Traditional Chinese medicine preparation for strengthening spleen, harmonizing stomach and promoting digestion and preparation method thereof

Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a spleen-strengthening stomach-harmonizing digestion-promoting traditional Chinese medicine preparation and a preparation method thereof. The traditional Chinese medicine preparation is prepared from Chinese yam, ginseng, bighead atractylodes rhizome, processed rhizoma atractylodis, poria cocos, gordon euryale seed, coix seed, white hyacinth bean, lotus seed, fried endothelium corneum gigeriae galli, raw hawthorn, medicated leaven, red yeast rice, fried rice sprout and liquorice. The preparation comprises an extract and a solid dispersant. By changing the preparation process, a new dosage form selection is provided for the traditional Chinese medicine decoction, so that the traditional Chinese medicine decoction is more convenient to take, and the dosage is more accurate to grasp.

Description

Technical Field

[0001] The present invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine preparation for strengthening the spleen and stomach and promoting digestion, and a preparation method thereof. Summary of the Invention

[0002] According to the data statistics of the World Health Organization, in recent years, the incidence rate of gastric diseases has been increasing year by year, reaching about 80%.

[0003] Although most of them are minor diseases, such as acute gastritis, chronic gastritis, digestive tract ulcers, etc., the impact is not very significant in the short term. However, if not treated in time, during the gradual development of the condition, it is bound to affect the quality of life of patients, and even induce cell carcinogenesis, threatening life safety.

[0004] The "2023 Edition of the Research on the Current Situation and Development Trend Analysis of the Chinese Gastric Medicine Market" released by the Market Research Network believes that gastric acid is a safety guard for protecting the intestines from germs. Experts point out that the incidence rate of acid-related diseases is on the rise globally year by year. Due to the accelerating work rhythm, fierce competition, and bad living habits, the incidence rate of gastric diseases is getting higher and higher. The usage amount of gastric medicines in hospitals shows an increasing trend year by year. The double increase in the diagnosis and treatment rate and incidence rate of gastric disease patients has promoted the rapid growth of the gastric medicine market every year.

[0005] With the development of society, changes in the environment, population structure, and people's lifestyle, the incidence rate of digestive system diseases mainly caused by smoking, drinking, emotional stress, etc. has been increasing year by year. There are many medicines for treating gastrointestinal diseases in the pharmaceutical market, such as: domperidone, Sanjiuweitai, Weixian U, Jianweixiaoshi tablets, Lizhu Dole, Daxi, etc. However, in the market, varieties such as Janssen's domperidone, Xiuzheng's Sidalin, Kuihua's Weikangling, and Bayer's Daxi dominate. In the market sales of gastric medicines, domperidone, Daxi tablets, Jianweixiaoshi tablets, Sidalin capsules, etc. are the main medicines for gastrointestinal diseases, occupying half of the gastrointestinal medicine market.

[0006] Traditional Chinese medicine has unique curative effects on the treatment of gastric diseases, treating both the symptoms and the root causes. Its dosage form is mainly decoction. The advantage is that the decoction belongs to the solution type, with fast absorption and rapid efficacy. The disadvantage is that for patients, the preparation of the decoction is time-consuming, and it is also inconvenient for storage, transportation, carrying, and taking, and the active ingredients are easily decomposed; changing the traditional Chinese medicine decoction into extract and solid dispersant avoids the above disadvantages of the decoction. The preparation process of the extract and solid dispersant is strictly controlled, with stable quality and curative effect, and has the characteristics of fast absorption, convenient storage, transportation, carrying, and taking, safe and effective; moreover, the dosage is small, especially suitable for children and infants. However, there is currently a lack of a preparation method for related preparations. Summary of the Invention

[0008] To solve the above problems, the present invention provides a traditional Chinese medicine preparation for strengthening the spleen and stomach and promoting digestion, which is made from Chinese yam, ginseng, atractylodes macrocephala, processed atractylodes lancea, poria cocos, euryale ferox, coix seed, white hyacinth bean, lotus seed, stir-fried gallus gallus domesticus gizzard-membrane, raw hawthorn, fermented medicated leaven, monascus, stir-fried germinated barley and liquorice.

[0009] Furthermore, the traditional Chinese medicine preparation includes an extract and a solid dispersant.

[0010] The present invention also provides a preparation method for the above traditional Chinese medicine preparation, including the following steps:

[0011] (1) Weigh Chinese yam, ginseng, atractylodes macrocephala, processed atractylodes lancea, poria cocos, euryale ferox, coix seed, white hyacinth bean, lotus seed, stir-fried gallus gallus domesticus gizzard-membrane, raw hawthorn, fermented medicated leaven, monascus, stir-fried germinated barley and liquorice according to the formula;

[0012] (2) Wash the above medicinal materials, dry them in the air, and crush them into powders;

[0013] (3) Put the powders in step (2) into a multi-functional extraction tank, add water and heat, then filter to obtain filtrate and residue;

[0014] (4) Put the residue in step (3) into a multi-functional extraction tank, add water at 6 - 8 times the amount of the medicinal materials, heat for 2 - 3 h, and filter to obtain filtrate and residue;

[0015] (5) Combine the filtrate in step (3) and the filtrate in step (4), filter, and let it stand;

[0016] (6) Pump the supernatant of the filtrate after standing in step (5) into a refrigeration tank for centrifugal separation in a cold sediment treatment room;

[0017] (7) Pump the filtrate after centrifugation in step (6) into another refrigeration tank for cold storage for 24 - 36 h;

[0018] (8) Filter and sterilize the filtrate in the refrigeration tank in step (7);

[0019] (9) Pump the sterilized filtrate in step (8) into a dispensing tank in a dispensing room through a closed pipeline for sterilization;

[0020] (10) Add fermented medicated leaven and monascus in step (1) to the dispensing tank containing the filtrate after sterilization in step (9), cover the tank lid, heat to boiling, cool down, filter, and concentrate to obtain an extract;

[0021] (11) Clean, dry, and sterilize the extract bottles in a drying room;

[0022] (12) Fill the extract in step (10) into the extract bottles in step (11), seal the caps, sterilize, and package to obtain the finished extract agent;

[0023] (13) Add the Jian Shen Qu and Hong Qu in (1) to the liquid preparation tank containing the sterilized filtrate in (9), and use a pressure spray dryer to prepare the solid dispersant. After packaging, it is the finished solid dispersant.

[0024] Further, the powder described in step (2) is 20-40 mesh powder.

[0025] Further, the amount of water added in step (3) is 8-10 times that of the medicinal materials; the heating time is 3-4 h.

[0026] The present invention has the following beneficial effects:

[0027] By changing the preparation process, the present invention provides a new dosage form option for traditional Chinese medicine decoctions, making them more convenient to take and the dosage more accurately controlled. Detailed implementation manners

[0028] Now, various exemplary implementation manners of the present invention will be described in detail. In the examples, unless otherwise specified, all methods are conventional methods, and unless otherwise specified, all reagents used are conventional commercially available reagents or reagents prepared by conventional methods. This detailed description should not be construed as a limitation of the present invention, but should be understood as a more detailed description of certain aspects, characteristics, and implementation manners of the present invention.

[0029] It should be understood that the terms used in the present invention are only for describing specific implementation manners and are not used to limit the present invention. Additionally, for the numerical ranges in the present invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Any intermediate value within any stated value or stated range, as well as each smaller range between any other stated value or intermediate value within the stated range, is also included in the present invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0030] Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the present invention pertains. Although the present invention only describes preferred methods and materials, any methods and materials similar or equivalent to those described herein can also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials related to the documents. In case of conflict with any incorporated document, the content of this specification shall prevail.

[0031] Without departing from the scope or spirit of the present invention, various improvements and changes can be made to the specific implementation manners of the present invention specification, which are obvious to those skilled in the art. Other implementation manners obtained from the present invention specification are obvious to those skilled in the art. The present invention specification and examples are only exemplary.

[0032] Regarding the terms "including", "comprising", "having", "containing", etc. used in this article, they are all open-ended terms, meaning including but not limited to.

[0033] The types of traditional Chinese medicines involved in this product and their functions and indications are as follows:

[0034] 1. Yam: The food with the function of nourishing the spleen and stomach is first recommended as yam, which is an excellent product for moistening the lungs, strengthening the spleen, and tonifying the kidneys.

[0035] Yam has the functions of strengthening the spleen and stomach and promoting digestion. Clinically, yam is often used to treat spleen and stomach weakness, loss of appetite, fatigue, diarrhea and other diseases, and also has the effects of tonifying the kidney essence, relieving cough by moistening the lungs, reducing blood sugar, and prolonging life.

[0036] 2. Ginseng: Ginseng has the effects of greatly tonifying primordial qi, restoring pulse and arresting collapse, invigorating the spleen and benefiting the lungs, promoting the production of body fluid and nourishing blood, and calming the mind and improving intelligence. It is used for deficiency of vital energy with tendency to collapse, cold limbs and feeble pulse, weakness of the spleen with reduced appetite, cough and dyspnea due to lung deficiency, thirst due to consumption of body fluid, internal heat and polydipsia, deficiency of qi and blood, chronic illness and general debility, palpitation and insomnia, impotence and cold womb.

[0037] 3. Atractylodes macrocephala: Atractylodes macrocephala has the functions of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, stopping sweating, and preventing miscarriage. It is used for weakness of the spleen with reduced appetite, abdominal distension and diarrhea, dizziness and palpitation due to retention of phlegm-fluid, edema, spontaneous sweating, and threatened abortion.

[0038] 4. Rhizoma Atractylodis: Rhizoma Atractylodis has the functions of drying dampness and strengthening the spleen, dispelling wind and cold. This medicine is often used clinically to treat abdominal distension, loss of appetite, lassitude, edema and diarrhea caused by dampness obstructing the spleen and stomach. For example, the famous ancient prescription Pingwei Powder is used to treat these symptoms.

[0039] 5. Poria: Poria has the effects of promoting diuresis to eliminate dampness, benefiting the spleen and protecting the kidneys, calming the mind and promoting the production of body fluid. Long-term consumption of Poria can make people "get rid of all diseases, moisten the skin, and prolong life".

[0040] 6. Gorgon fruit: Gorgon fruit has the effects of astringing the kidney and arresting seminal emission, strengthening the spleen and stopping diarrhea. It can treat chronic diarrhea, frequent urination, spermatorrhea, leukorrhea in women, soreness of the waist and other diseases. It also has the functions of strengthening the spleen and tonifying the kidney, removing dampness and promoting diuresis, and can be used to treat diarrhea caused by spleen deficiency and dampness. At the same time, it contains rich starch, various vitamins and minerals, which can meet the nutritional needs of the human body and has the effect of preventing aging. Gorgon fruit is sweet, astringent and flat in nature, and is an excellent medicinal and edible product for tonifying and strengthening the body, with the functions of replenishing middle qi, strengthening the spleen and tonifying the kidney, and arresting seminal emission and leukorrhea.

[0041] 7. Coix seed: Coix seed has the effects of promoting diuresis to remove dampness, alleviating spasm, clearing heat and discharging pus, and strengthening the spleen. Coix seed can also be used to treat diarrhea due to spleen deficiency, and is often used in combination with drugs for strengthening the spleen and promoting diuresis such as Atractylodes macrocephala and yam.

[0042] 8. White hyacinth bean: White hyacinth bean has the functions of strengthening the spleen and stomach, clearing away summer heat and dampness. It is used for weakness of the spleen and stomach, diarrhea due to summer heat and dampness.

[0043] 9. Lotus seeds have the effects of invigorating the spleen and stopping diarrhea, arresting vaginal discharge, tonifying the kidney and astringing essence, and calming the mind and soothing the nerves. It can be used to treat symptoms such as spleen deficiency diarrhea, vaginal discharge, spermatorrhea, palpitation, and insomnia.

[0044] 10. Stir-fried chicken gizzard-membrane has the effects of strengthening the stomach and promoting digestion, astringing essence and arresting seminal emission. Clinically, it is widely used in vomiting, diarrhea, dyspepsia, infantile malnutrition, enuresis, spermatorrhea, and can also be used in the treatment of cholelithiasis, urinary calculi and other diseases.

[0045] 11. Raw hawthorn has the effects of promoting digestion and invigorating the stomach, stopping dysentery and reducing blood pressure, dispersing stasis and eliminating accumulation, increasing appetite, promoting qi movement and activating blood circulation. Among the flavonoid components contained in hawthorn, there is a compound called vitexin, which has anti-cancer effects. Regular consumption of hawthorn is not only of great benefit to cancer prevention, but also reduces cholesterol and prevents and treats cardiovascular and cerebrovascular diseases such as hypertension, coronary heart disease, and arteriosclerosis. Hawthorn decoction has a strong antibacterial effect and can treat diseases such as bacillary dysentery and enteritis.

[0046] 12. Jianqu has the effects of strengthening the spleen and promoting digestion, regulating qi and eliminating dampness, and relieving exterior syndrome. It is used to treat chest stuffiness and fullness due to indigestion, abdominal distension, vomiting and diarrhea, dysentery, headache due to cold, and improper feeding in children.

[0047] 13. The traditional Chinese medicine Hongqu has the effects of strengthening the spleen and promoting digestion, promoting blood circulation and removing stasis, and reducing lipid.

[0048] (1) Strengthening the spleen and promoting digestion: Hongqu is a commonly used traditional Chinese medicine. If there is loss of appetite or indigestion in daily life, you can eat some appropriately under the guidance of a doctor, which has the effect of strengthening the stomach and promoting digestion.

[0049] (2) Promoting blood circulation and removing stasis: If a woman has incomplete lochia after childbirth or has suffered from traumatic injury, Hongqu can be used under the guidance of a doctor, which can promote the discharge of lochia and also promote the rapid subsidence of swelling.

[0050] (3) Reducing lipid: If the body is overweight or has hyperlipidemia, you can eat some Hongqu appropriately, which can inhibit the body's absorption of fat and thus achieve the effect of reducing lipid.

[0051] 14. Stir-fried germinated barley has the effects of strengthening the spleen and promoting appetite, regulating the middle energizer and promoting digestion. It is used to treat indigestion, abdominal distension, diarrhea, and loss of appetite.

[0052] 15. Licorice

[0053] (1) It is used for heart qi deficiency, palpitations, intermittent pulse, and spleen qi deficiency, lassitude and weakness, etc.

[0054] (2) It is used for carbuncles, sores and ulcers, sore throat, etc. It can be used alone, taken orally or applied topically, or used in combination.

[0055] (3) It is used for asthma and cough. It can be used alone or in combination with other drugs.

[0056] (4) For stomachache, abdominal pain, gastrocnemius spasm pain, etc.

[0057] (5) It is used to moderate the potency of certain drugs. In addition, this product is also commonly used to harmonize various drugs in many prescriptions.

[0058] Example 1:

[0059] 1. A preparation method for converting a traditional Chinese medicine decoction for strengthening the spleen and stomach and promoting digestion into an extract and a solid dispersant, characterized by the following steps:

[0060] (1) The formula consists of Chinese yam, ginseng, atractylodes macrocephala, processed atractylodes lancea, poria cocos, euryale ferox, coix seed, white hyacinth bean, lotus seed, stir-fried chicken gizzard-membrane, raw hawthorn, Jianqu (medicated leaven), red yeast rice, stir-fried germinated barley, and licorice;

[0061] (2) Wash the Chinese yam, ginseng, atractylodes macrocephala, processed atractylodes lancea, poria cocos, euryale ferox, coix seed, white hyacinth bean, lotus seed, stir-fried chicken gizzard-membrane, raw hawthorn, stir-fried germinated barley, and licorice in (1), dry them in the air, and crush them into 20-mesh powder;

[0062] (3) Put the powder of Chinese yam, ginseng, atractylodes macrocephala, processed atractylodes lancea, poria cocos, euryale ferox, coix seed, white hyacinth bean, lotus seed, stir-fried chicken gizzard-membrane, raw hawthorn, stir-fried germinated barley, and licorice in (2) into a multi-functional extraction tank, add 8 times the amount of water as the medicinal materials, heat for 3 h, filter, and obtain filtrate and residue;

[0063] (4) Put the residue in (3) into a multi-functional extraction tank, add 6 times the amount of water as the medicinal materials, heat for 2 h, filter, and obtain filtrate and residue;

[0064] (5) Combine the filtrate in (3) and the filtrate in (4), filter, and let it stand;

[0065] (6) Pump the supernatant of the filtrate after standing in (5) into a refrigeration tank and perform centrifugal separation in the cold sediment treatment room; [[ID=3)]]

[0066] (7) Pump the filtrate after centrifugation in (6) into another refrigeration tank and store it refrigerated for 24 h;

[0067] (8) Filter and sterilize the filtrate in the refrigeration tank in (7);

[0068] (9) Pump the sterilized filtrate in (8) into the dispensing tank in the dispensing room through a closed pipeline for sterilization;

[0069] (10) Add Jianqu (medicated leaven) and red yeast rice in (1) to the dispensing tank containing the filtrate after sterilization in (9), cover the tank lid, heat to boiling, cool down, filter, and concentrate to obtain an extract;

[0070] (11) Wash, dry, and sterilize the extract bottles in the drying room;

[0071] (12) Fill the extract in (10) into the extract bottle in (11), seal the cap, sterilize it, and it becomes the finished extract after packaging;

[0072] (13) Add the Jian Shenqu and Hong Qu in (1) to the liquid preparation tank containing the filtrate sterilized in (9), and use a pressure spray dryer to prepare the solid dispersant, which becomes the finished solid dispersant after packaging.

[0073] Example 2:

[0074] 1. A preparation method for converting a traditional Chinese medicine decoction for strengthening the spleen and stomach and promoting digestion into an extract and a solid dispersant, characterized by the following steps:

[0075] (1) The formula composition is Chinese yam, ginseng, Atractylodes macrocephala, processed Atractylodes lancea, Poria cocos, Gorgon fruit, Coix seed, White hyacinth bean, Lotus seed, stir-fried Endothelium corneum gigeriae galli, raw Hawthorn fruit, Jian Shenqu, Hong Qu, stir-fried Germinated barley, Licorice root;

[0076] (2) Wash, dry, and pulverize the Chinese yam, ginseng, Atractylodes macrocephala, processed Atractylodes lancea, Poria cocos, Gorgon fruit, Coix seed, White hyacinth bean, Lotus seed, stir-fried Endothelium corneum gigeriae galli, raw Hawthorn fruit, stir-fried Germinated barley, and Licorice root in (1) into 40-mesh powder;

[0077] (3) Put the powder in (2) into a multi-functional extraction tank, add water 10 times the amount of the medicinal materials, heat for 4 hours, filter, and obtain the filtrate and residue;

[0078] (4) Put the residue in (3) into a multi-functional extraction tank, add water 8 times the amount of the medicinal materials, heat for 3 hours, filter, and obtain the filtrate and residue;

[0079] (5) Combine the filtrate in (3) and the filtrate in (4), filter, and let it stand;

[0080] (6) Pump the supernatant of the filtrate after standing in (5) into a refrigeration tank and perform centrifugal separation in the cold sediment treatment room;

[0081] (7) Pump the filtrate after centrifugation in (6) into another refrigeration tank and store it refrigerated for 36 hours;

[0082] (8) Filter and sterilize the filtrate in the refrigeration tank in (7):

[0083] (9) Pump the sterilized filtrate in (8) into the liquid preparation tank in the liquid preparation room through a closed pipeline for sterilization;

[0084] (10) Add the Jian Shenqu and Hong Qu in (1) to the liquid preparation tank containing the filtrate sterilized in (9), cover the tank lid, heat to boiling, cool down, filter, and concentrate to obtain the extract;

[0085] (11) Wash, dry, and sterilize the extract bottles in the drying room;

[0086] (12) The extract in (10) is filled into the extract bottle (11), capped, sterilized, and then packaged to obtain the finished extract agent;

[0087] (13) The Jian Shenqu and Hong Qu in (1) are added to the liquid preparation tank containing the filtrate sterilized in (9), and a solid dispersant is prepared by a pressure spray dryer, and then packaged to obtain the finished solid dispersant.

[0088] The above embodiments are only descriptions of the preferred embodiments of the present invention, and do not limit the scope of the present invention. Without departing from the design spirit of the present invention, various deformations and improvements made by those of ordinary skill in the art to the technical solutions of the present invention shall fall within the protection scope determined by the claims of the present invention.

Claims

1. A traditional Chinese medicine preparation for invigorating the spleen, regulating the stomach and promoting digestion, characterized in that, It is made from Chinese yam, ginseng, atractylodes macrocephala, processed atractylodes lancea, poria cocos, euryale ferox, coix seed, white hyacinth bean, lotus seed, stir-fried endothelium corneum gigeriae galli, raw hawthorn, medicated leaven, red yeast rice, stir-fried fructus setariae germinatus and liquorice root.

2. The traditional Chinese medicine preparation according to claim 1, characterized in that, The traditional Chinese medicine preparation includes an extract and a solid dispersant.

3. A preparation method of the traditional Chinese medicine preparation according to claim 1, characterized in that, It includes the following steps: (1) Weigh Chinese yam, ginseng, atractylodes macrocephala, processed atractylodes lancea, poria cocos, euryale ferox, coix seed, white hyacinth bean, lotus seed, stir-fried endothelium corneum gigeriae galli, raw hawthorn, medicated leaven, red yeast rice, stir-fried fructus setariae germinatus and liquorice root according to the formula; (2) Wash the above-mentioned medicinal materials, dry them in the air, and crush them into powders; (3) Put the powders in (2) into a multi-functional extraction tank, add water and heat, filter to obtain a filtrate and residues; (4) Put the residues in (3) into a multi-functional extraction tank, add water at 6 - 8 times the amount of the medicinal materials, heat for 2 - 3 h, filter to obtain a filtrate and residues; (5) Combine the filtrate in (3) and the filtrate in (4), filter, and let it stand; (6) Pump the supernatant of the filtrate after standing in (5) into a refrigeration tank and perform centrifugal separation in a cold sediment treatment room; (7) Pump the filtrate after centrifugation in (6) into another refrigeration tank and store it refrigerated for 24 - 36 h; (8) Filter and sterilize the filtrate in the refrigeration tank in (7); (9) Pump the sterilized filtrate in (8) into a dispensing tank in a dispensing room through a closed pipeline for sterilization; (10) Add the medicated leaven and red yeast rice in (1) to the dispensing tank containing the filtrate after sterilization in (9), cover the tank lid, heat to boiling, cool down, filter, and concentrate to obtain an extract; (11) Wash, dry, and sterilize the extract bottles in a drying room; (12) Fill the extract in (10) into the extract bottles in (11), seal the lids, sterilize, and package to obtain the finished extract; (13) Add the medicated leaven and red yeast rice in (1) to the dispensing tank containing the filtrate after sterilization in (9), prepare a solid dispersant using a pressure spray dryer, and package to obtain the finished solid dispersant.

4. The method according to claim 3, wherein The powders described in step (2) are 20 - 40 mesh powders.

5. The method according to claim 3, characterized in that The amount of water added in step (3) is 8 - 10 times the amount of the medicinal materials; the heating time is 3 - 4 h.