A high-content shea butter repairing composition for skin care, and its preparation method and application

Abstract

The present application relates to the field of cosmetic technology, and specifically discloses a high-content shea butter repair composition for skin care and its preparation method and application. The high-content shea butter repair composition for skin care provided by the present application can repair and strengthen the four major barrier functions of the skin, resist the invasion and attack of harmful factors such as external physical, chemical, and biological factors, and protect the body from damage. The composition can also increase the moisture content of the skin, reduce the stimulation of external substances to the skin, and allow the skin to be in the best healthy state at any time.

Description

Technical Field

[0001] The present application relates to the technical field of cosmetics, and in particular to a high-content shea butter repairing composition for skin care, and a preparation method and application thereof. Background Art

[0002] Human skin refers to the tissue covering the human body, directly in contact with the external environment. It performs functions such as protection, sensation, secretion, excretion, and respiration. The skin is composed of the epidermis and dermis, which are tightly integrated. The epidermis is composed of stratified squamous epithelium, which, from shallow to deep, consists of the stratum corneum, stratum lucidum, stratum granulosum, and stratum germinum. The stratum corneum is composed of multiple layers of cornified epithelial cells (without nuclei and organelles and with thicker cell membranes). It is lifeless and impermeable, but it prevents the outflow of tissue fluid, resists friction, and protects against infection. Cells in the stratum germinum continuously proliferate and gradually migrate outward to replenish the stratum corneum that is constantly shed. The stratum germinum contains a type of melanocyte that produces melanin. Skin color is related to the amount of melanin. The dermis is composed of dense connective tissue, which, from shallow to deep, consists of the papillary stratum and reticular stratum, with no clear boundary between the two layers. The dermis is approximately 0.07 to 0.12 mm thick; it is thicker on the palms and soles, about 1.4 mm, and thinner around the eyelids and eardrum, about 0.05 mm. The papillary layer is connected to the germinal layer of the epidermis and contains a rich supply of capillaries, lymphatic vessels, nerve endings, and tactile receptors such as corpuscles. The reticular layer is connected to the subcutaneous tissue and contains a rich network of collagen, elastic fibers, and reticular fibers, which interweave to form a network that gives the skin its elasticity and resilience. The reticular layer also contains a rich supply of blood vessels, lymphatic vessels, and nerve endings.

[0003] The skin is also the body's nervous, endocrine, and immune organs. A healthy "skin barrier" protects the skin while also maintaining homeostasis in the nervous, endocrine, and immune systems. It is essential for human health and forms the basis for healthy, beautiful skin and a healthy body. The skin barrier is a vital structure that protects the human body. It defends against microbial antigens and damage from ultraviolet rays. Internally, it locks in moisture, preventing it from escaping the epidermis and maintaining the skin's hydration and lipid levels. A damaged skin barrier can easily lead to dryness, scaling, and even sensitivity. It can also trigger inflammatory skin diseases such as atopic dermatitis, psoriasis, and chronic actinic dermatitis. Therefore, protecting the skin's barrier is crucial.

[0004] Epidermal barrier function generally refers to the ability of the epidermis to prevent excessive water from entering and leaving the body. Growing evidence suggests that reduced epidermal permeability barrier function can lead to an increase in the production of inflammatory cytokines in the epidermis and dermis, Langerhans cells, and mast cells in the dermis. This increases the risk of dermatitis following skin irritation. Furthermore, impaired epidermal permeability barrier function promotes bacterial colonization of the skin, and reduced epidermal permeability barrier function is associated with the development and progression of at least atopic dermatitis and psoriasis. Using safe skincare products that comprehensively improve epidermal function can help prevent and treat certain skin and systemic diseases, as well as related mental disorders.

[0005] Currently, there are many factors that cause skin barrier damage. In addition to disease factors, environmental factors cannot be ignored. Studies have shown that unhealthy lifestyles and environmental exposures, such as long-term contact with irritants (such as detergents), working in humid environments, and active or passive smoking, can cause abnormalities in skin lipid metabolism, ultimately leading to impaired skin barrier function.

[0006] The skin barrier includes a microbial barrier (referring to the various microorganisms present on the skin surface forming a microecosystem to resist the invasion of pathogens and enhance skin immunity), a chemical barrier (the pH value of the skin surface is about 4-6, forming an "acidic barrier", mainly composed of acidic substances such as fatty acids and lactic acid, hydrolases and antimicrobial peptides), a physical barrier (keratinized cells and intercellular lipids in the stratum corneum form a brick wall structure, and cells adhere together through cell junctions to form a "protective wall") and an immune barrier (Langerhans cells in the epidermis act as "guards" and "sentinels", removing foreign matter and awakening the immune system of the skin). Damage to the skin barrier can induce / aggravate skin problems, such as skin sensitivity symptoms and even skin diseases; and skin diseases, such as skin inflammation and acne, can in turn lead to damage to the skin barrier.

[0007] Sensitive skin is a problematic skin. The characteristics of sensitive skin are: the skin looks thinner, is prone to allergies, and has obvious red blood streaks on the face (dilated capillaries); the skin is prone to redness and fever due to temperature changes, such as excessive cold or excessive heat; it is easily irritated by environmental factors, seasonal changes and facial care products. It is usually attributed to genetic factors, but more often it is due to the use of hormone-based cosmetics, which leads to sensitive skin and may be accompanied by skin sensitivity throughout the body.

[0008] Besides genetic factors, the root cause of sensitive skin is damaged skin cells, which reduces the skin's immune system. Thinning of the stratum corneum leads to insufficient moisture, ultimately weakening the skin's barrier function and making it unable to resist external stimuli. Consequently, the skin's nerve fibers, constantly exposed to external stimuli, become overly excited, leading to redness, fever, itching, stinging, rashes, and other discomforts.

[0009] At present, for sensitive skin, most skin care products on the market are mainly based on oil moisturizing and hydrating, while using some soothing ingredients, which can objectively relieve skin dryness and inflammation. However, this combination is only a temporary solution and cannot fundamentally solve the problem of sensitive skin. Summary of the Invention

[0010] The present application aims to overcome the shortcomings of the aforementioned prior art by providing a high-content shea butter repair composition for skin care, as well as its preparation method and application. This composition addresses the problems of damaged skin cells, which can lead to decreased skin immunity, thinning of the stratum corneum, and insufficient skin moisturization. This ultimately weakens the skin's barrier function, making it unable to resist external stimuli and susceptible to redness, fever, itching, stinging, rashes, and other issues. The high-content shea butter repair composition provided in this application fundamentally repairs the skin's barrier (microbial, chemical, physical, and immune barriers), maintaining homeostasis of the neuro-endocrine-immune systems while protecting the skin, ultimately contributing to healthy skin.

[0011] To achieve the above objectives, the technical solutions adopted in this application are:

[0012] The present application provides a high-content shea butter repairing composition for skin care, the composition comprising the following components in percentage by mass:

[0013] Avocado butter 10-30%, avocado oil 0.01-6.99%, avocado butter unsaponifiable matter 0.001-1%, ceramide 0.001-1%, phytosteryl oleate 0.01-3%, lactobacillus fermentation product 0.001-1%, amino acids 0.003-7% and bisabolol 0.01-1%.

[0014] The present application adopts avocado butter, avocado oil, avocado butter unsaponifiable matter, ceramide, phytosterol oleate, lactobacillus fermentation product, amino acid and bisabolol and other components to obtain the high-content shea butter repair composition of the present application. The composition does not add artificially synthesized pigments and does not contain 26 kinds of fragrance allergen ingredients. The composition can maintain skin moisture, repair the stratum corneum, and maintain the skin barrier function. The brick wall structure of the skin is attached with a sebum film on the surface, which together form a natural protective barrier for the human body, effectively reducing the irritation and impact of the product on sensitive skin. It is gentle and non-irritating, maintains skin moisture, prevents moisture evaporation, and resists external irritation and damage, which is the function of the skin barrier. It effectively repairs sensitive skin and inflamed skin and is suitable for people with all skin types.

[0015] In addition, the composition of the present application can help repair the four major skin barriers (microbial barrier, chemical barrier, physical barrier and immune barrier) in an all-round way, repairing the skin barrier from the root, protecting the skin while maintaining the homeostasis of the neuro-endocrine-immune systems, and achieving human skin health.

[0016] Among them, avocado tree fat and avocado tree oil are called shea butter. The composition contains more than 10% natural shea butter. Shea butter is closest to the various indicators of human sebum secretion. Shea butter is rich in unsaponifiable substances with anti-inflammatory and repairing properties, and has moisturizing fatty acid triglycerides. It has a deep moisturizing and repairing effect on the skin, making the skin absorb the effective ingredients more completely. It can not only prevent dryness and cracking, but also further restore and maintain the natural elasticity of the skin. It has a deep moisturizing effect, can promote epidermal cell regeneration, and provide nutrition to the skin. It can also form a protective barrier on the skin to protect the skin from external irritation and damage.

[0017] The composition of the present application contains lactobacillus fermentation products, which are inactivated lactobacilli that retain the complete cell wall structure of the bacteria, regulate the microecological flora, can stimulate the skin to produce antimicrobial peptides, enhance the skin's ability to resist external irritants, and enhance the skin's resistance to pathogens.

[0018] This application uses a compound of liquid shea butter, plant sterol esters and ceramides to form a bionic sebum film, which fills the "mortar" inside the classic skin brick wall structure of the stratum corneum, plays a physical barrier repair role, thereby enhancing the keratinized cells and intercellular lipids in the stratum corneum to form a brick wall structure. The cells adhere together through cell connections to form a solid "protective wall", which effectively blocks the invasion of harmful external substances and prevents excessive loss of water and nutrients in the body.

[0019] The composition of the present application contains amino acids, which are one of the natural moisturizing factors in the skin and are also the basic components of protein. Moisturizers made with amino acids have excellent sustained moisturizing ability, helping to enhance the skin's water retention capacity, prevent excessive water loss, and maintain a healthy chemical skin barrier function. Using the above concentration of amino acids, the repair composition can achieve a good moisturizing effect without excessively high formulation costs, which is more conducive to the commercialization and marketability of the product.

[0020] The ingredient bisabolol inhibits inflammation internally, enhances the skin's self-immunity ability externally, soothes the skin, reduces inflammatory response, repairs the skin's immune system, and promotes skin repair and healing; the above concentration of bisabolol can show excellent anti-inflammatory and soothing effects.

[0021] The bisabolol and unsaponifiable matter of avocado tree butter in the composition of the present application inhibit inflammation internally, enhance the self-immunity ability externally, soothe the skin, reduce inflammatory response, repair the skin's immune system, and promote skin repair and healing.

[0022] As a preferred embodiment of the high-content shea butter repairing composition for skin care described in the present application, the amino acids include 0.001-4% glycine, 0.001-2% serine and 0.001-1% alanine.

[0023] Amino acid is one of the natural moisturizing factors in the skin and is also the basic component of protein. It contains natural moisturizing factor amino acid components glycine, serine and alanine to help enhance the skin's water retention, prevent the skin from losing water too quickly, and maintain a healthy chemical skin barrier function.

[0024] Filaggrin plays a crucial role in the skin's chemical barrier, strengthening its barrier function and maintaining moisture retention. Within the stratum granulosum, inactive / insoluble filaggrin precursors are formed during the late stages of keratinocyte differentiation. Proteases, such as kallikrein, break them down into free, filamentous filaggrin monomers. Filaggrin monomers function within the stratum corneum by directly binding to keratin, polymerizing into keratin bundles and forming the cytoskeleton, the supporting structure of the stratum corneum. They are subsequently degraded into free amino acids and derivatives, such as urocanic acid (UCA) and pyrrolidone carboxylic acid (PCA), which constitute the natural moisturizing factor (NMF).

[0025] As a preferred embodiment of the high-content shea butter repairing composition for skin care described in the present application, the composition includes the following components in percentage by mass:

[0026] Avocado butter 10-20%, avocado oil 1-6%, avocado butter unsaponifiable matter 0.1-0.8%, ceramide 0.01-0.5%, phytosteryl oleate 0.1-2%, lactobacillus fermentation product 0.05-0.8%, glycine 0.01-2%, serine 0.01-1%, alanine 0.01-0.8% and bisabolol 0.1-0.8%.

[0027] The present application adopts the components in the above-mentioned preferred range, which can better repair and strengthen the four major barrier functions of the skin, resist the invasion of external physical, chemical, biological and other harmful factors, and protect the body from damage.

[0028] This application uses the above-mentioned shea butter ingredient in the above-mentioned mass percentage, which is mild and non-irritating, has good breathability, and can be quickly absorbed by the skin. It not only has deep moisturizing and high-efficiency moisturizing effects, but also can effectively repair various wounds, dryness, peeling, whitening and sensitivity caused by sunburn and frostbite on the skin; at the same time, the unsaponifiable matter of avocado tree fat also has anti-inflammatory and antioxidant effects, inhibits skin inflammation, enhances self-immunity ability, soothes the skin, promotes skin healing, and anti-aging.

[0029] Preferably, the composition comprises the following components in percentage by mass:

[0030] Avocado Butter 15%, Avocado Oil 5%, Avocado Butter Unsaponifiables 0.5%, Ceramide 0.2%, Phytosteryl Oleate 0.5%, Lactobacillus Ferment 0.5%, Glycine 0.5%, Serine 0.5%, Alanine 0.5% and Bisabolol 0.5%.

[0031] When the repair composition uses the components in the above preferred concentrations, it can better and more effectively repair the four major skin barriers, increase the skin's moisture content and strengthen the skin's barrier function, reduce the irritation of external substances to the skin, and keep the skin in the best health at all times.

[0032] Product stability experiments have shown that when the shea butter content in the composition exceeds the above concentration range, many problems may occur, such as product failure, poor product absorption, coarse paste, and abnormal odor. When the concentration of phytosteryl oleate in the composition exceeds the above concentration range, it is not conducive to the formation of stable biomimetic sebum, and problems such as product discoloration and abnormal odor may occur.

[0033] Since ceramide has very poor solubility, it is not only insoluble in water, but also soluble in only a very small amount of oil. If it is not well soluble, it is difficult to play a role in skin care. When the amount added to the formula exceeds the above concentration range, it is difficult to dissolve in the formula, resulting in precipitation during the placement process after emulsification.

[0034] The present application also provides a method for preparing the above-mentioned high-content shea butter repairing composition for skin care, comprising the following steps:

[0035] A high-content shea butter repairing composition is obtained by mixing shea butter, shea oil, shea butter unsaponifiable matter, ceramide, phytosterol oleate, lactobacillus fermentation product, amino acid and bisabolol.

[0036] The present application also provides the use of the above-mentioned high-content shea butter repair composition for skin care in the preparation of skin care products.

[0037] As a preferred embodiment of the application described in this application, the skin care product includes at least one of cream, lotion, essence and gel.

[0038] The present application also provides a skin care product, which includes the high-content shea butter repairing composition for skin care.

[0039] The skin care product provided by the present application, which contains a high-content shea butter repair composition, has a refreshing feel and can be quickly absorbed by the skin. It not only deeply moisturizes and effectively moisturizes the skin, but also repairs skin problems such as dryness and peeling. At the same time, it contains a variety of nutrients and antioxidants required by the skin, improves the epidermal barrier capacity, effectively resists skin aging problems, effectively alleviates skin problems under environmental pressure, improves local microcirculation of the lips, restores normal metabolism, and makes the skin fuller, smoother, more defined, hydrated and rosy.

[0040] As a preferred embodiment of the skin care product described in this application, the addition amount of the high-content shea butter repairing composition for skin care is 10~35%.

[0041] As a preferred embodiment of the skin care product described in the present application, the skin care product includes at least one of a cream, a body lotion, an emulsion, an essence and a gel.

[0042] Preferably, the cream comprises a hand cream or a face cream.

[0043] The formulation of the skin care product described in this application is not limited to product specifications and forms, for example, but not limited to, it can be made into product dosage forms such as cream, body lotion, lotion, essence, gel, etc.

[0044] This application is based on a high-content shea butter repair composition, and by adding other auxiliary materials, a skin care product with four major skin barrier functions of moisturizing, anti-inflammatory and skin repair is prepared, including hand cream, face cream, body milk, lotion and other skin care dosage forms.

[0045] As a preferred embodiment of the skin care product described in the present application, the skin care product also includes at least one of 0.5-10% moisturizer, 0.1-0.5% thickener, 0.01-0.4% pH adjuster, 1-10% oil, 0.5-3% surfactant, 0.5-3% fatty alcohol, 0.1-1.0% preservative, and 0.01-0.1% antioxidant.

[0046] As a preferred embodiment of the skin care product described herein, the moisturizer includes a polyol (e.g., concentrated glycerin);

[0047] The thickener comprises at least one of xanthan gum, cellulose gum, carbomer and sodium polyacrylate;

[0048] The surfactant includes a nonionic or amphoteric surfactant; the surfactant includes at least one of glyceryl stearate / PEG-100 stearate and polysorbate-60;

[0049] The oily agent includes triethylhexanoin and / or dimethicone.

[0050] The preservative comprises at least one of phenoxyethanol, chlorphenesin, 1,2-hexanediol and chlorphenesin;

[0051] The antioxidant includes at least one of butylated hydroxyanisole, butylated hydroxytoluene, tert-butylhydroquinone and tocopherol.

[0052] The present application also provides a method for preparing the above-mentioned skin care product, comprising the following steps:

[0053] S1. Mix purified water, thickener, and humectant to obtain an aqueous phase;

[0054] S2. Mixing a surfactant, an oil, avocado butter, avocado oil, avocado butter unsaponifiable matter, phytosteryl oleate, ceramide, bisabolol, and an antioxidant with heating and stirring to obtain an oil phase;

[0055] S3. Add the oil phase in step S2 to the water phase in step S1 and homogenize and emulsify, then add a pH regulator, a lactobacillus fermentation product, amino acids and a preservative and mix and stir evenly to obtain a skin care product.

[0056] As a preferred embodiment of the method for preparing the skin care product of the present application, in step S2, the heating temperature is 75-85°C;

[0057] In step S3, the homogenization time is 10 to 15 minutes.

[0058] Compared with the prior art, this application has the following beneficial effects:

[0059] The present application provides a high-content shea butter repair composition for skin care, its preparation method, and application. The present application uses a shea butter, avocado oil, avocado butter unsaponifiable matter, ceramide, phytosterol oleate, lactobacillus fermentation product, amino acids, and bisabolol to repair and strengthen the skin's four major barrier functions, resisting the invasion of external physical, chemical, and biological harmful factors, and protecting the body from damage. The composition can also increase skin moisture content, reduce skin irritation by external substances, and keep the skin in optimal health at all times.

[0060] Among them, this application uses a compound of liquid shea butter, plant sterol esters and ceramides to form a bionic sebum film, which fills the "mortar" inside the classic skin brick wall structure of the stratum corneum, plays a physical barrier repair role, thereby enhancing the keratinized cells and intercellular lipids in the stratum corneum to form a brick wall structure. The cells adhere together through cell connections to form a solid "protective wall", which effectively blocks the invasion of harmful substances from the outside world and prevents excessive loss of water and nutrients in the body.

[0061] The composition of the present application contains lactobacillus fermentation products, which are inactivated lactobacilli that retain the complete cell wall structure of the bacteria, regulate the microecological flora, can stimulate the skin to produce antimicrobial peptides, enhance the skin's ability to resist external irritants, and enhance the skin's resistance to pathogens.

[0062] The bisabolol and unsaponifiable matter of avocado tree butter in the composition of the present application inhibit inflammation internally, enhance the self-immunity ability externally, soothe the skin, reduce inflammatory response, repair the skin's immune system, and promote skin repair and healing. BRIEF DESCRIPTION OF THE DRAWINGS

[0063] Figure 1 This is a graph showing the effects of different repair compositions on skin moisturizing properties in Experimental Example 1;

[0064] Figure 2 Figure 1 shows the skin barrier enhancement results of a cream formulation containing a repair composition comprising ceramide NPs and phytosterol oleate (Example 10) and a cream formulation not containing ceramide NPs and phytosterol oleate (Comparative Example 19) in Experimental Example 3;

[0065] Figure 3 The results of the cream formula containing the repair composition component of the lactobacillus fermentation product (Example 10) and the cream formula without the lactobacillus fermentation product (Comparative Example 20) in Experimental Example 3 on skin inflammation are shown in FIG.

[0066] Figure 4 This is a graph showing the effects of the creams prepared in Example 10 and Comparative Example 21 on skin moisturizing and barrier function in Experimental Example 3;

[0067] Figure 5 This is a graph showing the effects of the creams of Example 10 and Comparative Example 22 on skin repair in Experimental Example 3;

[0068] Figure 6 This is a graph showing the effect of different concentrations of the repair composition containing the fermentation product of lactobacillus (Example 1, Comparative Example 15) on the relative abundance of Staphylococcus on the skin surface in Experimental Example 3;

[0069] Figure 7Graph showing the results of a redness fading test using repair compositions with different concentrations of bisabolol in Experimental Example 3 (Example 1, Example 5, Comparative Example 16);

[0070] Figure 8 This is a graph showing the skin moisturizing test results of the repair compositions of Example 5 and Comparative Example 17 in Experimental Example 3;

[0071] Figure 9 This is a graph showing the skin smoothness results of the repair compositions of Example 5 and Comparative Example 17 in Test Example 3;

[0072] Figure 10 This is a graph showing the results of the inhibition of inflammatory enzymes by the repair compositions of Example 5 and Comparative Example 17 in Experimental Example 3;

[0073] Figure 11 This is a graph showing the moisturizing effect of the facial cream product of Example 10 and the facial cream of the blank control group (not containing the repairing composition) for 48 hours in Experimental Example 3;

[0074] Figure 12 The graph shows the length of the intercellular lipid film after SDS damage treatment. DETAILED DESCRIPTION

[0075] In order to better illustrate the purpose, technical solutions and advantages of this application, this application will be further described below with reference to the accompanying drawings and specific embodiments.

[0076] In the following examples and comparative examples, the experimental methods used are conventional methods unless otherwise specified, and the materials, reagents, etc. used are all commercially available unless otherwise specified, and the components and raw materials used in each parallel experiment are all of the same kind.

[0077] The component information of the high-content shea butter repair composition provided in the following examples and comparative examples is shown in Table 1 (the following components can all be purchased from the chemical or pharmaceutical market).

[0078] Table 1

[0079]

[0080] Examples 1 to 5: A high-content shea butter repair composition for skin care

[0081] Examples 1 to 5 provide a high-content shea butter repairing composition for skin care, the formula of which is shown in Table 1 (mass percentage).

[0082] The preparation method of the high-content shea butter repairing composition for skin care comprises the following steps:

[0083] A high-content shea butter repairing composition is obtained by mixing shea butter, shea oil, shea butter unsaponifiable matter, ceramide, phytosterol oleate, lactobacillus fermentation product, amino acid and bisabolol.

[0084] Table 1

[0085]

[0086] Comparative Examples 1 to 17

[0087] Comparative Examples 1 to 17 provide a high-content shea butter repairing composition for skin care, the formula of which is shown in Table 2 (mass percentage).

[0088] The preparation methods of the high-content shea butter repair compositions provided in Comparative Examples 1 to 17 are similar to those of the repair compositions of Examples 1 to 5.

[0089] Table 2

[0090]

[0091] Examples 6-10: A moisturizing and repairing facial cream and its preparation method

[0092] The formulas of the moisturizing and repairing facial creams provided in Examples 6 to 10 are shown in Table 3.

[0093] The moisturizing and repairing facial creams provided in Examples 6 to 10 respectively use the repairing compositions prepared in Examples 1 to 5.

[0094] The preparation method of the moisturizing and repairing facial cream provided in this embodiment comprises the following steps:

[0095] 1. Instrument disinfection: First, clean the instruments including the reactor with 80-100°C sterile water, then rinse with 75% disinfectant alcohol and blow dry with cold air;

[0096] 2. Prepare the aqueous phase: Add the formulated amount of purified water, disodium EDTA, carbomer, and concentrated glycerin to the reactor, start stirring, and ensure that the mixture is evenly dispersed without particles. Heat to 75-85°C and keep warm.

[0097] 3. Oil phase preparation: Add the formulated amount of surfactant (glyceryl stearate / PEG-100 stearate and polysorbate 60, mass ratio of 1:1), oil (polydimethylsiloxane), cetyl alcohol, shea butter, phytosteryl oleate, ceramide, bisabolol and antioxidant (butylated hydroxytoluene) in the repair composition to the side reactor, start heating and stirring, heat to 75-85℃, and ensure that it is completely dissolved into a transparent liquid;

[0098] 4. Adding materials: Start stirring and keeping the reactor warm, slowly pump the oil phase from the secondary reactor into the reactor, and start high-speed homogenization and emulsification. After the oil phase is completely added, keep warm and homogenize for 10-15 minutes to ensure complete and uniform emulsification. Stop homogenization, maintain stirring and start cooling to 55°C, add pH adjuster, continue stirring and start cooling to 40°C, add other ingredients of the repair composition (Lactobacillus fermentation product, arginine, serine and alanine), preservatives (phenoxyethanol / ethylhexylglycerin, ratio of 9:1) and essence, and stir to ensure uniform mixing;

[0099] 5. Cool down to room temperature and the mixing is completed;

[0100] 6. Quality inspection and filling: After cooling to room temperature, check that it is qualified and then fill it to obtain the moisturizing repairing cream.

[0101] Table 3

[0102]

[0103] Comparative Examples 18~34

[0104] Compared with Example 10, Comparative Examples 18 to 34 provide a moisturizing repairing cream, the difference being that the repairing composition is different, and the remaining contents and preparation methods are the same as those in Example 6.

[0105] Compared with Example 6, Comparative Examples 18 to 34 respectively used the repair compositions of Comparative Examples 1 to 17.

[0106] Examples 11-15: A moisturizing and repairing hand cream and its preparation method

[0107] The formulas of the moisturizing and repairing hand creams provided in Examples 11 to 15 are shown in Table 4.

[0108] The moisturizing and repairing hand creams provided in Examples 11 to 15 respectively use the repairing compositions prepared in Examples 1 to 5.

[0109] The preparation method of the moisturizing and repairing hand cream provided in this embodiment comprises the following steps:

[0110] 1. Instrument disinfection: First, clean the instruments including the reactor with 80-100°C sterile water, then rinse with 75% disinfectant alcohol and blow dry with cold air;

[0111] 2. Prepare the aqueous phase: Add the formulated amount of purified water, disodium EDTA, thickener carbomer, and concentrated glycerin to the reactor, start stirring, and ensure that the mixture is evenly dispersed without particles. Heat to 75-85°C and keep warm.

[0112] 3. Oil phase preparation: Add the formulated amount of surfactant (glyceryl stearate / PEG-100 stearate and polysorbate 60, mass ratio of 1:1), oil (glyceryl triethylhexanoate and polydimethylsiloxane), higher fatty alcohol (cetyl alcohol), shea butter, phytosteryl oleate, ceramide, bisabolol and antioxidant (butylated hydroxytoluene) in the repair composition to the side reactor, start heating and stirring, heat to 75-85℃, and ensure that they are completely dissolved into a transparent liquid;

[0113] 4. Adding materials: Start stirring and keeping the reactor warm, slowly pump the oil phase from the secondary reactor into the reactor, and start high-speed homogenization and emulsification. After the oil phase is completely added, keep warm and homogenize for 10-15 minutes to ensure complete and uniform emulsification. Stop homogenization, maintain stirring and start cooling to 55°C, add pH adjuster (triethanolamine), continue stirring and start cooling to 40°C, add other ingredients of the repair composition (Lactobacillus fermentation product, arginine, serine and alanine), preservatives (phenoxyethanol / ethylhexylglycerin, ratio of 9:1) and essence, and stir to ensure uniform mixing;

[0114] 5. Cool down to room temperature and the mixing is completed;

[0115] 6. Quality inspection and filling: After cooling to room temperature, check that it is qualified and then fill it to obtain moisturizing and repairing hand cream.

[0116] Table 4

[0117]

[0118] Comparative Examples 35-43

[0119] Compared with Example 11, Comparative Examples 35 to 43 provide a moisturizing repairing hand cream, the difference being that the repairing composition is different, and the remaining contents and preparation methods are the same as those of Example 7.

[0120] Compared with Example 11, Comparative Examples 35 to 43 respectively used the repair compositions of Comparative Examples 6 to 14.

[0121] Examples 16-20: A moisturizing and repairing body lotion and its preparation method

[0122] The formulas of the moisturizing and repairing body lotions provided in Examples 16 to 20 are shown in Table 5.

[0123] The moisturizing and repairing body lotions provided in Examples 16 to 20 respectively use the repairing compositions prepared in Examples 1 to 5.

[0124] The preparation method of the moisturizing and repairing body lotion provided in the embodiment comprises the following steps:

[0125] 1. Instrument disinfection: First, clean the instruments including the reactor with 80-100°C sterile water, then rinse with 75% disinfectant alcohol and blow dry with cold air;

[0126] 2. Prepare the aqueous phase: Add the formulated amount of purified water, disodium EDTA, carbomer, and concentrated glycerin to the reactor, start stirring, and stir to ensure uniform dispersion without particles. Heat to 75-85°C and keep warm.

[0127] 3. Oil phase preparation: Add the formulated amount of surfactant (glyceryl stearate / PEG-100 stearate and polysorbate 60, mass ratio of 1:1), oil (polydimethylsiloxane), shea butter, phytosteryl oleate, ceramide, bisabolol and antioxidant (butylated hydroxytoluene) in the repair composition to the side reactor, start heating and stirring, heat to 75-85℃, and ensure that they are completely dissolved into a transparent liquid;

[0128] 4. Adding materials: Start stirring and keeping the reactor warm, slowly pump the oil phase from the secondary reactor into the reactor, and start high-speed homogenization and emulsification. After the oil phase is completely added, keep warm and homogenize for 10-15 minutes to ensure complete and uniform emulsification. Stop homogenization, maintain stirring and start cooling to 55°C, add pH adjuster (triethanolamine), continue stirring and start cooling to 40°C, add the other ingredients of the repair composition (Lactobacillus fermentation product, arginine, serine and alanine, preservatives (phenoxyethanol / ethylhexylglycerin) and fragrance, and stir to ensure uniform mixing;

[0129] 5. Cool down to room temperature and the mixing is completed;

[0130] 6. Quality inspection and filling: After cooling to room temperature, check that it is qualified and then fill it to obtain the moisturizing and repairing body lotion.

[0131] Table 5

[0132]

[0133] Comparative Examples 44-52

[0134] Compared with Example 17, Comparative Examples 44 to 52 provide a moisturizing and repairing body lotion, the difference being that the repairing composition is different, and the remaining contents and preparation methods are the same as those of Example 8.

[0135] Compared with Example 17, Comparative Examples 44 to 52 respectively used the repair compositions of Comparative Examples 6 to 14.

[0136] Experimental Example 1: Effects of Different Repair Compositions on Skin Moisturization

[0137] After applying the repair compositions (Examples 1-5, Comparative Examples 1-5, and Comparative Examples 15-17) to the test areas of the subjects, transepidermal water loss and skin moisturization were measured every hour for a total of four hours. Background measurements were taken before and after alcohol cleansing. Evaluations were performed using a Courage+Khazaka MPA 5 system equipped with a Tewameter 300 and a Corneometer CM 825 probe. Data were taken when the signal stabilized, and the average of at least 20 readings was used as the measurement value. The results are shown in Table 6.

[0138] Test process:

[0139] 1. Test site: hand skin;

[0140] 2. Test time: 4 hours;

[0141] 3. Before and after using alcohol to cleanse the test product, apply an appropriate amount to the palm of your hand and gently pat the skin until it is completely absorbed;

[0142] 4. Participants: 20 women, aged 20-55 years;

[0143] 5. Testing Procedure: 1) One week prior to the test, subjects must stop using any moisturizing composition on the test area; 2) Subjects must listen to the test instructions on-site and sign an informed consent form; 3) Subjects must visit the laboratory, cleanse their faces with clean water, dry them with a non-dandruff absorbent tissue, and sit quietly in a constant temperature and humidity room for 30 minutes. No water or beverages are allowed during this time, and subjects must remain relaxed; 4) Testing: After applying the repair composition, transepidermal water loss and skin moisturization in the test area are measured every hour for a total of four hours; 5) Data are compiled and a report is issued.

[0144] As expected, the alcohol-scrubbed test area experienced an immediate increase in TEWL. Approximately two hours after application, TEWL returned to its initial value in the area treated with the shea butter repair composition. Three to four hours later, the moisture barrier was further strengthened, and TEWL decreased further.

[0145] In contrast, the repair composition without shea butter (Comparative Example 1) did not show the phenomenon of rapid recovery of transepidermal water loss as shea butter did.

[0146] The use of the repair composition containing shea butter (Example 5) can improve the moisture retention of the skin, as shown in the measurement results after 1 hour of use, and its moisturizing effect lasts for a period of 4 hours. The composition without shea butter has a less effective effect on the moisture measurement value (such as Figure 1The results of these two different tests show that the moisturizing and hydrating properties of the shea butter repair composition decreased to varying degrees when shea butter was missing.

[0147] Table 6 Moisturizing test

[0148]

[0149] Experimental Example 2: Effects of Different Repair Compositions on Skin Barrier Function

[0150] Test instrument: Vapometer transepidermal water loss measuring instrument (produced by Delfin Technologies). Read the data when the signal is stable, and take the average value of at least 20 readings as the measured value.

[0151] 1. Experimental test: Test the effects of the repair compositions of Examples 1 to 5 and Comparative Examples 1 to 5 and Comparative Examples 15 to 17 on the skin barrier function.

[0152] Test process:

[0153] 1. Test site: facial skin;

[0154] 2. Test time: 0 hours, 4 hours;

[0155] 3. Test product usage: Clean hands with water and dry with a non-chip absorbent paper towel. Apply an appropriate amount to the palm of your hand and gently pat the skin until completely absorbed.

[0156] 4. Participants: 20 women, aged 20-55 years;

[0157] 5. Testing process:

[0158] 1) One week before the test, the subject stopped using the repair composition with moisturizing effect on the test area;

[0159] 2) The subjects signed the informed consent form after listening to the trial description on site;

[0160] 3) When the subjects come to the laboratory, they must clean their faces with clean water and dry them with a lint-free absorbent paper towel. They must sit quietly in a constant temperature and humidity room for 30 minutes without drinking water or other beverages and must remain relaxed.

[0161] 4) Test: Clean the face with clean water and dry it with a dry paper towel without dandruff. Then apply the repair composition.

[0162] The skin TEWL value of the skin at this time is measured with an instrument as the comparison data of T0, and then the repair composition is applied; after 4 hours, the transepidermal water loss of the area is measured as the T4 data;

[0163] 5) Organize data and produce reports.

[0164] The results are shown in Table 7.

[0165] Table 7

[0166]

[0167] Experimental Example 3: Effects of Products Containing Different Repair Compositions on Skin

[0168] 1. This experiment also compared a cream formula containing a repair composition component of ceramide NP and phytosterol oleate (Example 10) and a cream formula without ceramide NP and phytosterol oleate (Comparative Example 19) to test their respective effects on enhancing the skin barrier.

[0169] The results showed that the use of the cream containing the repair composition of ceramide NP and phytosterol oleate for 6 days increased the epidermal thickness by more than 50% compared with the cream without the repair composition of ceramide NP and phytosterol oleate. Figure 2 shown.

[0170] 2. This experiment also compared the repair composition ingredients of a face cream formula containing a lactobacillus fermentation product (Example 10) and the repair composition ingredients of a face cream formula not containing a lactobacillus fermentation product (Comparative Example 20), and compared the effects of each on skin inflammation.

[0171] Lactobacillus fermentation products are inactivated lactobacilli that retain the complete cell wall structure of the bacteria. They can regulate the microecological flora, stimulate the skin to produce antimicrobial peptides, enhance the skin's microecological barrier function, and reduce skin inflammation.

[0172] The results showed that the skin inflammatory factor IL-8 (produced by IL-1α or Staphylococcus aureus) decreased by 45% when the cream containing the repair composition of lactobacillus fermentation products was used compared with the cream without the repair composition of lactobacillus fermentation products. Figure 3 shown.

[0173] 3. This experiment also compared the effects of the creams prepared in Example 10 and Comparative Example 21 on the skin's moisturizing and barrier functions. The repair composition containing glycine, serine, and alanine (Example 10) can stimulate the production of filaggrin and enhance the skin's moisturizing and barrier functions, such as Figure 4 shown.

[0174] 4. This experiment also compared the effects of the creams of Example 10 and Comparative Example 22 on skin repair.

[0175] Redness-removing and soothing test:

[0176] Instrument: VISIA CR (Canfield Scientific)

[0177] Samples: A1 (repairing composition cream, Example 6); A2 (repairing composition cream without bisabolol, Comparative Example 22);

[0178] Methods: Thirty subjects used two samples twice daily, using a half-face control method. Sample A1 and Sample A2 were applied to the left and right halves of the face, once in the morning and once in the evening. High-resolution frontal images were taken using VISIACR before application and at 0.5 hours, 1 hour, 3 hours, 24 hours, 3 days, and 7 days after application. Erythema was analyzed using IPP software.

[0179] The results show that the repair composition containing bisabolol can effectively reduce facial erythema and soothe sensitive skin, and the effect is significantly better than the repair composition without bisabolol. Figure 5 shown.

[0180] 5. This experiment also compared the effects of repair compositions containing different concentrations of lactobacillus fermentation products (Example 1, Comparative Example 15) on the relative abundance of Staphylococcus on the skin surface.

[0181] Lactobacillus fermentation products, by regulating the microecological flora, stimulate the skin to produce antimicrobial peptides, enhance the microecological barrier function of the skin, thereby enhancing the skin's ability to resist external irritants and enhance the skin's resistance to pathogens. However, the biological flora of human skin is relatively balanced. Only when probiotics and harmful bacteria are in a balanced state can it be beneficial to skin health. If probiotics or harmful bacteria are too strong, they will break the microecological balance of the skin, thereby causing an imbalance in the microecological barrier. Through testing, the skin care effect of the acid bacteria fermentation product concentration of 0.1~1.0% is the abundance of Staphylococcus epidermidis in the skin: the initial concentration increased by 20%. When the concentration of lactobacillus fermentation products continues to increase, the concentration of Staphylococcus epidermidis in the skin is reduced to the initial state, which shows that the higher the concentration of this substance is, the more beneficial it is to the skin. Figure 6 shown.

[0182] 6. This experiment also compared the redness fading test of repair compositions using different concentrations of bisabolol (Example 1, Example 5, Comparative Example 16).

[0183] The test results clearly show that 0.5% bisabolol has the best redness-reducing effect, and 1.0% bisabolol has a redness-reducing effect of 68%. However, when the concentration of bisabolol exceeds 1.0%, the redness-reducing effect is not significantly different from the blank control. Figure 7 shown.

[0184] 7. This experiment also compared the moisturizing and repairing effects of the repair compositions of Example 5 and Comparative Example 17.

[0185] For the convenience of comparison, the repair composition is marked as sample A, and the composition using olive oil as a parallel replacement is marked as sample B. The test results show that after the avocado oil is replaced, the moisturizing power, skin smoothness and anti-inflammatory power are reduced. Figures 8-10 .

[0186] 8. The present application also compared the moisturizing effect of the cream product of Example 10 and the cream of the blank control group (not containing the repairing composition) for 48 hours (using the skin moisture measurement instrument Corneometer CM825). The cream of Example 10 has excellent moisturizing and skin repairing effects, such as Figure 11 shown.

[0187] 9. In vitro experiment: Repair of intercellular lipid membrane.

[0188] Experimental steps: After treating in vitro skin cells with SDS (sodium dodecyl sulfate) for 24 hours, the cell samples that have been damaged by SDS and repaired with moisturizing cream are fixed, dehydrated, embedded, and pre-treated to make ultra-thin slices. Then, they are placed in an electron microscope and observed and photographed at an appropriate magnification. Appropriate areas are selected from the captured images, and image analysis software is used to measure the length of the intercellular lipid membrane.

[0189] The results are as follows Figure 12 After 24 hours of SDS damage treatment, the moisturizing repair cream was able to regenerate the intercellular lipid membrane structure of the 3D reconstructed model of healthy skin.

[0190] Test Example 4: Comparison of product performance

[0191] 1. Compare the performance of the face cream product of Example 10, the hand cream product of Example 11, the body lotion product of Example 17, the face cream products of Comparative Examples 23 to 25, the hand cream products of Comparative Examples 35 to 37, and the body lotion products of Comparative Examples 44 to 46.

[0192] The results are shown in Table 8.

[0193] Table 8

[0194]

[0195] As shown in Table 8, when the shea butter content in the repair composition exceeds 30%, more problems will occur, such as: the product is not formed, the product has poor absorption, the paste becomes coarse, and there is an abnormal odor, etc. The following is a comparative test of different shea butter concentrations.

[0196] 2. Compare the shelf stability of the face cream product of Example 10, the hand cream product of Example 11, the body lotion product of Example 17, the face cream products of Comparative Examples 26 to 28, the hand cream products of Comparative Examples 38 to 40, and the body lotion products of Comparative Examples 47 to 49.

[0197] The results are shown in Table 9.

[0198] Table 9

[0199]

[0200] Phytosterol oleate belongs to plant sterols, and its structure and function are similar to cholesterol. Cholesterol is an important component of skin barrier health, forming intercellular lipids. Intercellular lipids and keratinocytes form a natural skin barrier, which can prevent skin moisture loss and resist external damage. When the concentration of phytosterol oleate added exceeds 3%, it is not conducive to the formation of stable bionic sebum, and it is easy to cause problems such as product discoloration and abnormal odor. The results are shown in Table 9.

[0201] 3. Comparison of the stability of the face cream product of Example 10, the hand cream product of Example 11, the body lotion product of Example 17, the face cream products of Comparative Examples 29-31, the hand cream products of Comparative Examples 41-43, and the body lotions of Comparative Examples 50-52. The results are shown in Table 10.

[0202] Table 10

[0203]

[0204] Ceramides are a class of amide compounds formed by the dehydration of long-chain fatty acids and the amino group of sphingosine. Ceramides primarily include ceramide phosphocholine and ceramide phosphoethanolamine. Phospholipids are the primary components of cell membranes, and ceramides make up 40% to 50% of sebum in the stratum corneum. Ceramides are a major component of the intercellular matrix and play a crucial role in maintaining moisture balance in the stratum corneum. Ceramides have a strong ability to bind water molecules, maintaining skin moisture by forming a network structure within the stratum corneum. Therefore, ceramides play a role in retaining skin moisture.

[0205] However, ceramide has very poor solubility. Not only is it insoluble in water, but it is also soluble in only a very small amount of oil. If it does not dissolve well, it is difficult to play a role in skin care. When the amount added to the formula exceeds 1%, it is difficult to dissolve in the formula, resulting in precipitation during the storage process after emulsification.

[0206] The present application provides a high-content shea butter repair composition for skin care, as well as its preparation method and application. The present application adopts a shea butter, avocado oil, avocado butter unsaponifiable matter, ceramide, phytosterol oleate, lactobacillus fermentation product, amino acid and bisabolol to repair and strengthen the four major barrier functions of the skin, resist the invasion of external physical, chemical, biological and other harmful factors, protect the body from damage, increase the skin's moisture content and strengthen the skin's barrier function, reduce the irritation of external substances to the skin, and keep the skin in the best health at all times.

[0207] The primary ingredient in this application, natural plant oil shea butter, is particularly effective in moisturizing and repairing the skin. Shea butter (shea butter, avocado oil) is primarily composed of triglycerides (including a certain amount of linoleic acid) and unsaponifiable matter. Triglycerides account for approximately 80% of the total triglyceride content, and the plant triglyceride composition is very balanced, with a high proportion of oleic acid (40-70%), a highly moisturizing property. It also contains a certain proportion of omega-6 fatty acids (linolenic acid), which provide essential fatty acids for deep and effective moisturization. The unsaponifiable matter content varies depending on the season, origin, and extraction and refining methods. Triterpenes, particularly cinnamate, absorb UVB rays, effectively combating UV inflammatory damage and environmentally-induced skin problems. It serves as a natural sunscreen and also promotes and protects collagen production, delaying aging.

[0208] This application also contains ceramide NP and phytosteryl oleate, which are combined with shea butter to form a bionic sebum film, filling the "mortar" inside the classic skin brick wall structure of the stratum corneum, playing a physical barrier repair role, thereby enhancing the keratinized cells and intercellular lipids in the stratum corneum to form a brick wall structure. The cells adhere together through cell connections to form a solid "protective wall", which together form a natural protective barrier for the human body, maintain skin moisture, prevent moisture evaporation, resist external stimuli and damage, effectively block the invasion of harmful external substances, and prevent excessive loss of water and nutrients in the body.

[0209] The present application also contains an ingredient, lactobacillus fermentation product, which is an inactivated lactobacillus that retains the complete cell wall structure of the bacteria, can regulate the microecological flora, can stimulate the skin to produce antimicrobial peptides, and enhance the skin's microecological barrier function, thereby enhancing the skin's ability to resist external irritants and enhancing the skin's resistance to pathogens.

[0210] This application also contains natural moisturizing factor amino acid components glycine, serine and alanine. Amino acids are one of the natural moisturizing factors in the skin and are also the basic components of protein. Moisturizers made with amino acids have excellent continuous moisturizing ability, helping to enhance the skin's water retention capacity, prevent the skin from losing water too quickly, and maintain a healthy chemical skin barrier function;

[0211] This application also contains bisabolol and natural shea butter unsaponifiables, which inhibit inflammation internally, enhance self-immunity externally, soothe the skin to reduce inflammatory reactions, repair the skin's immune system, and promote skin repair and healing.

[0212] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application and are not intended to limit the scope of protection of the present application. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application may be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present application.

Claims

1. A high-content shea butter repair composition for skin care, characterized in that, The composition includes the following components in percentage by mass: Avocado butter 10-30%, avocado oil 0.01-6.99%, avocado butter unsaponifiable matter 0.001-1%, ceramide 0.001-1%, phytosteryl oleate 0.01-3%, lactobacillus fermentation product 0.001-1%, amino acids 0.003-7%, and bisabolol 0.01-1%; The amino acids include 0.001-4% glycine, 0.001-2% serine and 0.001-1% alanine.

2. The high-content shea butter repair composition for skin care according to claim 1, wherein The composition includes the following components in percentage by mass: Avocado butter 10-20%, avocado oil 1-6%, avocado butter unsaponifiable matter 0.1-0.8%, ceramide 0.01-0.5%, phytosteryl oleate 0.1-2%, lactobacillus fermentation product 0.05-0.8%, glycine 0.01-2%, serine 0.01-1%, alanine 0.01-0.8% and bisabolol 0.1-0.8%.

3. The preparation method of the high-content shea butter repair composition for skin care according to claim 1 or 2, wherein The following steps are involved: A high-content shea butter repairing composition is obtained by mixing shea butter, shea oil, shea butter unsaponifiable matter, ceramide, phytosterol oleate, lactobacillus fermentation product, amino acid and bisabolol.

4. the application of the high-content shea butter repair composition for skin care as claimed in claim 1 or 2 in preparing a skin care product.

5. The use according to claim 4, characterized in that The skin care product includes at least one of a cream, a lotion, an essence and a gel.

6. The use according to claim 4, characterized in that The skin care product includes a body lotion.

7. A skin care product, characterized in that: The skin care product comprises the high-content shea butter repairing composition for skin care as claimed in claim 1 or 2.

8. The skin care product according to claim 7, wherein The addition amount of the high-content shea butter repairing composition for skin care is 10-35%.

9. The skin care product according to claim 7, wherein The skin care product includes at least one of a cream, a lotion, an essence and a gel.

10. The skin care product according to claim 7, wherein The skin care product further comprises at least one of 0.5-10% moisturizer, 0.1-0.5% thickener, 0.01-0.4% pH adjuster, 1-10% oil, 0.5-3% surfactant, 0.1-1.0% preservative, and 0.01-0.1% antioxidant.

11. The skin care product according to claim 10, wherein The humectant includes a polyol; The thickener comprises at least one of xanthan gum, cellulose gum, carbomer and sodium polyacrylate; The surfactant includes a nonionic or anionic surfactant; The preservative comprises at least one of phenoxyethanol, ethylhexylglycerin, 1,2-hexanediol and cinnamone; The antioxidant includes at least one of butylated hydroxytoluene, butylated hydroxyanisole, tert-butylhydroquinone and tocopherol.

12. A method for preparing the skin care product according to claim 10, characterized in that: The preparation method of the skin care product comprises the following steps: S1. Mix purified water, thickener, and humectant to obtain an aqueous phase; S2. Mixing a surfactant, an oil, avocado butter, avocado oil, avocado butter unsaponifiable matter, phytosteryl oleate, ceramide, bisabolol, and an antioxidant with heating and stirring to obtain an oil phase; S3. Add the oil phase in step S2 to the water phase in step S1 and homogenize and emulsify, then add a pH regulator, a lactobacillus fermentation product, amino acids and a preservative and mix and stir evenly to obtain a skin care product.

13. The method for preparing a skin care product according to claim 12, wherein: In said S2, the heating temperature is 75-85°C; In S3, the homogenization time is 10 to 15 minutes.

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