Traditional Chinese medicine for treating children chronic aplastic anemia

Abstract

The invention provides a traditional Chinese medicine for treating children chronic aplastic anemia, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine for treating children chronic aplastic anemia comprises the following components in parts by weight: 15-30 parts of astragalus membranaceus, 20-30 parts of golden cypress, 10-20 parts of angelica sinensis, 10-20 parts of prepared rehmannia root, 10-15 parts of codonopsis pilosula, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of poria cocos, 10-15 parts of fructus lycii, 10-20 parts of dandelion, 10-20 parts of mint, 10-15 parts of glossy privet fruit, 10-15 parts of eclipta alba, 10-15 parts of fructus psoraleae, 10-15 parts of semen cuscutae, 10-15 parts of caulis spatholobi and 5-10 parts of colla corii asini. , 5-10 parts of tortoise-shell glue, and 5-10 parts of licorice. The radix astragali, the radix codonopsis, the rhizoma atractylodis macrocephalae, the poria cocos and the like have the effects of tonifying qi and spleen and promoting qi and blood biochemical sources; chinese angelica, prepared rehmannia root, donkey-hide gelatin, caulis spatholobi and the like can enrich and nourish blood The fructus lycii, the glossy privet fruit, the herba ecliptae, the fructus psoraleae, the semen cuscutae and the like have the effects of tonifying kidney and replenishing essence, regulating the immune function of the body and improving the hematopoietic microenvironment, so that the chronic aplastic anemia of children is effectively treated, and the levels of hemoglobin, leukocytes, platelets and other blood cells are improved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine for treating children with chronic aplastic anemia. Background Art

[0002] Aplastic anemia is a bone marrow hematopoietic failure syndrome, mainly characterized by a reduction in bone marrow hematopoietic cells and pancytopenia in the peripheral blood. Children with chronic aplastic anemia have a slow onset. In the early stage, anemia and bleeding are often the initial and main manifestations. The bleeding is mostly limited to the skin and mucous membranes and is not severe. Infection may occur, but it is often mainly in the respiratory tract and is easy to control.

[0003] Currently, the methods for treating children with chronic aplastic anemia in Western medicine mainly include immunosuppressive therapy, hematopoietic stem cell transplantation, etc. However, these treatment methods have certain limitations and side effects. Even if effective, some patients may relapse and require long-term or repeated treatment. Moreover, immunosuppression will increase the probability of infection, especially fungal and viral infections. Traditional Chinese medicine has unique advantages in treating children with chronic aplastic anemia. Traditional Chinese medicine can regulate the body function as a whole, improve the hematopoietic microenvironment, promote the proliferation and differentiation of hematopoietic stem cells, and has relatively few side effects. However, the existing traditional Chinese medicine formulas for treating children with chronic aplastic anemia still have problems such as insufficient efficacy and lack of strong pertinence. Therefore, it is of great clinical significance to develop a highly effective, safe and specifically targeted traditional Chinese medicine for children with chronic aplastic anemia. Summary of the Invention

[0004] (1) Technical Problems to be Solved

[0005] In view of the deficiencies of the prior art, the present invention provides a traditional Chinese medicine for treating children with chronic aplastic anemia, and solves the problems raised in the above background art.

[0006] (2) Technical Solutions

[0007] To achieve the above object, the present invention is achieved through the following technical solutions: A traditional Chinese medicine for treating children with chronic aplastic anemia, the traditional Chinese medicine comprising the following components in parts by weight: 15 - 30 parts of Astragalus membranaceus, 20 - 30 parts of Phellodendron amurense, 10 - 20 parts of Angelica sinensis, 10 - 20 parts of Rehmannia glutinosa preparata, 10 - 15 parts of Codonopsis pilosula, 10 - 15 parts of Atractylodes macrocephala, 10 - 15 parts of Poria cocos, 10 - 15 parts of Lycium barbarum, 10 - 20 parts of Taraxacum mongolicum, 10 - 20 parts of Mentha haplocalyx, 10 - 15 parts of Ligustrum lucidum, 10 - 15 parts of Eclipta prostrata, 10 - 15 parts of Psoralea corylifolia, 10 - 15 parts of Cuscuta chinensis, 10 - 15 parts of Spatholobus suberectus, 5 - 10 parts of Colla Corii Asini, 5 - 10 parts of Colla Plastri Testudinis, 5 - 10 parts of Glycyrrhiza uralensis.

[0008] Preferably, the traditional Chinese medicine comprises the following components in parts by weight: 25 parts of Astragalus membranaceus, 25 parts of Phellodendron amurense, 15 parts of Angelica sinensis, 15 parts of Rehmannia glutinosa, 13 parts of Codonopsis pilosula, 13 parts of Atractylodes macrocephala, 13 parts of Poria cocos, 13 parts of Lycium barbarum, 15 parts of Taraxacum mongolicum, 15 parts of Mentha haplocalyx, 13 parts of Ligustrum lucidum, 13 parts of Eclipta prostrata, 13 parts of Psoralea corylifolia, 13 parts of Cuscuta chinensis, 13 parts of Spatholobus suberectus, 8 parts of Colla Corii Asini, 8 parts of Colla Plastri Testudinis, and 8 parts of Glycyrrhiza uralensis.

[0009] Astragalus membranaceus: The dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. of the Leguminosae family; it can enhance myocardial contractility, protect the cardiovascular system, anti-arrhythmia, dilate the coronary artery and peripheral blood vessels, reduce blood pressure, reduce platelet adhesiveness, thus reducing thrombus formation to a certain extent and reducing platelet consumption. In addition, it also has effects such as reducing blood lipid, anti-aging, anti-hypoxia, anti-radiation, and liver protection.

[0010] Phellodendron amurense: The dried bark of Phellodendron chinense Schneid. or Phellodendron amurense Rupr. of the Rutaceae family. The former is commonly known as "Sichuan Phellodendron amurense", and the latter is commonly known as "Guan Phellodendron amurense". It can be used as medicine, with a bitter and cold nature, and has the effects of clearing heat and drying dampness, purging fire and removing steaming, and detoxifying and treating sores. It can inhibit inflammatory factors, reduce bone marrow inflammation, and promote the proliferation of hematopoietic stem cells by improving the bone marrow microenvironment.

[0011] Angelica sinensis: Aliases include Drynaria fortunei, Qinna, Western Angelica sinensis, Min Angelica sinensis, Golden Angelica sinensis, Angelica sinensis body, Han Angelica sinensis tail, Angelica sinensis curve, and Native Angelica sinensis, a perennial herb; its root is used as medicine; it has the effects of enriching blood and promoting blood circulation, regulating menstruation and relieving pain; it can harmonize blood and enrich blood, break up stagnant blood and nourish new blood, promote the production of hemoglobin and red blood cells, and promote bone marrow hematopoiesis.

[0012] Rehmannia glutinosa: Former name: Rehmannia glutinosa, also known as: Huaiqing Rehmannia glutinosa, Rehmannia glutinosa; it enriches blood and nourishes yin, supplements essence and marrow. It is mainly used for treating liver and kidney yin deficiency, soreness and weakness of the waist and knees, bone steaming and feverish sensation, night sweats and spermatorrhea, internal heat and polydipsia, blood deficiency and sallow complexion, palpitation and anxiety, irregular menstruation, metrorrhagia and metrostaxis, dizziness and tinnitus, and premature whitening of hair.

[0013] Codonopsis pilosula: Belonging to the genus Codonopsis of the Campanulaceae family, a perennial herb with latex; it enriches blood and promotes blood circulation, improves blood circulation, and alleviates anemia.

[0014] Atractylodes macrocephala: A perennial herb of the genus Atractylodes of the Asteraceae family, up to 60 cm tall, with a nodular rhizome; it has functions such as strengthening the spleen and stomach, drying dampness and promoting diuresis, stopping sweating and preventing abortion. It improves the function of the spleen and stomach, promotes the generation of qi and blood, and enhances the hematopoietic function of the body.

[0015] Poria cocos: It can prevent gastric ulcers, has a preventive and therapeutic effect on liver damage; has an anti-cancer effect; and can increase the heart rate. Pharmacological experiments show that it has diuretic and antibacterial effects, can improve the immune ability of the body. In addition, it also has effects such as reducing blood sugar, reducing gastric acid, and enhancing the contraction of the isolated heart. By strengthening the spleen, it improves the bone marrow microenvironment and promotes the proliferation of hematopoietic stem cells.

[0016] Wolfberry: Used for liver and kidney deficiency, insufficient essence and blood, soreness and weakness of the waist and knees, dizziness and tinnitus, spermatorrhea, infertility; kidney deficiency and essence deficiency, excessive thirst and dry mouth, frequent urination, red tongue; essence and blood cannot nourish the eyes, resulting in blurred vision and decreased eyesight.

[0017] Dandelion: A perennial herbaceous plant of the Compositae family and the Taraxacum genus; clearing heat and detoxifying, dissipating swelling and nodules, and assisting in regulating immune function. It exerts its effects through mechanisms such as clearing heat and detoxifying, immune regulation, and promoting hematopoiesis.

[0018] Peppermint: One of the commonly used traditional Chinese medicines in China. It is a pungent and cool diaphoretic antipyretic, treating influenza, headache, red eyes, fever, throat, and gum swelling and pain. Topically, it can treat neuralgia, skin itching, rashes, and eczema. It regulates immune function and reduces immune-mediated bone marrow damage.

[0019] Glossy Privet Fruit: A traditional Chinese medicine name. This product is the fruit of the Glossy Privet plant of the Oleaceae family. It is picked when the fruit is ripe in winter, the branches and leaves are removed and dried in the sun, or the fruit is slightly smoked and then dried in the sun; or scalded in hot water and then dried in the sun; nourishing the liver and kidney, improving eyesight and blackening hair, and enhancing immunity.

[0020] Eclipta Prostrata: Clearing heat and detoxifying, cooling blood and stopping bleeding, and assisting in regulating immune function.

[0021] Psoralea Corylifolia: The fruit is used as medicine, with the functions of tonifying the kidney and strengthening yang, invigorating the spleen and stomach, and can treat skin diseases such as psoriasis; tonifying the kidney and strengthening yang, strengthening muscles and bones, and promoting bone marrow hematopoiesis.

[0022] Cuscuta Chinensis: A good medicine for tonifying the kidney, liver, and spleen. Clinically, it is mainly used for kidney yin and yang deficiency syndromes such as kidney deficiency low back pain, impotence and spermatorrhea, frequent urination, cold uterus infertility, dim vision and loose stools; tonifying kidney and nourishing essence, nourishing the liver and improving eyesight, and enhancing immunity.

[0023] Millettia Reticulata: Another name for various plants such as the Fabaceae family, Angiospermae, Dicotyledoneae, and Papilionaceae. An evergreen woody vine, hairless, with dark green new branches, and several triangular bud scales remaining at the base; enriching blood and promoting blood circulation, relaxing tendons and activating collaterals, and improving anemia symptoms.

[0024] Donkey-hide Gelatin: Enriching blood and nourishing yin, moistening dryness, and stopping bleeding. Used for sallow complexion due to blood deficiency, dizziness and palpitations, restlessness and insomnia, and dry cough due to lung dryness.

[0025] Turtle Shell Glue: Nourishing yin, nourishing blood, and stopping bleeding. Used for yin deficiency with hectic fever, night sweats, soreness and weakness of the waist and knees, sallow complexion due to blood deficiency, metrorrhagia and leukorrhea. Removing damp arthralgia, tonifying yin deficiency, nourishing kidney water, stopping bleeding, and detoxifying. Indications: Turtle meat treats damp arthralgia, wind arthralgia, bone pain, chronic cough with cold, frequent urination at night, enuresis in children, bleeding from hemorrhoids, bloody dysentery, uterine prolapse; turtle shell treats yin deficiency, consumptive fever, bone pain, unclosed fontanel in children and head sores, dysentery in women before and after childbirth, leukorrhea in women, and itching of the vulva.

[0026] Licorice: The roots and rhizomes are thick and robust. It is a tonic Chinese herbal medicine, which is very beneficial to the human body; it can harmonize various medicines, invigorate the spleen and replenish qi, and relieve the side effects of medicines.

[0027] Preferably, the preparation method of this Chinese medicine includes the following steps:

[0028] Step 1: Material collection:

[0029] Wash astragalus membranaceus, phellodendron amurense, angelica sinensis, rehmannia glutinosa, codonopsis pilosula, atractylodes macrocephala, poria cocos, wolfberry fruit, dandelion, mint, glossy privet fruit, eclipta prostrata, psoralea corylifolia, cuscutae chinensis, millettia reticulata, and licorice, and soak them in an appropriate amount of water for 30 - 60 minutes;

[0030] Step 2: Primary filtration:

[0031] Bring the soaked raw materials to a boil over high heat, then turn to low heat and decoct for 30 - 60 minutes. After completion, filter and collect the first filtrate;

[0032] Step 3: Re - filtration:

[0033] Add an appropriate amount of water to the medicinal residues again, bring to a boil over high heat first, then turn to low heat and decoct for 20 - 40 minutes, and then filter to collect the second filtrate;

[0034] Step 4: Primary concentration:

[0035] Combine the filtrates collected twice, heat for concentration, and concentrate to a clear paste with a relative density of 1.1 - 1.2;

[0036] Step 5: Re - concentration:

[0037] Melt donkey - hide gelatin and tortoise - shell gelatin, then add them to the above - mentioned clear paste, stir evenly, and continue to concentrate until a thick paste with a relative density of 1.25 - 1.35 is obtained;

[0038] Step 6: Shaping:

[0039] Add excipients to the above - mentioned thick paste to make tablets, capsules or granules.

[0040] Preferably, in Step 2 and Step 3, the temperature of the high heat is 280 - 300 °C, and the temperature of the low heat is 80 - 120 °C.

[0041] Preferably, in Step 4 and Step 5, the conditions for concentration are: under reduced pressure, the temperature is 60 - 80 °C, and the excess water is removed.

[0042] Preferably, the relative density after concentration in Step 4 and Step 5 is measured under the condition of 60 °C.

[0043] Preferably, in step six, the adjuvants include one or more of starch, dextrin, lactose, microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate.

[0044] (III) Beneficial effects

[0045] The present invention provides a traditional Chinese medicine for treating children with chronic aplastic anemia, having the following beneficial effects:

[0046] 1. Based on traditional Chinese medicine theory, the traditional Chinese medicine composition of the present invention invigorates qi and strengthens the spleen through astragalus root, codonopsis pilosula, atractylodes macrocephala, poria cocos, etc., promoting the source of qi and blood generation; nourishes blood through angelica sinensis, rehmannia glutinosa, donkey-hide gelatin, and millettia reticulata; tonifies the kidney and replenishes essence through wolfberry fruit, glossy privet fruit, eclipta prostrata, psoralea corylifolia, and cuscuta chinensis, regulating the body's immune function and improving the hematopoietic microenvironment, thereby effectively treating children with chronic aplastic anemia and increasing the levels of blood cells such as hemoglobin, white blood cells, and platelets. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] Figure 1 It is a schematic flow chart of the preparation method of the traditional Chinese medicine of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0048] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0049] Example 1:

[0050] The embodiment of the present invention provides a traditional Chinese medicine for treating children with chronic aplastic anemia, which includes the following components in parts by weight: 15 parts of astragalus root, 20 parts of phellodendron amurense, 10 parts of angelica sinensis, 10 parts of rehmannia glutinosa, 10 parts of codonopsis pilosula, 10 parts of atractylodes macrocephala, 10 parts of poria cocos, 10 parts of wolfberry fruit, 10 parts of dandelion, 10 parts of mint, 10 parts of glossy privet fruit, 10 parts of eclipta prostrata, 10 parts of psoralea corylifolia, 10 parts of cuscuta chinensis, 10 parts of millettia reticulata, 5 parts of donkey-hide gelatin, 5 parts of tortoise shell gelatin, and 5 parts of licorice root.

[0051] As Figure 1 shown, the embodiment of the present invention also provides a preparation method of the above traditional Chinese medicine, including the following steps:

[0052] Step 1: Material taking:

[0053] Wash astragalus root, phellodendron amurense, angelica sinensis, rehmannia glutinosa, codonopsis pilosula, atractylodes macrocephala, poria cocos, wolfberry fruit, dandelion, mint, glossy privet fruit, eclipta prostrata, psoralea corylifolia, cuscuta chinensis, millettia reticulata, and licorice root, and soak them in an appropriate amount of water for 30 minutes;

[0054] Step Two: Primary Filtration:

[0055] Bring the soaked raw medicinal materials to a boil over high heat, then reduce the heat to low and decoct for 30 minutes. After completion, filter and collect the first filtrate.

[0056] Step Three: Secondary Filtration:

[0057] Add an appropriate amount of water to the medicinal residues again. Bring to a boil over high heat first, then reduce the heat to low and decoct for 20 minutes. After that, filter and collect the second filtrate.

[0058] Among them, in Step Two and Step Three, the temperature of the high heat is 280 °C, and the temperature of the low heat is 80 °C.

[0059] Step Four: Primary Concentration:

[0060] Combine the filtrates collected twice, heat for concentration, and concentrate to a clear extract with a relative density of 1.1.

[0061] Step Five: Secondary Concentration:

[0062] Melt the donkey-hide gelatin and tortoise-shell gelatin, then add them to the above-mentioned clear extract, stir evenly, and continue to concentrate until a thick extract with a relative density of 1.25 is obtained.

[0063] Among them, in Step Four and Step Five, the conditions for concentration are: under reduced pressure, the temperature is 60 °C, and the excess water is removed; and the relative density after concentration is measured under the condition of 60 °C.

[0064] Step Six: Shaping:

[0065] Add excipients to the above-mentioned thick extract to make tablets. Among them, the excipients are starch, lactose, and sodium carboxymethyl starch.

[0066] Example Two:

[0067] The embodiment of the present invention provides a traditional Chinese medicine for treating children's chronic aplastic anemia. The traditional Chinese medicine includes the following components in parts by weight: 25 parts of astragalus membranaceus, 25 parts of phellodendron amurense, 15 parts of angelica sinensis, 15 parts of rehmannia glutinosa, 13 parts of codonopsis pilosula, 13 parts of atractylodes macrocephala, 13 parts of poria cocos, 13 parts of lycium barbarum, 15 parts of dandelion, 15 parts of mentha haplocalyx, 13 parts of ligustrum lucidum, 13 parts of eclipta prostrata, 13 parts of psoralea corylifolia, 13 parts of cuscuta chinensis, 13 parts of millettia reticulata, 8 parts of donkey-hide gelatin, 8 parts of tortoise-shell gelatin, and 8 parts of licorice.

[0068] As Figure 1 shown, the embodiment of the present invention also provides a preparation method of the above-mentioned traditional Chinese medicine, including the following steps:

[0069] Step One: Material Taking:

[0070] Wash the astragalus membranaceus, phellodendron amurense, angelica sinensis, rehmannia glutinosa, codonopsis pilosula, atractylodes macrocephala, poria cocos, wolfberry fruit, dandelion, mint, glossy privet fruit, eclipta prostrata, psoralea corylifolia, cuscutae semen, millettia reticulata, and licorice, and soak them in an appropriate amount of water for 45 minutes;

[0071] Step Two: Primary Filtration:

[0072] Bring the soaked raw medicinal materials to a boil over high heat, then turn to low heat and decoct for 45 minutes. After completion, filter and collect the first filtrate;

[0073] Step Three: Secondary Filtration:

[0074] Add an appropriate amount of water to the medicinal residues again, bring to a boil over high heat first, then turn to low heat and decoct for 30 minutes, and then filter to collect the second filtrate;

[0075] Among them, in Step Two and Step Three, the temperature of the high heat is 290°C, and the temperature of the low heat is 100°C;

[0076] Step Four: Primary Concentration:

[0077] Combine the filtrates collected twice, heat for concentration, and concentrate to a clear paste with a relative density of 1.2;

[0078] Step Five: Secondary Concentration:

[0079] Melt the donkey-hide gelatin and tortoise-shell gelatin, then add them to the above-mentioned clear paste, stir evenly, and continue to concentrate until a thick paste with a relative density of 1.3 is obtained;

[0080] Among them, in Step Four and Step Five, the conditions for concentration are: under reduced pressure, the temperature is 70°C, and the excess water is removed; and the relative density after concentration is measured under the condition of 60°C;

[0081] Step Six: Shaping:

[0082] Add excipients to the above-mentioned thick paste to make capsules. Among them, the excipients are dextrin, microcrystalline cellulose, and magnesium stearate.

[0083] Example Three:

[0084] The embodiment of the present invention provides a traditional Chinese medicine for treating children with chronic aplastic anemia. The traditional Chinese medicine includes the following components in parts by weight: 30 parts of astragalus membranaceus, 30 parts of phellodendron amurense, 20 parts of angelica sinensis, 20 parts of rehmannia glutinosa, 15 parts of codonopsis pilosula, 15 parts of atractylodes macrocephala, 15 parts of poria cocos, 15 parts of wolfberry fruit, 20 parts of dandelion, 20 parts of mint, 15 parts of glossy privet fruit, 15 parts of eclipta prostrata, 15 parts of psoralea corylifolia, 15 parts of cuscutae semen, 15 parts of millettia reticulata, 10 parts of donkey-hide gelatin, 10 parts of tortoise-shell gelatin, and 10 parts of licorice.

[0085] As Figure 1As shown in the figure, the embodiments of the present invention also provide a preparation method of the above traditional Chinese medicine, including the following steps:

[0086] Step 1: Material selection:

[0087] Wash astragalus membranaceus, phellodendron amurense, angelica sinensis, rehmannia glutinosa, codonopsis pilosula, atractylodes macrocephala, poria cocos, wolfberry fruit, dandelion, mint, glossy privet fruit, eclipta prostrata, psoralea corylifolia, cuscuta chinensis, millettia reticulata, and licorice, and soak them in an appropriate amount of water for 60 minutes.

[0088] Step 2: Primary filtration:

[0089] Bring the soaked raw materials to a boil over high heat, then turn to low heat and decoct for 60 minutes. After completion, filter and collect the first filtrate.

[0090] Step 3: Secondary filtration:

[0091] Add an appropriate amount of water to the medicinal residues again, bring to a boil over high heat first, then turn to low heat and decoct for 40 minutes, and then filter to collect the second filtrate.

[0092] Among them, in Step 2 and Step 3, the temperature of the high heat is 300 °C, and the temperature of the low heat is 120 °C.

[0093] Step 4: Primary concentration:

[0094] Combine the filtrates collected twice, heat for concentration, and concentrate to a clear paste with a relative density of 1.2.

[0095] Step 5: Secondary concentration:

[0096] Melt donkey-hide gelatin and tortoise-shell gelatin, then add them to the above clear paste, stir evenly, and continue to concentrate until a thick paste with a relative density of 1.35 is obtained.

[0097] Among them, in Step 4 and Step 5, the concentration conditions are: under reduced pressure, the temperature is 80 °C, and the excess water is removed; and the relative density after concentration is measured under the condition of 60 °C.

[0098] Step 6: Shaping:

[0099] Add excipients to the above thick paste to make granules. Among them, the excipients are starch, dextrin, lactose, microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate.

[0100] Experimental example:

[0101] 1. Select 80 children with chronic aplastic anemia, randomly divide them into four groups, with 20 cases in each group, namely Experimental Group 1, Experimental Group 2, Experimental Group 3, and Control Group.

[0102] 2. The first experimental group, the second experimental group, and the third experimental group were respectively administered the traditional Chinese medicines prepared in Example 1, Example 2, and Example 3 of the present invention, 10 ml each time, 3 times a day; the control group was administered the traditional Chinese medicine for treating children with chronic aplastic anemia (formula: 10 parts of ginseng, 5 parts of pilose antler, 10 parts of human placenta, 20 parts of cooked rehmannia root, 15 parts of Chinese yam, 15 parts of angelica sinensis, etc., prepared into oral liquid, and the administration method was the same as that of the experimental group). Each of the four groups took 3 months as a treatment course and was continuously treated for 2 treatment courses.

[0103] 3. Observation indicators: Before and after treatment, the hemoglobin, white blood cells, and platelet counts of the patients in the four groups were respectively detected, and the improvement of the clinical symptoms of the patients was observed.

Claims

1. A Chinese medicine for treating chronic aplastic anemia in children, characterized in that: The traditional Chinese medicine comprises the following components in parts by weight: 15-30 parts of astragalus, 20-30 parts of phellodendron, 10-20 parts of angelica, 10-20 parts of rehmannia root, 10-15 parts of codonopsis, 10-15 parts of atractylodes, 10-15 parts of tuckahoe, 10-15 parts of wolfberry, 10-20 parts of dandelion, 10-20 parts of mint, 10-15 parts of glossy privet, 10-15 parts of eclipta, 10-15 parts of psoralea corylifolia, 10-15 parts of dodder seeds, 10-15 parts of millettia reticulata, 5-10 parts of donkey-hide gelatin, 5-10 parts of tortoise shell glue and 5-10 parts of liquorice.

2. A Chinese medicine for treating chronic aplastic anemia in children according to claim 1, characterized in that: The traditional Chinese medicine comprises the following components in parts by weight: 25 parts of astragalus, 25 parts of phellodendron, 15 parts of angelica, 15 parts of rehmannia root, 13 parts of codonopsis, 13 parts of atractylodes, 13 parts of tuckahoe, 13 parts of wolfberry, 15 parts of dandelion, 15 parts of mint, 13 parts of glossy privet, 13 parts of eclipta, 13 parts of psoralea, 13 parts of dodder seed, 13 parts of millettia reticulata, 8 parts of donkey-hide gelatin, 8 parts of tortoise shell glue and 8 parts of liquorice.

3. A Chinese medicine for treating chronic aplastic anemia in children according to claim 1 or 2, characterized in that: The preparation method of the traditional Chinese medicine comprises the following steps: Step 1: Get materials: Wash astragalus, phellodendron, angelica, rehmannia root, codonopsis, atractylodes, poria, wolfberry, dandelion, mint, privet, eclipta, psoralea corylifolia, dodder seed, millettia reticulata, and licorice, and soak them in appropriate amount of water for 30-60 minutes; Step 2: Initial filtration: Boil the soaked raw materials over high heat, then turn to low heat and boil for 30-60 minutes. After boiling, filter and collect the first filtrate. Step 3: Filter again: Add appropriate amount of water to the residue again, boil over high heat, then simmer over low heat for 20-40 minutes, filter and collect the second filtrate; Step 4: Initial concentration: The filtrates collected twice were combined, heated and concentrated to a clear paste with a relative density of 1.1-1.2; Step 5: Concentrate again: Melt donkey-hide gelatin and tortoise shell glue, then add them to the above clear paste, stir evenly, and continue to concentrate until a thick paste with a relative density of 1.25-1.35 is obtained; Step 6: Molding: Add auxiliary materials to the thick paste to prepare tablets, capsules or granules.

4. A Chinese medicine for treating chronic aplastic anemia in children according to claim 3, characterized in that: In step 2 and step 3, the temperature of the high fire is 280-300°C, and the temperature of the low fire is 80-120°C.

5. A Chinese medicine for treating chronic aplastic anemia in children according to claim 3, characterized in that: In step 4 and step 5, the concentration conditions are: under reduced pressure, the temperature is 60-80° C., and excess water is removed.

6. A Chinese medicine for treating chronic aplastic anemia in children according to claim 5, characterized in that: In step 4 and step 5, the relative density after concentration is measured at 60°C.

7. A Chinese medicine for treating chronic aplastic anemia in children according to claim 3, characterized in that: In step six, the auxiliary materials include one or more of starch, dextrin, lactose, microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate.

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