A sodium hyaluronate and a composition thereof

By esterifying all-trans retinoic acid and 13-cis retinoic acid with sodium hyaluronate to form a retinyl hyaluronate sodium derivative, and then forming a complex with polyol compounds, the stability and skin irritation issues of retinoic acid and isotretinoin when used topically are resolved, achieving oil control and acne removal effects, and making it suitable for a variety of topical skin products.

CN119798484BActive Publication Date: 2025-11-25SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES +1
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Patent Information

Application Number
CN202411907798.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-12-24
Publication Date
2025-11-25
Estimated Expiration
2044-12-24

AI Technical Summary

Technical Problem

Retinoic acid and isotretinoin have poor stability when used topically, are highly irritating to the skin, and have limited effects on controlling oil production. The efficacy of existing all-trans retinoic acid (HA) derivatives in the prevention and treatment of acne needs to be improved.

Method used

All-trans retinoic acid and 13-cis retinoic acid are simultaneously esterified with sodium hyaluronate to form a retinyl hyaluronate sodium derivative, which is then combined with a polyol compound to form a complex. The grafting rate and ratio of this compound on the skin surface are controlled to form a stable compound.

Benefits of technology

It improves the stability and antioxidant properties of sodium retinyl hyaluronic acid, significantly inhibits 5α-reductase, has a good oil-control effect, effectively prevents and treats acne, improves the skin's water-oil balance, reduces skin irritation, and is suitable for the preparation of a variety of topical skin products.

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Abstract

The present application provides a kind of retinyl hyaluronate sodium and its composition applied in the field of cosmetics and medicine.The retinyl hyaluronate sodium of the present application is characterized by all-trans retinoic acid and 13-cis retinoic acid esterification with sodium hyaluronate in a ratio of 1.5-3.0:1 (molar ratio), and the esterification degree is 1%-12%;The composition of the present application is characterized by retinyl hyaluronate sodium and polyol compound in a ratio of 1:1-10 (mass ratio).The retinyl hyaluronate sodium of the present application has significant effect in preventing and treating acne, and the composition is beneficial to improve the stability of retinyl hyaluronate sodium, prolong the shelf life of retinyl hyaluronate sodium raw material product.The retinyl hyaluronate sodium and its composition of the present application can be used for preparing whitening, anti-aging, oil control and acne-removing cosmetics and medical products.
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