Immunogenic antifungal polypeptides, compositions and methods thereof

By using immunogenic peptides PF-KEX1b and PF-KEX2b and their polynucleotides, the immune response against fungal pathogens is induced, and the problem of lack of effective treatment or prevention of fungal infection in the prior art is solved, and cross-protective treatment and prevention of a variety of fungal pathogens is achieved.

CN120344254APending Publication Date: 2025-07-18UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC
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Patent Information

Application Number
CN202380080362.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2022-09-23
Filing Date
2023-09-21
Publication Date
2025-07-18

AI Technical Summary

Technical Problem

The prior art lacks effective and cost-effective methods for treating or preventing infections and related diseases caused by fungal pathogens, especially in individuals with weakened or damaged immune systems, especially in less affluent regions around the world.

Method used

The immunogenic peptides PF-KEX1b and PF-KEX2b and their encoding polynucleotides are provided to prepare cross-protective antiserum to treat or prevent related diseases by administering these peptides or polynucleotides to the subject.

Benefits of technology

Cross-protection of multiple fungal pathogen infections is achieved, reducing immune compromise or suppressing the risk of fungal infections in subjects and the severity of related diseases, providing economical and effective treatment and prevention means.

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Abstract

Immunogenic compositions comprising non-naturally occurring generic fungal kexin peptides are described and characterized and the use of such compositions in the treatment or prevention of various diseases or severe diseases and / or symptoms thereof in a subject, in particular in the treatment or prevention of various diseases or severe diseases and / or symptoms thereof, in particular in the treatment or prevention of diseases associated with fungal pathogens (e.g., fungal pathogens). The present invention relates to a method for treating diseases or severe diseases and / or symptoms thereof associated with infection by genus Pneumocystis, Aspergillus, Candida, or Cryptococcus, e.g., Aspergillus, Candida, or Cryptococcus. The immunogenic peptides or immunogenic fragments thereof may be recombinantly produced, recombined, and / or isolated.
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