neutral flavor. It enters the Lung meridian.

[0014] Pterocarya dahurica: Dried mature seeds of the plant Pterocarya dahurica (Sterculiaceae). Sweet in flavor, cold in nature. Enters the lung and large intestine meridians.

[0015] Lily: The dried fleshy scale leaves of Lilium lancifolium Thunb., Lilium brownii F.E. Brown var. viridulum Baker, or Lilium pumilum DC. (Liliaceae). Sweet, slightly bitter, and slightly cold. Activates the Heart and Lung meridians.

[0016] Imperata cylindrica root: The rhizome of Imperata cylindrica Beauv. var. major (Nees) CE Hubb., a plant of the Poaceae family. It is cold in nature and sweet in flavor. It enters the lung, stomach, and bladder meridians.

[0017] In some embodiments, the mass ratio of ginseng, lotus leaf, momordica grosvenori, burdock root, platycodon, sterculia lychnophora, lily, and imperata rhizome is 1.5:1:1.5:1:0.9:0.9:1.1:1.1.

[0018] In some embodiments, the Imperata rhizome is fresh Imperata rhizome.

[0019] In some embodiments, the dosage form of the Chinese medicine composition is tea, granules, decoction, powder, tablet, pill or capsule.

[0020] In some embodiments, a medically acceptable excipient is also included.

[0021] According to a second aspect of the present invention, a method for preparing the above-mentioned Chinese medicine composition is provided. When the Chinese medicine composition is in the form of a tea, the preparation method comprises the following steps:

[0022] After washing the raw materials, add 2-3 times the weight of water and soak for 30-60 minutes, then bake at 65±1°C for 2-3 hours to obtain dried medicinal materials; then grind the obtained dried medicinal materials, mix them evenly according to the ratio, put them into a sterilized packaging bag and seal them.

[0023] In some embodiments, the obtained dried medicinal materials are crushed and evenly mixed according to a ratio, and then placed in a sterilized non-woven bag and sealed to prepare a Chinese medicine tea bag.

[0024] According to a third aspect of the present invention, there is provided a use of the above-mentioned traditional Chinese medicine composition in the preparation of a medicament for treating IgA nephropathy of the qi and yin deficiency and heat-toxic invading pharynx type.

[0025] According to a fourth aspect of the present invention, there is provided a use of the above-mentioned Chinese medicine composition in the preparation of a medicament for treating throat discomfort. Specifically, the symptoms of throat discomfort include at least one of sore throat, dry throat, itchy throat, cough, expectoration, and foreign body sensation in the throat.

[0026] The beneficial effects of the present invention include:

[0027] Clinical trials have shown that the Chinese medicine composition of the present invention can not only significantly improve the symptoms of IgA nephropathy such as shortness of breath, laziness to speak, soreness of the waist and knees, spontaneous sweating, hot palms and soles, and headache in patients with qi and yin deficiency and heat-toxic invading throat type IgA nephropathy, but can also significantly improve the symptoms of throat discomfort such as sore throat, dry throat, itchy throat, cough, sputum, and foreign body sensation in the throat, and has good safety. DETAILED DESCRIPTION

[0028] The application will be further described in connection with specific examples. It is to be understood that the examples are only intended to better illustrate the application and do not limit the scope of the application. The process steps not disclosed in the examples are prior art. Unless otherwise specified, the raw materials below are commercially available.

[0029] Example 1

[0030] The preparation method of the Chinese medicine bag tea bag for treating IgA nephropathy with deficiency of both qi and yin and heat toxin invading throat in the embodiment includes the following steps:

[0031] The ginseng, lotus leaf, momordica grosvenori, burdock root, platycodon root, fat sea, lily, and fresh white ormon root are configured according to the mass ratio of 1:0.5:1:0.5:0.4:0.4:0.6:0.6. After the native medicinal materials are selected, the medicinal materials are cleaned and soaked in 3 times the weight of water for about 50 min, and then baked at 65±1℃ for about 3 h to obtain dried medicinal materials. The dried medicinal materials are crushed, mixed according to the ratio, and then sealed in a non-woven bag after sterilization, 10 g per bag. When taken, one bag is taken once a day.

[0032] Example 2

[0033] The preparation method of the Chinese medicine bag tea bag for treating IgA nephropathy with deficiency of both qi and yin and heat toxin invading throat in the embodiment includes the following steps:

[0034] The ginseng, lotus leaf, momordica grosvenori, burdock root, platycodon root, fat sea, lily, and fresh white ormon root are configured according to the mass ratio of 2:1.5:2:1.5:1.4:1.4:1.6:1.6. After the native medicinal materials are selected, the medicinal materials are cleaned and soaked in 3 times the weight of water for about 40 min, and then baked at 65±1℃ for about 2.5 h to obtain dried medicinal materials. The dried medicinal materials are crushed, mixed according to the ratio, and then sealed in a non-woven bag after sterilization, 10 g per bag. When taken, one bag is taken once a day.

[0035] Example 3

[0036] The preparation method of the Chinese medicine bag tea bag for treating IgA nephropathy with deficiency of both qi and yin and heat toxin invading throat in the embodiment includes the following steps:

[0037] Prepare ginseng, lotus leaf, monk fruit, burdock root, platycodon grandiflorum, pistachio dahurica, lily bulb, and fresh Imperata cylindrica root in a mass ratio of 1.5:1:1.5:1:0.9:0.9:1.1:1.1. Select authentic herbs, clean them, soak them in twice their weight of water for approximately 30 minutes, and then bake them at 65±1°C for approximately 2 hours to obtain dried herbs. The dried herbs are then pulverized, mixed uniformly according to the ratio, and sealed in a sterilized non-woven bag (10g per bag). Take one bag once daily for three months.

[0038] Of course, in actual application, the mass ratio of the raw medicinal materials of the Chinese medicine tea bag of the present invention can be adjusted appropriately within a range. For example, ginseng, lotus leaf, momordica grosvenori, burdock root, platycodon, sterculia lychnophora, lily, and cogongrass root are configured according to a mass ratio of 1.2:0.5:1.2:0.8:0.6:0.6:0.8:0.8; for example, ginseng, lotus leaf, momordica grosvenori, burdock root, platycodon, sterculia lychnophora, lily, and cogongrass root are configured according to a mass ratio of 1.5:0.6:1.5:1:0.8:0.8:1:1, and so on.

[0039] Next, to illustrate the therapeutic effect of the Chinese medicine composition of the present invention on IgA nephropathy of Qi and Yin deficiency and heat toxicity, the following clinical trials were conducted using the Chinese medicine tea bag prepared in Example 1.

[0040] 1. Test subjects

[0041] (1) According to the diagnostic criteria for IgA nephropathy described by KDIGO in 2012 (pathological findings on renal biopsy are a necessary diagnostic condition):

[0042] ①Clinical manifestations: paroxysmal gross hematuria or microscopic hematuria, with or without proteinuria;

[0043] ② Laboratory examination: Some patients may have elevated serum IgA;

[0044] ③ Renal biopsy: Light microscopy primarily reveals diffuse mesangial cell proliferation and increased mesangial matrix. Electron microscopy, in addition to the aforementioned findings, may also reveal large, electron-dense deposits. Immunofluorescence reveals diffuse, granular or clumpy deposits of immunoglobulins, primarily IgA, in the mesangial region. Furthermore, various secondary glomerular diseases characterized by predominantly IgA deposition should be excluded, such as purpuric nephritis, hepatitis B-related nephritis, and lupus nephritis.

[0045] (2) TCM syndrome diagnostic criteria

[0046] TCM syndrome diagnosis: Refer to the "Practice Guide for Western Diagnosis and TCM Dialectical Typing of IgA Nephropathy" compiled by the Kidney Disease Committee of the Chinese Association of Integrative Medicine, which includes Qi and Yin Deficiency, Wind-Heat Exogenous Syndrome, "Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine", and the typing standard of Qi and Yin Deficiency, Heat-toxic Guest Throat Syndrome based on clinical experience:

[0047] ①Main symptoms: shortness of breath, soreness of waist and knees, sweating, night sweats, hot hands and feet, sore throat (including swollen, enlarged, or even yellowish pus, or throat wall red), red or microscopic hematuria.

[0048] ②Secondary symptoms: pale complexion, headache, cough, dry mouth, and susceptibility to cold.

[0049] ③Tongue and pulse: pale or pale red tongue, thin or little fur, and slow or thin or thin and weak pulse.

[0050] Meet the diagnostic criteria for IgA nephropathy, and have 2 main symptoms and 2 secondary symptoms, combined with tongue and pulse.

[0051] (3) Inclusion criteria:

[0052] ① Age 18-80 years old;

[0053] ② Pathological biopsy diagnosis of IgA nephropathy;

[0054] ③ Symptoms of upper respiratory tract infection such as sore throat, throat swelling, dry throat, hoarseness, etc., meet the TCM syndrome of Qi and Yin deficiency, and heat-toxic throat;

[0055] ④ Sign the informed consent form.

[0056] (4) Exclusion criteria:

[0057] ① Combined with other autoimmune diseases;

[0058] ② Combined with other serious diseases of other organs;

[0059] ③ People with mental disorders;

[0060] ④ Pregnant or lactating women;

[0061] ⑤ Participants in other studies.

[0062] Using randomized controlled method, referring to the above criteria, subjects meeting the criteria were randomly divided into control group and test group. 23 people in the control group and 23 people in the test group.

[0063] 2. Test method

[0064] Basic treatment: Western medicine refers to the "KDIGO Clinical Practice Guidelines: Management of Glomerular Diseases" published in 2021, and provides diet, life management, blood pressure control and symptomatic support treatment.

[0065] Dietary management: strict salt restriction, low-protein diet, weight control, smoking cessation and alcohol restriction, etc.

[0066] Life management: regular work and rest schedule, adequate sleep, proper exercise and other lifestyle management.

[0067] Control blood pressure: The blood pressure standard is: when urine protein is greater than 0.3g / d, the recommended blood pressure control target is less than 130 / 80mmHg; when urine protein is greater than 1g / d, the blood pressure control target is less than 125 / 75mmHg.

[0068] Symptomatic treatment: timely correction of water, electrolyte and acid-base imbalances, diuresis and swelling reduction, anticoagulation, lipid regulation and other symptomatic supportive treatments.

[0069] (1) Control group: Basic treatment + ordinary tea bags (Zhengshan Xiaozhong, note: black tea has anti-inflammatory effects) for oral administration. Each bag is 5g, and one bag should be brewed and taken warm half an hour after breakfast every day; the amount of water used for soaking is 300ml each time. Take one bag once a day for a total of 3 months.

[0070] (2) Experimental Group: Basic treatment plus oral administration of the Chinese medicine teabag prepared in Example 1. Each bag is 10g. One bag should be brewed and taken warm half an hour after breakfast daily. The amount of water used for each soak is 300ml. Take one bag once a day for a total of 3 months.

[0071] 3. Efficacy evaluation results

[0072] (1) Comparison of TCM symptom scores between the two groups before intervention showed that the two groups were well-balanced and comparable (P>0.05). Intra-group comparison of the two groups before and after intervention showed that the control group showed improvement in shortness of breath, laziness of speech, heat in the palms and soles, sore throat, dull complexion, and dry mouth, with statistically significant differences (P<0.05); the experimental group showed improvement in shortness of breath, laziness of speech, soreness of waist and knees, spontaneous sweating, heat in the palms and soles, sore throat, headache, cough, and dry mouth, with statistically significant differences (P<0.05). Inter-group comparison of the two groups after treatment showed that the experimental group showed more significant improvement in shortness of breath, laziness of speech, soreness of waist and knees, and sore throat, with statistically significant differences (P<0.05). The above results indicate that the discomfort symptoms of IgA nephropathy of qi and yin deficiency and heat toxicity in the pharynx were improved in both groups after intervention, but the improvement in the experimental group was more obvious. The results of the comparison of TCM symptom scores between the two groups before and after treatment are shown in Table 1.

[0073] Table 1 Comparison of TCM symptom scores between the two groups before and after treatment

[0074]

[0075]

[0076] Note: ① All TCM symptom scores were non-normal, and the Mann-Whitney U test was used, with the results described by M (P25, P75). * represents the comparison within the control group before and after treatment, P < 0.05; ※ The comparison between the experimental group before and after treatment was P < 0.05; # The comparison between the two groups after treatment is P < 0.05. ②The symptoms listed in the table are for IgA nephropathy of the Qi and Yin deficiency and heat-toxin invasion of the pharynx.

[0077] (2) The TCM symptom scores of the two groups before intervention were compared, and the two groups were balanced and comparable (P>0.05). The two groups were compared within the group before and after treatment. The TCM symptom scores of the two groups decreased significantly after treatment compared with those before treatment, and the difference was statistically significant (P<0.05). The TCM symptom scores of the two groups after treatment were compared between the groups. The TCM symptom scores of the experimental group decreased more significantly than those of the control group, and the difference was statistically significant (P<0.05). The above results show that after intervention, the discomfort symptoms of IgA nephropathy of Qi and Yin deficiency and heat toxicity in the pharynx type in both groups were improved, but the symptoms of the experimental group were more significantly improved. The results of the comparison of TCM symptom scores of the two groups before and after treatment are shown in Table 2.

[0078] Table 2 Comparison of TCM symptom scores between the two groups before and after treatment

[0079]

[0080] Note: ① The TCM symptom scores of both groups were normally distributed, described by x±s. * indicates the comparison within the control group before and after treatment, P<0.05; ※ represents the intra-group comparison before and after treatment, P < 0.05; # The comparison between the control group and the experimental group after treatment is P < 0.05. ② TCM symptom score refers to the sum of the scores of each symptom listed in Table 1.

[0081] (3) Before the intervention, the VAS scores of the two groups were compared. There was no statistical difference between the two groups (P>0.05), and the two groups were balanced and comparable. The VAS symptom scores of the two groups were compared within the group before and after the intervention. The control group showed that pharyngeal pain and dry throat were improved before and after treatment, and the differences were statistically significant (P<0.05); the experimental group showed that pharyngeal pain, dry throat, itchy throat, cough, sputum, and foreign body sensation in the throat were improved before and after treatment, and the differences were statistically significant (P<0.05). After the treatment, the two groups were compared between the two groups. The improvement of pharyngeal pain and foreign body sensation in the experimental group was more obvious than that in the control group, and the difference was statistically significant (P<0.05). The above results show that the VAS scores of the symptoms in both groups were improved after the intervention, but the improvement in the experimental group was more obvious. The changes in VAS scores before and after treatment in the two groups are shown in Table 3.

[0082] Table 3 Changes in VAS scores in the two groups before and after treatment

[0083]

[0084]

[0085] Note: ① All TCM symptom VAS scores were non-normal, and the Mann-Whitney U test was used, and the results were described by M (P25, P75). * represents the comparison within the control group before and after treatment, P < 0.05; ※ represents the intra-group comparison before and after treatment, P < 0.05; # The comparison between the control group and the experimental group after treatment is P < 0.05. ②The symptoms listed in the table are related to the throat.

[0086] 4. Safety evaluation results

[0087] One patient in the control group experienced insomnia after drinking the tea bag; this episode resolved after the tea was consumed earlier. No insomnia episodes occurred in the experimental group. Laboratory safety tests in both groups showed no significant abnormalities.

[0088] The above research results show that the Chinese medicine composition of the present invention can not only improve the symptoms of IgA nephropathy such as shortness of breath, laziness to speak, soreness of waist and knees, spontaneous sweating, hot palms and soles, and headache in patients with IgA nephropathy of qi and yin deficiency and heat-toxic invasion of the throat, but also improve the symptoms of throat discomfort such as sore throat, dry throat, itchy throat, cough, sputum, and foreign body sensation in the throat. It treats both the symptoms and the root cause by replenishing qi and nourishing yin, clearing away heat and detoxifying, and strengthening the body, and has good safety.

[0089] The above descriptions are only some specific embodiments of the present invention. For those skilled in the art, several modifications and improvements can be made without departing from the creative concept of the present invention, and these all fall within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating IgA nephropathy of Qi and Yin deficiency and heat toxicity, characterized in that: The raw materials are composed of ginseng, lotus leaf, monk fruit, burdock root, platycodon, sterculia lychnophora, lily and imperata root, among which the mass ratios of ginseng, lotus leaf, monk fruit, burdock root, platycodon, sterculia lychnophora, lily and imperata root are (1-2): (0.5-1.5): (1-2): (0.5-1.5): (0.4-1.4): (0.4-1.4): (0.6-1.6): (0.6-1.6).

2. The Chinese medicine composition according to claim 1, characterized in that The mass ratio of ginseng, lotus leaf, momordica grosvenori, burdock root, platycodon, sterculia lychnophora, lily and imperata root is 1.5:1:1.5:1:0.9:0.9:1.1:1.

1.

3. The Chinese medicine composition according to claim 1 or 2, characterized in that The Imperata rhizome is fresh Imperata rhizome.

4. The Chinese medicine composition according to claim 1 or 2, characterized in that The dosage form of the Chinese medicine composition is tea, granules, decoction, powder, tablets, pills or capsules.

5. The Chinese medicine composition according to claim 1 or 2, characterized in that Also included are medically acceptable excipients.

6. The method for preparing the Chinese medicine composition according to any one of claims 1 to 5, characterized in that: When the Chinese medicine composition is a tea, the preparation method thereof comprises the following steps: After washing the raw materials, add 2-3 times the weight of water and soak for 30-60 minutes, then bake at 65±1°C for 2-3 hours to obtain dried medicinal materials; then grind the obtained dried medicinal materials, mix them evenly according to the ratio, put them into a sterilized packaging bag and seal them.

7. The preparation method according to claim 6, characterized in that The obtained dried medicinal materials are crushed and evenly mixed according to a proportion, and then put into a sterilized non-woven bag and sealed to make a Chinese medicine tea bag.

8. Use of the Chinese medicine composition according to any one of claims 1 to 5 in the preparation of a medicament for treating IgA nephropathy of the qi and yin deficiency and heat-toxic invading pharynx type.

9. Use of the Chinese medicine composition according to any one of claims 1 to 5 in the preparation of a medicament for treating throat discomfort in patients with IgA nephropathy of the qi and yin deficiency and heat-toxic invasion of the throat type.

10. The use according to claim 9, characterized in that The symptoms of throat discomfort include at least one of sore throat, dry throat, itchy throat, cough, sputum, and foreign body sensation in the throat.

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