Method for monitoring abdominal aortic aneurysm change based on morphological segmentation

Abstract

The invention discloses a morphological segmentation-based abdominal aortic aneurysm change monitoring method, which comprises the following steps of 1, performing three-dimensional modeling on an abdominal aortic aneurysm based on a clinical image; 2, determining the positions of the proximal end tumor neck and the telecentric end tumor neck of the aneurysm through a clinical image or a three-dimensional model, obtaining the midpoints of the proximal end tumor neck and the telecentric end tumor neck of the aneurysm, and extracting the vertical distance between the two midpoints as the vertical length (L) of the aneurysm; 3, based on the obtained vertical length L of the aneurysm, the abdominal aortic aneurysm is vertically and equally divided into n sections, and the length of each section is L / n; 4, obtaining the surface area and the volume of each section of the n sections, and obtaining various morphological parameters at different sections through calculation; and 5, quantitatively monitoring and evaluating the morphological change development of each section of the abdominal aortic aneurysm in combination with the result of the step 4.

Description

Technical Field

[0001] The invention belongs to the field of abdominal aortic aneurysm assessment, and in particular relates to a method for monitoring abdominal aortic aneurysm changes based on morphological segmentation. Background Art

[0002] The monitoring method of the risk of abdominal aortic aneurysm (AAA) rupture has always been a very concerned issue in clinical practice. Among them, morphology has been widely used in clinical monitoring of AAA changes and development and assessing the risk of aneurysm rupture. Currently, the most common morphological indicator for assessing the risk of AAA rupture is the maximum size of the aneurysm, that is, the maximum diameter of the entire aneurysm. Clinically, when the maximum diameter of the AAA is greater than 5cm (female) or greater than 5.5cm (male), the aneurysm is considered to have a high risk of rupture and surgical intervention should be performed. Similarly, there are other morphological methods for monitoring AAA rupture, including aneurysm neck size, aneurysm eccentricity, aneurysm growth rate, etc., but the application of these parameters is not as widespread as the maximum size of the aneurysm.

[0003] On the other hand, although the maximum size of AAA is widely used in clinical practice, a large number of investigations and studies have also found that some patients whose maximum size of AAA has not yet reached the surgical intervention indicator still have ruptures. This challenges the reliability of this method in assessing aneurysm rupture. The reason may be that the maximum size of AAA mainly focuses on a certain position in the overall morphology of AAA, and does not effectively monitor the morphology of other parts of the aneurysm. This makes this method of monitoring aneurysm morphology unable to fully reflect the morphological development of various parts of AAA, and other related morphological information of the aneurysm cannot be fully described by this single parameter. Considering that aneurysm rupture often occurs only at a local point, clinically monitoring the maximum size of AAA alone will make it difficult to capture local morphological changes in other parts of the aneurysm, and thus cannot effectively predict the risk of aneurysm rupture. Summary of the invention

[0004] In order to solve the above problems existing in the prior art, the present invention divides AAA into multiple segments, and then monitors the morphological parameters of each segment of the aneurysm wall, quantitatively evaluates the changes in the morphological parameters of each segment of the aneurysm wall, so as to effectively grasp the morphological development of each segment of the aneurysm, and provide a useful supplement for clinical monitoring of AAA growth changes and rupture risks. The technical solution adopted by the present invention is:

[0005] A method for monitoring changes of abdominal aortic aneurysm based on morphological segmentation, comprising the following steps:

[0006] Step 1: 3D modeling of abdominal aortic aneurysm based on clinical images;

[0007] Step 2: Determine the location of the proximal neck and the distal neck of the aneurysm through clinical images or three-dimensional models, obtain the midpoint of the proximal neck and the distal neck of the aneurysm, and extract the vertical distance between the two midpoints as the vertical length of the aneurysm (L);

[0008] Step 3: Based on the obtained vertical length L of the aneurysm, the abdominal aortic aneurysm is divided vertically into n segments, and the length of each segment is L / n;

[0009] Step 4: Obtain the surface area (SA) and volume (V) of each segment of the n segments, and obtain various morphological parameters at different segments through calculation;

[0010] Step 5: Combined with the results of step 4, quantitative monitoring and evaluation of the morphological changes and development of each segment of the abdominal aortic aneurysm are performed.

[0011] VSA a-b,i =SA b，i -SA a，i

[0012]

[0013] Among them, a and b represent two different follow-up visits, i represents the i-th segment in n segments, SA (Surface Area) represents the surface area, b,i Represents the next measurement value, SA a,i Represents the previous measurement value, VSA a-b,i (Variation of SA) means the change in the surface area of ​​the i-th segment of the abdominal aortic aneurysm during the two follow-up periods a and b, and its dimension is cm 2 When the value is greater than 0, it indicates that the surface area of ​​the AAA segment is increasing, the aneurysm wall is growing, the risk of aneurysm rupture is correspondingly increasing, and the patient's condition is deteriorating; when the value is less than 0, it indicates that the surface area of ​​the AAA segment is decreasing, the aneurysm wall is shrinking, the risk of aneurysm rupture is correspondingly decreasing, and the patient's condition is improving; the larger the absolute value of the value, the more unstable the patient's aneurysm is, and the more obvious the morphological changes are; the smaller the absolute value of the value, the more stable the patient's aneurysm is, and the less obvious the morphological changes are.

[0014] In addition, RSA a-b,i (Ratio of Surface Area) represents the ratio of the surface area of ​​the i-th segment of the abdominal aorta during the two follow-up periods a and b, which is a dimensionless parameter greater than 0. When the value is greater than 1, it indicates that the surface area of ​​the AAA segment is increasing, the aneurysm wall is growing, the risk of aneurysm rupture is correspondingly increasing, and the patient's condition is deteriorating; when the value is less than 1, it indicates that the surface area of ​​the AAA segment is decreasing, the aneurysm wall is shrinking, the risk of aneurysm rupture is correspondingly decreasing, and the patient's condition is improving; the greater the deviation of the value from 1, the more unstable the patient's aneurysm is, and the more obvious the morphological changes are; when the value is closer to 1, the more stable the patient's aneurysm is, and the less obvious the morphological changes are.

[0015] Finally, VSAY a-b,i Variation of Surface Area per Year means the annual variation of the surface area of ​​the i-th segment of the abdominal aortic aneurysm between the two follow-up visits a and b, and its dimension is cm 2 / year. When the value is greater than 0, it indicates that the surface area of ​​the AAA segment is increasing, the aneurysm wall is growing, the risk of aneurysm rupture is correspondingly increasing, and the patient's condition is deteriorating; when the value is less than 0, it indicates that the surface area of ​​the AAA segment is decreasing, the aneurysm wall is shrinking, the risk of aneurysm rupture is correspondingly decreasing, and the patient's condition is improving; the larger the absolute value of the value, the more unstable the patient's aneurysm is, and the more obvious the morphological changes are; the smaller the absolute value of the value, the more stable the patient's aneurysm is, and the less obvious the morphological changes are.

[0016] Furthermore, in step 4, it includes

[0017] VV a-b,i =V b,i -V a,i

[0018]

[0019] Among them, V (Volume) represents volume, VV a-b,i (Variation of Volume) means the change in the volume of the i-th segment of the abdominal aortic aneurysm during the two follow-up periods a and b, and its dimension is cm 3When the value is greater than 0, it indicates that the volume of the AAA segment is increasing, the aneurysm wall is growing, the risk of aneurysm rupture is correspondingly increasing, and the patient's condition is deteriorating; when the value is less than 0, it indicates that the volume of the AAA segment is decreasing, the aneurysm wall is shrinking, the risk of aneurysm rupture is correspondingly decreasing, and the patient's condition is improving; the larger the absolute value of the value, the more unstable the patient's aneurysm is, and the more obvious the morphological changes are; the smaller the absolute value of the value, the more stable the patient's aneurysm is, and the less obvious the morphological changes are.

[0020] In addition, RV a-b,i (Ratio of Volume) represents the ratio of the volume of the i-th segment of the abdominal aorta during the two follow-up periods a and b, which is a dimensionless parameter greater than 0. When the value is greater than 1, it indicates that the volume of the AAA segment is increasing, the aneurysm wall is growing, the risk of aneurysm rupture is correspondingly increasing, and the patient's condition is deteriorating; when the value is less than 1, it indicates that the volume of the AAA segment is decreasing, the aneurysm wall is shrinking, the risk of aneurysm rupture is correspondingly decreasing, and the patient's condition is improving; the greater the deviation of the value from 1, the more unstable the patient's aneurysm is, and the more obvious the morphological changes are; when the value is closer to 1, the more stable the patient's aneurysm is, and the less obvious the morphological changes are.

[0021] Finally, VVY a-b,i (Variation of Volume per Year) means the annual change in the volume of the i-th segment of the abdominal aortic aneurysm between the two follow-up periods a and b, and its dimension is cm 3 / year. When the value is greater than 0, it indicates that the volume of the AAA segment is increasing, the aneurysm wall is growing, the risk of aneurysm rupture is correspondingly increasing, and the patient's condition is deteriorating; when the value is less than 0, it indicates that the volume of the AAA segment is decreasing, the aneurysm wall is shrinking, the risk of aneurysm rupture is correspondingly decreasing, and the patient's condition is improving; the larger the absolute value of the value, the more unstable the patient's aneurysm is, and the more obvious the morphological changes are; the smaller the absolute value of the value, the more stable the patient's aneurysm is, and the less obvious the morphological changes are.

[0022] The beneficial effects of the present invention are:

[0023] First, the method introduced in this article is not mentioned in previous studies and is a new method for monitoring changes in aneurysm status introduced in this invention.

[0024] Secondly, this method is mainly based on the patient's clinical medical images and does not require other additional examinations. It is a non-invasive analysis technology.

[0025] Finally, this parameter is very intuitive when used clinically, and its changes can be directly used to describe changes in aneurysm status during different follow-up processes, which can effectively provide doctors with quantitative morphological references for clinical decision-making. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 Clinical images and three-dimensional model reconstruction during the follow-up of abdominal aortic aneurysm in the present invention, where (a) is four months before aneurysm rupture, (b) is one day before aneurysm rupture, and (c) is the day of aneurysm rupture.

[0027] Figure 2 It is a schematic diagram of the regional morphological parameters and segmentation method of abdominal aortic aneurysm in the present invention.

[0028] Figure 3 The morphological parameters related to the abdominal aortic aneurysm area during the two follow-up periods were statistically analyzed. DETAILED DESCRIPTION

[0029] The present invention will be further described below with reference to the accompanying drawings and the accompanying drawings.

[0030] In order to more clearly understand the above-mentioned purpose, features and advantages of the present invention, the present invention is described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be noted that the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

[0031] The terms “first”, “second”, “third”, etc. are only used for distinguishing descriptions and should not be understood as indicating or implying relative importance.

[0032] In the description of the present invention, it is also necessary to explain that, unless otherwise clearly specified and limited, the terms "set", "install", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0033] The specific implementation of the present invention is described in detail below in conjunction with the accompanying drawings. It should be understood that the specific implementation described here is only used to illustrate and explain the present invention, and is not used to limit the present invention.

[0034] Embodiment 1:

[0035] like Figure 1 and 2 As shown, a method for monitoring changes of abdominal aortic aneurysm based on morphological segmentation includes the following steps:

[0036] Step 1: 3D modeling of abdominal aortic aneurysm based on clinical images;

[0037] Step 2: Determine the location of the proximal neck and the distal neck of the aneurysm through clinical images or three-dimensional models, obtain the midpoint of the proximal neck and the distal neck of the aneurysm, and extract the vertical distance between the two midpoints as the vertical length of the aneurysm (L);

[0038] Step 3: Based on the obtained vertical length L of the aneurysm, the abdominal aortic aneurysm is divided vertically into n segments, and the length of each segment is L / n;

[0039] Step 4: Obtain the surface area (SA) and volume (V) of each segment of the n segments, and obtain various morphological parameters at different segments through calculation;

[0040] Step 5: Combined with the results of step 4, quantitative monitoring and evaluation of the morphological changes and development of each segment of the abdominal aortic aneurysm are performed.

[0041] Embodiment 2:

[0042] Based on Example 1, the step 4 includes

[0043] VSA a-b，i =SA b，i -SAa ，i

[0044] Where a and b represent two different follow-up visits, i represents the i-th segment in n segments, SA (Surface Area) represents the surface area, VSA represents the a-b,i (Variation of SA) means the change in the surface area of ​​the i-th segment of the abdominal aortic aneurysm during the two follow-up periods a and b, and its dimension is cm 2 When the value is greater than 0, it indicates that the surface area of ​​the AAA segment is increasing, the aneurysm wall is growing, the risk of aneurysm rupture is correspondingly increasing, and the patient's condition is deteriorating; when the value is less than 0, it indicates that the surface area of ​​the AAA segment is decreasing, the aneurysm wall is shrinking, the risk of aneurysm rupture is correspondingly decreasing, and the patient's condition is improving; the larger the absolute value of the value, the more unstable the patient's aneurysm is, and the more obvious the morphological changes are; the smaller the absolute value of the value, the more stable the patient's aneurysm is, and the less obvious the morphological changes are.

[0045] Embodiment 3:

[0046] Based on Example 2, the step 4 includes

[0047]

[0048] In addition, RSA a-b,i (Ratio of Surface Area) represents the ratio of the surface area of ​​the i-th segment of the abdominal aorta between the two follow-up periods a and b, and is a dimensionless parameter greater than 0. When the value is greater than 1, it indicates that the surface area of ​​the AAA segment is increasing, the aneurysm wall is growing, the risk of aneurysm rupture is correspondingly increasing, and the patient's condition is deteriorating; when the value is less than 1, it indicates that the surface area of ​​the AAA segment is decreasing, the aneurysm wall is shrinking, the risk of aneurysm rupture is correspondingly decreasing, and the patient's condition is improving; the greater the deviation of the value from 1, the more unstable the patient's aneurysm is, and the more obvious the morphological changes are; when the value is closer to 1, the more stable the patient's aneurysm is, and the less obvious the morphological changes are.

[0049] Embodiment 4:

[0050] Based on Example 3, the step 4 includes

[0051]

[0052] Finally, VSAY a-b,i Variation of Surface Area per Year means the annual variation of the surface area of ​​the i-th segment of the abdominal aortic aneurysm between the two follow-up visits a and b, and its dimension is cm 2 / year. When the value is greater than 0, it indicates that the surface area of ​​the AAA segment is increasing, the aneurysm wall is growing, the risk of aneurysm rupture is correspondingly increasing, and the patient's condition is deteriorating; when the value is less than 0, it indicates that the surface area of ​​the AAA segment is decreasing, the aneurysm wall is shrinking, the risk of aneurysm rupture is correspondingly decreasing, and the patient's condition is improving; the larger the absolute value of the value, the more unstable the patient's aneurysm is, and the more obvious the morphological changes are; the smaller the absolute value of the value, the more stable the patient's aneurysm is, and the less obvious the morphological changes are.

[0053] Embodiment 5:

[0054] Based on Example 1, the step 4 includes

[0055] VV a-b,i =V b,i -V a,i

[0056] Among them, V (Volume) represents volume, VV a-b,i (Variation of Volume) means the change in the volume of the i-th segment of the abdominal aortic aneurysm during the two follow-up periods a and b, and its dimension is cm 3When the value is greater than 0, it indicates that the volume of the AAA segment is increasing, the aneurysm wall is growing, the risk of aneurysm rupture is correspondingly increasing, and the patient's condition is deteriorating; when the value is less than 0, it indicates that the volume of the AAA segment is decreasing, the aneurysm wall is shrinking, the risk of aneurysm rupture is correspondingly decreasing, and the patient's condition is improving; the larger the absolute value of the value, the more unstable the patient's aneurysm is, and the more obvious the morphological changes are; the smaller the absolute value of the value, the more stable the patient's aneurysm is, and the less obvious the morphological changes are.

[0057] Embodiment 6:

[0058] Based on Example 5, the step 4 includes

[0059]

[0060] In addition, RV a-b,i (Ratio of Volume) represents the ratio of the volume of the i-th segment of the abdominal aorta during the two follow-up periods a and b, which is a dimensionless parameter greater than 0. When the value is greater than 1, it indicates that the volume of the AAA segment is increasing, the aneurysm wall is growing, the risk of aneurysm rupture is correspondingly increasing, and the patient's condition is deteriorating; when the value is less than 1, it indicates that the volume of the AAA segment is decreasing, the aneurysm wall is shrinking, the risk of aneurysm rupture is correspondingly decreasing, and the patient's condition is improving; the greater the deviation of the value from 1, the more unstable the patient's aneurysm is, and the more obvious the morphological changes are; when the value is closer to 1, the more stable the patient's aneurysm is, and the less obvious the morphological changes are.

[0061] Embodiment 7:

[0062] Based on Example 6, the step 4 includes

[0063]

[0064] Finally, VVY a-b,i (Variation of Volume per Year) means the annual change in the volume of the i-th segment of the abdominal aortic aneurysm between the two follow-up periods a and b, and its dimension is cm 3 / year. When the value is greater than 0, it indicates that the volume of the AAA segment is increasing, the aneurysm wall is growing, the risk of aneurysm rupture is correspondingly increasing, and the patient's condition is deteriorating; when the value is less than 0, it indicates that the volume of the AAA segment is decreasing, the aneurysm wall is shrinking, the risk of aneurysm rupture is correspondingly decreasing, and the patient's condition is improving; the larger the absolute value of the value, the more unstable the patient's aneurysm is, and the more obvious the morphological changes are; the smaller the absolute value of the value, the more stable the patient's aneurysm is, and the less obvious the morphological changes are.

[0065] Embodiment 8:

[0066] On the basis of Example 1, Figure 3 As shown in the figure, we counted the relevant morphological parameters four months before rupture (follow-up 1) and one day before rupture (follow-up 2). We divided the abdominal aortic aneurysm of the patient into 10 segments (n=10). According to the statistical results of the patient, we can see that before the rupture of the abdominal aortic aneurysm, the surface area (SA) and volume (V) of the local segment of the patient changed significantly, and the most obvious change was between Segment 6 and Segment 8. In fact, the rupture of the patient's aneurysm was also located there. Similarly, we can observe that the patient's VSA and VV are both greater than 0. Considering that the interval between the two examinations is 4 months, VVY is also greater than 0. At the same time, RSA and RV are also greater than 1, especially reaching the maximum near Segment 6 to Segment 8, indicating that the local morphology of the aneurysm has changed significantly before rupture. It can be seen that the method introduced in the patent of this invention can effectively capture the differences in the local morphological changes of aneurysms and provide valuable reference for clinical monitoring of the development of aneurysm morphology.

[0067] The present invention is not limited to the above-mentioned optional implementation modes. Anyone can derive other various forms of products under the inspiration of the present invention. However, no matter what changes are made in the shape or structure, all technical solutions that fall within the scope defined by the claims of the present invention fall within the protection scope of the present invention.

Claims

1. A method for monitoring changes in abdominal aortic aneurysm based on morphological segmentation, characterized in that: The following steps are involved: Step 1: 3D modeling of abdominal aortic aneurysm based on clinical images; Step 2: Determine the location of the proximal neck and the distal neck of the aneurysm through clinical images or three-dimensional models, obtain the midpoint of the proximal neck and the distal neck of the aneurysm, and extract the vertical distance between the two midpoints as the vertical length of the aneurysm (L); Step 3: Based on the obtained vertical length L of the aneurysm, the abdominal aortic aneurysm is divided vertically into n segments, and the length of each segment is L / n; Step 4: Obtain the surface area (SA) and volume (V) of each segment of the n segments, and obtain various morphological parameters at different segments through calculation; Step 5: Combined with the results of step 4, quantitative monitoring and evaluation of the morphological changes and development of each segment of the abdominal aortic aneurysm are performed.

2. The method for monitoring abdominal aortic aneurysm changes based on morphological segmentation according to claim 1, characterized in that: In step 4, it includes VSA a-b,i =IN b,i -IN a,i Where a and b represent two different follow-up visits, i represents the i-th segment in n segments, SA (Surface Area) represents the surface area, VSA a-b,i (Variation of Surface Area) refers to the change in the surface area of ​​the i-th segment of the abdominal aortic aneurysm during the two follow-up periods a and b, and its dimension is cm 2 ; RSA a-b,i (Ratio of Surface Area) represents the ratio of the surface area of ​​the i-th segment of the abdominal aorta during the two follow-up periods a and b, which is a dimensionless parameter greater than 0; VSAY a-b,i Variation of Surface Area per Year means the annual variation of the surface area of ​​the i-th segment of the abdominal aortic aneurysm between the two follow-up visits a and b, and its dimension is cm 2 / year.

3. The method for monitoring abdominal aortic aneurysm changes based on morphological segmentation according to claim 1, characterized in that: In step 4, it includes VV a-b,i =V b,i -V a,i Among them, V (Volume) represents volume, VV a-b,i (Variation of Volume) means the change in the volume of the i-th segment of the abdominal aortic aneurysm during the two follow-up periods a and b, and its dimension is cm 3 ; RV a-b,i (Ratio of Volume) represents the ratio of the volume of the i-th segment of the abdominal aorta during the two follow-up periods a and b, which is a dimensionless parameter greater than 0; VY a-b,i (Variation of Volume per Year) means the annual change in the volume of the i-th segment of the abdominal aortic aneurysm during the two follow-up periods a and b, and its dimension is cm 3 / year.

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