Parkinson's disease early screening equipment and screening system based on eye movement

Abstract

The present invention discloses an early screening device and screening system for Parkinson's disease based on eye movement, which belongs to the technical field of Parkinson's behavioral feature recognition. The early screening device and screening system for Parkinson's disease based on eye movement include a shell, one side of the upper end of the shell is provided with an operating screen for a built-in screening system, one side of the interior of the shell is provided with a storage cavity, and the lower end of the storage cavity is provided with a telescopic rod. The present invention solves the problem that the existing early screening system for Parkinson's disease has poor adaptability to different patients during the screening process. The second support arm of the present invention can drive the fixed frame at the front end to rotate after being driven by a motor, and adjust the fixed frame to face the seat cushion and the movable cavity respectively. A patient sitting in a wheelchair can move directly to the seat cushion position. Finally, the rotation of the fixed frame can cope with patients sitting on the upper end of the seat cushion and patients lying on the bed and close to the movable cavity position.

Description

Technical Field

[0001] The present invention relates to the technical field of Parkinson's disease behavioral feature recognition, and in particular to an early screening device and screening system for Parkinson's disease based on eye movement. Background Art

[0002] The Parkinson's disease early screening device is a medical device that identifies the early symptoms of Parkinson's disease by analyzing the patient's eye behavior characteristics. By analyzing these eye behavior data, the device can detect abnormal eye movement characteristics related to Parkinson's disease, thereby providing a basis for early screening and diagnosis. This non-invasive screening method has high sensitivity and specificity, and can detect potential risks in the early stages of the disease, providing patients with timely intervention and treatment opportunities. The application of this device helps to increase the early diagnosis rate of Parkinson's disease and improve the quality of life of patients.

[0003] Chinese patent publication number CN221635746U discloses an early screening system for Parkinson's disease, including a motion module to stimulate the subject's eye movement; a near-infrared light source for illuminating the eye movement test process; a camera module for recording eye movement conditions; and a processor module for processing and comparing the eye movement conditions and the movement differences of the motion module. The Parkinson's disease screening system in this utility model uses eye movement technology to record the eye movement stimulated by the motion module and compare the movement differences between the two to see whether they meet the characteristics of Parkinson's disease. It can be used for screening and diagnosis of the disease.

[0004] During the screening process, the above-mentioned patented early screening system for Parkinson's disease only provides a rotating chair for patients to sit on. However, the rotating chair is relatively fixed and cannot accommodate patients sitting in wheelchairs or patients lying in beds. It has poor adaptability to different patients and requires medical staff to assist patients in sitting on the rotating chair for testing. Summary of the Invention

[0005] The purpose of the present invention is to provide an early screening device and screening system for Parkinson's disease based on eye movement. After being driven by a motor, the second support arm can drive the fixed frame at the front end to rotate, and adjust the fixed frame to face the seat cushion and the active cavity respectively. When facing the active cavity, it can slide longitudinally with the rotation of the third threaded rod. On the other hand, the seat cushion and the support rod can be rotated and folded and stored inside the storage cavity, and a patient sitting in a wheelchair can move directly to the seat cushion position. Finally, the rotation of the fixed frame can cope with patients sitting on the upper end of the seat cushion and patients lying on the bed and close to the active cavity position, solving the problems raised in the above-mentioned background technology.

[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solutions: an early screening device and screening system for Parkinson's disease based on eye movement, comprising a shell, an operating screen for a built-in screening system is provided on one side of the upper end of the shell, a storage cavity is provided on one side of the interior of the shell, a telescopic rod is provided at the lower end of the interior of the storage cavity, a seat cushion rotatably connected via a first connecting shaft is provided at one end of the telescopic rod, an active cavity is provided on the other side of the interior of the shell, a third threaded rod and a sliding rod are provided at both ends of the interior of the active cavity, a second transmission block is provided between the sliding rod and the third threaded rod, a second support arm, a first support arm and a fixed frame are provided laterally at the upper end of the exterior of the second transmission block, the rotation of the second support arm can adjust the orientation of the fixed frame, and the adjustment of the orientation of the fixed frame combined with the folding of the seat cushion and the support rod can make the device adapt to patients lying on the bed, patients sitting on the upper end of the seat cushion, and patients sitting in a wheelchair and located at the seat cushion position.

[0007] Preferably, a first transmission block is provided at the upper end of the exterior of the fixed frame, which is embedded in the interior of the first support arm and slidably connected to the interior of the first support arm. The first transmission block is penetrated by a second threaded rod with a threaded fit. The second support arm is embedded in the interior of the second transmission block and rotatably connected to the interior of the second transmission block. The orientation of the fixed frame can be adjusted by rotating the fixed frame within the first transmission block. The adjustment of the orientation of the fixed frame can cope with patients lying on the bed and patients sitting on the cushion, so that the fixed frame can be worn on the patient's eyes.

[0008] Preferably, the fixed frame is rotatably connected to the first transmission block via a second connecting shaft, and a threaded nut is provided on the outside of the second connecting shaft. The nut can be rotated on the outside of the second connecting shaft to move toward the first transmission block, and the fixed frame can be fixed after the angle adjustment as the nut continues to rotate.

[0009] Preferably, the outside of the third threaded rod is threadedly engaged with the through position of the second transmission block, the outside of the sliding rod is slidingly connected to the through position of the second transmission block, and a roller is provided on one side of the second transmission block and the sliding position of the sliding rod. After the second transmission block is longitudinally and horizontally adjusted by rotating the third threaded rod, the second transmission block area wrapped around the outside of the sliding rod can be continuously supported and guided by the rotation of the roller.

[0010] Preferably, a connecting ring is provided at the rear end inside the shell, and universal wheels are provided at the four corners of the lower end of the connecting ring. The universal wheels can be supported and transmitted through the connecting ring, and the position of the universal wheels can be adjusted so that the universal wheels can drive the shell to move laterally after being extended.

[0011] Preferably, a first threaded rod is provided through the interior of the connecting ring, and the exterior of the first threaded rod cooperates with the internal thread of the connecting ring. The exterior of the first threaded rod is rotatably connected to the rear end of the interior of the outer shell. Support columns are provided between the four universal wheels distributed around it, and the exterior of the support columns is slidably connected to the interior of the connecting ring. The first threaded rod rotating inside the outer shell can facilitate driving the connecting ring, driving the connecting ring and adjusting the horizontal position of the universal wheel.

[0012] Preferably, connecting rods are extended on both sides of the first support arm toward the inside of the second support arm, and the connecting rods are rotatably connected to the second support arm. The connecting rods are welded and fixed to the first support arm, and the first support arm and the second support arm can be connected by the extended connecting rods. When the first support arm and the second support arm are stored in the active cavity, when the first support arm is rotated and folded to the side of the second support arm, the first support arm and the second support arm can be stored in the active cavity, completely covering the position of the active cavity.

[0013] The present invention provides another technical solution: an eye movement-based early screening system for Parkinson's disease. The screening system includes a user interaction and visualization module, a user identification and iris registration module, an eye movement data acquisition module, a Parkinson's disease feature analysis module, and a multimodal data management module, wherein:

[0014] The user identity recognition and iris registration module is used to complete user identity binding and iris feature encryption storage, assist in binding the data of the same user, and create new data for the first-time user to correspond to subsequent re-detection;

[0015] The eye movement data acquisition module is used to record the eye movement trajectory and dynamic parameters in real time, and to identify and capture the behavioral characteristics of the eye;

[0016] The Parkinson's disease feature analysis module is used to compare the eye behavior feature data collected by the eye movement data collection module with the set data to achieve disease risk assessment;

[0017] The multimodal data management module is used to store and compare the data analyzed by the Parkinson's disease feature analysis module. The analyzed data is the behavioral characteristics of the eyes. After the identity is indexed, the current detection data is bound to the identity.

[0018] The user interaction and visualization module is used to provide a doctor's interactive interface, which is directly displayed on the operation screen.

[0019] Preferably, the eye movement data acquisition module is used to record the eye movement trajectory and dynamic parameters in real time, and identify and capture the behavioral characteristics of the eye, including:

[0020] The patient's eyes are continuously tracked by a high-speed eye tracking camera to obtain a continuous video stream and a first image stream. The video stream and the first image stream are divided into time interval cells based on a timeline axis, with each time interval cell having a time span of 3 to 5 seconds. The initial images in the same time interval cell are screened from the video stream and the first image stream based on resolution, clarity, and composition perspective. A second image stream is formed by capturing key time frames in the video stream, and the first image stream and the second image stream are then used together as the screened objects.

[0021] Perform image processing on the initial image, use grayscale processing and image noise reduction processing to obtain the target analysis image;

[0022] Based on the timeline axis, the behavioral characteristics of the eyeballs in each target analysis image are identified and captured. The coordinate position of the pupil in each target analysis image is recorded, including changes in the pupil coordinate position and changes in the light reflected by the cornea. The gaze point and the scanning path are continuously recorded.

[0023] If the pupil stays in one area for longer than a first preset time length threshold, it is determined to be a fixation behavior; if the pupil moves quickly from one position to another, it is determined to be a saccadic behavior, where rapid movement means that the time interval between the pupil moving from one position to another is less than a second preset time length threshold;

[0024] The number of pupil gaze and saccade behaviors, as well as the gaze points and saccade paths within a period of time are counted, and a pupil motion trajectory change curve is drawn based on the changes in the pupil's coordinate position during the change process.

[0025] Preferably, the Parkinson's disease feature analysis module is used to compare the eye behavior feature data collected by the eye movement data collection module with the set data to achieve disease risk assessment, including:

[0026] Obtaining the diameters of both pupils based on the target analysis image, obtaining basic information and medical history of the patient, comparing the difference between the two pupils, and comparing the diameters and the difference between the two pupils with a preset standard pupil size for a normal user to obtain a first size deviation value. If the first size deviation between the diameters and the difference between the two pupils and the preset standard pupil size for a normal user is greater than a first preset deviation range, analyzing the pupil movement trajectory change curve;

[0027] The motion trajectory change curve is divided according to the test environment, and the motion trajectory change curve is compared with the preset standard pupil motion trajectory change curve under the same test environment.

[0028] The degree of deviation between the motion trajectory change curve and the preset standard pupil motion trajectory change curve is calculated using the following formula:

[0029]

[0030] in, The first trajectory deviation value between the motion trajectory change curve and the preset standard pupil motion trajectory change curve, n is the number of points on the motion trajectory change curve, is the coordinate value of the i-th point on the motion trajectory change curve, The preset standard pupil movement trajectory change curve is The coordinate value of the corresponding point;

[0031] If the degree of deviation between the trajectory change curve and the preset standard pupil movement trajectory change curve is greater than the preset deviation range, it is determined that the current patient is at risk of Parkinson's disease.

[0032] Compared with the prior art, the present invention has the following beneficial effects:

[0033] 1. When in use, the present invention can be adjusted to adapt to different usage environments. First, the seat cushion and the support rod can be rotated and extended to unfold from the storage cavity. The unfolding can facilitate the patient to sit directly and identify the patient's eye behavior characteristics. Secondly, the seat cushion and the support rod can be rotated and retracted to the inside of the storage cavity, which is convenient for patients sitting in a wheelchair to sit directly in the wheelchair to identify the patient's eye behavior characteristics. Thirdly, for patients who are inconvenient to move while lying in bed, the patient lies on the bed, and after the universal wheels are extended, the outer shell can be pushed and moved to the edge of the bed where the patient lies, and the fixed frame can rotate with the second transmission block as the center of the circle and slide longitudinally along the movable cavity. The longitudinal sliding can make the fixed frame face the patient lying on the bed. The equipment can adapt to different usage environments through adjustment, adapting to different usage environments while adapting to different patients.

[0034] 2. The seat cushion and support rod of the present invention can be rotated and folded, and can be directly retracted into the storage cavity after folding. Secondly, the second support arm and the first support arm can be folded and stored in the movable cavity after rotating through the connecting rod. The protruding structure outside the shell can be completely stored inside the shell. Complete storage facilitates the transfer and storage of the equipment, and avoids the protruding second support arm, first support arm, seat cushion and support rod affecting the transfer and storage of the equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 It is a schematic diagram of the overall external structure of the present invention;

[0036] Figure 2 This is a schematic diagram of the second support arm of the present invention sliding along the movable cavity;

[0037] Figure 3 This is a cross-sectional view of the internal structure of the storage cavity of the present invention;

[0038] Figure 4 For the present invention Figure 3 A partial enlarged view of area A in the middle;

[0039] Figure 5 This is a cross-sectional view of the internal structure of the housing of the present invention;

[0040] Figure 6 For the present invention Figure 5 A partial enlarged view of area B in the middle;

[0041] Figure 7 This is a schematic diagram of the external structure of the connecting ring of the present invention;

[0042] Figure 8 This is a schematic diagram of the internal structure of the fixing frame of the present invention;

[0043] Figure 9 Schematic diagram of the screening system of the present invention.

[0044] In the figure: 1. outer shell; 2. telescopic rod; 3. seat cushion; 4. support rod; 5. connecting plate; 6. first connecting shaft; 7. movable cavity; 8. operating screen; 9. first threaded rod; 10. first support arm; 11. second support arm; 12. second threaded rod; 13. fixing frame; 14. first transmission block; 15. second connecting shaft; 16. second transmission block; 18. handle; 19. storage cavity; 20. connecting ring; 21. universal wheel; 22. support column; 23. third connecting shaft; 24. nut; 25. third threaded rod; 26. sliding rod; 27. roller; 28. stimulus presentation display screen; 29. ​​multispectral iris recognition camera; 30. high-speed eye tracking camera; 31. multispectral lighting; 32. connecting rod. DETAILED DESCRIPTION

[0045] The present invention will be further described below with reference to specific embodiments.

[0046] Example 1: Figure 1 and Figure 2 As shown, the eye movement-based early screening device for Parkinson's disease of this embodiment includes a housing 1, and a fixing frame 13 is provided at the front end of the housing 1. When performing early screening for Parkinson's disease based on eye movement, the fixing frame 13 needs to completely cover the patient's eyes to prevent external objects from affecting the detection;

[0047] A stimulus presentation display screen 28 is provided in the middle of the fixed frame 13 . The stimulus presentation display screen 28 is used to display the eye movement test task, and the movable objects are displayed on the stimulus presentation display screen 28 .

[0048] A high-speed eye tracking camera 30 is provided on one side of the fixed frame 13 to capture eye movement trajectories. A multispectral iris recognition camera 29 is provided on the other side of the fixed frame 13 to collect and recognize the patient's iris features.

[0049] In order to illuminate the interior of the fixed frame 13 and assist the high-speed eye tracking camera 30 and the multispectral iris recognition camera 29 in accurately detecting the patient's eyes, a multispectral lighting lamp 31 is provided in the middle of the upper end of the fixed frame 13. The multispectral lighting lamp 31 provides the required illumination for iris recognition and eye tracking, thereby improving the accuracy of iris recognition and eye tracking.

[0050] In order to facilitate the patient to sit directly at the front of the shell 1 for early screening of Parkinson's disease, the patient's eye behavior characteristics are directly identified, such as Figure 3 As shown, a storage cavity 19 is provided on one side of the interior of the housing 1. A telescopic rod 2 is provided at the lower end of the interior of the storage cavity 19. A seat cushion 3 is provided at one end of the telescopic rod 2. The seat cushion 3 can be extended from the storage cavity 19 by directly pulling the seat cushion 3, and can be retracted into the storage cavity 19 by pressing the seat cushion 3.

[0051] Among them, a support rod 4 is provided on the other side of the outside of the seat cushion 3, and the support rod 4 and the seat cushion 3 are rotatably connected through the third connecting shaft 23, and the seat cushion 3 and the telescopic rod 2 are rotatably connected through the first connecting shaft 6. After the support rod 4, the seat cushion 3 and the telescopic rod 2 are rotated through the first connecting shaft 6 and the third connecting shaft 23 respectively, the seat cushion 3 can be unfolded, and the seat cushion 3 can be placed on the front end of the outer wall of the shell 1, and the lower end of the seat cushion 3 is supported by the unfolded support rod 4 between the ground, which can facilitate the person being tested to sit on the upper end of the seat cushion 3;

[0052] In addition, for patients who are sitting in a wheelchair, the support rod 4 and the seat cushion 3 can be folded and stored in the storage cavity 19, so that the protrusion of the seat cushion 3 and the support rod 4 will not affect the patient sitting in the wheelchair.

[0053] In order to facilitate adjustment of the fixed frame 13 to adapt to the recognition of eye behavior characteristics of different patients, an active cavity 7 is provided on the other side of the interior of the housing 1. A third threaded rod 25 is provided at the rear end of the movable cavity 7, and a sliding rod 26 is provided at the front end of the movable cavity 7. A second transmission block 16 is provided between the sliding rod 26 and the third threaded rod 25. The second transmission block 16 slides along the third threaded rod 25 and the sliding rod 26 to adjust the horizontal position of the fixed frame 13, so that the fixed frame 13 can be used with different patients lying in bed;

[0054] The second support arm 11 is provided at the upper end of the outer portion of the second transmission block 16, and the second support arm 11 is embedded in the interior of the second transmission block 16 and is rotatably connected thereto. The first support arm 10 is provided facing the fixed frame 13, and the first transmission block 14 is provided at the upper end of the outer portion of the fixed frame 13, and the first transmission block 14 is embedded in the interior of the first support arm 10 and is slidably connected thereto. By driving, the second support arm 11 can slide within the second transmission block 16 and adjust the fixed angle of the fixed frame 13.

[0055] In addition, if Figure 8 As shown, a second threaded rod 12 is provided through the position where the first transmission block 14 slides inside the first support arm 10, and the outer portion of the second threaded rod 12 is threadedly engaged with the first transmission block 14. Manually twisting the second threaded rod 12 can directly drive the fixed frame 13 connected to the lower end to slide horizontally. The fixed frame 13 slides along the first support arm 10 to further adapt to the usage needs of different patients.

[0056] The fixed frame 13 and the first transmission block 14 are rotatably connected via a second connecting shaft 15. Figure 4 As shown, a nut 24 is provided on the outside of the second connecting shaft 15, and the inside of the nut 24 is engaged with the external thread of the second connecting shaft 15. After the fixing frame 13 rotates with the second connecting shaft 15 as the center and adjusts its direction, the nut 24 is twisted on the outside of the second connecting shaft 15. As the nut 24 clings to the first transmission block 14 to fix the fixed frame 13 after the angle is adjusted, the fixed frame 13 can be flipped so that the stimulation presentation display screen 28 faces the patient lying flat on the bed;

[0057] When the second support arm 11, the first support arm 10 and the first transmission block 14 drive the fixed frame 13 to slide longitudinally to adjust the horizontal position, the second support arm 11, the first support arm 10 and the first transmission block 14 first rotate in the second transmission block 16 and slide along the movable cavity 7;

[0058] In order to improve the stability of the second support arm 11 and the first support arm 10 sliding longitudinally in the movable cavity 7, the outer portion of the third threaded rod 25 is threadedly engaged with the through position of the second transmission block 16, and the outer portion of the sliding rod 26 is slidably connected with the through position of the second transmission block 16, as shown in FIG. Figure 6 and Figure 7 As shown, a roller 27 is provided on one side of the sliding position of the second transmission block 16 and the sliding rod 26. When the third threaded rod 25 rotates and adjusts the horizontal positions of the second support arm 11 and the first support arm 10, one side of the second transmission block 16 is driven by thread engagement, while the other side of the second transmission block 16 is in contact with the sliding rod 26 through the roller 27 and supports the longitudinal sliding sliding rod 26.

[0059] In order to adjust the position of the device when it is used in an emergency, a connecting ring 20 is provided at the rear end of the housing 1. Universal wheels 21 are provided at the four corners of the lower end of the connecting ring 20. The universal wheels 21 are uniformly pushed and driven by the connecting ring 20. Figure 5 As shown, a first threaded rod 9 is provided inside the connecting ring 20, and the outer portion of the first threaded rod 9 is engaged with the inner thread of the connecting ring 20. The outer portion of the first threaded rod 9 is rotatably connected to the rear end of the inner portion of the housing 1. By twisting the first threaded rod 9, the horizontal position of the universal wheel 21 can be longitudinally adjusted.

[0060] In order to improve the stability of the longitudinal sliding of the connecting ring 20, support columns 22 are provided between the four universal wheels 21 distributed around it, and the outer portion of the support columns 22 is slidably connected to the inner portion of the connecting ring 20. When the connecting ring 20 slides longitudinally after being driven by the first threaded rod 9, the connecting ring 20 slides along the support columns 22. The four support columns 22 support and restrict the sliding connecting ring 20, thereby improving stability.

[0061] In order to facilitate the storage, storage and movement of the equipment, to avoid the protruding first support arm 10 affecting the movement, and to avoid the protruding first support arm 10 causing the first support arm 10 and the fixed frame 13 at the lower end to collide, the first support arm 10 is provided with connecting rods 32 extending from both sides of the second support arm 11. The connecting rods 32 are rotatably connected to the second support arm 11. The connecting rods 32 are welded and fixed to the first support arm 10. After driving the first support arm 10, the first support arm 10 can be rotated outside the second support arm 11 through the connecting rods 32, rotated and folded into the inside of the movable cavity 7. At the same time, the rotation of the first support arm 10 can drive the fixed frame 13 to be stored in the inside of the movable cavity 7 at the same time.

[0062] Among them, a connecting piece 5 is provided at the front end of the interior of the housing 1, and the lower end of the connecting piece 5 is rotatably connected to the front end of the interior of the housing 1. The four corners of the interior of the connecting piece 5 are provided with reserved through holes. After the connecting piece 5 is turned over, the bolts passing through the four corners of the connecting piece 5 can fix the housing 1;

[0063] In order to further understand the content of the present invention, as Figure 9 As shown, this embodiment provides the following technical solutions:

[0064] The screening system of the early screening device for Parkinson's disease based on eye movement includes an operation screen 8, which is located on one side of the upper end of the housing 1. The operation screen 8 has a built-in screening system, which is composed of a user interaction and visualization module, a user identity recognition and iris registration module, an eye movement data acquisition module, a Parkinson's disease feature analysis module and a multimodal data management module.

[0065] The user identity recognition and iris registration module is used to complete user identity binding and iris feature encryption storage. The multispectral iris recognition camera 29 collects and recognizes the data obtained from the iris features, and assists the user interaction and visualization module in completing the iris feature binding. After the iris is detected again, the data of the same user is assisted in binding. For the first-time user, new data is created to correspond to the subsequent re-detection.

[0066] The eye movement data acquisition module is used to record eye movement trajectories and dynamic parameters in real time. After the target that needs to be looked at is displayed on the surface of the stimulation presentation display screen 28, the high-speed eye tracking camera 30 continuously tracks the patient's eyes, identifies and captures the patient's eye behavior characteristics, and realizes early screening of Parkinson's disease based on eye movement. In addition, during the process of being filmed by the high-speed eye tracking camera 30, the eye movement data acquisition module filters out abnormal data generated by blinking.

[0067] The Parkinson's disease feature analysis module is used to compare the eye behavior feature data collected by the eye movement data collection module with the set data to achieve disease risk assessment;

[0068] The multimodal data management module is used to securely store and compare historical data analyzed by the Parkinson's disease feature analysis module. The analyzed data is the behavioral characteristics of the eyes. The irises collected by the user identification and iris registration module are only used for identity indexing. Once the identity is indexed, the current test data is bound to that identity to facilitate subsequent historical data queries.

[0069] The user interaction and visualization module is used to provide a doctor's interactive interface, which is directly displayed on the operation screen 8. The doctor's operating instructions and the analysis report obtained by the Parkinson's disease feature analysis module can be directly displayed on the operation screen 8, which can be directly viewed by medical staff to view the effect of the device on the patient's eye behavior feature recognition.

[0070] Preferably, the eye movement data acquisition module is used to record the eye movement trajectory and dynamic parameters in real time, and identify and capture the behavioral characteristics of the eye, including:

[0071] The high-speed eye tracking camera 30 continuously tracks the patient's eyeballs to obtain a continuous video stream and a first image stream. The video stream and the first image stream are divided into time interval cells based on a timeline axis, with each time interval cell having a time span of 3 to 5 seconds. The initial images in the same time interval cell are screened from the video stream and the first image stream based on resolution, clarity, and composition perspective. A second image stream is formed by capturing key time frames in the video stream. The first image stream and the second image stream are then used together as the screened objects.

[0072] Perform image processing on the initial image, use grayscale processing and image noise reduction processing to obtain the target analysis image;

[0073] Based on the timeline axis, the behavioral characteristics of the eyeballs in each target analysis image are identified and captured. The coordinate position of the pupil in each target analysis image is recorded, including changes in the pupil coordinate position and changes in the light reflected by the cornea. The gaze point and scanning path are continuously recorded.

[0074] If the pupil stays in one area for longer than a first preset time length threshold, it is determined to be a fixation behavior; if the pupil moves quickly from one position to another, it is determined to be a saccadic behavior, where rapid movement means that the time interval between the pupil moving from one position to another is less than a second preset time length threshold;

[0075] The number of pupil gaze behaviors and saccade behaviors, as well as the gaze points and saccade paths within a period of time are counted, and a pupil movement trajectory change curve is drawn based on the changes in the pupil's coordinate position during the change process.

[0076] The principle and effect of the above technical solution are as follows: the video stream and the first picture stream are obtained by continuously tracking the patient's eyeballs through the high-speed eye tracking camera 30. The video stream can ensure continuity, but it occupies a large amount of memory and cannot be directly analyzed for features. The video stream needs to be converted into a second picture stream by taking screenshots of key time frames, and the first picture stream and the second picture stream are merged together, sorted according to time, and then divided according to the timeline axis. Some preliminary images are first screened out based on resolution, clarity and composition perspective, and then target analysis images that can be used for specific analysis are screened out from the preliminary images. Changes in the pupil coordinate position and changes in the light reflected by the cornea are used as references to determine whether the patient has Parkinson's disease. Considering factors, in general, patients with early symptoms of Parkinson's disease have different changes in pupil patterns when stimulated by an experimental environment. For example, patients are required to track the movement of a fixed target point in an experimental environment, or to select a specified target object from multiple target points. The reaction sensitivity of the pupils of patients with Parkinson's disease is lower than that of ordinary people, and the number of scanning behaviors is less than that of ordinary people. By continuously recording the gaze point and scanning path, combined with the pupil coordinate position, a curve of pupil movement trajectory changes can be drawn, which can be used as a basis for judging whether the patient has early symptoms of Parkinson's disease. The above technical solution assists medical staff, improves the accuracy of analysis, and provides an analysis basis for objectively analyzing whether the patient has Parkinson's disease.

[0077] Specifically, the Parkinson's disease feature analysis module is used to compare the eye behavior feature data collected by the eye movement data collection module with the set data to achieve disease risk assessment, including:

[0078] Based on the target analysis image, the diameters of both pupils are obtained, basic information and medical history of the patient are obtained, the difference between the two pupils is compared, and the diameters and the difference between the two pupils are compared with a preset standard pupil size for a normal user to obtain a first size deviation value. If the first size deviation value of the two is greater than a first preset deviation range, the pupil movement trajectory change curve is analyzed;

[0079] The motion trajectory change curve is divided according to the test environment, and the motion trajectory change curve is compared with the preset standard pupil motion trajectory change curve under the same test environment.

[0080] The degree of deviation between the motion trajectory change curve and the preset standard pupil motion trajectory change curve is calculated using the following formula:

[0081]

[0082] in, The first trajectory deviation value between the motion trajectory change curve and the preset standard pupil motion trajectory change curve, n is the number of points on the motion trajectory change curve, is the coordinate value of the i-th point on the motion trajectory change curve, The preset standard pupil movement trajectory change curve is The coordinate value of the corresponding point;

[0083] If the degree of deviation between the trajectory change curve and the preset standard pupil movement trajectory change curve is greater than the preset deviation range, it is determined that the current patient is at risk of Parkinson's disease.

[0084] The principle and effect of the above technical solution are as follows: in the process of determining whether a patient has Parkinson's symptoms, the patient's basic information and medical history are first obtained. The diameter values ​​of the patient's bilateral pupils and the difference between the two pupils are then preliminarily analyzed. Parkinson's patients generally have abnormal pupil reflexes, including different pupil sizes or increased pupil diameters. By analyzing the first size deviation value, some ordinary patients who do not meet these symptoms can be screened out. In this screened population, the motion trajectory change curve is further analyzed and compared with a preset standard pupil motion trajectory change curve for ordinary people. The preset standard pupil motion trajectory change curve can be obtained by simulating the pupil reactions of ordinary people under the same test environment based on an AI model, or it can be pre-set based on empirical data. When comparing the motion trajectory change curve with the preset standard pupil motion trajectory change curve, the first trajectory deviation value can reflect the difference between the two. If the degree of deviation between the two trajectories is greater than the preset deviation range, the current patient is judged to be at risk for Parkinson's disease. The above judgment method combines multiple factors to determine whether a patient meets the symptoms of Parkinson's disease, making it more reliable.

[0085] Example 2: Figure 1 As shown, a handle 18 is provided between the other side of the upper end of the shell 1 and the outer wall of the operation screen 8, and the two ends of the handle 18 are respectively welded and fixed to the operation screen 8 and the shell 1. The shell 1 can be pushed by the reserved handle 18, which is convenient for the user to push the shell 1 and move the entire device.

[0086] Working principle: When the device is used and the patient's eye movement is used to realize behavioral feature recognition and early screening of Parkinson's disease, when the shell 1 moves, the rotation of the first threaded rod 9 pushes the connecting ring 20, and the connecting ring 20 drives the universal wheel 21 to extend from the lower end of the shell 1. The user can push the handle 18 to move it laterally when the universal wheel 21 rotates. When the seat cushion 3 is needed for the patient to sit directly, the seat cushion 3 and the support rod 4 are pulled from the storage chamber 19, and the seat cushion 3 and the support rod 4 are rotated with the first connecting shaft 6 as the center of the circle. The support rod 4 rotates on the side of the seat cushion 3 and is supported on the ground. When the seat cushion 3 is not in use, the support rod 4 rotates and fits on the side of the seat cushion 3. The seat cushion 3 and the support rod 4 rotate with the first connecting shaft 6 as the center and slide horizontally into the storage cavity 19. After the patient sits on the seat cushion 3 or moves to the seat cushion 3 in a wheelchair, the first support arm 10 and the second support arm 11 rotate in the second transmission block 16 and drive the fixed frame 13 toward one side of the seat cushion 3. When the patient lies on the bed and receives the test, the housing 1 is moved by the universal wheel 21 Rotate and move to the side of the bed, the first support arm 10 and the second support arm 11 rotate in the second transmission block 16 and drive the fixed frame 13 toward the movable cavity 7. After being driven by the motor, the third threaded rod 25 drives the second transmission block 16 through the sliding rod 26 and slides along the third threaded rod 25 to adjust the horizontal position of the fixed frame 13. At the same time, the fixed frame 13 rotates inside the first transmission block 14 with the second connecting axis 15 as the center of the circle, so that the stimulus presentation display screen 28 inside the fixed frame 13 faces the patient at the top of the bed. When finally adapting to the patient, the rotation of the second threaded rod 12 can drive the lower end of the fixed frame 13 to slide along the first support arm 10 through the first transmission block 14, further adapting the patient's eye position, so that the fixed frame 13 can completely cover the patient's eyes. When recognizing eye behavior characteristics, the stimulus presentation display screen 28 displays a movable target that the patient needs to look at. The high-speed eye tracking camera 30 tracks the patient's eyeballs when observing the target, and the multi-spectral lighting 31 fills the area inside the fixed frame 13 with light.

[0087] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0088] While the embodiments of the present invention have been shown and described, it will be apparent to those skilled in the art that various changes, modifications, substitutions, and alterations can be made to the embodiments without departing from the principles and spirit of the invention.

Claims

1. An eye movement-based early screening device for Parkinson's disease, comprising a housing (1), an upper side of the housing (1) being provided with an operating screen (8) with a built-in screening system, characterized in that: A storage cavity (19) is provided on one side of the interior of the shell (1), a telescopic rod (2) is provided on the lower end of the interior of the storage cavity (19), a seat cushion (3) rotatably connected to the seat cushion (3) via a first connecting shaft (6) is provided on one end of the telescopic rod (2), an activity cavity (7) is provided on the other side of the interior of the shell (1), a third threaded rod (25) and a sliding rod (26) are provided at both ends of the interior of the activity cavity (7), a second transmission block (16) is provided between the sliding rod (26) and the third threaded rod (25), a second support arm (11), a first support arm (10) and a fixed frame (13) are provided on the upper end of the exterior of the second transmission block (16), a stimulus presentation display screen (28) is provided in the middle of the interior of the fixed frame (13), and the stimulus presentation display screen (28) is used to display an eye movement test task; a high-speed eye tracking camera (30) is provided on one side of the interior of the fixed frame (13), and a multi-spectral iris recognition camera (29) is provided on the other side of the interior of the fixed frame (13).

2. The eye movement-based early screening device for Parkinson's disease according to claim 1, characterized in that: The upper end of the fixed frame (13) is provided with a first transmission block (14) embedded in the first support arm (10) and slidably connected to the interior of the first support arm (10), the first transmission block (14) passes through a second threaded rod (12) with threaded engagement, and the second support arm (11) is embedded in the second transmission block (16) and rotatably connected to the interior of the second transmission block (16).

3. The eye movement-based early screening device for Parkinson's disease according to claim 2, characterized in that: The fixed frame (13) and the first transmission block (14) are rotatably connected via a second connecting shaft (15), and a nut (24) with threaded fit is provided on the outside of the second connecting shaft (15).

4. The eye movement-based early screening device for Parkinson's disease according to claim 1, characterized in that: The outer portion of the third threaded rod (25) is threadably engaged with the through position of the second transmission block (16), the outer portion of the sliding rod (26) is slidably connected to the through position of the second transmission block (16), and a roller (27) is provided on one side of the sliding position between the second transmission block (16) and the sliding rod (26).

5. The eye movement-based early screening device for Parkinson's disease according to claim 4, characterized in that: A connecting ring (20) is provided at the rear end of the housing (1), and universal wheels (21) are provided at the four corners of the lower end of the connecting ring (20).

6. The eye movement-based early screening device for Parkinson's disease according to claim 5, characterized in that: A first threaded rod (9) is provided inside the connecting ring (20), and the outside of the first threaded rod (9) is engaged with the internal thread of the connecting ring (20). The outside of the first threaded rod (9) is rotatably connected to the rear end of the inside of the housing (1). Support columns (22) are provided between the four universal wheels (21) distributed around the connecting ring, and the outside of the support columns (22) is slidably connected to the inside of the connecting ring (20).

7. The eye movement-based early screening device for Parkinson's disease according to claim 2, characterized in that: Connecting rods (32) are provided on both sides of the first supporting arm (10) extending toward the interior of the second supporting arm (11); the connecting rods (32) are rotatably connected to the second supporting arm (11); and the connecting rods (32) are fixed to the first supporting arm (10) by welding.

8. A screening system for an eye movement-based early screening device for Parkinson's disease, applied to the eye movement-based early screening device for Parkinson's disease as claimed in claim 1, characterized in that: The screening system includes a user interaction and visualization module, a user identification and iris registration module, an eye movement data acquisition module, a Parkinson's disease feature analysis module and a multimodal data management module. The eye movement data acquisition module uses a high-speed eye tracking camera (30), wherein: The user identification and iris registration module is used to complete user identity binding and iris feature encryption storage, assist in binding the data of the same user, and create new data for the first-time user to correspond to subsequent re-testing, wherein a multi-spectral iris recognition camera (29) is used to collect and identify iris features; Eye movement data acquisition module, used to record eye movement trajectory and dynamic parameters in real time, and identify and capture eye behavior characteristics; The Parkinson's disease feature analysis module is used to compare the eye behavior feature data collected by the eye movement data collection module with the set data to achieve disease risk assessment; The multimodal data management module is used to store and compare historical data analyzed by the Parkinson's disease feature analysis module. The analyzed data is the behavioral characteristics of the eyes. After the identity is indexed, the current test data is bound to the identity. The user interaction and visualization module is used to provide a doctor interaction interface, which is directly displayed on the operation screen (8).

9. The screening system for early Parkinson's disease screening device based on eye movement according to claim 8, characterized in that: The eye movement data acquisition module is used to record eye movement trajectories and dynamic parameters in real time, and to identify and capture eye behavior characteristics, including: The patient's eyeballs are continuously tracked by a high-speed eye tracking camera (30) to obtain a continuous video stream and a first picture stream, the video stream and the first picture stream are divided into time interval cells based on a timeline axis, and the time span of each time interval cell is 3 to 5 seconds, and the initial image in the same time interval cell is screened from the video stream and the first picture stream based on resolution, clarity and composition perspective, wherein a second picture stream is formed by screenshotting a key time frame in the video stream, and then the first picture stream and the second picture stream are used as the screened objects together; Perform image processing on the initial image, use grayscale processing and image noise reduction processing to obtain the target analysis image; Based on the timeline axis, the behavioral characteristics of the eyeballs in each target analysis image are identified and captured. The coordinate position of the pupil in each target analysis image is recorded, including changes in the pupil coordinate position and changes in the light reflected by the cornea. The gaze point and the scanning path are continuously recorded. If the pupil stays in one area for longer than a first preset time length threshold, it is determined to be a fixation behavior; if the pupil moves quickly from one position to another, it is determined to be a saccadic behavior, where rapid movement means that the time interval between the pupil moving from one position to another is less than a second preset time length threshold; The number of pupil gaze and saccade behaviors, as well as the gaze points and saccade paths within a period of time are counted, and a pupil motion trajectory change curve is drawn based on the changes in the pupil's coordinate position during the change process.

10. The screening system for early Parkinson's disease screening device based on eye movement according to claim 9, characterized in that: The Parkinson's disease feature analysis module is used to compare the eye behavior feature data collected by the eye movement data acquisition module with the set data to achieve disease risk assessment, including: Obtaining the diameters of both pupils based on the target analysis image, obtaining basic information and medical history of the patient, comparing the difference between the two pupils, and comparing the diameters and the difference between the two pupils with a preset standard pupil size for a normal user to obtain a first size deviation value. If the first size deviation value is greater than a first preset deviation range, analyzing the pupil movement trajectory change curve; The motion trajectory change curve is divided according to the test environment, and the motion trajectory change curve is compared with the preset standard pupil motion trajectory change curve under the same test environment; The degree of deviation between the motion trajectory change curve and the preset standard pupil motion trajectory change curve is calculated using the following formula: in, is the first trajectory deviation value between the motion trajectory change curve and the preset standard pupil motion trajectory change curve, n is the number of points on the motion trajectory change curve, is the coordinate value of the i-th point on the motion trajectory change curve, The preset standard pupil movement trajectory change curve is The coordinate value of the corresponding point; If the degree of deviation between the trajectory change curve and the preset standard pupil movement trajectory change curve is greater than the preset deviation range, it is determined that the current patient is at risk of Parkinson's disease.

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