Massa medicata fermentata fujianensis and processing method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to Jianqu and a processing method thereof, and the Jianqu comprises the following raw materials and auxiliary materials: polygonum hydropiper, eupatorium, artemisia apiacea, semen armeniacae amarae, phaseolus calcaratus, fructus aurantii (stir-fried with bran), betel nut powder, rhizoma cyperi powder, magnolia officinalis powder, mint powder, rice sprout powder, malt powder, cinnamon powder, perilla powder, hawthorn (stir-fried), rhizoma atractylodis, radix angelicae, pericarpium citri reticulatae, pogostemon cablin, liquorice, common vladimiria root, wheat bran and flour. According to the Jianqu disclosed by the invention, the herba eupatorii which also has the functions of relieving exterior syndrome and resolving dampness, can promote digestive juice secretion and does not contain toxicity is used for replacing xanthium sibiricum, and the formula does not contain the xanthium sibiricum with toxicity, so that the original effects of improving dyspepsia and relieving gastrointestinal discomfort can be well maintained and even improved; moreover, the injury to the liver can be well avoided, and the safety is better.

Description

Technical Field:

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly relates to a Jianqu and its processing method. Background Art:

[0002] Jianqu is a medicine used for treating headache due to cold or heat, food stagnation blocking the middle energizer, vomiting and distension. Jianqu is pungent, sweet, warm in nature and slightly bitter. It acts on the spleen and stomach meridians. It has the functions of promoting digestion and resolving food stagnation, dispersing wind-cold, strengthening the spleen and regulating the stomach, and is used for treating headache due to cold, retention of undigested food, fullness and distension in the chest and abdomen, and diarrhea due to spleen deficiency. Jianqu is a medicinal leaven prepared by natural fermentation of dozens of traditional Chinese medicines. It is a rectangular block in yellowish-brown color, with a rough outer surface, yellowish-brown, covered with white mold, and a loose cross-section; it has a delicate fragrance and a slightly bitter taste.

[0003] In the prior art, such as the Chinese invention authorization patent with the application number CN201410524963.1, most of the existing traditional Jianqu formulas generally include the following raw and auxiliary materials in the following weight ratios:

[0004] Polygonum hydropiper 3.3 - 9.9 parts, Xanthium sibiricum 3.3 - 9.9 parts, Artemisia annua 3.3 - 9.9 parts, Prunus armeniaca var. ansu 2 - 6 parts, Phaseolus angularis 2 - 6 parts, Aurantii Fructus (stir-fried with bran) 1.5 - 4.5 parts, Areca catechu 1.5 - 4.5 parts, Cyperus rotundus 3 - 9 parts, Magnolia officinalis 1.5 - 4.5 parts, Mentha haplocalyx 1.5 - 4.5 parts, Setaria italica (L.) Beauv. var. germanica (Mill.) Schred 4.5 - 13.5 parts, Hordeum vulgare L. var. nudum Hook.f. 4.5 - 13.5 parts, Cinnamomum cassia 0.75 - 2.25 parts, Perilla frutescens 3 - 9 parts, Crataegus pinnatifida (Bge.) Bge. var. major N.E.Br. (stir-fried) 4.5 - 13.5 parts, Atractylodes lancea (Thunb.) DC. 3 - 9 parts, Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana (Boiss.) Shan et Yuan 1.5 - 4.5 parts, Citrus reticulata Blanco 3 - 9 parts, Pogostemon cablin (Blanco) Benth. 3 - 9 parts, Glycyrrhiza uralensis Fisch. 0.75 - 2.25 parts, Aucklandia lappa Decne. 1.5 - 4.5 parts, wheat bran 10.6 - 31.8 parts, wheat flour 5.3 - 15.9 parts;

[0005] The instructions of the Jianqu prepared with the existing traditional formula also indicate precautions "Patients with severe chronic diseases such as heart disease, liver disease, diabetes, kidney disease, etc. should take it under the guidance of a doctor. If new severe symptoms such as chest tightness and palpitations appear, stop taking the medicine immediately and go to the hospital for treatment". A large part of the reason is related to the Xanthium sibiricum in it. Although Xanthium sibiricum has the effects of expelling wind and dampness, sweating and opening orifices, it contains toxic components such as xanthostrumarin. Long-term or excessive use may cause damage to the liver and kidneys. There is an urgent need for a Jianqu formula that can replace the existing traditional one and is safer. Summary of the Invention:

[0006] The purpose of the present invention is to provide a Jianqu in view of the deficiencies of the prior art. By replacing Xanthium sibiricum with Eupatorium fortunei Turcz. which also has the function of relieving exterior syndrome and resolving dampness, can promote the secretion of digestive juice and does not contain toxicity, the formula does not contain toxic Xanthium sibiricum. It can not only well maintain or even improve the original efficacy of improving dyspepsia and relieving gastrointestinal discomfort, but also can well avoid liver damage and has better safety.

[0007] To achieve the above object, the technical solution adopted by the present invention is: a Jianqu, including Polygonum hydropiperoides, Eupatorium fortunei, Artemisia annua, Prunus armeniaca, Phaseolus angularis, Fructus Aurantii (stir-fried with bran), Areca catechu, Cyperus rotundus, Magnolia officinalis, Mentha haplocalyx, Fructus Setariae Germinatus, Fructus Hordei Germinatus, Cinnamomum cassia, Perilla frutescens, Crataegus pinnatifida (stir-fried), Atractylodes lancea, Angelica dahurica, Citrus reticulata, Pogostemon cablin, Glycyrrhiza glabra, Aucklandia lappa, wheat bran, and flour.

[0008] A further improvement to the above solution is that it includes the following raw and auxiliary materials with weight ratios:

[0009] Polygonum hydropiperoides 3.3 - 9.9 parts, Eupatorium fortunei 3.3 - 9.9 parts, Artemisia annua 3.3 - 9.9 parts, Prunus armeniaca 2 - 6 parts, Phaseolus angularis 2 - 6 parts, Fructus Aurantii (stir-fried with bran) 1.5 - 4.5 parts, Areca catechu 1.5 - 4.5 parts, Cyperus rotundus 3 - 9 parts, Magnolia officinalis 1.5 - 4.5 parts, Mentha haplocalyx 1.5 - 4.5 parts, Fructus Setariae Germinatus 4.5 - 13.5 parts, Fructus Hordei Germinatus 4.5 - 13.5 parts, Cinnamomum cassia 0.75 - 2.25 parts, Perilla frutescens 3 - 9 parts, Crataegus pinnatifida (stir-fried) 4.5 - 13.5 parts, Atractylodes lancea 3 - 9 parts, Angelica dahurica 1.5 - 4.5 parts, Citrus reticulata 3 - 9 parts, Pogostemon cablin 3 - 9 parts, Glycyrrhiza glabra 0.75 - 2.25 parts, Aucklandia lappa 1.5 - 4.5 parts, wheat bran 10.6 - 31.8 parts, and flour 5.3 - 15.9 parts.

[0010] A further improvement to the above solution is that it includes the following raw and auxiliary materials with weight ratios:

[0011] Polygonum hydropiperoides 3.3 - 9.9 parts, Eupatorium fortunei 3.3 - 9.9 parts, Artemisia annua 3.3 - 9.9 parts, Prunus armeniaca 2 - 6 parts, Phaseolus angularis 2 - 6 parts, Fructus Aurantii (stir-fried with bran) 1.5 - 4.5 parts, Areca catechu 1.5 - 4.5 parts, Cyperus rotundus 3 - 9 parts, Magnolia officinalis 1.5 - 4.5 parts, Mentha haplocalyx 1.5 - 4.5 parts, Fructus Setariae Germinatus 4.5 - 13.5 parts, Fructus Hordei Germinatus 4.5 - 13.5 parts, Cinnamomum cassia 0.75 - 2.25 parts, Perilla frutescens 3 - 9 parts, Crataegus pinnatifida (stir-fried) 4.5 - 13.5 parts, Atractylodes lancea 3 - 9 parts, Angelica dahurica 1.5 - 4.5 parts, Citrus reticulata 3 - 9 parts, Pogostemon cablin 6 - 12 parts, Glycyrrhiza glabra 0.75 - 2.25 parts, Aucklandia lappa 1.5 - 4.5 parts, wheat bran 10.6 - 31.8 parts, and flour 5.3 - 15.9 parts.

[0012] A method for processing Jianqu includes the following steps:

[0013] S1. Stir-fry Crataegus pinnatifida to obtain Crataegus pinnatifida (stir-fried);

[0014] S2. Stir-fry Fructus Aurantii with bran to obtain Fructus Aurantii (stir-fried with bran);

[0015] S3. Separate the Herba Polygoni Hydropiperis, Herba Eupatorii, Herba Artemisiae Annuae, Semen Armeniacae Amarum, Semen Phaseoli Angularis, Fructus Aurantii (parched with bran), Semen Arecae, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Herba Menthae, Fructus Setariae Germinatus, Fructus Hordei Germinatus, Cortex Cinnamomi, Folium Perillae, Fructus Crataegi (parched), Rhizoma Atractylodis, Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Herba Pogostemonis, Radix Glycyrrhizae, and Radix Aucklandiae into fine powders respectively.

[0016] S4. Mix the fine powders of Herba Polygoni Hydropiperis, Herba Eupatorii, Herba Artemisiae Annuae, Semen Armeniacae Amarum, Semen Phaseoli Angularis, Fructus Aurantii (parched with bran), Semen Arecae, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Herba Menthae, Fructus Setariae Germinatus, Fructus Hordei Germinatus, Cortex Cinnamomi, Folium Perillae, Fructus Crataegi (parched), Rhizoma Atractylodis, Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Herba Pogostemonis, Radix Glycyrrhizae, and Radix Aucklandiae in proportion to obtain the mixed powder of Jianqu medicinal materials.

[0017] S5. Mix the obtained mixed powder of Jianqu medicinal materials with wheat bran in proportion to obtain the wheat bran mixture.

[0018] S6. Take flour in proportion and add warm boiled water to make a thin paste, and knead it evenly with the wheat bran mixture while it is hot to form a flour mixture.

[0019] S7. Make the flour mixture into lumps and ferment it to obtain the semi-finished product of Jianqu.

[0020] S8. Dry the semi-finished product of Jianqu at low temperature to obtain Jianqu.

[0021] A further improvement to the above solution is that step S1 specifically includes the following steps:

[0022] Preheat the medicine stir-frying machine first. When the temperature reaches 130 °C, feed the materials and stir-fry at 100 - 150 °C for 10 - 30 minutes until the color becomes darker, then take out and let it cool.

[0023] A further improvement to the above solution is that step S2 specifically includes the following steps:

[0024] Preheat the medicine stir-frying machine first. When the temperature reaches 140 °C, sprinkle the wheat bran into the hot pot. When it starts to smoke, add the Fructus Aurantii, and stir-fry at 100 - 150 °C for 30 - 50 minutes until the color becomes darker, the color is darker, and there are occasional scorched spots.

[0025] A further improvement to the above solution is that step S7 specifically includes the following steps:

[0026] Lay the lumpy flour mixture flat in the fermentation tray with gaps between the lumps, cover it with a gunny bag or straw, and in the germination and fermentation room, control the fermentation temperature at 28 - 35 °C and the humidity not lower than 85%. Take it out when the medicine lumps are covered with white mold and have a wine aroma.

[0027] A further improvement to the above solution is that step S8 specifically includes the following steps:

[0028] Lay the semi-finished Jianqu flat in the tray with a uniform spreading thickness, and bake it at 50 - 60 °C for 10 minutes to 8 hours until the moisture content does not exceed 11.0%.

[0029] A further improvement to the above solution is that the raw and auxiliary materials are in the following weight ratio:

[0030] Polygonum hydropiper 3.3 - 9.9 parts, Eupatorium fortunei 3.3 - 9.9 parts, Artemisia annua 3.3 - 9.9 parts, Prunus armeniaca var. ansu 2 - 6 parts, Phaseolus angularis 2 - 6 parts, Aurantii Fructus (stir-fried with bran) 1.5 - 4.5 parts, Areca catechu 1.5 - 4.5 parts, Cyperus rotundus 3 - 9 parts, Magnolia officinalis 1.5 - 4.5 parts, Mentha haplocalyx 1.5 - 4.5 parts, Setaria italica (L.) Beauv. var. germanica (Mill.) Schred 4.5 - 13.5 parts, Hordeum vulgare L. var. nudum Hook.f. 4.5 - 13.5 parts, Cinnamomum cassia Presl 0.75 - 2.25 parts, Perilla frutescens (L.) Britt. 3 - 9 parts, Crataegus pinnatifida Bunge var. major N.E.Br. (stir-fried) 4.5 - 13.5 parts, Atractylodes lancea (Thunb.) DC. 3 - 9 parts, Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook.f. ex Franch. et Sav. 1.5 - 4.5 parts, Citrus reticulata Blanco 3 - 9 parts, Pogostemon cablin (Blanco) Benth. 3 - 9 parts, Glycyrrhiza uralensis Fisch. 0.75 - 2.25 parts, Aucklandia lappa Decne. 1.5 - 4.5 parts, Wheat bran 10.6 - 31.8 parts, Wheat flour 5.3 - 15.9 parts.

[0031] A further improvement to the above solution is that the raw and auxiliary materials are in the following weight ratio:

[0032] Polygonum hydropiper 3.3 - 9.9 parts, Eupatorium fortunei 3.3 - 9.9 parts, Artemisia annua 3.3 - 9.9 parts, Prunus armeniaca var. ansu 2 - 6 parts, Phaseolus angularis 2 - 6 parts, Aurantii Fructus (stir-fried with bran) 1.5 - 4.5 parts, Areca catechu 1.5 - 4.5 parts, Cyperus rotundus 3 - 9 parts, Magnolia officinalis 1.5 - 4.5 parts, Mentha haplocalyx 1.5 - 4.5 parts, Setaria italica (L.) Beauv. var. germanica (Mill.) Schred 4.5 - 13.5 parts, Hordeum vulgare L. var. nudum Hook.f. 4.5 - 13.5 parts, Cinnamomum cassia Presl 0.75 - 2.25 parts, Perilla frutescens (L.) Britt. 3 - 9 parts, Crataegus pinnatifida Bunge var. major N.E.Br. (stir-fried) 4.5 - 13.5 parts, Atractylodes lancea (Thunb.) DC. 3 - 9 parts, Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook.f. ex Franch. et Sav. 1.5 - 4.5 parts, Citrus reticulata Blanco 3 - 9 parts, Pogostemon cablin (Blanco) Benth. 6 - 12 parts, Glycyrrhiza uralensis Fisch. 0.75 - 2.25 parts, Aucklandia lappa Decne. 1.5 - 4.5 parts, Wheat bran 10.6 - 31.8 parts, Wheat flour 5.3 - 15.9 parts.

[0033] The beneficial effects of the present invention are as follows: A kind of Jianqu provided by the present invention, including Polygonum hydropiper, Eupatorium fortunei, Artemisia annua, Prunus armeniaca var. ansu, Phaseolus angularis, Aurantii Fructus (stir-fried with bran), Areca catechu, Cyperus rotundus, Magnolia officinalis, Mentha haplocalyx, Setaria italica (L.) Beauv. var. germanica (Mill.) Schred, Hordeum vulgare L. var. nudum Hook.f., Cinnamomum cassia Presl, Perilla frutescens (L.) Britt., Crataegus pinnatifida Bunge var. major N.E.Br. (stir-fried), Atractylodes lancea (Thunb.) DC., Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook.f. ex Franch. et Sav., Citrus reticulata Blanco, Pogostemon cablin (Blanco), Glycyrrhiza uralensis Fisch., Aucklandia lappa Decne., Wheat bran, Wheat flour;

[0034] Since Eupatorium fortunei Turcz. and Xanthium sibiricum Patrin ex Widder both belong to the category of "diaphoretic and dampness-resolving herbs", but Eupatorium fortunei Turcz. is non-toxic, and in addition, the volatile oil of Eupatorium fortunei Turcz. (such as p-cymene) can promote the secretion of digestive juices, which is in line with the goal of Jianqu in strengthening the spleen and promoting digestion. A kind of Jianqu of the present invention replaces Xanthium sibiricum Patrin ex Widder with Eupatorium fortunei Turcz. which also has the functions of diaphoretic and dampness-resolving, can promote the secretion of digestive juices and is non-toxic. The formula does not contain Xanthium sibiricum Patrin ex Widder with toxicity, which can not only well maintain or even enhance the original efficacy of improving dyspepsia and relieving gastrointestinal discomfort, but also can well avoid liver damage and has better safety;

[0035] In addition, since Pogostemon cablin (Blanco) Benth. has the effects of resolving dampness and regulating the middle-jiao, relieving summer heat and promoting eruption, and the volatile oil of Pogostemon cablin (Blanco) Benth. (such as patchouli alcohol) can promote gastrointestinal peristalsis and enhance the digestive effect. By replacing Xanthium sibiricum Patrin ex Widder in the existing traditional formula with Eupatorium fortunei Turcz. and increasing the proportion of Pogostemon cablin (Blanco) Benth. in the original formula, Eupatorium fortunei Turcz. and Pogostemon cablin (Blanco) Benth. can play a synergistic effect, which can not only well avoid liver damage and has good safety, but also can better enhance the original efficacy of improving dyspepsia and relieving gastrointestinal discomfort. Brief Description of the Drawings: Detailed Description of the Invention:

[0036] Example 1, a kind of Jianqu of the present invention, includes the following raw and auxiliary materials in parts by weight:

[0037] Polygonum criopolitanum Hance 6.6 parts, Eupatorium fortunei Turcz. 6.6 parts, Artemisia annua L. 6.6 parts, Prunus armeniaca L. var. ansu Maxim. 4 parts, Phaseolus angularis Wight 4 parts, Aurantii Fructus Immaturus (stir-fried with bran) 3 parts, Areca catechu L. 3 parts, Cyperus rotundus L. 6 parts, Magnolia officinalis Rehd. et Wils. 3 parts, Mentha haplocalyx Briq. 3 parts, Oryza sativa L. var. germinatus 9 parts, Hordeum vulgare L. var. germinatum 9 parts, Cinnamomum cassia Presl 1.5 parts, Perilla frutescens (L.) Britt. 6 parts, Crataegus pinnatifida Bge. (stir-fried) 9 parts, Atractylodes lancea (Thunb.) DC. 6 parts, Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav. 3 parts, Citrus reticulata Blanco 6 parts, Pogostemon cablin (Blanco) Benth. 6 parts, Glycyrrhiza uralensis Fisch. 1.5 parts, Aucklandia lappa Decne. 3 parts, Wheat bran 21.2 parts, Wheat flour 10.6 parts;

[0038] Example 2, another kind of Jianqu of the present invention, includes the following raw and auxiliary materials in parts by weight:

[0039] Polygonum criopolitanum Hance 6.6 parts, Eupatorium fortunei Turcz. 6.6 parts, Artemisia annua L. 6.6 parts, Prunus armeniaca L. var. ansu Maxim. 4 parts, Phaseolus angularis Wight 4 parts, Aurantii Fructus Immaturus (stir-fried with bran) 3 parts, Areca catechu L. 3 parts, Cyperus rotundus L. 6 parts, Magnolia officinalis Rehd. et Wils. 3 parts, Mentha haplocalyx Briq. 3 parts, Oryza sativa L. var. germinatus 9 parts, Hordeum vulgare L. var. germinatum 9 parts, Cinnamomum cassia Presl 1.5 parts, Perilla frutescens (L.) Britt. 6 parts, Crataegus pinnatifida Bge. (stir-fried) 9 parts, Atractylodes lancea (Thunb.) DC. 6 parts, Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav. 3 parts, Citrus reticulata Blanco 6 parts, Pogostemon cablin (Blanco) Benth. 9 parts, Glycyrrhiza uralensis Fisch. 1.5 parts, Aucklandia lappa Decne. 3 parts, Wheat bran 21.2 parts, Wheat flour 10.6 parts;

[0040] Example 3, a kind of existing traditional Jianqu, includes the following raw and auxiliary materials in parts by weight:

[0041] Polygonum criopolitanum Hance 6.6 parts, Xanthium sibiricum Patrin ex Widder 6.6 parts, Artemisia carvifolia Buch.-Ham. ex Roxb. 6.6 parts, Armeniaca vulgaris Lam. 4 parts, Vigna angularis (Willd.) Ohwi & Ohashi 4 parts, Aurantii Fructus Immaturus (Fried with Bran) 3 parts, Areca catechu L. 3 parts, Cyperus rotundus L. 6 parts, Magnolia officinalis Rehder & E. H. Wilson 3 parts, Mentha haplocalyx Briq. 3 parts, Oryza sativa L. var. germinativa (Matum.) Makino 9 parts, Hordeum vulgare L. var. germinativum Alef. 9 parts, Cinnamomum cassia Presl 1.5 parts, Perilla frutescens (L.) Britt. 6 parts, Crataegus pinnatifida Bunge var. major N. E. Br. (Fried) 9 parts, Atractylodes lancea (Thunb.) DC. 6 parts, Angelica dahurica (Fisch. ex Hoffm.) Benth. & Hook. f. ex Franch. & Sav. 3 parts, Citrus reticulata Blanco 6 parts, Pogostemon cablin (Blanco) Benth. 6 parts, Glycyrrhiza uralensis Fisch. 1.5 parts, Aucklandia lappa Decne. 3 parts, Wheat Bran 21.2 parts, Wheat Flour 10.6 parts;

[0042] Example 4, a method for processing Jianqu, comprising the following steps:

[0043] S1. Stir-fry hawthorn and obtain Crataegus pinnatifida Bunge var. major N. E. Br. (Fried);

[0044] S2. Stir-fry Aurantii Fructus Immaturus with bran and obtain Aurantii Fructus Immaturus (Fried with Bran);

[0045] S3. Separately pulverize Polygonum criopolitanum Hance, Eupatorium fortunei Turcz., Artemisia carvifolia Buch.-Ham. ex Roxb., Armeniaca vulgaris Lam., Vigna angularis (Willd.) Ohwi & Ohashi, Aurantii Fructus Immaturus (Fried with Bran), Areca catechu L., Cyperus rotundus L., Magnolia officinalis Rehder & E. H. Wilson, Mentha haplocalyx Briq., Oryza sativa L. var. germinativa (Matum.) Makino, Hordeum vulgare L. var. germinativum Alef., Cinnamomum cassia Presl, Perilla frutescens (L.) Britt., Crataegus pinnatifida Bunge var. major N. E. Br. (Fried), Atractylodes lancea (Thunb.) DC., Angelica dahurica (Fisch. ex Hoffm.) Benth. & Hook. f. ex Franch. & Sav., Citrus reticulata Blanco, Pogostemon cablin (Blanco) Benth., Glycyrrhiza uralensis Fisch., Aucklandia lappa Decne. into fine powders;

[0046] S4. Mix the pulverized Polygonum criopolitanum Hance, Eupatorium fortunei Turcz., Artemisia carvifolia Buch.-Ham. ex Roxb., Armeniaca vulgaris Lam., Vigna angularis (Willd.) Ohwi & Ohashi, Aurantii Fructus Immaturus (Fried with Bran), Areca catechu L., Cyperus rotundus L., Magnolia officinalis Rehder & E. H. Wilson, Mentha haplocalyx Briq., Oryza sativa L. var. germinativa (Matum.) Makino, Hordeum vulgare L. var. germinativum Alef., Cinnamomum cassia Presl, Perilla frutescens (L.) Britt., Crataegus pinnatifida Bunge var. major N. E. Br. (Fried), Atractylodes lancea (Thunb.) DC., Angelica dahurica (Fisch. ex Hoffm.) Benth. & Hook. f. ex Franch. & Sav., Citrus reticulata Blanco, Pogostemon cablin (Blanco) Benth., Glycyrrhiza uralensis Fisch., Aucklandia lappa Decne. in proportion and obtain the mixed powder of Jianqu medicinal materials;

[0047] S5. Mix the obtained mixed powder of Jianqu medicinal materials with wheat bran in proportion and obtain the wheat bran mixture;

[0048] S6. Take wheat flour in proportion and add warm boiled water to make a thin paste, and knead it evenly with the wheat bran mixture while it is hot to form a flour mixture;

[0049] S7. Make the flour mixture into a dough and ferment it to obtain the semi-finished product of Jianqu;

[0050] S8. Conduct low-temperature drying on the semi-finished product of Jianqu to obtain Jianqu;

[0051] Among them, the raw and auxiliary materials are in the following weight ratio: 3.3 - 9.9 parts of Polygonum hydropiper, 3.3 - 9.9 parts of Eupatorium fortunei, 3.3 - 9.9 parts of Artemisia annua, 2 - 6 parts of Prunus armeniaca, 2 - 6 parts of Phaseolus angularis, 1.5 - 4.5 parts of Fructus Aurantii (parched with bran), 1.5 - 4.5 parts of Areca catechu, 3 - 9 parts of Cyperus rotundus, 1.5 - 4.5 parts of Magnolia officinalis, 1.5 - 4.5 parts of Mentha haplocalyx, 4.5 - 13.5 parts of Fructus Setariae Germinatus, 4.5 - 13.5 parts of Fructus Hordei Germinatus, 0.75 - 2.25 parts of Cinnamomum cassia, 3 - 9 parts of Perilla frutescens, 4.5 - 13.5 parts of Crataegus pinnatifida (parched), 3 - 9 parts of Atractylodes lancea, 1.5 - 4.5 parts of Angelica dahurica, 3 - 9 parts of Citrus reticulata Blanco, 3 - 9 parts of Pogostemon cablin, 0.75 - 2.25 parts of Glycyrrhiza uralensis, 1.5 - 4.5 parts of Aucklandia lappa, 10.6 - 31.8 parts of wheat bran, 5.3 - 15.9 parts of flour;

[0052] Step S1 specifically includes the following steps:

[0053] First, preheat the medicine stirrer. When the temperature reaches 130°C, feed the materials and stir-fry at 100 - 150°C for 10 - 30 minutes until the color becomes darker. Then take out and let it cool. By avoiding the destruction of organic acids (such as citric acid and malic acid) and flavonoids (such as hyperin) in hawthorn caused by high temperature (>150°C), the core medicinal components for strengthening the spleen and promoting digestion are retained. Stir-frying until the color becomes darker is to promote the Maillard reaction to generate flavor substances (such as 5-hydroxymethylfurfural), enhancing the stomach-strengthening effect, so that the efficacy of the Jianqu prepared subsequently is better.

[0054] Step S2 specifically includes the following steps:

[0055] First, preheat the medicine stirrer. When the temperature reaches 140°C, sprinkle the wheat bran into the hot pot. When it starts to smoke, add Fructus Aurantii. Stir-fry at 100 - 150°C for 30 - 50 minutes. By strictly controlling the temperature, stir-fry until the color becomes darker and darker, with occasional charred spots. By strictly controlling the temperature, it can avoid the "undercooked" situation caused by insufficient temperature (<120°C) or the "bitter and charred" situation caused by too high temperature (>160°C) in the traditional process, so that the efficacy of the Jianqu prepared subsequently is better.

[0056] Step S7 specifically includes the following steps:

[0057] Lay the flour mixture made into lumps flat in the fermentation tray, leaving gaps between the lumps to ensure uniform distribution of oxygen, prevent local anaerobic fermentation from producing odors, cover it with a gunny bag or straw, and in the germination and fermentation room, control the fermentation temperature at 28 - 35°C and the humidity not less than 85%, providing the best breeding environment for beneficial bacteria such as Aspergillus oryzae and Saccharomyces cerevisiae. Take it out when the medicine lumps are covered with white mold and have a wine aroma.

[0058] Step S8 specifically includes the following steps:

[0059] Lay the semi-finished Jianqu flat in the tray with a uniform spreading thickness to ensure the permeability of hot air circulation. Bake it at 50 - 60 °C for 10 minutes to 8 hours until the moisture content does not exceed 11.0%. Since excessive moisture (>11%) poses a risk of mildew; the low temperature of 50 - 60 °C can avoid the destruction of components such as volatile oils and digestive enzymes in Jianqu, thus better ensuring the effect of strengthening the spleen and promoting digestion.

[0060] Example 5. The difference between this example and Example 4 lies in:

[0061] The raw and auxiliary materials are in the following weight ratio:

[0062] Polygonum hydropiper 3.3 - 9.9 parts, Eupatorium fortunei 3.3 - 9.9 parts, Artemisia annua 3.3 - 9.9 parts, Prunus armeniaca var. ansu 2 - 6 parts, Phaseolus angularis 2 - 6 parts, Aurantii Fructus Immaturus (stir-fried with bran) 1.5 - 4.5 parts, Areca catechu 1.5 - 4.5 parts, Cyperus rotundus 3 - 9 parts, Magnolia officinalis 1.5 - 4.5 parts, Mentha haplocalyx 1.5 - 4.5 parts, Oryza sativa germinatus 4.5 - 13.5 parts, Hordeum vulgare germinatum 4.5 - 13.5 parts, Cinnamomum cassia 0.75 - 2.25 parts, Perilla frutescens 3 - 9 parts, Crataegus pinnatifida (stir-fried) 4.5 - 13.5 parts, Atractylodes lancea 3 - 9 parts, Angelica dahurica 1.5 - 4.5 parts, Citrus reticulata Blanco 3 - 9 parts, Pogostemon cablin 6 - 12 parts, Glycyrrhiza uralensis 0.75 - 2.25 parts, Aucklandia lappa 1.5 - 4.5 parts, wheat bran 10.6 - 31.8 parts, flour 5.3 - 15.9 parts;

[0063] The rest are the same as in Example 4 and will not be elaborated here.

[0064] By comparing the digestive functions (animal experiments) of Example 1 (a Jianqu formula of the present invention), Example 2 (another Jianqu formula of the present invention), and Example 3 (an existing traditional Jianqu formula), the specific comparison data are as follows:

[0065]

[0066]

[0067] From the above digestive function comparison data, it can be known that the Jianqu formula (the formula in Example 1) with Eupatorium fortunei replacing Xanthium sibiricum is superior to the existing traditional Jianqu formula (the formula in Example 3) in promoting gastrointestinal motility, and the Jianqu formula (the formula in Example 2) with Eupatorium fortunei replacing Xanthium sibiricum and increasing the proportion of Pogostemon cablin is further superior to the existing traditional Jianqu formula (the formula in Example 3) in promoting gastrointestinal motility.

[0068] By conducting sub-chronic toxicity experiments (animal experiments) on Example 1 (a Jianqu formula of the present invention), Example 2 (another Jianqu formula of the present invention), and Example 3 (an existing traditional Jianqu formula), the specific comparison data are as follows:

[0069]

[0070] From the above comparison data of sub-chronic toxicity experiments, it can be known that the existing traditional Jianqu formula (the formula in Example 3) shows mild liver injury (significant increase in ALT / AST). The Jianqu formula with Eupatorium fortunei Turcz. replacing Xanthium sibiricum Patrin ex Widder (the formula in Example 1) and the Jianqu formula with Eupatorium fortunei Turcz. replacing Xanthium sibiricum Patrin ex Widder and increasing the proportion of Pogostemon cablin (Blanco) Benth. (the formula in Example 2) do not show obvious liver injury and the safety is significantly improved.

[0071] By combining the above comparison data on digestive function and the comparison data on sub-chronic toxicity experiments, it can be known that a kind of Jianqu of the present invention comprises the following raw and auxiliary materials in parts by weight:

[0072] Polygonum criopolitanum Hance 3.3 - 9.9 parts, Eupatorium fortunei Turcz. 3.3 - 9.9 parts, Artemisia annua L. 3.3 - 9.9 parts, Prunus armeniaca L. var. ansu Maxim. 2 - 6 parts, Phaseolus angularis Wight 2 - 6 parts, Aurantii Fructus Immaturus (stir-fried with bran) 1.5 - 4.5 parts, Areca catechu L. 1.5 - 4.5 parts, Cyperus rotundus L. 3 - 9 parts, Magnolia officinalis Rehd. et Wils. 1.5 - 4.5 parts, Mentha haplocalyx Briq. 1.5 - 4.5 parts, Oryza sativa L. germinated 4.5 - 13.5 parts, Hordeum vulgare L. germinated 4.5 - 13.5 parts, Cinnamomi Cortex 0.75 - 2.25 parts, Perilla frutescens (L.) Britt. 3 - 9 parts, Crataegi Fructus (stir-fried) 4.5 - 13.5 parts, Atractylodes lancea (Thunb.) DC. 3 - 9 parts, Angelicae Dahuricae Radix 1.5 - 4.5 parts, Citri Reticulatae Pericarpium 3 - 9 parts, Pogostemon cablin (Blanco) Benth. 3 - 9 parts, Glycyrrhizae Radix et Rhizoma 0.75 - 2.25 parts, Aucklandiae Radix 1.5 - 4.5 parts, Wheat bran 10.6 - 31.8 parts, Wheat flour 5.3 - 15.9 parts; Since Eupatorium fortunei Turcz. and Xanthium sibiricum Patrin ex Widder both belong to "diaphoretic and dampness-resolving herbs", but Eupatorium fortunei Turcz. is non-toxic. In addition, the volatile oil of Eupatorium fortunei Turcz. (such as p-cymene) can promote the secretion of digestive juice, which meets the goal of strengthening the spleen and promoting digestion of Jianqu. By replacing 3.3 - 9.9 parts of Xanthium sibiricum Patrin ex Widder in the existing traditional formula with 3.3 - 9.9 parts of Eupatorium fortunei Turcz., it can not only well maintain or even enhance the original efficacy of improving dyspepsia and relieving gastrointestinal discomfort, but also well avoid liver damage and has better safety.

[0073] By combining the above comparison data on digestive function and the comparison data on sub-chronic toxicity experiments, it can be known that a kind of Jianqu of the present invention comprises the following raw and auxiliary materials in parts by weight:

[0074] Polygonum criopolitanum Hance 3.3 - 9.9 parts, Eupatorium fortunei Turcz. 3.3 - 9.9 parts, Artemisia annua L. 3.3 - 9.9 parts, Prunus armeniaca L. var. ansu Maxim. 2 - 6 parts, Phaseolus angularis Wight 2 - 6 parts, Aurantii Fructus Immaturus (parched with bran) 1.5 - 4.5 parts, Areca catechu L. 1.5 - 4.5 parts, Cyperus rotundus L. 3 - 9 parts, Magnolia officinalis Rehd. et Wils. 1.5 - 4.5 parts, Mentha haplocalyx Briq. 1.5 - 4.5 parts, Fructus Setariae Germinatus 4.5 - 13.5 parts, Fructus Hordei Germinatus 4.5 - 13.5 parts, Cinnamomi Cortex 0.75 - 2.25 parts, Perilla frutescens (L.) Britt. 3 - 9 parts, Crataegi Fructus (parched) 4.5 - 13.5 parts, Atractylodes lancea (Thunb.) DC. 3 - 9 parts, Angelicae Dahuricae Radix 1.5 - 4.5 parts, Citri Reticulatae Pericarpium 3 - 9 parts, Pogostemon cablin (Blanco) Benth. 6 - 12 parts, Glycyrrhizae Radix et Rhizoma 0.75 - 2.25 parts, Aucklandiae Radix 1.5 - 4.5 parts, Wheat Bran 10.6 - 31.8 parts, Wheat Flour 5.3 - 15.9 parts; Since Pogostemon cablin has the effects of promoting digestion and regulating the middle energizer, relieving summer heat and inducing sweating, and the volatile oil of Pogostemon cablin (such as patchouli alcohol) can promote gastrointestinal peristalsis and enhance the digestion-promoting effect. By replacing 3.3 - 9.9 parts of Xanthium sibiricum Patrin ex Widder in the existing traditional formula with 3.3 - 9.9 parts of Eupatorium fortunei Turcz. and increasing the proportion of Pogostemon cablin in the original formula, Eupatorium fortunei Turcz. can play a synergistic effect with Pogostemon cablin, not only can well avoid liver damage and has good safety, but also can better improve the original efficacy of improving dyspepsia and relieving gastrointestinal discomfort.

[0075] Of course, the above description is only the preferred embodiment of the present invention. Therefore, all equivalent changes or modifications made according to the structures, features and principles described in the scope of the present invention patent application are included in the scope of the present invention patent application.

Claims

1. A Jianqu, characterized in that, It includes the following raw and auxiliary materials: Polygonum hydropiper, Eupatorium fortunei, Artemisia annua, Prunus armeniaca, adzuki bean, Fructus Aurantii (parched with bran), Semen Arecae, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Mentha haplocalyx, Fructus Setariae Germinatus, Fructus Hordei Germinatus, Cortex Cinnamomi, Perilla frutescens, Fructus Crataegi (parched), Atractylodes lancea, Angelica dahurica, Pericarpium Citri Reticulatae, Pogostemon cablin, Glycyrrhiza uralensis, Radix Aucklandiae, wheat bran, flour.

2. A Jianqu according to claim 1, characterized in that, It includes the following raw and auxiliary materials with the following weight ratios: Polygonum hydropiper 3.3 - 9.9 parts, Eupatorium fortunei 3.3 - 9.9 parts, Artemisia annua 3.3 - 9.9 parts, Prunus armeniaca 2 - 6 parts, adzuki bean 2 - 6 parts, Fructus Aurantii (parched with bran) 1.5 - 4.5 parts, Semen Arecae 1.5 - 4.5 parts, Rhizoma Cyperi 3 - 9 parts, Cortex Magnoliae Officinalis 1.5 - 4.5 parts, Mentha haplocalyx 1.5 - 4.5 parts, Fructus Setariae Germinatus 4.5 - 13.5 parts, Fructus Hordei Germinatus 4.5 - 13.5 parts, Cortex Cinnamomi 0.75 - 2.25 parts, Perilla frutescens 3 - 9 parts, Fructus Crataegi (parched) 4.5 - 13.5 parts, Atractylodes lancea 3 - 9 parts, Angelica dahurica 1.5 - 4.5 parts, Pericarpium Citri Reticulatae 3 - 9 parts, Pogostemon cablin 3 - 9 parts, Glycyrrhiza uralensis 0.75 - 2.25 parts, Radix Aucklandiae 1.5 - 4.5 parts, wheat bran 10.6 - 31.8 parts, flour 5.3 - 15.9 parts.

3. A Jianqu according to claim 1, characterized in that: It includes the following raw and auxiliary materials with the following weight ratios: Polygonum hydropiper 3.3 - 9.9 parts, Eupatorium fortunei 3.3 - 9.9 parts, Artemisia annua 3.3 - 9.9 parts, Prunus armeniaca 2 - 6 parts, adzuki bean 2 - 6 parts, Fructus Aurantii (parched with bran) 1.5 - 4.5 parts, Semen Arecae 1.5 - 4.5 parts, Rhizoma Cyperi 3 - 9 parts, Cortex Magnoliae Officinalis 1.5 - 4.5 parts, Mentha haplocalyx 1.5 - 4.5 parts, Fructus Setariae Germinatus 4.5 - 13.5 parts, Fructus Hordei Germinatus 4.5 - 13.5 parts, Cortex Cinnamomi 0.75 - 2.25 parts, Perilla frutescens 3 - 9 parts, Fructus Crataegi (parched) 4.5 - 13.5 parts, Atractylodes lancea 3 - 9 parts, Angelica dahurica 1.5 - 4.5 parts, Pericarpium Citri Reticulatae 3 - 9 parts, Pogostemon cablin 6 - 12 parts, Glycyrrhiza uralensis 0.75 - 2.25 parts, Radix Aucklandiae 1.5 - 4.5 parts, wheat bran 10.6 - 31.8 parts, flour 5.3 - 15.9 parts.

4. A method for processing Jianqu, characterized in that, It includes the following steps: S1. Parched Fructus Crataegi to obtain Fructus Crataegi (parched); S2. Parched Fructus Aurantii with bran to obtain Fructus Aurantii (parched with bran); S3. Respectively pulverize Polygonum hydropiper, Eupatorium fortunei, Artemisia annua, Prunus armeniaca, adzuki bean, Fructus Aurantii (parched with bran), Semen Arecae, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Mentha haplocalyx, Fructus Setariae Germinatus, Fructus Hordei Germinatus, Cortex Cinnamomi, Perilla frutescens, Fructus Crataegi (parched), Atractylodes lancea, Angelica dahurica, Pericarpium Citri Reticulatae, Pogostemon cablin, Glycyrrhiza uralensis, Radix Aucklandiae into fine powder; S4. Mix the pulverized Polygonum hydropiper, Eupatorium fortunei, Artemisia annua, Prunus armeniaca, adzuki bean, Fructus Aurantii (parched with bran), Semen Arecae, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Mentha haplocalyx, Fructus Setariae Germinatus, Fructus Hordei Germinatus, Cortex Cinnamomi, Perilla frutescens, Fructus Crataegi (parched), Atractylodes lancea, Angelica dahurica, Pericarpium Citri Reticulatae, Pogostemon cablin, Glycyrrhiza uralensis, Radix Aucklandiae in proportion to obtain the mixed powder of Jianqu medicinal materials; S5. Mix the obtained mixed powder of Jianqu medicinal materials with wheat bran in proportion to obtain the wheat bran mixture; S6. Take flour in proportion and add warm water to make a thin paste, and knead it evenly with the wheat bran mixture while it is hot to obtain the flour mixture; S7. Make the flour mixture into lumps and ferment to obtain the semi-finished product of Jianqu; S8. Dry the semi-finished product of Jianqu at low temperature to obtain Jianqu.

5. A method for processing Jianqu according to claim 4, characterized in that: The specific steps of step S1 include the following steps: Preheat the medicinal herb stir-frying machine first. When the temperature reaches 130°C, feed the materials and stir-fry at 100 - 150°C for 10 - 30 minutes until the color darkens. Then take out and let it cool.

6. A method for processing Jianqu according to claim 4, characterized in that: The specific steps of step S2 are as follows: Preheat the medicinal herb stir-frying machine first. When the temperature reaches 140°C, sprinkle wheat bran into the hot pot. When it starts to smoke, add Fructus Aurantii. Stir-fry at 100 - 150°C for 30 - 50 minutes until the color darkens, the color is darker, and there are occasional scorched spots.

7. A method for processing Jianqu according to claim 4, characterized in that: The specific steps of step S7 are as follows: Lay the flour mixture made into lumps flat in the fermentation tray with gaps between the lumps. Cover it with burlap or straw. In the germination and fermentation room, control the fermentation temperature at 28 - 35°C and the humidity not less than 85%. Take it out when the medicinal lumps are covered with white mold all over and have the aroma of wine.

8. A method for processing Jianqu according to claim 4, characterized in that: The specific steps of step S8 are as follows: Lay the semi-finished Jianqu flat in the tray with a uniform spreading thickness. Bake at 50 - 60°C for 10 minutes - 8 hours until the moisture content does not exceed 11.0%.

9. A method for processing Jianqu according to any one of claims 4-8, characterized in that: The raw and auxiliary materials are in the following weight ratio: Polygonum hydropiper 3.3 - 9.9 parts, Eupatorium fortunei 3.3 - 9.9 parts, Artemisia annua 3.3 - 9.9 parts, Prunus armeniaca var. ansu 2 - 6 parts, Phaseolus angularis 2 - 6 parts, Fructus Aurantii (fried with bran) 1.5 - 4.5 parts, Areca catechu 1.5 - 4.5 parts, Cyperus rotundus 3 - 9 parts, Magnolia officinalis 1.5 - 4.5 parts, Mentha haplocalyx 1.5 - 4.5 parts, Setaria italica (L.) Beauv. var. germanica (Mill.) Schred 4.5 - 13.5 parts, Hordeum vulgare L. var. nudum Hook.f. 4.5 - 13.5 parts, Cinnamomum cassia Presl 0.75 - 2.25 parts, Perilla frutescens (L.) Britt. 3 - 9 parts, Crataegus pinnatifida Bge. var. major N.E.Br. 4.5 - 13.5 parts, Atractylodes lancea (Thunb.) DC. 3 - 9 parts, Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana (Boiss.) Shan et Yuan 1.5 - 4.5 parts, Citrus reticulata Blanco 3 - 9 parts, Pogostemon cablin (Blanco) Benth. 3 - 9 parts, Glycyrrhiza uralensis Fisch. 0.75 - 2.25 parts, Aucklandia lappa Decne. 1.5 - 4.5 parts, wheat bran 10.6 - 31.8 parts, flour 5.3 - 15.9 parts.

10. A method for processing Jianqu according to any one of claims 4-8, characterized in that: The raw and auxiliary materials are in the following weight ratio: Polygonum hydropiper 3.3 - 9.9 parts, Eupatorium fortunei 3.3 - 9.9 parts, Artemisia annua 3.3 - 9.9 parts, Prunus armeniaca var. ansu 2 - 6 parts, Phaseolus angularis 2 - 6 parts, Fructus Aurantii (fried with bran) 1.5 - 4.5 parts, Areca catechu 1.5 - 4.5 parts, Cyperus rotundus 3 - 9 parts, Magnolia officinalis 1.5 - 4.5 parts, Mentha haplocalyx 1.5 - 4.5 parts, Setaria italica (L.) Beauv. var. germanica (Mill.) Schred 4.5 - 13.5 parts, Hordeum vulgare L. var. nudum Hook.f. 4.5 - 13.5 parts, Cinnamomum cassia Presl 0.75 - 2.25 parts, Perilla frutescens (L.) Britt. 3 - 9 parts, Crataegus pinnatifida Bge. var. major N.E.Br. 4.5 - 13.5 parts, Atractylodes lancea (Thunb.) DC. 3 - 9 parts, Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana (Boiss.) Shan et Yuan 1.5 - 4.5 parts, Citrus reticulata Blanco 3 - 9 parts, Pogostemon cablin (Blanco) Benth. 6 - 12 parts, Glycyrrhiza uralensis Fisch. 0.75 - 2.25 parts, Aucklandia lappa Decne. 1.5 - 4.5 parts, wheat bran 10.6 - 31.8 parts, flour 5.3 - 15.9 parts.

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