Multifunctional posterior sclera reinforcement biomaterial with controllable mechanical and degradation properties and preparation method thereof

By constructing a multifunctional biomaterial with photocrosslinked silk fibroin microgrooves and a sodium hyaluronate adhesion layer on a SIS membrane, the problems of insufficient biocompatibility and degradation performance of existing posterior scleral reinforcement materials have been solved, achieving efficient tissue regeneration and mechanical matching, and improving the treatment effect of pathological high myopia.

CN119701097BActive Publication Date: 2026-07-03BEIHANG UNIV
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Patent Information

Application Number
CN202411929979.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-12-25
Publication Date
2026-07-03
Estimated Expiration
2044-12-25

AI Technical Summary

Technical Problem

Existing posterior scleral reinforcement materials are inadequate in terms of biocompatibility, degradation performance, and mechanical properties, making it difficult to meet the treatment needs of patients with pathological high myopia.

Method used

A layer-by-layer self-assembly technique was used to construct a photocrosslinked silk fibroin microgroove coating and a sodium hyaluronate adhesion layer on a SIS membrane, forming a multifunctional biomaterial of SFMA/LbL/SIS/SH, thereby regulating the mechanical properties and degradation rate of the material.

Benefits of technology

A multifunctional posterior scleral reinforcement material with high biocompatibility, controllable mechanical properties, and degradation performance has been developed, promoting tissue regeneration and integration and improving the treatment effect of PSR surgery.

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Abstract

The application discloses a multifunctional biomaterial for posterior sclera reinforcement, which is prepared by using layer-by-layer self-assembly (LbL) surface functionalization technology to coat silk fibroin (SF) on the surface of small intestinal submucosa (SIS), and preparing a light cross-linked SF (SFMA) microgroove coating with anisotropic characteristics on one side of the SIS for guiding cell arrangement and growth, promoting tissue regeneration and repair; and preparing a light cross-linked SF and sodium hyaluronate (SF-SH) mixed coating on the other side for improving biocompatibility and adhesion, so as to realize preparation of a multifunctional posterior sclera reinforcement biomaterial with controllable mechanical and degradation properties and capable of promoting surrounding tissue regeneration. The posterior sclera reinforcement biomaterial is cross-linked in the LbL mode to avoid toxic substance residues generated by cross-linking of SIS and traditional glutaraldehyde. The light cross-linked SFMA microgroove coating on one side can not only realize directional growth of fibroblasts, but also realize directional arrangement of collagen type I secreted by the cells, and effectively realize tissue integration. Meanwhile, the light cross-linked SF-SH mixed coating on the other side has excellent adhesion, which is helpful for positioning and attaching of the reinforcement material, and is of great significance to improving the effect of a posterior sclera reinforcement (PSR) operation and promoting long-term stable and effective treatment of pathological high myopia by using the biomaterial.
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