Active component dissolving composition

Abstract

The invention discloses an active ingredient dissolving composition. The active ingredient dissolving composition comprises a component (a), a component (b) and a component (c), the component (a) comprises at least one long-chain fatty acyl acidic amino-acid ester; the component (b) comprises at least one polyol; the component (c) comprises at least one active matter and is selected from one or more of glycyrrhetinic acid, stearyl glycyrrhizinate, curcumin, tetrahydrocurcumin, resveratrol, glabridin, retinol and ceramide. The composition disclosed by the invention is very stable and good in safety.

Description

Technical Field

[0001] The present invention relates to an active ingredient dissolving composition, and more particularly to an active ingredient dissolving composition in the field of personal care products for beautifying and / or cleaning skin, eyes, teeth and / or hair. Background Art

[0002] Consumers have high expectations for the efficacy of personal care products, and product efficacy requires the use of many active ingredients. Many functional active ingredients are insoluble when added to personal care product formulas, such as resveratrol, glycyrrhetinic acid, curcumin, ceramide, etc. These useful active ingredients will precipitate when added to the formula, making the formula unstable. The precipitation of active ingredients also reduces the effect of the active ingredients.

[0003] Chinese patent CN118831018A uses a combination of octyldodecanol and 1,2-hexanediol to dissolve ceramide and achieves good results. However, due to safety issues, octyldodecanol is not recognized by consumers for use in personal care products.

[0004] Therefore, the present invention proposes a new technical solution to the above problems. Summary of the invention

[0005] The technical problem to be solved by the present invention is to overcome the deficiencies in the prior art and provide a technical solution for a safe active substance dissolving composition.

[0006] After a long period of research, the inventors have developed a method for obtaining an active substance dissolving composition by the following technical measures. The specific technical scheme is as follows:

[0007] In one aspect, the present invention provides an active ingredient dissolving composition comprising component (a), component (b) and component (c);

[0008] Component (a) includes at least one long-chain fatty acidic amino acid ester;

[0009] Component (b) includes at least one polyol having the general formula:

[0010]

[0011] Component (c) includes at least one active substance, and component (c) is selected from one or more of glycyrrhetinic acid, stearyl glycyrrhetinate, curcumin, tetrahydrocurcumin, resveratrol, glabridin, retinol, and ceramide; wherein the general formula of ceramide is as follows:

[0012]

[0013] As a preferred embodiment of the active ingredient dissolving composition of the present invention, the long-chain fatty acyl acidic amino acid ester has the following structural characteristics:

[0014] Ⅰ) The number of amino groups in the acidic amino acid part of its structure is less than the number of carboxyl groups, and the number of carbon atoms in the carbon chain of the acidic amino acid is 3 to 8. The acidic amino acids include their D-type, L-type and DL-type optical isomers; Ⅱ) The number of carbon atoms in the long-chain fatty acyl part of its structure is 8 to 22, and the long-chain fatty acyl is straight chain or branched.

[0015] Chain, the acyl group of long-chain fatty acyl comes from saturated or unsaturated fatty acids;

[0016] III) The ester group in its structure is an amino acid including two carboxyl groups and a saturated or

[0017] Unsaturated, straight-chain or branched fatty alcohol and / or the fatty alcohol is formed by adding a polyoxyalkylene group to a fatty alcohol ether having a molar number of 1 to 30 to form a monoester, diester or a mixture of a monoester and a diester of a fatty alcohol or a fatty alcohol ether,

[0018] The fatty alcohols and / or fatty alcohol ethers of the diesters are identical or different.

[0019] More preferably, the number of amino groups in the acidic amino acid portion is less than the number of carboxyl groups. For example, the amino acid structure has 1 amino group and 2 carboxyl groups. Of course, this patent is not limited to this.

[0020] Further preferably, the acidic amino acid is selected from one or more of aminomalonic acid, aspartic acid, glutamic acid, α-aminoadipic acid, β-aminoadipic acid, α-aminopimelic acid, β-aminopimelic acid, γ-aminopimelic acid, α-aminosuberic acid, β-aminosuberic acid, γ-aminosuberic acid, α-amino-α-methylsuccinic acid, γ-methylglutamic acid and γ-methyleneglutamic acid. Further preferably, the acidic amino acid part in its structure is preferably derived from L-glutamic acid.

[0021] Further preferably, the fatty acid is selected from the linear saturated fatty acids such as octanoic acid, nonanoic acid, decanoic acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, heptadecanoic acid, stearic acid, nonadecanoic acid, arachidic acid, heneicosanoic acid, behenic acid, butyl-5-methylpentanoic acid, 2-isobutyl-5-methylpentanoic acid, dimethyloctanoic acid, dimethylnonanoic acid, 2-butyl-5-methylhexanoic acid, methylundecanoic acid, dimethyldecanoic acid, 2-ethyl-3-methylnonanoic acid, 2,2-dimethyl-4-ethyloctanoic acid, methyldodecanoic acid, 2-propyl-3-methylnonanoic acid, methyltridecanoic acid, dimethyldodecanoic acid, 2-butyl-3-methylnonanoic acid, methyltetradecanoic acid, ethyltridecanoic acid, propyldodecano ... 2-(2-methylbutyl)-3-methylnonanoic acid, butylethylnonanoic acid, methylpentadecaic acid, ethyltetradecanoic acid, propyltridecanoic acid, butyldodecanoic acid, pentylundecanoic acid, hexyldecanoic acid, heptylnonanoic acid, dimethyltetradecanoic acid, butylpentylheptanoic acid, trimethyltridecanoic acid, methylhexadecanoic acid, ethylpentadecaic acid, propyltetradecanoic acid, butyltridecanoic acid, pentyldodecanoic acid, hexylundecanoic acid, heptyldecanoic acid, methylheptylnonanoic acid, dipentylheptanoic acid, methylheptadecaic acid, ethylhexadecanoic acid, propylpentadecaic acid, butyltetradecanoic acid, pentyltridecanoic acid, hexyldodecanoic acid, heptylundecanoic acid, octyldecanoic acid, dimethylhexadecanoic acid, methyl Branched chain saturated fatty acids such as octyl nonanoic acid, methyl octadecanoic acid, ethyl heptadecanoic acid, dimethyl heptadecanoic acid, methyl octyl decanoic acid, methyl nonadecanoic acid, dimethyl octadecanoic acid, butyl heptadecanoic acid, methyl eicosanoic acid, dimethyl nonadecanoic acid, nonyl lauric acid, dimethyl arachidic acid, hexyl hexadecanoic acid, etc.; straight chain monoenoic acids such as octenoic acid, nonenoic acid, decenoic acid, undecenoic acid, lauric acid, tridecenoic acid, myristoleic acid, pentadecenoic acid, hexadecenoic acid, heptadecanoic acid, octadecenoic acid, oleic acid, nonadecanoic acid, etc.; methyl heptadecanoic acid, methyl nonenoic acid, methyl undecenoic acid, dimethyl decenoic acid, methyl dodecenoic acid, methyl tridecenoic acid, dimethyl dodecenoic acid, dimethyl tridecenoic acid, methyl octadecenoic acid, dimethyl heptadecanoic acid The acyl groups of fatty acids such as branched chain monoenoic acid such as oleic acid, ethyl octadecenoic acid, polyenoic acid such as linoleic acid, trans-linoleic acid, linolenic acid, 9,12,15-octadecatrienoic acid, 10,12,14-octadecatrienoic acid, parinaoleic acid, arachidonic acid, coconut oil fatty acid, palm oil fatty acid, palm kernel oil fatty acid, corn oil fatty acid, peanut oil fatty acid, cottonseed oil fatty acid, linseed oil fatty acid, sunflower oil fatty acid, soybean oil fatty acid, sesame oil fatty acid, castor oil fatty acid, olive oil fatty acid, tea seed oil fatty acid, tallow fatty acid, hydrogenated tallow fatty acid, lard fatty acid, fish oil fatty acid, and mixtures of the above various fatty acids. It is further preferred that the long-chain fatty acyl part of its structure is derived from the acyl group of a straight-chain saturated fatty acid with 12 carbon atoms. Specifically, such as lauroyl.

[0022] Further preferably, the linear or branched, saturated or unsaturated fatty alcohol and / or fatty alcohol ether is selected from octanol, 2-ethylhexanol, secondary octanol, isooctyl alcohol, nonanol, secondary nonanol, 1-decanol, isodecyl alcohol, secondary decanol, undecanol, secondary undecanol, 2-methyldecanol, lauryl alcohol, secondary dodecanol, 1-tridecanol, isotridecyl alcohol, myristyl alcohol, secondary tetradecanol, pentadecanol, secondary pentadecanol, cetyl alcohol, palmityl alcohol, secondary hexadecanol, heptadecanol, secondary heptadecanol, stearyl alcohol, isostearyl alcohol, secondary octadecyl alcohol, oleyl alcohol, eicosanol, behenyl alcohol, The fatty alcohols are 2-butylhexanol, 2-butyldecanol, 2-hexyloctanol, 2-hexyldecanol, 2-hexyldodecanol, 2-octyldecanol, 2-octyldodecanol, 2-octyltetradecyl alcohol, 2-decyldodecanol, 2-decyltetradecyl alcohol, 2-decylhexadecanol, 2-dodecyltetradecyl alcohol, 2-dodecylhexadecanol and / or fatty alcohol ethers with a molar number of 1 to 30 added by polyoxyalkylene groups and mixtures thereof, or fatty alcohols of natural origin. Further preferably, octyldodecanol and / or cholesterol. Specifically, fatty alcohols of natural origin are such as cholesterol.

[0023] As a preferred embodiment of the active ingredient dissolving composition of the present invention, component (b) is selected from one or more of 1,2-octyl glycol, 1,2-hexanediol, 1,2-propylene glycol, and 1,2-pentanediol.

[0024] As a preferred embodiment of the active ingredient dissolving composition of the present invention, the ceramide in component (c) is selected from one or more of ceramide 1 (EOS), ceramide 2 (NS), ceramide 3 (NP), ceramide 4 (EOH), ceramide 5 (AS), ceramide 6 (AP), ceramide 7 (AH), ceramide 8 (NH), ceramide 9 (EOP), ceramide 10 (NDS), ceramide 11 (ADS), and ceramide 12 (EODS).

[0025] As a preferred embodiment of the active ingredient dissolving composition of the present invention, component (a) accounts for 48%-93% of the composition by weight; component (b) accounts for 5%-50% of the composition by weight; component (c) accounts for 2% of the composition by weight. Further preferably, component (a) accounts for 68%-88% of the composition by weight; component (b) accounts for 10%-30% of the composition by weight; component (c) accounts for 2% of the composition by weight.

[0026] As a preferred embodiment of the active ingredient dissolving composition of the present invention, component (a) is selected from dioctyldodecyl lauroyl glutamate and phytosterol / octyldodecyl lauroyl glutamate.

[0027] As a preferred embodiment of the active ingredient dissolving composition described in the present invention, the composition also includes at least one of the following cosmetic adjuvants and / or cleaning aids for skin, eyes, teeth and / or hair, and the cosmetic adjuvants and / or cleaning aids are selected from surfactants, rheology regulators, moisturizers, polymers, regreasing agents, sugars, inorganic powders, organic powders, silicones, pearlescent agents, pH regulators, sunscreens, preservatives, chelating agents, antimicrobial agents, antioxidants, dyes or fragrances.

[0028] In one aspect, the composition provided by the present invention is used for beauty and / or cleaning of skin, eyes, teeth and / or hair. DETAILED DESCRIPTION

[0029] While the scope of "an active ingredient dissolving composition" of the present invention is particularly pointed out and distinctly claimed in the appended claims, it is believed that the present invention will be better understood from the following description.

[0030] An active ingredient dissolving composition comprising component (a), component (b) and component (c);

[0031] Component (a) includes at least one long-chain fatty acidic amino acid ester;

[0032] Component (b) includes at least one polyol having the general formula:

[0033]

[0034] Component (c) includes at least one active substance, and component (c) is selected from one or more of glycyrrhetinic acid, stearyl glycyrrhetinate, curcumin, tetrahydrocurcumin, resveratrol, glabridin, retinol, and ceramide; wherein the general formula of ceramide is as follows:

[0035]

[0036] In a preferred embodiment, the long-chain fatty acidic amino acid ester of component (a) is preferably selected from one or more of dioctyldodecyl lauroyl glutamate and phytosterol / octyldodecyl lauroyl glutamate.

[0037] In a preferred embodiment, component (b) is preferably one or more selected from 1,2-octyl glycol, 1,2-hexanediol, 1,2-propylene glycol, and 1,2-pentanediol.

[0038] In a preferred embodiment, the ceramide in component (c) is preferably one or more selected from ceramide 1 (EOS), ceramide 2 (NS), ceramide 3 (NP), ceramide 4 (EOH), ceramide 5 (AS), ceramide 6 (AP), ceramide 7 (AH), ceramide 8 (NH), ceramide 9 (EOP), ceramide 10 (NDS), ceramide 11 (ADS), and ceramide 12 (EODS);

[0039] The specific structural formula is as follows:

[0040] Ceramide 1 (EOS)

[0041]

[0042] Ceramide 2 (NS)

[0043]

[0044] Ceramide 3 (NP)

[0045]

[0046] Ceramide 4 (EOH)

[0047]

[0048] Ceramide 5 (AS)

[0049]

[0050] Ceramide 6 (AP)

[0051]

[0052] Ceramide 7 (AH)

[0053]

[0054] Ceramide 8 (NH)

[0055]

[0056] Ceramide 9 (EOP)

[0057]

[0058] Ceramide 10 (NdS)

[0059]

[0060] Ceramide 11 (AdS)

[0061]

[0062] Ceramide 12 (EOdS)

[0063]

[0064] In a preferred embodiment, component (a) accounts for 48%-93% by weight of the composition; component (b) accounts for 5%-50% by weight of the composition; and component (c) accounts for 2% by weight of the composition. Preferably, component (a) accounts for 68%-88% by weight of the composition; component (b) accounts for 10%-30% by weight of the composition; and component (c) accounts for 2% by weight of the composition.

[0065] For researchers and technicians in this field, when preparing personal care products, in addition to the active ingredient dissolving composition, various traditional beauty adjuvants and / or cleaning adjuvants are added according to the final use without affecting the stability.

[0066] These conventional cosmetic adjuvants and / or cleaning adjuvants can be one of the following cosmetic adjuvants and / or cleaning adjuvants for skin, eyes, teeth and / or hair. The cosmetic adjuvants and / or cleaning adjuvants are selected from surfactants, rheology modifiers, moisturizers, polymers, regreasers, sugars, inorganic powders, organic powders, silicones, pearlescent agents, pH modifiers, sunscreens, active ingredients, preservatives, chelating agents, antimicrobial agents, antioxidants, dyes or fragrances, etc.

[0067] Although various conventional cosmetic or cleaning auxiliary agents are not critical to the present invention, for further understanding and illustration of the embodiments, these additives are exemplified as follows:

[0068] Examples of surfactants include fatty alcohol ethers, alkyl polyoxyethylene ether sulfates, and alkyl glycosides; examples of rheology modifiers include hydrophobically modified nonionic polyols, cellulose derivatives, and the like;

[0069] Examples of moisturizers include sodium chondroitin sulfate, sodium hyaluronate, sodium adenosine phosphate, sodium lactate, pyrrolidone carboxylate, etc.;

[0070] Examples of polymers include: polyvinyl pyrrolidone, etc.;

[0071] Examples of refining agents include: animal and plant fat derivatives, fatty acid esters, etc.;

[0072] Examples of sugars are: maltose, glucose, fructose, etc.;

[0073] Examples of inorganic powders include: modified or unmodified silica, bentonite, diatomaceous earth, etc.;

[0074] Examples of organic powders include: modified starch, lauroyl lysine, etc.;

[0075] Examples of siloxanes include dimethylsiloxane, etc.

[0076] Examples of pearlescent agents include: ethylene glycol monoesters, ethylene glycol diesters, etc.;

[0077] Examples of pH adjusters include citric acid, fruit acid, potassium hydroxide, sodium hydroxide, triethanolamine, etc.

[0078] Examples of sunscreen agents include: styrene / acrylate copolymers, etc.;

[0079] Examples of preservatives are: phenoxyethanol, methylparaben, etc.;

[0080] Examples of chelating agents include: disodium ethylenediaminetetraacetic acid, etc.;

[0081] Examples of antimicrobial agents include zinc pyrithione, chloroxylenol, etc.

[0082] Examples of antioxidants include di-tert-butyl-p-cresol and the like.

[0083] Detailed comments on these traditional cosmetic or cleaning adjuvants can be found in Sagarin's Cosmetics, Science and Technology. The variety and quantity of various traditional cosmetic or cleaning adjuvants that can be used in cleaning compositions are too numerous to list one by one. As long as they do not affect the stability of the active ingredient dissolution composition, they can be added.

[0084] Example

[0085] Below, use embodiment to further describe and illustrate specific embodiments within the scope of the present invention.These embodiments are merely illustrative, and are not intended to limit the scope of the present invention.Because scientific research and technical personnel in this field know, can carry out various changes under the condition that does not deviate from the spirit and scope of the present invention.

[0086] Unless otherwise indicated, components are referred to by their chemical name or by their CTFA name as is familiar in the art.

[0087] Example 1

[0088]

[0089]

[0090] Example 1 Process: Based on parts by mass, heat phytosterol / octyldodecyl lauroyl glutamate or dioctyldodecyl lauroyl glutamate and the active ingredients in the table to 80°C, stir to dissolve, and then cool to room temperature.

[0091] From Example 1, it can be observed that components of the above substance precipitate after being left standing at 4°C and -18°C for 24 hours.

[0092] Conclusion: Without the addition of component (b), the active component (c) alone is unstable.

[0093] Example 2

[0094]

[0095]

[0096] Example 2 Process: Heat 1,2-hexanediol, 1,2-pentanediol and the active ingredients in the table to 80°C, stir to dissolve, and then cool to room temperature.

[0097] From Example 2, it can be observed that the above materials precipitate after standing for 24 hours at 4°C and 18°C, and there is a precipitate after returning to room temperature.

[0098] Conclusion: Without the addition of component (a), the combination of component (b) and component (c) is still unstable.

[0099] Example 3

[0100]

[0101]

[0102] Example 3 Process: Mix the components in proportion, heat to 85℃~90℃ and stir until the solution is transparent, then stir and cool to room temperature.

[0103] In Example 3, it was observed that the above components were clear and transparent at room temperature and 4 degrees Celsius, the solution solidified at minus 18 degrees Celsius, and returned to clarity and transparency at room temperature.

[0104] Conclusion: Due to the simultaneous addition of component (a) and component (b), the dissolution of the active ingredient dissolving composition of component (a), component (b) and component (c) is stable.

[0105] Example 4

[0106] Ceramide Essence Oil

[0107] Raw material name Percentage W / W Caprylic / capric triglyceride 90 Add component 1 in Example 3 10 Stability: 1 month at room temperature Stablize Stability 4℃ 1 month Stablize Stability -18℃ 1 month Stablize

[0108] Example 4 Process: Mix the components in proportion at room temperature.

[0109] The ceramide essence oil in Example 4 remains transparent at room temperature and 4°C, solidifies at minus 18°C, and forms a transparent solution again after returning to room temperature.

[0110] Example 5

[0111] Licorice Whitening Essence Oil:

[0112]

[0113]

[0114] Example 5 Process: Mix the components in proportion at room temperature.

[0115] In Example 5, the glabridin whitening essential oil remained transparent at room temperature, 48°C, 4°C and minus 18°C.

[0116] Example 6

[0117] Soothing Moisturizing Lotion: The formula is as follows

[0118]

[0119]

[0120] Formula process of soothing moisturizing lotion: mix the raw materials isononyl isononanoate, ethylhexyl palmitate, squalane, formula 5, and potassium cetyl phosphate to form an oil phase and heat to 80℃~85℃, mix the raw materials glycerin, 1,3-butylene glycol and water to form an aqueous phase and heat to 80℃~85℃, stir homogenously at a homogenizing speed of 3000 rpm, then add the raw materials sodium acrylate / sodium acryloyldimethyl taurate copolymer / isohexadecane / polysorbate-80, stir and cool to 50℃, then add the preservatives phenoxyethanol and ethylhexylglycerin.

[0121] Although the embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are exemplary and are not to be construed as limitations on the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention shall be included in the scope of protection of the present invention.

Claims

1. An active ingredient dissolving composition, characterized in that: comprising component (a), component (b) and component (c); Component (a) includes at least one long-chain fatty acidic amino acid ester; Component (b) includes at least one polyol having the general formula: Component (c) includes at least one active ingredient, and component (c) is selected from glycyrrhetinic acid, stearyl glycyrrhetinate, ginger One or more of curcumin, tetrahydrocurcumin, resveratrol, glabridin, retinol, and ceramide; wherein the general formula of ceramide is as follows:

2. The composition according to claim 1, characterized in that Long-chain fatty acid amino acid esters have the following structural characteristics: Ⅰ) The number of amino groups in the acidic amino acid part of its structure is less than the number of carboxyl groups, and the carbon chain of the acidic amino acid The number of carbon atoms is 3 to 8, and the acidic amino acids include their D-type, L-type and DL-type optical isomers; [i.e., the acidic amino acids with 3 to 8 carbon atoms having 1 amino group and 2 carboxyl groups in the amino acid structure, including their D-type, L-type and DL-type optical isomers;] Ⅱ) The carbon number of the long-chain fatty acyl part in its structure is 8 to 22, and the long-chain fatty acyl is straight chain or branched Chain, the acyl group of long-chain fatty acyl comes from saturated or unsaturated fatty acids; III) The ester group in its structure is an amino acid including two carboxyl groups, and a saturated or unsaturated, straight-chain or branched fatty alcohol having 8 to 28 carbon atoms and / or a fatty alcohol or fatty alcohol ether formed by a monoester, diester or a mixture of monoester and diester formed by a fatty alcohol ether having 1 to 30 moles to which a polyoxyalkylene group is added, wherein the fatty alcohol and / or fatty alcohol ether of the diester is the same or different.

3. The composition according to claim 1, characterized in that Component (b) is selected from 1,2-octyl glycol, 1,2 One or more of hexanediol, 1,2-propylene glycol, and 1,2-pentanediol.

4. The composition according to claim 1, characterized in that The ceramide in component (c) is selected from ceramide 1 (EOS), ceramide 2 (NS), ceramide 3 (NP), ceramide 4 (EOH), ceramide 5 (AS), ceramide 6 (AP), ceramide 7 (AH), ceramide 8 (NH), ceramide 9 (EOP), ceramide 10 (NDS), ceramide 11 (ADS), ceramide 12 (EODS) kind or multiple.

5. The composition according to claim 1, characterized in that The weight ratio of component (a) to the composition is 48%-93%; the weight ratio of component (b) to the composition is 5%-50%; and the weight ratio of component (c) to the composition is 2%.

6. The composition according to claim 2, characterized in that Component (a) is selected from dioctyldodecyl lauroyl glutamate and phytosterol / octyldodecyl lauroyl glutamate.

7. The composition according to claim 5, characterized in that Component (a) accounts for 68% by weight of the composition. 88%; component (b) accounts for 10%-30% by weight of the composition; component (c) accounts for 2% by weight of the composition.

8. The composition according to any one of claims 1 to 7, characterized in that The composition further comprises at least one of the following cosmetic adjuncts and / or cleaning adjuncts for skin, eyes, teeth and / or hair, wherein the cosmetic adjuncts and / or cleaning adjuncts are selected from surfactants, rheology modifiers, moisturizers, polymers, regreasers, sugars, inorganic powders, organic powders, silicones, pearlescent agents, pH modifiers, sunscreens, preservatives, chelating agents, antimicrobial agents, antioxidants, dyes or fragrances.

9. A composition according to any one of claims 1 to 8 for use in beauty care and / or cleaning of skin, eyes, teeth and / or hair.

Images