A whitening, sun protection composition, whitening sunscreen, method of preparation, use

Abstract

The present application relates to the daily chemical technology field, especially to a whitening and sunscreen composition, a whitening sunscreen cream, a preparation method and application.The composition comprises a solvent, a filler, a sunscreen agent, a moisturizing agent, an emollient, a whitening agent, an emulsifier, a thickening agent, a coloring agent, a pH regulator, a skin protective agent, an antioxidant, a fragrance agent and a chelating agent.The sunscreen cream provided by the present application has a relatively thick and creamy texture, can form a uniform and thick protective film after being applied, and can better resist ultraviolet rays.The adhesion on the skin is relatively strong, and the sunscreen cream is not easy to fall off due to sweat or friction.A light and thin protective film is formed on the skin, and the sunscreen cream does not burden the skin, has good fluidity and extensibility, is easy to uniformly apply, ensures that the sunscreen agent is more uniformly distributed on the surface of the skin, and provides more comprehensive protection.The light and thin texture does not affect the adhesion of the subsequent base makeup, and avoids the phenomenon of mud rubbing or card lines.

Description

Technical Field

[0001] This invention relates to the field of daily chemical technology, and in particular to a whitening and sun protection composition, a whitening and sun protection cream, a preparation method, and an application. Background Technology

[0002] Whitening skincare products are a type of skincare product whose main functions are to brighten skin tone, reduce pigmentation, and improve dull skin.

[0003] The main principles of whitening skincare products are: 1. Inhibiting melanin production: Reducing melanin production by intervening in tyrosinase activity; 2. Accelerating melanin metabolism: Promoting the shedding of aged keratinocytes and accelerating melanin excretion; 3. Antioxidant effect: Preventing oxidative damage and pigmentation to the skin caused by free radicals; 4. Protection and repair: Providing UV protection and reducing photodamage and photoaging.

[0004] Sunscreen is a skin care product that protects the skin from ultraviolet (UV) damage. Its main function is to reduce photodamage and photoaging of the skin by absorbing, reflecting, or scattering ultraviolet rays.

[0005] Physical sunscreens work by reflecting or scattering ultraviolet (UV) rays; chemical sunscreens absorb UV rays and release them as heat. They are classified by the wavelength of UV protection: UVB protection: prevents sunburn caused by short-wave UV rays. UVA protection: prevents photoaging and deep skin damage caused by long-wave UV rays. Broad-spectrum protection: protects against both UVA and UVB rays. Chemical sunscreens may cause skin irritation or allergies. Some physical sunscreens may leave a white cast or feel heavy.

[0006] Liquid crystal emulsion systems are a special emulsification technology that utilizes liquid crystal structures to form a stable system between the emulsifier and the aqueous or oil phases, giving emulsified products better feel, moisturizing effects, and stability. Due to their high efficiency, liquid crystal emulsion systems are widely used in skincare and cosmetic products.

[0007] This invention provides a whitening and sun protection composition, a whitening sunscreen, a preparation method, and an application. Summary of the Invention

[0008] To solve the above-mentioned technical problems, the present invention provides a whitening and sun protection composition, the composition comprising: solvent, filler, sunscreen agent, moisturizer, emollient, whitening agent, emulsifier, thickener, colorant, pH adjuster, skin protectant, antioxidant, fragrance, and chelating agent.

[0009] In one embodiment of the present invention, the sunscreen agent comprises humosaside, ethylhexyl salicylate, diethylaminohydroxybenzoylhexyl benzoate, ethylhexyl triazine ketone, phenylbenzimidazole sulfonic acid, methylene bis-benzotriazolyl tetramethylbutylphenol, and bis-ethylhexyloxyphenol methoxyphenyl triazine.

[0010] In one embodiment of the present invention, the moisturizer comprises butylene glycol, glycerin, and sodium polyglutamate.

[0011] In one embodiment of the present invention, the emollient comprises polydimethylsiloxane, isododecane, C12-15 alcohol benzoate, isohexadecane, polydimethylsiloxane, polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, and dibutyl adipate.

[0012] In one embodiment of the present invention, the emulsifier comprises PEG-100 stearate, glyceryl stearate, PEG-8 glyceryl isostearate, and potassium cetyl phosphate.

[0013] In one embodiment of the present invention, the thickener comprises cetearyl alcohol and polyacrylate crosspolymer-6.

[0014] This invention provides a whitening sunscreen, the raw materials of which include the aforementioned whitening and sunscreen composition.

[0015] As one embodiment of the present invention, the whitening sunscreen cream comprises the following raw materials:

[0016] 6.5 parts of humosalidinyl salicylate, 2-5 parts of ethylhexyl salicylate, 1-5 parts of silica, 3.5 parts of diethylaminohydroxybenzoylhexyl benzoate, 1-10 parts of butanediol, 2-5 parts of ethylhexyl triazine ketone, 2-5 parts of phenylbenzimidazole sulfonic acid, 1-10 parts of a mixture of methylene bis-benzotriazolyl tetramethylbutylphenol, 1-10 parts of polydimethylsiloxane, 1-10 parts of isododecane, 1-5 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 1-10 parts of glycerin, 2-3 parts of nicotinamide, 1.2 parts of PEG-100 stearate, 1.3 parts of glyceryl stearate, 1-10 parts of C12-15 alcohol benzoate, 1-10 parts of isohexadecane, 1.2 parts of polydimethylsiloxane, polydimethylsiloxane... 1.3 parts of alkyl / vinyl polydimethylsiloxane crosspolymer, 1-10 parts of dibutyl adipate, 0.5-3 parts of cetearyl alcohol, 1-4 parts of colorant, 0.1-2 parts of PEG-8 glyceryl isostearate, 0.1-1.5 parts of potassium cetyl phosphate, 0.5 parts of sodium hydroxide, 0.24-10 parts of skin protectant, 0.05 parts of tocopheryl acetate, 0.1-0.5 parts of polyacrylate crosspolymer-6, 0.15 parts of allantoin, 0.05 parts of (daily use) fragrance, 0.1-0.5 parts of tranexamic acid, 0.02-0.05 parts of disodium EDTA, 0.01-0.5 parts of sodium polyglutamate, 0.01-0.5 parts of tetrahydromethylpyrimidine carboxylic acid, and water up to 100 parts.

[0017] As one embodiment of the present invention, the preparation method of the whitening sunscreen cream includes the following steps:

[0018] As one embodiment of the present invention, the whitening and sun protection composition is applied in the field of daily chemical products.

[0019] By adopting the above technical solution, the present invention has the following beneficial effects:

[0020] This invention provides a sunscreen with a thick, creamy texture that forms a uniform and relatively thick protective film after application, providing better protection against ultraviolet rays. It adheres strongly to the skin and is not easily removed by sweat or friction.

[0021] It forms a thin protective film on the skin without burdening it. It has good fluidity and spreadability, making it easy to apply evenly and ensuring that the sunscreen is distributed more evenly on the skin surface, providing more comprehensive protection.

[0022] The lightweight texture does not affect the adherence of subsequent foundation makeup, avoiding pilling or creasing. Detailed Implementation

[0023] This invention provides a whitening sunscreen, the raw materials of which include:

[0024] 6.5 parts of humosalidinyl salicylate, 2-5 parts of ethylhexyl salicylate, 1-5 parts of silica, 3.5 parts of diethylaminohydroxybenzoylhexyl benzoate, 1-10 parts of butanediol, 2-5 parts of ethylhexyl triazine ketone, 2-5 parts of phenylbenzimidazole sulfonic acid, 1-10 parts of a mixture of methylene bis-benzotriazolyl tetramethylbutylphenol, 1-10 parts of polydimethylsiloxane, 1-10 parts of isododecane, 1-5 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 1-10 parts of glycerin, 2-3 parts of nicotinamide, 1.2 parts of PEG-100 stearate, 1.3 parts of glyceryl stearate, 1-10 parts of C12-15 alcohol benzoate, 1-10 parts of isohexadecane, 1.2 parts of polydimethylsiloxane, polydimethylsiloxane... 1.3 parts of alkyl / vinyl polydimethylsiloxane crosspolymer, 1-10 parts of dibutyl adipate, 0.5-3 parts of cetearyl alcohol, 1-4 parts of colorant, 0.1-2 parts of PEG-8 glyceryl isostearate, 0.1-1.5 parts of potassium cetyl phosphate, 0.5 parts of sodium hydroxide, 0.24-10 parts of skin protectant, 0.05 parts of tocopheryl acetate, 0.1-0.5 parts of polyacrylate crosspolymer-6, 0.15 parts of allantoin, 0.05 parts of (daily use) fragrance, 0.1-0.5 parts of tranexamic acid, 0.02-0.05 parts of disodium EDTA, 0.01-0.5 parts of sodium polyglutamate, 0.01-0.5 parts of tetrahydromethylpyrimidine carboxylic acid, and water up to 100 parts.

[0025] As one embodiment of the present invention, the whitening sunscreen is prepared by means of:

[0026] 6.5 parts of humosalidinyl salicylate, 2.5 parts of ethylhexyl salicylate, 3.5 parts of silica, 3.5 parts of diethylaminohydroxybenzoylhexyl benzoate, 8.2 parts of butanediol, 3.1 parts of ethylhexyl triazine ketone, 2.6 parts of phenylbenzimidazole sulfonic acid, 8 parts of a mixture of methylene bis-benzotriazolyl tetramethylbutylphenol, 5.5 parts of polydimethylsiloxane, 4.5 parts of isododecane, 2.2 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 4.5 parts of glycerin, 2.5 parts of nicotinamide, 1.2 parts of PEG-100 stearate, 1.3 parts of glyceryl stearate, 8.5 parts of C12-15 alcohol benzoate, 2.5 parts of isohexadecane, polydimethylsiloxane... 1.2 parts of oxane, 1.3 parts of polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 3.6 parts of dibutyl adipate, 2.4 parts of cetearyl alcohol, 3.2 parts of colorant, 1.1 parts of PEG-8 glyceryl isostearate, 0.9 parts of potassium cetyl phosphate, 0.5 parts of sodium hydroxide, 8 parts of skin protectant, 0.05 parts of tocopheryl acetate, 0.3 parts of polyacrylate crosspolymer-6, 0.15 parts of allantoin, 0.05 parts of (daily use) fragrance, 0.35 parts of tranexamic acid, 0.03 parts of disodium EDTA, 0.27 parts of sodium polyglutamate, 0.19 parts of tetrahydromethylpyrimidine carboxylic acid, and water up to 100 parts.

[0027] The methylene bis-benzotriazolyltetramethylbutylphenol mixture comprises methylene bis-benzotriazolyltetramethylbutylphenol, water, decyl glucoside, butanediol, and xanthan gum in a mass ratio of 1:2:0.5:1:0.5.

[0028] The colorant comprises: CI 77891 (titanium dioxide), CI 77491 (iron oxide red), triethoxyoctylsilane, and aluminum hydroxide, in a mass ratio of 2:0.018:2:0.5.

[0029] The skin protectant comprises: oat kernel extract, gentian root extract, sodium carboxymethyl beta-glucan, phenoxyethanol, ethylhexylglycerin, glyceryl polymethyl methacrylate, desert verbena leaf extract, silk amino acids, bifida ferment lysate, and tetrahydromethylpyrimidine carboxylic acid; and the mass ratio is 1:1:0.02:0.02:0.03:0.01:0.5:0.01:0.05:0.02.

[0030] Among them: the preparation method of oat kernel extract.

[0031] (1) Wash the oat kernels to remove surface impurities. Roast the cooked oat kernels at 100℃ for 15-20 minutes to kill surface microorganisms and soften the tissue for fermentation. Then grind the oat kernels into granules or coarse powder.

[0032] (2) Mix 40 parts oat kernel powder, 70 parts water, 5 parts glucose, 0.5 parts yeast extract, 2.0 g triammonium citrate, 2.0 g K2HPO4, 0.2 g MgSO4·7H2O, 0.05 g MnSO4·H2O, and 1.0 g Tween 80, then add 1.2 parts Lactobacillus plantarum. 24936), fermented at 37℃ for 48 hours. After fermentation, sterilized by high-temperature treatment (80℃, 10 minutes) to terminate microbial activity. Separate the solid and liquid components, and collect the fermentation broth for subsequent extraction.

[0033] (3) Filter the fermentation broth through a membrane (0.45μm filter membrane) and collect the filtrate.

[0034] Preparation method of gentian (Gentiana scabra) root extract

[0035] (1) Select dry, mold-free, and impurity-free gentian roots, slice or crush them (particle size about 1-3 mm); dry them at 50-60℃ to constant weight to reduce moisture interference in the subsequent extraction process.

[0036] (2) Water extraction was used at a material-to-liquid ratio of 1:10; the extraction was carried out at 80°C for 2-3 hours; the extract was then collected by filtration.

[0037] (3) The extract is obtained by removing particulate matter and microorganisms using a 0.2 μm filter membrane.

[0038] Preparation method of the extract of Abronia villosum leaves from desert sandy areas

[0039] S01 Select fresh desert verbena leaves collected in a pollution-free environment (keeping the leaves intact). Rinse the leaves with distilled water to remove dust and impurities. Dry at 40-50℃ to avoid damaging the active ingredients with high temperatures. Crush the dried leaves into coarse powder (0.5-2mm particle size).

[0040] S02: Leaf powder and solvent were mixed at a ratio of 1:10 (w / v). The solvent was a combination of water and ethanol (70:30). The mixture was treated with ultrasound at 40 kHz for 30 minutes, with the extraction temperature maintained at 30-50℃. The extract was filtered, and the extraction was repeated 3 times.

[0041] The SO3 extract is concentrated under vacuum at a temperature below 50°C to 1 / 4 of its original volume, retaining the active ingredients, and thus the product is obtained.

[0042] This invention provides a whitening and skin-correcting sunscreen in the form of a cream. To achieve a high SPF, a complex sunscreen agent is added, which can result in a slightly oily feel. To avoid this oiliness and excessive application, this invention uses a liquid crystal emulsification system to prepare the sunscreen. The molecular arrangement of this system is similar to the structure of the skin's stratum corneum, better mimicking the skin barrier function, helping to retain moisture and reduce water loss. Simultaneously, the structure is more stable, reducing the risk of emulsion separation, demulsification, and spoilage. The prepared sunscreen also has a silky feel, is easy to spread, non-sticky, and has a lighter, thinner texture.

[0043] However, the preparation of liquid crystal emulsion systems requires high-quality formulations. The inventors discovered that plant extracts, emulsifiers, and oil phase components in the formulation have a significant impact on the liquid crystal emulsion system. For example, the active ingredients in the extracts may exhibit strong polarity or weak hydrophobicity, potentially competing with emulsifiers and oil phases, thus interfering with the arrangement of the liquid crystal structure. Furthermore, emulsifiers containing long-chain fatty acids or alcohols are more likely to form ordered liquid crystal structures because their molecular chains can arrange themselves into regular layers or columns.

[0044] To this end, the inventors researched plant extracts and simultaneously adjusted the emulsifiers, selecting glyceryl stearate, whose long-chain fatty acid portion can form a regular layered arrangement, similar to the structure of skin lipids, enhancing the biomimetic properties of the sunscreen. PEG-8 glyceryl isostearate was chosen, which enhances water solubility, reduces the heaviness of the emulsion, and makes the liquid crystal system feel lighter. PEG-100 stearate can assist in the emulsification of the oil and water phases to form a liquid crystal layered structure. Potassium cetyl phosphate can combine with fatty alcohols and nonionic emulsifiers to stabilize the liquid crystal phase structure and prevent its decomposition during storage. Simultaneously, its phosphate structure forms a uniform protective film on the skin surface, improving the water resistance and adhesion of the liquid crystal system.

[0045] The present invention will be further explained below with reference to specific embodiments.

[0046] Example 1

[0047] This embodiment provides a whitening sunscreen, the raw materials of which include:

[0048] 6.5 parts of humosalidinyl salicylate, 2.5 parts of ethylhexyl salicylate, 3.5 parts of silica, 3.5 parts of diethylaminohydroxybenzoylhexyl benzoate, 8.2 parts of butanediol, 3.1 parts of ethylhexyl triazine ketone, 2.6 parts of phenylbenzimidazole sulfonic acid, 8 parts of a mixture of methylene bis-benzotriazolyl tetramethylbutylphenol, 5.5 parts of polydimethylsiloxane, 4.5 parts of isododecane, 2.2 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 4.5 parts of glycerin, 2.5 parts of nicotinamide, 1.2 parts of PEG-100 stearate, 1.3 parts of glyceryl stearate, 8.5 parts of C12-15 alcohol benzoate, 2.5 parts of isohexadecane, polydimethylsiloxane... 1.2 parts of oxane, 1.3 parts of polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 3.6 parts of dibutyl adipate, 2.4 parts of cetearyl alcohol, 3.2 parts of colorant, 1.1 parts of PEG-8 glyceryl isostearate, 0.9 parts of potassium cetyl phosphate, 0.5 parts of sodium hydroxide, 8 parts of skin protectant, 0.05 parts of tocopheryl acetate, 0.3 parts of polyacrylate crosspolymer-6, 0.15 parts of allantoin, 0.05 parts of (daily use) fragrance, 0.35 parts of tranexamic acid, 0.03 parts of disodium EDTA, 0.27 parts of sodium polyglutamate, 0.19 parts of tetrahydromethylpyrimidine carboxylic acid, and water up to 100 parts.

[0049] The methylene bis-benzotriazolyltetramethylbutylphenol mixture comprises methylene bis-benzotriazolyltetramethylbutylphenol, water, decyl glucoside, butanediol, and xanthan gum in a mass ratio of 1:2:0.5:1:0.5.

[0050] The colorant comprises: CI 77891 (titanium dioxide), CI 77491 (iron oxide red), triethoxyoctylsilane, and aluminum hydroxide, in a mass ratio of 2:0.018:2:0.5.

[0051] The skin protectant comprises: oat kernel extract, gentian root extract, sodium carboxymethyl beta-glucan, phenoxyethanol, ethylhexylglycerin, glyceryl polymethyl methacrylate, desert verbena leaf extract, silk amino acids, bifida ferment lysate, and tetrahydromethylpyrimidine carboxylic acid; and the mass ratio is 1:1:0.02:0.02:0.03:0.01:0.5:0.01:0.05:0.02.

[0052] Among them: the preparation method of oat (AVENA SATIVA) kernel extract

[0053] (1) Wash the oat kernels to remove surface impurities. Roast the cooked oat kernels at 100℃ for 15-20 minutes to kill surface microorganisms and soften the tissue for fermentation. Then grind the oat kernels into granules or coarse powder.

[0054] (2) Mix 40 parts oat kernel powder, 70 parts water, 5 parts glucose, 0.5 parts yeast extract, 2.0 g triammonium citrate, 2.0 g K2HPO4, 0.2 g MgSO4·7H2O, 0.05 g MnSO4·H2O, and 1.0 g Tween 80, then add 1.2 parts Lactobacillus plantarum. 24936), fermented at 37℃ for 48 hours. After fermentation, sterilized by high-temperature treatment (80℃, 10 minutes) to terminate microbial activity. Separate the solid and liquid components, and collect the fermentation broth for subsequent extraction.

[0055] (3) Filter the fermentation broth through a membrane (0.45μm filter membrane) and collect the filtrate.

[0056] Preparation method of Gentiana scabra root extract

[0057] (1) Select dry, mold-free, and impurity-free gentian roots, slice or crush them (particle size about 1-3 mm); dry them at 50-60℃ to constant weight to reduce moisture interference in the subsequent extraction process.

[0058] (2) Water extraction was used at a material-to-liquid ratio of 1:10; the extraction was carried out at 80°C for 2-3 hours; the extract was then collected by filtration.

[0059] (3) The extract is obtained by removing particulate matter and microorganisms using a 0.2 μm filter membrane.

[0060] Preparation method of the extract of Abronia villosum leaves from desert sandy areas

[0061] S01 Select fresh desert verbena leaves collected in a pollution-free environment (keeping the leaves intact). Rinse the leaves with distilled water to remove dust and impurities. Dry at 40-50℃ to avoid damaging the active ingredients with high temperatures. Crush the dried leaves into coarse powder (0.5-2mm particle size).

[0062] S02: Leaf powder and solvent were mixed at a ratio of 1:10 (w / v). The solvent was a combination of water and ethanol (70:30). The mixture was treated with ultrasound at 40 kHz for 30 minutes, with the extraction temperature maintained at 30-50℃. The extract was filtered, and the extraction was repeated 3 times.

[0063] The SO3 extract is concentrated under vacuum at a temperature below 50°C to 1 / 4 of its original volume, retaining the active ingredients, and thus the product is obtained.

[0064] The silica is a mixture of fumed silica and spherical silica in a mass ratio of 2:3; the fumed silica is HB-151 from Hubei Huifu Nanomaterials Co., Ltd.; the spherical silica is ML-SiO2-N100 from Zhejiang Manli Nanotechnology Co., Ltd.

[0065] In this embodiment, the preparation method of the whitening sunscreen agent is as follows:

[0066] (1) Accurately weigh all the ingredients in the formula and store them in clean and sterilized containers;

[0067] (2) Soak the raw materials of group A until they are uniform beforehand and set aside; disperse the raw materials of groups B and C evenly beforehand and set aside.

[0068] (3) Set the temperature of the aqueous phase tank to 85℃, add the raw materials of group D into the aqueous phase tank, stir until dissolved evenly, and keep warm for 10 minutes.

[0069] (4) Set the oil phase tank temperature to 85℃, add the E group raw material to the oil phase tank, stir until it is evenly dissolved, then add the C phase raw material, stir evenly, and keep warm for 5 minutes.

[0070] (5) Set the emulsification tank temperature to 85℃, add raw materials from groups A and B, and pump some raw materials from the aqueous phase tank into the emulsification tank. Stir and homogenize for 7 minutes until completely dispersed and uniform.

[0071] (6) Pump the raw materials from the oil phase tank and the remaining raw materials from the water phase tank into the emulsification tank, homogenize for 7 minutes, vacuum, keep warm for 10 minutes, and then start cooling.

[0072] (7) Cool down to about 55℃, add F group raw materials, stir and homogenize for 4 minutes until completely dispersed and evenly added G group raw materials; stop homogenization, vacuum defoaming, and stir for 7 minutes;

[0073] (8) When the temperature drops to 42°C, take samples for testing, transfer the material, and fill at room temperature.

[0074] in:

[0075] Group A: 1 / 3 water, polyacrylate cross-linked polymer-6;

[0076] Group B: 1 / 3 water, phenylbenzimidazole sulfonic acid, sodium hydroxide;

[0077] Group C: Polydimethylsiloxane, C12-15 alcohol benzoate, dibutyl adipate, colorant;

[0078] Group D: 1 / 3 water, butanediol, glycerin, potassium cetyl phosphate, allantoin, disodium EDTA, sodium polyglutamate;

[0079] Group E: Homosalate, Ethylhexyl salicylate, Diethylaminohydroxybenzoyl benzoate, Ethylhexyl triazine, Isododecane, Bis-ethylhexyloxyphenol methoxyphenyl triazine, PEG-100 stearate, Glyceryl stearate, Isohexadecane, Polydimethylsiloxane, Polydimethylsiloxane / Vinyl polydimethylsiloxane crosspolymer, Cetearyl alcohol, PEG-8 glyceryl isostearate;

[0080] Group F: Silica;

[0081] Group G: Remaining raw materials.

[0082] Example 2

[0083] This embodiment provides a whitening sunscreen, the raw materials of which include:

[0084] 6.5 parts of humosalidinyl salicylate, 2.5 parts of ethylhexyl salicylate, 3.5 parts of silica, 3.5 parts of diethylaminohydroxybenzoylhexyl benzoate, 8.2 parts of butanediol, 3.1 parts of ethylhexyl triazine, 2.6 parts of phenylbenzimidazole sulfonic acid, 8 parts of a mixture of methylene bis-benzotriazolyl tetramethylbutylphenol, 5.5 parts of polydimethylsiloxane, 4.5 parts of isododecane, 2.2 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 4.5 parts of glycerin, 2.5 parts of nicotinamide, and 20 parts of polysorbate. 1.2 parts, glyceryl stearate 1.3 parts, C12-15 benzoate 8.5 parts, isohexadecane 2.5 parts, polydimethylsiloxane 1.2 parts, polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer 1.3 parts, dibutyl adipate 3.6 parts, cetyl alcohol 2.4 parts, colorant 3.2 parts, PEG-8 laurate 1.1 parts, cetyl phosphate potassium 0.9 parts, sodium hydroxide 0.5 parts, skin protectant 8 parts, tocopheryl acetate 0.05 parts, polyacrylate crosspolymer-6 0.3 parts, allantoin 0.15 parts, (daily use) fragrance 0.05 parts, tranexamic acid 0.35 parts, disodium EDTA 0.03 parts, sodium polyglutamate 0.27 parts, tetrahydromethylpyrimidine carboxylic acid 0.19 parts, water up to 100 parts.

[0085] The methylene bis-benzotriazolyltetramethylbutylphenol mixture comprises methylene bis-benzotriazolyltetramethylbutylphenol, water, decyl glucoside, butanediol, and xanthan gum in a mass ratio of 1:2:0.5:1:0.5.

[0086] The colorant comprises: CI 77891 (titanium dioxide), CI 77491 (iron oxide red), triethoxyoctylsilane, and aluminum hydroxide, in a mass ratio of 2:0.018:2:0.5.

[0087] The skin protectant comprises: oat kernel extract, gentian root extract, sodium carboxymethyl beta-glucan, phenoxyethanol, ethylhexylglycerin, glyceryl polymethyl methacrylate, desert verbena leaf extract, silk amino acids, bifida ferment lysate, and tetrahydromethylpyrimidine carboxylic acid; and the mass ratio is 1:1:0.02:0.02:0.03:0.01:0.5:0.01:0.05:0.02.

[0088] Among them: the preparation method of oat (AVENA SATIVA) kernel extract

[0089] (1) Wash the oat kernels to remove surface impurities. Roast the cooked oat kernels at 100℃ for 15-20 minutes to kill surface microorganisms and soften the tissue for fermentation. Then grind the oat kernels into granules or coarse powder.

[0090] (2) Mix 40 parts oat kernel powder, 70 parts water, 5 parts glucose, 0.5 parts yeast extract, 2.0 g triammonium citrate, 2.0 g K2HPO4, 0.2 g MgSO4·7H2O, 0.05 g MnSO4·H2O, and 1.0 g Tween 80, then add 1.2 parts Lactobacillus plantarum. 24936), fermented at 37℃ for 48 hours. After fermentation, sterilized by high-temperature treatment (80℃, 10 minutes) to terminate microbial activity. Separate the solid and liquid components, and collect the fermentation broth for subsequent extraction.

[0091] (3) Filter the fermentation broth through a membrane (0.45μm filter membrane) and collect the filtrate.

[0092] Preparation method of Gentiana scabra root extract

[0093] (1) Select dry, mold-free, and impurity-free gentian roots, slice or crush them (particle size about 1-3 mm); dry them at 50-60℃ to constant weight to reduce moisture interference in the subsequent extraction process.

[0094] (2) Water extraction was used at a material-to-liquid ratio of 1:10; the extraction was carried out at 80°C for 2-3 hours; the extract was then collected by filtration.

[0095] (3) The extract is obtained by removing particulate matter and microorganisms using a 0.2 μm filter membrane.

[0096] Preparation method of the extract of Abronia villosum leaves from desert sandy areas

[0097] S01 Select fresh desert verbena leaves collected in a pollution-free environment (keeping the leaves intact). Rinse the leaves with distilled water to remove dust and impurities. Dry at 40-50℃ to avoid damaging the active ingredients with high temperatures. Crush the dried leaves into coarse powder (0.5-2mm particle size).

[0098] S02: Leaf powder and solvent were mixed at a ratio of 1:10 (w / v). The solvent was a combination of water and ethanol (70:30). The mixture was treated with ultrasound at 40 kHz for 30 minutes, with the extraction temperature maintained at 30-50℃. The extract was filtered, and the extraction was repeated 3 times.

[0099] The SO3 extract is concentrated under vacuum at a temperature below 50°C to 1 / 4 of its original volume, retaining the active ingredients, and thus the product is obtained.

[0100] The silica is a mixture of fumed silica and spherical silica in a mass ratio of 2:3; the fumed silica is HB-151 from Hubei Huifu Nanomaterials Co., Ltd.; the spherical silica is ML-SiO2-N100 from Zhejiang Manli Nanotechnology Co., Ltd.

[0101] In this embodiment, the preparation method of the whitening sunscreen agent is the same as in Example 1.

[0102] Example 3

[0103] This embodiment provides a whitening sunscreen, the raw materials of which include:

[0104] 6.5 parts of humosalidinyl salicylate, 2.5 parts of ethylhexyl salicylate, 3.5 parts of silica, 3.5 parts of diethylaminohydroxybenzoylhexyl benzoate, 8.2 parts of butanediol, 3.1 parts of ethylhexyl triazine ketone, 2.6 parts of phenylbenzimidazole sulfonic acid, 8 parts of a mixture of methylene bis-benzotriazolyl tetramethylbutylphenol, 5.5 parts of polydimethylsiloxane, 4.5 parts of isododecane, 2.2 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 4.5 parts of glycerin, 2.5 parts of nicotinamide, 1.2 parts of PEG-100 stearate, 1.3 parts of glyceryl stearate, 8.5 parts of C12-15 alcohol benzoate, 2.5 parts of isohexadecane, polydimethylsiloxane... 1.2 parts of oxane, 1.3 parts of polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 3.6 parts of dibutyl adipate, 2.4 parts of cetearyl alcohol, 3.2 parts of colorant, 1.1 parts of PEG-8 glyceryl isostearate, 0.9 parts of potassium cetyl phosphate, 0.5 parts of sodium hydroxide, 8 parts of skin protectant, 0.05 parts of tocopheryl acetate, 0.3 parts of polyacrylate crosspolymer-6, 0.15 parts of allantoin, 0.05 parts of (daily use) fragrance, 0.35 parts of tranexamic acid, 0.03 parts of disodium EDTA, 0.27 parts of sodium polyglutamate, 0.19 parts of tetrahydromethylpyrimidine carboxylic acid, and water up to 100 parts.

[0105] The methylene bis-benzotriazolyltetramethylbutylphenol mixture comprises methylene bis-benzotriazolyltetramethylbutylphenol, water, decyl glucoside, butanediol, and xanthan gum in a mass ratio of 1:2:0.5:1:0.5.

[0106] The colorant comprises: CI 77891 (titanium dioxide), CI 77491 (iron oxide red), triethoxyoctylsilane, and aluminum hydroxide, in a mass ratio of 2:0.018:2:0.5.

[0107] The skin protectant comprises: oat kernel extract, gentian root extract, sodium carboxymethyl beta-glucan, phenoxyethanol, ethylhexylglycerin, glyceryl polymethyl methacrylate, desert verbena leaf extract, silk amino acids, bifida ferment lysate, and tetrahydromethylpyrimidine carboxylic acid; and the mass ratio is 1:1:0.02:0.02:0.03:0.01:0.5:0.01:0.05:0.02.

[0108] Among them: the preparation method of oat (AVENA SATIVA) kernel extract

[0109] (1) Wash the oat kernels to remove surface impurities. Roast the cooked oat kernels at 100℃ for 15-20 minutes to kill surface microorganisms and soften the tissue for fermentation. Then grind the oat kernels into granules or coarse powder.

[0110] (2) Water extraction was used with a material-to-liquid ratio of 1:10; the extraction was carried out at 80°C for 3 hours; then the extract was collected by filtration.

[0111] (3) Filter the fermentation broth through a membrane (0.45μm filter membrane) and collect the filtrate.

[0112] Preparation method of Gentiana scabra root extract

[0113] (1) Select dry, mold-free, and impurity-free gentian roots, slice or crush them (particle size about 1-3 mm); dry them at 50-60℃ to constant weight to reduce moisture interference in the subsequent extraction process.

[0114] (2) Water extraction was used at a material-to-liquid ratio of 1:10; the extraction was carried out at 80°C for 3 hours; then the extract was collected by filtration.

[0115] (3) The extract is obtained by removing particulate matter and microorganisms using a 0.2 μm filter membrane.

[0116] Preparation method of the extract of Abronia villosum leaves from desert sandy areas

[0117] S01 Select fresh desert verbena leaves collected in a pollution-free environment (keeping the leaves intact). Rinse the leaves with distilled water to remove dust and impurities. Dry at 40-50℃ to avoid damaging the active ingredients with high temperatures. Crush the dried leaves into coarse powder (0.5-2mm particle size).

[0118] S02 was extracted using water extraction at a material-to-liquid ratio of 1:10; the extraction was carried out at 80°C for 3 hours; the extract was then collected by filtration.

[0119] The SO3 extract is concentrated under vacuum at a temperature below 50°C to 1 / 4 of its original volume, retaining the active ingredients, and thus the product is obtained.

[0120] The silica is a mixture of fumed silica and spherical silica in a mass ratio of 2:3; the fumed silica is HB-151 from Hubei Huifu Nanomaterials Co., Ltd.; the spherical silica is ML-SiO2-N100 from Zhejiang Manli Nanotechnology Co., Ltd.

[0121] In this embodiment, the preparation method of the whitening sunscreen agent is the same as in Example 1.

[0122] Example 4

[0123] This embodiment provides a whitening sunscreen, the raw materials of which include:

[0124] 6.5 parts of homosalate, 2.5 parts of ethylhexyl salicylate, 3.5 parts of silica, 3.5 parts of diethylaminohydroxybenzoylhexyl benzoate, 8.2 parts of butanediol, 3.1 parts of ethylhexyl triazine, 2.6 parts of phenylbenzimidazole sulfonic acid, 8 parts of a mixture of methylene bis-benzotriazolyl tetramethylbutylphenol, 5.5 parts of polydimethylsiloxane, 4.5 parts of isododecane, 2.2 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 4.5 parts of glycerin, 2.5 parts of nicotinamide, 2.1 parts of PEG-100 stearate, 1.3 parts of glyceryl stearate, and 8.5 parts of C12-15 alcohol benzoate. 2.5 parts isohexadecane, 1.2 parts polydimethylsiloxane, 0.8 parts polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 3.6 parts dibutyl adipate, 2.0 parts cetearyl alcohol, 3.2 parts colorant, 2.1 parts PEG-8 glyceryl isostearate, 0.5 parts sodium hydroxide, 8 parts skin protectant, 0.05 parts tocopheryl acetate, 0.15 parts allantoin, 0.05 parts (daily use) fragrance, 0.35 parts tranexamic acid, 0.03 parts disodium EDTA, 0.27 parts sodium polyglutamate, 0.19 parts tetrahydromethylpyrimidine carboxylic acid, and water to 100 parts.

[0125] The methylene bis-benzotriazolyltetramethylbutylphenol mixture comprises methylene bis-benzotriazolyltetramethylbutylphenol, water, decyl glucoside, butanediol, and xanthan gum in a mass ratio of 1:2:0.5:1:0.5.

[0126] The colorant comprises: CI 77891 (titanium dioxide), CI 77491 (iron oxide red), triethoxyoctylsilane, and aluminum hydroxide, in a mass ratio of 2:0.018:2:0.5.

[0127] The skin protectant comprises: oat kernel extract, gentian root extract, sodium carboxymethyl beta-glucan, phenoxyethanol, ethylhexylglycerin, glyceryl polymethyl methacrylate, desert verbena leaf extract, silk amino acids, bifida ferment lysate, and tetrahydromethylpyrimidine carboxylic acid; and the mass ratio is 1:1:0.02:0.02:0.03:0.01:0.5:0.01:0.05:0.02.

[0128] Among them: the preparation method of oat (AVENA SATIVA) kernel extract

[0129] (1) Wash the oat kernels to remove surface impurities. Roast the cooked oat kernels at 100℃ for 15-20 minutes to kill surface microorganisms and soften the tissue for fermentation. Then grind the oat kernels into granules or coarse powder.

[0130] (2) Mix 40 parts oat kernel powder, 70 parts water, 5 parts glucose, 0.5 parts yeast extract, 2.0 g triammonium citrate, 2.0 g K2HPO4, 0.2 g MgSO4·7H2O, 0.05 g MnSO4·H2O, and 1.0 g Tween 80, then add 1.2 parts Lactobacillus plantarum. 24936), fermented at 37℃ for 48 hours. After fermentation, sterilized by high-temperature treatment (80℃, 10 minutes) to terminate microbial activity. Separate the solid and liquid components, and collect the fermentation broth for subsequent extraction.

[0131] (3) Filter the fermentation broth through a membrane (0.45μm filter membrane) and collect the filtrate.

[0132] Preparation method of Gentiana scabra root extract

[0133] (1) Select dry, mold-free, and impurity-free gentian roots, slice or crush them (particle size about 1-3 mm); dry them at 50-60℃ to constant weight to reduce moisture interference in the subsequent extraction process.

[0134] (2) Water extraction was used at a material-to-liquid ratio of 1:10; the extraction was carried out at 80°C for 2-3 hours; the extract was then collected by filtration.

[0135] (3) The extract is obtained by removing particulate matter and microorganisms using a 0.2 μm filter membrane.

[0136] Preparation method of the extract of Abronia villosum leaves from desert sandy areas

[0137] S01 Select fresh desert verbena leaves collected in a pollution-free environment (keeping the leaves intact). Rinse the leaves with distilled water to remove dust and impurities. Dry at 40-50℃ to avoid damaging the active ingredients with high temperatures. Crush the dried leaves into coarse powder (0.5-2mm particle size).

[0138] S02: Leaf powder and solvent were mixed at a ratio of 1:10 (w / v). The solvent was a combination of water and ethanol (70:30). The mixture was treated with ultrasound at 40 kHz for 30 minutes, with the extraction temperature maintained at 30-50℃. The extract was filtered, and the extraction was repeated 3 times.

[0139] The SO3 extract is concentrated under vacuum at a temperature below 50°C to 1 / 4 of its original volume, retaining the active ingredients, and thus the product is obtained.

[0140] The silica is a mixture of fumed silica and spherical silica in a mass ratio of 2:3; the fumed silica is HB-151 from Hubei Huifu Nanomaterials Co., Ltd.; the spherical silica is ML-SiO2-N100 from Zhejiang Manli Nanotechnology Co., Ltd.

[0141] In this embodiment, the preparation method of the whitening sunscreen agent is the same as in Example 1.

[0142] Example 5

[0143] This embodiment provides a whitening sunscreen, the raw materials of which include:

[0144] 6.5 parts of humosalidinyl salicylate, 2.5 parts of ethylhexyl salicylate, 3.5 parts of silica, 3.5 parts of diethylaminohydroxybenzoylhexyl benzoate, 8.2 parts of butanediol, 3.1 parts of ethylhexyl triazine, 2.6 parts of phenylbenzimidazole sulfonic acid, 8 parts of a mixture of methylene bis-benzotriazolyl tetramethylbutylphenol, 5.5 parts of polydimethylsiloxane, 4.5 parts of isododecane, 2.2 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 4.5 parts of glycerin, 2.5 parts of nicotinamide, 2.4 parts of PEG-100 stearate, 1.3 parts of glyceryl stearate, 8.5 parts of C12-15 alcohol benzoate, 2 parts of isohexadecane 0.5 parts, polydimethylsiloxane 1.2 parts, polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer 1.3 parts, dibutyl adipate 3.6 parts, cetearyl alcohol 2.2 parts, colorant 3.2 parts, potassium cetyl phosphate 0.8 parts, sodium hydroxide 0.5 parts, skin protectant 8 parts, tocopheryl acetate 0.05 parts, polyacrylate crosspolymer-6 0.5 parts, allantoin 0.15 parts, (daily use) fragrance 0.05 parts, tranexamic acid 0.35 parts, disodium EDTA 0.03 parts, sodium polyglutamate 0.27 parts, tetrahydromethylpyrimidine carboxylic acid 0.19 parts, water up to 100 parts.

[0145] The methylene bis-benzotriazolyltetramethylbutylphenol mixture comprises methylene bis-benzotriazolyltetramethylbutylphenol, water, decyl glucoside, butanediol, and xanthan gum in a mass ratio of 1:2:0.5:1:0.5.

[0146] The colorant comprises: CI 77891 (titanium dioxide), CI 77491 (iron oxide red), triethoxyoctylsilane, and aluminum hydroxide, in a mass ratio of 2:0.018:2:0.5.

[0147] The skin protectant comprises: oat kernel extract, gentian root extract, sodium carboxymethyl beta-glucan, phenoxyethanol, ethylhexylglycerin, glyceryl polymethyl methacrylate, desert verbena leaf extract, silk amino acids, bifida ferment lysate, and tetrahydromethylpyrimidine carboxylic acid; and the mass ratio is 1:1:0.02:0.02:0.03:0.01:0.5:0.01:0.05:0.02.

[0148] Among them: the preparation method of oat (AVENA SATIVA) kernel extract

[0149] (1) Wash the oat kernels to remove surface impurities. Roast the cooked oat kernels at 100℃ for 15-20 minutes to kill surface microorganisms and soften the tissue for fermentation. Then grind the oat kernels into granules or coarse powder.

[0150] (2) Mix 40 parts oat kernel powder, 70 parts water, 5 parts glucose, 0.5 parts yeast extract, 2.0 g triammonium citrate, 2.0 g K2HPO4, 0.2 g MgSO4·7H2O, 0.05 g MnSO4·H2O, and 1.0 g Tween 80, then add 1.2 parts Lactobacillus plantarum. 24936), fermented at 37℃ for 48 hours. After fermentation, sterilized by high-temperature treatment (80℃, 10 minutes) to terminate microbial activity. Separate the solid and liquid components, and collect the fermentation broth for subsequent extraction.

[0151] (3) Filter the fermentation broth through a membrane (0.45μm filter membrane) and collect the filtrate.

[0152] Preparation method of Gentiana scabra root extract

[0153] (1) Select dry, mold-free, and impurity-free gentian roots, slice or crush them (particle size about 1-3 mm); dry them at 50-60℃ to constant weight to reduce moisture interference in the subsequent extraction process.

[0154] (2) Water extraction was used at a material-to-liquid ratio of 1:10; the extraction was carried out at 80°C for 2-3 hours; the extract was then collected by filtration.

[0155] (3) The extract is obtained by removing particulate matter and microorganisms using a 0.2 μm filter membrane.

[0156] Preparation method of the extract of Abronia villosum leaves from desert sandy areas

[0157] S01 Select fresh desert verbena leaves collected in a pollution-free environment (keeping the leaves intact). Rinse the leaves with distilled water to remove dust and impurities. Dry at 40-50℃ to avoid damaging the active ingredients with high temperatures. Crush the dried leaves into coarse powder (0.5-2mm particle size).

[0158] S02: Leaf powder and solvent were mixed at a ratio of 1:10 (w / v). The solvent was a combination of water and ethanol (70:30). The mixture was treated with ultrasound at 40 kHz for 30 minutes, with the extraction temperature maintained at 30-50℃. The extract was filtered, and the extraction was repeated 3 times.

[0159] The SO3 extract is concentrated under vacuum at a temperature below 50°C to 1 / 4 of its original volume, retaining the active ingredients, and thus the product is obtained.

[0160] The silica is a mixture of fumed silica and spherical silica in a mass ratio of 2:3; the fumed silica is HB-151 from Hubei Huifu Nanomaterials Co., Ltd.; the spherical silica is ML-SiO2-N100 from Zhejiang Manli Nanotechnology Co., Ltd.

[0161] In this embodiment, the preparation method of the whitening sunscreen agent is the same as in Example 1.

[0162] Example 6

[0163] This embodiment provides a whitening sunscreen, the raw materials of which include:

[0164] 6.5 parts of humosalidinyl salicylate, 2.5 parts of ethylhexyl salicylate, 3.5 parts of silica, 3.5 parts of diethylaminohydroxybenzoylhexyl benzoate, 8.2 parts of butanediol, 3.1 parts of ethylhexyl triazine ketone, 2.6 parts of phenylbenzimidazole sulfonic acid, 8 parts of a mixture of methylene bis-benzotriazolyl tetramethylbutylphenol, 5.5 parts of polydimethylsiloxane, 4.5 parts of isododecane, 2.2 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 4.5 parts of glycerin, 2.5 parts of nicotinamide, 1.2 parts of PEG-100 stearate, 1.3 parts of glyceryl stearate, 8.5 parts of C12-15 alcohol benzoate, 2.5 parts of isohexadecane, polydimethylsiloxane... 1.2 parts of oxane, 1.3 parts of polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 3.6 parts of dibutyl adipate, 2.4 parts of cetearyl alcohol, 3.2 parts of colorant, 1.1 parts of PEG-8 glyceryl isostearate, 0.9 parts of potassium cetyl phosphate, 0.5 parts of sodium hydroxide, 8 parts of skin protectant, 0.05 parts of tocopheryl acetate, 0.3 parts of polyacrylate crosspolymer-6, 0.15 parts of allantoin, 0.05 parts of (daily use) fragrance, 0.35 parts of tranexamic acid, 0.03 parts of disodium EDTA, 0.27 parts of sodium polyglutamate, 0.19 parts of tetrahydromethylpyrimidine carboxylic acid, and water up to 100 parts.

[0165] The methylene bis-benzotriazolyltetramethylbutylphenol mixture comprises methylene bis-benzotriazolyltetramethylbutylphenol, water, decyl glucoside, butanediol, and xanthan gum in a mass ratio of 1:2:0.5:1:0.5.

[0166] The colorant comprises: CI 77891 (titanium dioxide), CI 77491 (iron oxide red), triethoxyoctylsilane, and aluminum hydroxide, in a mass ratio of 2:0.018:2:0.5.

[0167] The skin protectant comprises: oat kernel extract, gentian root extract, sodium carboxymethyl beta-glucan, phenoxyethanol, ethylhexylglycerin, glyceryl polymethyl methacrylate, desert verbena leaf extract, silk amino acids, bifida ferment lysate, and tetrahydromethylpyrimidine carboxylic acid; and the mass ratio is 1:1:0.02:0.02:0.03:0.01:0.5:0.01:0.05:0.02.

[0168] Among them: the preparation method of oat (AVENA SATIVA) kernel extract

[0169] (1) Wash the oat kernels to remove surface impurities. Roast the cooked oat kernels at 100℃ for 15-20 minutes to kill surface microorganisms and soften the tissue for fermentation. Then grind the oat kernels into granules or coarse powder.

[0170] (2) Mix 40 parts oat kernel powder, 70 parts water, 5 parts glucose, 0.5 parts yeast extract, 2.0 g triammonium citrate, 2.0 g K2HPO4, 0.2 g MgSO4·7H2O, 0.05 g MnSO4·H2O, and 1.0 g Tween 80, then add 1.2 parts Lactobacillus plantarum. 24936), fermented at 37℃ for 48 hours. After fermentation, sterilized by high-temperature treatment (80℃, 10 minutes) to terminate microbial activity. Separate the solid and liquid components, and collect the fermentation broth for subsequent extraction.

[0171] (3) Filter the fermentation broth through a membrane (0.45μm filter membrane) and collect the filtrate.

[0172] Preparation method of Gentiana scabra root extract

[0173] (1) Select dry, mold-free, and impurity-free gentian roots, slice or crush them (particle size about 1-3 mm); dry them at 50-60℃ to constant weight to reduce moisture interference in the subsequent extraction process.

[0174] (2) Water extraction was used at a material-to-liquid ratio of 1:10; the extraction was carried out at 80°C for 2-3 hours; the extract was then collected by filtration.

[0175] (3) The extract is obtained by removing particulate matter and microorganisms using a 0.2 μm filter membrane.

[0176] Preparation method of the extract of Abronia villosum leaves from desert sandy areas

[0177] S01 Select fresh desert verbena leaves collected in a pollution-free environment (keeping the leaves intact). Rinse the leaves with distilled water to remove dust and impurities. Dry at 40-50℃ to avoid damaging the active ingredients with high temperatures. Crush the dried leaves into coarse powder (0.5-2mm particle size).

[0178] S02: Leaf powder and solvent were mixed at a ratio of 1:10 (w / v). The solvent was a combination of water and ethanol (70:30). The mixture was treated with ultrasound at 40 kHz for 30 minutes, with the extraction temperature maintained at 30-50℃. The extract was filtered, and the extraction was repeated 3 times.

[0179] The SO3 extract is concentrated under vacuum at a temperature below 50°C to 1 / 4 of its original volume, retaining the active ingredients, and thus the product is obtained.

[0180] The silica is a mixture of fumed silica and spherical silica in a mass ratio of 2:3; the fumed silica is HB-151 from Hubei Huifu Nanomaterials Co., Ltd.; the spherical silica is ML-SiO2-N100 from Zhejiang Manli Nanotechnology Co., Ltd.

[0181] In this embodiment, the preparation method of the whitening sunscreen agent is as follows:

[0182] (1) Accurately weigh all the ingredients in the formula and store them in clean and sterilized containers;

[0183] (2) Soak the raw materials of group A until they are uniform beforehand and set aside; disperse the raw materials of groups B and C evenly beforehand and set aside.

[0184] (3) Set the temperature of the aqueous phase tank to 85℃, add the raw materials of group D into the aqueous phase tank, stir until dissolved evenly, and keep warm for 10 minutes.

[0185] (4) Set the oil phase tank temperature to 85℃, add the E group raw material to the oil phase tank, stir until it is evenly dissolved, then add the C phase raw material, stir evenly, and keep warm for 5 minutes.

[0186] (5) Set the emulsification tank temperature to 85℃, add raw materials from groups A and B, and pump some raw materials from the aqueous phase tank into the emulsification tank. Stir and homogenize for 7 minutes until completely dispersed and uniform.

[0187] (6) Pump the raw materials from the oil phase tank and the remaining raw materials from the water phase tank into the emulsification tank, homogenize for 7 minutes, vacuum, keep warm for 10 minutes, and then start cooling.

[0188] (7) Cool down to about 55°C, add the raw materials of group F, stir and homogenize for 4 minutes until completely dispersed and uniform; stop homogenization, vacuum defoaming, and stir for 7 minutes;

[0189] (8) When the temperature drops to 42°C, take samples for testing, transfer the material, and fill at room temperature.

[0190] in:

[0191] Group A: 1 / 3 water, polyacrylate cross-linked polymer-6;

[0192] Group B: 1 / 3 water, phenylbenzimidazole sulfonic acid, sodium hydroxide;

[0193] Group C: Polydimethylsiloxane, C12-15 alcohol benzoate, dibutyl adipate, colorant;

[0194] Group D: 1 / 3 water, butanediol, glycerin, potassium cetyl phosphate, allantoin, disodium EDTA, sodium polyglutamate;

[0195] Group E: Homosalate, Ethylhexyl salicylate, Diethylaminohydroxybenzoyl benzoate, Ethylhexyl triazine, Isododecane, Bis-ethylhexyloxyphenol methoxyphenyl triazine, PEG-100 stearate, Glyceryl stearate, Isohexadecane, Polydimethylsiloxane, Polydimethylsiloxane / Vinyl polydimethylsiloxane crosspolymer, Cetearyl alcohol, PEG-8 glyceryl isostearate;

[0196] Group F: Remaining raw materials.

[0197] Example 7

[0198] This embodiment provides a whitening sunscreen, the raw materials of which include:

[0199] 6.5 parts of humosalidinyl salicylate, 2.5 parts of ethylhexyl salicylate, 3.5 parts of silica, 3.5 parts of diethylaminohydroxybenzoylhexyl benzoate, 8.2 parts of butanediol, 3.1 parts of ethylhexyl triazine ketone, 2.6 parts of phenylbenzimidazole sulfonic acid, 8 parts of a mixture of methylene bis-benzotriazolyl tetramethylbutylphenol, 5.5 parts of polydimethylsiloxane, 4.5 parts of isododecane, 2.2 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 4.5 parts of glycerin, 2.5 parts of nicotinamide, 1.2 parts of PEG-100 stearate, 1.3 parts of glyceryl stearate, 8.5 parts of C12-15 alcohol benzoate, 2.5 parts of isohexadecane, polydimethylsiloxane... 1.2 parts of oxane, 1.3 parts of polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 3.6 parts of dibutyl adipate, 2.4 parts of cetearyl alcohol, 3.2 parts of colorant, 1.1 parts of PEG-8 glyceryl isostearate, 0.9 parts of potassium cetyl phosphate, 0.5 parts of sodium hydroxide, 8 parts of skin protectant, 0.05 parts of tocopheryl acetate, 0.3 parts of polyacrylate crosspolymer-6, 0.15 parts of allantoin, 0.05 parts of (daily use) fragrance, 0.35 parts of tranexamic acid, 0.03 parts of disodium EDTA, 0.27 parts of sodium polyglutamate, 0.19 parts of tetrahydromethylpyrimidine carboxylic acid, and water up to 100 parts.

[0200] The methylene bis-benzotriazolyltetramethylbutylphenol mixture comprises methylene bis-benzotriazolyltetramethylbutylphenol, water, decyl glucoside, butanediol, and xanthan gum in a mass ratio of 1:2:0.5:1:0.5.

[0201] The colorant comprises: CI 77891 (titanium dioxide), CI 77491 (iron oxide red), triethoxyoctylsilane, and aluminum hydroxide, in a mass ratio of 2:0.018:2:0.5.

[0202] The skin protectant comprises: oat kernel extract, gentian root extract, sodium carboxymethyl beta-glucan, phenoxyethanol, ethylhexylglycerin, glyceryl polymethyl methacrylate, desert verbena leaf extract, silk amino acids, bifida ferment lysate, and tetrahydromethylpyrimidine carboxylic acid; and the mass ratio is 1:1:0.02:0.02:0.03:0.01:0.5:0.01:0.05:0.02.

[0203] Among them: the preparation method of oat (AVENA SATIVA) kernel extract

[0204] (1) Wash the oat kernels to remove surface impurities. Roast the cooked oat kernels at 100℃ for 15-20 minutes to kill surface microorganisms and soften the tissue for fermentation. Then grind the oat kernels into granules or coarse powder.

[0205] (2) Mix 40 parts oat kernel powder, 70 parts water, 5 parts glucose, 0.5 parts yeast extract, 2.0 g triammonium citrate, 2.0 g K2HPO4, 0.2 g MgSO4·7H2O, 0.05 g MnSO4·H2O, and 1.0 g Tween 80, then add 1.2 parts Lactobacillus plantarum. 24936), fermented at 37℃ for 48 hours. After fermentation, sterilized by high-temperature treatment (80℃, 10 minutes) to terminate microbial activity. Separate the solid and liquid components, and collect the fermentation broth for subsequent extraction.

[0206] (3) Filter the fermentation broth through a membrane (0.45μm filter membrane) and collect the filtrate.

[0207] Preparation method of Gentiana scabra root extract

[0208] (1) Select dry, mold-free, and impurity-free gentian roots, slice or crush them (particle size about 1-3 mm); dry them at 50-60℃ to constant weight to reduce moisture interference in the subsequent extraction process.

[0209] (2) Water extraction was used at a material-to-liquid ratio of 1:10; the extraction was carried out at 80°C for 2-3 hours; the extract was then collected by filtration.

[0210] (3) The extract is obtained by removing particulate matter and microorganisms using a 0.2 μm filter membrane.

[0211] Preparation method of the extract of Abronia villosum leaves from desert sandy areas

[0212] S01 Select fresh desert verbena leaves collected in a pollution-free environment (keeping the leaves intact). Rinse the leaves with distilled water to remove dust and impurities. Dry at 40-50℃ to avoid damaging the active ingredients with high temperatures. Crush the dried leaves into coarse powder (0.5-2mm particle size).

[0213] S02: Leaf powder and solvent were mixed at a ratio of 1:10 (w / v). The solvent was a combination of water and ethanol (70:30). The mixture was treated with ultrasound at 40 kHz for 30 minutes, with the extraction temperature maintained at 30-50℃. The extract was filtered, and the extraction was repeated 3 times.

[0214] The SO3 extract is concentrated under vacuum at a temperature below 50°C to 1 / 4 of its original volume, retaining the active ingredients, and thus the product is obtained.

[0215] In this invention, the silica is a mixture of fumed silica and spherical silica in a mass ratio of 2:3; the fumed silica is HB-151 from Hubei Huifu Nanomaterials Co., Ltd.

[0216] In this embodiment, the preparation method of the whitening sunscreen agent is the same as in Example 1.

[0217] Performance testing

[0218] Test 1: The sunscreens prepared in Examples 1-7 were placed at 5℃, 25℃, and 40℃ for 90 days, and the product properties and color were observed. The test results are shown in Table 1.

[0219] Test 2: Thermal Cycling Experiment: The sunscreens prepared in Examples 1-7 were placed in a sealed container, ensuring complete sealing to prevent interference from external humidity or gases. The sample was placed in a constant temperature chamber set at 45°C and maintained for 12 hours. After removal, the sample was quickly transferred to a low temperature chamber at -5°C and maintained for 12 hours. This process was repeated 6 times after completing one high-low temperature cycle. After each cycle, the physical properties of the sample, such as appearance, color, odor, viscosity, layering, and particle precipitation, were examined.

[0220] Table 1. Test results of performance test 1

[0221]

[0222] Test 3: Human skin patch test

[0223] Materials and methods

[0224] 1. Test substances: Examples 1 to 7.

[0225] 2. Negative control: Blank control.

[0226] 3. Subjects: A total of 35 subjects, including 5 males and 30 females, aged 20 to 50 years, with a mean age of 28.4 ± 2.8 years, who met the subject voluntary inclusion criteria.

[0227] 4. Patch Test Method: Select qualified patch test equipment and use the closed patch test method. Place approximately 0.020 mL to 0.025 mL of the test substance in the patch test device and apply it to the flexor side of the subject's forearm with hypoallergenic adhesive tape. Remove the test substance after 24 hours. Observe the skin reaction at 0.5, 24, and 48 hours after removal and record the results according to the skin reaction grading standard in the "Cosmetic Safety Technical Specifications" (2015 edition).

[0228] Table 2 Summary of Human Skin Patch Test Results

[0229]

[0230] Test 4: SPF value determination of sunscreen cosmetics

[0231] Materials and methods

[0232] 1. Test objects: Examples 1 to 7.

[0233] 2. Reference standard: SPF value 20.1±2.4, prepared according to the standard formula of high SPF standard (P2) in the "Cosmetic Safety Technical Specifications" (2015 edition).

[0234] 3. Subjects: A total of 35 subjects, including 5 males and 30 females, aged 20 to 50 years, with a mean age of 28.4 ± 2.8 years, who met the subject voluntary inclusion criteria.

[0235] 4. Light source: Xenon arc lamp from a daylight simulator, with all performance indicators meeting the requirements of the testing specifications.

[0236] 5. Testing Method: The testing was conducted according to the specific requirements of the "Cosmetic Safety Technical Specifications" (2015 edition). Subjects were placed in a prone position, and their backs were irradiated. The minimum erythema dose (MED) of the subject's skin to ultraviolet radiation was predicted 24 hours prior to the test, and the ultraviolet radiation dose was adjusted based on the prediction result for testing the test substance. On the day of the test, a spot no less than 30cm long was first selected on the subject's back. 2 In normal skin areas, at (2.00±0.05) mg / cm² 2Apply the test substance or control evenly to the above-mentioned area, and then select the irradiation dose according to the standard requirements. Irradiation is carried out under three conditions: ① no test substance applied to the subject's skin; ② control substance applied; ③ test substance applied. Observe the experimental results after 24 hours and record the MED values ​​under each of the three conditions.

[0237] 6. SPF Value Calculation Method: The SPF value of the analyte or control for protecting a single subject is expressed by the following formula:

[0238] SPFi = MED value of protected skin / MED value of unprotected skin * 100%

[0239] Individual SPF values ​​must be accurate to one decimal place. The SPF value of the sample is the integer part of the arithmetic mean of the SPF values ​​of all subjects tested. The sampling error of the mean can be estimated by calculating the standard deviation and standard error of the data set. The 95% confidence interval (95% CI) of the mean should not exceed 17% of the mean; otherwise, the number of subjects should be increased (not exceeding 25) until the above requirement is met.

[0240] Table 3 SPF Measurement Results

[0241]

[0242]

[0243] Test 5: Determination of the UV Protection Index (PFA) of sunscreen cosmetics

[0244] 1. Test objects: Examples 1 to 7.

[0245] 2.2. Reference standard: PFA value 4.4±0.6, prepared according to the standard formula of PFA standard in the "Cosmetic Safety Technical Specifications" (2015 edition).

[0246] 3. Subjects: A total of 35 subjects, including 5 males and 30 females, aged 20 to 50 years, with a mean age of 28.4 ± 2.8 years, who met the subject voluntary inclusion criteria.

[0247] 4. Light source: Xenon arc lamp from a daylight simulator; all performance indicators meet the requirements of the testing specifications.

[0248] 5. Test Method: The test was conducted according to the specific requirements of the "Cosmetic Safety Technical Specifications" (2015 edition). The subject was placed in a prone position, and their back was irradiated. The minimum melanization potential (MPPD) of the subject's skin to ultraviolet radiation was predicted 24 hours prior to the test, and the ultraviolet radiation dose was adjusted based on the prediction result for testing the test substance. The test was first conducted by selecting a spot at least 30cm long on the subject's back. 2 For normal skin areas, administer (2.00±0.05) mg / cm².2 Apply the test substance or control evenly to the above-mentioned area; then select the UVA irradiation dose according to the standard requirements and irradiate under three conditions: ① no test substance applied to the subject's skin; ② application of control; ③ application of test substance. Observe the experimental results after 2-4 hours and record the MPPD values ​​under each of the three conditions.

[0249] 6. Calculation method of PFA value: The PFA value of the analyte or control for protecting a single subject is expressed by the following formula:

[0250] PFAi = MPPD value of protected skin / MPPD value of unprotected skin * 100%

[0251] Individual PFA values ​​must be accurate to one decimal place. Calculate the arithmetic mean of the PFA values ​​of all subjects using the tested material protection, and take the integer part as the PFA value of that sample. The sampling error of estimating the mean can be calculated by calculating the standard deviation and standard error of the data set. The 95% confidence interval (95% CI) of the mean must not exceed 17% of the mean. Increase the number of subjects until the above requirement is met, but the number should not exceed 25.

[0252] Table 4. PFA Measurement Results

[0253] Example PFA value of reference standard PFA value of the test substance Example 1 4.5 16.1 Example 2 4.6 14.2 Example 3 4.4 13.8 Example 4 4.5 14.9 Example 5 4.7 12.4 Example 6 4.6 11.9 Example 7 4.6 13.6

[0254] Test 6: The products prepared in Examples 1 to 7 were used to conduct a sunscreen questionnaire test. 35 participants were selected (5 males and 30 females), aged 20 to 50 years, with an average age of 28.4 ± 2.8 years, meeting the voluntary inclusion criteria. The questionnaire content is shown in Table 5.

[0255] Table 5. Questionnaire Contents of Subjects on Sunscreen Products

[0256]

[0257] A score of 5 indicates complete agreement, 4 indicates moderate agreement, 3 indicates both agreement and disagreement (neutral), 2 indicates moderate disagreement, and 1 indicates complete disagreement. The result is a composite score of the 35 rankings.

[0258] Table 6. Results of the questionnaire for participants who took sun protection measures

[0259] Example Question 1 Question 2 Question 3 Question 4 Question 5 Question 6 Question 7 Question 8 1 173 174 171 173 175 175 175 174 2 146 142 132 121 134 133 128 125 3 149 148 143 136 145 148 134 138 4 132 135 126 137 130 132 127 128 5 128 129 123 130 128 130 131 130 6 135 133 139 143 145 146 142 139 7 148 145 149 150 155 154 158 153

[0260] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A whitening sunscreen characterized by comprising, The raw materials for preparing the same comprise: Humulus lupulus extract 6.5 parts, ethylhexyl salicylate 2.5 parts, silica 3.5 parts, diethylamino hydroxybenzoyl hexyl benzoate 3.5 parts, butylene glycol 8.2 parts, ethylhexyl triazone 3.1 parts, phenylbenzimidazole sulfonic acid 2.6 parts, methylene bis-benzotriazolyl tetramethylbutylphenol mixture 8 parts, dimethicone 5.5 parts, isododecane 4.5 parts, bis-ethylhexyloxyphenol methoxyphenyl triazine 2.2 parts, glycerin 4.5 parts, niacinamide 2.5 parts, PEG-100 stearate 1.2 parts, glyceryl stearate 1.3 parts, C12-15 alkyl benzoate 8.5 parts, isohexadecane 2.5 parts, dimethicone 1.2 parts, dimethicone / vinyl dimethicone crosspolymer 1.3 parts, dibutyl adipate 3.6 parts, cetearyl alcohol 2.4 parts, colorant 3.2 parts, PEG-8 glyceryl isostearate 1.1 parts, potassium cetyl phosphate 0.9 parts, sodium hydroxide 0.5 parts, skin protectant 8 parts, tocopheryl acetate 0.05 parts, polyacrylate crosspolymer-6 0.3 parts, allantoin 0.15 parts, fragrance 0.05 parts, tranexamic acid 0.35 parts, disodium EDTA 0.03 parts, sodium polyglutamate 0.27 parts, tetrahydroxymethylpyrimidine carboxylic acid 0.19 parts, water to 100 parts; The methylene bis-benzotriazolyl tetramethylbutylphenol mixture comprises methylene bis-benzotriazolyl tetramethylbutylphenol, water, decyl glucoside, butylene glycol, xanthan gum, and the mass ratio is 1:2:0.5:1:0.5; The colorant comprises CI 77891 titanium dioxide, CI 77491 red iron oxide, triethoxycaprylylsilane, aluminum hydroxide, and the mass ratio is 2:0.018:2:0.5; The skin protectant comprises oat (AVENA SATIVA) kernel extract, gentiana scabra root extract, carboxymethyl beta-glucan sodium, phenoxyethanol, ethylhexylglycerin, glyceryl polymethylacrylate, abronia villosa leaf extract, silk amino acids, saccharomyces bifida ferment lysate, tetrahydroxymethylpyrimidine carboxylic acid, and the mass ratio is 1:1:0.02:0.02:0.03:0.01:0.5:0.01:0.05:0.02; The preparation method of the oat (AVENA SATIVA) kernel extract is as follows: (1) washing oat kernels to remove surface impurities; steaming and cooking the oat kernels at 100℃ for 15-20 minutes to kill surface microorganisms and soften the tissues for easy fermentation; then crushing the oat kernels into granules or coarse powder; (2) Mix oat kernel powder 40 parts, water 70 parts, glucose 5 parts, yeast extract 0.5 parts, triammonium citrate 2.0 g, K2HPO4 2.0 g, MgSO4·7H2O 0.2 g, MnSO4·H2O 0.05 g, Tween 80 1.0 g, and then add 1.2 parts of Lactobacillus plantarum CICC® 24936, and ferment at 37℃ for 48 hours; after the fermentation is completed, sterilize by high temperature 80℃ for 10 minutes to terminate the microbial activity; separate the solid and the liquid, and collect the fermentation liquor for subsequent extraction; (3) Filter the fermentation liquor through a 0.45 μm filter, and collect the filtrate; Preparation method of gentian (GENTIANA SCABRA) root extract (1) Select dry, non-moldy, and non-impure gentian roots, cut into slices or crush to a particle size of 1-3 mm; dry at 50-60℃ until constant weight to reduce water interference in the subsequent extraction process; (2) Use water extraction method, according to the solid-liquid ratio of 1:10; heat extraction at 80℃ for 2-3 hours; then filter to collect the extract (3) Use a 0.2 μm filter membrane to remove particulate matter and microorganisms from the extract, and the extract is obtained; Preparation method of the desert sand verbena (ABRONIA VILLOSA) leaf extract S01 Select fresh desert sand verbena leaves collected in a pollution-free environment; rinse the leaves with distilled water to remove dust and impurities; dry at 40-50℃ to avoid high temperature damage to active ingredients; crush the dried leaves into coarse powder with a particle size of 0.5-2 mm; S02 Mix the leaf powder with a solvent at a ratio of 1:10 w / v; the solvent is a combination of water and ethanol at a ratio of 70:30; treat under 40 kHz ultrasonic wave for 30 minutes, and keep the extraction temperature at 30-50℃; filter the extract, and repeat the extraction for 3 times; S03 Vacuum concentrate the extract below 50℃ to 1 / 4 of the original volume, and retain the active ingredients, and the extract is obtained; The silica is a compound mixture of fumed silica and spherical silica with a mass ratio of 2:3; the fumed silica is HB-151 from Hubei Hui Fu Nanometer Material Co., Ltd.; the spherical silica is ML-SiO2-N100 from Zhejiang Manli Nanometer Technology Co., Ltd.

2. The method of claim 1, wherein the whitening sunscreen is prepared by adding the whitening agent to the sunscreen composition. The steps are as follows: (1) Accurately weigh the various raw materials in the formula, and place them in clean and sterilized containers; (2) Soak the raw materials in group A to a uniform state in advance for standby use; uniformly disperse the raw materials in groups B and C in advance for standby use; (3) Set the temperature of the water phase cylinder to 85℃, add the raw materials in group D to the water phase cylinder, and stir until dissolved uniformly, and keep warm for 10 minutes; (4) Set the temperature of the oil phase cylinder to 85℃, add the raw materials in group E to the oil phase cylinder, stir until dissolved uniformly, then add the raw materials in group C, stir uniformly, and keep warm for 5 minutes; (5) Set the temperature of the emulsification cylinder to 85℃, add the raw materials in groups A and B, draw part of the raw materials in the water phase cylinder into the emulsification cylinder, and stir for 7 minutes until completely dispersed uniformly; (6) The oil phase cylinder raw materials and the remaining water phase cylinder raw materials are extracted into the emulsification cylinder, homogenized for 7 minutes, vacuumized, and after 10 minutes of heat preservation, the cooling is started; (7) The temperature is cooled to about 55°C, the F group raw materials are added, and homogenized for 4 minutes until completely dispersed and uniform. The G group raw materials are added; stop homogenization, vacuum defoaming, and stirring for 7 minutes; (8) When the temperature is cooled to 42°C, sample detection is performed, the material body is transferred, and normal temperature filling is performed; Among them: Group A: 1 / 3 water, polyacrylate cross-linked polymer-6; Group B: 1 / 3 water, phenyl benzimidazole sulfonic acid, sodium hydroxide; Group C: Polydimethylsiloxane, C12-15 alcohol benzoate, dibutyl adipate, colorant; Group D: 1 / 3 water, butylene glycol, glycerin, potassium cetyl phosphate, allantoin, disodium EDTA, sodium polyglutamate; Group E: Homosalate, ethylhexyl salicylate, diethylhydroxybenzoyl hexyl, ethylhexyl triazone, isododecane, bis-ethylhexyloxyphenol methoxyphenyl triazine, PEG-100 stearate, glyceryl stearate, isohexadecane, dimethicone, dimethicone / vinyl dimethicone crosspolymer, cetearyl alcohol, PEG-8 glyceryl isostearate; Group F: Silica; Group G: Remaining raw materials.

3. The whitening sunscreen of claim 1, wherein, Applied to the field of daily chemicals.

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