A penetration enhancing composition, its preparation method and application in makeup removing water

Abstract

The present application relates to a kind of penetration promoting composition and its preparation method and in make-up water application, belong to the technical field of cosmetics.A kind of penetration promoting composition includes the following components: Zannichellia palustris extract, agave stem extract, perilla extract, soybean polypeptide, humectant, emulsifier, surfactant, skin conditioner, preservative and solvent;The present application utilizes the composite formula composed of Zannichellia palustris extract, agave stem extract, perilla extract and soybean polypeptide etc., not only can deep cleaning and moisturize skin, also has multiple functions such as anti-inflammatory, anti-allergic and anti-aging.In addition, aloe vera leaf extract provides moisturizing and soothing, PEG-6 caprylic acid / capric acid glyceride is emulsified to promote penetration and assist stubborn makeup removal, cactus extract enhances the hydration of stratum corneum to improve the mild penetration of makeup removal ingredients, and the three synergistically achieve efficient makeup removal while reducing irritation and maintaining skin barrier function.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of cosmetics, and relates to a penetration-promoting composition, a preparation method thereof and application of the penetration-promoting composition in makeup removal water. BACKGROUND

[0002] As the first step in the skin care program, makeup removal plays a vital role. Makeup, especially oily makeup, remaining on the face can be regarded as oily dirt. If this dirt is not removed in time, it will block the pores, causing the skin cells to be unable to breathe smoothly. When the breathing of the cells is blocked, the metabolism function of the skin is also affected, thereby triggering a series of skin problems. If makeup is not removed completely for a long time, the skin will gradually lose its original delicate texture and become rough, and the pores will become more and more obvious, even expand. In addition, the skin color may become dull and lose luster, and due to the blockage of the pores, dark particles and acne are prone to grow on the skin surface. In order to deal with these makeup removal problems, a variety of makeup removal products are provided on the market, including makeup removal water, makeup removal cream, makeup removal oil and makeup removal paste, etc., which have different characteristics and can meet different skin types and makeup removal needs.

[0003] A moisturizing makeup removal water and a preparation method thereof are disclosed in Chinese Patent No. CN107898663A. The fruit peel and water are placed in a beaker, and the beaker is placed in a digital speed constant temperature magnetic stirrer for heating and stirring mixing to obtain a mixed solution. The mixed solution is filtered to obtain a fruit peel extract. The surfactant, carbomer, keratinase, water, plant essential oil, ethanol solution, frankincense, aloe pulp juice, preservative and fruit peel extract are ultrasonically dispersed to obtain a dispersion liquid. The dispersion liquid is placed in an incubator for constant temperature culture to obtain a pretreated mixed solution. The pretreated mixed solution is placed in a vertical electric field for polarization to obtain the moisturizing makeup removal water. The moisturizing makeup removal water provided by the present application has excellent makeup removal effect and long-acting moisturizing effect.

[0004] However, most of the makeup removal products in the prior art have single function, only having basic penetration-promoting cleaning and moisturizing functions, which are far from meeting the increasing needs of consumers. SUMMARY

[0005] The present application provides a penetration-promoting composition, a preparation method thereof and application of the penetration-promoting composition in makeup removal water. The components of the present application interact with each other through a complex formula, which not only can deeply clean and moisturize the skin, but also has multiple functions of anti-inflammation, anti-allergy and anti-aging.

[0006] The object of the present application can be achieved by the following technical solutions:

[0007] A penetration-promoting composition comprises the following components in parts by weight:

[0008]

[0009] As a preferred technical solution of the present application, the penetration enhancing composition further comprises the following components by weight fraction: humectant A 4-6 parts, emulsifier 3.5-4.2 parts, surfactant 2.8-3.4 parts, skin conditioner A 1.8-2.2 parts, preservative A 0.38-0.42 parts, preservative B 0.13-0.16 parts, skin conditioner B 0.09-0.12 parts, humectant B 0.010-0.012 parts, and solvent 88-95 parts.

[0010] As a preferred technical solution of the present application, the preparation of the Acanthophacium aristatum leaf extract comprises: drying, crushing, leaching, filtering and rotary evaporation of the Acanthophacium aristatum leaf to obtain the extract, the leaching solvent being 80% by volume concentration of n-butanol aqueous solution, the leaching time being 60-80 min, the leaching temperature being 62-68℃, and the solid-liquid ratio being 1g:15-20mL; wherein the leaching time of the Acanthophacium aristatum leaf extract of the examples and comparative examples is 70 min, the leaching temperature is 65℃, and the solid-liquid ratio is 1g:20mL.

[0011] As a preferred technical solution of the present application, the terpene in the Acanthophacium aristatum leaf extract has strong penetration enhancing ability and low toxicity, can improve skin permeability, and has penetration enhancing effect on both hydrophilic and lipophilic drugs.

[0012] As a preferred technical solution of the present application, the Agave americana extract can form competitive binding with keratin protein, weaken the hydrogen bond network hydration of the stratum corneum, form a co-penetration system with propylene glycol, and significantly improve the penetration coefficient of lipophilic ingredients.

[0013] As a preferred technical solution of the present application, the humectant A is propylene glycol; and the emulsifier is PEG-6 caprylic / capric glycerides.

[0014] As a preferred technical solution of the present application, the surfactant is composed of cocamidopropyl betaine, sodium benzoate and deionized water in a mass ratio of 61-64:37-39:0.4-0.5.

[0015] As a preferred technical solution of the present application, the skin conditioner A is a mixture of Aloe barbadensis leaf juice, Lactobacillus ferment, 1,2-hexanediol, cactus extract and p-hydroxyacetophenone in a mass ratio of 50:48.2:1.0:0.5:0.3.

[0016] As a preferred technical scheme of the present application, the lactic acid bacteria fermentation product is obtained after the lactic acid bacteria is cultured in a milk medium, and the product is obtained after impurities are removed; the cactus extract and the lactic acid bacteria fermentation product are mixed, then the aloe vera leaf juice is added and fermented for 12 hours, sterilized, and then 1,2-hexanediol and p-hydroxyacetophenone are added to obtain the skin conditioner A.

[0017] As a preferred technical scheme of the present application, the preservative A is phenoxyethanol; and the preservative B is chlorphenesin.

[0018] As a preferred technical scheme of the present application, the skin conditioner B is allantoin; the humectant B is sodium hyaluronate; and the solvent is deionized water.

[0019] As a preferred technical scheme of the present application, a preparation method of a penetration promoting composition comprises the following steps: uniformly dissolving the preservative B and 1 / 3 of the humectant A in advance to obtain a mixed solution; adding the solvent, the remaining humectant A, the skin conditioner B, the humectant B into an emulsifying kettle, stirring at 25-35 r / min, and heating to 80-85℃, then adding the mixed solution, sterilizing and keeping warm for 20 min, cooling to 40-45℃, and then adding the extract of reed leaves, the extract of agave stem, the extract of perilla, and the soybean polypeptide, stirring for 45-60 min, and then adding the emulsifier, the surfactant, the skin conditioner A, and the preservative A, stirring at 25-35 r / min for 10-20 min, filtering through a 300-mesh sieve, and then discharging.

[0020] As a preferred technical scheme of the present application, the penetration promoting composition is applied to makeup removing water.

[0021] The present application has the following beneficial effects:

[0022] The present application utilizes a complex formula composed of the extract of reed leaves, the extract of agave stem, the extract of perilla, and the soybean polypeptide, and the components interact with each other to produce unexpected positive effects. The makeup removing water not only inherits the penetration, cleaning, and moisturizing properties of traditional makeup removing products, but also has the ability to improve skin quality. DETAILED DESCRIPTION

[0023] In order to further illustrate the technical means and effects adopted by the present application to achieve the predetermined application purposes, the specific embodiments, structures, features, and effects according to the present application are described in detail below in combination with examples.

[0024] Example 1

[0025] A penetration promoting composition comprises the following components by weight:

[0026] Pteridium aquilinum extract 2 parts, Agave americana stem extract 3.0 parts, Perilla frutescens extract 1.0 part, soybean polypeptide 0.6 part, humectant A 4 parts, emulsifier 3.5 parts, surfactant 2.8 parts, skin conditioner A 1.8 parts, preservative A 0.38 part, preservative B 0.13 part, skin conditioner B 0.09 part, humectant B 0.010 part, and solvent 88 parts.

[0027] The humectant A is propylene glycol; the emulsifier is PEG-6 caprylic / capric glycerides; the surfactant is composed of cocamidopropyl betaine, sodium benzoate, and deionized water in a mass ratio of 61:37:0.4; the skin conditioner A is a mixture of Aloe barbadensis leaf juice, Lactobacillus ferment, 1,2-hexanediol, Opuntia extract, and p-hydroxyacetophenone in a mass ratio of 50:48.2:1.0:0.5:0.3; the preservative A is phenoxyethanol; the preservative B is chlorphenesin; the skin conditioner B is allantoin; the humectant B is sodium hyaluronate; and the solvent is deionized water.

[0028] A preparation method of a penetration-promoting composition includes the following steps:

[0029] The preservative B and 1 / 3 of the humectant A are uniformly dissolved in advance to obtain a mixed solution; the solvent, the remaining humectant A, the skin conditioner B, and the humectant B are added to an emulsifying kettle and stirred at 25 r / min while being heated to 80℃, and then the mixed solution is added for sterilization for 20 min; after being cooled to 40℃, the Pteridium aquilinum extract, the Agave americana stem extract, the Perilla frutescens extract, and the soybean polypeptide are added and stirred for 45 min; and then the emulsifier, the surfactant, the skin conditioner A, and the preservative A are added and stirred at 25 r / min for 10 min, and then filtered through a 300-mesh sieve to discharge.

[0030] Example 2

[0031] A penetration-promoting composition includes the following components in parts by weight:

[0032] Pteridium aquilinum extract 3 parts, Agave americana stem extract 3.8 parts, Perilla frutescens extract 1.3 part, soybean polypeptide 0.8 part, humectant A 5 parts, emulsifier 3.8 parts, surfactant 3.1 parts, skin conditioner A 2 parts, preservative A 0.4 part, preservative B 0.15 part, skin conditioner B 0.1 part, humectant B 0.011 part, and solvent 92 parts.

[0033] The humectant A is propylene glycol; the emulsifier is PEG-6 caprylic / capric glycerides; the surfactant is composed of cocamidopropyl betaine, sodium benzoate, and deionized water in a mass ratio of 62:38:0.45;

[0034] The skin conditioning agent A is a mixture of aloe barbadensis leaf juice, lactobacillus ferment, 1,2-hexanediol, opuntia extract and p-hydroxyacetophenone at a mass ratio of 50:48.2:1.0:0.5:0.3; the preservative A is phenoxyethanol; the preservative B is chlorphenesin; the skin conditioning agent B is allantoin; the humectant B is sodium hyaluronate; and the solvent is deionized water.

[0035] A preparation method of a penetration promoting composition includes the following steps:

[0036] The preservative B and 1 / 3 of the humectant A are uniformly dissolved in advance to obtain a mixed solution; the solvent, the remaining humectant A, the skin conditioning agent B, the humectant B are added into an emulsifying kettle and stirred at 30 r / min and heated to 82℃, then the mixed solution is added and sterilized for 20 min, and then the temperature is reduced to 42℃, and then the opuntia hirta leaf extract, the agave stem extract, the perilla extract and the soybean polypeptide are added and stirred for 52 min, and then the emulsifier, the surfactant, the skin conditioning agent A and the preservative A are added and stirred at 30 r / min for 15 min, and then filtered through a 300 mesh sieve and discharged.

[0037] Example 3

[0038] A penetration promoting composition includes the following components by weight fraction:

[0039] The opuntia hirta leaf extract is 4 parts, the agave stem extract is 4.5 parts, the perilla extract is 1.6 parts, the soybean polypeptide is 0.9 parts, the humectant A is 6 parts, the emulsifier is 4.2 parts, the surfactant is 3.4 parts, the skin conditioning agent A is 2.2 parts, the preservative A is 0.42 parts, the preservative B is 0.16 parts, the skin conditioning agent B is 0.12 parts, the humectant B is 0.012 parts, and the solvent is 95 parts.

[0040] The humectant A is propylene glycol; the emulsifier is PEG-6 caprylic / capric glycerides; and the surfactant is composed of cocamidopropyl betaine, sodium benzoate and deionized water at a mass ratio of 64:39:0.5;

[0041] The skin conditioning agent A is a mixture of aloe barbadensis leaf juice, lactobacillus ferment, 1,2-hexanediol, opuntia extract and p-hydroxyacetophenone at a mass ratio of 50:48.2:1.0:0.5:0.3; the preservative A is phenoxyethanol; the preservative B is chlorphenesin; the skin conditioning agent B is allantoin; the humectant B is sodium hyaluronate; and the solvent is deionized water.

[0042] A preparation method of a penetration promoting composition includes the following steps:

[0043] Dissolve preservative B and 1 / 3 of humectant A in advance to obtain a mixed solution; add solvent, the remaining humectant A, skin conditioner B, humectant B into an emulsifying kettle, stir at 35 r / min, heat to 85℃, then add the mixed solution, sterilize for 20 min, cool to 45℃, then add the extract of reed leaves, the extract of agave stem, the extract of perilla and the soybean polypeptide, stir for 60 min, then add emulsifier, surfactant, skin conditioner A and preservative A, stir at 35 r / min for 20 min, filter through a 300-mesh sieve, and discharge.

[0044] Comparative Examples 1-4

[0045] Comparative Examples 1-4 are different from Example 3 in that the amounts of the extract of reed leaves, the extract of agave stem, the extract of perilla and the soybean polypeptide are as shown in Table 1.

[0046] Table 1 (unit: weight parts)

[0047]

[0048] The remaining components, preparation steps and parameters are consistent.

[0049] Test Example 1

[0050] Seventy volunteers aged between 30 and 45 years old, who have dry skin problems, are selected, with 35 men and 35 women. These volunteers are randomly assigned to 7 groups, with 10 volunteers in each group. The composition is soaked in non-woven fabric, and applied to the corresponding test sample on the face area of the volunteers. The volunteers are required to apply the sample to the face area once a day in the morning and evening, each time for 1 min, for 14 days of continuous use.

[0051] On day 0 and day 14 of product use, the skin moisture content of the participants is measured using a skin moisture content tester Corneometer CM825. By analyzing the data changes before and after using the product, the moisturizing performance of different samples is evaluated. The results are shown in Table 2.

[0052] Table 2

[0053]

[0054]

[0055] As can be seen from Table 2, the composition in Examples 1-3 of the present application can effectively maintain the moisture on the surface of the skin, combined with the effect of the moisturizing ingredients, effectively prevent the loss of skin moisture, and thus achieve the purpose of moisturizing. In contrast, the composition in Comparative Examples 1-4 has a poor effect on maintaining the moisture on the surface of the skin.

[0056] Test Example 2

[0057] Select 80 mice weighing 20 ± 2 grams, half male and half female, after a week of feeding, randomly divided into groups. One group used normal saline as a control, the rest were divided into examples and comparative examples. All compounds were dissolved in sterile water to prepare a 30 mg / ml solution. At the beginning of the experiment, each mouse was coated with 0.05 mL of xylene on the right ear, and 0.05 mL of the corresponding composition was coated on the left ear after 30 minutes. The mice were sacrificed after 120 minutes, and both ears were weighed to calculate the ear swelling rate;

[0058] Ear swelling rate = (right ear weight - left ear weight) / left ear weight x 100%;

[0059] The results are shown in Table 3.

[0060] Table 3

[0061] Ear swelling rate (%) Example 1 10.2 Example 2 9.6 Example 3 9.8 Comparative Example 1 16.8 Comparative Example 2 15.2 Comparative Example 3 16.3 Comparative Example 4 14.9 Negative control group 19.4

[0062] As can be seen from Table 3, the compositions in Examples 1-3 of the present application can effectively inhibit inflammation, while the compositions in Comparative Examples 1-4 have poor anti-inflammatory effect.

[0063] From the results of Table 2 and Table 3, combined with examples and comparative examples, through comparative analysis, it can be known that the Gracilaria duraucrioides extract used in the present application contains rich Gracilaria duraucrioides flavonoids, can regulate the expression of mitogen-activated protein kinase and nuclear transcription factor NF-κB, has significant anti-inflammatory, analgesic and anti-allergic effects, the Agave americana stem extract contains a factor that inhibits free histamine, the soybean polypeptide can form a skin barrier by supplementing the amino acids and proteins required by the skin, the Perilla frutescens extract contains polyphenols that can inhibit inflammatory substances, and the α-linolenic acid in it can have a strong inhibitory effect on inflammation after combining with the soybean polypeptide, and the four have a significant synergistic effect on skin allergy.

[0064] Some specific amino acid sequences contained in the soybean polypeptide can stimulate the activity of skin cells and promote the synthesis of collagen and elastin, while the Agave americana stem extract contains a large amount of factors that inhibit elastase and collagenase, thus preventing the loss of the above-mentioned collagen, the Perilla frutescens extract increases the SOD activity of the skin and reduces the MDA level, and the Gracilaria duraucrioides contains flavonoids, polysaccharides and other components that can scavenge free radicals and have antioxidant effects, so the four have a synergistic effect of excellent moisturizing and anti-aging effect.

[0065] In addition, PEG-6 caprylic / capric glycerides as non-ionic surfactants can temporarily reduce barrier resistance by interfering with the arrangement of stratum corneum lipids, promote the penetration of hydrophilic / lipophilic ingredients, enhance the stability of the formula, help the dispersion of poorly soluble active ingredients, and indirectly improve the penetration efficiency.

[0066] Aloe barbadensis leaf extract contains polysaccharides (e.g. acemannan) and amino acids that soften the stratum corneum by hydration, indirectly promoting penetration of small molecules. Anti-inflammatory soothing ingredients (e.g. aloin) can reduce irritation that can be caused by penetration enhancers, increasing the mildness of the formulation. It can also act as a "moisturizing soothing agent" and is suitable for use in sensitive skin lotions to relieve dryness and redness. Aloe barbadensis leaf extract can be used in combination with PEG-6 glyceryl ester to reduce its potential for irritation.

[0067] Opuntia vulgaris extract contains mucopolysaccharides and antioxidant flavonoids that extend the residence time of active ingredients by forming a hydrophilic film, promoting slow penetration. It enhances skin hydration, indirectly increasing the efficiency of penetration. As a "natural moisturizing booster", Opuntia vulgaris extract can effectively enhance antioxidant and anti-pollution efficacy when used in combination with Aloe barbadensis leaf extract.

[0068] The above description is only the preferred embodiment of the present application, and is not intended to limit the present application in any form. Although the present application has been disclosed as above with the preferred embodiment, it is not intended to limit the present application, and any person skilled in the art can make some changes or modifications to the above disclosed technical content without departing from the scope of the present application, and any indirect modification, equivalent change and modification made according to the technical essence of the present application to the above embodiment are still within the scope of the present application.

Claims

1. A penetration enhancing composition characterized in that, By weight parts comprising the following components: Zizania caducifolia leaf extract 2-4 parts Agave stem extract 3.0-4.5 parts Perilla frutescens extract 1.0-1.6 parts Soybean polypeptide 0.6-0.9 parts; The said penetration promoting composition further comprises the following components by weight parts: humectant A 4-6 parts, emulsifier 3.5-4.2 parts, surfactant 2.8-3.4 parts, skin conditioner A 1.8-2.2 parts, preservative A 0.38-0.42 parts, preservative B 0.13-0.16 parts, skin conditioner B 0.09-0.12 parts, humectant B 0.010-0.012 parts and solvent 88-95 parts; the said humectant A is propylene glycol; the said emulsifier is PEG-6 glyceryl caprylate / caprate; the said surfactant consists of cocamidopropyl betaine, sodium benzoate and deionized water in a mass ratio of 61-64:37-39:0.4-0.5; the said preservative A is phenoxyethanol; the said preservative B is chlorphenesin; the said solvent is deionized water; The said skin conditioner A is a mixture of aloe barbadensis leaf juice, lactobacillus ferment, 1,2-hexanediol, cactus extract and p-hydroxyacetophenone in a mass ratio of 50:48.2:1.0:0.5:0.3; The preparation method of the said skin conditioner A is as follows: the said lactobacillus ferment is obtained by culturing lactobacillus in milk medium, and removing impurities; after mixing the cactus extract and the lactobacillus ferment, the aloe barbadensis leaf juice is added and fermented for 12 hours, sterilized, and then 1,2-hexanediol and p-hydroxyacetophenone are added to obtain the product; The said skin conditioner B is allantoin; the said humectant B is sodium hyaluronate.

2. A method of preparing a penetration enhancing composition as claimed in claim 1, characterized in that, The preparation method comprises the following steps: dissolving the preservative B and 1 / 3 of the humectant A uniformly in advance to obtain a mixed solution; adding the solvent, the remaining humectant A, the skin conditioner B, the humectant B into an emulsifying kettle, stirring at 25-35 r / min, and heating to 80-85℃, then adding the mixed solution, sterilizing for 20 min, cooling to 40-45℃, and then adding the Zizania caducifolia leaf extract, the Agave stem extract, the Perilla frutescens extract and the soybean polypeptide, stirring for 45-60 min, and then adding the emulsifier, the surfactant, the skin conditioner A and the preservative A, stirring at 25-35 r / min for 10-20 min, filtering through a 300 mesh sieve, and discharging.

3. The use of the penetration promoting composition according to claim 1 in makeup remover.

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