Traditional Chinese medicine composition for treating skin itch as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition for treating skin itch as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The invention provides a traditional Chinese medicine composition which is prepared from the following raw materials in parts by mass: cortex phellodendri, radix scutellariae, radix angelicae sinensis, radix sophorae flavescentis, rhizoma atractylodis, rhizoma alismatis, radix et rhizoma rhei, radix saposhnikoviae, rhizoma corydalis, semen arecae, fructus cnidii, cortex dictamni and fructus kochiae. The traditional Chinese medicine composition jointly exerts the effect of treating skin itch under the combined action of all the medicines, and is suitable for itching symptoms caused by various skin diseases, such as systemic itching, anal itching, skin disease itching, nervous itching, psychiatric itching, multi-factor itching and unexplained itching. Results of embodiments of the invention show that the traditional Chinese medicine composition has a good curative effect in traditional Chinese medicine external treatment of patients with skin itch.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating skin itching, and a preparation method and application thereof. Background Art

[0002] Pruritus is a common disease and a common comorbid symptom of many diseases with a high incidence. Patients often become irritable, restless, and suffer from insomnia, which seriously affects their quality of life. Clinically, it can be divided into six types: systemic pruritus, dermatological pruritus, neurogenic pruritus, psychogenic pruritus, multifactorial pruritus, and unexplained pruritus.

[0003] Most of the western medicines used to treat pruritus are symptomatic treatments, which only treat the symptoms but not the root cause, and the treatment effect is limited. Currently, the western medicines commonly used for pruritus include antihistamines such as sodium thiosulfate, loratadine, cetirizine, ebastine, and hormonal drugs such as flumethasone, calcipotriol ointment, and fluticasone propionate cream. While they have certain therapeutic effects, they also have complications from the use of hormonal drugs and are not suitable for long-term use.

[0004] Many studies have shown that Chinese medicine has more advantages than Western medicine in treating pruritus, and the market for Chinese medicine preparations for treating pruritus is huge. However, the significant advantages of Chinese medicine in the treatment of pruritus have not been reflected, and the effects of Chinese medicine in the treatment of pruritus reported so far are often limited. Summary of the invention

[0005] In view of the defects in the prior art, the object of the present invention is to provide a Chinese medicine composition for treating skin itching, which can effectively relieve the symptoms of skin itching.

[0006] The objective of the present invention is achieved through the following technical solutions:

[0007] The present invention provides a Chinese medicine composition, wherein the raw materials used for preparation include, by weight:

[0008] 1.5-2 parts of Phellodendron chinense, 0.5-1 part of Scutellaria baicalensis, 0.5-1 part of Angelica sinensis, 1.5-2 parts of Sophora flavescens, 0.5-1 part of Atractylodes lancea, 0.5-1 part of Alisma orientalis, 0.6-0.9 part of Rhubarb, 0.5-1 part of Saposhnikovia divaricata, 0.5-1 part of Corydalis yanhusuo, 0.5-1 part of Areca catechu, 0.5-1 part of Cnidium monnieri, 0.5-1 part of Dictamni cortex and 0.5-1 part of Kochia scoparia.

[0009] Preferably, the raw materials for preparation include, by weight:

[0010] 1.8-2 parts of Phellodendron chinense, 0.8-1 part of Scutellaria baicalensis, 0.8-1 part of Angelica sinensis, 1.8-2 parts of Sophora flavescens, 0.8-1 part of Atractylodes lancea, 0.8-1 part of Alisma orientalis, 0.7-0.9 part of Rhubarb, 0.8-1 part of Saposhnikovia divaricata, 0.8-1 part of Corydalis yanhusuo, 0.8-1 part of Areca catechu, 0.8-1 part of Cnidium monnieri, 0.8-1 part of Dictamni cortex and 0.8-1 part of Kochia scoparia.

[0011] Preferably, the raw materials for preparation include, by weight:

[0012] 2 parts of Phellodendron chinense, 1 part of Scutellaria baicalensis, 1 part of Angelica sinensis, 2 parts of Sophora flavescens, 1 part of Atractylodes macrocephala, 1 part of Alisma orientalis, 0.9 part of Rhubarb, 1 part of Saposhnikovia divaricata, 1 part of Corydalis yanhusuo, 1 part of Areca catechu, 1 part of Cnidium monnieri, 1 part of Dictamni cortex and 1 part of Kochia scoparia.

[0013] The present invention provides a method for preparing the Chinese medicine composition described in the above technical solution, comprising the following steps:

[0014] The raw materials are mixed with water and soaked, and then first decocted to obtain a first decocted medicinal liquid and medicinal residues;

[0015] The obtained medicinal residue is mixed with water for a second decoction to obtain a second decoction medicinal liquid;

[0016] The first decoction liquid and the second decoction liquid are mixed to obtain a Chinese medicine composition.

[0017] Preferably, the first decoction time is 30 minutes; the second decoction time is 15 to 25 minutes.

[0018] Preferably, a low heat is used to maintain a slight boil during the first decoction and the second decoction.

[0019] Preferably, when the raw materials are mixed with water or the obtained medicinal residues are mixed with water, the amount of water added is such that the water covers the medicinal surface by 1 to 3 cm.

[0020] The present invention provides the use of the Chinese medicine composition described in the above technical solution or the Chinese medicine composition prepared by the preparation method described in the above technical solution in preparing a medicine for treating skin itching.

[0021] Preferably, the pruritus includes any one or two or more of systemic pruritus, anal pruritus, dermatological pruritus, neuropathic pruritus, psychogenic pruritus, multifactorial pruritus and unexplained pruritus.

[0022] Preferably, the medicine includes an external preparation; the external preparation includes any one or more of a decoction, a fumigation preparation, a powder and a granule.

[0023] Beneficial effects of the present invention:

[0024] The invention provides a Chinese medicine composition, wherein the raw materials for preparation include, by weight, 1.5-2 parts of Phellodendron, 0.5-1 part of Scutellaria, 0.5-1 part of Angelica, 1.5-2 parts of Sophora flavescens, 0.5-1 part of Atractylodes, 0.5-1 part of Orientalis, 0.6-0.9 part of Radix Rhizoma Rhei, 0.5-1 part of Saposhnikovia divaricata, 0.5-1 part of Corydalis yanhusuo, 0.5-1 part of Areca catechu, 0.5-1 part of Cnidium monnieri, 0.5-1 part of Dictamni cortex and 0.5-1 part of Kochia scoparia. According to the theories of traditional Chinese medicine for syndrome differentiation and treatment such as "blood deficiency generates wind, wind prevails and carries dampness", "weak body suffers from wind, wind enters the skin, qi and blood fight against each other", the invention creatively prepares the Chinese medicine composition for treating skin pruritus by combining Sophora flavescens, Phellodendron chinense and Scutellaria baicalensis with the effects of clearing heat and drying dampness, Dictamni cortex, Saposhnikovia divaricata, Cnidium monnieri and other medicinal materials with the effects of dispelling wind and detoxifying. In the prescription, Sophora flavescens, Phellodendron amurense and Scutellaria baicalensis are the monarchs, Dictamni cortex, Saposhnikovia divaricata and Cnidium monnieri are the ministers, and Angelica sinensis, Atractylodes lancea, Orientalis rhizome, Rhubarb, Corydalis yanhusuo, Areca nut and Kochia scoparia are the assistants. Sophora flavescens, Phellodendron amurense and Scutellaria baicalensis clear away heat and dampness, detoxify and kill insects; Dictamni cortex clears heat and dampness, dispels wind and detoxifies, Saposhnikovia divaricata dries dampness, dispels wind and relieves exterior symptoms, Cnidium monnieri kills insects and relieves itching, dries dampness and dispels wind, and assists Sophora flavescens, Phellodendron amurense and Scutellaria baicalensis in drying dampness, clearing heat and relieving itching; Atractylodes lancea strengthens the effect of Dictamni cortex and Saposhnikovia divaricata in dispelling wind and serves as the assistant; Orientalis rhizome promotes diuresis and eliminates dampness, Rhubarb clears heat and purges fire, cools blood and detoxifies, Angelica sinensis and Corydalis yanhusuo promote blood circulation and relieve pain, Areca nut promotes qi and diuresis, Kochia scoparia clears heat and dampness and relieves itching, and strengthens the monarch's function of clearing heat and relieving itching, serving as the assistants. The Chinese medicine composition provided by the present invention plays a role in treating skin itching under the combined action of various drugs. The Chinese medicine composition is suitable for treating itching symptoms caused by various skin diseases, such as systemic itching, skin disease itching, neurogenic itching, psychogenic itching, multi-factor itching and unexplained itching. The results of the examples of the present invention show that the Chinese medicine composition provided by the present invention has achieved good therapeutic effects in the external treatment of skin itching patients with traditional Chinese medicine. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0026] Figure 1 The present invention is a flow chart of a method for preparing a decoction of a Chinese medicine composition;

[0027] Figure 2 This is a picture of the finished product of the Chinese medicine composition decoction;

[0028] Figure 3 This is the picture of the case 2 before treatment;

[0029] Figure 4 This is a picture of the situation of Application Example 2 one week after treatment. DETAILED DESCRIPTION

[0030] The present invention provides a Chinese medicine composition, wherein the raw materials used for preparation include, by weight:

[0031] 1.5-2 parts of Phellodendron chinense, 0.5-1 part of Scutellaria baicalensis, 0.5-1 part of Angelica sinensis, 1.5-2 parts of Sophora flavescens, 0.5-1 part of Atractylodes lancea, 0.5-1 part of Alisma orientalis, 0.6-0.9 part of Rhubarb, 0.5-1 part of Saposhnikovia divaricata, 0.5-1 part of Corydalis yanhusuo, 0.5-1 part of Areca catechu, 0.5-1 part of Cnidium monnieri, 0.5-1 part of Dictamni cortex and 0.5-1 part of Kochia scoparia.

[0032] In the following technical schemes, unless otherwise specified, the present invention has no special limitation on the sources of the raw materials, and any conventional commercially available product in the art may be used.

[0033] By weight, the Chinese medicine composition provided by the present invention includes 1.5 to 2 parts of Phellodendron chinense Schneid., which can be 1.8 to 2 parts. As an optional embodiment of the present invention, the Phellodendron chinense can be 1.5, 1.6, 1.7, 1.8, 1.9 and 2 parts. The Phellodendron chinense is bitter, cold, clears away heat and dries dampness, purges fire and detoxifies, and removes bone steaming. It is the dry bark of the Rutaceae plant Phellodendron chinense Schneid. or Phellodendron amurense Rupr.

[0034] Based on the mass of Phellodendron chinense, the Chinese medicine composition provided by the present invention includes 0.5-1 part of Scutellaria baicalensis, which can be 0.8-1 part. As an optional embodiment of the present invention, the Scutellaria baicalensis can be 0.5, 0.6, 0.7, 0.8, 0.9 and 1 part. The Scutellaria baicalensis: bitter, cold, heat-clearing and damp-drying, purging fire and detoxifying, hemostasis, and miscarriage-soothing, is the dried root of Scutellaria baicalensis Georgi. of the Labiatae family.

[0035] Based on the mass of Phellodendron chinense, the Chinese medicine composition provided by the present invention includes 0.5-1 part of Angelica sinensis, which can be 0.8-1 part. As an optional embodiment of the present invention, the Angelica sinensis can be 0.5, 0.6, 0.7, 0.8, 0.9 and 1 part. The Angelica sinensis: sweet, pungent, warm, blood-tonifying and menstruation-regulating, blood-activating and pain-relieving, intestinal-moistening and laxative, is the root of Angelica sinensis (Oliv.) Diels. of the Apiaceae family.

[0036] Based on the mass of Phellodendron chinense, the Chinese medicine composition provided by the present invention includes 1.5-2 parts of Sophora flavescens, which can be 1.8-2 parts. As an optional embodiment of the present invention, the Sophora flavescens can be 1.5, 1.6, 1.7, 1.8, 1.9 and 2 parts. The Sophora flavescens: bitter, cold in nature, heat-clearing and damp-drying, insecticidal, diuretic, is the dried root of the leguminous plant Sophora flavescensAit.

[0037] Based on the mass of Phellodendron chinense, the Chinese medicine composition provided by the present invention includes 0.5-1 part of Atractylodes lancea, which can be 0.8-1 part. As an optional embodiment of the present invention, the Atractylodes lancea can be 0.5, 0.6, 0.7, 0.8, 0.9 and 1 part. The Atractylodes lancea: pungent, bitter, warm, dry dampness and invigorate the spleen, dispel wind and dissipate cold, is the dried rhizome of Atractylodes lancea (Thunb.) DC. or Atractylodes chinensis (DC.) koiclz of the Asteraceae plant.

[0038] Based on the mass of Phellodendron chinense, the Chinese medicine composition provided by the present invention includes 0.5-1 part of Rhizoma Alismatis, which can be 0.8-1 part. As an optional embodiment of the present invention, the Rhizoma Alismatis can be 0.5, 0.6, 0.7, 0.8, 0.9 and 1 part. The Rhizoma Alismatis: sweet, cold, diuretic, heat-relieving, is the dried tuber of Alisma orientalis (Sam.) Juzep. of the Alismataceae family.

[0039] Based on the mass of Phellodendron chinense, the Chinese medicine composition provided by the present invention includes 0.6-0.9 parts of rhubarb, which can be 0.7-0.9 parts. As an optional embodiment of the present invention, the rhubarb can be 0.6, 0.7, 0.8 or 0.9 parts. The rhubarb is bitter, cold, purgative, purgative, heat-clearing, fire-clearing, blood-cooling, detoxifying, blood stasis and menstruation-promoting, and is the dried root and rhizome of Rheum palmatum L., Rheum tanguticum Maxim.ex Bal. or Rheum officinale Baill. of the Polygonaceae family.

[0040] Based on the mass of Phellodendron chinense, the Chinese medicine composition provided by the present invention includes 0.5-1 part of Saposhnikovia divaricata (Turcz.) Schischk, which is a dried root of the unflowered plant of Saposhnikovia divaricata (Turcz.) Schischk, a plant of the Umbelliferae family. As an optional embodiment of the present invention, the Saposhnikovia divaricata can be 0.5, 0.6, 0.7, 0.8, 0.9 and 1 part. The Saposhnikovia divaricata (Turcz.) Schischk is pungent, sweet, slightly warm, can dispel wind and relieve exterior symptoms, overcome dampness and relieve pain, and stop spasms.

[0041] Based on the mass of Phellodendron chinense, the Chinese medicine composition provided by the present invention includes 0.5-1 part of Corydalis yanhusuo, which can be 0.8-1 part. As an optional embodiment of the present invention, the Corydalis yanhusuo can be 0.5, 0.6, 0.7, 0.8, 0.9 and 1 part. The Corydalis yanhusuo: pungent, bitter, warm, blood-activating, qi-promoting, analgesic, is the dried tuber of Corydalis yanhusuo W.T.Wang, a plant of the Poppy family.

[0042] Based on the mass of Phellodendron chinense, the Chinese medicine composition provided by the present invention includes 0.5-1 part of betel nut, which can be 0.8-1 part. As an optional embodiment of the present invention, the betel nut can be 0.5, 0.6, 0.7, 0.8, 0.9 and 1 part. The betel nut is bitter, pungent, warm, insecticidal, detoxifying, qi-promoting, diuretic, and antimalarial, and is the dried mature seed of Areca catechu L., a plant of the palm family.

[0043] Based on the mass of Phellodendron chinense, the Chinese medicine composition provided by the present invention includes 0.5-1 part of Cnidium monnieri, which can be 0.8-1 part. As an optional embodiment of the present invention, the Cnidium monnieri can be 0.5, 0.6, 0.7, 0.8, 0.9 and 1 part. The Cnidium monnieri: pungent, bitter, warm, insecticidal and itchy, dry dampness and dispel wind, warm the kidney and strengthen yang, is the dried mature fruit of the Umbelliferae plant Cnidium monnieri (L.) Cuss.

[0044] Based on the mass of Phellodendron chinense, the Chinese medicine composition provided by the present invention includes 0.5-1 part of Dictamnus dasycarpus, which can be 0.8-1 part. As an optional embodiment of the present invention, the Dictamnus dasycarpus can be 0.5, 0.6, 0.7, 0.8, 0.9 and 1 part. The Dictamnus dasycarpus is bitter, cold, heat-clearing and damp-drying, wind-dispelling and detoxifying, and is the dried root bark of the Rutaceae plant Dictamnus dasycarpus Turcz.

[0045] Based on the mass of Phellodendron chinense, the Chinese medicine composition provided by the present invention includes 0.5-1 part of Kochia scoparia, which can be 0.8-1 part. As an optional embodiment of the present invention, the Kochia scoparia can be 0.5, 0.6, 0.7, 0.8, 0.9 and 1 part. The Kochia scoparia: pungent, bitter, cold, diuretic, stranguria, heat-clearing and dampness-removing, itching, is the dried mature fruit of the Chenopodiaceae plant Kochia scoparia (L.) Schrad.

[0046] The dosage of one dose of the traditional Chinese medicine composition of the present invention can be 100-150 g, or 149 g.

[0047] According to TCM theory, itching is caused by blood deficiency generating wind, wind prevailing with dampness, disturbing yin fluid, and malnutrition of the skin. The name pruritus was first seen in the Treatise on the Causes and Symptoms of Various Diseases, which called it "itchy wind, wind pruritus", and wind evil is the main pathogenic factor of skin pruritus. The Shengji Zonglu proposed that "blood vessels are stagnant, the inside and outside are agitated, and heat is generated, and heat causes itching". The Treatise on the Causes and Symptoms of Various Diseases records: "Wind pruritus is caused by the body being weak and affected by wind, which enters the skin and fights with qi and blood, and both travel between the skin. The evil qi is weak and cannot impact and cause pain, so it only causes itching". "Treatise on the Causes and Symptoms of Various Diseases·Wind Itching Symptoms" records that "evil qi invades the muscles, which makes the muscles weak, the true qi disperses, and the skin is attacked by cold, which spreads to the pores and closes the hair. The evil qi fights with the defensive qi, and the yang wins and the heat is generated, and the yin wins and the cold is generated; the cold makes the surface weak, and the weakness makes the evil qi come and go, so the flesh itches. All kinds of arthralgia, itching when encountering heat, and pain when encountering cold". The treatment should dispel wind and heat, remove dampness and stop itching. According to the theories of traditional Chinese medicine such as "blood deficiency generates wind, wind wins and dampness", "body weakness is affected by wind, wind enters the pores, and qi and blood fight against each other", the present invention creatively prepares a Chinese medicine composition for treating skin pruritus by combining Sophora flavescens, Phellodendron chinense, Scutellaria baicalensis with the effects of clearing heat and drying dampness, Dictamni cortex, Saposhnikovia divaricata, Cnidium monnieri and other medicinal materials with the effects of dispelling wind and detoxifying. In the prescription, Sophora flavescens, Phellodendron amurense and Scutellaria baicalensis are the monarchs, Dictamni cortex, Saposhnikovia divaricata and Cnidium monnieri are the ministers, and Angelica sinensis, Atractylodes lancea, Orientalis rhizome, Rhubarb, Corydalis yanhusuo, Areca nut and Kochia scoparia are the assistants. Sophora flavescens, Phellodendron amurense and Scutellaria baicalensis clear away heat and dampness, detoxify and kill insects; Dictamni cortex clears heat and dampness, dispels wind and detoxifies, Saposhnikovia divaricata dries dampness, dispels wind and relieves exterior symptoms, Cnidium monnieri kills insects and relieves itching, dries dampness and dispels wind, and assists Sophora flavescens, Phellodendron amurense and Scutellaria baicalensis in drying dampness, clearing heat and relieving itching; Atractylodes lancea strengthens the effect of Dictamni cortex and Saposhnikovia divaricata in dispelling wind and serves as the assistant; Orientalis rhizome promotes diuresis and eliminates dampness, Rhubarb clears heat and purges fire, cools blood and detoxifies, Angelica sinensis and Corydalis yanhusuo promote blood circulation and relieve pain, Areca nut promotes qi and diuresis, Kochia scoparia clears heat and dampness and relieves itching, and strengthens the monarch's function of clearing heat and relieving itching, serving as the assistants. The Chinese medicine composition provided by the present invention plays a role in treating skin itching under the comprehensive action of the medicine composition, and the Chinese medicine composition is suitable for treating itching symptoms caused by various skin diseases, such as systemic itching, skin disease itching, neurogenic itching, psychogenic itching, multi-factor itching and unexplained itching. The results of the examples of the present invention show that the Chinese medicine composition provided by the present invention has achieved good therapeutic effects in the external treatment of skin itching patients with traditional Chinese medicine.

[0048] The present invention has no special restrictions on the preparation method of the Chinese medicine composition, and any conventional preparation method in the art can be used. As an optional embodiment of the present invention, the Chinese medicine composition can be obtained by directly mixing the corresponding raw materials and then crushing them; or the raw materials can be crushed and then mixed to obtain the corresponding Chinese medicine composition; or the raw materials can be mixed and then decocted to obtain the corresponding Chinese medicine composition.

[0049] The present invention provides a method for preparing the Chinese medicine composition described in the above technical solution, comprising:

[0050] The raw materials are mixed with water and soaked, and then first decocted to obtain a first decocted medicinal liquid and medicinal residues;

[0051] The obtained medicinal residue is mixed with water for a second decoction to obtain a second decoction medicinal liquid;

[0052] The first decoction liquid and the second decoction liquid are mixed to obtain a Chinese medicine composition.

[0053] The present invention mixes the raw materials with water and soaks them, then performs a first decoction to obtain a first decoction liquid and a medicine residue. When the present invention mixes the raw materials with water; the water can be cold water; the amount of water added can soak the medicine surface by 1 to 3 cm, or can soak the medicine surface by 2 to 3 cm. After the present invention mixes the raw materials with water, it is preferred to soak them first; the soaking time can be 30 minutes. After the soaking is completed, the present invention preferably boils the obtained soaking liquid and then performs the first decoction. The present invention can use a high fire for boiling; a low fire can be used to maintain a slight boil during the first decoction; the first decoction time can be 30 minutes. After the first decoction is completed, the present invention preferably separates the medicine residue and the liquid, and the obtained liquid is the first decoction liquid.

[0054] The present invention mixes the obtained medicinal residue with water for a second decoction to obtain a second decocted medicinal liquid. When the present invention mixes the obtained medicinal residue with water, the amount of water added can soak the medicinal surface by 1 to 3 cm, or by 1 to 2 cm. After the obtained medicinal residue is mixed with water, the obtained medicinal residue-water mixed system is boiled and then subjected to a second decoction. The present invention can use a high fire for boiling; during the second boiling process, a low fire can be used to maintain a slight boil; the second decoction time can be 15 to 25 minutes, or 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 or 25 minutes. After the second decoction is completed, the present invention obtains a second decocted medicinal liquid by solid-liquid separation.

[0055] After obtaining the first decoction liquid and the second decoction liquid, the present invention mixes the first decoction liquid and the second decoction liquid. After mixing the first decoction liquid and the second decoction liquid, the present invention preferably further comprises filtering, packaging and cooling the obtained liquid to obtain a Chinese medicine composition.

[0056] The Chinese medicine composition prepared by the preparation method of the present invention is a decoction and / or a fumigation preparation. In the present invention, the method of using the decoction and / or the fumigation preparation can be to use it directly on the affected part. The method of using the decoction and / or the fumigation preparation of the present invention can also be to pour the decoction and / or the fumigation preparation into a container, then pour warm water into it to dilute it, and use the obtained dilution to directly wash and soak the itchy part. As an optional embodiment of the present invention, the temperature of the warm water can be about 40°C. As an optional embodiment of the present invention, when the decoction is mixed with warm water, the volume of the decoction can be>0 and ≤1 part; the volume of the warm water can be 1 to 10 parts, or 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 parts. When the decoction and / or the fumigation preparation are prepared in the present invention, the dosage of the raw materials of the Chinese medicine composition can be 100 to 150g, or 149g. That is, the present invention mixes 100-150g of the raw material with water and soaks for 30 minutes before decocting, decocting twice in total, and mixing the decoctions obtained from the two decoctions to obtain a decoction and / or fumigation preparation; the decoction and / or fumigation preparation is a daily dosage; the decoction is used twice, morning and evening.

[0057] The present invention also provides the use of the Chinese medicine composition described in the above technical solution or the Chinese medicine composition prepared by the preparation method described in the above technical solution in the preparation of a drug for treating skin itching. In the present invention, the drug includes an external preparation; the external preparation includes any one or more of a decoction, a fumigation preparation, a powder and a granule. In the present invention, the skin pruritus includes any one or more of systemic pruritus, anal pruritus, dermatosis pruritus, neurogenic pruritus, psychogenic pruritus, multifactorial pruritus and unexplained pruritus.

[0058] In order to further illustrate the present invention, the technical solution provided by the present invention is described in detail below in conjunction with the accompanying drawings and embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0059] Example 1

[0060] A Chinese medicine composition, wherein the raw materials of the Chinese medicine composition are as follows:

[0061] Phellodendron 20g, Scutellaria 10g, Angelica 10g, Sophora flavescens 20g, Atractylodes 10g, Alisma orientalis 10g, Rhubarb 9g, Saposhnikovia 10g, Corydalis 10g, Areca 10g, Cnidium monnieri 10g, Dictamni cortex 10g and Kochia scoparia 10g.

[0062] The preparation method of the Chinese medicine composition is as follows Figure 1 The specific steps are as follows:

[0063] After mixing the raw materials of a Chinese medicine composition, add clean water to allow the clean water to soak the medicine surface by 2 to 3 cm, and soak for 30 minutes. After the soaking is completed, directly boil the mixed system over high heat, and then simmer on low heat for 30 minutes. This is the first decoction. After the first decoction is completed, separate the solid-liquid obtained medicinal liquid and medicinal residue; the obtained medicinal liquid is the first decoction liquid; add water to the obtained medicinal residue until the water soaks the medicine surface by 1 to 2 cm, then boil the medicinal residue water mixed system over high heat, and then simmer on low heat for 15 to 25 minutes. After the decoction is completed, separate the solid-liquid, and the obtained liquid is the second decoction liquid. Mix the first decoction liquid and the second decoction liquid, package, and cool to obtain a decoction of the Chinese medicine composition. The finished decoction is shown in the figure below. Figure 2 shown.

[0064] Example 2

[0065] A Chinese medicine composition, calculated by weight, consisting of:

[0066] 2 parts of Phellodendron chinense, 1 part of Scutellaria baicalensis, 1 part of Angelica sinensis, 2 parts of Sophora flavescens, 1 part of Atractylodes macrocephala, 1 part of Alisma orientalis, 0.9 part of Rhubarb, 1 part of Saposhnikovia divaricata, 1 part of Corydalis yanhusuo, 1 part of Areca catechu, 1 part of Cnidium monnieri, 1 part of Dictamni cortex and 1 part of Kochia scoparia.

[0067] The preparation method of the Chinese medicine composition is:

[0068] The above Chinese medicinal materials are dried, crushed, mixed evenly and packaged to obtain the powder of the Chinese medicinal composition.

[0069] Example 3

[0070] A Chinese medicine composition, wherein the raw materials of the Chinese medicine composition are as follows:

[0071] Phellodendron 15g, Scutellaria 5g, Angelica 5g, Sophora flavescens 15g, Atractylodes 5g, Alisma orientalis 5g, Rhubarb 6g, Saposhnikovia 5g, Corydalis 5g, Areca 5g, Cnidium monnieri 5g, Dictamni cortex 5g and Kochia scoparia 5g.

[0072] The preparation method of the Chinese medicine composition is the same as that of Example 1.

[0073] Example 4

[0074] A Chinese medicine composition, wherein the raw materials of the Chinese medicine composition are as follows:

[0075] Phellodendron 18g, Scutellaria 8g, Angelica 8g, Sophora flavescens 18g, Atractylodes 8g, Alisma orientalis 8g, Rhubarb 7g, Saposhnikovia 8g, Corydalis 8g, Areca 8g, Cnidium monnieri 8g, Dictamni cortex 8g and Kochia scoparia 8g.

[0076] The preparation method of the Chinese medicine composition is the same as that of Example 1.

[0077] Application Example 1

[0078] Clinical effect test of the Chinese medicine composition provided by the present invention on anal pruritus

[0079] 1. Case

[0080] 100 patients with anal pruritus, all of whom were adults of all ages, were randomly divided into two groups, treatment group 1 and treatment group 2, with 50 cases in each group.

[0081] 2. Symptom scores were calculated for the patients in the two experimental groups before and after treatment.

[0082] Symptom score: The patient is scored based on the severity of the pruritus symptoms (itching site, itching frequency, itching degree and sleep disturbance) and skin lesion symptoms (lesion area, lesion severity). The higher the score, the more obvious the symptom.

[0083] Symptom scoring indicators: (i) The scoring range of the itching site is 1 to 3 points, with no itching at any site being 1 point; itching at one site being 2 points; and itching all over the body being 3 points. (ii) The scoring range of the itching frequency is 1 to 5 points, with no itching being 1 point; 5 itching times of 10 minutes being 2 points; and itching that persists being 5 points. (iii) The degree of itching is scored from 1 to 5 points based on the severity of the itching, with no itching being 1 point; mild itching that is tolerable and can be relieved by patting being 2 points; obvious itching that cannot be stopped from scratching, and scratching that induces mild secondary rash being 3 points; severe itching that affects the patient's sleep and work, and produces local scratching that induces obvious secondary rash being 4 points; more severe itching that affects the patient's sleep and work, and there is anxiety and secondary rash being 5 points. (IV) The score range for the impact on sleep is 0 to 6 points, with no impact being 0 points; the number of times you wake up due to itching during sleep is 1 point; more than 3 times is 6 points. (V) Skin lesion symptom score. The indicators are divided into skin lesion area and severity (erythema, edema / infiltration / papule, scaling, lichenification). ① Skin lesion area assessment criteria: no skin lesions are 0 points; skin lesion area < 35% of body surface area is 1 point; skin lesion area occupies 35% to 65% of the body surface area is 2 points; the proportion of skin lesion area to body surface area> 65% is 3 points. ② Assessment criteria for the severity of skin lesions: 0 points for no obvious pigmentation changes; 1 point for light red spots, local dermal edema that is difficult to touch, local mild desquamation and fine scales, slightly thickened skin lines, and a vague feeling of itching but no scratching; 2 points for obvious redness, clear dermal edema in multiple places, coarse desquamation and scales in multiple places on the body, and thickened skin lines in a cross-like shape; 3 points for bright red or dark red color, widespread dermal edema and infiltration, significant desquamation and thickening of scales in most parts of the body, and significant thickening of skin lines in a deep cross-like shape.

[0084] The total score of this symptom scoring index ranges from 3 to 25 points, and the higher the score, the more severe the skin itching.

[0085] 3. Treatment methods of the two experimental groups

[0086] Treatment group 1: Patients use the decoction of Example 1, one dose per day (the decoction of Example 1 is one dose or one set), and each dose is divided into two times a day, morning and evening, and each time is 10 minutes. The specific method of use is to mix the decoction with warm boiled water at 40°C, and the volume of the decoction can be >0 and ≤1 part during mixing; the volume of the warm boiled water is 1 to 10 parts, and the ratio is adjusted according to the specific situation. If the wound is small, the liquid medicine is heated and used directly. In the case of a large wound, after mixing the warm boiled water and the decoction, the itchy area is directly fumigated and bathed.

[0087] Treatment group 2: Patients were given an external ointment, namely, compound phellodendron liquid ointment, and used according to the instructions.

[0088] The two experimental groups were treated with the drug for 2 consecutive weeks.

[0089] 4. Comparison of symptom relief between the two trial groups

[0090] (1) The symptom scores of the two experimental groups before and after treatment are shown in Table 1.

[0091] Table 1 Symptom scores of patients in the two experimental groups before and after treatment (points)

[0092] Group Number of cases Symptom score before treatment Symptom score after treatment Symptom improvement score Treatment Group 1 50 14.06 6.6 7.46 Treatment Group 2 50 13.56 8.02 5.54

[0093] As can be seen from Table 1, the Chinese medicine composition provided by the present invention can significantly alleviate the symptoms of anal itching.

[0094] (2) Comparison of clinical efficacy between the two trial groups

[0095] The four-level assessment is cured, markedly effective, effective, and ineffective. Cured: Itching and skin lesions completely disappear, and the TCM symptom score decreases by ≥90%. Markedly effective: The patient's skin lesions and itching symptoms disappear, and the TCM symptom score decreases by ≥50% and <90%. Effective: The patient's skin lesions and itching symptoms are alleviated, and the TCM symptom score decreases by ≥30% and <50%. Ineffective: The patient's skin lesions and itching symptoms remain unchanged, and the TCM symptom score decreases by <30%. Total effective = cured + markedly effective + effective.

[0096] The comparison of clinical efficacy between the two experimental groups is shown in Tables 2-3.

[0097] Table 2 Comparison of clinical efficacy of patients in the two experimental groups (number of cases)

[0098]

[0099] Table 3 Comparison of clinical efficacy between the two groups of patients (%)

[0100]

[0101] As shown in Tables 2 to 3, the cure rate of the Chinese medicine composition provided by the present invention in treating anal skin pruritus is as high as 80%, and the total effective rate is as high as 98%. The Chinese medicine composition provided by the present invention is significantly better than conventional external medicaments for skin pruritus in treating anal skin pruritus.

[0102] Application Example 2

[0103] Examples of clinical application effects of the Chinese medicine composition provided by the present invention

[0104] Case Report 1

[0105] 1. Basic information of the patient

[0106] Name: Grandma Wang;

[0107] Age: 85 years old

[0108] Occupation: None.

[0109] 2. Chief complaint and medical history

[0110] Chief complaint: The patient reported that he had repeated symptoms of anal itching, pain and discomfort in the past two years, which had seriously affected his daily life and work.

[0111] Medical history: Two years ago, due to her old age and reduced activity, she spent more time sitting and lying down, and began to experience anal itching. She had used topical corticosteroid ointment for a long time, but the symptoms recurred, and she experienced anal pain, dampness and discomfort.

[0112] 3. Condition before treatment

[0113] (1) Symptoms: Circular itching around the anus, persistent attacks, scratching the anus with hands when it is unbearable. Specialist: Assist the patient to lie on the left side, obvious edema of the skin folds around the anus, moist perianal area, multiple chapped skin lesions around the anus, and scales on the edges of the lesions. The symptom score before treatment was 15 points. Figure 3 shown.

[0114] (2) Sleep quality: Severe impact on sleep, difficulty sleeping at night, easy waking, and lack of energy the next day. The impact of the disease on sleep quality is scored as 6 points.

[0115] (3) Skin lesion symptom score: When the perianal itching is unbearable, the patient scratches the perianal area with his hands. If cracks and rashes appear at the scratched area, the score is 2 points.

[0116] Skin lesion symptom scoring. The indicators are divided into skin lesion area and severity (erythema, edema / infiltration / papule, scales, lichenification). ① Lesion area assessment criteria: no skin lesions are 0 points; skin lesion area <35% of body surface area is recorded as 1 point; skin lesion area occupies 35% to 65% of the surface area is recorded as 2 points; skin lesion area occupies more than 65% of the body surface area is recorded as 3 points. ② Lesion severity assessment criteria: no obvious pigmentation change is 0 points; light red spots, local dermal edema that is not easy to touch, local mild desquamation and fine scales, slightly thickened skin texture, vague itching but not scratched are recorded as 1 point; obvious redness, clear dermal edema in multiple places, coarse desquamation and scales can be seen in many places on the body, and skin texture thickening is cross-shaped, which is recorded as 2 points; bright red or dark red color, extensive dermal edema and infiltration, significant desquamation and thickening of scales in most parts of the body, and significant thickening of skin texture with deep cross-shaped is recorded as 3 points.

[0117] 4. Treatment process

[0118] The patient was given a decoction of the Chinese medicine composition of Example 1 for treatment, one dose per day, fumigation and sitting bath twice a day in the morning and evening, each time for 10 minutes. The decoction was mixed with 40° C. warm water in a volume ratio of 1:8 and then fumigation and sitting bath were performed.

[0119] 5. Post-treatment condition

[0120] (1) Symptom relief:

[0121] One week later: The perianal dampness was significantly relieved, with slight itching, and no significant impact on sleep. The symptom score dropped to 4 points after treatment. Figure 4 shown.

[0122] Two weeks later: The symptoms basically disappeared, there was no obvious itching, and a few scales were visible on the perianal skin. The symptom score dropped to 1 point.

[0123] In summary, the Chinese medicine composition provided by the present invention can be used as an external medicine for treating skin itching, especially anal skin itching.

[0124] Although the above embodiment describes the present invention in detail, it is only a part of the embodiments of the present invention, not all of the embodiments. People can also obtain other embodiments based on this embodiment without creativity, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition, characterized in that: The raw materials used for preparation include, by weight: 1.5-2 parts of Phellodendron chinense, 0.5-1 part of Scutellaria baicalensis, 0.5-1 part of Angelica sinensis, 1.5-2 parts of Sophora flavescens, 0.5-1 part of Atractylodes lancea, 0.5-1 part of Alisma orientalis, 0.6-0.9 part of Rhubarb, 0.5-1 part of Saposhnikovia divaricata, 0.5-1 part of Corydalis yanhusuo, 0.5-1 part of Areca catechu, 0.5-1 part of Cnidium monnieri, 0.5-1 part of Dictamni cortex and 0.5-1 part of Kochia scoparia.

2. The Chinese medicine composition according to claim 1, characterized in that: The raw materials used for preparation include, by weight: 1.8-2 parts of Phellodendron chinense, 0.8-1 part of Scutellaria baicalensis, 0.8-1 part of Angelica sinensis, 1.8-2 parts of Sophora flavescens, 0.8-1 part of Atractylodes lancea, 0.8-1 part of Alisma orientalis, 0.7-0.9 part of Rhubarb, 0.8-1 part of Saposhnikovia divaricata, 0.8-1 part of Corydalis yanhusuo, 0.8-1 part of Areca catechu, 0.8-1 part of Cnidium monnieri, 0.8-1 part of Dictamni cortex and 0.8-1 part of Kochia scoparia.

3. The Chinese medicine composition according to claim 1, characterized in that: The raw materials used for preparation include, by weight: 2 parts of Phellodendron chinense, 1 part of Scutellaria baicalensis, 1 part of Angelica sinensis, 2 parts of Sophora flavescens, 1 part of Atractylodes macrocephala, 1 part of Alisma orientalis, 0.9 part of Rhubarb, 1 part of Saposhnikovia divaricata, 1 part of Corydalis yanhusuo, 1 part of Areca catechu, 1 part of Cnidium monnieri, 1 part of Dictamni cortex and 1 part of Kochia scoparia.

4. The method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The following steps are involved: The raw materials are mixed with water and soaked, and then first decocted to obtain a first decocted medicinal liquid and medicinal residues; The obtained medicinal residue is mixed with water for a second decoction to obtain a second decoction medicinal liquid; The first decoction liquid and the second decoction liquid are mixed to obtain a Chinese medicine composition.

5. The preparation method according to claim 4, characterized in that: The first decoction time is 30 minutes; the second decoction time is 15 to 25 minutes.

6. The preparation method according to claim 4, characterized in that: During the first and second decoction processes, a low heat is used to maintain a slight boil.

7. The preparation method according to claim 4, characterized in that: When the raw materials are mixed with water or the obtained medicinal residues are mixed with water, the amount of water added is such that the water covers the medicinal surface by 1 to 3 cm.

8. Use of the Chinese medicine composition according to any one of claims 1 to 3 or the Chinese medicine composition prepared by the preparation method according to any one of claims 4 to 7 in the preparation of a drug for treating skin itching.

9. The use according to claim 8, characterized in that: The pruritus includes any one or more of systemic pruritus, anal pruritus, dermatosis pruritus, neuropathic pruritus, psychogenic pruritus, multifactorial pruritus and unexplained pruritus.

10. The use according to claim 8, characterized in that: The medicine includes an external preparation; the external preparation includes any one or more of a decoction, a fumigation preparation, a powder and a granule.

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