Pharmaceutical composition for treating bone joint injury and preparation method thereof

Abstract

The invention relates to the technical field of medicines, and provides a pharmaceutical composition for treating osteoarticular injury. Comprising the following raw materials in parts by weight: 10-20 parts of prepared rehmannia root, 8-15 parts of angelica sinensis, 6-12 parts of ligusticum wallichii, 8-15 parts of radix paeoniae alba, 10-18 parts of codonopsis pilosula, 12-20 parts of astragalus membranaceus, 10-18 parts of teasel root, 10-18 parts of rhizoma drynariae, 6-12 parts of ground beetle, 5-10 parts of frankincense, 5-10 parts of myrrh, 3-8 parts of native copper, 8-15 parts of radix achyranthis bidentatae, 8-15 parts of pawpaw, 8-15 parts of radix clematidis, 10-18 parts of eucommia ulmoides, 10-18 parts of loranthus parasiticus and 6-12 parts of radix saposhnikoviae. The pharmaceutical composition for bone joint injury follows the traditional Chinese medicine theory and scientific compatibility, can quickly improve blood circulation, promote healing and reduce the possibility of disease relapse, and has the advantages of small side effect, high safety, scientific preparation method, accurate control of each condition, full retention of the drug effect, facilitation of human body absorption, and no toxic or side effect. The medicine can quickly and accurately act on the bone joint injury part, the treatment effect is improved, and an efficient and reliable treatment scheme is provided for a patient.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical technology, in particular to a pharmaceutical composition for treating bone and joint injuries and a preparation method thereof. Background Art

[0002] Bone and joint diseases have a high incidence rate in the human population, which is extremely harmful to the health of patients and is a stubborn disease. Many factors such as cold, dampness, and wind can damage the human body, causing poor blood circulation, poor qi and blood balance, and blocked meridians, which can lead to muscle soreness, numbness, burning pain, redness, swelling, hyperplasia, and deformation of the bones and joints. In severe cases, the neck, waist, and legs become stiff.

[0003] At present, Western medicine adopts analgesic therapy for bone and joint diseases, although it can quickly relieve pain, but in most cases, it only treats the symptoms but not the root cause, and it is difficult to achieve recovery, and analgesics are strong to stomach irritation, while increasing the patient's pain, increase its economic burden, and the curative effect is not satisfactory. Chinese medicine scientists usually use the method of removing rheumatism, stopping arthralgia, relaxing muscles and strengthening bones, and promoting blood circulation and removing blood stasis to treat, although some patients' symptoms can be improved, pathogenic factors are often difficult to thoroughly eliminate, clinically, after many patients have been treated for a long time, although the original symptoms have relief, the overall cure rate is not good enough, the condition is protracted and difficult to heal, and dual torture is brought to the patient's body and mind, and moreover, some drugs contain hormone components or need to cooperate with hormone drugs for long-term use, and the toxic and side effects of hormones not only damage the patient's body, but also set obstacles for subsequent medication. In view of the many defects in the prior art, a new and efficient bone and joint injury treatment scheme is urgently needed, so the present invention arises at the historic moment. Summary of the invention

[0004] In view of the deficiencies of the prior art, the present invention provides a pharmaceutical composition for treating bone and joint injuries and a preparation method thereof, which solves the common problems of the prior art in treating and alleviating bone and joint injuries that the drugs are only symptomatic and not curative and have significant side effects.

[0005] To achieve the above objectives, the present invention is implemented through the following technical scheme: a pharmaceutical composition for treating bone and joint injuries, comprising the following raw materials in parts by weight: 10-20 parts of Rehmannia root, 8-15 parts of Angelica sinensis, 6-12 parts of Ligusticum chuanxiong, 8-15 parts of White Peony Root, 10-18 parts of Codonopsis pilosula, 12-20 parts of Astragalus membranaceus, 10-18 parts of Dipsacus asper, 10-18 parts of Drynaria fortunei, 6-12 parts of Eupolyphaga sinensis, 5-10 parts of Frankincense, 5-10 parts of Myrrh, 3-8 parts of Natural Copper, 8-15 parts of Achyranthes bidentata, 8-15 parts of Papaya, 8-15 parts of Clematis chinensis, 10-18 parts of Eucommia ulmoides, 10-18 parts of Viscum album, and 6-12 parts of Saposhnikovia divaricata.

[0006] Preferably, the prepared rehmannia root is 12-18 parts, angelica root is 10-13 parts, ligusticum chuanxiong is 8-10 parts, white peony root is 10-13 parts, codonopsis pilosula is 12-16 parts, astragalus root is 14-18 parts, dipsaccharum officinale is 12-16 parts, drynariae rhizome is 12-16 parts, earthworm is 8-10 parts, frankincense is 6-8 parts, myrrh is 6-8 parts, natural copper is 4-6 parts, Achyranthes bidentata is 10-13 parts, papaya is 10-13 parts, clematis root is 10-13 parts, eucommia ulmoides is 12-16 parts, mistletoe is 12-16 parts, and siler is 8-10 parts.

[0007] Preferably, a method for preparing a pharmaceutical composition for treating bone and joint injuries comprises the following steps:

[0008] S1. Weigh all the raw materials according to the formula, wash and dry the Chinese medicinal materials except frankincense, myrrh and natural copper, and grind them into coarse powder;

[0009] S2. The crude powder is placed in an extraction tank, 6-10 times the amount of water is added, soaked for 1-2 hours, then heated to boiling, kept slightly boiling for 1-3 hours, filtered, and the filtrate is collected;

[0010] S3. Add 4-8 times the amount of water to the residue, repeat the operation of S2, and combine the two filtrates;

[0011] S4. The filtrate is concentrated under reduced pressure to a clear paste having a relative density of 1.05-1.15;

[0012] S5. Grind frankincense, myrrh and natural copper into fine powder, pass through a 80-120 mesh sieve, add to the above-mentioned clear paste, stir evenly, and prepare a pharmaceutical composition.

[0013] Preferably, in S2, 8 times the amount of water is added, soaked for 1.5 hours, heated to boiling, and kept slightly boiling for 2 hours.

[0014] Preferably, in S3, 6 times the amount of water is added to the filter residue.

[0015] Preferably, in S4, the filtrate is concentrated under reduced pressure to a clear paste having a relative density of 1.1.

[0016] Preferably, in S1, the coarse powder is crushed to be able to pass through a 20-40 mesh sieve.

[0017] Preferably, in S5, the frankincense, myrrh and native copper are crushed into fine powder and then passed through a 100-mesh sieve.

[0018] The present invention provides a pharmaceutical composition for treating bone and joint injuries and a preparation method thereof. The composition has the following beneficial effects:

[0019] 1. The pharmaceutical composition for treating bone and joint injuries provided by the present invention follows the scientific compatibility of traditional Chinese medicine theory. Medicinal materials such as Rehmannia root and Angelica sinensis that nourish blood and activate blood circulation work together with Codonopsis pilosula and Astragalus membranaceus that replenish qi, which can quickly activate the blood circulation in the injured area, deliver abundant nutrients to the damaged tissue in a short period of time, accelerate the healing of the damaged tissue, greatly shorten the recovery period, and quickly relieve the patient's pain. Medicinal materials such as Dipsacus asper, Drynaria fortunei, and Eupolyphaga sinensis that strengthen muscles and bones, remove blood stasis and heal injuries, target and directly attack the damaged bones and joints, quickly promote callus formation, enhance bone toughness, help to efficiently restore the structure and function of the bones and joints, and reduce the possibility of disease recurrence. In particular, it uses natural Chinese medicinal materials to minimize side effects and has high safety.

[0020] 2. The present invention is scientific and reasonable in preparation method, and strictly screens the processing conditions of each raw material. In the extraction process, the amount of water added, the soaking and decoction time are accurately controlled, which can fully dissolve the effective ingredients of the medicinal materials, avoid the loss of effective ingredients caused by excessive heating, and retain the efficacy to the greatest extent. After the special medicinal materials such as frankincense, myrrh, and natural copper are crushed into fine powder, they are added to the clear paste to ensure that the drugs are evenly dispersed, which is conducive to human absorption, so that the drugs can act quickly and accurately on the injured parts of the bone and joints, improve the treatment effect, and bring more efficient and reliable treatment plans for patients with bone and joint injuries. DETAILED DESCRIPTION

[0021] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0022] Embodiment 1:

[0023] The embodiment of the present invention provides a pharmaceutical composition for treating bone and joint injuries, including 100 grams of Rehmannia root, 80 grams of Angelica sinensis, 60 grams of Chuanxiong, 80 grams of White Peony Root, 100 grams of Codonopsis pilosula, 120 grams of Astragalus membranaceus, 100 grams of Dipsacus asper, 100 grams of Drynaria fortunei, 60 grams of Eupolyphaga sinensis, 50 grams of frankincense, 50 grams of Myrrh, 30 grams of natural copper, 80 grams of Achyranthes bidentata, 80 grams of Papaya, 80 grams of Clematis chinensis, 100 grams of Eucommia ulmoides, 100 grams of Viscum album, and 60 grams of Saposhnikovia divaricata.

[0024] Specifically, in this drug composition, each of the herbs complements each other and works together to treat bone and joint injuries. The Four-Substance Decoction composed of Rehmannia glutinosa, Angelica sinensis, Chuanxiong, and White Peony Root nourishes blood and activates blood circulation, providing a material basis for tendon and bone repair; Codonopsis pilosula and Astragalus membranaceus replenish qi, and qi can generate blood and circulate blood, helping qi and blood to circulate; Dipsacus asper, Drynaria fortunei, Eucommia ulmoides, and Viscum album replenish liver and kidney, and strengthen tendons and bones; Eupolyphaga sinensis, frankincense, myrrh, and natural copper activate blood circulation and remove blood stasis, and connect tendons and bones; Achyranthes bidentata leads the medicine downward, and can remove blood stasis and dredge meridians; Papaya and Clematis chinensis remove dampness and dredge collaterals, relieving joint cramps; Saposhnikovia divaricata removes wind and overcomes dampness, and works in synergy with all the herbs. The whole prescription is compatible, replenishes qi, blood, liver, and kidney, removes blood stasis, removes dampness, and dissipates wind, treating both the symptoms and the root causes, and promoting the recovery of bone and joint injuries in an all-round way.

[0025] A method for preparing a pharmaceutical composition for treating bone and joint injuries comprises the following steps:

[0026] Wash and dry the Chinese medicinal materials except frankincense, myrrh and natural copper, and grind them into coarse powder that can pass through a 20-mesh sieve;

[0027] Place the coarse powder in an extraction tank, add 600 ml of water, 6 times the amount, based on the total weight of the coarse powder of the Chinese medicinal materials, the same below, soak for 1 hour, then heat to boiling, keep it slightly boiling for 1 hour, filter, and collect the filtrate;

[0028] Add 400 ml of water to the residue, repeat the above heating and filtering operations, and combine the two filtrates;

[0029] The filtrate was concentrated under reduced pressure to a clear paste with a relative density of 1.05;

[0030] Grind frankincense, myrrh and natural copper into fine powder, pass through an 80-mesh sieve, add into the above-mentioned clear paste, stir evenly, and prepare a pharmaceutical composition.

[0031] Specifically, multiple Chinese medicinal materials are made into coarse powder, which can not only ensure that the effective ingredients are easy to dissolve, but also maintain a certain degree of structural integrity of the medicinal materials and avoid excessive impurities. Multiple times of water soaking combined with double heating and filtration can fully simulate the traditional decoction process, so that the yin-nourishing components of Rehmannia glutinosa and the qi-invigorating components of Astragalus membranaceus can be efficiently dissolved into the filtrate, and the medicinal efficacy can be extracted to the greatest extent. The filtrate is concentrated to a clear paste under reduced pressure, and the degree of concentration is accurately controlled to enrich the effective ingredients and retain appropriate fluidity for subsequent preparation. Frankincense, myrrh, and natural copper are crushed into fine powder and incorporated into the clear paste. The fine powder can be evenly dispersed to ensure the stable release of the active ingredients of the medicine, work together, and accurately target the injured parts of the bones and joints to assist in repair.

[0032] Embodiment 2:

[0033] The embodiment of the present invention provides a pharmaceutical composition for treating bone and joint injuries, including 150 grams of Rehmannia root, 120 grams of Angelica sinensis, 90 grams of Chuanxiong, 120 grams of White Peony Root, 150 grams of Codonopsis pilosula, 160 grams of Astragalus membranaceus, 150 grams of Dipsacus asper, 150 grams of Drynaria fortunei, 90 grams of Eupolyphaga sinensis, 80 grams of frankincense, 80 grams of Myrrh, 50 grams of natural copper, 120 grams of Achyranthes bidentata, 120 grams of Papaya, 120 grams of Clematis chinensis, 150 grams of Eucommia ulmoides, 150 grams of Viscum album, and 90 grams of Saposhnikovia divaricata.

[0034] A method for preparing a pharmaceutical composition for treating bone and joint injuries comprises the following steps:

[0035] Wash and dry the Chinese medicinal materials except frankincense, myrrh and natural copper, and crush them into coarse powder that can pass through a 30-mesh sieve;

[0036] Put the coarse powder into an extraction tank, add 800 ml of water, soak for 1.5 hours, heat to boiling, keep it slightly boiling for 2 hours, and filter to obtain the filtrate;

[0037] Add 600 ml of water to the residue, repeat the previous operation, and combine the filtrates;

[0038] The filtrate is concentrated under reduced pressure to a clear paste with a relative density of 1.1;

[0039] Frankincense, myrrh and natural copper are crushed into fine powder through a 100-mesh sieve, added into the clear paste and stirred evenly to prepare a medicine composition.

[0040] Embodiment three:

[0041] The embodiment of the present invention provides a pharmaceutical composition for treating bone and joint injuries, including 200 grams of Rehmannia root, 150 grams of Angelica sinensis, 120 grams of Chuanxiong, 150 grams of White Peony Root, 180 grams of Codonopsis pilosula, 200 grams of Astragalus membranaceus, 180 grams of Dipsacus asper, 180 grams of Drynaria fortunei, 120 grams of Eupolyphaga sinensis, 100 grams of frankincense, 100 grams of Myrrh, 80 grams of natural copper, 150 grams of Achyranthes bidentata, 150 grams of Papaya, 150 grams of Clematis chinensis, 180 grams of Eucommia ulmoides, 180 grams of Viscum album, and 120 grams of Saposhnikovia divaricata.

[0042] A method for preparing a pharmaceutical composition for treating bone and joint injuries comprises the following steps:

[0043] The Chinese medicinal materials except frankincense, myrrh and natural copper are washed, dried and crushed into coarse powder that can pass through a 40-mesh sieve;

[0044] Put the coarse powder into the extraction tank and add 1000 ml of water, soak for 2 hours, boil and then simmer for 3 hours, filter and collect the filtrate;

[0045] Add 800 ml of water to the residue, repeat the previous operation, and combine the filtrates;

[0046] The filtrate was concentrated under reduced pressure to a clear paste with a relative density of 1.15;

[0047] Frankincense and the like are crushed into fine powder through a 120-mesh sieve, and the powder is added into the clear paste and stirred evenly to obtain a pharmaceutical composition.

[0048] Embodiment 4:

[0049] The embodiment of the present invention provides a pharmaceutical composition for treating bone and joint injuries, including 120 grams of Rehmannia root, 100 grams of Angelica sinensis, 80 grams of Chuanxiong, 100 grams of White Peony Root, 120 grams of Codonopsis pilosula, 140 grams of Astragalus membranaceus, 120 grams of Dipsacus asper, 120 grams of Drynaria fortunei, 80 grams of Eupolyphaga sinensis, 60 grams of frankincense, 60 grams of Myrrh, 40 grams of natural copper, 100 grams of Achyranthes bidentata, 100 grams of Papaya, 100 grams of Clematidis, 120 grams of Eucommia ulmoides, 120 grams of Viscum album, and 80 grams of Saposhnikovia divaricata.

[0050] A method for preparing a pharmaceutical composition for treating bone and joint injuries comprises the following steps:

[0051] Wash, dry and grind the Chinese medicinal materials except frankincense, myrrh and natural copper into coarse powder with 25 mesh sieve;

[0052] Put the coarse powder into the extraction tank, add 700 ml of water, soak for 1.2 hours, boil it and then simmer for 1.5 hours, filter and take the filtrate;

[0053] Add 500 ml of water to the residue, repeat the previous operation, and combine the filtrates;

[0054] The filtrate was concentrated under reduced pressure to a clear paste with a relative density of 1.08;

[0055] Frankincense and other ingredients are crushed into fine powder through a 90-mesh sieve and then added to the clear paste and stirred evenly to prepare a pharmaceutical composition.

[0056] Embodiment five:

[0057] The embodiment of the present invention provides a pharmaceutical composition for treating bone and joint injuries, including 180 grams of Rehmannia root, 130 grams of Angelica sinensis, 100 grams of Chuanxiong, 130 grams of White Peony Root, 160 grams of Codonopsis pilosula, 180 grams of Astragalus membranaceus, 160 grams of Dipsacus asper, 160 grams of Drynaria fortunei, 100 grams of Eupolyphaga sinensis, 80 grams of frankincense, 80 grams of Myrrh, 60 grams of natural copper, 130 grams of Achyranthes bidentata, 130 grams of Papaya, 130 grams of Clematis chinensis, 160 grams of Eucommia ulmoides, 160 grams of Viscum album, and 100 grams of Saposhnikovia divaricata.

[0058] A method for preparing a pharmaceutical composition for treating bone and joint injuries comprises the following steps:

[0059] Except for frankincense, myrrh and natural copper, wash and dry the Chinese medicinal materials and crush them into coarse powder with a 35-mesh sieve;

[0060] Put the coarse powder into an extraction tank and add 900 ml of water, soak for 1.8 hours, boil and then simmer for 2.5 hours, filter to obtain the filtrate;

[0061] Add 700 ml of water to the residue, repeat the previous operation, and combine the filtrates;

[0062] The filtrate was concentrated under reduced pressure to a clear paste with a relative density of 1.12;

[0063] Frankincense and the like are crushed into fine powder through a 110-mesh sieve, and the powder is added into the clear paste and stirred to obtain a pharmaceutical composition.

[0064] Directions: Take the drug combination and brew it into tea with boiling water, 15 grams each time, twice a day, drink frequently instead of tea. Drink it as soon as possible after brewing to avoid long-term storage which may reduce the efficacy.

[0065] Note: Stop taking the medicine during the period of cold and fever. At this time, the body's positive energy is fighting against external pathogens. Taking this medicine combination may affect the recovery of the disease. Continue to use it after the fever subsides and the cold symptoms are relieved.

[0066] Keep a good mood during medication and avoid excessive mood swings. Bad mood may affect the body's blood circulation and be detrimental to the repair of bone and joint injuries.

[0067] Be careful when eating seafood during medication. Some seafood is irritating and may induce allergic reactions or aggravate osteoarthritis, affecting the effectiveness of drug treatment.

[0068] The pharmaceutical composition for treating bone and joint injuries prepared in this embodiment has shown a strong therapeutic effect in clinical applications. Detailed observation and follow-up records of more than 9,500 patients show that the average onset time is 11 days, the average cure time is 47 days, the total effective rate is as high as 99%, the total cure rate exceeds 93%, the drug allergy rate is maintained at about 0.2%, and the rest of the patients tolerated the drug well during the medication period without adverse reactions, which strongly proves the effectiveness and safety of the drug.

[0069] Relying on the profound accumulation of traditional Chinese medicine knowledge, the present invention accurately screens and cleverly combines various traditional Chinese medicines, and through rigorous proportions, enables them to exert unexpected synergistic effects, achieving significant breakthroughs in the field of bone and joint injury treatment, and has the outstanding characteristics of rapid onset of effect, controllable course of treatment and high cure rate.

[0070] Typical clinical cases are as follows:

[0071] Mr. Lu, male, 44 years old, a factory worker, suffered a hand injury while operating a machine, resulting in a fractured finger joint. He had poor recovery after surgery and suffered from joint stiffness and pain. He started taking this medicine in September 2018 and underwent rehabilitation training at the same time. Two months later, the flexibility of his finger joints was greatly improved, the pain was alleviated, and he was able to work normally.

[0072] Yan, female, 38 years old, a beautician, suffered from lumbar muscle strain due to long-term bending over work, lower back pain, and inability to straighten her back. She started taking this medicine in April 2019, combined with appropriate waist exercises. After one and a half months, her lower back pain was relieved, she was able to work with her back straight, her work efficiency was improved, and her living conditions improved.

[0073] Jiang, male, 50 years old, driver, suffered from cervical spondylosis due to long-term sitting, neck pain, dizziness, which affected driving safety. He received treatment with this drug in June 2020 and paid attention to adjusting his sitting posture. Two months later, his neck pain was relieved, the dizziness symptoms disappeared, he could drive safely without worries, and his life was back on track.

[0074] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A pharmaceutical composition for treating bone and joint injuries, characterized in that: The invention comprises the following raw materials in parts by weight: 10-20 parts of Rehmannia root, 8-15 parts of Angelica sinensis, 6-12 parts of Ligusticum chuanxiong, 8-15 parts of White Peony Root, 10-18 parts of Codonopsis pilosula, 12-20 parts of Astragalus membranaceus, 10-18 parts of Dipsacus asper, 10-18 parts of Drynaria fortunei, 6-12 parts of Eupolyphaga sinensis, 5-10 parts of Frankincense, 5-10 parts of Myrrha, 3-8 parts of Natural Copper, 8-15 parts of Achyranthes bidentata, 8-15 parts of Papaya, 8-15 parts of Clematis chinensis, 10-18 parts of Eucommia ulmoides, 10-18 parts of Viscum album and 6-12 parts of Saposhnikovia divaricata.

2. A pharmaceutical composition for treating bone and joint injuries and a preparation method thereof according to claim 1, characterized in that: The ingredients include 12-18 parts of Rehmannia root, 10-13 parts of Angelica sinensis, 8-10 parts of Ligusticum chuanxiong, 10-13 parts of White Peony Root, 12-16 parts of Codonopsis pilosula, 14-18 parts of Astragalus membranaceus, 12-16 parts of Dipsacus asper, 12-16 parts of Drynaria fortunei, 8-10 parts of Eupolyphaga sinensis, 6-8 parts of Olibanum, 6-8 parts of Myrrha, 4-6 parts of Copper Root, 10-13 parts of Achyranthes bidentata, 10-13 parts of Chaenomeles sinensis, 10-13 parts of Clematis chinensis, 12-16 parts of Eucommia ulmoides, 12-16 parts of Viscum album and 8-10 parts of Saposhnikovia divaricata.

3. A method for preparing a pharmaceutical composition for treating bone and joint injuries, using the pharmaceutical composition for treating bone and joint injuries as claimed in any one of claims 1 to 2, characterized in that: The following steps are involved: S1. Weigh all the raw materials according to the formula, wash and dry the Chinese medicinal materials except frankincense, myrrh and natural copper, and grind them into coarse powder; S2. The crude powder is placed in an extraction tank, 6-10 times the amount of water is added, soaked for 1-2 hours, then heated to boiling, kept slightly boiling for 1-3 hours, filtered, and the filtrate is collected; S3. Add 4-8 times the amount of water to the residue, repeat the operation of S2, and combine the two filtrates; S4. The filtrate is concentrated under reduced pressure to a clear paste having a relative density of 1.05-1.15; S5. Grind frankincense, myrrh and natural copper into fine powder, pass through a 80-120 mesh sieve, add to the above-mentioned clear paste, stir evenly, and prepare a pharmaceutical composition.

4. The method for preparing a pharmaceutical composition for treating bone and joint injuries according to claim 3, characterized in that: In S2, add 8 times the amount of water, soak for 1.5 hours, heat to boiling, and keep it boiling for 2 hours.

5. The method for preparing a pharmaceutical composition for treating bone and joint injuries according to claim 3, characterized in that: In S3, 6 times the amount of water is added to the filter residue.

6. The method for preparing a pharmaceutical composition for treating bone and joint injuries according to claim 3, characterized in that: In S4, the filtrate is concentrated under reduced pressure to a clear paste having a relative density of 1.

1.

7. The method for preparing a pharmaceutical composition for treating bone and joint injuries according to claim 3, characterized in that: In S1, the coarse powder is crushed to pass through a 20-40 mesh sieve.

8. The method for preparing a pharmaceutical composition for treating bone and joint injuries according to claim 3, characterized in that: In S5, the frankincense, myrrh and natural copper are crushed into fine powder and then passed through a 100-mesh sieve.