Anti-wrinkle skin care composition, application thereof and anti-wrinkle cosmetic

Abstract

The invention discloses an anti-wrinkle skin care composition, application thereof and an anti-wrinkle cosmetic. The anti-wrinkle skin care composition is prepared from the following components in percentage by mass: 0.001 to 1 part of anti-wrinkle signal peptide and 0.5 to 8 parts of beta-nicotinamide mononucleotide. The anti-wrinkle signal peptide comprises one or more of snake venom-like peptide, conopeptide and arginine / lysine polypeptide. In the composition, the anti-wrinkle signal peptide and the beta-nicotinamide mononucleotide are synergistically matched, so that the composition has an excellent quick and long-acting anti-wrinkle effect. When the composition is applied to cosmetics, the anti-wrinkle effect of the cosmetics can be effectively improved.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to an anti-wrinkle skin care composition, its application, and an anti-wrinkle cosmetic. Background Art

[0002] With the improvement of people's living standards and the increasing attention to their own images, the problem of skin aging has received more and more attention. Skin aging is mainly manifested as the appearance and increase of wrinkles, skin relaxation, decreased elasticity, dull color, etc. Among them, the appearance of wrinkles is one of the most intuitive and disturbing signs of aging.

[0003] Traditional anti-wrinkle skin care products often can only achieve skin improvement in a single dimension. For example, they only focus on moisturizing to relieve skin dryness, or simply provide limited nutritional supplements, and it is difficult to fundamentally act on the complex physiological mechanism of wrinkle formation. The formation of wrinkles involves many factors, including the loss of collagen in the body, the slowdown of cell metabolism, free radical damage, repeated muscle contractions, and the imbalance of various signaling pathways in the skin as people age. Many existing anti-wrinkle ingredients have limitations in efficacy. Some ingredients can improve the skin surface in the short term, but lack long-term effectiveness; while other ingredients cannot fully exert their anti-wrinkle potential due to problems such as low penetration rate and unstable activity.

[0004] In addition, the formulations of anti-wrinkle cosmetics on the market often lack synergistic optimization, and various active ingredients do not form efficient complementarity, which not only causes waste of resources, but also is difficult to meet the urgent needs of consumers for rapid and long-lasting anti-wrinkle effects. Therefore, developing an anti-wrinkle skin care composition that can comprehensively address the wrinkle problem, has the characteristics of rapid onset and long-term maintenance, and applying it to anti-wrinkle cosmetics is of great significance for promoting the development of anti-wrinkle cosmetics. Summary of the Invention

[0005] Based on the above problems, the present invention provides an anti-wrinkle skin care composition. The anti-wrinkle skin care composition has excellent rapid and long-term anti-wrinkle effects.

[0006] To achieve the above object, the present invention adopts the following technical solutions:

[0007] In the first aspect, the present invention provides an anti-wrinkle skin care composition, comprising the following components in parts by mass: 0.001-1 part of an anti-wrinkle signal peptide and 0.5-8 parts of β-nicotinamide mononucleotide; the anti-wrinkle signal peptide includes one or more of syn-ake peptide, conotoxin peptide, and arginine / lysine polypeptide.

[0008] Optionally, the anti-wrinkle skin care composition further comprises 0.01-5 parts by mass of hydrolyzed collagen.

[0009] Second aspect, the present invention provides an application of the anti-wrinkle skin care composition of the first aspect in the preparation of anti-wrinkle cosmetics.

[0010] Optionally, the anti-wrinkle includes reducing the area of wrinkles.

[0011] Optionally, the wrinkles include at least one of nasolabial folds, forehead wrinkles, and crow's feet.

[0012] Third aspect, the present invention provides an anti-wrinkle cosmetic, comprising the anti-wrinkle skin care composition of the first aspect.

[0013] Optionally, the mass percentage of the anti-wrinkle skin care composition in the anti-wrinkle cosmetic is 0.5% - 14%.

[0014] Optionally, the anti-wrinkle cosmetic includes essence, emulsion, cream or eye cream.

[0015] Optionally, the anti-wrinkle cosmetic includes the following components in mass percentages: 0.5% - 14% of the anti-wrinkle skin care composition, 1% - 2% of preservative, and the balance of water.

[0016] Optionally, the anti-wrinkle cosmetic includes the following components in mass percentages: 0.5% - 14% of the anti-wrinkle skin care composition, 2% - 5% of glycerol, 2% - 5% of 1,3-propanediol, 0.2% - 0.4% of acrylate / C10-30 alkyl acrylate cross-linked polymer, 0.005% - 0.03% of xanthan gum, 0.01% - 0.05% of hyaluronic acid, 0.05% - 0.1% of allantoin, 0.1% - 0.5% of p-hydroxyacetophenone, 0.02% - 0.1% of L-arginine, 0.1 - 0.5% of 1,3-hexanediol, and the balance of water.

[0017] Beneficial effects

[0018] In the anti-wrinkle skin care composition of the present invention, the anti-wrinkle signal peptide and β-nicotinamide mononucleotide cooperate synergistically to enable the composition to have excellent rapid and long-lasting anti-wrinkle effects. Applying this composition to cosmetics can effectively improve the anti-wrinkle effect of the cosmetics. Description of the drawings

[0019] Figure 1 It is a comparison chart of the area of crow's feet before and after the test subject used the essence in Example 2 of the present invention.

[0020] Figure 2 It is a curve graph showing the change of the reduction rate of the area of crow's feet corresponding to the essence in Example 2 of the present invention over time. Detailed implementation manners

[0021] An embodiment of the present invention provides an anti-wrinkle skin care composition. The composition comprises the following components in parts by mass: 0.001-1 part of anti-wrinkle signal peptide and 0.5-8 parts of β-nicotinamide mononucleotide. The anti-wrinkle signal peptide includes one or more of viperin, conotoxin, and arginine / lysine polypeptide. Among them, the anti-wrinkle signal peptide and β-nicotinamide mononucleotide cooperate synergistically to enable the composition to have excellent rapid and long-lasting anti-wrinkle effects. Applying the composition to cosmetics can effectively improve the anti-wrinkle effect of cosmetics.

[0022] As an exemplary explanation, the efficacy and mechanism of action of the composition are elaborated below.

[0023] The anti-wrinkle signal peptide has a unique mechanism of action for anti-wrinkle. For example, viperin can mimic the inhibitory effect of snake venom toxin on muscle contraction. By specifically binding to relevant receptors on the muscle cell membrane, it blocks the transmission of neurotransmitters, and then, without affecting normal muscle function, effectively soothes facial muscle tension and reduces dynamic wrinkles caused by excessive muscle contraction, such as nasolabial folds, forehead wrinkles, and crow's feet. Conotoxin, due to its molecular structure, can precisely act on the signal transduction pathway in skin cells, regulate the physiological activities of cells, promote collagen synthesis, enhance skin elasticity, and provide support for anti-wrinkle at the cellular level. Arginine / lysine polypeptide has both moisturizing and anti-wrinkle dual characteristics. On the one hand, it activates the activity of fibroblasts and stimulates the secretion of matrix proteins such as collagen and elastin to fill the structural components lost by the skin due to aging; on the other hand, its good hydrophilicity enables it to firmly lock in the moisture of the skin, maintain the moist state of the skin, and jointly combat the formation of wrinkles.

[0024] β-Nicotinamide mononucleotide (NMN), a highly regarded anti-aging substance in recent years, plays a central role in cellular energy metabolism. It is a precursor substance of coenzyme I (NAD + ). After entering the cell, it can be rapidly converted into NAD + , activating a series of key enzymatic reactions in the cell, such as the activation of the sirtuins protein family involved in DNA repair. This not only helps repair damaged cell DNA, maintains the normal function and vitality of cells, and delays the process of cell aging; but also promotes mitochondrial energy generation, provides sufficient power for skin cells, enables them to maintain efficient operation in physiological activities such as metabolism and synthesis, comprehensively improves the health status of the skin, and combats wrinkles from the root cause, reducing the growth of wrinkles.

[0025] Optionally, the anti-wrinkle skin care composition further comprises 0.01-5 parts by mass of hydrolyzed collagen.

[0026] Hydrolyzed collagen is generally extracted from the bones and skins of animals that have passed health quarantine. First, it is purified by eluting the minerals in the bones and skins with food-grade dilute acid. Then, different animal skin raw materials are treated with alkali or acid. Next, high-purity reverse osmosis water is used to extract macromolecular collagen at a certain temperature. Finally, through an enzymatic hydrolysis process, the macromolecular chains are effectively cut, and efficient amino acid groups are retained to form hydrolyzed collagen with a specific molecular weight. After that, it is made into a product through processes such as multiple filtrations, removal of impurity ions, sterilization, and drying. Hydrolyzed collagen has excellent water solubility and skin affinity. Its small molecular structure can easily penetrate the stratum corneum of the skin and reach the dermis layer, directly supplementing the lost collagen fragments for the skin, quickly filling the wrinkles and depressions formed due to collagen deficiency, and achieving an immediate effect of smoothing wrinkles. At the same time, hydrolyzed collagen can also induce the proliferation of fibroblasts, stimulate them to continuously synthesize new collagen, further strengthen the supporting structure of the skin, maintain the firmness and elasticity of the skin, and achieve long-term anti-wrinkle effects.

[0027] Optionally, the anti-wrinkle signal peptide is a powder obtained by freeze-drying, β-nicotinamide mononucleotide is a powder obtained by freeze-drying, and hydrolyzed collagen is a powder obtained by freeze-drying. Freeze-dried powder can retain the biological activity of each component to a great extent, remove moisture, prevent the growth of microorganisms and the degradation of components, and ensure the stability and efficacy persistence of the composition during storage and use.

[0028] It can be understood that in the present invention, the anti-wrinkle signal peptide, β-nicotinamide mononucleotide, and hydrolyzed collagen can all be commercially available products.

[0029] As optional examples of the mass parts of each component in the anti-wrinkle skin care composition, the mass parts of the anti-wrinkle signal peptide can be 0.001 part, 0.005 part, 0.01 part, 0.05 part, 0.1 part, 0.5 part, 1 part. It can be understood that the mass parts of the anti-wrinkle signal peptide can also make other suitable selections within the range of 0.001 - 1 part.

[0030] The mass parts of β-nicotinamide mononucleotide can be 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts. It can be understood that the mass parts of β-nicotinamide mononucleotide can also make other suitable selections within the range of 0.5 - 8 parts.

[0031] The mass parts of hydrolyzed collagen can be 0.01 part, 0.05 part, 0.1 part, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts. It can be understood that the mass parts of hydrolyzed collagen can also make other suitable selections within the range of 0.01 - 5 parts.

[0032] Another embodiment of the present invention provides an application of the above anti-wrinkle skin care composition in the preparation of anti-wrinkle cosmetics. Optionally, anti-wrinkle includes reducing the area of wrinkles. Further optionally, the wrinkles include at least one of nasolabial folds, forehead wrinkles, and crow's feet. After the composition is applied to anti-wrinkle cosmetics, it can significantly reduce the area of wrinkles, and has excellent improvement effects especially on typical facial wrinkles such as nasolabial folds, forehead wrinkles, and crow's feet.

[0033] Furthermore, another embodiment of the present invention provides an anti-wrinkle cosmetic. The anti-wrinkle cosmetic includes the above anti-wrinkle skin care composition.

[0034] Optionally, the mass percentage of the anti-wrinkle skin care composition in the anti-wrinkle cosmetic is 0.5%-14%. For example, the mass percentage of the anti-wrinkle skin care composition in the anti-wrinkle cosmetic can be 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%. It can be understood that the mass percentage of the anti-wrinkle skin care composition in the anti-wrinkle cosmetic can also be other suitable choices within the range of 0.5%-14%.

[0035] Optionally, the anti-wrinkle cosmetic includes essence, emulsion, cream, or eye cream.

[0036] In some embodiments, the anti-wrinkle cosmetic includes the following components in mass percentages: 0.5%-14% of the anti-wrinkle skin care composition, 1%-2% of preservative, and the balance of water. The addition of the preservative is aimed at ensuring the microbial safety of the product during the usage period and preventing deterioration, while water serves as a solvent to provide a medium for the uniform dispersion of each component, ensuring the texture and usability of the product.

[0037] Optionally, in the anti-wrinkle cosmetic, the mass percentage of the preservative can be 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%. It can be understood that the mass percentage of the preservative can also be other suitable choices within the range of 1%-2%.

[0038] In some embodiments, the anti-wrinkle cosmetic includes the following components in mass percentages: 0.5%-14% of the anti-wrinkle skin care composition, 2%-5% of glycerol, 2%-5% of 1,3-propanediol, 0.2%-0.4% of acrylate / C10-30 alkyl acrylate cross-linked polymer, 0.005%-0.03% of xanthan gum, 0.01%-0.05% of hyaluronic acid, 0.05%-0.1% of allantoin, 0.1%-0.5% of p-hydroxyacetophenone, 0.02%-0.1% of L-arginine, 0.1-0.5% of 1,3-hexanediol, and the balance of water.

[0039] Among them, glycerin and 1,3 - propanediol can be used as humectants, synergistically playing the functions of moisture absorption and water locking, continuously moisturizing the skin, strengthening the skin barrier function, keeping the skin moist and shiny at all times, and enhancing the anti - wrinkle effect. Acrylate / C10 - 30 alkyl acrylate cross - polymer and xanthan gum can be used as thickeners to adjust the viscosity and rheological properties of the product, ensure the smoothness and extensibility during application, and improve the use experience. Hyaluronic acid can be used as a natural moisturizing factor, which can absorb and retain a large amount of water, further enhancing the skin's moisturizing ability, filling the gaps between wrinkles, and making the wrinkles look shallower. Allantoin has a soothing and anti - inflammatory effect, which can relieve the slight discomfort of the skin caused by external stimuli or the action of anti - wrinkle ingredients and promote skin repair. p - Hydroxyacetophenone and 1,3 - hexanediol can be used as mild preservatives, synergistically with other ingredients to ensure the microbial stability of the product. L - Arginine is used to adjust the pH value of the product to be within the pH range suitable for the skin, ensuring the effectiveness and stability of each ingredient.

[0040] Optionally, in the anti - wrinkle cosmetic, the mass percentage of glycerin is 2%, 3%, 4%, 5%. It is understandable that the mass percentage of glycerin in the anti - wrinkle cosmetic can also be selected as other suitable values within the range of 2% - 5%.

[0041] Optionally, in the anti - wrinkle cosmetic, the mass percentage of 1,3 - propanediol is 2%, 3%, 4%, 5%. It is understandable that the mass percentage of 1,3 - propanediol in the anti - wrinkle cosmetic can also be selected as other suitable values within the range of 2% - 5%.

[0042] Optionally, in the anti - wrinkle cosmetic, the mass percentage of acrylate / C10 - 30 alkyl acrylate cross - polymer is 0.2%, 0.25%, 0.3%, 0.35%, 0.4%. It is understandable that the mass percentage of acrylate / C10 - 30 alkyl acrylate cross - polymer in the anti - wrinkle cosmetic can also be selected as other suitable values within the range of 0.2% - 0.4%.

[0043] Optionally, in the anti - wrinkle cosmetic, the mass percentage of xanthan gum is 0.005%, 0.008%, 0.01%, 0.02%, 0.03%. It is understandable that the mass percentage of xanthan gum in the anti - wrinkle cosmetic can also be selected as other suitable values within the range of 0.005% - 0.03%.

[0044] Optionally, in the anti - wrinkle cosmetic, the mass percentage of hyaluronic acid is 0.01%, 0.02%, 0.03%, 0.04%, 0.05%. It is understandable that the mass percentage of hyaluronic acid in the anti - wrinkle cosmetic can also be selected as other suitable values within the range of 0.01% - 0.05%.

[0045] Optionally, in the anti-wrinkle cosmetic, the mass percentage of allantoin is 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%. It is understandable that other suitable selections can also be made for the mass percentage of allantoin in the anti-wrinkle cosmetic within the range of 0.05% - 0.1%.

[0046] Optionally, in the anti-wrinkle cosmetic, the mass percentage of p-hydroxyacetophenone is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%. It is understandable that other suitable selections can also be made for the mass percentage of p-hydroxyacetophenone in the anti-wrinkle cosmetic within the range of 0.1% - 0.5%.

[0047] Optionally, in the anti-wrinkle cosmetic, the mass percentage of L-arginine is 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%. It is understandable that other suitable selections can also be made for the mass percentage of L-arginine in the anti-wrinkle cosmetic within the range of 0.02% - 0.1%.

[0048] Optionally, in the anti-wrinkle cosmetic, the mass percentage of 1,3-hexanediol is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%. It is understandable that other suitable selections can also be made for the mass percentage of 1,3-hexanediol in the anti-wrinkle cosmetic within the range of 0.1 - 0.5%.

[0049] Another embodiment of the present invention provides a preparation method of the above anti-wrinkle cosmetic. The preparation method includes the following steps: mixing each component evenly and performing homogenization treatment at 50°C - 70°C, then cooling and filtering to obtain an instant anti-wrinkle cosmetic. This preparation method is simple and easy to implement, and is easy to promote.

[0050] Optionally, the temperature of the homogenization treatment can be 50°C, 55°C, 60°C, 65°C, 70°C. It is understandable that other suitable selections can also be made for the temperature of the homogenization treatment within the range of 50°C - 70°C.

[0051] In some embodiments, the time of the homogenization treatment is 5 min - 10 min. For example, the time of the homogenization treatment can be 5 min, 6 min, 7 min, 8 min, 9 min, 10 min. It is understandable that other suitable selections can also be made for the time of the homogenization treatment within the range of 5 min - 10 min.

[0052] Example 1

[0053] In this embodiment, the anti-wrinkle skin care composition is composed of the following components: 0.5 part of anti-wrinkle signal peptide and 4 parts of β-nicotinamide mononucleotide; the anti-wrinkle signal peptide is conotoxin peptide.

[0054] In this embodiment, the essence is composed of the following components in mass percentages: 5% of the anti-wrinkle skin care composition, 3% of glycerin, 3% of 1,3-propanediol, 0.25% of acrylate / C10-30 alkyl acrylate cross-linked polymer, 0.01% of xanthan gum, 0.03% of hyaluronic acid, 0.08% of allantoin, 0.3% of hydroxyacetophenone, 0.06% of L-arginine, 0.3% of 1,3-hexanediol, and the balance of water. The sum of the mass percentages of each component is 100%.

[0055] Example 2

[0056] Compared with Example 1, Example 2 is different in that the anti-wrinkle skin care composition is composed of the following components: 0.001 part of anti-wrinkle signal peptide, 0.5 part of β-nicotinamide mononucleotide, and 0.01 part of hydrolyzed collagen; the anti-wrinkle signal peptide is conotoxin peptide.

[0057] Examples 3-4, Comparative Examples 1-2

[0058] Compared with Example 2, Examples 3-4 and Comparative Examples 1-2 are different in that the weight parts of each component in the anti-wrinkle skin care composition are different, as specifically shown in Table 1.

[0059] Example 5

[0060] Compared with Example 3, Example 5 is different in that the conotoxin peptide is replaced with an equal mass part of venom-like peptide.

[0061] Example 6

[0062] Compared with Example 3, Example 6 is different in that the conotoxin peptide is replaced with an equal mass part of arginine / lysine polypeptide.

[0063] Test Example

[0064] (1) Test subjects: 30 healthy people aged 30-60, including 18 females and 12 males. The essence obtained from the examples and comparative examples was applied to the corners of the eyes on the left and right sides of the test subjects, and the change in the area of crow's feet of the test subjects over time was calculated. The average value of the reduction rate of the crow's feet area of the 30 test subjects was taken as the result of the reduction rate of the crow's feet area corresponding to the examples and comparative examples. Among them, after 5 minutes of action, the reduction rates of the crow's feet area corresponding to the examples and comparative examples are shown in Table 1. It can be seen from Table 1 that the essence in the examples has a significantly improved reduction rate of the crow's feet area compared with the comparative examples. Further, when the composition in the essence contains hydrolyzed collagen, the anti-wrinkle effect of the essence can be further improved.

[0065] Judgment: According to the condition of the crow's feet at the right eye corner of the subject before and after using the test sample photographed by the VISIA-CR facial imager, and then analyzed by the Image-Pro skin comprehensive analysis software, the improvement of the crow's feet is judged. Fishtail lines area - the area of crow's feet; Fishtail lines area / AOl area - the proportion of the crow's feet area in the selected area.

[0066] Parameter: Fishtail lines area - the area of crow's feet.

[0067]

[0068] The condition of the crow's feet of one of the test objects corresponding to the essence in Example 3 before use and after 5 minutes of use is as Figure 1 shown. Figure 1 In it, the red marked areas are the crow's feet. (a) is the skin state diagram before using the essence, and (b) is the skin state diagram after 5 minutes of using the essence. The red circled areas in the figure are the areas of the crow's feet. The area proportion of the crow's feet in (a) is 3.94%, and the area proportion of the crow's feet in (b) is 2.8%. It can be Figure 1 calculated that after using the essence in Example 1, the reduction rate of the crow's feet area is (3.94 - 2.8) / 3.94×100% = 28.93%. This shows that the essence in Example 3 has a good instant anti-wrinkle effect.

[0069] The change curve of the reduction rate of the crow's feet area corresponding to the essence in Example 3 with time is as Figure 2 shown. Figure 2 In it, the abscissa represents time, the unit is min, and the ordinate is the reduction rate of the crow's feet area, the unit is %. It can be Figure 2 seen that the essence in Example 3 has a good instant anti-wrinkle effect and can obtain a good anti-wrinkle effect in a short time.

[0070] Table 1

[0071]

[0072] (2) Perform a cytological model safety test on the composition in Example 3. The test method and results are shown in Table 2. It can be seen from Table 2 that the composition in Example 3 has good safety.

[0073] Table 2

[0074]

[0075] (3) Further test the safety of the composition according to the human skin patch test method in the "Technical Specifications for Cosmetics Safety" 2015 edition of China. Configure the composition in Example 3 into an aqueous solution with a mass percentage of 30%. Test subjects: 30 healthy people aged 30 - 60 years old, including 18 females and 12 males. The test times are 24 hours and 48 hours respectively, and the test results are shown in Table 3. It can be seen from Table 3 that no adverse reactions occurred in the test subjects after 24h and 48h. The results show that the composition still has good safety at a relatively high concentration, will not cause adverse skin reactions, and is safe and non-toxic.

[0076] Table 3

[0077]

[0078] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

[0079] For those of ordinary skill in the art, based on the idea of the present invention, there will be changes in the specific implementation manner and application scope. In summary, the content of this specification should not be construed as a limitation to the present invention.

Claims

1. An anti-wrinkle skin care composition, characterized in that, Comprising the following components in parts by mass: 0.001-1 part of anti-wrinkle signal peptide and 0.5-8 parts of β-nicotinamide mononucleotide; the anti-wrinkle signal peptide includes one or more of syneptide, conotoxin, and arginine / lysine polypeptide.

2. The anti-wrinkle skin care composition according to claim 1, characterized in that, The anti-wrinkle skin care composition further comprises 0.01-5 parts by mass of hydrolyzed collagen.

3. Use of the anti-wrinkle skin care composition according to claim 1 or 2 in the preparation of anti-wrinkle cosmetics.

4. The application according to claim 3, wherein The anti-wrinkle includes reducing the area of wrinkles.

5. The application according to claim 4, wherein The wrinkles include at least one of nasolabial folds, forehead wrinkles, and crow's feet.

6. An anti-wrinkle cosmetic, characterized in that, Comprising the anti-wrinkle skin care composition according to claim 1 or 2.

7. The anti-wrinkle cosmetic according to claim 6, wherein The mass percentage of the anti-wrinkle skin care composition in the anti-wrinkle cosmetics is 0.5%-14%.

8. The anti-wrinkle cosmetic according to claim 6, characterized in that, The anti-wrinkle cosmetics include essence, emulsion, cream or eye cream.

9. The anti-wrinkle cosmetic according to any one of claims 6-8, characterized in that, The anti-wrinkle cosmetics comprise the following components in mass percentage: The anti-wrinkle skin care composition 0.5%-14%, preservative 1%-2%, and the balance water.

10. The anti-wrinkle cosmetic according to any one of claims 6-8, characterized in that, The anti-wrinkle cosmetics comprise the following components in mass percentage: The anti-wrinkle skin care composition 0.5%-14%, glycerol 2%-5%, 1,3-propanediol 2%-5%, acrylate / C10-30 alkyl acrylate cross-linked polymer 0.2%-0.4%, xanthan gum 0.005%-0.03%, hyaluronic acid 0.01%-0.05%, allantoin 0.05%-0.1%, p-hydroxyacetophenone 0.1%-0.5%, L-arginine 0.02%-0.1%, 1,3-hexanediol 0.1-0.5%, and the balance water.

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