A control method, device and medium for an artificial liver blood purification pipeline

Abstract

The application provides a control method, system, equipment, medium and program product of an artificial liver blood purification pipeline, and relates to the medical field.The method comprises the following steps: acquiring an instruction of turning on or off at least one component in the pipeline; and changing the flow direction of the plasma in the pipeline component according to the instruction.The method automatically controls the conduction and / or disconnection among the pipelines according to different types of treatment equipment, so as to control the flow direction of the blood and the plasma in the pipeline, realize the effect of automatically adapting to various treatment modes, overcome the defect that the currently used pipeline can only complete a single corresponding treatment mode, and comprehensively control the pipeline in an automatic mode, so that the steps of assembling multiple sets of pipelines are avoided, the probability of errors and pollution in the pipeline installation process is reduced, the medical cost is reduced, and the workload of medical staff is reduced.

Description

Technical Field

[0001] This invention relates to the field of intelligent medical care, and more specifically, to a control method, device, medium, and program product for an artificial liver blood purification pipeline. Background Technology

[0002] Artificial liver therapy is an important means of treating liver failure. Relevant guidelines and consensus statements all indicate that artificial liver therapy has a definite clinical effect. Its treatment principle is to use an extracorporeal circulation system to perform functions such as separation, replacement, adsorption, and substance exchange, temporarily replacing part of the liver function, removing harmful substances, supplementing essential substances, creating conditions for hepatocyte regeneration, and can also serve as a bridge to liver transplantation. Commonly used treatment modes include plasma exchange (PE), perfusion (PA), plasma dialysis filtration (PDF), and dual plasma molecular adsorption system (DPMAS).

[0003] Artificial liver therapy is highly operational, requiring the installation and priming of extracorporeal circulation tubing before treatment, which is labor-intensive. With the continuous updating of artificial liver blood purification treatment modes and technologies, the existing fixed modes and corresponding tubing are no longer fully applicable to the needs of clinical treatment development and the implementation of new treatment modes. Therefore, in clinical practice, multiple sets of tubing are sometimes used in combination to achieve complex treatments. However, assembling multiple sets of tubing has certain drawbacks and risks: First, it increases the workload and operational steps of the operator, and increases the risk of contamination; second, it increases the difficulty of nursing operations, making it difficult to achieve uniformity in clinical nursing quality, further increasing treatment risks and affecting treatment safety; third, the combination of multiple sets of tubing increases the patient's medical expenses. Therefore, designing a control method for blood purification tubing that can better adapt to the current clinical treatment needs and complex treatment modes can achieve automated changes in treatment modes. Summary of the Invention

[0004] This invention aims to at least solve one of the technical problems existing in the prior art. To this end, this invention provides a control method, device, medium, and program product for an artificial liver blood purification pipeline; the method of this invention controls the connection and disconnection between pipelines according to different types of treatment equipment, thereby controlling the flow direction of blood and plasma within the pipeline and achieving automated adaptation to multiple treatment modes.

[0005] The first aspect of this application discloses a method for controlling an artificial liver blood purification pipeline, the method comprising: The system obtains instructions to turn on or off at least one component in the pipeline; the pipeline includes: an input component, a secondary membrane separator, a second connecting pipe, a third connecting pipe, a filter pump P3, and an output component; the input component is connected to the lower end of the secondary membrane separator, the upper end of the secondary membrane separator is connected to the filter pump P3 through the second connecting pipe, the secondary membrane separator has a port one and a port two on its body, and port one is connected to the output component through the third connecting pipe; the component includes a disconnection interface one located at the second connecting pipe and a disconnection interface two located at the third connecting pipe; According to the instructions, the flow direction of the plasma flowing out after passing through the output component is changed; when the disconnection interface one and disconnection interface two are opened, the S1 interface located at disconnection interface one is connected to the S6 interface at disconnection interface two, controlling the plasma passing through the secondary membrane separator to flow into the output component; and the S2 interface located at disconnection interface one is connected to the S5 interface at disconnection interface two, controlling the plasma passing through the secondary membrane separator to flow out along port one and flow into port two through the filtration pump P3.

[0006] In some embodiments, the control of plasma flowing into the output component after passing through the secondary membrane separator includes: controlling plasma flowing into the output component sequentially from the upper end of the secondary membrane separator through the S1 interface and the S6 interface; Optionally, port one is located below port two.

[0007] In some embodiments, the pipeline further includes: a connecting pipe four disposed at port two, a T-shaped pipe one disposed at the connecting pipe four, a processing device, and a waste liquid pipe two disposed at the filtration pump P3, with a disconnection interface three disposed at the waste liquid pipe two; opening the disconnection interface one and disconnection interface two constitutes a first treatment mode, the first treatment mode further includes: obtaining an instruction to open the T-shaped pipe one, controlling the plasma passing through the secondary membrane separator to flow into the secondary membrane separator sequentially along port one through the S5 interface, the S2 interface, the filtration pump P3, the disconnection interface three, the processing device, the T-shaped pipe one, and port two; after flowing in along port two of the secondary membrane separator, it flows from top to bottom from the secondary membrane separator and flows out along port one on the side of the secondary membrane separator, the outflowing liquid flows into the filtration pump P3 through the S5 interface and the S2 interface, forming a self-circulation; Optionally, the processing device includes any of the following: a biological device, a non-biological adsorption device, or an irrigation device.

[0008] Optionally, the pipeline further includes a connecting pipe 1 located at the lower end of the input component and the lower end of the secondary membrane separator, and a waste liquid pipe 1 connected to the connecting pipe 1; the component further includes a T-shaped pipe 2 located at the connection between the connecting pipe 1 and the waste liquid pipe 1; when an instruction to close disconnect interface 1 and disconnect interface 2, and an instruction to close T-shaped pipe 1 and T-shaped pipe 2 are received, the second treatment mode is activated, and the plasma passing through the secondary membrane separator is controlled to be discharged sequentially from the upper end of the secondary membrane separator through the connecting pipe 2, the filtration pump P3, and the waste liquid pipe 2; at the same time, the plasma passing through the input component is also controlled to flow directly into the secondary membrane separator through the connecting pipe 1.

[0009] Optionally, the second treatment mode further includes controlling the plasma flowing out from port one into the output component through connecting tube three.

[0010] In some embodiments, the tubing further includes: a rehydration tank; the output component includes a plasma return pump P4, a venous reservoir, and a discharge venous tube; the input component includes: a primary membrane separator and a plasma reservoir; the lower end of the primary membrane separator is sequentially connected to the venous reservoir and the first end of the discharge venous tube via connecting pipes; the rehydration tank, plasma return pump P4, and venous reservoir are sequentially connected via connecting pipes; the lower end of the plasma reservoir is connected to the lower end of the secondary membrane separator via connecting pipe one, and the first port of the secondary membrane separator is sequentially connected to the venous reservoir via connecting pipe two, plasma return pump P4, and connecting pipe five; Optionally, the component also includes a multi-port tube disposed at the connecting tube three and a T-shaped tube three disposed at the connecting tube five; when an instruction to open disconnect interface one, multi-port tube, and T-shaped tube three is received, the third treatment mode is activated, and the plasma is controlled to flow sequentially through the S1 interface of the connecting tube two into the multi-port tube, T-shaped tube three, and then into the connecting tube five, thereby flowing into the venous pot.

[0011] Optionally, the multi-port pipe has at least five ports: the first port is used to connect to the S1 interface at the connecting pipe two; the second port is used to connect to port one of the secondary membrane separator; the third port is used to connect to T-tube three; the fourth port is used to connect to the replenishment tank; and the fifth port is used to connect to the return slurry pump P4.

[0012] In some embodiments, when an instruction to open T-tube two is received, the fourth treatment mode is activated, and the plasma after passing through the plasma pot is discharged as waste plasma through waste liquid tube one. Optionally, the fourth treatment mode further includes: obtaining a connecting tube between the infusion vessel, the plasma return pump P4, and the venous reservoir in the multi-port tubing, and controlling the nutrient solution in the infusion vessel to flow into the venous reservoir after passing through the plasma return pump P4; the rate at which the nutrient solution flows into the venous reservoir is consistent with the rate at which waste plasma is discharged; the nutrient solution is a replenishment / replacement solution, and the nutrient solution includes one or more of the following: plasma, albumin solution, colloid solution, plasma bag supplies, and balanced electrolyte solution.

[0013] In some embodiments, the component further includes a disconnection interface four disposed between the T-shaped tube three of the connecting tube five and the venous pot; when an instruction to open the disconnection interface four is received, interfaces S7 and S8 are formed on both sides of the disconnection interface four.

[0014] In some embodiments, the input component further includes: an inlet arterial tube, a blood pump P1, an arterial chamber, a primary membrane separator, and a plasma separation pump P2; the output component further includes an outlet venous tube; the first end of the inlet arterial tube is connected to the patient, and the second end of the inlet arterial tube is sequentially connected to the blood pump P1, the arterial chamber, and the upper end of the primary membrane separator via connecting tubes; the body side port two of the primary membrane separator is sequentially connected to the plasma separation pump P2 and the upper end of the plasma chamber via connecting tubes; the plasma return pump P4 is connected to the first end of the outlet venous tube, and the second end of the outlet venous tube is connected to the patient; In some embodiments, the first treatment mode is the treatment mode when using a novel secondary adsorption treatment device; Optionally, the second treatment mode is the treatment mode when using the DFPP treatment device; Optionally, the third treatment mode is the treatment mode when using the DPMAS treatment device; Optionally, the fourth treatment mode is the treatment mode when using a PE treatment device; In some embodiments, the disconnection interfaces at both ends of the disconnection interface are respectively provided with check valves or check clamps for connecting the disconnection interface to other pipelines.

[0015] A third aspect of this application discloses a computer device, the device comprising: a memory and a processor; the memory being used to store a computer program; and the processor executing the computer program to implement the steps of the above-described method.

[0016] The fourth aspect of this application discloses a computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the steps of the method described above.

[0017] The fifth aspect of this application discloses a computer program product, including a computer program that, when executed by a processor, implements the steps of the above-described method.

[0018] This application has the following beneficial effects: 1. This application innovatively discloses a control method for an artificial liver blood purification tubing system. This method automatically controls the connection and / or disconnection between tubing systems according to different treatment device types, thereby controlling the flow direction of blood and plasma within the tubing. This achieves automated adaptation to multiple treatment modes, overcoming the limitation of current tubing systems that can only perform a single corresponding treatment mode. The fully automated control method avoids the steps of assembling multiple sets of tubing, reducing the probability of errors and contamination during tubing installation, reducing medical costs, and reducing the workload of medical staff. It is worth noting that the four treatment modes in this application are parallel and do not interfere with each other.

[0019] 2. This application innovatively designs the tubing connecting the individual components in the extracorporeal circulation system in a separate manner, adds a detachable spiral interface to the separation joint, and sets a T-shaped tube at a certain point in the tubing to increase the direction of fluid flow. This solves the problem that each single treatment mode can only use its own unique set of tubing, which makes it impossible to replace some defective tubing and results in high costs.

[0020] 3. The control method and corresponding piping disclosed in this application also have the following advantages: 1) Reduced workflow: A single tubing system allows for seamless switching between multiple treatment modes, avoiding the current need to piece together two tubing systems for complex modes, and preventing the automatic pre-flushing program of the artificial liver blood purification machine from failing due to tubing assembly. First, this reduces consumable usage. Second, it eliminates human intervention in manual pre-flushing, reducing the possibility of contamination. Third, it lowers the difficulty of installation and pre-flushing operations, improving operability, facilitating rapid standardization, and enhancing treatment safety.

[0021] 2) Applicable to multiple modes: The improved tubing is not only applicable to various mature artificial liver treatment modes, but also to the development of new secondary adsorption / tubing / biological artificial liver treatment.

[0022] 3) Replaceable venous tubing and venous reservoir: Due to changes in the artificial liver blood purification treatment mode, the complexity has increased, and the treatment time has been prolonged, sometimes exceeding 8 hours. Therefore, the incidence of thrombosis in the extracorporeal circulation tubing, especially in the venous tubing, also increases with the duration of treatment. This manifests as increased instrument pressure during treatment, and even tubing clotting and blockage, leading to failure to achieve the expected treatment goals and unplanned discontinuation; consumption of clotting substances such as platelets, increasing the risk of bleeding during treatment; and economic losses. Therefore, designing replaceable venous tubing can avoid these situations.

[0023] The use of connectable disconnect ends in venous tubing breaks away from the conventional monolithic tubing design. This allows for the replacement of individual tubing components in the early stages of venous tubing thrombosis, avoiding the need to replace primary and secondary membranes, as well as the entire treatment tubing, due to venous tubing blockage. This approach reduces medical costs and patient expenses; minimizes adverse events such as blood loss and clotting factor depletion caused by tubing clotting; and reduces the workload and time costs associated with reinstalling and pre-flushing the tubing.

[0024] 4) Convenient Management: Patients with liver failure are critically ill and their conditions can change rapidly. Treating physicians will adjust treatment plans and modes as the condition progresses, and emergency treatment may be necessary in some cases. There are many types of non-biological artificial liver treatments, each requiring corresponding extracorporeal circulation tubing. This leads to a large inventory of various types of tubing, and also increases the risk of expired or incomplete tubing models and supply shortages. This not only increases the workload of management personnel but can also affect the timely treatment of patients. The improved tubing system allows for a single system to be used for multiple treatment modes, reducing management burden. Attached Figure Description

[0025] To more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0026] Figure 1 This is a schematic diagram of the method flow provided in the first aspect of the present invention; Figure 2 This is a schematic diagram of a control system for an artificial liver blood purification pipeline provided in the second aspect of the present invention; Figure 3 This is a schematic diagram of a computer device provided in an embodiment of the present invention; Figure 4 This is a schematic diagram of the architecture of an exemplary computing device provided in an embodiment of the present invention; Figure 5 This is a schematic diagram of the storage medium provided in an embodiment of the present invention; Figure 6 This is a schematic diagram of the tubing connection in the first treatment mode provided by an embodiment of the present invention; Figure 7 This is a schematic diagram of the tubing connection in the second treatment mode provided in the embodiment of the present invention; Figure 8 This is a schematic diagram of the tubing connection in the third treatment mode provided in the embodiment of the present invention; Figure 9 This is a schematic diagram of the tubing connection in the fourth treatment mode provided in the embodiment of the present invention; 1. Arterial reservoir; 2. Primary membrane separator; 3. Plasma reservoir; 31. Connecting tube 1; 32. Waste liquid tube 1; 33. T-tube 2; 4. Secondary membrane separator; 41. Connecting tube 2; 411. Disconnection port 1; 42. Connecting tube 3; 421. Disconnection port 2; 422. Multi-port tube; 43. Connecting tube 4; 431. T-tube 1; 44. Waste liquid tube 2; 441. Disconnection port 3; 45. Port 1; 46. Port 2; 5. Processing device; 6. Infusion reservoir; 7. Venous reservoir; 8. Connecting tube 5; 81. T-tube 3; 82. Disconnection port 4. Detailed Implementation

[0027] To enable those skilled in the art to better understand the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings.

[0028] In some of the processes described in the specification, claims, and accompanying drawings of this invention, multiple operations appearing in a specific order are included. However, it should be clearly understood that these operations may not be executed in the order they appear herein, or may be executed in parallel. The operation numbers, such as 101, 102, etc., are merely used to distinguish different operations and do not represent any execution order. Furthermore, these processes may include more or fewer operations, and these operations may be executed sequentially or in parallel. It should be noted that the descriptions such as "first," "second," etc., in this document are used to distinguish different messages, devices, modules, etc., and do not represent a sequential order, nor do they limit "first" and "second" to different types.

[0029] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0030] Figure 1 This is a schematic flowchart of a control method for an artificial liver blood purification pipeline provided in an embodiment of the present invention. Specifically, the method includes the following steps: 101: Obtain an instruction to turn on or off at least one component in the pipeline; the pipeline includes: an input component, a secondary membrane separator, a second connecting pipe, a third connecting pipe, a filter pump P3, and an output component; the input component is connected to the lower end of the secondary membrane separator, the upper end of the secondary membrane separator is connected to the filter pump P3 through the second connecting pipe, the secondary membrane separator has a port one and a port two on its body side, and port one is connected to the output component through the third connecting pipe; the component includes a disconnection interface one located at the second connecting pipe and a disconnection interface two located at the third connecting pipe; 102: Change the flow direction of the plasma after passing through the output component according to the instruction; when the disconnection interface one and disconnection interface two are opened, the S1 interface of disconnection interface one is connected to the S6 interface of disconnection interface two, controlling the plasma passing through the secondary membrane separator to flow into the output component; and the S2 interface of disconnection interface one is connected to the S5 interface of disconnection interface two, controlling the plasma passing through the secondary membrane separator to flow out along port one and flow into port two through the filtration pump P3; In some embodiments, the control of plasma flowing into the output component after passing through the secondary membrane separator includes: controlling plasma flowing into the output component sequentially from the upper end of the secondary membrane separator through the S1 interface and the S6 interface; Optionally, port one is located below port two.

[0031] In some embodiments, the pipeline further includes: a connecting pipe four disposed at port two, a T-shaped pipe one disposed at the connecting pipe four, a processing device, and a waste liquid pipe two disposed at the filtration pump P3, with a disconnection interface three disposed at the waste liquid pipe two; opening the disconnection interface one and disconnection interface two constitutes a first treatment mode, the first treatment mode further includes: obtaining an instruction to open the T-shaped pipe one, controlling the plasma passing through the secondary membrane separator to flow into the secondary membrane separator sequentially along port one through the S5 interface, the S2 interface, the filtration pump P3, the disconnection interface three, the processing device, the T-shaped pipe one, and port two; after flowing in along port two of the secondary membrane separator, it flows from top to bottom from the secondary membrane separator and flows out along port one on the side of the secondary membrane separator, the outflowing liquid flows into the filtration pump P3 through the S5 interface and the S2 interface, forming a self-circulation; Optionally, the processing device includes any of the following: a biological device, a non-biological adsorption device, or an irrigation device.

[0032] When undescribed components are involved, the undescribed components are assumed to be in their default, original state for that treatment mode. For example, when the first treatment mode is activated, the undescribed T-tube 2 controls the unobstructed flow of the connecting tube 1 between the plasma reservoir and the secondary membrane separator, preventing liquid in connecting tube 1 from flowing into waste tube 1; when there is no need to replace the intravenous reservoir and circuit separately, the disconnection port 4 of connecting tube 5 remains unobstructed; the infusion reservoir continuously replenishes liquid through the non-returning plasma pump via the connecting tube, etc., for details please refer to [link / reference]. Figure 6 As shown.

[0033] Specifically, such as Figure 6 As shown, the treatment device further includes: a flow stop clamp disposed at the first end of the inlet artery tube; a tubing connecting the infusion port and the pressure detection port is also disposed on the inlet artery tube, with flow stop clamps disposed on the two tubings respectively; a tubing connecting the anticoagulant pump and a tubing connecting the pressure detection port are sequentially disposed on the tubing connecting the blood pump and the arterial chamber, with flow stop clamps disposed on the two tubings respectively; and a T-tube is disposed at the connection between the tubing between the blood pump and the arterial chamber and the tubing connecting the anticoagulant pump. Two ports are provided on the side of the primary membrane separator. The lower port is connected to the plasma pump, and the upper port is connected to a pipeline with a stop clamp and a pressure detection port. A blood leakage detection structure is provided between the primary membrane separator and the plasma pump. A pipeline with a stop clamp and a pressure detection port is provided at the upper end of the plasma reservoir. The secondary membrane separator is a two-stage membrane separator. The pipeline connected to port one of the secondary membrane separator is sequentially set with a sampling / drug administration port and a stop clamp, and is detachably connected to connecting pipe four. The pipeline connected to port two of the secondary membrane separator is a T-tube. A pipeline is set through the T-tube to connect to the processing device. The connecting pipeline is sequentially set with a sampling / drug administration port and a stop clamp. A pressure detection port with a stop clamp is also set through the T-tube. Connecting pipe four is connected to the break of connecting pipe two. A stop clamp is set at the break of connecting pipe two. A stop clamp is set on the connecting pipeline between filtration pump P3 and the processing device, and the pipeline connected to waste liquid pipe two can be disconnected to prevent the liquid from the filtration pump from flowing to waste liquid pipe two and being discharged. Meanwhile, the other end of connecting pipe two at the upper end of the secondary membrane separator connects to connecting pipe three, and the other end of connecting pipe three connects to the return slurry pump P4; other locations on the pipeline include flow stop clamps, T-tubes, disconnections, and sampling / drug administration ports, as shown below. Figure 6 As shown.

[0034] In some embodiments, the pipeline further includes a connecting pipe 1 disposed at the lower end of the input component and the lower end of the secondary membrane separator, and a waste liquid pipe 1 communicating with the connecting pipe 1; the component further includes a T-shaped pipe 2 disposed at the connection between the connecting pipe 1 and the waste liquid pipe 1; when an instruction to close disconnection interface 1 and disconnection interface 2, and an instruction to close T-shaped pipe 1 and T-shaped pipe 2 are obtained, the second treatment mode is activated, and the plasma passing through the secondary membrane separator is controlled to be discharged sequentially from the upper end of the secondary membrane separator through the connecting pipe 2, the filtration pump P3, and the waste liquid pipe 2; at the same time, the plasma passing through the input component is also controlled to flow directly into the secondary membrane separator through the connecting pipe 1.

[0035] Optionally, the second treatment mode further includes controlling the plasma flowing out from port one into the output component through connecting tube three.

[0036] Optionally, the second treatment device further controls the flow of plasma exiting from the body-side port of the secondary membrane separator into the return plasma pump P4. Optionally, the second treatment device is a DFPP treatment device; specifically, as... Figure 7 As shown, port one at the lower end of the secondary membrane separator is directly connected to the return slurry pump P4, and port two at the lower end of the secondary membrane separator is connected to the pressure detection port.

[0037] When undescribed components are involved, the undescribed components are assumed to be in their default, original state for that treatment mode. For example, when the second treatment mode is activated, disconnection ports 1 and 2 (not described) remain unobstructed. Liquid output from the upper end of the secondary membrane separator flows into pump P3 through connecting pipe 2 and is then discharged through waste pipe 2. Liquid from port 1 of the secondary membrane separator flows into the return plasma pump P4 through connecting pipe 3, and liquid from port 2 of the secondary membrane separator is detected by the pressure detection port through connecting pipe 4. T-tube 2 (not described) controls the unobstructed flow of connecting pipe 1 between the plasma reservoir and the secondary membrane separator, preventing liquid from flowing into waste pipe 1. When there is no need to replace the intravenous reservoir and circuit separately, disconnection port 4 of connecting pipe 5 remains unobstructed. The infusion reservoir continuously replenishes liquid through the connecting pipe without the return plasma pump, etc., for details refer to [link to relevant documentation]. Figure 7 As shown.

[0038] In some embodiments, the tubing further includes: a rehydration tank; the output component includes a plasma return pump P4, a venous reservoir, and a discharge venous tube; the input component includes: a primary membrane separator and a plasma reservoir; the lower end of the primary membrane separator is sequentially connected to the venous reservoir and the first end of the discharge venous tube via connecting pipes; the rehydration tank, plasma return pump P4, and venous reservoir are sequentially connected via connecting pipes; the lower end of the plasma reservoir is connected to the lower end of the secondary membrane separator via connecting pipe one, and the first port of the secondary membrane separator is sequentially connected to the venous reservoir via connecting pipe two, plasma return pump P4, and connecting pipe five; Optionally, the component also includes a multi-port tube disposed at the connecting tube three and a T-shaped tube three disposed at the connecting tube five; when an instruction to open disconnect interface one, multi-port tube, and T-shaped tube three is received, the third treatment mode is activated, and the plasma is controlled to flow sequentially through the S1 interface of the connecting tube two into the multi-port tube, T-shaped tube three, and then into the connecting tube five, thereby flowing into the venous pot.

[0039] Optionally, the multi-port pipe has at least five ports: the first port is used to connect to the S1 interface at the connecting pipe two; the second port is used to connect to port one of the secondary membrane separator; the third port is used to connect to T-tube three; the fourth port is used to connect to the replenishment tank; and the fifth port is used to connect to the return slurry pump P4.

[0040] Optionally, the third treatment device is a DPMAS treatment device. Specifically, as shown in the image... Figure 8 As shown, the secondary membrane separator has no port design on its side; the plasma passing through the plasma reservoir flows directly out of the secondary membrane separator from bottom to top. The secondary membrane separator can be: a secondary membrane, perfusion unit, adsorber, filter, cell filter, etc.

[0041] When undescribed components are involved, the undescribed components are assumed to be in their default, original state for that treatment mode. For example, when the third treatment mode is activated, ports one and two on the body side of the secondary membrane separator are directly closed. Liquid only flows in from the lower end of the perfusion device and out from the upper end, flowing into connecting pipe five through disconnection port one. The S2 port, as well as the subsequent filter pump P3, waste liquid pipe two, processing device, etc., are directly closed; the refill pot and plasma return pump P4 are also directly closed; the undescribed T-tube two controls the unobstructed flow of connecting pipe one between the plasma pot and the secondary membrane separator, preventing liquid in connecting pipe one from flowing into waste liquid pipe one; when there is no need to replace the venous pot and circuit separately, disconnection port four of connecting pipe five remains unobstructed; the refill pot continuously replenishes liquid through the connecting pipe without the plasma return pump, etc., for details refer to Figure 8 As shown.

[0042] In some embodiments, when an instruction to open T-tube two is received, the fourth treatment mode is activated, and the plasma after passing through the plasma pot is discharged as waste plasma through waste liquid tube one. Optionally, the fourth treatment mode further includes: obtaining a connecting tube between the infusion vessel, the plasma return pump P4, and the venous reservoir in the multi-port tubing, and controlling the nutrient solution in the infusion vessel to flow into the venous reservoir after passing through the plasma return pump P4; the rate at which the nutrient solution flows into the venous reservoir is consistent with the rate at which waste plasma is discharged; the nutrient solution is a replenishment / replacement solution, and the nutrient solution includes one or more of the following: plasma, albumin solution, colloid solution, plasma bag supplies, and balanced electrolyte solution.

[0043] When undescribed components are involved, the undescribed components are assumed to be in their default, original state for that treatment mode. For example, when the fourth treatment mode is activated, plasma flows only sequentially from the bottom of the plasma reservoir through connecting tube one, T-tube two, and waste fluid tube one; other undescribed access lines and components are directly shut off. When there is no need to replace the intravenous reservoir and circuit separately, the disconnection port four of connecting tube five remains unobstructed. The infusion reservoir continuously replenishes fluid through the non-returning plasma pump via the connecting tube, etc. See details in the [link to relevant documentation]. Figure 9 As shown.

[0044] In some embodiments, the component further includes a disconnection interface four disposed between the T-shaped tube three of the connecting tube five and the venous pot; when an instruction to open the disconnection interface four is received, interfaces S7 and S8 are formed on both sides of the disconnection interface four.

[0045] In some embodiments, opening the disconnect interface means that the disconnect interface is disconnected, forming an interface with a disconnection end (2), and closing the disconnect interface means that the disconnect interface is connected, with no disconnection end interface.

[0046] In some embodiments, the input component further includes: an inlet arterial tube, a blood pump P1, an arterial chamber, a primary membrane separator, and a plasma separation pump P2; the output component further includes an outlet venous tube; the first end of the inlet arterial tube is connected to the patient, and the second end of the inlet arterial tube is sequentially connected to the blood pump P1, the arterial chamber, and the upper end of the primary membrane separator via connecting tubes; the body side port two of the primary membrane separator is sequentially connected to the plasma separation pump P2 and the upper end of the plasma chamber via connecting tubes; the plasma return pump P4 is connected to the first end of the outlet venous tube, and the second end of the outlet venous tube is connected to the patient; In some embodiments, the first treatment mode is the treatment mode when using a novel secondary adsorption treatment device; Optionally, the second treatment mode is the treatment mode when using the DFPP treatment device; Optionally, the third treatment mode is the treatment mode when using the DPMAS treatment device; Optionally, the fourth treatment mode is the treatment mode when using a PE treatment device; In some embodiments, the corresponding type of treatment device is activated according to the treatment mode required by the subject. As used herein, the terms "subject," "test subject," or "sample" refer to any animal (e.g., a mammal), including but not limited to humans, non-human primates, rodents, etc., which will become the recipient of a specific treatment. Generally, the terms "subject" and "patient" are used interchangeably herein when referring to human subjects. Preferably, the subject is a human.

[0047] In some embodiments, the disconnection interfaces at both ends of the disconnection interface are respectively provided with check valves or check clamps for connecting the disconnection interface to other pipelines.

[0048] exist Figure 6-9 In the middle, the flow stop clamp is shaped like the number 8, the pressure detection port is shaped like an equilateral pentagon, the T-type tube is represented by T, and the pipeline is equipped with a sampling / drug administration port, which is elliptical in shape. Specific implementation examples:

[0050] 1. Renovation (1) The secondary membrane inlet side of the extracorporeal circulation pipeline is designed as a separate pipeline, and a detachable spiral interface is added to both sides of the broken end.

[0051] (2) Add a T-shaped tube and a spiral interface to the upper end of the secondary membrane of the extracorporeal circulation tubing.

[0052] (3) A split design is added to the lower end side hole of the secondary membrane in the extracorporeal circulation pipeline, and a detachable spiral interface is added to both sides of the broken end.

[0053] (4) Add a cross-shaped connecting pipe design before the P4 pump to increase the liquid flow direction.

[0054] (5) The venous circuit catheter, the warmer and the venous pot are designed separately, and a detachable spiral interface is added to both sides of the cut end.

[0055] (6) The P4 pump is designed with a T-shaped tube and an extension tube, which can be connected to the cross-shaped structure.

[0056] (7) After the P3 pump, the waste liquid pipe is designed to be separate, and detachable spiral interfaces are added to both sides of the broken end.

[0057] (8) Add flow stop clamps on both sides of the added break end design.

[0058] 2. Technical Solution

[0059] 2.1 Structure, Connections, and Functions: (1) The secondary membrane inlet side pipeline is designed in a separate manner. D1 is the separation point, forming two disconnected ends, S1 and S2.

[0060] Connections: S1 and S6 are connected; S2 and S5 are connected. Function: Connecting S1 and S6 allows plasma from the secondary membrane to be drawn out from the outlet side of the secondary membrane and enter the vein via pump P4. Connecting S2 and S5 allows plasma from the secondary membrane to flow out from the lower end side hole towards pump P3.

[0061] (2) A T-shaped tube is added to the upper side hole of the secondary membrane to form two broken ends, S3 and S4.

[0062] Connection: The S4 end is connected to the M3 outlet side, at which point the S3 end is free; M3 is the processing device; Function: Substances passing through M3 enter the upper end of the secondary membrane side pore through the T-tube and enter the outer side of the secondary membrane.

[0063] (3) The lower end side hole of the secondary membrane is designed to be separated, with D3 as the separation point, forming two broken ends S5 and S6.

[0064] The connection and function are the same as (1).

[0065] (4) Add a T5 cross-shaped connecting pipe to the upper side of the P4 pump.

[0066] Connections: Can be connected to T6, can be connected to infusion fluid.

[0067] Function: Connects to T6 to form a plasma reinfusion bypass, allowing plasma to return to the vein (applicable during DPMAS therapy). Connects to fluid resuscitation to allow fluids to return to the vein via P4 pump.

[0068] (5) Using D4 as the separation point, two broken ends, S7 and S8, are formed.

[0069] Function: It can be connected to an independent intravenous line to allow for the individual replacement of the intravenous pot and circuit.

[0070] (6) The P4 pump is designed with a T-shaped pipe and an extension pipe, which can be connected to the T5 cross-shaped structure. The function is the same as (4).

[0071] (7) Using D2 as the separation point, two broken ends, S3 and S4, are formed.

[0072] Connection: S3 is connected to the M3 inlet side.

[0073] Function: S3 connects to the inlet side of M3, allowing plasma to be drawn from the lower end of the side port of M2 and then pumped into M3 via P3. M2 is a two-stage membrane separator; (8) T-tube structure: For example, the upper end T4 of the secondary membrane side hole features a T-shaped design, allowing one end to connect to a pressure sensor for detecting external membrane pressure. The other side opening is extended with a spiral opening design to allow connection to other non-biological perfusion / adsorption devices or bioreactor devices. For details, please refer to [reference needed]. Figure 6-9 This is a simplified diagram.

[0074] 2.3 Treatment Principle: 2.3.1 Function of each component (1) Primary membrane (plasma separator / filter): Its function is to separate a portion of plasma from whole blood.

[0075] (2) Secondary membrane (selective plasma component separator / secondary membrane separator / cell filter, etc.): Its function is to prevent particles / cells and other substances in non-biological perfusion / adsorption devices or bioreactor devices from falling into the blood circulation.

[0076] (3) Non-biological perfusion / adsorption devices / bioreactor devices: Their function is to adsorb toxins / detoxify / complete the exchange of substances, etc.

[0077] (4) Extracorporeal circulation tubing: used for artificial liver blood purification therapy to establish extracorporeal circulation.

[0078] 2.3.2 Principle (1) By disconnecting the pipeline and modifying the separation port, the upper and lower side holes of the secondary membrane are connected to the inlet and outlet of the non-biological perfusion / adsorption device / bioreactor device, thus completing the new artificial liver treatment.

[0079] (2) The addition of a detachable spiral interface allows for changes in the connection method of different interfaces within the pipeline. This alters the treatment principle and mode, thus enabling a single pipeline to meet the needs of multiple treatment modes.

[0080] (3) By using the disconnectable design between the heater and the venous pot, and adding a detachable spiral interface design, the problem of replacing the venous circuit separately can be solved.

[0081] (4) When disconnecting the design, add a check valve at the disconnection end of the pipeline. This can prevent liquid leakage and change the flow direction when disconnecting the pipeline.

[0082] Figure 3 This is a schematic diagram of a computer device provided in an embodiment of the present invention, such as... Figure 3 As shown, the device may include: one or more processors and one or more memories; wherein the memories store computer-readable code that, when run by the one or more processors, can perform the methods described above.

[0083] The processor in this embodiment can be an integrated circuit chip with signal processing capabilities. The processor can be a general-purpose processor, a digital signal processor (DSP), an application-specific integrated circuit (ASIC), an off-the-shelf programmable gate array (FPGA), or other programmable logic devices, discrete gate or transistor logic devices, or discrete hardware components. It can implement or execute the methods, operations, and logic block diagrams disclosed in this embodiment. The general-purpose processor can be a microprocessor or any conventional processor, and can be based on an x86 or ARM architecture.

[0084] In general, the various exemplary embodiments of this disclosure can be implemented in hardware or dedicated circuitry, software, firmware, logic, or any combination thereof. Some aspects can be implemented in hardware, while others can be implemented in firmware or software that can be executed by a controller, microprocessor, or other computing device. When aspects of embodiments of this disclosure are illustrated or described as block diagrams, flowcharts, or using some other graphical representation, it will be understood that the blocks, apparatuses, systems, techniques, or methods described herein can be implemented as non-limiting examples in hardware, software, firmware, dedicated circuitry or logic, general-purpose hardware or controllers or other computing devices, or some combination thereof.

[0085] For example, the method or apparatus according to embodiments of this disclosure can also be used by means of Figure 4 The architecture of the computing device 3000 shown is used for implementation. For example... Figure 4As shown, the computing device 3000 may include a bus 3010, one or more CPUs 3020, a read-only memory (ROM) 3030, a random access memory (RAM) 3040, a communication port 3050 connected to a network, an input / output component 3060, a hard disk 3070, etc. The storage devices in the computing device 3000, such as the ROM 3030 or the hard disk 3070, may store various data or files used for processing and / or communication of the methods provided in this disclosure, as well as program instructions executed by the CPU. The computing device 3000 may also include a user interface 3080. Of course, Figure 4 The architecture shown is merely exemplary and can be omitted as needed when implementing different devices. Figure 4 One or more components in the computing device shown.

[0086] This invention also includes a computer-readable storage medium, such as... Figure 5 The diagram illustrates a storage medium provided in an embodiment of the present invention. The computer storage medium 4020 stores computer-readable instructions 4010. When the computer-readable instructions 4010 are executed by a processor, the method described above according to embodiments of the present disclosure can be performed. The computer-readable storage medium in the embodiments of the present disclosure can be volatile memory or non-volatile memory, or may include both volatile and non-volatile memory. Non-volatile memory can be read-only memory (ROM), programmable read-only memory (PROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), or flash memory. Volatile memory can be random access memory (RAM), which is used as an external cache. By way of example, but not limitation, many forms of RAM are available, such as Static Random Access Memory (SRAM), Dynamic Random Access Memory (DRAM), Synchronous Dynamic Random Access Memory (SDRAM), Double Data Rate Synchronous Dynamic Random Access Memory (DDRSDRAM), Enhanced Synchronous Dynamic Random Access Memory (ESDRAM), Synchronous Link Dynamic Random Access Memory (SLDRAM), and Direct Memory Bus Random Access Memory (DR RAM). It should be noted that the memory used in the methods described herein is intended to include, but is not limited to, these and any other suitable types of memory.

[0087] This disclosure also provides a computer program product or system, including a computer program that, when executed by a processor, implements the steps of the above-described method.

[0088] In some embodiments, this embodiment also discloses a control system for an artificial liver blood purification pipeline, such as... Figure 2As shown, the system includes: The acquisition module 201 is used to acquire instructions to turn on or off at least one component in the pipeline; the pipeline includes: an input component, a secondary membrane separator, a second connecting pipe, a third connecting pipe, a filter pump P3, and an output component; the input component is connected to the lower end of the secondary membrane separator, the upper end of the secondary membrane separator is connected to the filter pump P3 through the second connecting pipe, the secondary membrane separator has a port one and a port two on its body side, and port one is connected to the output component through the third connecting pipe; the component includes a disconnection interface one located at the second connecting pipe and a disconnection interface two located at the third connecting pipe; The first processing module 202 is used to change the flow direction of the plasma after passing through the output component according to the instruction; when the disconnection interface one and disconnection interface two are opened, the S1 interface located at disconnection interface one is connected to the S6 interface of disconnection interface two, controlling the plasma passing through the secondary membrane separator to flow into the output component; and the S2 interface located at disconnection interface one is connected to the S5 interface of disconnection interface two, controlling the plasma passing through the secondary membrane separator to flow out along port one and flow into port two through the filtration pump P3.

[0089] In some embodiments, the system further includes: a second processing module, configured to acquire an instruction to open the T-tube one, and control the plasma passing through the secondary membrane separator to flow sequentially through port one, via interface S5, interface S2, filtration pump P3, disconnection interface three, processing device, T-tube one, and port two into the secondary membrane separator; after flowing in through port two of the secondary membrane separator, it flows from top to bottom from the secondary membrane separator and flows out through port one on the side of the secondary membrane separator; the liquid after flowing out flows through interface S5 and interface S2 into filtration pump P3, forming a self-circulation.

[0090] In some embodiments, the system further includes: a third processing module, configured to, upon receiving instructions to close disconnection interface one and disconnection interface two, and instructions to close T-tube one and T-tube two, activate a second treatment mode, controlling the plasma passing through the secondary membrane separator to be discharged sequentially from the upper end of the secondary membrane separator through connecting tube two, filtration pump P3, and waste liquid tube two; simultaneously, also controlling the plasma passing through the input component to flow directly into the secondary membrane separator through connecting tube one; optionally, the second treatment mode further includes: controlling the plasma flowing out from port one to flow into the output component through connecting tube three.

[0091] In some embodiments, the system further includes: a fourth processing module, used to activate a third treatment mode when an instruction is received to open disconnect interface one, multi-port tube, and T-tube three, and to control plasma to flow sequentially through the S1 interface of connecting tube two into the multi-port tube, T-tube three, and connecting tube five, thereby flowing into the venous pot.

[0092] In some embodiments, the system further includes: a fifth processing module, configured to activate a fourth treatment mode when an instruction to open the second T-tube is received, and control the plasma after passing through the plasma reservoir to be discharged as waste plasma through the first waste liquid tube; optionally, the fourth treatment mode further includes: acquiring the connecting pipe between the infusion reservoir, the reflux pump P4 and the venous reservoir in the multi-port tube, and controlling the nutrient solution in the infusion reservoir to flow into the venous reservoir after passing through the reflux pump P4; the rate at which the nutrient solution flows into the venous reservoir is consistent with the rate at which the waste plasma is discharged.

[0093] In some embodiments, the system further includes a sixth processing module, which, when an instruction to open disconnect interface four is obtained, forms an S7 interface and an S8 interface on both sides of disconnect interface four.

[0094] It should be noted that the flowcharts and block diagrams in the accompanying drawings illustrate the architecture, functionality, and operation of possible implementations of systems, methods, and computer program products according to various embodiments of this disclosure. In this regard, each block in a flowchart or block diagram may represent a module, segment, or portion of code containing one or more executable instructions for implementing a specified logical function. It should also be noted that in some alternative implementations, the functions indicated in the blocks may occur in a different order than those indicated in the drawings. For example, two consecutively indicated blocks may actually be executed substantially in parallel, and they may sometimes be executed in reverse order, depending on the functions involved. It should also be noted that each block in the block diagrams and / or flowcharts, and combinations of blocks in the block diagrams and / or flowcharts, can be implemented using a dedicated hardware-based system that performs the specified function or operation, or using a combination of dedicated hardware and computer instructions.

[0095] In general, the various exemplary embodiments of this disclosure can be implemented in hardware or dedicated circuitry, software, firmware, logic, or any combination thereof. Some aspects can be implemented in hardware, while others can be implemented in firmware or software that can be executed by a controller, microprocessor, or other computing device. When aspects of embodiments of this disclosure are illustrated or described as block diagrams, flowcharts, or using some other graphical representation, it will be understood that the blocks, apparatuses, systems, techniques, or methods described herein can be implemented as non-limiting examples in hardware, software, firmware, dedicated circuitry or logic, general-purpose hardware or controllers or other computing devices, or some combination thereof.

[0096] Those skilled in the art will clearly understand that, for the sake of convenience and brevity, the specific working processes of the systems, devices, and units described above can be referred to the corresponding processes in the foregoing method embodiments, and will not be repeated here.

[0097] In the several embodiments provided in this application, it should be understood that the disclosed systems, apparatuses, and methods can be implemented in other ways. For example, the apparatus embodiments described above are merely illustrative; for instance, the division of units is only a logical functional division, and in actual implementation, there may be other division methods. For example, multiple units or components may be combined or integrated into another system, or some features may be ignored or not executed. Furthermore, the coupling or direct coupling or communication connection shown or discussed may be an indirect coupling or communication connection between apparatuses or units through some interfaces, and may be electrical, mechanical, or other forms.

[0098] The units described as separate components may or may not be physically separate. The components shown as units may or may not be physical units; that is, they may be located in one place or distributed across multiple network units. Some or all of the units can be selected to achieve the purpose of this embodiment according to actual needs.

[0099] Furthermore, the functional units in the various embodiments of the present invention can be integrated into one processing unit, or each unit can exist physically separately, or two or more units can be integrated into one unit. The integrated unit can be implemented in hardware or as a software functional unit.

[0100] The exemplary embodiments of this disclosure described in detail above are merely illustrative and not restrictive. Those skilled in the art will understand that various modifications and combinations can be made to these embodiments or their features without departing from the principles and spirit of this disclosure, and such modifications should fall within the scope of this disclosure.

Claims

1. A computer device, characterized in that, The device includes: a memory and a processor; the memory is used to store a computer program; the processor executes the computer program to implement a control method for an artificial liver blood purification tubing, the method comprising the following steps: Obtain instructions to turn on or off at least one component in the pipeline; the pipeline includes: an input component, a secondary membrane separator, a second connecting pipe, a third connecting pipe, a filter pump P3, and an output component; the input component is connected to the lower end of the secondary membrane separator, the upper end of the secondary membrane separator is connected to the filter pump P3 through the second connecting pipe, the secondary membrane separator has a port 1 and a port 2 on its side, and port 1 is connected to the output component through the third connecting pipe; the component includes a disconnection interface 1 located at the second connecting pipe and a disconnection interface 2 located at the third connecting pipe, the disconnection interface 1 having an S1 interface and an S2 interface, and the disconnection interface 2 having an S5 interface and an S6 interface; The flow direction of the plasma after passing through the output component is changed according to the instructions; when disconnection interface one and disconnection interface two are opened, the first treatment mode is entered. The S1 interface of disconnection interface one is connected to the S6 interface of disconnection interface two, controlling the plasma after passing through the secondary membrane separator to flow out from its upper end, and sequentially flow into the output component through the S1 interface and the S6 interface; at the same time, the S2 interface of disconnection interface one is connected to the S5 interface of disconnection interface two, controlling the plasma after passing through the secondary membrane separator to flow out along port one on the body side, and sequentially flow into port two through the S5 interface, the S2 interface, and the filter pump P3, forming a self-circulating pathway; port one is located at the lower end of port two; The pipeline also includes a connecting pipe 1 located at the lower end of the input component and the lower end of the secondary membrane separator, and a waste liquid pipe 1 connected to the connecting pipe 1; the component also includes a T-shaped pipe 2 located at the connection between the connecting pipe 1 and the waste liquid pipe 1; when an instruction to close disconnect interface 1 and disconnect interface 2, and an instruction to close T-shaped pipe 1 and T-shaped pipe 2 are received, the second treatment mode is activated, and the plasma passing through the secondary membrane separator is controlled to be discharged sequentially from the upper end of the secondary membrane separator through the connecting pipe 2, the filtration pump P3, and the waste liquid pipe 2; wherein, the waste liquid pipe 2 is located at the filtration pump P3; at the same time, the plasma passing through the input component is also controlled to flow directly into the secondary membrane separator through the connecting pipe 1; The component also includes a multi-port tube disposed at the connecting tube three and a T-shaped tube three disposed at the connecting tube five; when an instruction to open disconnect interface one, multi-port tube, and T-shaped tube three is received, the third treatment mode is activated, and the plasma is controlled to flow sequentially through the S1 interface of the connecting tube two into the multi-port tube, T-shaped tube three, and then into the connecting tube five, thereby flowing into the venous pot. The connecting tube five is a conduit connecting the venous pot and the multi-port tube. When the command to open T-tube two is received, the fourth treatment mode is activated, and the plasma after passing through the plasma pot is discharged as waste plasma through waste liquid tube one. Different treatment modes correspond to different types of treatment equipment. The first treatment mode is the treatment mode when using a novel secondary adsorption treatment device. The second treatment mode is the treatment mode when using a dual plasma exchange DFPP treatment device. The third treatment mode is the treatment mode when using a dual plasma molecular adsorption system DPMAS treatment device. The fourth treatment mode is the treatment mode when using a plasma exchange PE treatment device.

2. The computer device according to claim 1, characterized in that, The pipeline further includes: a connecting pipe four disposed at port two, a T-shaped pipe one disposed at the connecting pipe four, and a processing device, and a disconnection interface three disposed at waste liquid pipe two; opening the disconnection interface one and disconnection interface two constitutes a first treatment mode, the first treatment mode further includes: obtaining an instruction to open the T-shaped pipe one, controlling the plasma passing through the secondary membrane separator to flow into the secondary membrane separator sequentially along port one through interface S5, interface S2, filtration pump P3, disconnection interface three, processing device, T-shaped pipe one, and port two; after flowing in along port two of the secondary membrane separator, it flows from top to bottom from the secondary membrane separator and flows out along port one on the side of the secondary membrane separator, and the outflowing liquid flows into filtration pump P3 through interface S5 and interface S2, forming a self-circulation.

3. The computer device according to claim 2, characterized in that, The processing device includes any one of the following: biological device, non-biological adsorption device, or irrigation device.

4. The computer device according to claim 1, characterized in that, The second treatment mode also includes controlling the plasma flowing out from port one into the output component through connecting tube three.

5. The computer device according to claim 4, characterized in that, The pipeline also includes: a rehydration tank; the output component includes a plasma return pump P4, a venous reservoir, and a discharge venous tube; the input component includes: a primary membrane separator and a plasma reservoir; the lower end of the primary membrane separator is sequentially connected to the venous reservoir and the first end of the discharge venous tube via connecting pipe five; the rehydration tank, plasma return pump P4, and venous reservoir are sequentially connected via connecting pipe five; the lower end of the plasma reservoir is connected to the lower end of the secondary membrane separator via connecting pipe one, and the first port of the secondary membrane separator is sequentially connected to the venous reservoir via connecting pipe two, plasma return pump P4, and connecting pipe five.

6. The computer device according to claim 1, characterized in that, The multi-port pipe has at least five ports: the first port is used to connect to the S1 interface at the second connecting pipe; the second port is used to connect to port one of the secondary membrane separator; the third port is used to connect to the third T-tube; the fourth port is used to connect to the replenishment tank; and the fifth port is used to connect to the return slurry pump.

7. The computer device according to claim 1, characterized in that, The fourth treatment mode further includes: obtaining a connecting tube between the infusion vessel, the plasma return pump P4, and the venous reservoir in the multi-port tubing, and controlling the nutrient solution in the infusion vessel to flow into the venous reservoir after passing through the plasma return pump P4; the rate at which the nutrient solution flows into the venous reservoir is consistent with the rate at which waste plasma is discharged; the nutrient solution is a replenishment / replacement solution, and the nutrient solution includes one or more of the following: plasma, albumin solution, colloid solution, plasma bag supplies, and balanced electrolyte solution.

8. The computer device according to claim 7, characterized in that, The component also includes a disconnection interface four disposed between the T-shaped tube three of the connecting tube five and the venous pot; when an instruction to open the disconnection interface four is received, interfaces S7 and S8 are formed on both sides of the disconnection interface four.

9. The computer device according to claim 1, characterized in that, The input components also include: an inlet arterial tube, a blood pump P1, an arterial chamber, a primary membrane separator, and a plasma separation pump P2; the output components also include an outlet venous tube; the first end of the inlet arterial tube is connected to the patient, and the second end of the inlet arterial tube is sequentially connected to the blood pump P1, the arterial chamber, and the upper end of the primary membrane separator via connecting tubes; the second port of the primary membrane separator is sequentially connected to the plasma separation pump P2 and the upper end of the plasma chamber via connecting tubes; the return plasma pump P4 is connected to the first end of the outlet venous tube, and the second end of the outlet venous tube is connected to the patient.

10. The computer device according to claim 1, characterized in that, The disconnection interface is equipped with a flow stop valve or a flow stop clamp at each of the two disconnection interfaces.

11. A computer-readable storage medium, characterized in that, It stores a computer program, which, when executed by a processor, implements the steps of a control method for an artificial liver blood purification tubing. The steps of the method include: Obtain instructions to turn on or off at least one component in the pipeline; the pipeline includes: an input component, a secondary membrane separator, a second connecting pipe, a third connecting pipe, a filter pump P3, and an output component; the input component is connected to the lower end of the secondary membrane separator, the upper end of the secondary membrane separator is connected to the filter pump P3 through the second connecting pipe, the secondary membrane separator has a port 1 and a port 2 on its side, and port 1 is connected to the output component through the third connecting pipe; the component includes a disconnection interface 1 located at the second connecting pipe and a disconnection interface 2 located at the third connecting pipe, the disconnection interface 1 having an S1 interface and an S2 interface, and the disconnection interface 2 having an S5 interface and an S6 interface; The flow direction of the plasma after passing through the output component is changed according to the instructions; when disconnection interface one and disconnection interface two are opened, the first treatment mode is entered. The S1 interface of disconnection interface one is connected to the S6 interface of disconnection interface two, controlling the plasma after passing through the secondary membrane separator to flow out from its upper end, and sequentially flow into the output component through the S1 interface and the S6 interface; at the same time, the S2 interface of disconnection interface one is connected to the S5 interface of disconnection interface two, controlling the plasma after passing through the secondary membrane separator to flow out along port one on the body side, and sequentially flow into port two through the S5 interface, the S2 interface, and the filter pump P3, forming a self-circulating pathway; port one is located at the lower end of port two; The pipeline also includes a connecting pipe 1 located at the lower end of the input component and the lower end of the secondary membrane separator, and a waste liquid pipe 1 connected to the connecting pipe 1; the component also includes a T-shaped pipe 2 located at the connection between the connecting pipe 1 and the waste liquid pipe 1; when an instruction to close disconnect interface 1 and disconnect interface 2, and an instruction to close T-shaped pipe 1 and T-shaped pipe 2 are received, the second treatment mode is activated, and the plasma passing through the secondary membrane separator is controlled to be discharged sequentially from the upper end of the secondary membrane separator through the connecting pipe 2, the filtration pump P3, and the waste liquid pipe 2; wherein, the waste liquid pipe 2 is located at the filtration pump P3; at the same time, the plasma passing through the input component is also controlled to flow directly into the secondary membrane separator through the connecting pipe 1; The component also includes a multi-port tube disposed at the connecting tube three and a T-shaped tube three disposed at the connecting tube five; when an instruction to open disconnect interface one, multi-port tube, and T-shaped tube three is received, the third treatment mode is activated, and the plasma is controlled to flow sequentially through the S1 interface of the connecting tube two into the multi-port tube, T-shaped tube three, and then into the connecting tube five, thereby flowing into the venous pot. The connecting tube five is a conduit connecting the venous pot and the multi-port tube. When the command to open T-tube two is received, the fourth treatment mode is activated, and the plasma after passing through the plasma pot is discharged as waste plasma through waste liquid tube one. Different treatment modes correspond to different types of treatment equipment. The first treatment mode is the treatment mode when using a novel secondary adsorption treatment device. The second treatment mode is the treatment mode when using a dual plasma exchange DFPP treatment device. The third treatment mode is the treatment mode when using a dual plasma molecular adsorption system DPMAS treatment device. The fourth treatment mode is the treatment mode when using a plasma exchange PE treatment device.

12. The computer-readable storage medium according to claim 11, characterized in that, The pipeline further includes: a connecting pipe four disposed at port two, a T-shaped pipe one disposed at the connecting pipe four, and a processing device, and a disconnection interface three disposed at waste liquid pipe two; opening the disconnection interface one and disconnection interface two constitutes a first treatment mode, the first treatment mode further includes: obtaining an instruction to open the T-shaped pipe one, controlling the plasma passing through the secondary membrane separator to flow into the secondary membrane separator sequentially along port one through interface S5, interface S2, filtration pump P3, disconnection interface three, processing device, T-shaped pipe one, and port two; after flowing in along port two of the secondary membrane separator, it flows from top to bottom from the secondary membrane separator and flows out along port one on the side of the secondary membrane separator, and the outflowing liquid flows into filtration pump P3 through interface S5 and interface S2, forming a self-circulation.

13. The computer-readable storage medium according to claim 12, characterized in that, The processing device includes any one of the following: biological device, non-biological adsorption device, or irrigation device.

14. The computer-readable storage medium according to claim 11, characterized in that, The second treatment mode also includes controlling the plasma flowing out from port one into the output component through connecting tube three.

15. The computer-readable storage medium according to claim 14, characterized in that, The pipeline also includes: a rehydration tank; the output component includes a plasma return pump P4, a venous reservoir, and a discharge venous tube; the input component includes: a primary membrane separator and a plasma reservoir; the lower end of the primary membrane separator is sequentially connected to the venous reservoir and the first end of the discharge venous tube via connecting pipe five; the rehydration tank, plasma return pump P4, and venous reservoir are sequentially connected via connecting pipe five; the lower end of the plasma reservoir is connected to the lower end of the secondary membrane separator via connecting pipe one, and the first port of the secondary membrane separator is sequentially connected to the venous reservoir via connecting pipe two, plasma return pump P4, and connecting pipe five.

16. The computer-readable storage medium according to claim 11, characterized in that, The multi-port pipe has at least five ports: the first port is used to connect to the S1 interface at the second connecting pipe; the second port is used to connect to port one of the secondary membrane separator; the third port is used to connect to the third T-tube; the fourth port is used to connect to the replenishment tank; and the fifth port is used to connect to the return slurry pump.

17. The computer-readable storage medium according to claim 11, characterized in that, The fourth treatment mode further includes: obtaining a connecting tube between the infusion vessel, the plasma return pump P4, and the venous reservoir in the multi-port tubing, and controlling the nutrient solution in the infusion vessel to flow into the venous reservoir after passing through the plasma return pump P4; the rate at which the nutrient solution flows into the venous reservoir is consistent with the rate at which waste plasma is discharged; the nutrient solution is a replenishment / replacement solution, and the nutrient solution includes one or more of the following: plasma, albumin solution, colloid solution, plasma bag supplies, and balanced electrolyte solution.

18. The computer-readable storage medium according to claim 17, characterized in that, The component also includes a disconnection interface four disposed between the T-shaped tube three of the connecting tube five and the venous pot; when an instruction to open the disconnection interface four is received, interfaces S7 and S8 are formed on both sides of the disconnection interface four.

19. The computer-readable storage medium according to claim 11, characterized in that, The input components also include: an inlet arterial tube, a blood pump P1, an arterial chamber, a primary membrane separator, and a plasma separation pump P2; the output components also include an outlet venous tube; the first end of the inlet arterial tube is connected to the patient, and the second end of the inlet arterial tube is sequentially connected to the blood pump P1, the arterial chamber, and the upper end of the primary membrane separator via connecting tubes; the second port of the primary membrane separator is sequentially connected to the plasma separation pump P2 and the upper end of the plasma chamber via connecting tubes; the return plasma pump P4 is connected to the first end of the outlet venous tube, and the second end of the outlet venous tube is connected to the patient.

20. The computer-readable storage medium according to claim 11, characterized in that, The disconnection interface is equipped with a flow stop valve or a flow stop clamp at each of the two disconnection interfaces.

21. A computer program product, comprising a computer program, characterized in that, When executed by a processor, the computer program implements the steps of a control method for an artificial liver blood purification tubing, the steps of which include: Obtain instructions to turn on or off at least one component in the pipeline; the pipeline includes: an input component, a secondary membrane separator, a second connecting pipe, a third connecting pipe, a filter pump P3, and an output component; the input component is connected to the lower end of the secondary membrane separator, the upper end of the secondary membrane separator is connected to the filter pump P3 through the second connecting pipe, the secondary membrane separator has a port 1 and a port 2 on its side, and port 1 is connected to the output component through the third connecting pipe; the component includes a disconnection interface 1 located at the second connecting pipe and a disconnection interface 2 located at the third connecting pipe, the disconnection interface 1 having an S1 interface and an S2 interface, and the disconnection interface 2 having an S5 interface and an S6 interface; The flow direction of the plasma after passing through the output component is changed according to the instructions; when disconnection interface one and disconnection interface two are opened, the first treatment mode is entered. The S1 interface of disconnection interface one is connected to the S6 interface of disconnection interface two, controlling the plasma after passing through the secondary membrane separator to flow out from its upper end, and sequentially flow into the output component through the S1 interface and the S6 interface; at the same time, the S2 interface of disconnection interface one is connected to the S5 interface of disconnection interface two, controlling the plasma after passing through the secondary membrane separator to flow out along port one on the body side, and sequentially flow into port two through the S5 interface, the S2 interface, and the filter pump P3, forming a self-circulating pathway; port one is located at the lower end of port two; The pipeline also includes a connecting pipe 1 located at the lower end of the input component and the lower end of the secondary membrane separator, and a waste liquid pipe 1 connected to the connecting pipe 1; the component also includes a T-shaped pipe 2 located at the connection between the connecting pipe 1 and the waste liquid pipe 1; when an instruction to close disconnect interface 1 and disconnect interface 2, and an instruction to close T-shaped pipe 1 and T-shaped pipe 2 are received, the second treatment mode is activated, and the plasma passing through the secondary membrane separator is controlled to be discharged sequentially from the upper end of the secondary membrane separator through the connecting pipe 2, the filtration pump P3, and the waste liquid pipe 2; wherein, the waste liquid pipe 2 is located at the filtration pump P3; at the same time, the plasma passing through the input component is also controlled to flow directly into the secondary membrane separator through the connecting pipe 1; The component also includes a multi-port tube disposed at the connecting tube three and a T-shaped tube three disposed at the connecting tube five; when an instruction to open disconnect interface one, multi-port tube, and T-shaped tube three is received, the third treatment mode is activated, and the plasma is controlled to flow sequentially through the S1 interface of the connecting tube two into the multi-port tube, T-shaped tube three, and then into the connecting tube five, thereby flowing into the venous pot. The connecting tube five is a conduit connecting the venous pot and the multi-port tube. When the command to open T-tube two is received, the fourth treatment mode is activated, and the plasma after passing through the plasma pot is discharged as waste plasma through waste liquid tube one. Different treatment modes correspond to different types of treatment equipment. The first treatment mode is the treatment mode when using a novel secondary adsorption treatment device. The second treatment mode is the treatment mode when using a dual plasma exchange DFPP treatment device. The third treatment mode is the treatment mode when using a dual plasma molecular adsorption system DPMAS treatment device. The fourth treatment mode is the treatment mode when using a plasma exchange PE treatment device.

22. The computer program product according to claim 21, characterized in that, The pipeline further includes: a connecting pipe four disposed at port two, a T-shaped pipe one disposed at the connecting pipe four, and a processing device, and a disconnection interface three disposed at waste liquid pipe two; opening the disconnection interface one and disconnection interface two constitutes a first treatment mode, the first treatment mode further includes: obtaining an instruction to open the T-shaped pipe one, controlling the plasma passing through the secondary membrane separator to flow into the secondary membrane separator sequentially along port one through interface S5, interface S2, filtration pump P3, disconnection interface three, processing device, T-shaped pipe one, and port two; after flowing in along port two of the secondary membrane separator, it flows from top to bottom from the secondary membrane separator and flows out along port one on the side of the secondary membrane separator, and the outflowing liquid flows into filtration pump P3 through interface S5 and interface S2, forming a self-circulation.

23. The computer program product according to claim 22, characterized in that, The processing device includes any one of the following: biological device, non-biological adsorption device, or irrigation device.

24. The computer program product according to claim 21, characterized in that, The second treatment mode also includes controlling the plasma flowing out from port one into the output component through connecting tube three.

25. The computer program product according to claim 24, characterized in that, The pipeline also includes: a rehydration tank; the output component includes a plasma return pump P4, a venous reservoir, and a discharge venous tube; the input component includes: a primary membrane separator and a plasma reservoir; the lower end of the primary membrane separator is sequentially connected to the venous reservoir and the first end of the discharge venous tube via connecting pipe five; the rehydration tank, plasma return pump P4, and venous reservoir are sequentially connected via connecting pipe five; the lower end of the plasma reservoir is connected to the lower end of the secondary membrane separator via connecting pipe one, and the first port of the secondary membrane separator is sequentially connected to the venous reservoir via connecting pipe two, plasma return pump P4, and connecting pipe five.

26. The computer program product according to claim 21, characterized in that, The multi-port pipe has at least five ports: the first port is used to connect to the S1 interface at the second connecting pipe; the second port is used to connect to port one of the secondary membrane separator; the third port is used to connect to the third T-tube; the fourth port is used to connect to the replenishment tank; and the fifth port is used to connect to the return slurry pump.

27. The computer program product according to claim 21, characterized in that, The fourth treatment mode further includes: obtaining a connecting tube between the infusion vessel, the plasma return pump P4, and the venous reservoir in the multi-port tubing, and controlling the nutrient solution in the infusion vessel to flow into the venous reservoir after passing through the plasma return pump P4; the rate at which the nutrient solution flows into the venous reservoir is consistent with the rate at which waste plasma is discharged; the nutrient solution is a replenishment / replacement solution, and the nutrient solution includes one or more of the following: plasma, albumin solution, colloid solution, plasma bag supplies, and balanced electrolyte solution.

28. The computer program product according to claim 27, characterized in that, The component also includes a disconnection interface four disposed between the T-shaped tube three of the connecting tube five and the venous pot; when an instruction to open the disconnection interface four is received, interfaces S7 and S8 are formed on both sides of the disconnection interface four.

29. The computer program product according to claim 21, characterized in that, The input components also include: an inlet arterial tube, a blood pump P1, an arterial chamber, a primary membrane separator, and a plasma separation pump P2; the output components also include an outlet venous tube; the first end of the inlet arterial tube is connected to the patient, and the second end of the inlet arterial tube is sequentially connected to the blood pump P1, the arterial chamber, and the upper end of the primary membrane separator via connecting tubes; the second port of the primary membrane separator is sequentially connected to the plasma separation pump P2 and the upper end of the plasma chamber via connecting tubes; the return plasma pump P4 is connected to the first end of the outlet venous tube, and the second end of the outlet venous tube is connected to the patient.

30. The computer program product according to claim 21, characterized in that, The disconnection interface is equipped with a flow stop valve or a flow stop clamp at each of the two disconnection interfaces.

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